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hypertension randomized controlled trial 2016

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https://www.readbyqxmd.com/read/28716847/nonnutritive-sweeteners-and-cardiometabolic-health-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-and-prospective-cohort-studies
#1
Meghan B Azad, Ahmed M Abou-Setta, Bhupendrasinh F Chauhan, Rasheda Rabbani, Justin Lys, Leslie Copstein, Amrinder Mann, Maya M Jeyaraman, Ashleigh E Reid, Michelle Fiander, Dylan S MacKay, Jon McGavock, Brandy Wicklow, Ryan Zarychanski
BACKGROUND: Nonnutritive sweeteners, such as aspartame, sucralose and stevioside, are widely consumed, yet their long-term health impact is uncertain. We synthesized evidence from prospective studies to determine whether routine consumption of non-nutritive sweeteners was associated with long-term adverse cardiometabolic effects. METHODS: We searched MEDLINE, Embase and Cochrane Library (inception to January 2016) for randomized controlled trials (RCTs) that evaluated interventions for nonnutritive sweeteners and prospective cohort studies that reported on consumption of non-nutritive sweeteners among adults and adolescents...
July 17, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28707603/ginseng-for-the-treatment-of-hypertension-a-systematic-review-and-meta-analysis-of-double-blind-randomized-placebo-controlled-trials
#2
Hye Won Lee, Hyun- Ja Lim, Ji Hee Jun, Jiae Choi, Myeong Soo Lee
BACKGROUND: Evidence of ginseng for reducing blood pressure (BP) in hypertensive patients is controversial. This systematic review updated the previous reviews and evidence for it. METHODS: Ten databases were searched from their inception through October 2016, without language restriction. Randomized clinical trials (RCTs) were included if any types of ginseng were tested as the sole treatment or as an adjunct to other treatments for pre-hypertension or hypertension...
July 12, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28697259/behavioral-counseling-to-promote-a-healthful-diet-and-physical-activity-for-cardiovascular-disease-prevention-in-adults-without-known-cardiovascular-disease-risk-factors-updated-evidence-report-and-systematic-review-for-the-us-preventive-services-task-force
#3
REVIEW
Carrie D Patnode, Corrine V Evans, Caitlyn A Senger, Nadia Redmond, Jennifer S Lin
Importance: Unhealthful dietary patterns, low levels of physical activity, and high sedentary time increase the risk of cardiovascular disease. Objective: To systematically review the evidence on the benefits and harms of behavioral counseling for the primary prevention of cardiovascular disease in adults without known cardiovascular risk factors to inform the US Preventive Services Task Force. Data Sources: MEDLINE, PubMed, Cochrane Central Register of Controlled Trials, and PsycINFO for studies published in the English language between January 1, 2013, and May 25, 2016, and ongoing surveillance in targeted publications through March 24, 2017...
July 11, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28680574/chronic-use-of-pah-specific-therapy-in-world-health-organization-group-iii-pulmonary-hypertension-a-systematic-review-and-meta-analysis
#4
Kurt W Prins, Sue Duval, Jeremy Markowitz, Marc Pritzker, Thenappan Thenappan
Pulmonary hypertension (PH) complicating chronic obstructive pulmonary disease (COPD-PH) and interstitial lung disease (ILD-PH) (World Health Organization [WHO] Group III PH) increases medical costs and reduces survival. Despite limited data, many clinicians are using pulmonary arterial hypertension (PAH)-specific therapy to treat WHO Group III PH patients. To further investigate the utility of PAH-specific therapy in WHO Group III PH, we performed a systematic review and meta-analysis. Relevant studies from January 2000 through May 2016 were identified in the MEDLINE, EMBASE, and COCHRANE electronic databases and www...
March 2017: Pulmonary Circulation
https://www.readbyqxmd.com/read/28659171/comparison-of-endoscopic-evacuation-stereotactic-aspiration-and-craniotomy-for-the-treatment-of-supratentorial-hypertensive-intracerebral-haemorrhage-study-protocol-for-a-randomised-controlled-trial
#5
Xinghua Xu, Yi Zheng, Xiaolei Chen, Fangye Li, Huaping Zhang, Xin Ge
BACKGROUND: Hypertensive intracerebral haemorrhage (HICH) is the most common form of haemorrhagic stroke with the highest morbidity and mortality of all stroke types. The choice of surgical or conservative treatment for patients with HICH remains controversial. In recent years, minimally invasive surgeries, such as endoscopic evacuation and stereotactic aspiration, have been attempted for haematoma removal and offer promise. However, research evidence on the benefits of endoscopic evacuation or stereotactic aspiration is still insufficient...
June 28, 2017: Trials
https://www.readbyqxmd.com/read/28649145/do-ssris-and-snris-reduce-the-frequency-and-or-severity-of-hot-flashes-in-menopausal-women
#6
Chris Stubbs, Lisa Mattingly, Steven A Crawford, Elizabeth A Wickersham, Jessica L Brockhaus, Laine H McCarthy
CLINICAL QUESTION: In menopausal women who experience regular hot flashes, does treatment with selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) reduce the frequency and/or severity of hot flashes? ANSWER: Yes. Review of the literature suggests that treatment with SSRIs or SNRIs reduces the frequency and severity of hot flashes in menopausal and post-menopausal women. Studies demonstrated that paroxetine (Paxil), citalopram (Celexa) and escitolapram (Lexapro) were the most effective SSRIs, and venlafaxine (Effexor) was the most effective first line SNRI, with desvenlafaxine as a second option...
May 2017: Journal of the Oklahoma State Medical Association
https://www.readbyqxmd.com/read/28639575/account-for-clinical-heterogeneity-in-assessment-of-catheter-based-renal-denervation-among-resistant-hypertension-patients-subgroup-meta-analysis
#7
Xiao-Han Chen, Sehee Kim, Xiao-Xi Zeng, Zhi-Bing Chen, Tian-Lei Cui, Zhang-Xue Hu, Yi Li, Ping Fu
BACKGROUND: Catheter-based renal denervation (RDN) is a novel treatment for resistant hypertension (RH). A recent meta-analysis reported that RDN did not significantly reduce blood pressure (BP) based on the pooled effects with mild to severe heterogeneity. The aim of the present study was to identify and reduce clinical sources of heterogeneity and reassess the safety and efficacy of RDN within the identified homogeneous subpopulations. METHODS: This was a meta-analysis of 9 randomized clinical trials (RCTs) among patients with RH up to June 2016...
July 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28606229/-early-postnatal-application-of-glucocorticoids-for-preventing-bronchopulmonary-dysplasia-in-preterm-infants-a-meta-analysis
#8
Feng-Juan Ji, Yong Yin, Juan Xu, Li-Xia Zhao, Ya-Juan Zhou, Lei Zhu
OBJECTIVE: To study the clinical effect and safety of early postnatal application of glucocorticoids in the prevention of bronchopulmonary dysplasia (BPD) in preterm infants. METHODS: The databases including PubMed, Cochrane Library, Embase, CNKI, Wanfang Data, and VIP were comprehensively searched for articles on early postnatal application of glucocorticoids in the prevention of BPD in preterm infants published up to June 2016. Review Manager 5.3 was used for the Meta analysis of 16 randomized controlled trials (RCTs) that met the inclusion criteria...
June 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28606184/multicomponent-intervention-versus-usual-care-for-management-of-hypertension-in-rural-bangladesh-pakistan-and-sri-lanka-study-protocol-for-a-cluster-randomized-controlled-trial
#9
Tazeen H Jafar, Imtiaz Jehan, H Asita de Silva, Aliya Naheed, Mihir Gandhi, Pryseley Assam, Eric A Finkelstein, Helena Legido Quigley, Marcel Bilger, Aamir Hameed Khan, John David Clemens, Shah Ebrahim, Elizabeth L Turner, Anuradhani Kasturiratne
BACKGROUND: High blood pressure (BP) is the leading attributable risk for cardiovascular disease (CVD). In rural South Asia, hypertension continues to be a significant public health issue with sub-optimal BP control rates. The goal of the trial is to compare a multicomponent intervention (MCI) to usual care to evaluate the effectiveness and cost-effectiveness of the MCI for lowering BP among adults with hypertension in rural communities in Bangladesh, Pakistan and Sri Lanka. METHODS/DESIGN: This study is a stratified, cluster randomized controlled trial with a qualitative component for evaluation of processes and stakeholder feedback...
June 12, 2017: Trials
https://www.readbyqxmd.com/read/28578691/acute-and-chronic-effects-of-aerobic-exercise-on-blood-pressure-in-resistant-hypertension-study-protocol-for-a-randomized-controlled-trial
#10
L S Nascimento, A C Santos, Jms Lucena, Lgo Silva, Aem Almeida, M S Brasileiro-Santos
BACKGROUND: Resistant hypertension is a specific condition that affects approximately 10% of subjects with hypertension, and is characterized by persistently high blood pressure levels even using therapy of three or more antihypertensive agents or with blood pressure control using therapy with four or more antihypertensive agents. Changes in lifestyle, such as physical exercise, are indicated for controlling blood pressure. However, investigating studies about this therapy in individuals with resistant hypertension are few...
June 2, 2017: Trials
https://www.readbyqxmd.com/read/28566151/mobile-health-as-a-viable-strategy-to-enhance-stroke-risk-factor-control-a-systematic-review-and-meta-analysis
#11
REVIEW
Shimeng Liu, Wuwei Feng, Pratik Y Chhatbar, Yumei Liu, Xunming Ji, Bruce Ovbiagele
BACKGROUND: With the rapid growth worldwide in cell-phone use, Internet connectivity, and digital health technology, mobile health (mHealth) technology may offer a promising approach to bridge evidence-treatment gaps in stroke prevention. We aimed to evaluate the effectiveness of mHealth for stroke risk factor control through a systematic review and meta-analysis. METHODS: We searched PubMed from January 1, 2000 to May 17, 2016 using the following keywords: mobile health, mHealth, short message, cellular phone, mobile phone, stroke prevention and control, diabetes mellitus, hypertension, hyperlipidemia and smoking cessation...
July 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28545514/a-coordinated-pcp-cardiologist-telemedicine-model-pctm-in-china-s-community-hypertension-care-study-protocol-for-a-randomized-controlled-trial
#12
Lei Xu, Wei-Yi Fang, Fu Zhu, Hong-Guang Zhang, Kai Liu
BACKGROUND: Hypertension is a major risk factor for cardiovascular disease, and its control rate has remained low worldwide. Studies have found that telemonitoring blood pressure (BP) helped control hypertension in randomized controlled trials. However, little is known about its effect in a structured primary care model in which primary care physicians (PCPs) are partnering with cardiology specialists in electronic healthcare data sharing and medical interventions. This study aims to identify the effects of a coordinated PCP-cardiologist model that applies telemedicine tools to facilitate community hypertension control in China...
May 25, 2017: Trials
https://www.readbyqxmd.com/read/28529532/the-effect-of-three-different-meditation-exercises-on-hypertension-a-network-meta-analysis
#13
Hongchang Yang, Xueping Wu, Min Wang
We aimed to use the pairwise and network meta-analysis to estimate the effects of different meditation exercises on the control of systolic blood pressure (SBP) and diastolic blood pressure (DBP). Randomized controlled trials (RCTs) were retrieved from PubMed and Embase up to June 2016, which are published in English and reported on meditation exercise for hypertensive patients. Risks of bias assessment of the included studies were assessed by Cochrane Collaboration Recommendations and network meta-analysis was performed by ADDIS...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28515115/impact-of-antihypertensive-treatment-on-maternal-and-perinatal-outcomes-in-pregnancy-complicated-by-chronic-hypertension-a%C3%A2-systematic-review-and-meta-analysis
#14
REVIEW
Louise M Webster, Frances Conti-Ramsden, Paul T Seed, Andrew J Webb, Catherine Nelson-Piercy, Lucy C Chappell
BACKGROUND: Chronic hypertension complicates around 3% of all pregnancies. There is evidence that treating severe hypertension reduces maternal morbidity. This study aimed to systematically review randomized controlled trials of antihypertensive agents treating chronic hypertension in pregnancy to determine the effect of this intervention. METHODS AND RESULTS: Medline (via OVID), Embase (via OVID) and the Cochrane Trials Register were searched from their earliest entries until November 30, 2016...
May 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28511964/evidence-on-multimorbidity-from-definition-to-intervention-an-overview-of-systematic-reviews
#15
REVIEW
Xiaolin Xu, Gita D Mishra, Mark Jones
The increasing challenge of multiple chronic diseases (multimorbidity) requires more evidence-based knowledge and effective practice. In order to better understand the existing evidence on multimorbidity, we performed a systematic review of systematic reviews on multimorbidity with pre-established search strategies and exclusion criteria by searching multiple databases and grey literature. Of 8006 articles found, 53 systematic reviews (including meta-analysis and qualitative research synthesis performed in some reviews) that stated multimorbidity as the main focus were included, with 79% published during 2013-2016...
August 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28509399/association-of-renin-angiotensin-antagonists-with-adverse-perioperative-events-in-patients-undergoing-elective-orthopaedic-surgery-a-case-control-study
#16
Amith Zainudheen, Ian A Scott, Xenia Caney
BACKGROUND: Renin angiotensin antagonists (RAAs) may block protective vasopressor responses during surgery. Evidence linking RAAs with intraoperative hypotension and perioperative adverse events is conflicting. METHODS: Retrospective case-control study of 258 consecutive patients who underwent elective total knee or hip replacement between January 1(st) 2013 and August 31(st) 2016, and who were chronically prescribed a single blood pressure lowering agent up to the time of surgery...
May 16, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28446526/impact-of-different-dietary-approaches-on-blood-pressure-in-hypertensive-and-prehypertensive-patients-protocol-for-a-systematic-review-and-network-meta-analysis
#17
Lukas Schwingshackl, Anna Chaimani, Georg Hoffmann, Carolina Schwedhelm, Heiner Boeing
INTRODUCTION: Lifestyle modification is one of the cornerstones in the management of hypertension. According to the most recent guidelines by the American Heart Association, all patients with hypertension should adopt the following dietary advices: increased consumption of fresh fruits, vegetables, low-fat dairy products and sodium reduction. The aim of the present study is to assess the efficacy of different dietary approaches on systolic and diastolic blood pressure in patients with hypertension and high normal blood pressure in a systematic review including a pairwise and network meta-analysis of randomised trials...
April 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/28439881/effect-of-cocoa-on-blood-pressure
#18
REVIEW
Karin Ried, Peter Fakler, Nigel P Stocks
BACKGROUND: High blood pressure is an important risk factor for cardiovascular disease, contributing to about 50% of cardiovascular events worldwide and 37% of cardiovascular-related deaths in Western populations. Epidemiological studies suggest that cocoa-rich products reduce the risk of cardiovascular disease. Flavanols found in cocoa have been shown to increase the formation of endothelial nitric oxide which promotes vasodilation and therefore blood pressure reduction. Here we update previous meta-analyses on the effect of cocoa on blood pressure...
April 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28419159/oral-potassium-supplementation-for-management-of-essential-hypertension-a-meta-analysis-of-randomized-controlled-trials
#19
Jalal Poorolajal, Fatemeh Zeraati, Ali Reza Soltanian, Vida Sheikh, Elham Hooshmand, Akram Maleki
IMPORTANCE: Increased dietary potassium intake is thought to be associated with low blood pressure (BP). Whether potassium supplementation may be used as an antihypertensive agent is a question that should be answered. OBJECTIVE: To assess the effect of oral potassium supplementation on blood pressure in patients with primary hypertension. SEARCH METHODS: We searched Medline, Web of Science, Scopus, Cochrane Central Register of Controlled Trials until October 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28416755/efficacy-and-safety-of-braf-inhibition-alone-versus-combined-braf-and-mek-inhibition-in-melanoma-a-meta-analysis-of-randomized-controlled-trials
#20
REVIEW
Mengdong Liu, Xuekang Yang, Jiaqi Liu, Bin Zhao, Weixia Cai, Yan Li, Dahai Hu
Recent clinical studies have shown that combination therapy of BRAF and MEK inhibition provides more survival benefit than BRAF inhibition monotherapy. However, the adverse events due to BRAF and MEK inhibitors impact the physical comfort and social life of patients. Thus, in this study we have undertaken a meta-analysis of randomized controlled trials to compare the efficacy and adverse events risk between monotherapy and combination therapy. We identified the relevant studies by searching PubMed, EMBASE and Google scholar databases, between the year January 2000 and May 2016...
May 9, 2017: Oncotarget
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