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https://www.readbyqxmd.com/read/28503843/the-volume-cost-and-outcomes-of-pancreatic-resection-in-a-regional-centre-in-new-zealand
#1
Neil Wylie, Phillip Hider, Delwyn Armstrong, Sanket Srinivasa, Michael Rodgers, Anna Brown, Jonathan Koea
BACKGROUND: The frequency, costs and outcome of pancreatic resection (both pancreaticoduodenectomy and distal pancreatectomy) were reviewed in our own institution and correlated with regional population growth as well as national resection rates and locations. METHODS: Demographic, pathological and outcome data on pancreaticoduodenectomy and distal pancreatectomy were obtained from a prospectively maintained database for the years 2005-2009 and 2010-2014. During this period, the catchment population grew from 460 000 to 567 000...
May 14, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28461801/a-rare-case-of-vascular-ring-and-coarctation-of-the-aorta-in-association-with-charge-syndrome
#2
Jonathan B Wagner, Joshua Q Knowlton, Peter Pastuszko, Sanket S Shah
A male neonate presented with CHARGE syndrome, a multiorgan genetic disorder involving the Coloboma of the eyes, congenital Heart defects, nasal choanal Atresia, growth and development Retardation, Genitourinary disorders, and Ear anomalies and deafness. Moreover, he had a rare case of vascular ring-consisting of a right aortic arch with retroesophageal brachiocephalic artery-combined with coarctation of the mid-aortic arch. He underwent both vascular ring and aortic arch repair at our institution. To our knowledge, this is the 4th documented case of this exceedingly rare type of aortic arch anomaly combined with aortic arch obstruction...
April 2017: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/28455266/suppression-of-abcg2-mediated-mdr-in-vitro-and-in-vivo-by-a-novel-inhibitor-of-abcg2-drug-transport
#3
Atish Patel, Tian-Wen Li, Nagaraju Anreddy, De-Shen Wang, Kamlesh Sodani, Sanket Gadhia, Rishil Kathawala, Dong-Hua Yang, Changmei Cheng, Zhe-Sheng Chen
Cancer is a disease whose treatment is often limited due to the development of a phenomenon known as multidrug resistance (MDR). There is an immense demand for development of novel agents that can overcome the MDR in cancer. A group of transmembrane proteins called ATP-binding cassette transporters, present ubiquitously in the human body possesses a modular architecture, contributing immensely towards the development of MDR. An analysis of structural congeners among a group of compounds led to the discovery of CCTA-1523 that could selectively reverse ABCG2-mediated MDR in cancer cells in vitro and in vivo...
April 26, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28365962/outcomes-of-cytoreductive-surgery-and-hipec-for-pseudomyxoma-peritonei-of-appendiceal-origin-from-two-indian-centers-a-preliminary-five-year-experience
#4
Aditi Bhatt, Deepak Sheshadri, Garud Chandan, Veena Ramaswamy, Jeegeshwar Pandey, Nitin Bhorkar, Deepesh Agrawal, Sanket Mehta
PURPOSE: To evaluate the short-term outcomes of patients of pseudomyxoma peritonei (PMP) of appendiceal origin treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) at two tertiary Indian centers. METHODS: Data was prospectively collected from January 2011 to January 2016. Palliative procedures were excluded. HIPEC was performed by the coliseum technique using either a mitomycin or oxaliplatin-based regimen. RESULTS: 77 procedures were performed on 71 patients...
January 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28343151/gastric-outlet-obstruction-an-unusual-case-of-primary-duodenal-tuberculosis
#5
Sanket Kalpande, Jayashri Sanjay Pandya, Ajeet Tiwari, Devbrata Adhikari
BACKGROUND: Tuberculosis is a major health problem worldwide. Gastrointestinal tuberculosis presenting as isolated involvement of the duodenum is a rare case. CASE PRESENTATION: A 13 year male, presented with features of gastric outlet obstruction. CT enterography scan showed circumferential mural thickening in first and second part of duodenal junction causing luminal narrowing. Upper GI endoscopy confirmed the narrowing of D1-D2 junction. Duodenal biopsy showed duodenitis with negative result for AFB stain, Helicobacter Pylori...
March 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28330750/real-world-data-on-heart-failure-readmission-reduction-real-or-real-uncertain
#6
EDITORIAL
Harlan M Krumholz, Sanket S Dhruva
No abstract text is available yet for this article.
March 15, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28303785/fast-gas-chromatography-with-tandem-mass-spectrometry-analysis-of-selected-persistent-organic-pollutants-and-organophosphorus-and-synthetic-pyrethroid-pesticides-in-indian-prawn-fenneropenaeus-indicus-in-compliance-with-the-eu-mrls
#7
Durvesh Sawant, Jitendra Kelkar, Pratap Rasam, Ajit Datar, Prashant Hase, Dheeraj Handique, Ankush Bhone, Sanket Chiplunkar, Manish Hate
A fast GC with tandem MS method was developed and validated for multiresidue determination of 95 chemical contaminants (24 synthetic pyrethroids, 17 organochlorines, 17 organophosphorus compounds, 18 polycyclic aromatic hydrocarbons, and 19 polychlorinated biphenyls) in Indian prawns (Fenneropenaeus indicus) as per the European Union maximum residual limit requirements. Chromatographic separation and MS determination were achieved within a short run time of 18 min, without compromising sensitivity and specificity...
May 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28288250/fda-drug-trials-snapshots-a-clearer-picture
#8
Sanket S Dhruva, Rita F Redberg
No abstract text is available yet for this article.
May 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28277598/pisat-s-visual-vasopressor-injection-needle-an-innovative-tool-for-increasing-patient-safety-in-laparoscopic-myomectomy
#9
Sanket Pisat, Bruno van Herendael
INTRODUCTION: The use of vasopressin and other vasoconstrictive agents to reduce blood loss during laparoscopic myomectomy significantly reduces blood loss and operative time. However, serious cardiovascular complications following the use of intramyometrial injection of vasopressin solution have also been reported. Most of these side effects are believed to be due to inadvertent intravascular injection of vasopressin solution. AIMS AND OBJECTIVES: To describe a new design of an injection needle...
March 9, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28228307/comparative-study-of-cardiac-autonomic-status-by-heart-rate-variability-between-under-treatment-normotensive-and-hypertensive-known-type-2-diabetics
#10
Jayesh D Solanki, Sanket D Basida, Hemant B Mehta, Sunil J Panjwani, Bhakti P Gadhavi
BACKGROUND: Co-existence of hypertension is known in three quarter of Indian type 2 diabetics, this duo having adverse additive effect on cardiovascular health including dysautonomia. Latter can be measured by simple 5min heart rate variability (HRV) using simple electrocardiogram, which if reduced indicates cardiac risk. OBJECTIVE: We compared HRV parameters between hypertensive and normotensive type 2 diabetics, looking for significant difference if any. MATERIALS AND METHODS: 98 hypertensive and 40 normotensive type 2 diabetics treated as outpatients were evaluated for disease control and risk stratification...
January 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28217606/a-mixed-toxidrome-presenting-with-bilateral-ptosis-with-normal-pupils-the-first-case-in-the-literature
#11
Sanket Mahajan, Janki Shah
Snakebite is an environmental hazard associated with a significant morbidity and mortality. Two main types of toxicity occur due to snakebite, namely vasculotoxicity and neurotoxicity. Neurotoxic snakebites present mainly with bilateral ptosis with dilated pupils and/or difficulty in breathing. Jatropha curcas belongs to the family Euphorbiaceae and is commonly referred to as "Ratanjyot" in Gujarati. It has got many medicinal uses such as anticancerous properties and bio-oil. There are very few cases of its toxicity in adults...
July 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28197794/therapeutic-options-in-refractory-diabetic-macular-oedema
#12
REVIEW
Sanket U Shah, Raj K Maturi
Diabetic macular oedema (DMO) results from alterations of several biochemical pathways in diabetic eyes. Centre-involving DMO is an important cause of visual loss in diabetes. Anti-vascular endothelial growth factor agents are now the mainstay of centre-involving DMO treatment. Oedema that does not achieve optimal response to these agents occurs in a sizeable proportion of eyes and is called refractory or persistent DMO. Management of refractory DMO is challenging. In this paper, the pathophysiology of DMO, and the definitions used in various studies are summarised...
April 2017: Drugs
https://www.readbyqxmd.com/read/28196087/the-potential-of-indigenous-paenibacillus-ehimensis-bs1-for-recovering-heavy-crude-oil-by-biotransformation-to-light-fractions
#13
Biji Shibulal, Saif N Al-Bahry, Yahya M Al-Wahaibi, Abdulkadir E Elshafie, Ali S Al-Bemani, Sanket J Joshi
Microbial Enhanced Oil Recovery (MEOR) is a potential technology for residual heavy oil recovery. Many heavy oil fields in Oman and elsewhere have difficulty in crude oil recovery because it is expensive due to its high viscosity. Indigenous microbes are capable of improving the fluidity of heavy oil, by changing its high viscosity and producing lighter oil fractions. Many spore-forming bacteria were isolated from soil samples collected from oil fields in Oman. Among the isolates, an autochthonous spore-forming bacterium was found to enhance heavy oil recovery, which was identified by 16S rDNA sequencing as Paenibacillus ehimensis BS1...
2017: PloS One
https://www.readbyqxmd.com/read/28193604/telemedicine-in-pediatric-cardiology-a-scientific-statement-from-the-american-heart-association
#14
REVIEW
Gary M Satou, Karen Rheuban, Dale Alverson, Mark Lewin, Christopher Mahnke, James Marcin, Gerard R Martin, Lisa Schmitz Mazur, David J Sahn, Sanket Shah, Reed Tuckson, Catherine L Webb, Craig A Sable
No abstract text is available yet for this article.
March 14, 2017: Circulation
https://www.readbyqxmd.com/read/28164066/giant-cell-tumor-developing-in-paget-s-disease-of-bone-a-case-report-with-review-of-literature
#15
Vivek Verma, Ajay Puri, Sanket Shah, Bharat Rekhi, Ashish Gulia
INTRODUCTION: Paget's disease of bone (PDB) is a disease of elderly characterized by disorganized bone remodeling. Development of secondary neoplasm in PDB is a known but rare phenomenon. Development of giant cell tumor in PDB (GCT-PDB) is extremely rare, and little is known about its etiopathogenesis and management. We present a case report of such a development with a review of the literature and the role of various new modalities of treatment available in the management of this rare condition...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28148317/echocardiography-of-coarctation-of-the-aorta-aortic-arch-hypoplasia-and-arch-interruption-strategies-for-evaluation-of-the-aortic-arch
#16
REVIEW
Suma P Goudar, Sanket S Shah, Girish S Shirali
Aim Echocardiography is the modality of choice for the diagnosis and serial follow-up of aortic arch pathology. In this article, we review the types of obstruction of the aortic arch, various classification schemes of coarctation of the aorta and interrupted aortic arch, methodology for optimal echocardiographic imaging of the aortic arch, and key echocardiographic measurements for accurate diagnosis of obstruction and hypoplasia of the aortic arch. Finally, we will discuss the limitations of echocardiography in optimal imaging of the aortic arch and the use of other non-invasive imaging modalities such as CT or MRI to provide additional information in these cases...
December 2016: Cardiology in the Young
https://www.readbyqxmd.com/read/28135240/pericyte-degeneration-leads-to-neurovascular-uncoupling-and-limits-oxygen-supply-to-brain
#17
Kassandra Kisler, Amy R Nelson, Sanket V Rege, Anita Ramanathan, Yaoming Wang, Ashim Ahuja, Divna Lazic, Philbert S Tsai, Zhen Zhao, Yi Zhou, David A Boas, Sava Sakadžić, Berislav V Zlokovic
Pericytes are perivascular mural cells of brain capillaries. They are positioned centrally in the neurovascular unit between endothelial cells, astrocytes and neurons. This position allows them to regulate key neurovascular functions of the brain. The role of pericytes in the regulation of cerebral blood flow (CBF) and neurovascular coupling remains, however, under debate. Using loss-of-function pericyte-deficient mice, here we show that pericyte degeneration diminishes global and individual capillary CBF responses to neuronal stimuli, resulting in neurovascular uncoupling, reduced oxygen supply to the brain and metabolic stress...
March 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28125314/bisfabs-tools-for-rapidly-screening-hybridoma-iggs-for-their-activities-as-bispecific-antibodies
#18
Sanket Patke, Ji Li, Peiyin Wang, Dion Slaga, Jennifer Johnston, Sunil Bhakta, Siler Panowski, Liping L Sun, Teemu Junttila, Justin M Scheer, Diego A Ellerman
Bispecific antibodies are a growing class of therapeutic molecules. Many of the current bispecific formats require DNA engineering to convert the parental monoclonal antibodies into the final bispecific molecules. We describe here a method to generate bispecific molecules from hybridoma IgGs in 3-4 d using chemical conjugation of antigen-binding fragments (Fabs) (bisFabs). Proteolytic digestion conditions for each IgG isotype were analyzed to optimize the yield and quality of the final conjugates. The resulting bisFabs showed no significant amounts of homodimers or aggregates...
April 2017: MAbs
https://www.readbyqxmd.com/read/28118787/learning-curve-associated-with-an-automated-laparoscopic-suturing-device-compared-with-laparoscopic-suturing
#19
Steven G Leeds, Lizzy Wooley, Ganesh Sankaranarayanan, Yahya Daoud, James Fleshman, Sanket Chauhan
BACKGROUND: Laparoscopic suturing has proved to be a challenging skill to master which may prevent surgical procedures from being started, or completed, in a minimally invasive fashion. The aim of this study is to compare the learning curves between traditional laparoscopic techniques with a novel suturing device. METHODS: In this prospective single blinded nonrandomized controlled crossover study, we recruited 19 general surgery residents ranging from beginner (PGY1-2, n = 12) to advanced beginner (PGY3-5, n = 7)...
January 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/28113781/application-of-genetic-programming-gp-formalism-for-building-disease-predictive-models-from-protein-protein-interactions-ppi-data
#20
Renu Vyas, Sanket Bapat, Purva Goel, Muthukumarasamy Karthikeyan, Sanjeev S Tambe, Bhaskar D Kulkarni
Protein-protein interactions (PPIs) play a vital role in the biological processes involved in the cell functions and disease pathways. The experimental methods known to predict PPIs require tremendous efforts and the results are often hindered by the presence of a large number of false positives. Herein, we demonstrate the use of a new Genetic Programming (GP) based Symbolic Regression (SR) approach for predicting PPIs related to a disease. In a case study, a dataset consisting of one hundred and thirty five PPI complexes related to cancer was used to construct a generic PPI predicting model with good PPI prediction accuracy and generalization ability...
October 26, 2016: IEEE/ACM Transactions on Computational Biology and Bioinformatics
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