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https://www.readbyqxmd.com/read/29319248/detection-management-approach-of-depression-and-antidepressant-utilization-in-adult-patients-results-of-a-cross-sectional-survey
#1
Sanket Newale, Deepak S Bachani
Aim: The study was conducted to understand the demographics, prevalence of co-morbid conditions and treatment modalities of depression. Methods: A cross-sectional, nationwide observational study was conducted to understand the management pattern of depression in India. Depression was majorly diagnosed with DSM-IV TR criteria. Results: The data of 2276 Indian patients across 18 states were collected through 135 mental health professionals. The study population was predominantly from urban (81...
October 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29301982/search-of-multiple-hot-spots-on-the-surface-of-peptidyl-trna-hydrolase-structural-binding-and-antibacterial-studies
#2
Sanket Kaushik, Naseer Iqbal, Nagendra Singh, Juhi Sikarwar, Prashant K Singh, Pradeep Sharma, Punit Kaur, Sujata Sharma, Mohammad Owais, Tej P Singh
Peptidyl-tRNA hydrolase (Pth) catalyzes the breakdown of peptidyl-tRNA into peptide and tRNA components. Pth from Acinetobacter baumannii ( Ab Pth) was cloned, expressed, purified and crystallized in native unbound ( Ab Pth-N) state and in bound state with phosphate ion and cytosine arabinoside (cytarabine) ( Ab Pth-C). Structures of Ab Pth-N and Ab Pth-C were determined at 1.36Å and 1.10Å resolutions respectively.  Structure of Ab Pth-N showed that the active site is filled with water molecules. In the structure of Ab Pth-C, a phosphate ion is present in the active site while cytarabine is bound in a cleft which is located away from the catalytic site...
January 4, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29297932/inhibition-of-novel-gcn5-atm-axis-restricts-the-onset-of-acquired-drug-resistance-in-leukemia
#3
Sameer Salunkhe, Saket V Mishra, Jyothi Nair, Samadri Ghosh, Neha Choudhary, Ekjot Kaur, Sanket Shah, Ketaki Patkar, Dev Anand, Navin Khattry, Syed K Hasan, Shilpee Dutt
Leukemia is majorly treated by topoisomerase inhibitors that induce DNA double strand breaks (DSB) resulting in cell death. Consequently, modulation of DSB repair pathway renders leukemic cells resistant to therapy. Since we do not fully understand the regulation of DSB repair acquired by resistant cells, targeting these cells has been a challenge. Here we investigated the regulation of DSB repair pathway in Early Drug Resistant Population (EDRP) and Late Drug Resistant Population (LDRP). We found that doxorubicin induced equal DSBs in parent and EDRP cells however; cell death is induced only in the parent cells...
January 3, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29283143/ocular-infections-caused-by-scedosporium-apiospermum-a-case-series
#4
Seema Ramakrishnan, Kunal Mandlik, Tejashree Sanket Sathe, Joseph Gubert, Thiruvengada Krishnan, Prabu Baskaran
The aim of our retrospective study is to report a case series of ocular infections caused by a rare fungus, Scedosporium apiospermum, in a South Indian population. Thirteen cases of culture-positive S. apiospermum infections diagnosed between January 2011 and March 2016 were included in this study. The parameters evaluated were predisposing factors, treatment and final clinical outcome. The most common mode of presentation was keratitis (84.6%) followed by sclerokeratitis (15.3%). The predisposing factors involved were unspecified foreign body injury (30...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29218433/s8orf2-protein-of-infectious-salmon-anaemia-virus-is-a-rna-silencing-suppressor-and-interacts-with-salmon-salar-mov10-ssmov10-of-the-host-rnai-machinery
#5
Vandana Thukral, Bhavna Varshney, Rimatulhana B Ramly, Sanket S Ponia, Sumona Karjee Mishra, Christel M Olsen, Akhil C Banerjea, Sunil K Mukherjee, Rana Zaidi, Espen Rimstad, Sunil K Lal
The infectious salmon anaemia virus (ISAV) is a piscine virus, a member of Orthomyxoviridae family. It encodes at least 10 proteins from eight negative-strand RNA segments. Since ISAV belongs to the same virus family as Influenza A virus, with similarities in protein functions, they may hence be characterised by analogy. Like NS1 protein of Influenza A virus, s8ORF2 of ISAV is implicated in interferon antagonism and RNA-binding functions. In this study, we investigated the role of s8ORF2 in RNAi suppression in a well-established Agrobacterium transient suppression assay in stably silenced transgenic Nicotiana xanthi...
December 7, 2017: Virus Genes
https://www.readbyqxmd.com/read/29215916/new-and-incremental-fda-black-box-warnings-from-2008-to-2015
#6
Michael T Solotke, Sanket S Dhruva, Nicholas S Downing, Nilay D Shah, Joseph S Ross
BACKGROUND: The boxed warning (also known as "black box warning [BBW]") is one of the strongest drug safety actions that the U.S. Food & Drug Administration (FDA) can implement, and often warns of serious risks. The objective of this study was to comprehensively characterize BBWs issued for drugs after FDA approval. METHODS: We identified all post-marketing BBWs from January 2008 through June 2015 listed on FDA's MedWatch and Drug Safety Communications websites...
December 7, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29209573/trial-watch-immunogenic-cell-death-induction-by-anticancer-chemotherapeutics
#7
REVIEW
Abhishek D Garg, Sanket More, Nicole Rufo, Odeta Mece, Maria Livia Sassano, Patrizia Agostinis, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi
The expression "immunogenic cell death" (ICD) refers to a functionally unique form of cell death that facilitates (instead of suppressing) a T cell-dependent immune response specific for dead cell-derived antigens. ICD critically relies on the activation of adaptive responses in dying cells, culminating with the exposure or secretion of immunostimulatory molecules commonly referred to as "damage-associated molecular patterns". Only a few agents can elicit bona fide ICD, including some clinically established chemotherapeutics such as doxorubicin, epirubicin, idarubicin, mitoxantrone, bleomycin, bortezomib, cyclophosphamide and oxaliplatin...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29205829/acknowledging-pancreaticoduodenectomy-as-a-multi-visceral-resection
#8
Sanket Srinivasa, Jonathan B Koea
No abstract text is available yet for this article.
December 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29203986/crs-and-hipec-for-pmp-use-of-the-lc-cusum-to-determine-the-number-of-procedures-required-to-attain-a-minimal-level-of-proficiency-in-delivering-the-combined-modality-treatment
#9
Aditi Bhatt, Antony George, Sanket Mehta
The learning curve for cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for pseudomyxoma peritonei (PMP) which peaks at 90 procedures for the surgeon may take several years to reach. The cumulative summation (CUSUM) test of the learning curve (LC-CUSUM) was used to assess the safety of the procedure (minimal level of proficiency for the surgeon) in terms of morbidity, mortality, and completeness of cytoreduction and early oncological failure before the peak of the learning curve had been reached...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29203985/setting-up-of-the-indian-hipec-registry-a-registry-for-indian-patients-with-peritoneal-surface-malignancies
#10
Aditi Bhatt, Sanket Mehta, Ramakrishnan As, Pankaj Pande, Firoz Rajan, Ashvin Rangole, Avanish Saklani, Kayomarz Sethna, Shivendra Singh, Shabber Zaveri, K S Gopinath
There are various registries for patients with peritoneal metastases (PM) that aid pooling of data and generate evidence that dictates current clinical practice. This manuscript describes the setting up of the Indian HIPEC registry that was set up with a similar goal by a group of Indian surgeons. This is a registry for patients with PM treated with CRS and HIPEC in India. It also acts as a database for storing treatment-related information. Patients with PM from colorectal ovarian, gastric, appendiceal tumors, and other rare peritoneal tumors/metastases from rare tumors are enrolled in the registry...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29162961/pisat-s-visual-vasopressor-injection-needle-a-new-device-for-increasing-patient-safety-in-laparoscopic-myomectomy
#11
REVIEW
Sanket V Pisat
Introduction: The use of vasopressin and other vasoconstrictive agents to reduce blood loss during laparoscopic myomectomy significantly reduces blood loss and operative time. However, serious cardiovascular complications following the use of intra-myometrial injection of vasopressin solution have also been reported. Most of these side effects are believed to be due to inadvertent intravascular injection of vasopressin solution. Aims and Objectives: To describe a new design of an injection needle, Pisat's Visual Vasopressor Injection Needle (VVIN), that can be used during laparoscopic myomectomy to minimise the incidence of an inadvertent intravascular injection of a vasoconstrictor solution...
December 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/29133522/systolic-blood-pressure-response-in-sprint-systolic-blood-pressure-intervention-trial-and-accord-action-to-control-cardiovascular-risk-in-diabetes-a-possible-explanation-for-discordant-trial-results
#12
Chenxi Huang, Sanket S Dhruva, Andreas C Coppi, Frederick Warner, Shu-Xia Li, Haiqun Lin, Khurram Nasir, Harlan M Krumholz
BACKGROUND: SPRINT (Systolic Blood Pressure Intervention Trial) and the ACCORD (Action to Control Cardiovascular Risk in Diabetes) blood pressure trial used similar interventions but produced discordant results. We investigated whether differences in systolic blood pressure (SBP) response contributed to the discordant trial results. METHODS AND RESULTS: We evaluated the distributions of SBP response during the first year for the intensive and standard treatment groups of SPRINT and ACCORD using growth mixture models...
November 13, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29074878/a-guanidine-appended-scyllo-inositol-derivative-aad-66-enhances-brain-delivery-and-ameliorates-alzheimer-s-phenotypes
#13
Dohyun Lee, Woo-Sirl Lee, Sungsu Lim, Yun Kyung Kim, Hoe-Yune Jung, Sanket Das, Juhyun Lee, Wenjie Luo, Kyong-Tai Kim, Sung-Kee Chung
Alzheimer's disease (AD) is a degenerative brain disease that destroys memory and other important mental functions but lacks efficient therapeutic agents. Blocking toxic amyloid β (Aβ) could be beneficial for AD and represents a promising therapeutic strategy for AD treatment. scyllo-Inositol (SI) is a potential therapeutic for AD by directly interacting with the Aβ peptide to inhibit Aβ42 fiber formation. Clinical studies of SI showed promising benefits on mild to moderate AD, however, with limitations on dosage regime...
October 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29071169/draft-genome-sequence-of-a-thermostable-alkaliphilic-%C3%AE-amylase-and-protease-producing-bacillus-amyloliquefaciens-strain-kcp2
#14
Vimalkumar S Prajapati, Sanket Ray, Jitendra Narayan, Chaitanya C Joshi, Kamlesh C Patel, Ujjval B Trivedi, R M Patel
Bacillus amyloliquefaciens strain KCP2 was isolated from municipal food waste samples collected in Vallabh Vidyanagar, Gujarat, India. Strain KCP2 is noteworthy due to its ability to produce a thermostable, alkaliphilic α-amylase and a protease. These enzymes have importance in several industrial processes including bread making, brewing, starch processing, pharmacy, and textile industries. Whole genome sequencing of strain KCP2 showed that the estimated genome size was 3.9 Mb, the G + C content was 46%, and it coded for 4113 genes...
December 2017: 3 Biotech
https://www.readbyqxmd.com/read/29052693/medicare-formulary-coverage-restrictions-for-prescription-opioids-2006-to-2015
#15
Elizabeth A Samuels, Joseph S Ross, Sanket S Dhruva
No abstract text is available yet for this article.
October 10, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29049832/requiem-for-a-scaffold
#16
Sanket S Dhruva, Jeptha P Curtis
No abstract text is available yet for this article.
October 17, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29047414/histone-isoform-h2a1h-promotes-attainment-of-distinct-physiological-states-by-altering-chromatin-dynamics
#17
Saikat Bhattacharya, Divya Reddy, Vinod Jani, Nikhil Gadewal, Sanket Shah, Raja Reddy, Kakoli Bose, Uddhavesh Sonavane, Rajendra Joshi, Sanjay Gupta
BACKGROUND: The distinct functional effects of the replication-dependent histone H2A isoforms have been demonstrated; however, the mechanistic basis of the non-redundancy remains unclear. Here, we have investigated the specific functional contribution of the histone H2A isoform H2A1H, which differs from another isoform H2A2A3 in the identity of only three amino acids. RESULTS: H2A1H exhibits varied expression levels in different normal tissues and human cancer cell lines (H2A1C in humans)...
October 18, 2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/28989133/gingival-crevicular-fluid-turnover-markers-in-premenopausal-vs-postmenopausal-women-receiving-orthodontic-treatment
#18
Anusha Bitra, B Jhansi Rani, Sanket S Agarkar, Anuj S Parihar, Gopinath P Vynath, Shekhar Grover
BACKGROUND: Orthodontic treatment is one of the commonly used dental treatments. Orthodontic forces act on the bone by modulating the biomolecules, chiefly the osteoprotegerin (OPG), osteopontin (OPN), receptor activator of nuclear factor kappa-B (RANK), and RANK ligand (RANKL) (OPG ligand). Hormonal changes are known to cause marked alteration in the levels of these biomolecules. Hence, we planned this study to evaluate the response of bone biomarkers in the gingival crevicular fluid (GCF) in postmenopausal women undergoing fixed orthodontic therapy...
October 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28973402/2017-update-on-medical-overuse-a-systematic-review
#19
Daniel J Morgan, Sanket S Dhruva, Eric R Coon, Scott M Wright, Deborah Korenstein
Importance: Overuse of medical care is a well-recognized problem. Objective: To identify and highlight original research articles published in 2016 that are most relevant to understanding medical overuse or strategies to reduce it. Evidence Review: A structured review of English-language articles on PubMed published in 2016 coupled with examination of tables of contents of high-impact journals to identify articles related to medical overuse in adults...
January 1, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28973101/coronary-computed-tomography-angiography-vs-functional-stress-testing-for-patients-with-suspected-coronary-artery-disease-a-systematic-review-and-meta-analysis
#20
REVIEW
Andrew J Foy, Sanket S Dhruva, Brandon Peterson, John M Mandrola, Daniel J Morgan, Rita F Redberg
Importance: Coronary computed tomography angiography (CCTA) is a new approach for the diagnosis of anatomical coronary artery disease (CAD), but it is unclear how CCTA performs compared with the standard approach of functional stress testing. Objective: To compare the clinical effectiveness of CCTA with that of functional stress testing for patients with suspected CAD. Data Sources: A systematic literature search was conducted in PubMed and MEDLINE for English-language randomized clinical trials of CCTA published from January 1, 2000, to July 10, 2016...
November 1, 2017: JAMA Internal Medicine
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