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delayed graft function

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https://www.readbyqxmd.com/read/29457274/impact-of-the-kidney-allocation-system-on-young-pediatric-recipients
#1
W F Parker, L F Ross, J R Thistlethwaite, A E Gallo
The Kidney Allocation System (KAS) altered pediatric candidate prioritization. We determined KAS' impact on pediatric kidney recipients by examining delayed graft function (DGF) rates from 2010-2016. A propensity score matched pediatric recipients pre- and post-KAS. A semi-parametric decomposition analysis estimated the contributions of KAS-related changes in donor characteristics and dialysis time on DGF rate. The unadjusted odds of DGF was 69% higher post-KAS for young (<10 years at listing) recipients (N = 1,153, p=0...
February 19, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29455505/-femoral-supracondylar-osteotomy-for-the-treatment-of-valgus-knee-osteoarthritis-in-young-and-middle-aged-patients
#2
Shi-Hui Xiao, Ding-Wei Liu, Fu-Cheng Yang, Xiang-Min Zhang
OBJECTIVE: To evaluate the clinical efficacy of open supracondylar osteotomy of the femoral condyle for the treatment of valgus knee osteoarthritis. METHODS: From April 2008 to June 2015, 21 patients with valgus knee osteoarthritis underwent an open wedge femoral supracondylar osteotomy using the distal femur dissection plates combined with autologous iliac bone graft for the bone defect. There were 8 males (8 knees) and 13 females (15 knees), ranging in age from 30 to 54 years old, with a mean age of 41...
August 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29446251/a-novel-technique-for-en-bloc-kidney-transplantation-from-infant-donors-with-extremely-low-body-weight-by-using-the-distal-abdominal-aorta-as-an-outflow-tract
#3
Helong Dai, Longkai Peng, Fenghua Peng, Gongbin Lan, Yu Wang, Jingjing Chen, Lei Liu, Chen Gao, Yong Guo, Chunhua Fang, Manhua Nie, Wang Long, Shaojie Yu
Pediatric kidney donors remain underutilized due to the high risk of postoperative thrombosis. To address this problem, we developed a novel en bloc kidney transplantation technique using donor thoracic aorta and the distal abdominal aorta as inflow and outflow tracts, respectively. Briefly, 8 kidneys from deceased infant donors under 5 months old and with low body weight (1.9-4.9 kg) were transplanted en bloc into 4 pediatric and 4 adult patients. The donor's common iliac artery or external iliac artery was anastomosed to the recipient's distal external iliac artery or inferior epigastric artery, respectively, as an outflow tract...
February 15, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29446225/impact-of-ureteral-stricture-and-treatment-choice-on-long-term-graft-survival-in-kidney-transplantation
#4
E Arpali, T Al-Qaoud, E Martinez, R R Redfield, G E Leverson, D B Kaufman, J S Odorico, H W Sollinger
We aimed to evaluate the influence of urological complications occurring within the first year after kidney transplantation on long-term patient and graft outcomes, and sought to examine the impact of the management approach of ureteral strictures on long-term graft function. We collected data on urological complications occurring within the first-year post-transplant. Graft survivals, patient survival, and rejection rates were compared between recipients with and without urological complications. Male gender of the recipient, delayed graft function, donor age were found to be significant risk factors for urological complications after kidney transplantation (p<0...
February 15, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29443957/bone-cement-augmented-short-segment-pedicle-screw-fixation-for-k%C3%A3-mmell-disease-with-spinal-canal-stenosis
#5
Yan-Sheng Huang, Chao-Yuan Ge, Hang Feng, Hai-Ping Zhang, Xing-Bang Niu, Shao-Yan Shi, Zi-Qi Zhu, Ding-Jun Hao
BACKGROUND This study aimed to explore the feasibility and efficacy of bone cement-augmented short-segmental pedicle screw fixation in treating Kümmell disease. MATERIAL AND METHODS From June 2012 to June 2015, 18 patients with Kümmell disease with spinal canal stenosis were enrolled in this study. Each patient was treated with bone cement-augmented short-segment fixation and posterolateral bone grafting, and posterior decompression was performed when needed. All patients were followed up for 12-36 months...
February 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29437064/the-challenge-of-monteggia-like-lesions-of-the-elbow-mid-term-results-of-46-cases
#6
P Jungbluth, S Tanner, J Schneppendahl, J-P Grassmann, M Wild, M Hakimi, J Windolf, R Laun
AIMS: The aim of this retrospective multicentre study was to evaluate mid-term results of the operative treatment of Monteggia-like lesions and to determine the prognostic factors that influence the clinical and radiological outcome. PATIENTS AND METHODS: A total of 46 patients (27 women and 19 men), with a mean age of 57.7 years (18 to 84) who had sustained a Monteggia-like lesion were followed up clinically and radiologically after surgical treatment. The Mayo Modified Wrist Score (MMWS), Mayo Elbow Performance Score (MEPS), Broberg and Morrey Score, and Disabilities of the Arm, Shoulder and Hand (DASH) score were used for evaluation at a mean of 65 months (27 to 111) postoperatively...
February 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29434741/inhibition-of-c-x-c-motif-chemokine-10-reduces-graft-loss-mediated-by-memory-cd8-t-cells-in-a-rat-cardiac-re-transplant-model
#7
Jiacheng Xu, Teng Ma, Guorong Deng, Jiawei Zhuang, Cheng Li, Shaohu Wang, Chen Dai, Xiaobiao Zhou, Zhonggui Shan, Zhongquan Qi
The interaction of chemokine (C-X-C motif) ligand 10 (CXCL10) with its receptor (CXCR3) is a critical process in recruiting donor reactive T cells to a graft and alloantigen-specific memory T (Tm) cells exert a principal function in promoting graft dysfunction during accelerated cardiac rejection. However, whether CXCL10 chemokine exerts any effects on acute accelerated rejection mediated by CD8+ Tm cells in a re-transplant model has remained elusive. The present study established a cardiac transplant model by advanced microsurgery technology and improved organ storage...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29425828/outcomes-of-renal-transplant-from-donors-with-polycystic-kidney-disease
#8
REVIEW
Awad Shamali, Sarah Milsom-Mcquillan, Paul Gibbs
INTRODUCTION: Kidneys from donors affected by autosomal-dominant polycystic kidney disease (ADPKD) are, in general, considered unsuitable for transplantation. However, some authors report cases of patients who received kidneys from a deceased ADPKD donor showing encouraging outcomes. Our aim is to provide our experience of a patient with end stage renal failure who received a deceased donor kidney from a 29-year-old who themselves had been diagnosed with ADPKD but well maintained renal function, and to provide a comprehensive review of all the published literature...
February 6, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29423212/chronic-kidney-disease-kidney-transplantation-and-oxidative-stress-a-new-look-to-successful-kidney-transplantation
#9
Hossein Tabriziani, Michael S Lipkowitz, Nhan Vuong
Oxidative stress plays a key role in the pathophysiological process of uremia and its complications, particularly in cardiovascular disease. The level of oxidative stress markers is known to increase as chronic kidney disease progresses and correlates significantly with the level of renal function. Hemodialysis and peritoneal dialysis are major modes of renal replacement therapy for end-stage renal disease patients, but unfortunately they are also accompanied by increased oxidative stress. Successful kidney transplantation, however, results in near normalization of the antioxidant status and lipid metabolism by eliminating free radicals despite the surge of oxidative stress caused by the surgical procedure and ischemic injury to the organ during the operation...
February 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29420729/combination-treatment-with-exogenous-gdnf-and-fetal-spinal-cord-cells-results-in-better-motoneuron-survival-and-functional-recovery-after-avulsion-injury-with-delayed-root-reimplantation
#10
Carolin Ruven, Smaranda-Ruxandra Badea, Wai-Man Wong, Wutian Wu
When spinal roots are torn off from the spinal cord, both the peripheral and central nervous system get damaged. As the motoneurons lose their axons, they start to die rapidly, whereas target muscles atrophy due to the denervation. In this kind of complicated injury, different processes need to be targeted in the search for the best treatment strategy. In this study, we tested glial cell-derived neurotrophic factor (GDNF) treatment and fetal lumbar cell transplantation for their effectiveness to prevent motoneuron death and muscle atrophy after the spinal root avulsion and delayed reimplantation...
February 6, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29416727/evaluation-of-predictive-models-for-delayed-graft-function-of-deceased-kidney-transplantation
#11
Huanxi Zhang, Linli Zheng, Shuhang Qin, Longshan Liu, Xiaopeng Yuan, Qian Fu, Jun Li, Ronghai Deng, Suxiong Deng, Fangchao Yu, Xiaoshun He, Changxi Wang
Background: This study aimed to evaluate the predictive power of five available delayed graft function (DGF)-prediction models for kidney transplants in the Chinese population. Results: Among the five models, the Irish 2010 model scored the best in performance for the Chinese population. Irish 2010 model had an area under the receiver operating characteristic (ROC) curve of 0.737. Hosmer-Lemeshow goodness-of-fit test showed that the Irish 2010 model had a strong correlation between the calculated DGF risk and the observed DGF incidence (p = 0...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29407336/perfusion-parameters-of-donation-after-cardiac-death-kidneys-predict-early-transplant-outcomes-based-on-expanded-criteria-donor-designation
#12
Q Tai, W Xue, X Ding, P Tian, H Xiang, X Feng, H Yan, J Hou
BACKGROUND: Donation after cardiac death is the only source of the deceased donor in China at present. Hypothermic machine perfusion has been used increasingly over the years. We determined the hypothermic machine perfusion parameters associated with early transplant outcomes based on the expanded criteria donor (ECD) designation. METHODS: There were 446 consecutive kidneys donated after cardiac death and preserved by hypothermic machine perfusion (LifePort) in our center that were included in this study...
January 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29407330/kidneys-with-small-renal-cell-carcinoma-used-in-transplantation-after-ex%C3%A2-vivo-partial-nephrectomy
#13
X Wang, X Zhang, T Men, Y Wang, H Gao, Y Meng, J Wang
BACKGROUND: The increase in the prevalence of end-stage renal disease in developed countries and the shortage of deceased donors have made it necessary to increase the graft pool by means of several strategies, such as living donation, non-heart-beating organ donors, and expanded-criteria donors. This study aimed to assess the short-term outcomes of donor kidneys with small (≤3.5 cm) renal cell carcinoma (sRCC) and to evaluate the possibility of using marginal kidneys in renal transplantation...
January 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29407316/functional-results-of-renal-preservation-in-hypothermic-pulsatile-machine-perfusion-versus-cold-preservation-systematic-review-and-meta-analysis-of-clinical-trials
#14
L Martínez Arcos, J J Fabuel Alcañiz, V Gómez Dos Santos, F J Burgos Revilla
BACKGROUND: Hypothermic pulsatile machine perfusion (HPMP) decreases the rate of delayed graft function (DGF) in kidney grafts, compared with cold storage. However, it is not clear its use in the different subgroups of grafts. The objective was to review systematically all studies with better methodologic quality that compare HPMP versus cold storage. METHODS: A systematic review was performed. The sources were Pubmed, Pubmed Central, Cochrane Library, Clinical Key, and Ovid...
January 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29402156/donor-body-mass-index-as-a-risk-factor-for-delayed-onset-of-graft-function
#15
Juraj Miklušica, Ivana Dedinská, Blažej Palkoci, Alexander Sendrey, Mariana Lajčiaková, Martin Vojtko, Denisa Osinová, L'udovít Laca
Delayed graft function continues to pose a significant challenge to clinicians in the context of kidney transplantation. The objective of this retrospective, 5-year analysis is to identify the parameters of beating heart donors and those of recipients that affect the delayed development of graft function. The monitored group was composed of 152 beating heart donors and 179 recipients. Delayed graft function was identified in 32 (17%) patients. The predictor for development of delayed graft function was the body mass index of the donor (odds ratio: 1...
January 1, 2018: Progress in Transplantation
https://www.readbyqxmd.com/read/29396785/a-randomized-prospective-study-of-laparoendoscopic-single-site-plus-one-port-versus-mini-laparoscopic-technique-for-live-donor-nephrectomy
#16
Kyu Won Lee, Sae Woong Choi, Yong Hyun Park, Woong Jin Bae, Yong Sun Choi, U-Syn Ha, Sung-Hoo Hong, Ji Youl Lee, Sae Woong Kim, Hyuk Jin Cho
PURPOSE: To compare the clinical outcomes of laparoendoscopic single-site plus one-port donor nephrectomy (LESSOP-DN) and mini laparoscopic donor nephrectomy (MLDN). METHODS: A prospective randomized controlled trial was conducted from December 2014 to February 2016 in donors scheduled for left donor nephrectomy. Donor and recipient demographics and clinical outcomes including pain scores and questionnaires (BIQ: body image questionnaire, SF-36, patient-reported overall convalescence) were also compared...
February 2, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29392612/robotic-assisted-renal-transplantation-with-total-extraperitonealization-of-the-graft-experience-of-34-cases
#17
Kishore Thekke Adiyat, Kumar K Vinod, Raveendran Vishnu, M K Ramaprasad, Vavullipathy N Unni, Roy P John
The aim of the study is to elucidate the method of complete extraperitonealization of the graft while performing transperitoneal robotic renal transplant recipient operation. This is a retrospective study of 34 robotic-assisted kidney transplant (RAKT) utilizing our technique from July 2015 to June 2017. The study is performed in a quaternary private hospital setting. The surgery was performed using our novel peritoneal flap technique allowing complete extraperitonealization of the kidney. Total of 34 patients underwent RAKT in our hospital...
February 1, 2018: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/29391389/does-enteric-conversion-affect-graft-survival-after-pancreas-transplantation-with-bladder-drainage
#18
Ji Yoon Choi, Joo Hee Jung, Hyun Wook Kwon, Sung Shin, Young Hoon Kim, Duck Jong Han
BACKGROUND Although bladder drainage is effective for monitoring urine amylase levels to detect graft rejection, enteric drainage is performed more frequently. The optimal method for monitoring pancreatic enzyme secretions remains unclear. We investigated graft survival in recipients of bladder drainage and assessed the risk of graft rejection and failure after enteric conversion. MATERIAL AND METHODS From January 1999 to October 2015, we performed 318 pancreas transplantations at our institution. We enrolled 180 recipients who underwent pancreas transplantation with bladder drainage (82 underwent enteric conversion and the rest did not)...
February 2, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29380523/dcd-donor-hemodynamics-as-predictor-of-outcome-after-kidney-transplantation
#19
H Peters-Sengers, J H E Houtzager, M B A Heemskerk, M M Idu, R C Minnee, R W Klaasen, S E Joor, J A M Hagenaars, P M Rebers, J J Homan van der Heide, J I Roodnat, F J Bemelman
Insufficient hemodynamics during agonal phase-i.e. the period between withdrawal of life-sustaining treatment and circulatory arrest-in Maastricht category III circulatory-death donors (DCD) potentially exacerbate ischemia/reperfusion injury. We included 409 Dutch adult recipients of DCD donor kidneys transplanted between 2006 and 2014. Peripheral oxygen saturation (SpO2-with pulse oximetry at the fingertip) and systolic blood pressure (SBP-with arterial catheter) were measured during agonal phase, and were dichotomized into minutes of SpO2>60% or SpO2<60%, and minutes of SBP>80 mmHg or SBP<80 mmHg...
January 30, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29377474/a-prospective-randomized-controlled-trial-of-eculizumab-to-prevent-ischemia-reperfusion-injury-in-pediatric-kidney-transplantation
#20
Michael Kaabak, Nadeen Babenko, Ron Shapiro, Allan Zokoyev, Olga Dymova, Edward Kim
Ischemia-reperfusion injury has multiple effects on a transplanted allograft, including delayed or impaired graft function, compromised long-term survival, and an association with an increased incidence of rejection. Eculizumab, a monoclonal antibody blocking terminal complement activation, has been postulated to be an effective agent in the prevention or amelioration of IRI. We performed a single-center prospective, randomized controlled trial involving 57 pediatric kidney transplant recipients between 2012 and 2016...
January 29, 2018: Pediatric Transplantation
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