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https://www.readbyqxmd.com/read/28343308/the-nociceptive-withdrawal-response-of-the-foot-in-the-spinalized-rat-exhibits-limited-dependence-on-stimulus-location
#1
Corey L Cleland, Craig E Esquivel, Heath T Davis
The nociceptive withdrawal response (NWR) of the limb is a protective, multi-joint movement in response to noxious stimulation of the homonymous limb. Previous studies in animal models differed as to the dependence of the response direction and magnitude on stimulus location. The specific aim of our research was to use three-dimensional high-speed video to determine whether movement of the foot in response to heat stimuli delivered to the foot and lower leg depended on the location of the stimulus. In particular, we sought to determine whether the movement strategy was categorical or continuous...
March 25, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28340505/afferent-and-efferent-connections-of-the-interpeduncular-nucleus-with-special-reference-to-circuits-involving-the-habenula-and-raphe-nuclei
#2
Leandro B Lima, Debora Bueno, Fernanda Leite, Stefani Souza, Luciano Gonçalves, Isadora C Furigo, Jose Donato, Martin Metzger
The habenula is an epithalamic structure differentiated into two nuclear complexes, medial (MHb) and lateral habenula (LHb). Recently, MHb together with its primary target, the interpeduncular nucleus (IP), have been identified as major players in mediating the aversive effects of nicotine. However, structures downstream of the MHb-IP axis, including the median (MnR) and caudal dorsal raphe nucleus (DRC), may contribute to the behavioral effects of nicotine. The afferent and efferent connections of the IP have hitherto not been systematically investigated with sensitive tracers...
March 24, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28340228/dual-immunostain-with-satb2-and-ck20-differentiates-appendiceal-mucinous-neoplasms-from-ovarian-mucinous-neoplasms
#3
Zaibo Li, Rachel Roth, Jonathan B Rock, Amy Lehman, William L Marsh, Adrian Suarez, Wendy L Frankel
Objectives: Determination of the primary site of origin for mucinous neoplasms identified in the peritoneal and/or pelvic cavities may be challenging, with major differential diagnoses including appendiceal mucinous neoplasm (AMN) and ovarian mucinous neoplasm (OMN). Special AT-rich sequence binding protein 2 (SATB2) has been shown to be highly selectively expressed in the lower gastrointestinal tract, including the appendix. Methods: We investigated the utility of a dual stain (DS) with SATB2 or caudal type homeobox 2 (CDX2) and cytokeratin 20 (CK20) or villin in distinguishing AMNs from OMNs...
March 18, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28340021/phenamil-an-amiloride-derivative-restricts-long-bone-growth-and-alters-keeled-sternum-bone-architecture-in-growing-chickens
#4
Tara R Price, Kristin Moncada, Hector Leyva-Jimenez, Kye Won Park, Peter Tontonoz, Rosemary L Walzem
"Broiler-type" chickens are fast-grow-ing, heavy-bodied birds with high demands on bone quality. Phenamil increased mineralization in cultured murine mesenchymal stem cells. Phenamil effects were tested in 2 groups of weight and gender matched day-old broiler chickens (n = 13). Oral administration of 30 mg phenamil/kg body weight d 1 to 13 reduced growth of chicks d 5 to 14 (P = 0.002); with phenamil-treated (PT) chick body weight being 84% of vehicle-treated (VT) chicks' body weight on d 14. Tissues collected on d 15 showed that femur lengths and widths did not differ, but tibias from PT chicks were 6% shorter (P = 0...
March 3, 2017: Poultry Science
https://www.readbyqxmd.com/read/28339551/anticoagulant-and-antiplatelet-management-for-spinal-procedures-a-prospective-descriptive-study-and-interpretation-of-guidelines
#5
Bradly S Goodman, L McLean House, Sridhar Vallabhaneni, Srinivas Mallempati, Matthew R Willey, Matthew Thomas Smith
Setting.:  Epidural hematoma rarely complicates interventional spine procedures. While anticoagulant and antiplatelet drugs increase bleeding risk, cessation may precipitate serious thromboembolic events. The Spine Intervention Society (SIS) and American Society of Regional Anesthesia and Pain Medicine (ASRA) put forth guidelines that dissent with regard to management of hemostatically active agents during commonly performed spinal injections. Objective.:  To validate an antiplatelet/anticoagulant management table based on modifications of the SIS 2013 and ASRA 2015 guidelines...
October 6, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28339289/the-role-of-delineation-education-programs-for-improving-interobserver-variability-in-target-volume-delineation-in-gastric-cancer
#6
Cem Onal, Mustafa Cengiz, Ozan Cem Guler, Yemliha Dolek, Serdar Ozkok
OBJECTIVE: To assess whether delineation courses for radiation oncologists improve interobserver variability in target volume delineation for postoperative gastric cancer radiotherapy planning. METHODS: Twenty-nine radiation oncologists delineated target volumes in a gastric cancer patient. An experienced radiation oncologist lectured about delineation based on contouring atlas and delineation recommendations. After course, the radiation oncologists provided delineation for the same patient blind to the previous delineation...
March 24, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28337680/morphological-and-molecular-identification-of-habronema-spp-nematoda-habronematidae-from-donkeys-in-xinjiang-china-and-notes-on-the-taxonomical-status-of-habronema-majus-creplin-1849-and-h-microstoma-schneider-1866
#7
Rui Jian, Shi-Wei Wang, Wei-Xin Zhang, Lu-Ping Zhang
Habronematid nematodes were collected from the stomachs of donkeys, Equus asinus L., in the Tarim Basin, Xinjiang, China. After examination by light and scanning electron microscopy, Habronema muscae (Carter, 1861) and H. majus (Creplin, 1849) were identified. The morphology of our specimens representing H. muscae (Carter, 1861) agreed well with previous redescriptions in the shape of the lateral lips, origin of the lateral alae, ratio of left and right spicules, and number and arrangement of caudal papillae...
March 23, 2017: Systematic Parasitology
https://www.readbyqxmd.com/read/28337596/prolactin-regulation-of-the-hpa-axis-is-not-mediated-by-a-direct-action-upon-crh-neurons-evidence-from-the-rat-and-mouse
#8
Papillon Gustafson, Ilona Kokay, Tony Sapsford, Stephen Bunn, David Grattan
Centrally acting prolactin has been shown to have anti-stress effects by modulating the activity of the hypothalamic-pituitary-adrenal axis. We tested the hypothesis that prolactin directly targets hypothalamic corticotropin-releasing hormone (CRH) neurons. In situ hybridisation confirmed expression of mRNA encoding the long, but not the short, isoform of the prolactin receptor (PRLR) within the paraventricular nucleus (PVN) of the virgin rat; however, only 6% of CRH neurons expressed long-form Prlr mRNA. Examination of the functional response of CRH neurons to intracerebroventricular prolactin (500 ng) showed that these neurons did not respond with activation of phosphorylated signal transducer and activator of transcription 5 (pSTAT5), a marker of long-form PRLR activation...
March 23, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28337460/caudal-epidural-block-an-updated-review-of-anatomy-and-techniques
#9
REVIEW
Sheng-Chin Kao, Chia-Shiang Lin
Caudal epidural block is a commonly used technique for surgical anesthesia in children and chronic pain management in adults. It is performed by inserting a needle through the sacral hiatus to gain entrance into the sacral epidural space. Using conventional blind technique, the failure rate of caudal epidural block in adults is high even in experienced hands. This high failure rate could be attributed to anatomic variations that make locating sacral hiatus difficult. With the advent of fluoroscopy and ultrasound in guiding needle placement, the success rate of caudal epidural block has been markedly improved...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28332251/measuring-the-depth-of-the-caudal-epidural-space-to-prevent-dural-sac-puncture-during-caudal-block-in-children
#10
Hyun Jeong Lee, Ji Young Min, Hyun Il Kim, Hyo-Jin Byon
BACKGROUND: Caudal blocks are performed through the sacral hiatus in order to provide pain control in children undergoing lower abdominal surgery. During the block, it is important to avoid advancing the needle beyond the sacrococcygeal ligament too much to prevent unintended dural puncture. This study used demographic data to establish simple guidelines for predicting a safe needle depth in the caudal epidural space in children. METHODS: A total of 141 children under 12 years old who had undergone lumbar-sacral magnetic resonance imaging were included...
March 23, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28331974/neuronal-degeneration-in-the-dorsal-lateral-geniculate-nucleus-following-lesions-of-primary-visual-cortex-comparison-of-young-adult-and-geriatric-marmoset-monkeys
#11
Nafiseh Atapour, Katrina H Worthy, Leo L Lui, Hsin-Hao Yu, Marcello G P Rosa
Neuronal loss in the lateral geniculate nucleus (LGN) is a consequence of lesions of the primary visual cortex (V1). Despite the importance of this phenomenon in understanding the residual capacities of the primate visual system following V1 damage, few quantitative studies are available, and the effect of age at the time of lesion remains unknown. We compared the volume, neuronal number, and neuronal density in the LGN, 6-21 months after unilateral V1 lesions in marmoset monkeys. Stereological sampling techniques and neuronal nuclei (NeuN) staining were used to assess the effects of similar-sized lesions in adult (2-4 years) and geriatric (10-14 years) animals...
March 22, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28331933/conformation-of-the-proximal-tibia-and-cranial-cruciate-ligament-disease-in-small-breed-dogs
#12
Jan Janovec, Michal Kyllar, Duncan Midgley, Martin Owen
OBJECTIVES: To investigate the conformation of the proximal tibia in small breed dogs with and without cranial cruciate ligament disease (CCLD) and to identify morphologic abnormalities that may predispose to development of CCLD. METHODS: Mediolateral radiographs of the entire tibia of dogs <15 kg with surgically confirmed CCLD were retrospectively evaluated. Proximal tibial width (PTW), tibial plateau length (TPL), tibial plateau angle as described by Slocum and Slocum (sTPA), proximal tibial tuberosity angle (PTTA), tibial plateau angle as described by Inauen and colleagues (nTPA), and diaphyseal tibial width (DTW) were measured...
March 23, 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/28331412/a-review-of-the-pseudobarbus-afer-peters-1864-species-complex-teleostei-cyprinidae-in-the-eastern-cape-fold-ecoregion-of-south-africa
#13
Albert Chakona, Paul H Skelton
The Eastern Cape redfin, Pseudobarbus afer, has long been considered to be a single widespread and variable species occurring in multiple isolated river systems in the Cape Fold Ecoregion (CFE) at the southern tip of Africa. Mitochondrial cytochrome b and control region sequence data of individuals from populations currently assigned to Pseudobarbus afer across the species' distribution range revealed existence of four deeply divergent taxonomic units: (i) the Mandela lineage confined to the Sundays, Swartkops and Baakens river systems, (ii) the Krom lineage endemic to the Krom River system, (iii) the St Francis lineage occurring in the Gamtoos and adjacent river systems, and (iv) the Forest lineage occurring in several coastal river systems from the Tsitsikamma to the Klein Brak River system...
2017: ZooKeys
https://www.readbyqxmd.com/read/28331408/on-some-new-species-of-ancorabolidae-sars-1909-from-the-gulf-of-california-the-genera-ceratonotus-sars-1909-and-dendropsyllus-conroy-dalton-2003-crustacea-copepoda-harpacticoida
#14
Samuel Gómez, Karen Díaz
Two new species of two genera of the family Ancorabolidae, Ceratonotus elongatussp. n. and Dendropsyllus californiensissp. n., found at 1642 m and 1759 m depth, respectively, in the Southern Trough of Guaymas Basin, are described. Ceratonotus elongatussp. n. was attributed to that genus by a series of character states of which the lack of dendroid dorsal processes on the P6-bearing somite and the presence of such processes on the first abdominal somite were definitive. This species was observed to be very close to Ceratonotus thistlei Conroy-Dalton, 2003 from the San Diego Trough, and can be separated by a number of traits of which the elongated sensilla-bearing dorsal tubercles on the second abdominal somite in the new species was definitive...
2017: ZooKeys
https://www.readbyqxmd.com/read/28331115/spontaneous-multicentric-soft-tissue-sarcoma-in-a-captive-african-pygmy-hedgehog-atelerix-albiventris-case-report-and-literature-review
#15
Josué Díaz-Delgado, Roy Pool, Sharman Hoppes, Argine Cerezo, Óscar Quesada-Canales, George Stoica
This report describes the clinical, macroscopic, histopathological and immunohistological features of a spontaneous multicentric extraskeletal sarcoma in an adult male African hedgehog (Atelerix albiventris). It also provides a succinct up-to-date review on neoplasia in this species. On autopsy examination, main gross findings included a moderately demarcated cranial mass and a multilobulated, caudal intra-abdominal mass. The cranial mass had perforated the underlying temporal and occipital bones and had extended into the cranial vault and was compressing the surface of the cerebellum and cerebrum...
March 23, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28328630/fluorescein-isothiocyanate-a-novel-application-for-lymphatic-surgery
#16
Lisa Spiguel, Christiana Shaw, Adam Katz, Lifei Guo, Hung-Chi Chen, Bernard T Lee, Dhruv Singhal
The Lymphatic Microsurgical Preventing Healing Approach (LYMPHA) procedure entails performing a lymphovenous bypass (LVB) at the time of axillary lymph node dissection to reduce lymphedema risk. The two most common fluorophores utilized in LVB are blue dye and indocyanine green. We developed a novel application of fluorescein isothiocyanate for intraoperative lymphatic mapping. Our goal is to demonstrate the safety and efficacy of fluorescein isothiocyanate for this application. We reviewed a prospectively collected database on breast cancer patients who underwent LYMPHA from March to September 2015...
March 21, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28328605/unusual-association-cerebral-arteriovenous-malformation-and-chiari-type-i-malformation
#17
Hayri Ogul, Mecit Kantarci
Cerebral arteriovenous malformation (AVM) is a common type of cerebral vascular malformation. The imaging findings are enlarged vessels, thrombosed sinuses, and hemorrhage or gliosis on adjacent brain parenchyma. Magnetic resonance (MR) imaging can be used safely for diagnosis. Chiari type I malformation is characterized by a caudal descent of the cerebellar tonsil. Coincidence of cerebral AVM and Chiari type I malformation is very rare. In this paper, the authors report MR imaging findings of a patient with coincidence of cerebral AVM and Chiari type I malformation...
March 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28328000/cdx2-prognostic-value-in-stage-ii-iii-resected-colon-cancer-is-related-to-cms-classification
#18
C Pilati, J Taieb, R Balogoun, L Marisa, A de Reyniès, P Laurent-Puig
Caudal-type homeobox transcription factor 2 (CDX2) is involved in colon cancer (CC) oncogenesis and has been proposed as a prognostic biomarker in patients with stage II or III CC. We analyzed CDX2 expression in a series of 469 CC typed for the new international consensus molecular subtype (CMS) classification, and we confirmed results in a series of 90 CC. Here, we show that lack of CDX2 expression is only present in the mesenchymal subgroup (CMS4) and in MSI-immune tumors (CMS1) and not in CMS2 and CMS3 colon cancer...
February 27, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28327882/new-morphological-data-and-molecular-diagnostic-of-henneguya-friderici-myxozoa-myxobolidae-a-parasite-of-leporinus-friderici-osteichthyes-anostomidae-from-southeastern-brazil
#19
Letícia Poblete Vidal, José Luis Luque
The myxozoan Henneguya friderici is a parasite of the gills, intestine, kidney and liver of Leporinus friderici, a characiform fish belonging to the family Anostomidae. Forty-two specimens of L. friderici that had been caught in the Mogi Guaçú River, state of São Paulo, were studied. Elongated white plasmodia were found in the gill filaments of 10 host specimens (24%). The mature spores had an ellipsoidal body with polar capsules of equal size and caudal length greater than body length. This study also described 18S rDNA sequencing of H...
March 16, 2017: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/28324779/frontocingulate-cerebral-blood-flow-and-cerebrovascular-reactivity-associated-with-antidepressant-response-in-late-life-depression
#20
Margarita Abi Zeid Daou, Brian D Boyd, Manus J Donahue, Kimberly Albert, Warren D Taylor
BACKGROUND: Vascular pathology is common in late-life depression (LLD) and may contribute to alterations in cerebral blood flow (CBF) and cerebrovascular reactivity (CVR). In turn, such hemodynamic deficits may adversely affect brain function and clinical course. The goal of this study was to examine whether altered cerebral hemodynamics in depressed elders predicted antidepressant response. METHODS: 21 depressed elders completed cranial 3T MRI, including a pseudo-continuous Arterial Spin Labeling (pcASL) acquisition on both room air and during a hypercapnia challenge...
March 16, 2017: Journal of Affective Disorders
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