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https://www.readbyqxmd.com/read/28351119/biotechnology-and-consumer-decision-making
#1
Joanna K Sax
Society is facing major challenges in climate change, health care and overall quality of life. Scientific advances to address these areas continue to grow, with overwhelming evidence that the application of highly tested forms of biotechnology is safe and effective. Despite scientific consensus in these areas, consumers appear reluctant to support their use. Research that helps to understand consumer decision-making and the public’s resistance to biotechnologies such as vaccines, fluoridated water programs and genetically engineered food, will provide great social value...
2017: Seton Hall Law Review
https://www.readbyqxmd.com/read/28351064/the-early-tech-development-course-experiential-commercialization-education-for-the-medical-academician
#2
Jonathan Servoss, Connie Chang, Jonathan Fay, Kevin Ward
PROBLEM: Research produced by medical academicians holds promise for developing into biomedical innovations in therapeutics, devices, diagnostics, and health care information technology; however, the road to biomedical innovation is fraught with risk, including the challenge of moving from basic research insight onto a viable commercialization path. Compounding this challenge is the growing demand on medical academicians to be more productive in their clinical, teaching, and research duties within a resource-constrained environment...
April 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28351014/phytostabilisation-of-severely-contaminated-mine-tailings-using-halophytes-and-field-addition-of-organic-and-inorganic-amendments
#3
T Pardo, M P Bernal, R Clemente
Phytostabilisation strategies have proven to be an efficient remediation option for mine tailings, but the adequate plant species and amendments have to be carefully selected. A remediation experiment was carried out at the semi-field level in tailings (pH 3.2, ≈1100, 4700 and 5000 mg kg(-1) of As, Pb and Zn, respectively) from the mining district of La Unión-Cartagena (SE Spain). A red mud derivative (Fe/Al oxides), its combination with compost, and hydrated lime (Ca hydroxide) were applied in field plots of 0...
March 21, 2017: Chemosphere
https://www.readbyqxmd.com/read/28350976/neuroendocrine-tumor-of-the-common-bile-duct-case-report
#4
C Raspanti, N Falco, V Silvestri, G Rotolo, S Bonventre, G Gulotta
Neuroendocrine tumors (NET) are a very heterogeneous group of neoplasms; in recent years we have seen an increase in their incidence (3.65 /100.000/year). They can be associated with hereditary endocrine syndromes (MEN, Von Hippel Lindau); they can occur at any age and the incidence is slightly higher in men than women. The aetiology of the neuroendocrine tumors is unclear; in most cases, inflammation of the bile ducts may be the underlying cause and for this reason, the initial patient's evaluation should be focused on the different aspects concerning the oncological one and the possible sequelae of the biliary obstructions that can evolve in biliary sepsis...
November 2016: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/28350952/future-advances-in-spine-surgery-the-aospine-north-america-perspective
#5
Michael G Fehlings, Christopher S Ahuja, Thomas Mroz, Wellington Hsu, James Harrop
This focus issue highlights state-of-the-art techniques, equipment, and practices in the modern era of spine surgery while providing a glimpse into the next generation of patient care. A broad range of topics are presented to cover the full spectrum of the field. Degenerative diseases are discussed in a series of 3 articles on (1) pathophysiology, management, and surgical approaches to degenerative cervical myelopathy; (2) novel approaches to degenerative thoracolumbar disease (eg, interspinous process spacers, minimally invasive/endoscopic approaches); and (3) animal models and emerging therapeutics in degenerative disk disease...
March 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28350946/emerging-techniques-in-degenerative-thoracolumbar-surgery
#6
Theodore J Choma, Thomas E Mroz, Christina L Goldstein, Paul Arnold, Mohammed F Shamji
There continue to be incremental advances in thoracolumbar spine surgery techniques in attempts to achieve more predictable outcomes, minimize risk of complications, speed recovery, and minimize the costs of these interventions. This paper reviews recent literature with regard to emerging techniques of interest in the surgical treatment of lumbar spinal stenosis, fusion fixation and graft material, degenerative lumbar spondylolisthesis, and thoracolumbar deformity and sacroiliac joint degeneration. There continue to be advances in minimal access options in these areas, although robust outcome data are heterogeneous in its support...
March 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28350940/recent-and-emerging-advances-in-spinal-deformity
#7
Justin S Smith, Christopher I Shaffrey, Shay Bess, Mohammed F Shamji, Darrel Brodke, Lawrence G Lenke, Michael G Fehlings, Virginie Lafage, Frank Schwab, Alexander R Vaccaro, Christopher P Ames
BACKGROUND: Over the last several decades, significant advances have occurred in the assessment and management of spinal deformity. OBJECTIVE: The primary focus of this narrative review is on recent advances in adult thoracic, thoracolumbar, and lumbar deformities, with additional discussions of advances in cervical deformity and pediatric deformity. METHODS: A review of recent literature was conducted. RESULTS: Advances in adult thoracic, thoracolumbar, and lumbar deformities reviewed include the growing applications of stereoradiography, development of new radiographic measures and improved understanding of radiographic alignment objectives, increasingly sophisticated tools for radiographic analysis, strategies to reduce the occurrence of common complications, and advances in minimally invasive techniques...
March 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28350897/transforming-concepts-into-clinical-trials-and-creating-a-multisite-network-the-leadership-and-operations-center-of-the-antibacterial-resistance-leadership-group
#8
Heather R Cross, Anthony Harris, Rebekka M Arias, Henry F Chip Chambers, Vance G Fowler
The Leadership and Operations Center (LOC) is responsible for facilitating, coordinating, and implementing the Antibacterial Resistance Leadership Group (ARLG) scientific agenda by engaging thought leaders; soliciting research proposals; and developing the processes, tools, and infrastructure required to operationalize studies and create and sustain the ARLG network. These efforts are ongoing as new projects are developed and the network expands and grows to address the ever-changing priorities in antibacterial resistance...
March 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28350836/perceived-psychosocial-stress-and-gestational-weight-gain-among-women-with-gestational-diabetes
#9
Ai Kubo, Assiamira Ferrara, Susan D Brown, Samantha F Ehrlich, Ai-Lin Tsai, Charles P Quesenberry, Yvonne Crites, Monique M Hedderson
Growing evidence links perceived stress-a potentially modifiable psychosocial risk factor-with health behaviors and obesity. Yet little is known about the relationship between stress during pregnancy and gestational weight gain, particularly among women with pregnancy complications. We conducted a cross-sectional analysis to examine associations between psychosocial stress during pregnancy and gestational weight gain among women with gestational diabetes. We used baseline data from the Gestational Diabetes's Effects on Moms (GEM) study: 1,353 women with gestational diabetes who delivered a term singleton within Kaiser Permanente Northern California were included...
2017: PloS One
https://www.readbyqxmd.com/read/28350798/research-priorities-for-harnessing-plant-microbiomes-in-sustainable-agriculture
#10
Posy E Busby, Chinmay Soman, Maggie R Wagner, Maren L Friesen, James Kremer, Alison Bennett, Mustafa Morsy, Jonathan A Eisen, Jan E Leach, Jeffery L Dangl
Feeding a growing world population amidst climate change requires optimizing the reliability, resource use, and environmental impacts of food production. One way to assist in achieving these goals is to integrate beneficial plant microbiomes-i.e., those enhancing plant growth, nutrient use efficiency, abiotic stress tolerance, and disease resistance-into agricultural production. This integration will require a large-scale effort among academic researchers, industry researchers, and farmers to understand and manage plant-microbiome interactions in the context of modern agricultural systems...
March 2017: PLoS Biology
https://www.readbyqxmd.com/read/28350563/predicting-the-mental-health-and-functioning-of-torture-survivors
#11
Suzan J Song, Andrew Subica, Charles Kaplan, Wietse Tol, Joop de Jong
The psychological effects of war represent a growing public health concern as more refugees and asylum seekers migrate across borders. This study investigates whether sociodemographic, premigration and postmigration, and psychosocial factors predict adverse psychiatric symptoms in refugees and asylum seekers exposed to torture (N = 278). Hierarchical linear regressions revealed that female sex, older age, and unstable housing predicted greater severity of anxiety, posttraumatic stress disorder (PTSD), and depression...
March 27, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28350521/clinical-activity-of-the-%C3%AE-secretase-inhibitor-pf-03084014-in-adults-with-desmoid-tumors-aggressive-fibromatosis
#12
Shivaani Kummar, Geraldine O'Sullivan Coyne, Khanh T Do, Baris Turkbey, Paul S Meltzer, Eric Polley, Peter L Choyke, Robert Meehan, Rasa Vilimas, Yvonne Horneffer, Lamin Juwara, Ann Lih, Amul Choudhary, Sandra A Mitchell, Lee J Helman, James H Doroshow, Alice P Chen
Purpose Desmoid tumors (aggressive fibromatosis) arise from connective tissue cells or fibroblasts. In general, they are slow growing and do not metastasize; however, locally aggressive desmoid tumors can cause severe morbidity and loss of function. Disease recurrence after surgery and/or radiation and diagnosis of multifocal desmoid tumors highlight the need to develop effective systemic treatments for this disease. In this study, we evaluate objective response rate after therapy with the γ-secretase inhibitor PF-03084014 in patients with recurrent, refractory, progressive desmoid tumors...
March 28, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28350436/potential-fluctuations-at-low-temperatures-in-mesoscopic-scale-smtio3-srtio3-smtio3-quantum-well-structures
#13
Will J Hardy, Brandon Isaac, Patrick Marshall, Evgeny Mikheev, Panpan Zhou, Susanne Stemmer, Douglas Natelson
Heterointerfaces of SrTiO3 with other transition metal oxides make up an intriguing family of systems with a bounty of coexisting and competing physical orders. Some examples, such as LaAlO3/SrTiO3, support a high carrier density electron gas at the interface whose electronic properties are determined by a combination of lattice distortions, spin-orbit coupling, defects, and various regimes of magnetic and charge ordering. Here, we study electronic transport in mesoscale devices made with heterostructures of SrTiO3 sandwiched between layers of SmTiO3, in which the transport properties can be tuned from a regime of Fermi-liquid like resistivity (ρ ∝ T(2)) to a non-Fermi liquid (ρ ∝ T(5/3)) by controlling the SrTiO3 thickness...
March 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28350434/stepwise-synthesis-of-metal-organic-frameworks
#14
Mathieu Bosch, Shuai Yuan, William Rutledge, Hong-Cai Zhou
Metal-organic frameworks (MOFs) are a category of porous materials that offer unparalleled control over their surface areas (demonstrated as higher than for any other material), pore characteristics, and functionalization. This allows them to be customized for exceptional performance in a wide variety of applications, most commonly including gas storage and separation, drug delivery, luminescence, or heterogeneous catalysis. In order to optimize biomimicry, controlled separations and storage of small molecules, and detailed testing of structure-property relationships, one major goal of MOF research is "rational design" or "pore engineering", or precise control of the placement of multiple functional groups in pores of chosen sizes and shapes...
March 28, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28346994/gc-ms-analysis-and-potential-cytotoxic-activity-of-calyptranthes-grandifolia-o-berg-calyptranthes-tricona-d-legrand-and-myrciaria-plinioides-d-legrand-essential-oil-in-raw264-7-and-cho-k1-cells
#15
D Faleiro, S M Immich, F Majolo, L Mayer, E M Ethur, M I Goettert
The search for new bioactive substances derived from natural products is daily growing. Among biologically active products used in therapeutic approaches, essential oils are described with wide range of therapeutic and pharmacological potential. Plants from Myrtaceae family have the presence of essential oils in its composition. Calyptranthes grandifolia, Calyptranthes tricona and Myrciaria plinioides species belong to this family and are used by the local population. However, there are no reports in the literature describing relevant characteristics about the potential and possible activities of these species...
March 22, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28346923/gut-brain-axis-and-behavior
#16
Clair R Martin, Emeran A Mayer
In the last 5 years, interest in the interactions among the gut microbiome, brain, and behavior has exploded. Preclinical evidence supports a role of the gut microbiome in behavioral responses associated with pain, emotion, social interactions, and food intake. Limited, but growing, clinical evidence comes primarily from associations of gut microbial composition and function to behavioral and clinical features and brain structure and function. Converging evidence suggests that the brain and the gut microbiota are in bidirectional communication...
2017: Nestlé Nutrition Institute Workshop Series
https://www.readbyqxmd.com/read/28346908/different-effects-of-biochar-and-a-nitrification-inhibitor-application-on-paddy-soil-denitrification-a-field-experiment-over-two-consecutive-rice-growing-seasons
#17
Shuwei Wang, Jun Shan, Yongqiu Xia, Quan Tang, Longlong Xia, Jinghui Lin, Xiaoyuan Yan
Biochar and nitrification inhibitors are increasingly being proposed as amendments to improve nitrogen use efficiency (NUE). However, their effects on soil denitrification and the major N loss in rice paddies over an entire rice-growing season are not well understood. In this study, using intact soil core incubation combined with N2/Ar technique, the impacts of biochar and a nitrification inhibitor (Ni), 2-chloro-6-(trichloromethyl)-pyridine, on rice yield and soil denitrification, as well as ammonia (NH3) volatilization, were investigated over two rice-growing seasons in the Taihu Lake region of China...
March 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28346900/growing-season-variability-in-carbon-dioxide-exchange-of-irrigated-and-rainfed-soybean-in-the-southern-united-states
#18
Pradeep Wagle, Prasanna H Gowda, Saseendran S Anapalli, Krishna N Reddy, Brian K Northup
Measurement of carbon dynamics of soybean (Glycine max L.) ecosystems outside Corn Belt of the United States (U.S.) is lacking. This study examines the seasonal variability of net ecosystem CO2 exchange (NEE) and its components (gross primary production, GPP and ecosystem respiration, ER), and relevant controlling environmental factors between rainfed (El Reno, Oklahoma) and irrigated (Stoneville, Mississippi) soybean fields in the southern U.S. during the 2016 growing season. Grain yield was about 1.6tha(-1) for rainfed soybean and 4...
March 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28346829/polymorphisms-in-the-glucocorticoid-receptor-gene-and-associations-with-glucocorticoid-induced-avascular-osteonecrosis-of-the-femoral-head
#19
Zhanqin Zhao, Yun Xue, Dun Hong, Hongjun Zhang, Zhigang Hu, Shunwu Fan, Haixiao Chen
AIMS: Individual sensitivity to glucocorticoid (GC) therapy might play a pivotal role in the development of GC-induced avascular necrosis of the femoral head (GANFH). In a growing number of studies, common polymorphisms of the glucocorticoid receptor gene (nuclear receptor subfamily 3 group C member 1 [NR3C1]) have been associated with variability in the individual sensitivity to GCs. However, whether the NR3C1 gene polymorphisms actually influence the susceptibility of GANFH remains unknown...
March 27, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28346823/design-and-monitoring-of-multi-arm-multi-stage-clinical-trials
#20
Pranab Ghosh, Lingyun Liu, P Senchaudhuri, Ping Gao, Cyrus Mehta
Two-arm group sequential designs have been widely used for over 40 years, especially for studies with mortality endpoints. The natural generalization of such designs to trials with multiple treatment arms and a common control (MAMS designs) has, however, been implemented rarely. While the statistical methodology for this extension is clear, the main limitation has been an efficient way to perform the computations. Past efforts were hampered by algorithms that were computationally explosive. With the increasing interest in adaptive designs, platform designs, and other innovative designs that involve multiple comparisons over multiple stages, the importance of MAMS designs is growing rapidly...
March 27, 2017: Biometrics
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