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https://www.readbyqxmd.com/read/29614710/patient-reported-outcome-measures-proms-in-patients-undergoing-patellofemoral-arthroplasty-and-total-knee-replacement-a-comparative-study
#1
Fabio Luigi Perrone, Steffen Baron, Eduardo M Suero, Christian Lausmann, Daniel Kendoff, Akos Zahar, Thorsten Gehrke, Mustafa Citak
BACKGROUND: Incongruity in the evaluation of outcomes between patients and surgeons has led to an increasing utilization of patient-reported outcome measures (PROMs) as an evaluation method of outcome. OBJECTIVE: The aim of this study was to compare Oxford Knee Score (OKS), KOOS-PS and Kujala Score results in patients who received either PFA or TKA with and without patella resurfacing in the tretament of knee osteoarthritis. METHODS: A total of 50 patients (PFA = 19 patients; TKA with patelloplasty = 15 patients; TKA with patellar resurfacing = 16 patients) undergone surgery between 2011 and 2014 and were included for final analysis...
March 23, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29606114/prognostic-factors-of-a-favorable-outcome-following-a-supervised-exercise-program-for-soldiers-with-sub-acute-and-chronic-low-back-pain
#2
Marc Perron, Chantal Gendron, Pierre Langevin, Jean Leblond, Marianne Roos, Jean-Sébastien Roy
BACKGROUND: Low back pain (LBP) encompasses heterogeneous patients unlikely to respond to a unique treatment. Identifying sub-groups of LBP may help to improve treatment outcomes. This is a hypothesis-setting study designed to create a clinical prediction rule (CPR) that will predict favorable outcomes in soldiers with sub-acute and chronic LBP participating in a multi-station exercise program. METHODS: Military members with LBP participated in a supervised program comprising 7 stations each consisting of exercises of increasing difficulty...
April 2, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29605266/gastrointestinal-mucosal-development-and-injury-in-premature-lambs-supported-by-the-artificial-placenta
#3
Jennifer S McLeod, Joseph T Church, Prathusha Yerramilli, Megan A Coughlin, Elena M Perkins, Raja Rabah, Robert H Bartlett, Alvaro Rojas-Pena, Joel K Greenson, Erin E Perrone, George B Mychaliska
BACKGROUND: An Artificial Placenta (AP) utilizing extracorporeal life support (ECLS) could revolutionize care of extremely premature newborns, but its effects on gastrointestinal morphology and injury need investigation. METHODS: Lambs (116-121days GA, term=145; n=5) were delivered by C-section, cannulated for ECLS, had total parenteral nutrition (TPN) provided, and were supported for 7days before euthanasia. Early and Late Tissue Controls (ETC, n=5 and LTC, n=5) delivered at 115-121days and 125-131days, respectively, were immediately sacrificed...
March 8, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29560792/analysis-of-high-throughput-biological-data-using-their-rank-values
#4
Doulaye Dembélé
High-throughput biological technologies are routinely used to generate gene expression profiling or cytogenetics data. To achieve high performance, methods available in the literature become more specialized and often require high computational resources. Here, we propose a new versatile method based on the data-ordering rank values. We use linear algebra, the Perron-Frobenius theorem and also extend a method presented earlier for searching differentially expressed genes for the detection of recurrent copy number aberration...
January 1, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29493297/assessment-of-dna-damages-in-lymphocytes-of-agricultural-workers-exposed-to-pesticides-by-comet-assay-in-a-cross-sectional-study
#5
Graziana Intranuovo, Nunzia Schiavulli, Domenica Cavone, Francesco Birtolo, Pierluigi Cocco, Luigi Vimercati, Linda Macinagrossa, Annamaria Giordano, Tommasina Perrone, Giuseppe Ingravallo, Patrizio Mazza, Michela Strusi, Caterina Spinosa, Giorgina Specchia, Giovanni M Ferri
PURPOSE: To assess the predictive power of the comet assay in the context of occupational exposure to pesticides. MATERIALS AND METHODS: The recruited subjects completed a structured questionnaire and gave a blood sample. Exposure to pesticides was measured by means of an algorithm based on Dosemeci's work (Agricultural Health Study). Approximately 50 images were analyzed for each sample via fluorescence microscopy. The extent of DNA damage was estimated by tail moment (TM) and is the product of tail DNA (%) and tail Length...
March 2, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29462248/quality-of-life-analysis-of-the-mito-8-mango-bgog-ov1-ago-ovar2-16-engot-ov1-gcig-study-comparing-platinum-based-versus-non-platinum-based-chemotherapy-in-patients-with-partially-platinum-sensitive-recurrent-ovarian-cancer
#6
M C Piccirillo, G Scambia, A Bologna, S Signoriello, I Vergote, K Baumann, D Lorusso, V Murgia, R Sorio, G Ferrandina, C Sacco, G Cormio, E Breda, S Cinieri, D Natale, G Mangili, C Pisano, S C Cecere, M Di Napoli, V Salutari, F Raspagliesi, L Arenare, A Bergamini, J Bryce, G Daniele, C Gallo, S Pignata, F Perrone
Background: MITO-8 showed that prolonging platinum-free interval by introducing non-platinum-based chemotherapy (NPBC) does not improve prognosis of patients with partially platinum-sensitive recurrent ovarian cancer. Quality of life (QOL) was a secondary outcome. Patients and methods: Ovarian cancer patients recurring or progressing 6-12 months after previous platinum-based chemotherapy (PBC) were randomized to receive PBC or NPBC as first treatment. QOL was assessed at baseline, 3rd and 6th cycle, with the EORTC C-30 and OV-28 questionnaires...
February 16, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29460983/transcriptional-profiling-of-synovium-in-a-porcine-model-of-early-post-traumatic-osteoarthritis
#7
Jakob T Sieker, Benedikt L Proffen, Kimberly A Waller, Kaitlyn E Chin, Naga Padmini Karamchedu, Matthew R Akelman, Gabriel S Perrone, Ata M Kiapour, Johannes Konrad, Braden C Fleming, Martha M Murray
To determine the transcriptional profile of synovium during the molecular phase of post-traumatic osteoarthritis, anterior cruciate ligament transections (ACL) were performed in 36 Yucatan minipigs. Equal numbers were randomly assigned to no further treatment, ACL reconstruction or repair. Perimeniscal synovium for histopathology and RNA-sequencing was harvested at 1 and 4 weeks post-operatively and from six healthy control animals. Microscopic synovitis scores significantly worsened at 1 (p < 0.001) and 4 weeks (p = 0...
February 20, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29452889/anthropometric-and-biochemical-determinants-of-estimated-glomerular-filtration-rate-in-a-large-cohort-of-obese-children
#8
Pierluigi Marzuillo, Anna Grandone, Anna Di Sessa, Stefano Guarino, Mario Diplomatico, Giuseppina Rosaria Umano, Cesare Polito, Angela La Manna, Laura Perrone, Emanuele Miraglia Del Giudice
OBJECTIVE: We aimed to investigate which clinical and metabolic factors could influence the estimated glomerular filtration rate (eGFR) levels, evaluating a large population of obese children without suspect of primary kidney disease. DESIGN: Retrospective, cross-sectional study. SETTING: Pediatric university department. SUBJECTS: We enrolled 2,957 obese children and adolescents consecutively attending our department between January 2000 and 2017...
February 13, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29397584/mineralocorticoid-receptor-antagonists-for-heart-failure-a-real-life-observational-study
#9
Noemi Bruno, Gianfranco Sinagra, Stefania Paolillo, Alice Bonomi, Ugo Corrà, Massimo Piepoli, Fabrizio Veglia, Elisabetta Salvioni, Rocco Lagioia, Marco Metra, Giuseppe Limongelli, Gaia Cattadori, Angela B Scardovi, Valentina Carubelli, Domenico Scrutino, Roberto Badagliacca, Marco Guazzi, Rosa Raimondo, Piero Gentile, Damiano Magrì, Michele Correale, Gianfranco Parati, Federica Re, Mariantonietta Cicoira, Maria Frigerio, Maurizio Bussotti, Carlo Vignati, Fabrizio Oliva, Alessandro Mezzani, Giuseppe Vergaro, Andrea Di Lenarda, Claudio Passino, Susanna Sciomer, Giuseppe Pacileo, Roberto Ricci, Mauro Contini, Anna Apostolo, Pietro Palermo, Massimo Mapelli, Cosimo Carriere, Francesco Clemenza, Simone Binno, Romualdo Belardinelli, Carlo Lombardi, Pasquale Perrone Filardi, Michele Emdin, Piergiuseppe Agostoni
AIMS: Mineralocorticoid receptor antagonists (MRAs) have been demonstrated to improve outcomes in reduced ejection fraction heart failure (HFrEF) patients. However, MRAs added to conventional treatment may lead to worsening of renal function and hyperkalaemia. We investigated, in a population-based analysis, the long-term effects of MRA treatment in HFrEF patients. METHODS AND RESULTS: We analysed data of 6046 patients included in the Metabolic Exercise Cardiac Kidney Index score dataset...
February 4, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29239129/association-of-prenatal-exposure-to-gestational-diabetes-with-offspring-body-composition-and-regional-body-fat-distribution
#10
M Kearney, J Perron, I Marc, S J Weisnagel, A Tchernof, J Robitaille
The aim of this cohort study was to compare body composition and regional body fat distribution between children exposed (GDM+) or unexposed (GDM-) in utero to gestational diabetes mellitus (GDM) and to investigate the association with the glycaemic and the insulin profile. Data from 56 GDM+ and 30 GDM- were analysed. Height, weight and waist circumference were measured. Total and regional body composition was measured by dual-energy X-ray absorptiometry. Insulin, glucose and HbA1c were obtained from a fasting plasma sample, and the HOMA-IR index was calculated...
April 2018: Clinical Obesity
https://www.readbyqxmd.com/read/29150712/unacylated-ghrelin-and-obestatin-promising-biomarkers-of-protein-energy-wasting-in-children-with-chronic-kidney-disease
#11
Alice Monzani, Michela Perrone, Flavia Prodam, Stefania Moia, Giulia Genoni, Sara Testa, Fabio Paglialonga, Anna Rapa, Gianni Bona, Giovanni Montini, Alberto Edefonti
BACKGROUND: Impairment in orexigenic/anorexigenic hormone balance may be key in the pathogenesis of protein energy wasting in children with chronic kidney disease (CKD). Measurement of ghrelin and obestatin concentrations in children with CKD would help assess the potential contribution of these hormones to uremic protein energy wasting. METHODS: This was a cross-sectional case-control study. Acylated and unacylated ghrelin and obestatin were measured in 42 children on conservative treatment (CT), 20 children on hemodialysis, 48 pediatric renal transplant (RTx) recipients and 43 controls (CTR) (mean age 11...
November 18, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28993274/in-situ-hybridization-detection-methods-for-hpv16-e6-e7-mrna-in-identifying-transcriptionally-active-hpv-infection-of-oropharyngeal-carcinoma-an-updating
#12
Chiara C Volpi, Chiara M Ciniselli, Ambra V Gualeni, Maddalena Plebani, Salvatore Alfieri, Paolo Verderio, Laura Locati, Federica Perrone, Pasquale Quattrone, Antonino Carbone, Silvana Pilotti, Annunziata Gloghini
The aim of this study is comparing two in situ hybridization (ISH) detection methods for human papilloma virus (HPV) 16 E6/E7 mRNA, i.e. the RNAscope® 2.0 High Definition (HD) and the upgraded RNAscope® 2.5 HD version. The RNAscope® 2.5 HD has recently replaced the RNAscope® 2.0 HD detection kit. Therefore, this investigation starts from the need to analytically validate the new mRNA ISH assay and, possibly, to refine the current algorithm for HPV detection in oropharyngeal squamous cell carcinoma (OSCC) with the final goal to apply it to daily laboratory practice...
October 6, 2017: Human Pathology
https://www.readbyqxmd.com/read/28992127/can-we-further-enrich-autosomal-dominant-polycystic-kidney-disease-clinical-trials-for-rapidly-progressive-patients-application-of-the-propkd-score-in-the-tempo-trial
#13
Emilie Cornec-Le Gall, Jaime D Blais, Maria V Irazabal, Olivier Devuyst, Ron T Gansevoort, Ron D Perrone, Arlene B Chapman, Frank S Czerwiec, John Ouyang, Christina M Heyer, Sarah R Senum, Yannick Le Meur, Vicente E Torres, Peter C Harris
Background: The PROPKD score has been proposed to stratify the risk of progression to end-stage renal disease in autosomal dominant polycystic kidney disease (ADPKD) subjects. We aimed to assess its prognostic value in a genotyped subgroup of subjects from the Tolvaptan Phase 3 Efficacy and Safety Study in Autosomal Dominant Polycystic Kidney Disease (TEMPO3/4) trial. Methods: In the post hoc analysis, PKD1 and PKD2 were screened in 770 subjects and the PROPKD score was calculated in mutation-positive subjects (male: 1 point; hypertension <35 years: 2 points; first urologic event <35 years: 2 points; nontruncating PKD1 mutation: 2 points; truncating PKD1 mutation: 4 points)...
July 19, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28949086/multiparametric-prognostic-scores-in-chronic-heart-failure-with-reduced-ejection-fraction-a-long-term-comparison
#14
Piergiuseppe Agostoni, Stefania Paolillo, Massimo Mapelli, Piero Gentile, Elisabetta Salvioni, Fabrizio Veglia, Alice Bonomi, Ugo Corrà, Rocco Lagioia, Giuseppe Limongelli, Gianfranco Sinagra, Gaia Cattadori, Angela B Scardovi, Marco Metra, Valentina Carubelli, Domenico Scrutinio, Rosa Raimondo, Michele Emdin, Massimo Piepoli, Damiano Magrì, Gianfranco Parati, Sergio Caravita, Federica Re, Mariantonietta Cicoira, Chiara Minà, Michele Correale, Maria Frigerio, Maurizio Bussotti, Fabrizio Oliva, Elisa Battaia, Romualdo Belardinelli, Alessandro Mezzani, Luigi Pastormerlo, Marco Guazzi, Roberto Badagliacca, Andrea Di Lenarda, Claudio Passino, Susanna Sciomer, Elena Zambon, Giuseppe Pacileo, Roberto Ricci, Anna Apostolo, Pietro Palermo, Mauro Contini, Francesco Clemenza, Giovanni Marchese, Paola Gargiulo, Simone Binno, Carlo Lombardi, Andrea Passantino, Pasquale Perrone Filardi
AIMS: Risk stratification in heart failure (HF) is crucial for clinical and therapeutic management. A multiparametric approach is the best method to stratify prognosis. In 2012, the Metabolic Exercise test data combined with Cardiac and Kidney Indexes (MECKI) score was proposed to assess the risk of cardiovascular mortality and urgent heart transplantation. The aim of the present study was to compare the prognostic accuracy of MECKI score to that of HF Survival Score (HFSS) and Seattle HF Model (SHFM) in a large, multicentre cohort of HF patients with reduced ejection fraction...
September 26, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28918752/correlation-of-csf-flow-using-phase-contrast-mri-with-ventriculomegaly-and-csf-opening-pressure-in-mucopolysaccharidoses
#15
Amauri Dalla Corte, Carolina F M de Souza, Maurício Anés, Fabio K Maeda, Armelle Lokossou, Leonardo M Vedolin, Maria Gabriela Longo, Monica M Ferreira, Solanger G P Perrone, Olivier Balédent, Roberto Giugliani
BACKGROUND: Very little is known about the incidence and prevalence of hydrocephalus in patients with mucopolysaccharidoses (MPS). The biggest challenge is to distinguish communicating hydrocephalus from ventricular dilatation secondary to brain atrophy, because both conditions share common clinical and neuroradiological features. The main purpose of this study is to assess the relationship between ventriculomegaly, brain and cerebrospinal fluid (CSF) volumes, aqueductal and cervical CSF flows, and CSF opening pressure in MPS patients, and to provide potential biomarkers for abnormal CSF circulation...
September 18, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28915692/biomarker-analysis-of-the-phase-3-torch-trial-for-first-line-erlotinib-versus-chemotherapy-in-advanced-non-small-cell-lung-cancer-patients
#16
Lucia Kim, Mauro Saieg, Massimo Di Maio, Ciro Gallo, Charles Butts, Fortunato Ciardiello, Ronald Feld, Dengxiao Cheng, Vittorio Gebbia, Marco Angelo Burgio, Yasmin Alam, Simona Signoriello, Antonio Rossi, Natasha Leighl, Paolo Maione, Alessandro Morabito, Geoffrey Liu, Ming-Sound Tsao, Francesco Perrone, Cesare Gridelli
BACKGROUND: The TORCH phase III trial compared the efficacy of first-line erlotinib followed by chemotherapy at progression (experimental arm) with the reverse sequence (standard arm) in unselected advanced non-small cell lung cancer (NSCLC) patients. Here we report biomarker analyses. METHODS: EGFR and KRAS mutation, expression of EGFR family members and of cMET and PTEN and EGFR and ABCG2 germline polymorphisms were tested on tumor tissue or blood samples to either confirm previously proposed predictive role or describe it in an explorative setting...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28810480/nonverbal-intelligence-and-scholastic-performance-in-children-with-type-1-diabetes
#17
Alda Troncone, Antonietta Chianese, Angela Zanfardino, Crescenzo Cascella, Santino Confetto, Laura Perrone, Dario Iafusco
This study examined nonverbal intelligence and scholastic achievement in children with type 1 diabetes. In a retrospective case-control study, 69 children (35 males) ages 5-10 years with type 1 diabetes and 69 healthy controls matched to patients by age, gender and socioeconomic status were compared according to their performance on Raven's Coloured Progressive Matrices and their scholastic grades. No differences in nonverbal intelligence and grades were observed between children with type 1 diabetes and healthy control subjects...
June 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28671352/transcriptional-profiling-of-articular-cartilage-in-a-porcine-model-of-early-post-traumatic-osteoarthritis
#18
Jakob T Sieker, Benedikt L Proffen, Kimberly A Waller, Kaitlyn E Chin, Naga Padmini Karamchedu, Matthew R Akelman, Gabriel S Perrone, Ata M Kiapour, Johannes Konrad, Martha M Murray, Braden C Fleming
To identify the molecular pathophysiology present in early post-traumatic osteoarthritis (PTOA), the transcriptional profile of articular cartilage and its response to surgical PTOA induction were determined. Thirty six Yucatan minipigs underwent anterior cruciate ligament (ACL) transection and were randomly assigned in equal numbers to no further treatment, reconstruction or ligament repair. Cartilage was harvested at 1 and 4 weeks post-operatively and histology and RNA-sequencing were performed and compared to controls...
January 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28659829/risk-conferring-glutamatergic-genes-and-brain-glutamate-plus-glutamine-in-schizophrenia
#19
Juan R Bustillo, Veena Patel, Thomas Jones, Rex Jung, Nattida Payaknait, Clifford Qualls, Jose M Canive, Jingyu Liu, Nora Irma Perrone-Bizzozero, Vince D Calhoun, Jessica A Turner, Charles Gasparovic
BACKGROUND: The proton magnetic resonance spectroscopy ((1)H-MRS) signals from glutamate (or the combined glutamate and glutamine signal-Glx) have been found to be greater in various brain regions in people with schizophrenia. Recently, the Psychiatric Genetics Consortium reported that several common single-nucleotide polymorphisms (SNPs) in glutamate-related genes confer increased risk of schizophrenia. Here, we examined the relationship between presence of these risk polymorphisms and brain Glx levels in schizophrenia...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28624984/the-senhance%C3%A2-surgical-robotic-system-senhance-for-total-hysterectomy-in-obese-patients-a-pilot-study
#20
Salvatore Gueli Alletti, C Rossitto, S Cianci, E Perrone, S Pizzacalla, G Monterossi, G Vizzielli, S Gidaro, G Scambia
This pilot study was aimed to value the feasibility and safety of Senhance Robotic Platform for hysterectomy in obese patients. Ten obese patients (30 < BMI < 40) underwent elective Senhance total extrafascial hysterectomy with bilateral salpingo-oophorectomy at the Division of Gynecologic Oncology of "Policlinico A. Gemelli" Foundation, Rome, Italy. Perioperative and postoperative outcomes data were recorded. The median age was 60 years (range 51-75) and the median BMI was 33.3 kg/m(2) (range 30...
June 17, 2017: Journal of Robotic Surgery
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