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heart failure randomized controlled trial 2016

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https://www.readbyqxmd.com/read/27866027/cardiovascular-outcomes-with-sodium-glucose-cotransporter-2-inhibitors-in-patients-with-type-ii-diabetes-mellitus-a-meta-analysis-of-placebo-controlled-randomized-trials
#1
Marwan Saad, Ahmed N Mahmoud, Islam Y Elgendy, Ahmed Abuzaid, Amr F Barakat, Akram Y Elgendy, Mohammad Al-Ani, Amgad Mentias, Ramez Nairooz, Anthony A Bavry, Debabrata Mukherjee
BACKGROUND: The impact of sodium-glucose cotransporter-2 (SGLT-2) inhibitors on cardiovascular outcomes in patients with type II diabetes mellitus (DM) is not well established. METHODS: We searched electronic databases from inception through July 2016 for randomized, placebo-controlled trials, involving SGLT-2 inhibitors. Fixed-effects summary odds ratios (OR) were constructed using Peto model. RESULTS: Eighty-one trials with a total of 37,195 patients were included...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27827525/the-clinical-effectiveness-of-telemedicine-for-chronic-heart-failure-a-systematic-review-and-meta-analysis
#2
Mao H Lin, Wo L Yuan, Tu C Huang, Hai F Zhang, Jing T Mai, Jing F Wang
INTRODUCTION: Telemedicine interventions had been found to effectively reduce all-cause mortality and hospital admission rate of the patients with heart failure (HF). This study aims to update the clinical benefit of telemedicine for HF. EVIDENCE ACQUISITION: Literature databases (updated to June 30, 2016) were searched for randomized controlled trials for HF patients, in which the participants were randomized into telemedicine group (tele-transmission, telephone-supported care, and implantable monitoring) or the usual standard care group...
November 9, 2016: Minerva Medica
https://www.readbyqxmd.com/read/27764523/benzodiazepines-for-the-relief-of-breathlessness-in-advanced-malignant-and-non-malignant-diseases-in-adults
#3
REVIEW
Steffen T Simon, Irene J Higginson, Sara Booth, Richard Harding, Vera Weingärtner, Claudia Bausewein
BACKGROUND: This is an updated version of the original Cochrane review published in Issue 1, 2010, on 'Benzodiazepines for the relief of breathlessness in advanced malignant and non-malignant diseases in adults'. Breathlessness is one of the most common symptoms experienced in the advanced stages of malignant and non-malignant disease. Benzodiazepines are widely used for the relief of breathlessness in advanced diseases and are regularly recommended in the literature. At the time of the previously published Cochrane review, there was no evidence for a beneficial effect of benzodiazepines for the relief of breathlessness in people with advanced cancer and chronic obstructive pulmonary disease (COPD)...
October 20, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27754167/sy-12-3-are-ras-inhibitors-necessary-for-all-patients-with-diabetes-and-chronic-kidney-disease
#4
Shokei Kim-Mitsuyama
There is accumulating evidence that RAS inhibitors not only reduce blood pressure, but also exert pleiotropic effects, including a renoprotective effect, amelioration of insulin resistance, reduction in onset of diabetes, and suppression of cardiovascular remodelling,. However, the definite benefit of RAS inhibition in treatment of hypertension with CKD or DM is not conclusive. We previously performed the OlmeSartan and Calcium Antagonists Randomized (OSCAR) study comparing the preventive effect of high-dose ARB therapy versus ARB plus CCB combination therapy on cardiovascular morbidity and mortality in 1164 Japanese elderly hypertensive patients with baseline type 2 diabetes and/or CVD (Am J Med (2012))...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27749986/insulin-secretagogues-for-prevention-or-delay-of-type-2-diabetes-mellitus-and-its-associated-complications-in-persons-at-increased-risk-for-the-development-of-type-2-diabetes-mellitus
#5
REVIEW
Bianca Hemmingsen, David Peick Sonne, Maria-Inti Metzendorf, Bernd Richter
BACKGROUND: The projected rise in the incidence of type 2 diabetes mellitus (T2DM) could develop into a substantial health problem worldwide. Whether insulin secretagogues (sulphonylureas and meglitinide analogues) are able to prevent or delay T2DM and its associated complications in people at risk for the development of T2DM is unknown. OBJECTIVES: To assess the effects of insulin secretagogues on the prevention or delay of T2DM and its associated complications in people with impaired glucose tolerance, impaired fasting blood glucose, moderately elevated glycosylated haemoglobin A1c (HbA1c) or any combination of these...
October 17, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27643122/sy-12-3-are-ras-inhibitors-necessary-for-all-patients-with-diabetes-and-chronic-kidney-disease
#6
Shokei Kim-Mitsuyama
There is accumulating evidence that RAS inhibitors not only reduce blood pressure, but also exert pleiotropic effects, including a renoprotective effect, amelioration of insulin resistance, reduction in onset of diabetes, and suppression of cardiovascular remodelling,. However, the definite benefit of RAS inhibition in treatment of hypertension with CKD or DM is not conclusive. We previously performed the OlmeSartan and Calcium Antagonists Randomized (OSCAR) study comparing the preventive effect of high-dose ARB therapy versus ARB plus CCB combination therapy on cardiovascular morbidity and mortality in 1164 Japanese elderly hypertensive patients with baseline type 2 diabetes and/or CVD (Am J Med (2012))...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27595688/rationale-design-and-baseline-characteristics-of-the-danish-randomized-controlled-multicenter-study-to-assess-the-efficacy-of-implantable-cardioverter-defibrillators-in-patients-with-non-ischemic-systolic-heart-failure-on-mortality-danish
#7
Jens Jakob Thune, Steen Pehrson, Jens Cosedis Nielsen, Jens Haarbo, Lars Videbæk, Eva Korup, Gunnar Jensen, Per Hildebrandt, Flemming Hald Steffensen, Niels Eske Bruun, Hans Eiskjær, Axel Brandes, Anna Margrethe Thøgersen, Kenneth Egstrup, Jesper Hastrup-Svendsen, Dan Eik Høfsten, Christian Torp-Pedersen, Lars Køber
BACKGROUND: The effect of an implantable cardioverter defibrillator (ICD) in patients with symptomatic systolic heart failure (HF) caused by coronary artery disease is well documented. However, the effect of primary prophylactic ICDs in patients with systolic HF not due to coronary artery disease is much weaker. In addition, HF management has improved, since the landmark ICD trials and a large proportion of patients now receive cardiac resynchronization therapy (CRT) where the effect of ICD treatment is unknown...
September 2016: American Heart Journal
https://www.readbyqxmd.com/read/27552476/mediterranean-diet-and-life-expectancy-beyond-olive-oil-fruits-and-vegetables
#8
Miguel A Martinez-Gonzalez, Nerea Martin-Calvo
PURPOSE OF REVIEW: The recent relevant evidence of the effects of the Mediterranean diet (MedDiet) and lifestyle on health (2015 and first months of 2016). RECENT FINDINGS: Large observational prospective epidemiological studies with adequate control of confounding and two large randomized trials support the benefits of the Mediterranean dietary pattern to increase life expectancy, reduce the risk of major chronic disease, and improve quality of life and well-being...
November 2016: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/27488764/nitrates-for-the-prevention-of-cardiac-morbidity-and-mortality-in-patients-undergoing-non-cardiac-surgery
#9
REVIEW
Na Zhao, Jin Xu, Balwinder Singh, Xuerong Yu, Taixiang Wu, Yuguang Huang
BACKGROUND: Cardiac complications are not uncommon in patients undergoing non-cardiac surgery, especially in patients with coronary artery disease (CAD) or at high risk of CAD. Perioperative cardiac complications can lead to mortality and morbidity, as well as higher costs for patient care. Nitrates, which are among the most commonly used cardiovascular drugs, perform the function of decreasing cardiac preload while improving cardiac blood perfusion. Sometimes, nitrates are administered to patients undergoing non-cardiac surgery to reduce the incidence of cardiac complications, especially for patients with CAD...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27422639/a-single-center-randomized-controlled-trial-investigating-the-efficacy-of-a-mhealth-ecg-technology-intervention-to-improve-the-detection-of-atrial-fibrillation-the-iheart-study-protocol
#10
Kathleen T Hickey, Nicole R Hauser, Laura E Valente, Teresa C Riga, Ashton P Frulla, Ruth Masterson Creber, William Whang, Hasan Garan, Haomiao Jia, Robert R Sciacca, Daniel Y Wang
BACKGROUND: Atrial fibrillation is a major public health problem and is the most common cardiac arrhythmia, affecting an estimated 2.7 million Americans. The true prevalence of atrial fibrillation is likely underestimated because episodes are often sporadic; therefore, it is challenging to detect and record an occurrence in a "real world" setting. To date, mobile health tools that promote earlier detection and treatment of atrial fibrillation and improvement in self-management behaviors and knowledge have not been evaluated...
2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27316915/french-intensive-care-society-international-congress-r%C3%A3-animation-2016
#11
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27236108/effects-of-intensive-glucose-lowering-in-treatment-of-type-2-diabetes-mellitus-on-cardiovascular-outcomes-a-meta-analysis-of-data-from-58-160-patients-in-13-randomized-controlled-trials
#12
Hong-Juan Fang, Yu-Hao Zhou, Yong-Ji Tian, Han-Yang Du, Yan-Xia Sun, Li-Yong Zhong
BACKGROUND: Previous trials indicated that intensive glucose lowering in treatment of patients with type 2 diabetes mellitus (T2DM) was associated with a higher incidence of mortality. We therefore conducted a meta-analysis to evaluate the benefits and harms of intensive glucose lowering therapy in treatment of T2DM patients on major cardiovascular outcomes. METHODS: Randomized controlled trials (RCTs) were obtained from searches of PubMed, EmBase, and the Cochrane Library electronic databases until Feb...
September 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27063427/-cardiovascular-safety-of-incretin-based-antidiabetic-treatment-results-of-completed-clinical-trials
#13
REVIEW
György Jermendy
Several randomized, controlled clinical trials were initiated some years ago in order to evaluate the cardiovascular safety of the new antidiabetic drugs in patients with type 2 diabetes due to requirements from regulatory bodies. Four trials with incretin-based drugs (saxagliptin, alogliptin, sitagliptin and lixisenatide) have been completed so far. Based on the primary outcome endpoints of these trials no cardiovascular risks were found with incretins in patients with type 2 diabetes. As for saxagliptin, the hospitalization for heart failure was investigated as a secondary endpoint, and an increased risk was observed in the respective trial; however, this observation was widely debated later in the literature...
April 17, 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27049034/the-2015-dutch-food-based-dietary-guidelines
#14
REVIEW
D Kromhout, C J K Spaaij, J de Goede, R M Weggemans
The objective of this study was to derive food-based dietary guidelines for the Dutch population. The dietary guidelines are based on 29 systematic reviews of English language meta-analyses in PubMed summarizing randomized controlled trials and prospective cohort studies on nutrients, foods and food patterns and the risk of 10 major chronic diseases: coronary heart disease, stroke, heart failure, diabetes, breast cancer, colorectal cancer, lung cancer, chronic obstructive pulmonary disease, dementia and depression...
August 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/26889916/cardiac-troponin-in-patients-hospitalized-with-acute-decompensated-heart-failure-a-systematic-review-and-meta-analysis
#15
REVIEW
Mohammed Yousufuddin, Ahmed D Abdalrhim, Zhen Wang, M Hassan Murad
BACKGROUND: Elevated cardiac troponin (cTn) is often observed in patients with acute decompensated heart failure (ADHF). We assessed the magnitude of association and quality of supporting evidence between cTn and clinically important outcomes in persons hospitalized for ADHF. METHODS: We searched MEDLINE In-Process & Other Non-Indexed Citations, MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus from inception through February 28, 2015...
June 2016: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/25897628/red-blood-cell-transfusion-for-people-undergoing-hip-fracture-surgery
#16
REVIEW
Susan J Brunskill, Sarah L Millette, Ali Shokoohi, E C Pulford, Carolyn Doree, Michael F Murphy, Simon Stanworth
BACKGROUND: The incidence of hip fracture is increasing and it is more common with increasing age. Surgery is used for almost all hip fractures. Blood loss occurs as a consequence of both the fracture and the surgery and thus red blood cell transfusion is frequently used. However, red blood cell transfusion is not without risks. Therefore, it is important to identify the evidence for the effective and safe use of red blood cell transfusion in people with hip fracture. OBJECTIVES: To assess the effects (benefits and harms) of red blood cell transfusion in people undergoing surgery for hip fracture...
2015: Cochrane Database of Systematic Reviews
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