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JOURNAL ARTICLE
Federica Pecci, Luca Cantini, Valeria Cognigni, Fabiana Perrone, Giulia Mazzaschi, Veronica Agostinelli, Giulia Mentrasti, Elda Favari, Michele Maffezzoli, Alessio Cortellini, Francesca Rossi, Rebecca Chiariotti, Francesco Maria Venanzi, Giuseppe Lo Russo, Giulia Galli, Claudia Proto, Monica Ganzinelli, Francesca Tronconi, Francesca Morgese, Carla Campolucci, Marco Moretti, Arianna Vignini, Marcello Tiseo, Roberta Minari, Marco Luigi Bruno Rocchi, Sebastiano Buti, Rossana Berardi
BACKGROUND: Specific components of lipid profile seem to differently impact on immune activity against cancer and unraveling their prognostic role in patients with solid cancer treated with immune checkpoint inhibitors (ICIs) is needed. MATERIALS AND METHODS: We retrospectively collected baseline clinicopathological characteristics including circulating lipid profile (total cholesterol [TC], triglycerides [TG], low-density lipoproteins [LDL], high-density lipoproteins [HDL]) of patients with consecutive solid cancer treated with ICIs, and we investigated their role in predicting clinical outcomes...
October 5, 2023: Oncologist
#22
JOURNAL ARTICLE
Daniela Andriuta, Emmanuel Wiener, Alexandre Perron, Elisa Ouin, Ines Masmoudi, William Thibaut, Jeanne Martin, Martine Roussel, Jean-Marc Constans, Ardalan Aarabi, Olivier Godefroy
While neurodegenerative and vascular neurocognitive disorder (NCD) often co-occur, the contribution of vascular lesions, especially stroke lesions identified on MRI, to global cognition in a real-life memory clinic population remains unclear. The main objective of this retrospective study was to determine NCD neuroimaging correlates: the GM atrophy pattern and vascular lesions (especially stroke lesion localization by voxel-based lesion-symptom mapping, VLSM) in a memory clinic. We included 336 patients with mild or major NCD who underwent cerebral MRI and a neuropsychological assessment...
October 1, 2023: Journal of Neurology
#23
JOURNAL ARTICLE
Amelia Goncalves Dias, Anu Mehra, Thibaut Liernur, Thomas Ernandez, Noelle Junod Perron, Thierry Mach
The prevalence of renal colic is 20 % with a high recurrence rate. It remains a frequent reason for consultation in the emergency room. In case of uncertainty about the diagnosis, a decisional aide, the STONE score, can be used. Low-dose CT remains the standard, but studies show a role for ultrasound in the diagnosis to reduce the costs and cumulative effects of radiation. Most simple renal colics are treated with medical expulsive therapy which consists of anti-inflammatory, and an alpha blocker. It is important to identify patients who require urgent urological consultation or follow-up by urologists...
September 27, 2023: Revue Médicale Suisse
#24
JOURNAL ARTICLE
Jacques R Snyman, Luiz Aparecido Bortolotto, Luca Degli Esposti, Pathiyil Balagopalan Jayagopal, Alexandra O Konradi, Valentina Perrone, Claudio Borghi
OBJECTIVES: This analysis compared adherence, cardiovascular (CV) events and all-cause mortality incidence, and healthcare costs among hypertensive patients treated with perindopril (PER)/indapamide (IND)/amlodipine (AML) in single-pill combination (SPC) vs. multiple-pill combination, in a real-world setting in Italy. METHODS: In this observational retrospective analysis of Italian administrative databases, adult patients treated with PER/IND/AML between 2010 and 2020 were divided into two cohorts: single-pill vs...
January 1, 2024: Journal of Hypertension
#25
JOURNAL ARTICLE
Maud Parrot, Hamza Tajmouati, Vinicius Barros Ribeiro da Silva, Brian Ross Atwood, Robin Fourcade, Yann Gaston-Mathé, Nicolas Do Huu, Quentin Perron
Generative models are frequently used for de novo design in drug discovery projects to propose new molecules. However, the question of whether or not the generated molecules can be synthesized is not systematically taken into account during generation, even though being able to synthesize the generated molecules is a fundamental requirement for such methods to be useful in practice. Methods have been developed to estimate molecule "synthesizability", but, so far, there is no consensus on whether or not a molecule is synthesizable...
September 19, 2023: Journal of Cheminformatics
#26
JOURNAL ARTICLE
Piergiuseppe Agostoni, Francesca Romana Pluchinotta, Elisabetta Salvioni, Massimo Mapelli, Arianna Galotta, Alice Bonomi, Damiano Magrì, Enrico Perna, Stefania Paolillo, Ugo Corrà, Rosa Raimondo, Rocco Lagioia, Roberto Badagliacca, Pasquale Perrone Filardi, Anna Apostolo, Michele Senni, Annamaria Iorio, Michele Correale, Jeness Campodonico, Pietro Palermo, Mariantonietta Cicoira, Marco Metra, Marco Guazzi, Giuseppe Limongelli, Mauro Contini, Beatrice Pezzuto, Gianfranco Sinagra, Gianfranco Parati, Gaia Cattadori, Cosimo Carriere, Marco Cittar, Maria Vittoria Matassini, Andrea Salzano, Antonio Cittadini, Marco Masè, Francesco Bandera, Maurizio Bussotti, Irene Mattavelli, Federica Re, Carlo Vignati, Carlo Lombardi, Angela B Scardovi, Susanna Sciomer, Andrea Passantino, Michele Emdin, Andrea Di Lenarda, Claudio Passino, Caterina Santolamazza, Federica Moscucci, Denise Zaffalon, Massimo Piepoli
AIMS: Improvement of left ventricular ejection fraction is a major goal of heart failure (HF) treatment. However, data on clinical characteristics, exercise performance and prognosis in HF patients who improved ejection fraction (HFimpEF) are scarce. The study aimed to determine whether HFimpEF patients have a distinct clinical phenotype, biology and prognosis than HF patients with persistently reduced ejection fraction (pHFrEF). METHODS AND RESULTS: A total of 7948 patients enrolled in the Metabolic Exercise Cardiac Kidney Indexes (MECKI) score database were evaluated (median follow-up of 1490 days)...
November 2023: European Journal of Heart Failure
#27
JOURNAL ARTICLE
Alessandro Leonetti, Marianna Peroni, Virginia Agnetti, Fabiana Pratticò, Martina Manini, Alessandro Acunzo, Francesca Marverti, Simone Sulas, Elena Rapacchi, Giulia Mazzaschi, Fabiana Perrone, Paola Bordi, Sebastiano Buti, Marcello Tiseo
OBJECTIVES: Patients with lung cancer experience high rates of hospitalisation, mainly due to the high risk of complications that emerge during the natural history of the disease. We designed a retrospective, single-centre, observational study aimed at defining the clinical predictors of 30-day mortality in hospitalised patients with lung cancer. METHODS: Clinical records from the first admission of patients with lung cancer to the oncology ward of the University Hospital of Parma from 1 January 2017 to 1 January 2022 were collected...
September 4, 2023: BMJ Supportive & Palliative Care
#28
REVIEW
Giovanni Boscarino, Rossana Migliorino, Giulia Carbone, Giusy Davino, Valentina Giovanna Dell'Orto, Serafina Perrone, Nicola Principi, Susanna Esposito
Neonatal sepsis is a bacterial bloodstream infection leading to severe clinical manifestations frequently associated with death or irreversible long-term deficits. Antibiotics are the drug of choice to treat sepsis, regardless of age. In neonates, the lack of reliable criteria for a definite diagnosis and the supposition that an early antibiotic administration could reduce sepsis development in children at risk have led to a relevant antibiotic overuse for both prevention and therapy. The availability of biomarkers of neonatal sepsis that could alert the physician to an early diagnosis of neonatal sepsis could improve the short and long-term outcomes of true sepsis cases and reduce the indiscriminate and deleterious use of preventive antibiotics...
July 26, 2023: Antibiotics
#29
JOURNAL ARTICLE
Gennaro Lettieri, Carmela Marinaro, Rosaria Notariale, Pasquale Perrone, Martina Lombardi, Alessio Trotta, Jacopo Troisi, Marina Piscopo
Metabolomics is a method that provides an overview of the physiological and cellular state of a specific organism or tissue. This method is particularly useful for studying the influence the environment can have on organisms, especially those used as bio-indicators, e.g., Mytilus galloprovincialis . Nevertheless, a scarcity of data on the complete metabolic baseline of mussel tissues still exists, but more importantly, the effect of mussel exposure to certain heavy metals on spermatozoa is unknown, also considering that, in recent years, the reproductive system has proved to be very sensitive to the effects of environmental pollutants...
August 13, 2023: Metabolites
#30
JOURNAL ARTICLE
Antonio Ventriglio, Melania Severo, Annamaria Petito, Luigi Nappi, Salvatore Iuso, Mario Altamura, Valeria Sannicandro, Eleonora Milano, Giulia Arcidiacono, Melanie Di Salvatore, Fiammetta Gallone, Laura De Masi, Alessia Marconcini, Elisa Giannaccari, Giuseppe Maruotti, Giuseppe Luigi Palma, Mario Vicino, Antonio Perrone, Antonella Caroli, Isabella Di Pinto, Antonello Bellomo
BACKGROUND: Body Mass Index (BMI) is an informative factor on body fatness which has been associated to higher levels of Perinatal Depression (PD) and complications during pregnancy. We aimed to explore the impact of pre-pregnancy and postnatal BMI on the risk of Perinatal Depression and pregnancy outcomes among women recruited at their third trimester of pregnancy. METHODS: We report on findings from a large multi-centre study conducted in the South of Italy and involving 1611 women accessing three urban gynaecological departments from July to November 2020...
July 19, 2023: European Psychiatry: the Journal of the Association of European Psychiatrists
#31
JOURNAL ARTICLE
Christian Carulli, Matteo Innocenti, Rinaldo Tambasco, Alessandro Perrone, Roberto Civinini
(1) Background: Total Knee Arthroplasty (TKA) in patient with haemophilia (PWH) has usually been performed with the use of cobalt-chrome femoral and titanium tibial components, coupled with standard polyethylene (PE) inserts. The aim of this retrospective study was to evaluate the long-term outcomes and survival rates of TKA in a series of consecutive PWH affected by severe knee arthropathy at a single institution. (2) Methods: We followed 65 patients undergoing 91 TKA, implanted using the same implant, characterized by an oxidized zirconium femoral component, coupled with a titanium tibial component, and a highly crosslinked PE...
June 28, 2023: Journal of Clinical Medicine
#32
JOURNAL ARTICLE
Melissa Bersanelli, Elena Verzoni, Alessio Cortellini, Raffaele Giusti, Lorenzo Calvetti, Paola Ermacora, Marilena Di Napoli, Annamaria Catino, Valentina Guadalupi, Giorgia Guaitoli, Vieri Scotti, Francesca Mazzoni, Antonello Veccia, Pamela Francesca Guglielmini, Fabiana Perrone, Marco Maruzzo, Ernesto Rossi, Chiara Casadei, Vincenzo Montesarchio, Francesco Grossi, Mimma Rizzo, Maria Grazia Travagliato Liboria, Manlio Mencoboni, Fable Zustovich, Lucia Fratino, Caterina Accettura, Saverio Cinieri, Andrea Camerini, Mariella Sorarù, Paolo Andrea Zucali, Serena Ricciardi, Antonio Russo, Giorgia Negrini, Maria Chiara Banzi, Gaetano Lacidogna, Giuseppe Fornarini, Letizia Laera, Claudia Mucciarini, Matteo Santoni, Claudia Mosillo, Andrea Bonetti, Lucia Longo, Donata Sartori, Editta Baldini, Michele Guida, Mauro Iannopollo, Roberto Bordonaro, Maria Francesca Morelli, Pierosandro Tagliaferri, Massimiliano Spada, Anna Ceribelli, Rosa Rita Silva, Franco Nolè, Giordano Beretta, Petros Giovanis, Daniele Santini, Stefano Luzi Fedeli, Oriana Nanni, Evaristo Maiello, Roberto Labianca, Carmine Pinto, Alberto Clemente, Michele Tognetto, Ugo De Giorgi, Sandro Pignata, Massimo Di Maio, Sebastiano Buti, Diana Giannarelli
BACKGROUND: The prospective multicentre observational INVIDIa-2 study investigated the clinical effectiveness of influenza vaccination in patients with advanced cancer receiving immune checkpoint inhibitors (ICI). In this secondary analysis of the original trial, we aimed to assess the outcomes of patients to immunotherapy based on vaccine administration. METHODS: The original study enrolled patients with advanced solid tumours receiving ICI at 82 Italian Oncology Units from Oct 1, 2019, to Jan 31, 2020...
July 2023: EClinicalMedicine
#33
REVIEW
Liliana Dell'Osso, Ivan Mirko Cremone, Benedetta Nardi, Valeria Tognini, Lucrezia Castellani, Paola Perrone, Giulia Amatori, Barbara Carpita
Despite the relationship between Autism spectrum disorder (ASD) and personality disorders (PD) still being scarcely understood, recent investigations increased awareness about significant overlaps between some PD and autism spectrum conditions. In this framework, several studies suggested the presence of similarities between BPD and ASD symptoms and traits, based on the recent literature that increasingly reported increased comorbidity rates and significant symptomatologic overlaps between the two conditions...
May 26, 2023: Brain Sciences
#34
JOURNAL ARTICLE
Massimo Mapelli, Irene Mattavelli, Stefania Paolillo, Elisabetta Salvioni, Damiano Magrì, Arianna Galotta, Fabiana De Martino, Valentina Mantegazza, Carlo Vignati, Immacolata Esposito, Simona Dell'Aversana, Roberta Paolillo, Teresa Capovilla, Gloria Tamborini, Alessandro Alberto Nepitella, Pasquale Perrone Filardi, Piergiuseppe Agostoni
PURPOSE: Sacubitril/valsartan is a mainstay of the treatment of heart failure with reduced ejection fraction (HFrEF); however, its effects on exercise performance yielded conflicting results. Aim of our study was to evaluate the impact of sacubitril/valsartan on exercise parameters and echocardiographic and biomarker changes at different drug doses. METHODS: We prospectively enrolled consecutive HFrEF outpatients eligible to start sacubitril/valsartan. Patients underwent clinical assessment, cardiopulmonary exercise test (CPET), blood sampling, echocardiography, and completed the Kansas City Cardiomyopathy Questionnaire (KCCQ-12)...
June 27, 2023: European Journal of Clinical Pharmacology
#35
JOURNAL ARTICLE
Sabrina Faleschini, Myriam Doyon, Mélina Arguin, Jean-François Lepage, Henning Tiemeier, Ryan J Van Lieshout, Patrice Perron, Luigi Bouchard, Marie-France Hivert
OBJECTIVE: To examine the associations between exposure to gestational diabetes mellitus (GDM) and maternal glycemic markers during pregnancy and offspring behaviors at 3 and 5 years. We hypothesized that exposure to maternal hyperglycemia would be associated with more behavioral problems in offspring. METHODS: We included 548 mother-child pairs from the prospective pre-birth Gen3G cohort (Canada). Glycemic markers were measured during a 75 g oral glucose tolerance test (OGTT) in the second trimester of pregnancy...
June 9, 2023: Maternal and Child Health Journal
#36
JOURNAL ARTICLE
Validation of a new model of selective antegrade cerebral perfusion with circulatory arrest in rats.
Daniele Linardi, Romel Mani, Venanzio Di Nicola, Fabiola Perrone, Sara Martinazzi, Maddalena Tessari, Giuseppe Faggian, Giovanni Battista Luciani, Alessio Rungatscher
BACKGROUND: Selective antegrade cerebral perfusion (SACP) is adopted as an alternative to deep hypothermic circulatory arrest (DHCA) during aortic arch surgery. However, there is still no preclinical evidence to support the use of SACP associated with moderate hypothermia (28-30°C) instead of DHCA (18-20°C). The present study aims to develop a reliable and reproducible preclinical model of cardiopulmonary bypass (CPB) with SACP applicable for assessing the best temperature management...
June 5, 2023: Perfusion
#37
JOURNAL ARTICLE
Benoit Pairot de Fontenay, Marc Perron, Chantale Gendron, Pierre Langevin, Jean-Sébastien Roy
INTRODUCTION: Trunk muscle endurance (TME) tests are commonly used by clinicians to assess muscle performance changes in response to rehabilitation in patients with low back pain (LBP). The aim of this study was to assess the responsiveness of three TME-tests in patients with LBP and to evaluate the relationships between changes in TME and improvement in self-reported function. MATERIALS AND METHODS: Eighty-four LBP patients were evaluated at baseline and after completion of a 6-week training program...
2023: Frontiers in sports and active living
#38
JOURNAL ARTICLE
Maurizio Polano, Luca Bedon, Michele Dal Bo, Roberto Sorio, Michele Bartoletti, Elena De Mattia, Erika Cecchin, Carmela Pisano, Domenica Lorusso, Andrea Alberto Lissoni, Andrea De Censi, Sabrina Chiara Cecere, Paolo Scollo, Sergio Marchini, Laura Arenare, Ugo De Giorgi, Daniela Califano, Elena Biagioli, Paolo Chiodini, Francesco Perrone, Sandro Pignata, Giuseppe Toffoli
Pharmacogenomics studies how genes influence a person's response to treatment. When complex phenotypes are influenced by multiple genetic variations with little effect, a single piece of genetic information is often insufficient to explain this variability. The application of machine learning (ML) in pharmacogenomics holds great potential; namely, it can be used to unravel complicated genetic relationships that could explain response to therapy. In this study, ML techniques were used to investigate the relationship between genetic variations affecting more than 60 candidate genes and carboplatin-, taxane-, and bevacizumab-induced toxicities in 171 patients with ovarian cancer enrolled in the MITO-16A/MaNGO-OV2A trial...
May 27, 2023: Clinical Pharmacology and Therapeutics
#39
REVIEW
Antonio Curcio, Matteo Anselmino, Luigi Di Biase, Federico Migliore, Gerardo Nigro, Antonio Rapacciuolo, Domenico Sergi, Luca Tomasi, Roberto Pedrinelli, Giuseppe Mercuro, Pasquale Perrone Filardi, Ciro Indolfi
Thromboembolic events (TEE) associated with atrial fibrillation (AF) are highly recurrent and usually severe, causing permanent disability or, even, death. Previous data consistently showed significantly lower TEE in anticoagulated patients. While warfarin, a vitamin K antagonist, is still used worldwide, direct-acting oral anticoagulants (DOACs) have shown noninferiority to warfarin in the prevention of TEE, and represent, to date, the preferred treatment. DOACs present favorable pharmacokinetic, safety and efficacy profiles, especially among vulnerable patients including the elderly, those with renal dysfunction or previous TEE...
May 1, 2023: Journal of Cardiovascular Medicine
#40
JOURNAL ARTICLE
Ronald D Perrone, Dorothee Oberdhan, John Ouyang, Daniel G Bichet, Klemens Budde, Arlene B Chapman, Berenice Y Gitomer, Shigeo Horie, Albert C M Ong, Vicente E Torres, A Neil Turner, Holly Krasa
INTRODUCTION: The course of autosomal dominant polycystic kidney disease (ADPKD) varies greatly among affected individuals, necessitating natural history studies to characterize the determinants and effects of disease progression. Therefore, we conducted an observational, longitudinal study (OVERTURE; NCT01430494) of patients with ADPKD. METHODS: This prospective study enrolled a large international population ( N = 3409) encompassing a broad spectrum of ages (12-78 years), chronic kidney disease (CKD) stages (G1-G5), and Mayo imaging classifications (1A-1E)...
May 2023: KI Reports
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