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https://www.readbyqxmd.com/read/28944709/the-cardiometabolic-effect-of-current-management-of-polycystic-ovary-syndrome-strategies-of-prevention-and-treatment
#1
Dinka Pavicic Baldani, Lana Skrgatic, Roya Ougouag, Miro Kasum
Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder amongst women of reproductive age, which is characterized by reproductive and cardiometabolic disturbances with long-term health repercussions. Insulin resistance (IR), impaired glucose tolerance, type 2 diabetes mellitus (DM2), obesity and dyslipidemia occur more in women with PCOS than in age-comparable women without PCOS. Long term data regarding risks or benefits of medical intervention for metabolic dysfunction of PCOS are lacking. Therapies, such as oral contraceptives (OCPs) and anti-androgenic medications used to manage the reproductive manifestations of PCOS, may themselves be the cause of cardiometabolic perturbations...
September 23, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28944702/relationship-between-serum-anti-mullerian-hormone-and-intrafollicular-amh-levels-in-pcos-women
#2
M Stracquadanio, L Ciotta, M A Palumbo
Polycystic ovary syndrome is a complex disease characterized by various endocrine disorders that are the potential cause of anovulation and hyperandrogenism. Anti-Müllerian hormone expression is suspected to be overexpressed in PCOS granulosa cells. AMH acts as a regulator of folliculogenesis: it is produced by the granulosa cells of follicles from the stage of the primary follicle to the initial formation of the antrum. Serum and intrafollicular AMH levels are elevated in patients with PCOS due to increased number of small follicles and an increased secretion within each of these small follicles...
September 23, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28944495/functional-morphology-of-the-gonoduct-of-the-viviparous-teleost-poeciliopsis-gracilis-heckel-1848-poeciliidae
#3
Juan Carlos Campuzano-Caballero, Mari Carmen Uribe
Female teleosts do not develop Müllerian ducts; consequently, the ovary of teleosts contains two zones: germinal and gonoduct. The gonoduct lacks germinal cells, but has relevant functions in the reproductive process. We describe the functional morphology of the gonoduct in the viviparous teleost Poeciliopsis gracilis during nongestation and gestation stages. This study tests the hypothesis that the gonoduct functions as a barrier between the germinal zone and the exterior. By providing information about morphology and function of the gonoduct we show that this part of the ovary has an essential role in the reproduction of teleosts...
September 25, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28943940/leptomeningeal-metastasis-of-pulmonary-large-cell-neuroendocrine-carcinoma-a-case-report-and-review-of-the-literature
#4
Guozi Yang, Zhenyu Pan, Ning Ma, Limei Qu, Tingting Yuan, Xiaochuan Pang, Xu Yang, Lihua Dong, Shixin Liu
Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a rare and malignant form of lung cancer with a poor prognosis for patients. The common sites of metastases are the liver, adrenal glands, bone and brain. LCNEC rarely metastasizes to the small intestine, ovaries, tonsils, mandible, vulva or spine. To the best of our knowledge, there have been no reports of leptomeningeal metastasis of LCNEC to date. The present case report describes an unusual case of leptomeningeal metastasis from pulmonary LCNEC alongside a review of the literature...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943446/evaluation-of-genotoxicity-and-subchronic-toxicity-of-the-standardized-leaves-infusion-extract-of-copaifera-malmei-harms-in-experimental-models
#5
Eduarda Pavan, Amilcar Sabino Damazo, Larissa Maria Scalon Lemos, Bulus Adzu, Sikiru Olaitan Balogun, Karuppusamy Arunachalam, Domingos Tabajara de Oliveira Martins
ETHNOPHARMACOLOGICAL RELEVANCE: Copaifera malmei Harms (Fabaceae), known mainly as óleo-mirim, is a native and endemic plant found in the states of Mato Grosso and Goiás of Brazil. The plant's leaves infusion is popularly used by riverine communities of the northern Araguaia microregion, Mato Grosso, Brazil, for the treatment of gastric ulcers and inflammatory diseases of the respiratory tract. The gastric antiulcer activity of the standardized leaves infusion extract of Copaifera malmei (SIECm) in rodents has been reported...
September 21, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28943050/small-cell-carcinoma-of-the-ovary-hypercalcemic-type-clinical-and-imaging-review
#6
REVIEW
Brinda Rao Korivi, Sanaz Javadi, Silvana Faria, Tara Sagebiel, Naveen Garg, Madhavi Patnana, Srinivasa R Prasad
Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT) is a rare, aggressive malignancy with a poor prognosis. Its features are difficult to differentiate from other ovarian malignancies. In this article, we discuss recent advances in our understanding of this rare malignancy including tumor genetics. We also describe demographic, clinical and imaging findings, staging, and treatment options.
September 1, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28942697/ovarian-masses-in-pediatric-patients-a-multicenter-study-of-98-surgical-cases-in-tunisia
#7
I Abid, M Zouari, M Jallouli, S Sahli, A Bouden, R Ben Abdallah, F Trabelsi, A Jabloun, A Charieg, C Mrad, M Marzouki, S Mosbahi, A Ezzi, R Mootamri, M Hamzaoui, N Kaabar, S Jlidi, A Nouri, R Mhiri
Ovarian masses requiring surgical intervention are uncommon in the pediatric population. Our aim is to report results of a multicentric Tunisian study concerning the clinical practice and the management of pediatric ovarian masses and to identify the factors that are associated with ovarian preservation. Between January 2000 and December 2015, 98 pediatric patients (<14 years) were surgically treated for ovarian masses at the five pediatric surgery departments in Tunisia. Ninety-eight patients were included in this study...
September 23, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28942695/ovarian-stimulation-under-the-effect-of-isotretinoin
#8
Mauro Cozzolino, Javier Domingo, Sérgio Reis Soares
Isotretinoin (13-cis-retinoic acid) is a pharmaceutical vitamin A analog that is frequently used in the treatment of severe cystic acne, many women at reproductive age being exposed to this substance. This drug has a clearly documented teratogenicity and data from rodents and humans indicate that a direct aggression to ovarian follicles also occurs. Here we report the case of a 29-year-old woman with breast cancer referred for emergency preservation of reproductive potential that used isotretinoin up to the day before the initiation of ovarian stimulation...
September 23, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28942579/distribution-of-tomato-planta-macho-viroid-in-germinating-pollen-and-transmitting-tract
#9
Yosuke Matsushita, Hironobu Yanagisawa
Vertical and horizontal pollen transmission is important for efficient infection by viroids. Vertical pollen transmission of viroids is attributed to the infection by viroid in the embryo sac through infected pollen. To identify the viroid infection in pollen and pollen tubes elongating through the transmitting tract, we used in situ hybridization to histochemically analyze the distribution of Tomato planta macho viroid (TPMVd) in pollen grains, the stigma, and style of petunia plants. TPMVd was present in the generative nucleus and vegetative nucleus of mature infected pollen grains and germinating pollen grains...
September 23, 2017: Virus Genes
https://www.readbyqxmd.com/read/28942551/androgen-excess-and-metabolic-disorders-in-women-with-pcos-beyond-the-body-mass-index
#10
REVIEW
R A Condorelli, A E Calogero, M Di Mauro, L M Mongioi', R Cannarella, G Rosta, S La Vignera
BACKGROUND: Insulin resistance is a common feature among women with polycystic ovary syndrome (PCOS), especially in those patients with hyperandrogenism and chronic anovulation. PCOS women are at risk for developing metabolic syndrome, impaired glucose tolerance and type II diabetes mellitus (DM II). OBJECTIVE: The aim of this review is to explore the existing knowledge of the interplay between androgen excess, pancreatic β-cell function, non-alcoholic fatty liver disease (NAFLD), intra-abdominal and subcutaneous (SC) abdominal adipocytes in PCOS, providing a better comprehension of the molecular mechanisms of diabetologic interest...
September 23, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28942426/rapid-dna-synthesis-during-early-drosophila%C3%A2-embryogenesis-is-sensitive-to-maternal-humpty-dumpty-protein-function
#11
Shera Lesly, Jennifer L Bandura, Brian R Calvi
Problems with DNA replication cause cancer and developmental malformations. It is not fully understood how DNA replication is coordinated with development and perturbed in disease. We had previously identified the Drosophila gene humpty dumpty (hd) and showed that null alleles cause incomplete DNA replication, tissue undergrowth, and lethality. Animals homozygous for the missense allele, hd(272-9) , were viable, but adult females had impaired amplification of eggshell protein genes in the ovary, resulting in the maternal effects of thin eggshells and embryonic lethality...
September 23, 2017: Genetics
https://www.readbyqxmd.com/read/28942372/restoration-of-fresh-cat-ovarian-tissue-function-by-autografting-to-subcutaneous-tissue-a-pilot-study
#12
Ellen C R Leonel, Janice M V Vilela, Raísa E G Paiva, José L P R Jivago, Rodrigo S Amaral, Carolina M Lucci
Ovarian tissue transplantation could be a valuable technique for the preservation of endangered animals. The domestic cat affords an adequate experimental model for studies aimed at wild felids due to its phylogenetic similarity. Thus, this pilot study evaluated the efficacy of cat ovarian tissue autotransplantation to a peripheral site. Three adult queens were submitted to ovariohysterectomy. The ovaries were fragmented into eight pieces; two were fixed as a control and six were transplanted to subcutaneous tissue of the dorsal neck...
September 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28942305/role-of-components-of-the-insulin-like-growth-factor-system-in-the-early-stages-of-ovarian-follicular-persistence-in-cattle
#13
F M Rodríguez, N C Gareis, G J Hein, N R Salvetti, A N Amweg, E Huber, A F Stassi, H H Ortega, F Rey
Cystic ovarian disease (COD) is one of the main causes of infertility in dairy cattle. It has been postulated that the insulin-like growth factor (IGF) system may contribute to follicular persistence and development of COD. The initiation of the IGF response is a result of interactions between IGF-binding proteins (IGFBPs) and IGFBP proteases, mainly pregnancy-associated plasma protein A (PAPP-A). IGFBPs bind IGFs with high affinity and consequently regulate their access to IGF receptors (IGFRs). The aim of this research was to determine variations in components of the IGF system in the ovaries of cows with persistent follicles induced by long-term administration of progesterone...
August 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28942303/lymphoma-koala-retrovirus-infection-and-reproductive-chlamydiosis-in-a-koala-phascolarctos-cinereus
#14
J Fabijan, L Woolford, S Lathe, G Simmons, F Hemmatzadeh, D J Trott, N Speight
Koala retrovirus (KoRV) infection, thought to be associated with lymphoid neoplasia, and Chlamydia pecorum-related ocular and urogenital disease are both highly prevalent in eastern Australian koala (Phascolarctos cinereus) populations. However, in South Australian koalas, little is known about KoRV infection and C. pecorum-associated disease. We report the first South Australian case of lymphoma in a KoRV-A-positive female koala also affected by severe reproductive chlamydiosis. The koala was from the Mount Lofty Ranges population and was presented with hindlimb lameness...
August 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28942151/molecular-characterization-of-mitochondrial-zucchini-and-its-relation-to-nuage-pirna-pathway-components-in-bombyx-mori-ovary-derived-bmn4-cells
#15
Anandrao Ashok Patil, Tsuneyuki Tatsuke, Hiroaki Mon, Jae Man Lee, Daisuke Morokuma, Masato Hino, Takahiro Kusakabe
Piwi-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with PIWI subfamily proteins, which play an important role in transposon silencing in animal germ cell. The piRNAs biogenesis is divided into two major pathways: primary and secondary, and both pathways are independent of double-stranded RNA-processing enzyme Dicer, which processes the single-stranded RNA transcripts in microRNA (miRNA) and siRNA (small interfering RNA) pathway. Primary piRNAs are processed from long non-coding RNA precursors transcribed from piRNA clusters...
September 20, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28942052/phylogenetic-relationships-of-hemiuridae-digenea-hemiuroidea-with-new-morphometric-and-molecular-data-of-aphanurus-mugilis-tang-1981-aphanurinae-from-mullet-fish-of-vietnam
#16
D M Atopkin, V V Besprozvannykh, A Yu Beloded, H D Ngo, N V Ha, N V Tang
Adult Aphanurus mugilis Tang, 1981 worms were detected in the intestine of Moolgarda engeli in the shallow waters off Cat Ba Island, Vietnam. Tang (1981) first described this species in Mugil cephalus off China. The worms in Vietnamese mullet were identical to Chinese specimens in a number of morphometric characteristics, with the exception of body and ovary size. In the present study, morphological characteristics, and the first molecular data for A. mugilis are provided. Additionally, molecular phylogenetic analysis of the family Hemiuridae was performed...
September 20, 2017: Parasitology International
https://www.readbyqxmd.com/read/28941255/effects-of-placebo-controlled-insulin-sensitizing-drugs-on-hormonal-parameters-in-polycystic-ovary-syndrome-patients-a-network-meta-analysis
#17
Yong-Hui Dai, Rong Huang, Peng-Fei Zhao, Jian-Hua Xu, Dong-Dong Liu, Fu-Dong Luo
This network meta-analysis was conducted to compare effects of different placebo-controlled insulin-sensitizing drugs, including metformin, pioglitazone, rosiglitazone and troglitazone on hormonal parameters in polycystic ovary syndrome (PCOS) patients. We searched PubMed, EMBASE and Cochrane Library databases from their inception to July 2017. Randomized controlled trials (RCTs) met our inclusion criteria were included. We combined direct and indirect evidences to evaluate weighted mean difference (WMD) value and draw surface under the cumulative ranking curve (SUCRA)...
September 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28941069/identification-and-functional-analysis-of-chitin-synthase-a-in-oriental-armyworm-mythimna-separata
#18
Yifan Zhai, Xiaobin Fan, Zhenjuan Yin, Xiangzhao Yue, Xingyuan Men, Li Zheng, Wenqing Zhang
Chitin synthases are very important enzymes for chitin synthesis in various species, which makes them a specific target of insecticides. In the present study, we investigated the function of the chitin synthase A (CHSA) gene isolated from Mythimna separata. The majority of dsMysCHSA treated larvae (89.50%) exhibited lethal phenotypes, including three phenotypes with severe cuticle deformations. The dsMysCHSA treatment in adult females affected oogenesis, and significantly reduced the ovary size and the oviposition number compared with controls...
September 22, 2017: Proteomics
https://www.readbyqxmd.com/read/28940857/prevalence-of-dermatologic-manifestations-and-metabolic-biomarkers-in-women-with-polycystic-ovary-syndrome-in-north-china
#19
Jin-Ge Feng, Yan Guo, Li-Ang Ma, Jin Xing, Rui-Feng Sun, Wei Zhu
BACKGROUND: Cutaneous features of hyperandrogenism in polycystic ovary syndrome (PCOS) include acne, hirsutism, seborrhea, androgenic alopecia (AGA), and acanthosis nigricans (AN). However, the relationships have not been well known broadly in terms of clinical hyperandrogenism and biochemical markers. OBJECTIVES: The aim of this study was to investigate biochemical and metabolic parameters in relation to cutaneous characters women in with and without PCOS. METHODS: This was a cross-sectional retrospective study including 186 women with PCOS and 113 age-matched without PCOS women...
September 21, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28940132/formation-of-multiple-oocyte-follicles-in-culture
#20
Alice P Christensen, Emeline Peyrache, Heidy Kaune, Suzannah A Williams
Basement membranes are found in every organ of the body. They provide structure and a selective filter for molecules. The ovary is no different with the follicular basal lamina (FBL) separating the granulosa and theca cells, facilitating regulation of the changing follicular environment providing appropriate conditions for the developing oocyte. The FBL is modified in C1galt1 Mutant mice (C1galt1 (FF):ZP3Cre) resulting from oocyte-specific deletion of C1galt1. Changes in the FBL lead to follicles joining to generate multiple-oocyte follicles (MOFs); where two or more oocytes are contained within a single follicle...
September 22, 2017: In Vitro Cellular & Developmental Biology. Animal
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