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T h Somers, V Houben, G Goovaerts, P J Govaerts, F E Offeciers
A histological study was performed on total human tympanic membranes with a central perforation. The specimens originated from 30 consecutive and unselected operations in which a total myringectomy was performed prior to reconstruction by means of a tympanic allograft. Beside excessive thickening of the tympanic membrane in 73%, all membranes showed other histological abnormalities: inflammation (97%), excessive fibrosis (97%), tympanosclerosis (80%), hyperkeratosis (83%), rete riges (43%) and epithelial inclusions (6%)...
April 1997: Clinical Otolaryngology and Allied Sciences
M D DiLeo, R G Amedee
Investigators have attempted to simplify and improve myringoplasty. However, techniques have not been applied to large, chronic human tympanic membrane perforations. Fibrin glue has been shown to improve wound strength but has not been significantly utilized in myringoplasty. To evaluate the effectiveness of paper patch myringoplasty reinforced with fibrin glue, 15 guinea pigs underwent repeated myringectomy to form persistent (>50%) perforations. The right ears were repaired with a paper patch and fibrin glue (treatment group), and the left ears with a paper patch alone (control group)...
January 1996: ORL; Journal for Oto-rhino-laryngology and its related Specialties
E Truy, F Disant, A Morgon
Acute perforations in the tympanic membranes (TM) of animals are not good models for assessment of materials used as graft membranes or of substances with the potential to activate tympanic membrane healing mechanisms for closing perforations. Most acute TM perforations heal spontaneously, in both animals and humans. Acute TM perforation models are not analogous to the pathologic human problem of long-standing TM perforation. Bilateral subtotal symmetric perforations, with each animal serving as its own control provide a suitable model...
March 1995: American Journal of Otology
R Sugita, S Kawamura, G Ichikawa, Y Fujimaki, K Deguchi
Middle ear effusions from 574 patients with acute otitis media (AOM) were sampled and cultured in metropolitan Tokyo. Sampling was done by myringectomy and from otorrhea after the occurrence of spontaneous perforation. Streptococcus pneumoniae and Haemophilus influenzae were isolated more widely in 'fresh' (myringotomized) cases than in 'old' cases. The freshness of cases, and the sampling and culture techniques appear to account for the difference in reports concerning causative pathogens of AOM from Japan on one hand and the U...
November 1983: International Journal of Pediatric Otorhinolaryngology
J D Osguthorpe
The efficacy of tympanometry in the diagnosis of ossicular abnormalities and the differentiation of such from eardrum scarring is controversial. This paper presents a study of the tympanometric effects of specific eardrum scars and ossicular abnormalities in cats. For both normal eardrums and healed myringotomies, a normal middle ear could be differentiated from stapes fixation or incudostapedial discontinuity using static immittance parameters and tympanogram morphology. Twenty percent myringectomy scars caused abnormal 660 Hz tympanograms but this effect could be distinguished from changes caused by a concomitant ossicular abnormality...
December 1986: Laryngoscope
C P Amoils, R K Jackler, H Milczuk, K E Kelly, K Cao
Previous investigations into the healing and reconstruction of tympanic membrane (TM) perforations have involved animal models with acute TM perforations. A problem with the acute TM perforation model is that most acute TM perforations will heal spontaneously, both in animals and human beings. A second inadequacy of acute perforation models is that they are not analogous to the salient problem in human beings: long-standing TM perforation. The ideal animal model must have a TM perforation that is permanent, well-epithelialized, and free from infection...
January 1992: Otolaryngology—Head and Neck Surgery
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