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Sanket Newale, Deepak S Bachani
AIM: The study was conducted to understand the demographics, prevalence of co-morbid conditions and treatment modalities of depression. METHODS: A cross-sectional, nationwide observational study was conducted to understand the management pattern of depression in India. Depression was majorly diagnosed with DSM-IV TR criteria. RESULTS: The data of 2276 Indian patients across 18 states were collected through 135 mental health professionals. The study population was predominantly from urban (81...
October 2016: Journal of the Association of Physicians of India
Bartosz Gląb, Mirela Beganovic, Sanket Anaokar, Meng-Shu Hao, Allan Rasmusson, Jana Patton-Vogt, Antoni Banaś, Sten Stymne, Ida Lager
Glycero-3-phosphocholine (GPC), the product of the complete deacylation of phosphatidylcholine (PC), was long thought to not be a substrate for reacylation. However it was recently shown that cell-free extracts from yeast and plants could acylate GPC with acyl groups from acyl-CoA. By screening enzyme activities of extracts derived from a yeast knock-out collection, we were able to identify and clone the yeast gene (GPC1) encoding the enzyme, named glycerophosphocholine acyltransferase (GPCAT). By homology search we also identified and cloned GPCAT genes from three plant species...
October 7, 2016: Journal of Biological Chemistry
Renu Vyas, Sanket Bapat, Esha Jain, Muthukumarasamy Karthikeyan, Sanjeev Tambe, Bhaskar D Kulkarni
In order to understand the molecular mechanism underlying any disease, knowledge about the interacting proteins in the disease pathway is essential. The number of revealed protein-protein interactions (PPI) is still very limited compared to the available protein sequences of different organisms. Experiment based high-throughput technologies though provide some data about these interactions, those are often fairly noisy. Computational techniques for predicting protein-protein interactions therefore assume significance...
September 30, 2016: Computational Biology and Chemistry
Sanket Patil G, Suresh Sr
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Sanket Patil G, Suresh Sr
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Sabarinath, Sanket Shah, Lavanya, Rama Bhat
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Mohit Mahajan, Sanket Patil G
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Mohit Mahajan, Sanket Patil G
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Pallavi Vij, Deepti Sharma, C P Meena, Sanket Singh, Javed Sayyed
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Javed Sayyed, Deepti Sharma, C P Meena, Sanket Singh, Pallavi Vij
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Andrea G Kattah, Dawn C Scantlebury, Sanket Agarwal, Michelle M Mielke, Walter A Rocca, Amy L Weaver, Lisa E Vaughan, Virginia M Miller, Tracey L Weissgerber, Wendy White, Vesna D Garovic
BACKGROUND: Several registry-based studies, using diagnostic codes, have suggested that preeclampsia is a risk factor for end-stage renal disease (ESRD). However, because the 2 diseases share risk factors, the true nature of their association remains uncertain. Our goals were to conduct a population-based study to determine the magnitude of the association between preeclampsia and ESRD and evaluate the role of shared risk factors. STUDY DESIGN: Population-based nested case-control study...
October 1, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Andrew J Foy, Sanket S Dhruva, John Mandrola
No abstract text is available yet for this article.
September 23, 2016: Academic Radiology
Sanket A Deshmukh, Lee A Solomon, Ganesh Kamath, H Christopher Fry, Subramanian K R S Sankaranarayanan
Understanding the role of water in governing the kinetics of the self-assembly processes of amphiphilic peptides remains elusive. Here, we use a multistage atomistic-coarse-grained approach, complemented by circular dichroism/infrared spectroscopy and dynamic light scattering experiments to highlight the dual nature of water in driving the self-assembly of peptide amphiphiles (PAs). We show computationally that water cage formation and breakage near the hydrophobic groups control the fusion dynamics and aggregation of PAs in the micellar stage...
2016: Nature Communications
Yaoming Wang, Zhen Zhao, Sanket V Rege, Min Wang, Gabriel Si, Yi Zhou, Su Wang, John H Griffin, Steven A Goldman, Berislav V Zlokovic
Activated protein C (APC) is a blood protease with anticoagulant activity and cell-signaling activities mediated by the activation of protease-activated receptor 1 (F2R, also known as PAR1) and F2RL1 (also known as PAR3) via noncanonical cleavage. Recombinant variants of APC, such as the 3K3A-APC (Lys191-193Ala) mutant in which three Lys residues (KKK191-193) were replaced with alanine, and/or its other mutants with reduced (>90%) anticoagulant activity, engineered to reduce APC-associated bleeding risk while retaining normal cell-signaling activity, have shown benefits in preclinical models of ischemic stroke, brain trauma, multiple sclerosis, amyotrophic lateral sclerosis, sepsis, ischemic and reperfusion injury of heart, kidney and liver, pulmonary, kidney and gastrointestinal inflammation, diabetes and lethal body radiation...
September 2016: Nature Medicine
Sujata S Jha, Sanket J Joshi, Geetha S J
The possible application of a bacterial strain - Bacillus subtilis R1, isolated from an oil contaminated desert site in India, as biocontrol agent and its biosurfactant in microbial enhanced oil recovery are discussed. The biosurfactant production in minimal medium was carried out at different temperatures and salt concentrations, where it produced an efficient biosurfactant at 30-45°C and in presence of up to 7% salt. It significantly reduced the surface tension from 66±1.25mN/m to 29±0.85mN/m within 24h...
October 2016: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
Tushar P Patel, Komal Rawal, Sanket Soni, Sarita Gupta
Swertiamarin, a bitter secoiridoid glycoside, is an antidiabetic drug with lipid lowering activity meliorates insulin resistance in Type 2 Diabetes condition. Therefore, the study was designed to explore the antioxidant and hypolipidemic activity of swertiamarin in ameliorating NAFLD caused due to hepatic lipid accumulation, inflammation and insulin resistance. Steatosis was induced in HepG2 cells by supplementing 1mM oleic acid (OA) for 24h which was marked by significant accumulation of lipid droplets. This was determined by Oil Red O (ORO) staining and triglyceride accumulation...
August 1, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Sidney W Fu, Saurabh P Kirolikar, Erika Ginsburg, Xiaohui Tan, Arnold Schwartz, Samuel J Simmens, Yan-Gao Man, Joseph J Pinzone, Christine Teal, Sanket Awate, Barbara K Vonderhaar, Patricia E Berg
Expression of Beta Protein 1 (BP1), a homeotic transcription factor, increases during breast cancer progression and may be associated with tumor aggressiveness. In our present work, we investigate the influence of BP1 on breast tumor formation and size in vitro and in vivo. Cells overexpressing BP1 showed higher viability when grown in the absence of serum (p < 0.05), greater invasive potential (p < 0.05) and formed larger colonies (p < 0.004) compared with the controls. To determine the influence of BP1 overexpression on tumor characteristics, MCF-7 cells transfected with either empty vector (V1) or overexpressor plasmids (O2 and O4) were injected into the fat pads of athymic nude mice...
July 16, 2016: Oncotarget
Ekant Surendra Gupta, Sanket Pranjivan Sheth, Jaishree Deepak Ganjiwale
INTRODUCTION: Prevalence of Vitamin B12 deficiency has increased in community in recent time. Possibility is raised for new and yet unidentified factors being associated with this increased prevalence. One of these factors frequently questioned is use of Reverse Osmosis (RO) processed water for drinking. AIM: We aimed to study association of use of RO processed water for drinking with Vitamin B12 deficiency. MATERIALS AND METHODS: This cross-sectional study was done at tertiary care centre of Western India...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
Andrew Ulvestad, Kiran Sasikumar, Jong Woo Kim, Ross Harder, Evan Maxey, Jesse N Clark, Badri Narayanan, Sanket A Deshmukh, Nicola Ferrier, Paul Mulvaney, Subramanian K R S Sankaranarayanan, Oleg G Shpyrko
Multielectron transfer processes are crucially important in energy and biological science but require favorable catalysts to achieve fast kinetics. Nanostructuring catalysts can dramatically improve their properties, which can be difficult to understand due to strain- and size-dependent thermodynamics, the influence of defects, and substrate-dependent activities. Here, we report three-dimensional (3D) imaging of single gold nanoparticles during catalysis of ascorbic acid decomposition using Bragg coherent diffractive imaging (BCDI)...
August 4, 2016: Journal of Physical Chemistry Letters
Mukta Kulkarni, Shubhangi Shetkar, Prathamesh Joshi, Sanket Kasaliwal, Shrikant Chaudhari
A 30-year-old woman underwent Tc-pertechnetate scintigraphy for evaluation of thyrotoxicosis. The scintigraphy revealed hypervascular thyroid gland with markedly increased trapping function in both the lobes suggesting diagnosis of Graves disease. Incidentally, a hypervascular and pertechnetate avid focus was seen along the lateral margin of the right parotid gland. Pertechnetate avidity and site of uptake suggested possibility of Warthin tumor. Clinical examination and ultrasonography revealed a well-defined lesion in the superficial lobe of the right parotid gland favoring diagnosis of benign lesion...
September 2016: Clinical Nuclear Medicine
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