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Roux en Y Gastric Bypass

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https://www.readbyqxmd.com/read/29330917/mitochondrial-respiratory-capacity-remains-stable-despite-a-comprehensive-and-sustained-increase-in-insulin-sensitivity-in-obese-patients-undergoing-gastric-bypass-surgery
#1
Michael T Lund, Steen Larsen, Merethe Hansen, Julie Courraud, Andrea K Floyd, Mikael Støckel, Jørn W Helge, Flemming Dela
AIM: It has been proposed, but not yet demonstrated by convincing evidence in published articles, that insulin resistance and mitochondrial respiratory function are causally-related physiological phenomena. Here, we tested the prediction that weight loss induced increase in insulin sensitivity will correlate with a corresponding change in mitochondrial respiratory capacity over the same time period. METHODS: Insulin sensitivity was evaluated using the hyperinsulinaemic-euglycemic clamp technique and skeletal muscle mitochondrial respiratory capacity was evaluated by high-resolution respirometry in 26 patients with obesity...
January 13, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29327183/bidirectional-jejunojejunal-anastomosis-prevents-early-small-bowel-obstruction-due-to-the-kinking-after-closure-of-the-mesenteric-defect-in-the-laparoscopic-roux-en-y-gastric-bypass
#2
Pierre Munier, Hefzi Alratrout, Iole Siciliano, Philippe Keller
BACKGROUND: The closure of the mesenteric defects (CMD) in Roux-en-Y gastric bypass (RYGB) reduces the risk of small bowel obstruction (SBO) due to internal hernia but might be associated with an increased risk of early SBO triggered by the jejunojejunal anastomosis (JJS) kinking. The aim of this study was to assess how enlarging the JJS with a bidirectional linear stapling can aid in avoiding the risk of early SBO by kinking. MATERIALS AND METHODS: This retrospective cohort study concerns 1327 patients who underwent RYGB with CMD between May 2007 and August 2016...
January 11, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29327182/changes-in-iron-absorption-after-roux-en-y-gastric-bypass
#3
Wendy Schijns, Marjolein A P Ligthart, Frits J Berends, Ignace M C Janssen, Cees J H M van Laarhoven, Edo O Aarts, Hans de Boer
INTRODUCTION: Iron deficiency is one of the most common deficiencies that may occur after Roux-en-Y gastric bypass (RYGB). Little is known about the optimal treatment of post-RYGB iron deficiency. AIM: The aim of this study is to evaluate the changes in iron absorption characteristics after RYGB for two oral iron formulations, one presented in tablet form and one as in the form of a solution. METHOD: Iron absorption in 24 obese women was studied before and 1 month after RYGB...
January 11, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29318504/oral-vitamin-b12-supplementation-after-roux-en-y-gastric-bypass-a-systematic-review
#4
Kamal K Mahawar, Alastair Reid, Yitka Graham, Lindes Callejas-Diaz, Chetan Parmar, William Rj Carr, Neil Jennings, Rishi Singhal, Peter K Small
BACKGROUND: Many respectable guidelines recommend lifelong vitamin B12 injections for Roux-en-Y gastric bypass (RYGB) patients in the absence of lack of consensus on the efficacy of oral route of prophylaxis and the appropriate doses needed for this purpose. The purpose of this review was to examine the published English language scientific literature in accordance with PRISMA principles to find out if orally given vitamin B12 is adequate for prophylactic purposes in RYGB patients and the appropriate dosages needed for this purpose if it is...
January 9, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29318008/novel-technique-using-a-bioabsorbable-prosthesis-with-fibrin-glue-fixation-to-prevent-a-petersen-s-space-hernia
#5
Mark Magdy, Hyerim Suh, Vytauras Kuzinkovas
Laparoscopic Roux-en-Y gastric bypass is a bariatric operation that is effective for long-term weight loss. Although rare, one serious complication is an internal hernia through Petersen's space, which may result in bowel strangulation. Although the incidence of internal hernia can be reduced through closing the Petersen's defect, it does not eliminate the risk. This case describes a novel and reliable method to close Petersen's defect. We report the case of a 30-year-old female who underwent a laparoscopic Roux-en-Y gastric bypass for the management of morbid obesity...
December 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29313123/15-year-experience-of-laparoscopic-single-anastomosis-mini-gastric-bypass-comparison-with-other-bariatric-procedures
#6
Nawaf Alkhalifah, Wei-Jei Lee, Tan Chun Hai, Kong-Han Ser, Jung-Chien Chen, Chun-Chi Wu
BACKGROUND: Laparoscopic single anastomosis (mini-)gastric bypass (LSAGB) has been validated as a safe and effective treatment for morbid obesity. However, data of the long-term outcome remain lacking. METHODS: Between October 2001 and December 2015, 1731 morbidly obese patients who received LSAGB as primary bariatric procedure at the Min-Sheng General Hospital were recruited. Surgical outcome, weight loss, resolution of comorbidities, and late complications were followed, then compared with groups of laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (LSG)...
January 8, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29311357/cardiovascular-risk-factors-after-adolescent-bariatric-surgery
#7
Marc P Michalsky, Thomas H Inge, Todd M Jenkins, Changchun Xie, Anita Courcoulas, Michael Helmrath, Mary L Brandt, Carroll M Harmon, Mike Chen, John B Dixon, Elaine M Urbina
BACKGROUND AND OBJECTIVES: Severely obese adolescents harbor numerous cardiovascular disease risk factors (CVD-RFs), which improve after metabolic and bariatric surgery (MBS). However, predictors of change in CVD-RFs among adolescents have not yet been reported. METHODS: The Teen-Longitudinal Assessment of Bariatric Surgery study (NCT00474318) prospectively collected anthropometric and health status data on 242 adolescents undergoing MBS at 5 centers. Predictors of change in CVD-RFs (blood pressure, lipids, glucose homeostasis, and inflammation) 3 years after Roux-en-Y gastric bypass and vertical sleeve gastrectomy were examined...
January 8, 2018: Pediatrics
https://www.readbyqxmd.com/read/29310367/should-roux-en-y-gastric-bypass-biliopancreatic-limb-length-be-tailored-to-achieve-improved-diabetes-outcomes
#8
Mário Nora, Tiago Morais, Rui Almeida, Marta Guimarães, Mariana P Monteiro
The objective is to access the role of Roux-en-Y gastric bypass (RYGB) biliopancreatic limb (BPL) length in type 2 diabetes (T2D) outcomes.RYGB is more effective than medical intervention for T2D treatment in obese patients. Despite the scarcity of available data, previous reports suggest that modifications of the RYGB limb lengths could improve the antidiabetic effects of the surgery.A cohort of obese T2D patients (n = 114) were submitted to laparoscopic RYGB, either with a standard BPL (SBPL) (n = 41; BPL 84 ± 2 cm) or long BPL (LBPL) (n = 73; BPL = 200 cm) and routinely monitored for weight loss and diabetic status up to 5 years after surgery...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29310339/an-unusual-case-of-perforation-of-the-alimentary-canal-following-bigu-a-taoist-fasting-technique
#9
Jun Wang, Jun Jin, Xiaofeng Xue, Yan Hao, Dongrong Li, Shan Xu, Fang Huang
RATIONALE: Bigu is a Taoist fasting technique interpreted as avoiding grains in the Encyclopedia of China. This technique has been used from ancient times to the present day in China and other parts of the world to achieve good health, weight loss, longevity, and even immortality. A variety of health problems have been identified in relation to the severe diet during Bigu. However, perforation of the alimentary canal has not been reported to be associated with Bigu. In the present study, we illustrated an unusual case of perforation of the alimentary canal in relation to Bigu...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29307107/upregulation-of-ghrelin-gene-expression-in-the-excluded-stomach-of-obese-women-with-type-2-diabetes-after-roux-en-y-gastric-bypass-in-the-surmetagit-study
#10
Danielle Cristina Fonseca, Priscila Sala, Joelle Singer, Pierre Singer, Raquel Susana Torrinhas, Dan Linetzky Waitzberg
BACKGROUND: Mechanisms of type 2 diabetes remission (T2Dr) after Roux-en-Y gastric bypass (RYGB) in obese patients appear to involve gastrointestinal hormones. OBJECTIVE: The objective of this study is to explore changes in ghrelin plasma levels and ghrelin gastrointestinal gene expression (GHRL) after RYGB, and their relationships to T2Dr. SETTING: In 20 obese women with T2D, before and 3 months after RYGB, we assessed GHRL expression by microarray and quantitative RT-PCR in gastrointestinal biopsy samples and plasma levels of ghrelin...
January 6, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29306650/common-weight-loss-procedures-and-their-complications
#11
REVIEW
Maria S Altieri, Brian Wright, Andrew Peredo, Aurora D Pryor
BACKGROUND: As the number of obese patients in the United States continues to grow, there is a parallel increase in the number of bariatric surgery patients. A quarter of these patients will return to the Emergency Department (ED) within the first two years of the index procedure. OBJECTIVE: An understanding of the most common bariatric procedures and their related complications will greatly aide the Emergency Medicine physician in the care of these patients. DISCUSSION: Abdominal pain is the most common reason for bariatric patients to present to the ED and can represent a diagnostic challenge to EM physicians...
December 2, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29306610/hypoglycemia-during-oral-glucose-tolerance-test-among-post-bariatric-surgery-pregnant-patients-incidence-and-perinatal-significance
#12
Amihai Rottenstreich, Ram Elazary, Yossef Ezra, Geffen Kleinstern, Nahum Beglaibter, Uriel Elchalal
BACKGROUND: While hypoglycemia during an oral glucose tolerance test (OGTT) has been shown to occur in a considerable portion of nonpregnant post-bariatric surgery (BS) patients, its incidence among pregnant post-BS patients evaluated for gestational diabetes has only been sparsely studied. OBJECTIVES: We investigated OGTT results and pregnancy outcomes in pregnant women who underwent 3 types of bariatric procedures before pregnancy. SETTING: A university hospital...
December 8, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29306011/adaptation-of-human-gut-microbiota-to-bariatric-surgeries-in-morbidly-obese-patients-a-systematic-review
#13
Hanieh-Sadat Ejtahed, Pooneh Angoorani, Shirin Hasani-Ranjbar, Seyed-Davar Siadat, Nasrin Ghasemi, Bagher Larijani, Ahmad-Reza Soroush
BACKGROUND: Bariatric surgeries have turned to be a popular therapeutic option for morbid obesity nowadays. Gut microbiota is supposed to be responsible as a part of the bariatric surgeries success. In this systematic review, we detailed the human studies which investigated the effect of different bariatric surgeries on the composition of gut microbiota. METHODS: We did a comprehensive search in PubMed, Web of Science, and Scopus for all clinical trials and longitudinal observational studies documented up to December 2015...
January 3, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29305304/sleeve-gastrectomy-surgery-when-2-alcoholic-drinks-are-converted-to-4
#14
María Belén Acevedo, J Christopher Eagon, Bruce D Bartholow, Samuel Klein, Kathleen K Bucholz, Marta Yanina Pepino
BACKGROUND: While it is well established that Roux-en-Y gastric bypass (RYGB) causes a rapid and heightened peak blood alcohol concentration (BAC), results from previous studies on the effects of sleeve gastrectomy (SG) on alcohol pharmacokinetics are conflicting. Data from 2 studies found SG did not affect BAC, whereas another study found SG caused a heightened peak BAC after alcohol ingestion. Moreover, these 3 studies estimated BAC from breathalyzers, which might not reliably estimate peak BAC...
November 10, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29302369/long-term-follow-up-for-type-2-diabetes-mellitus-after-gastrectomy-in-non-morbidly-obese-patients-with-gastric-cancer-the-legitimacy-of-onco-metabolic-surgery
#15
Tae-Hoon Lee, Chang Min Lee, Sungsoo Park, Do Hyun Jung, You Jin Jang, Jong-Han Kim, Seong-Heum Park, Young-Jae Mok
Purpose: This study primarily aimed to investigate the short- and long-term remission rates of type 2 diabetes (T2D) in patients who underwent surgical treatment for gastric cancer, especially patients who were non-obese, and secondarily to determine the potential factors associated with remission. Materials and Methods: We retrospectively reviewed the clinical records of patients with T2D who underwent radical gastrectomy for gastric cancer, from January 2008 to December 2012...
December 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29295558/effects-of-sleeve-gastrectomy-vs-roux-en-y-gastric-bypass-on-eating-behavior-and-sweet-taste-perception-in-subjects-with-obesity
#16
Katie Nance, J Christopher Eagon, Samuel Klein, Marta Yanina Pepino
The goal of this study was to test the hypothesis that weight loss induced by Roux-en-Y gastric bypass (RYGB) has greater effects on taste perception and eating behavior than comparable weight loss induced by sleeve gastrectomy (SG). We evaluated the following outcomes in 31 subjects both before and after ~20% weight loss induced by RYGB (n = 23) or SG (n = 8): (1) sweet, savory, and salty taste sensitivity; (2) the most preferred concentrations of sucrose and monosodium glutamate; (3) sweetness palatability, by using validated sensory testing techniques; and (4) eating behavior, by using the Food Craving Inventory and the Dutch Eating Behavior Questionnaire...
December 24, 2017: Nutrients
https://www.readbyqxmd.com/read/29290921/gut-brain-crosstalk-regulates-craving-for-fatty-food
#17
REVIEW
Rajendra Raghow
Patients undergoing Roux-en-Y gastric bypass (RYGB) surgery elicit striking loss of body weight. Anatomical re-structuring of the gastrointestinal (GI) tract, leading to reduced caloric intake and changes in food preference, are thought to be the primary drivers of weight loss in bariatric surgery patients. However, the mechanisms by which RYGB surgery causes a reduced preference for fatty foods remain elusive. In a recent report, Hankir et al described how RYGB surgery modulated lipid nutrient signals in the intestine of rats to blunt their craving for fatty food...
December 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/29290011/the-outcome-of-bariatric-surgery-in-patients-aged-75%C3%A2-years-and-older
#18
Zubaidah Nor Hanipah, Suriya Punchai, Linden A Karas, Samuel Szomstein, Rahul J Rosenthal, Stacy A Brethauer, Ali Aminian, Philip R Schauer
BACKGROUND: Bariatric surgery has been shown to be safe and effective in patients aged 60-75 years; however, outcomes in patients aged 75 or older are undocumented. METHODS: Patients aged 75 years and older who underwent bariatric procedures in two academic centers between 2006 and 2015 were studied. RESULTS: A total of 19 patients aged 75 years and above were identified. Eleven (58%) were male, the median age was 76 years old (range 75-81), and the median preoperative body mass index (BMI) was 41...
December 30, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29289697/guanylin-and-uroguanylin-mrna-expression-is-increased-following-roux-en-y-gastric-bypass-but-guanylins-do-not-play-a-significant-role-in-body-weight-regulation-and-glycemic-control
#19
María L Fernandez-Cachon, Søren L Pedersen, Kristoffer T Rigbolt, Chen Zhang, Katrine Fabricius, Henrik H Hansen, Lisbeth Elster, Lisbeth N Fink, Matthias Schäfer, Nicolai A Rhee, Ebbe Langholz, Erik Wandall, Steffen U Friis, Peter Vilmann, Viggo B Kristiansen, Christina Schmidt, Kay Schreiter, Kristin Breitschopf, Thomas Hübschle, Tina Jorsal, Tina Vilsbøll, Thorsten Schmidt, Stefan Theis, Filip K Knop, Philip Just Larsen, Jacob Jelsing
AIM: To determine whether intestinal expression of guanylate cyclase activator 2A (GUCA2A) and guanylate cyclase activator 2B (GUCA2B) genes is regulated in obese humans following Roux-en-Y gastric bypass (RYGB), and to evaluate the corresponding guanylin (GN) and uroguanylin (UGN) peptides for potentially contributing to the beneficial metabolic effects of RYGB. METHODS: Enteroendocrine cells were harvested peri- and post-RYGB, and GUCA2A/GUCA2B mRNA expression was compared...
December 28, 2017: Peptides
https://www.readbyqxmd.com/read/29287757/efficacy-of-adjuvant-weight-loss-medication-after-bariatric-surgery
#20
Zubaidah Nor Hanipah, Elie C Nasr, Emre Bucak, Philip R Schauer, Ali Aminian, Stacy A Brethauer, Derrick Cetin
BACKGROUND: Some patients do not achieve optimal weight loss or regain weight after bariatric surgery. In this study, we aimed to determine the effectiveness of adjuvant weight loss medications after surgery for this group of patients. SETTING: An academic medical center. METHODS: Weight changes of patients who received weight loss medications after bariatric surgery from 2012 to 2015 at a single center were studied. RESULTS: Weight loss medications prescribed for 209 patients were phentermine (n = 156, 74...
January 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
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