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hypertension randomized controlled trial 2016

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https://www.readbyqxmd.com/read/29068790/yogic-practices-on-oxidative-stress-and-of-antioxidant-level-a-systematic-review-of-randomized-controlled-trials
#1
Rameswar Pal, Navin Gupta
Background Many clinical trials have evaluated the oxidative stress reduction and enhancement of antioxidant status following yogic practices, but a review has not been reported earlier. Present study is designed to systematically review the effect of yogic practices on oxidative stress and antioxidant status. Content Using the MEDLINE, EMBASE SCOPEMED, and Indian database electronic searches were performed through August 2016 using the keywords yoga AND oxidative stress OR antioxidant which yielded 97 studies...
October 25, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29059396/renal-safety-of-catheter-based-renal-denervation-systematic-review-and-meta-analysis
#2
Margreet F Sanders, Johannes B Reitsma, Moira Morpey, Hendrik Gremmels, Michiel L Bots, Anna Pisano, Davide Bolignano, Carmine Zoccali, Peter J Blankestijn
Background: Catheter-based renal denervation (RDN) is a possible treatment to lower blood pressure. The invasive nature of RDN and the use of contrast agents raise concerns about potential consequent kidney damage. Our objective was to determine the change in renal function after RDN by performing a systematic review on hypertensive patients treated with RDN. Methods: A systematic search was performed in the Embase and MEDLINE databases to identify studies reporting on the effects of catheter-based RDN on renal outcome...
September 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29017595/a-series-of-n-of-1-trials-to-assess-the-therapeutic-interchangeability-of-two-enalapril-formulations-in-the-treatment-of-hypertension-in-addis-ababa-ethiopia-study-protocol-for-a-randomized-controlled-trial
#3
Chalachew Alemayehu, Geoffrey Mitchell, Abraham Aseffa, Alexandra Clavarino, James McGree, Jane Nikles
BACKGROUND: Hypertension is one of the leading causes of morbidity and mortality in Ethiopia. Treatment usually involves lifelong medication use. Enalapril is a common drug for the treatment of hypertension in Ethiopia. However, the drug is expensive and, therefore, there is limited capacity for people to afford the treatment. Locally produced Enalapril is a cost-effective solution to treat the disease. However, as local medicines regulation does not include bioequivalence tests on locally produced drugs, physicians and patients need assurance about the effectiveness and safety of local generics...
October 10, 2017: Trials
https://www.readbyqxmd.com/read/28975305/effect-of-a-community-health-worker-led-multicomponent-intervention-on-blood-pressure-control-in-low-income-patients-in-argentina-a-randomized-clinical-trial
#4
RANDOMIZED CONTROLLED TRIAL
Jiang He, Vilma Irazola, Katherine T Mills, Rosana Poggio, Andrea Beratarrechea, Jacquelyn Dolan, Chung-Shiuan Chen, Luz Gibbons, Marie Krousel-Wood, Lydia A Bazzano, Analia Nejamis, Pablo Gulayin, Marilina Santero, Federico Augustovski, Jing Chen, Adolfo Rubinstein
Importance: Despite extensive knowledge of hypertension treatment, the prevalence of uncontrolled hypertension is high and increasing in low- and middle-income countries. Objective: To test whether a community health worker-led multicomponent intervention would improve blood pressure (BP) control among low-income patients with hypertension. Design, Setting, and Participants: A cluster randomized trial was conducted in 18 centers for primary health care within a national public system providing free medications and health care to uninsured patients in Argentina...
September 19, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28973174/low-dose-vs-standard-dose-alteplase-for-patients-with-acute-ischemic-stroke-secondary-analysis-of-the-enchanted-randomized-clinical-trial
#5
Xia Wang, Thompson G Robinson, Tsong-Hai Lee, Qiang Li, Hisatomi Arima, Philip M Bath, Laurent Billot, Joseph Broderick, Andrew M Demchuk, Geoffrey Donnan, Jong S Kim, Pablo Lavados, Richard I Lindley, Sheila O Martins, Veronica V Olavarria, Jeyaraj D Pandian, Mark W Parsons, Octavio M Pontes-Neto, Stefano Ricci, Vijay K Sharma, Nguyen H Thang, Ji-Guang Wang, Mark Woodward, Craig S Anderson, John Chalmers
Importance: A lower dose of intravenous alteplase appears to be a safer treatment option than the standard dose, reducing the risk of symptomatic intracerebral hemorrhage. There is uncertainty, however, over how this effect translates into an overall clinical benefit for patients with acute ischemic stroke (AIS). Objective: To assess whether older, Asian, or severely affected patients with AIS who are considered at high risk of thrombolysis may benefit more from low-dose rather than standard-dose alteplase treatment...
November 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28957682/illness-burden-and-physical-outcomes-associated-with-collaborative-care-in-patients-with-comorbid-depressive-disorder-in-chronic-medical-conditions-a-systematic-review-and-meta-analysis
#6
Jonna F van Eck van der Sluijs, Hilde Castelijns, Vera Eijsbroek, Cees A Th Rijnders, Harm W J van Marwijk, Christina M van der Feltz-Cornelis
OBJECTIVE: Collaborative care (CC) improves depressive symptoms in people with comorbid depressive disorder in chronic medical conditions, but its effect on physical symptoms has not yet systematically been reviewed. This study aims to do so. METHODS: Systematic review and meta-analysis was conducted using PubMed, the Cochrane Library, and the European and US Clinical Trial Registers. Eligible studies included randomized controlled trials (RCTs) of CC compared to care as usual (CAU), in primary care and general hospital setting, reporting on physical and depressive symptoms as outcomes...
September 13, 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28933305/epidemiology-of-diabetes-mellitus-in-the-united-arab-emirates
#7
Hira Abdul Razzak, Alya Harbi, Wael Shelpai, Ahmad Qawas
Background/ Objective: Diabetes mellitus is a non-communicable disease which has become a major global public health issue. This systematic review summarized epidemiological studies related to the prevalence, risk factors, complications, incidence, knowledge, attitude and practices of Diabetes Mellitus (DM) among Arab population in the United Arab Emirates (UAE). METHOD: PubMed, Scopus databases, Science direct, Wiley online library, and other local journals were searched to identify relevant literature using appropriate keywords to retrieve studies conducted in the UAE...
September 20, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28931031/reducing-therapeutic-misconception-a-randomized-intervention-trial-in-hypothetical-clinical-trials
#8
RANDOMIZED CONTROLLED TRIAL
Paul P Christopher, Paul S Appelbaum, Debbie Truong, Karen Albert, Louise Maranda, Charles Lidz
BACKGROUND: Participants in clinical trials frequently fail to appreciate key differences between research and clinical care. This phenomenon, known as therapeutic misconception, undermines informed consent to clinical research, but to date there have been no effective interventions to reduce it and concerns have been expressed that to do so might impede recruitment. We determined whether a scientific reframing intervention reduces therapeutic misconception without significantly reducing willingness to participate in hypothetical clinical trials...
2017: PloS One
https://www.readbyqxmd.com/read/28923789/assessing-the-efficacy-and-safety-of-an-11%C3%AE-hydroxysteroid-dehydrogenase-type-1-inhibitor-azd4017-in-the-idiopathic-intracranial-hypertension-drug-trial-iih-dt-clinical-methods-and-design-for-a-phase-ii-randomized-controlled-trial
#9
Keira Annie Markey, Ryan Ottridge, James L Mitchell, Caroline Rick, Rebecca Woolley, Natalie Ives, Peter Nightingale, Alexandra J Sinclair
BACKGROUND: Idiopathic intracranial hypertension (IIH) is a condition with few effective management options. So far, there have been no randomized controlled trials evaluating new treatments in IIH. OBJECTIVES: The purpose of this paper is to outline the trial design for the Idiopathic Intracranial Hypertension Drug Trial (IIH:DT), assessing an innovative medical treatment in IIH and the rationale for the chosen trial methodology. METHODS: IIH:DT is a phase II double-blind randomized placebo-controlled trial recruiting 30 female participants with active IIH (intracranial pressure >25cm H2 O and papilledema)...
September 18, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28919201/macitentan-for-the-treatment-of-inoperable-chronic-thromboembolic-pulmonary-hypertension-merit-1-results-from-the-multicentre-phase-2-randomised-double-blind-placebo-controlled-study
#10
Hossein-Ardeschir Ghofrani, Gérald Simonneau, Andrea M D'Armini, Peter Fedullo, Luke S Howard, Xavier Jaïs, David P Jenkins, Zhi-Cheng Jing, Michael M Madani, Nicolas Martin, Eckhard Mayer, Kelly Papadakis, Dominik Richard, Nick H Kim
BACKGROUND: Macitentan is beneficial for long-term treatment of pulmonary arterial hypertension. The microvasculopathy of chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension are similar. METHODS: The phase 2, double-blind, randomised, placebo-controlled MERIT-1 trial assessed macitentan in 80 patients with CTEPH adjudicated as inoperable. Patients identified as WHO functional class II-IV with a pulmonary vascular resistance (PVR) of at least 400 dyn·s/cm(5) and a walk distance of 150-450 m in 6 min were randomly assigned (1:1), via an interactive voice/web response system, to receive oral macitentan (10 mg once a day) or placebo...
October 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28873137/association-between-more-intensive-vs-less-intensive-blood-pressure-lowering-and-risk-of-mortality-in-chronic-kidney-disease-stages-3-to-5-a-systematic-review-and-meta-analysis
#11
REVIEW
Rakesh Malhotra, Hoang Anh Nguyen, Oscar Benavente, Mihriye Mete, Barbara V Howard, Jonathan Mant, Michelle C Odden, Carmen A Peralta, Alfred K Cheung, Girish N Nadkarni, Ruth L Coleman, Rury R Holman, Alberto Zanchetti, Ruth Peters, Nigel Beckett, Jan A Staessen, Joachim H Ix
Importance: Trials in patients with hypertension have demonstrated that intensive blood pressure (BP) lowering reduces the risk of cardiovascular disease and all-cause mortality but may increase the risk of chronic kidney disease (CKD) incidence and progression. Whether intensive BP lowering is associated with a mortality benefit in patients with prevalent CKD remains unknown. Objectives: To conduct a systematic review and meta-analysis of randomized clinical trials (RCTs) to investigate if more intensive compared with less intensive BP control is associated with reduced mortality risk in persons with CKD stages 3 to 5...
October 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28865498/-analysis-of-the-cochrane-review-pharmacotherapy-for-hyperuricemia-in-hypertensive-patients-cochrane-database-syst-rev-2017-4-cd008652
#12
Miguel Bigotte Vieira, Rute Baeta Baptista, João Costa, António Vaz-Carneiro
Arterial hypertension is a public health problem that affects approximately 25% of the world's adult population. The association between hypertension and hyperuricemia has been shown on epidemiological and experimental studies. However, it is unclear whether lowering serum uric acid might lower blood pressure. This Cochrane systematic review - a revised edition of a previously published one - intended as primary objective to evaluate the effect of hypouricemic drugs in patients with primary hypertension or prehypertension...
May 31, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28862931/cardiovascular-adverse-events-in-patients-with-cancer-treated-with-bevacizumab-a-meta-analysis-of-more-than-20%C3%A2-000-patients
#13
REVIEW
Matthias Totzeck, Raluca Ileana Mincu, Tienush Rassaf
BACKGROUND: The monoclonal antibody bevacizumab effectively inhibits angiogenesis in several types of cancers by blocking vascular endothelial growth factor. However, life-threatening cardiovascular adverse effects could limit its use and may warrant specific follow-up strategies. METHODS AND RESULTS: We systematically searched MEDLINE, Cochrane, EMBASE, and Web of Science for randomized controlled trials published until November 2016 that assessed patients with cancer treated with or without bevacizumab in addition to standard chemotherapy...
August 10, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28858984/effects-of-blood-pressure-lowering-treatment-on-outcome-incidence-12-effects-in-individuals-with-high-normal-and-normal-blood-pressure-overview-and-meta-analyses-of-randomized-trials
#14
Costas Thomopoulos, Gianfranco Parati, Alberto Zanchetti
BACKGROUND: It is currently unknown whether individuals with SBP/DBP values in the ranges 120-139/80-89 mmHg, usually defined as with prehypertension or high-normal and normal blood pressure (BP), benefit from BP-lowering treatment and whether benefits in these individuals depend on the level of their cardiovascular risk. OBJECTIVES: Meta-analyzing all available data from randomized controlled trials (RCTs) about the effects on cardiovascular outcomes of BP-lowering treatment in individuals with normal or high-normal BP values in absence of baseline antihypertensive drugs and free from a recent myocardial infarction, left ventricular dysfunction and heart failure...
November 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28842086/comparison-of-time-to-operation-and-efficacies-of-ultrasound-guided-nerve-block-and-general-anesthesia-in-emergency-external-fixation-of%C3%A2-lower-leg-fractures-ao-42-43-44
#15
Chan Kang, Sang-Bum Kim, Youn-Moo Heo, You-Gun Won, Byung-Hak Oh, June-Bum Jun, Gi-Soo Lee
The present randomized controlled trial evaluated the usefulness of ultrasound (US)-guided nerve block (NB) for emergency external fixation of lower leg fractures, by investigating the time required before surgery and the clinical results stratified by the anesthesia method (US-guided NB or general anesthesia [GA]). From June 2014 to April 2016, 40 patients who had undergone emergency surgery for external fixator application were enrolled in the present study. We measured the lead time before the start of surgery after the decision to perform emergency surgery in both groups...
September 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28826680/patient-characteristics-associated-with-quality-of-colonoscopy-preparation-a-systematic-review-and-meta-analysis
#16
Kunjal Gandhi, Christina Tofani, Carly Sokach, Devin Patel, David Kastenberg, Constantine Daskalakis
BACKGROUND & AIMS: Some features of patients are associated with inadequate bowel preparation, which reduces the effectiveness of colonoscopy examination. We performed a systematic review and meta-analysis of the association between patients' sociodemographic characteristics, health conditions, and medications with inadequate bowel preparation. METHODS: We searched the PubMed, Scopus, and Cochrane Review databases for randomized controlled trials and cohort (prospective and retrospective), case-control, and cross-sectional studies published through March 2016...
August 18, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28814305/blood-pressure-lowering-effect-of-shinrin-yoku-forest-bathing-a-systematic-review-and-meta-analysis
#17
Yuki Ideno, Kunihiko Hayashi, Yukina Abe, Kayo Ueda, Hiroyasu Iso, Mitsuhiko Noda, Jung-Su Lee, Shosuke Suzuki
BACKGROUND: Shinrin-yoku (experiencing the forest atmosphere or forest bathing) has received increasing attention from the perspective of preventive medicine in recent years. Some studies have reported that the forest environment decreases blood pressure. However, little is known about the possibility of anti-hypertensive applications of Shinrin-yoku. This study aimed to evaluate preventive or therapeutic effects of the forest environment on blood pressure. METHODS: We systematically reviewed the medical literature and performed a meta-analysis...
August 16, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28807582/comparative-efficacy-of-angiotensin-ii-antagonists-in-essential-hypertension-systematic-review-and-network-meta-analysis-of-randomised-controlled-trials
#18
Bernice Tsoi, Leo E Akioyamen, Ashley Bonner, Claudia Frankfurter, Mitchell Levine, Eleanor Pullenayegum, Ron Goeree, Daria O'Reilly
BACKGROUND: Evidence on the long-term clinical benefits of individual members of angiotensin II receptor blockers is limited given the lack of head-to-head studies. We conducted a network meta-analysis to determine the comparative efficacy of different members within this drug class with respect to outcomes of (i) blood pressure reduction (at 24 and 52 weeks) and (ii) prevention of cardiovascular disease (>104 weeks). METHODS: A systematic literature review was conducted - Protocol registration: (PROSPERO - CRD42014007067) - to identify relevant literature from the following databases: Cochrane Library, PubMed, MEDLINE and Embase; searched from inception to July 2016...
July 14, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28802605/laparoscopic-cholecystectomy-under-neuraxial-anesthesia-compared-with-general-anesthesia-systematic-review-and-meta-analyses
#19
REVIEW
Marcelo A Longo, Bárbara T Cavalheiro, Getúlio R de Oliveira Filho
BACKGROUND: Pneumoperitoneum during laparoscopic cholecystectomy (LC) can cause hypercapnia, hypoxemia, hemodynamic changes and shoulder pain. General anesthesia (GA) enables the control of intraoperative pain and ventilation. The need for GA has been questioned by studies suggesting that neuraxial anesthesia (NA) is adequate for LC. STUDY OBJECTIVE: To quantify the prevalence of intraoperative pain and to verify whether evidence on the maintenance of ventilation, circulation and surgical anesthesia during NA compared with GA is consistent...
September 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28769100/resistance-training-alone-reduces-systolic-and-diastolic-blood-pressure-in-prehypertensive-and-hypertensive-individuals-meta-analysis
#20
Evitom Corrêa de Sousa, Odilon Abrahin, Ana Lorena Lima Ferreira, Rejane Pequeno Rodrigues, Erik Artur Cortinhas Alves, Rodolfo Paula Vieira
The purpose of this study was to evaluate the effects of resistance training alone on the systolic and diastolic blood pressure in prehypertensive and hypertensive individuals. Our meta-analysis, followed the guidelines of PRISMA. The search for articles was realized by November 2016 using the following electronic databases: BIREME, PubMed, Cochrane Library, LILACS and SciELO and a search strategy that included the combination of titles of medical affairs and terms of free text to the key concepts: 'hypertension' 'hypertensive', 'prehypertensive', 'resistance training', 'strength training', and 'weight-lifting'...
November 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
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