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Thomas Zahnert, Marie-Luise Metasch, Hannes Seidler, Matthias Bornitz, Nicoloz Lasurashvili, Marcus Neudert
HYPOTHESIS: Electromagnetical excitation of ossicular vibration is suitable for middle ear transmission measurements in the experimental and clinical setting. Thereby, it can be used as a real-time monitoring system for quality control in ossiculoplasty. BACKGROUND: Positioning and coupling of middle ear prosthesis are a precondition for good postoperative hearing results, but at the same time completely dependent upon the surgeon's subjective judgment during surgery...
October 4, 2016: Otology & Neurotology
Gardiner von Trapp, Ishita Aloni, Stephen Young, Malcolm N Semple, Dan H Sanes
The consequences of developmental hearing loss have been reported to include both sensory and cognitive deficits. To investigate these issues in a non-human model, auditory learning and asymptotic psychometric performance were compared between normal hearing (NH) adult gerbils and those reared with conductive hearing loss (CHL). At postnatal day 10, before ear canal opening, gerbil pups underwent bilateral malleus removal to induce a permanent CHL. Both CHL and control animals were trained to approach a water spout upon presentation of a target (Go stimuli), and withhold for foils (Nogo stimuli)...
October 13, 2016: Hearing Research
Ahmed Omran, Fatthi Abdel Baki, Ahmed Amin
OBJECTIVE: To assess the effectiveness of glass ionomer bone cement (GIBC) in lateral attic wall reconstruction after primary acquired attic cholesteatoma surgery. MATERIALS AND METHODS: This prospective study was conducted on twenty children collected from the ENT outpatient clinics of a secondary and tertiary hospital. All patients presented with chronic suppurative otitis media with cholesteatoma of the primary acquired attic type. All patients underwent intact canal wall mastoidectomy (ICWM) with a transcanal atticotomy to address primary cholesteatoma involving the attic and the supratubal recess...
August 2016: Journal of International Advanced Otology
Jose Francisco Rodríguez-Vázquez, Yohei Honkura, Yukio Katori, Gen Murakami, Hiroshi Abe
The existence of hard tissue pulleys that act to change the direction of a muscle insertion tendon is well known in the human body. These include (1) the trochlea for the extraocular obliquus superior muscle, (2) the pterygoid hamulus for the tensor veli palatini muscle, (3) the deep sulcus on the plantar aspect of the cuboid bone for the peroneus longus tendon, (4) the lesser sciatic notch for the obturator internus muscle, and (5) the bony trochleariformis process for the tensor tympani muscle tendon. In addition, (6) the stapedius muscle tendon shows a lesser or greater angulation at the pyramidal eminence of the temporal bone...
September 29, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
Alexander Stoessel, Romain David, Philipp Gunz, Tobias Schmidt, Fred Spoor, Jean-Jacques Hublin
The diminutive middle ear ossicles (malleus, incus, stapes) housed in the tympanic cavity of the temporal bone play an important role in audition. The few known ossicles of Neandertals are distinctly different from those of anatomically modern humans (AMHs), despite the close relationship between both human species. Although not mutually exclusive, these differences may affect hearing capacity or could reflect covariation with the surrounding temporal bone. Until now, detailed comparisons were hampered by the small sample of Neandertal ossicles and the unavailability of methods combining analyses of ossicles with surrounding structures...
October 11, 2016: Proceedings of the National Academy of Sciences of the United States of America
Hong Chan Kim, Chul Ho Jang, Chung Man Sung, Eun Kyung Jung, Yong Beom Cho
No abstract text is available yet for this article.
September 12, 2016: Brazilian Journal of Otorhinolaryngology
Marcus Neudert, Matthias Bornitz, Nikoloz Lasurashvili, Uwe Schmidt, Thomas Beleites, Thomas Zahnert
HYPOTHESIS: Prosthesis' length creates tension in ossicular reconstructions, which directly effects the middle ear sound transmission. BACKGROUND: Relatively long prostheses are often used to stabilize the middle ear reconstruction to prevent dislocation. Thereby, tension on the flexible components such as the tympanic membrane (TM) and the annular ligament (AL) is increased. Only little is known on the amount of displacement-related stiffening of the TM and AL, as well as the consecutive reduction in middle ear transfer function (METF)...
October 2016: Otology & Neurotology
Elke Loos, Nicolas Verhaert, Annelore Willaert, Koenraad Devriendt, Ann Swillen, Robert Hermans, Katya Op de Beeck, Greet Hens
The 22q11 deletion syndrome (22q11DS), the most frequent microdeletion syndrome in humans, presents with a large variety of abnormalities. A common abnormality is hearing impairment. The exact pathophysiological explanation of the observed hearing loss remains largely unknown. The aim of this study was to analyze the middle and inner ear malformations as seen on computer tomographic imaging in patients with 22q11DS. We retrospectively reviewed the charts of 11 22q11DS patients who had undergone a CT of the temporal bone in the past...
November 2016: American Journal of Medical Genetics. Part A
Hamid R Djalilian, Hossein Mahboubi, Yarah M Haidar, Peyton Paulick, Mark W Merlo, Mark Bachman
OBJECTIVES/HYPOTHESIS: To develop a novel completely-in-the-canal device capable of directly driving the tympanic membrane (TM) and ossicular chain from the ear canal. STUDY DESIGN: Development and feasibility study. METHODS: A voice coil actuator design was developed to drive the TM. Bench testing of the device using laser Doppler vibrometry (LDV) and sound recording was performed. Temporal bone studies using LDV were performed using different designs of the contact tip-TM interface to find the most efficient method of sound transmission...
August 22, 2016: Laryngoscope
Erdal Sakalli, Cengiz Celikyurt, Sultan Biskin, Selcuk Cem Erdurak
We describe a novel myringoplasty procedure. We placed a separated fascia graft descending from the scutum, combined with underlay myringoplasty, to support an anterosuperior perforation. We reviewed data from patients who underwent myringoplasty procedures to treat perforations extending into the anterosuperior quadrant of the pars tensa from October 2012 to June 2014. A total of 42 patients who were followed for a minimum of 1 year were enrolled. The same technique was used in all operations. The tympanomeatal flap was elevated from the neck of malleus up to the tip of the lateral process of malleus...
August 11, 2016: European Archives of Oto-rhino-laryngology
Maimi Ozeki-Satoh, Aoi Ishikawa, Shigehito Yamada, Chigako Uwabe, Tetsuya Takakuwa
We describe the three-dimensional morphogenesis of the middle ear ossicles (MEOs) according to Carnegie stage (CS) in human embryos. Seventeen samples including 33 MEOs from CS18 to 23 were selected from the Kyoto Collection. The primordia of the MEOs and related structures were histologically observed and three-dimensionally reconstructed from digital images. The timing of chondrogenesis was variable among structures. The stapes was recognizable as a vague condensation of the mesenchymal cells in all samples from CS18, whereas the malleus and incus were recognizable at CS19...
October 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
Gabrielle R Merchant, Saumil N Merchant, John J Rosowski, Hideko Heidi Nakajima
Current clinical practice cannot distinguish, with any degree of certainty, the multiple pathologies that produce conductive hearing loss in patients with an intact tympanic membrane and a well-aerated middle ear without exploratory surgery. The lack of an effective non-surgical diagnostic procedure leads to unnecessary surgery and limits the accuracy of information available during pre-surgical consultations with the patient. A non-invasive measurement to determine the pathology responsible for a conductive hearing loss prior to surgery would be of great value...
August 3, 2016: Hearing Research
Charlotte M Burford, Matthew J Mason
It is widely accepted by developmental biologists that the malleus and incus of the mammalian middle ear are first pharyngeal arch derivatives, a contention based originally on classical embryology that has now been backed up by molecular evidence from rodent models. However, it has been claimed in several studies of human ossicular development that the manubrium of the malleus and long process of the incus are actually derived from the second arch. This 'dual-arch' interpretation is commonly presented in otolaryngology textbooks, and it has been used by clinicians to explain the aetiology of certain congenital abnormalities of the human middle ear...
July 26, 2016: Journal of Anatomy
Adedoyin Kalejaiye, Neelam Giri, Carmen C Brewer, Christopher K Zalewski, Kelly A King, Charleen D Adams, Philip S Rosenberg, H Jeffrey Kim, Blanche P Alter
BACKGROUND: The inherited bone marrow failure syndromes (IBMFSs) are diverse disorders with syndrome-specific features; their otologic and audiologic manifestations have not been well described. Our objective was to characterize these in patients with Fanconi anemia (FA), dyskeratosis congenita (DC), Diamond-Blackfan anemia (DBA), and Shwachman-Diamond syndrome (SDS), and to determine the association between physical findings and hearing loss. METHODS: Patients with an IBMFS underwent comprehensive clinical and laboratory evaluations and testing for syndrome-specific gene mutations...
July 18, 2016: Pediatric Blood & Cancer
M Stapper, T Stange
Isolated fracture of the handle of the malleus is a rare cause of conductive hearing loss and represents a challenge for the otolaryngologist in terms of past medical history, diagnostics, and therapy.
June 6, 2016: HNO
Taher Valika, Miriam Redleaf
OBJECTIVES: This retrospective chart review demonstrates that the prevalence of middle cranial fossa (MCF) dehiscence on computed tomography (CT) scans increases with age. METHODS: High-resolution temporal bone CT scans, which had been obtained for any otologic complaint, were reviewed independent of all clinical history. Scans showing soft tissue, fluid, trauma, or previous operations were excluded. The CTs from 183 patients (296 ears) were reviewed, blinded for age and body mass index (BMI)...
September 2016: Annals of Otology, Rhinology, and Laryngology
Richard P Tucker, Cathryn A Peterson, Ismail Hendaoui, Sandrine Bichet, Ruth Chiquet-Ehrismann
The ossicles of the middle ear (the malleus, incus and stapes) transmit forces resulting from vibrations of the tympanic membrane to the cochlea where they are coded as sound. Hearing loss can result from diseases such as rheumatoid arthritis (RA) that affect the joints between the ossicles or degenerative processes like otosclerosis that lead to ankylosis of the footplate of the stapes in the oval window of the cochlea. In this study, immunohistochemistry was used to determine if the extracellular matrix glycoproteins tenascin-C or tenascin-W are expressed in the incudomalleolar and incudostapedial joints of ossicles dissected from human cadavers...
September 2016: Journal of Anatomy
Luis A Vallejo, María T Manzano, Antonio Hidalgo, Alberto Hernández, Juan Sabas, Hugo Lara, Elisa Gil-Carcedo, David Herrero
INTRODUCTION AND OBJECTIVES: One of the problems with total ossicular replacement prostheses is their stability. Prosthesis dislocations and extrusions are common in middle ear surgery. This is due to variations in endo-tympanic pressure as well as design defects. The design of this new prosthesis reduces this problem by being joined directly to the malleus handle. The aim of this study is to confirm adequate acoustic-mechanical behaviour in fresh cadaver middle ear of a new total ossicular replacement prosthesis, designed using the finite elements method...
May 17, 2016: Acta Otorrinolaringológica Española
Volkan Gungor, Gamze Atay, M Demir Bajin, Mehmet Yarali, Sarp Sarac, Levent Sennaroglu
OBJECTIVE: In this study, functional results of different bone cement ossiculoplasty techniques are compared. METHODS: Retrospective case review at a tertiary referral center. Patients who underwent middle ear surgery and bone cement ossiculoplasty between 2006-2012 were included. A total of 52 patients, including 30 patients with 'Incus to stapes' (Group 1) and 13 patients with 'malleus to stapes' (Group 2), five patients with 'incudoplasty + stapedotomy' (Group 3), and four patients with 'malleus to incus' (Group 4) ossiculoplasty were enrolled in the study...
September 2016: Acta Oto-laryngologica
Bassem Ashraf, Mohamed Rashad Ghonim, Hesham Mohamad Eladl, Hossam Elsisi
The goals of cholesteatoma surgery are complete eradication of the disease and if possible restoration of hearing of the patient. A technique that allows a surgeon to achieve these goals. The advantages of the intact canal technique are rapid healing and being more functional. But cholesteatoma recidivism is common after this technique. The introduction of malleus relocation technique favors the use of the repositioned malleus in ossiculoplasty with more stable ossiculoplasty and better hearing outcomes. But no study has presented its role in ICW surgery for cholesteatoma...
April 18, 2016: Clinical Otolaryngology
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