Read by QxMD icon Read


Faiza H Waghu, Shaini Joseph, Sanket Ghawali, Elvis A Martis, Taruna Madan, Kareenhalli V Venkatesh, Susan Idicula-Thomas
Antimicrobial peptides (AMPs) are gaining attention as substitutes for antibiotics in order to combat the risk posed by multi-drug resistant pathogens. Several research groups are engaged in design of potent anti-infective agents using natural AMPs as templates. In this study, a library of peptides with high sequence similarity to Myeloid Antimicrobial Peptide (MAP) family were screened using popular online prediction algorithms. These peptide variants were designed in a manner to retain the conserved residues within the MAP family...
2018: Frontiers in Microbiology
Daniel J Morgan, Sanket S Dhruva, Deborah Korenstein
No abstract text is available yet for this article.
March 1, 2018: JAMA Internal Medicine
Sagar Katva, Satyajeet Das, Harpreet Singh Moti, Anupam Jyoti, Sanket Kaushik
Background: Enterococcus faecalis (Ef) is a multidrug-resistant pathogenic bacteria associated with hospital-acquired infections. Ef is involved in a number of infectious diseases. It generally infects patients with the weekend immune system, i.e. a person mostly acquires Ef infections in the hospital, especially in intensive care units and thus, is more likely to be resistant to many antibiotics. Development of resistance against various antibiotics and emergence of drug-resistant strains is a growing global concern...
January 2018: Pharmacognosy Magazine
Sanni Kumar, Ena Gupta, Sanket Kaushik, Vijay Kumar Srivastava, Sudhir Kumar Mehta, Anupam Jyoti
Sepsis is a condition caused by infection followed by unregulated inflammatory response which may lead to the organ dysfunction. During such condition, over-production of oxidants is one of the factors which contribute cellular toxicity and ultimately organ failure and mortality. Antioxidants having free radicals scavenging activity exert protective role in various diseases. The present study has been designed to evaluate the levels of oxidative and anti-oxidative activity in sepsis patients and their correlation with the severity of the sepsis...
February 27, 2018: Scandinavian Journal of Immunology
Sanket Patel, Tahir Hussain
No abstract text is available yet for this article.
February 26, 2018: Hypertension
Sonia K Makhija, James D Bader, Daniel A Shugars, Mark S Litaker, Sanket Nagarkar, Valeria V Gordan, D Brad Rindal, Daniel J Pihlstrom, Rahma Mungia, Cyril Meyerowitz, Gregg H Gilbert
BACKGROUND: A suspicious occlusal carious lesion (SOCL) can be defined as a lesion with no cavitation and no radiographic radiolucency but for which caries is suspected. The authors evaluated whether using a device changed the percentage of SOCLs that were opened surgically and, among those SOCLs that were opened, the proportion that had penetrated into dentin. METHODS: Eighty-two dentists participated. In phase 1 of the study, dentists identified approximately 20 SOCLs, obtained patient consent, and recorded information about the lesion, treatment or treatments, and depth, if opened...
February 20, 2018: Journal of the American Dental Association
Kareem Osman, Sanket Srinivasa, Jonathan Koea
AIM: Historically, liver abscesses (LA) affected elderly, immunocompromised patients and were characterised by high morbidity and mortality, however there are no data pertaining to a New Zealand population with little information surrounding recent management trends. METHODS: A retrospective review of demographic characteristics, clinical management and microbiological data on patients presenting with liver abscess between 2005-2014 was conducted. RESULTS: Fifty-seven patients [37 males, median age 64 (range 15-87)] presented with LA and most patients were not comorbid...
February 23, 2018: New Zealand Medical Journal
Sujoy Banerjee, Rajlakshmi Banerjee, Usha Shenoy, Sanket Agarkar, Sangeeta Bhattacharya
Introduction: Pain is an important aspect of oral health-related quality of life (OHRQOL). Understanding how patients' pain experiences during their treatment affect their quality of life (QOL) is important and the absence of pain/discomfort is important for achieving a high QOL. Aim and Objective: The objective of this study was to assess the relationship between pain and OHRQOL among patients wearing fixed orthodontic appliances and to evaluate whether patient motivation and counseling had an effect on the pain and discomfort...
January 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
Gaurang G Gowande, Sanket Tembe, Hemant V Ghate
Cytochrome c oxidase subunit I gene (COI) sequences of roughly 509 bp length for various species of the Infraorder Pentatomomorpha were generated. K2P divergences within and between species and genera were calculated and compared using newly generated sequences and the ones available on online portals. Mean interspecific (within-genus) genetic divergence (14.23%) was ∼ eight times greater than mean intraspecific (within-species) divergence (1.79%). Distance-based as well as character-based approaches were used towards constructing (COI) trees...
February 1, 2018: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
Sanket R Nagarkar, Jorge Perdigão, Wook-Jin Seong, Nicole Theis-Mahon
BACKGROUND: The primary objective of this systematic review was to investigate the survival of full-coverage restorations fabricated by using digital impressions (DIs) versus that of those fabricated by using conventional impressions. The authors also compared secondary outcomes of marginal and internal fit and occlusal and interproximal contacts. TYPES OF STUDIES REVIEWED: The authors conducted a systematic literature search in multiple databases to identify clinical trials with no restrictions by publication type, date, or language...
February 2018: Journal of the American Dental Association
Anuj Khandelwal, Caitlin N Kent, Maurie Balch, Shuxia Peng, Sanket J Mishra, Junpeng Deng, Victor W Day, Weiya Liu, Chitra Subramanian, Mark Cohen, Jeffery M Holzbeierlein, Robert Matts, Brian S J Blagg
The 90 kDa heat shock protein (Hsp90) is a molecular chaperone responsible for folding proteins that are directly associated with cancer progression. Consequently, inhibition of the Hsp90 protein folding machinery results in a combinatorial attack on numerous oncogenic pathways. Seventeen small-molecule inhibitors of Hsp90 have entered clinical trials, all of which bind the Hsp90 N-terminus and exhibit pan-inhibitory activity against all four Hsp90 isoforms. pan-Inhibition of Hsp90 appears to be detrimental as toxicities have been reported alongside induction of the pro-survival heat shock response...
January 30, 2018: Nature Communications
Ganesh Sankaranarayanan, Lizzy Wooley, Deborah Hogg, Denis Dorozhkin, Jaisa Olasky, Sanket Chauhan, James W Fleshman, Suvranu De, Daniel Scott, Daniel B Jones
BACKGROUND: SAGES FUSE curriculum provides didactic knowledge on OR fire prevention. The objective of this study is to evaluate the impact of an immersive virtual reality (VR)-based OR fire training simulation system in combination with FUSE didactics. METHODS: The study compared a control with a simulation group. After a pre-test questionnaire that assessed the baseline knowledge, both groups were given didactic material that consists of a 10-min presentation and reading materials about precautions and stopping an OR fire from the FUSE manual...
January 25, 2018: Surgical Endoscopy
Satish Balkrishna Dharap, Sanket Vishnu Ekhande
BACKGROUND & OBJECTIVES: Trauma is known to lead to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS), which is often a cause of late deaths after injury. SIRS and MODS have been objectively measured using scoring systems. This prospective observational study was carried out in a tertiary care hospital in India to evaluate SIRS and MODS following trauma in terms of their incidence, the associated risk factors and the effect on the outcome. METHODS: All adult patients with major life- and limb-threatening trauma were included...
September 2017: Indian Journal of Medical Research
Karteek K Bejagam, Samrendra Singh, Yaxin An, Carter Berry, Sanket A Deshmukh
We have employed two-to-one mapping scheme to develop three coarse-grained (CG) water models, namely, 1-, 2-, and 3-site CG models. Here, for the first time, particle swarm optimization (PSO) and gradient descent methods were coupled to optimize the force-field parameters of the CG models to reproduce the density, self-diffusion coefficient, and dielectric constant of real water at 300 K. The CG MD simulations of these new models conducted with various timesteps, for different system sizes, and at a range of different temperatures are able to predict the density, self-diffusion coefficient, dielectric constant, surface tension, heat of vaporization, hydration free energy, and isothermal compressibility of real water with excellent accuracy...
January 22, 2018: Journal of Physical Chemistry. B
Alexander C Egilman, Joshua D Wallach, Joseph S Ross, Sanket S Dhruva
No abstract text is available yet for this article.
January 16, 2018: JAMA Internal Medicine
Sanket S Shah, Sudhi P Kurup, Hantamalala Ralay Ranaivo, Rebecca B Mets-Halgrimson, Marilyn B Mets
BACKGROUND: Marfan syndrome (MFS) is a genetic disorder that affects multiple organ systems, including the eye. The most common ocular manifestations include ectopia lentis and retinal detachment. The current literature qualitatively cites that MFS patients have miotic or "poorly dilating" pupils. This study was the first to quantitatively assess pupillary function in MFS patients. MATERIALS AND METHODS: 57 eyes from 29 MFS patients, 36 eyes from 18 pediatric age- and gender-matched controls, and 44 eyes from 22 adult age-matched controls were measured in a clinic-based cross sectional study...
January 16, 2018: Ophthalmic Genetics
Sanket Newale, Deepak S Bachani
Aim: The study was conducted to understand the demographics, prevalence of co-morbid conditions and treatment modalities of depression. Methods: A cross-sectional, nationwide observational study was conducted to understand the management pattern of depression in India. Depression was majorly diagnosed with DSM-IV TR criteria. Results: The data of 2276 Indian patients across 18 states were collected through 135 mental health professionals. The study population was predominantly from urban (81...
October 2017: Journal of the Association of Physicians of India
Sanket Kaushik, Naseer Iqbal, Nagendra Singh, Juhi Sikarwar, Prashant K Singh, Pradeep Sharma, Punit Kaur, Sujata Sharma, Mohammad Owais, Tej P Singh
Peptidyl-tRNA hydrolase (Pth) catalyzes the breakdown of peptidyl-tRNA into peptide and tRNA components. Pth from Acinetobacter baumannii ( Ab Pth) was cloned, expressed, purified and crystallized in native unbound ( Ab Pth-N) state and in bound state with phosphate ion and cytosine arabinoside (cytarabine) ( Ab Pth-C). Structures of Ab Pth-N and Ab Pth-C were determined at 1.36Å and 1.10Å resolutions respectively.  Structure of Ab Pth-N showed that the active site is filled with water molecules. In the structure of Ab Pth-C, a phosphate ion is present in the active site while cytarabine is bound in a cleft which is located away from the catalytic site...
January 4, 2018: Biochemical Journal
Sameer Salunkhe, Saket V Mishra, Jyothi Nair, Samadri Ghosh, Neha Choudhary, Ekjot Kaur, Sanket Shah, Ketaki Patkar, Dev Anand, Navin Khattry, Syed K Hasan, Shilpee Dutt
Leukemia is majorly treated by topoisomerase inhibitors that induce DNA double strand breaks (DSB) resulting in cell death. Consequently, modulation of DSB repair pathway renders leukemic cells resistant to therapy. Since we do not fully understand the regulation of DSB repair acquired by resistant cells, targeting these cells has been a challenge. Here we investigated the regulation of DSB repair pathway in Early Drug Resistant Population (EDRP) and Late Drug Resistant Population (LDRP). We found that doxorubicin induced equal DSBs in parent and EDRP cells however; cell death is induced only in the parent cells...
January 3, 2018: International Journal of Cancer. Journal International du Cancer
Seema Ramakrishnan, Kunal Mandlik, Tejashree Sanket Sathe, Joseph Gubert, Thiruvengada Krishnan, Prabu Baskaran
The aim of our retrospective study is to report a case series of ocular infections caused by a rare fungus, Scedosporium apiospermum, in a South Indian population. Thirteen cases of culture-positive S. apiospermum infections diagnosed between January 2011 and March 2016 were included in this study. The parameters evaluated were predisposing factors, treatment and final clinical outcome. The most common mode of presentation was keratitis (84.6%) followed by sclerokeratitis (15.3%). The predisposing factors involved were unspecified foreign body injury (30...
January 2018: Indian Journal of Ophthalmology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"