keyword
https://read.qxmd.com/read/38547416/characterizing-barriers-and-facilitators-of-metabolic-bariatric-surgery-tourism-a-systematic-review
#1
JOURNAL ARTICLE
Sharukh Zuberi, Abdullah Egiz, Hasan Iqbal, Periyathambi Jambulingam, Douglas Whitelaw, Tanveer Adil, Vigyan Jain, Omar Al-Taan, Aruna Munasinghe, Alan Askari, Mohamed K Aly, Fahad M Iqbal
BACKGROUND: Metabolic bariatric surgery tourism continues to rise and has become a growing concern for bariatric surgeons globally. With varying degrees of regulation, counselling and success, those that develop complications may have to deal with a multitude of challenges often distant from their country of operation. The aim of this study was to characterize the barriers and facilitators influencing individuals to undergo metabolic bariatric surgery tourism, in order to better understand the implications to the National Health Service and other healthcare systems...
March 2, 2024: British Journal of Surgery
https://read.qxmd.com/read/38547405/rapid-multiple-protein-sequence-search-by-parallel-and-heterogeneous-computation
#2
JOURNAL ARTICLE
Jiefu Li, Ziyuan Wang, Xuwei Fan, Ruijie Yao, Guoqing Zhang, Rui Fan, Zefeng Wang
MOTIVATION: Protein sequence database search and multiple sequence alignment (MSA) generation is a fundamental task in many bioinformatics analyses. As the data volume of sequences continues to grow rapidly, there is an increasing need for efficient and scalable multiple sequence query algorithms for super-large databases without expensive time and computational costs. RESULTS: We introduce Chorus, a novel protein sequence query system that leverages parallel model and heterogeneous computation architecture to enable users to query thousands of protein sequences concurrently against large protein databases on a desktop workstation...
March 28, 2024: Bioinformatics
https://read.qxmd.com/read/38547388/physiological-factors-associated-with-unsatisfied-inspiration-at-peak-exercise-in-healthy-adults
#3
JOURNAL ARTICLE
Olivia N Ferguson, Reid A Mitchell, Michele R Schaeffer, Andrew H Ramsook, Kyle G P J M Boyle, Satvir S Dhillon, Julia Zhang, Alanna S Hind, Dennis Jensen, Jordan A Guenette
INTRODUCTION: Contrary to common belief, a growing body of evidence suggests that unsatisfied inspiration (UI), an inherently uncomfortable quality of dyspnea, is experienced by ostensibly healthy adults during high-intensity exercise. Based on our understanding of the mechanisms of UI among people with chronic respiratory conditions, this analysis tested the hypothesis that the experience of UI at peak exercise in young, healthy adults reflects the combination of high ventilatory demand and critical inspiratory constraints...
March 28, 2024: Medicine and Science in Sports and Exercise
https://read.qxmd.com/read/38547356/increase-in-agricultural-derived-nh-x-and-decrease-in-coal-combustion-derived-no-x-result-in-atmospheric-particulate-n-nh-4-surpassing-n-no-3-in-the-south-china-sea
#4
JOURNAL ARTICLE
Zheng-En Zhang, Jun Li, Ruijie Zhang, Chongguo Tian, Zeyu Sun, Tingting Li, Minwei Han, Kefu Yu, Gan Zhang
The atmospheric deposition of anthropogenic active nitrogen significantly influences marine primary productivity and contributes to eutrophication. The form of nitrogen deposition has been evolving annually, alongside changes in human activities. A disparity arises between observation results and simulation conclusions due to the limited field observation and research in the ocean. To address this gap, our study undertook three field cruises in the South China Sea in 2021, the largest marginal sea of China...
March 28, 2024: Environmental Science & Technology
https://read.qxmd.com/read/38547323/sarcopenic-obesity-and-the-impact-on-bone-health
#5
JOURNAL ARTICLE
Silvia Migliaccio, Edoardo Mocini, Marianna Minnetti, Lorenzo Maria Donini
PURPOSE OF THE REVIEW: Sarcopenic obesity is a newly identified pathological entity defined by an increase in body fat mass with an associated sarcopenia, characterized by loss of muscle mass, strength, and function. Recently, the concomitant presence of skeletal alteration with sarcopenic obesity has been described leading to a new clinical entity defined osteosarcopenic obesity (OSO). Many studies have tried to unravel the metabolic complex mechanism leading to this clinical entity in order to understand the pathophysiology of this complex condition with the aim of posing an early diagnosis to improve the therapeutic approaches...
March 20, 2024: Current Opinion in Clinical Nutrition and Metabolic Care
https://read.qxmd.com/read/38547084/raising-awareness-of-uncertain-choices-in-empirical-data-analysis-a-teaching-concept-toward-replicable-research-practices
#6
JOURNAL ARTICLE
Maximilian M Mandl, Sabine Hoffmann, Sebastian Bieringer, Anna E Jacob, Marie Kraft, Simon Lemster, Anne-Laure Boulesteix
Throughout their education and when reading the scientific literature, students may get the impression that there is a unique and correct analysis strategy for every data analysis task and that this analysis strategy will always yield a significant and noteworthy result. This expectation conflicts with a growing realization that there is a multiplicity of possible analysis strategies in empirical research, which will lead to overoptimism and nonreplicable research findings if it is combined with result-dependent selective reporting...
March 2024: PLoS Computational Biology
https://read.qxmd.com/read/38547077/inoculation-of-pan02-cells-produces-tumor-nodules-in-mouse-pancreas-characterization-of-a-novel-orthotopic-pancreatic-ductal-adenocarcinoma-tumor-model-for-interventional-studies
#7
JOURNAL ARTICLE
James I Griffin, Xinyue Chen, Luqi Duan, Qingxin Mu, Rodney J Y Ho
Preclinical models of cancer are vital for assessing and predicting efficacies and toxicities of novel treatments prior to testing in human subjects. Current pancreatic tumor models exhibit variable growth rates, unpredictable tumor size after implantation in non-native tissues, or require surgical implantation. Surgical implantation in the pancreas may produce not only unpredictable tumor uptake but could also elicit additional inflammatory responses. In searching for a pancreatic carcinoma cell that can be introduced into a mouse via simple injection, we found that Pan02, a murine ductal pancreatic adenocarcinoma derived from a pancreatic lesion of a C57BL/6 mouse, inoculated peritoneally can consistently produce pancreatic tumors...
2024: PloS One
https://read.qxmd.com/read/38547070/observation-of-key-phenological-stages-of-hemlock-woolly-adelgid-hemiptera-adelgidae-using-citizen-science-as-a-tool-to-inform-research-and-management
#8
JOURNAL ARTICLE
Nicholas J Dietschler, Tonya D Bittner, Marshall Bigler Lefebvre, Jasmine Schmidt, Carrie S Jubb, Aryanna James, Scott M Salom, Mark C Whitmore
Increasing efficiency of data gathering at the landscape scale on the growing number of pests and pathogens threatening forests worldwide has potential to improve management outcomes. Citizen science is expanding, with growing support and utility in environmental and conservation fields. We present a case study showing how citizen science observations can be used to inform research and management of a devastating forest pest. Hemlock woolly adelgid, Adelges tsugae Annand (Hemiptera: Adelgidae), was introduced to eastern North America, leading to decline and mortality of eastern [Tsuga canadensis (L...
March 28, 2024: Journal of Economic Entomology
https://read.qxmd.com/read/38547050/insecticide-efficacy-and-emergence-timing-of-the-douglas-fir-twig-weevil
#9
JOURNAL ARTICLE
Thomas D Whitney, Gary Chastagner
The Douglas-fir twig weevil (Cylindrocopturus furnissi Buchanan) (Coleoptera: Curculionidae) has recently emerged as a significant pest of Christmas trees grown in the Pacific Northwest United States. The larvae girdle and disfigure twigs, which adversely affects tree marketability. Trees produced for export are also routinely destroyed for phytosanitary reasons when C. furnissi is discovered at border crossings. Due to historically being a sporadic and benign pest on planted and natural Douglas-fir (Psuedotsuga menziesii), there is a lack of chemical management options...
March 28, 2024: Journal of Economic Entomology
https://read.qxmd.com/read/38546909/left-behind-experiences-of-community-mental-health-center-clients-with-serious-mental-illness-during-the-covid-19-pandemic
#10
JOURNAL ARTICLE
Emily Leickly, Greg Townley
While some international qualitative research has interviewed people with serious mental illnesses (SMI) about their experiences in the initial months of the COVID-19 pandemic, few US studies have explored their experiences and perspectives as the pandemic has continued. Drawing from disability studies perspectives, this qualitative study conducted in 2022 explored the experiences of people with SMI seeking services at community mental health centers during the COVID-19 pandemic. Fifteen clients who identified as living with an SMI and were clients during March 2020 were interviewed...
March 28, 2024: Community Mental Health Journal
https://read.qxmd.com/read/38546814/synthesis-and-modulation-of-low-dimensional-transition-metal-chalcogenide-materials-via-atomic-substitution
#11
REVIEW
Xuan Wang, Akang Chen, XinLei Wu, Jiatao Zhang, Jichen Dong, Leining Zhang
In recent years, low-dimensional transition metal chalcogenide (TMC) materials have garnered growing research attention due to their superior electronic, optical, and catalytic properties compared to their bulk counterparts. The controllable synthesis and manipulation of these materials are crucial for tailoring their properties and unlocking their full potential in various applications. In this context, the atomic substitution method has emerged as a favorable approach. It involves the replacement of specific atoms within TMC structures with other elements and possesses the capability to regulate the compositions finely, crystal structures, and inherent properties of the resulting materials...
March 28, 2024: Nano-Micro Letters
https://read.qxmd.com/read/38546811/structure-based-multitargeted-docking-screening-pharmacokinetics-dft-and-dynamics-simulation-studies-reveal-mitoglitazone-as-a-potent-inhibitor-of-cellular-survival-and-stress-response-proteins-of-lung-cancer
#12
JOURNAL ARTICLE
Abdulkarim S Binshaya, Omar Saad Alkahtani, Fahad M Aldakheel, Ahmed Hjazi, Hassan H Almasoudi
Lung cancer is a disease in which lung cells grow abnormally and uncontrollably, and the cause of it is direct smoking, secondhand smoke, radon, asbestos, and certain chemicals. The worldwide leading cause of death is lung cancer, which is responsible for more than 1.8 million deaths yearly and is expected to rise to 2.2 million by 2030. The most common type of lung cancer is non-small cell lung cancer (NSCLC), which accounts for about 80% and small cell lung cancer (SCLC), which is more aggressive than NSCLC and is often diagnosed later and accounts for 20% of cases...
March 28, 2024: Medical Oncology
https://read.qxmd.com/read/38546752/prevalence-of-pretreatment-hiv-resistance-to-integrase-inhibitors-in-west-african-and-southeast-asian-countries
#13
JOURNAL ARTICLE
Avelin F Aghokeng, Nicole Ngo-Giang-Huong, Thu H K Huynh, Anoumou Y Dagnra, Thomas D'Aquin Toni, Almoustapha I Maiga, Kania Dramane, Sabrina Eymard-Duvernay, Marie-Laure Chaix, Vincent Calvez, Diane Descamps
OBJECTIVES: Integrase strand transfer inhibitors (INSTIs) have been recently recommended as the preferred first-line option for antiretroviral treatment initiators in low- and middle-income countries (LMICs) in response to the growing circulation of resistant HIV to non-nucleoside reverse transcriptase inhibitors (NNRTIs). In this study, we estimated the frequency of pretreatment drug resistance (PDR) to INSTIs in West Africa and Southeast Asia. MATERIALS AND METHODS: Using samples collected from 2015 to 2016, and previously used to assessed PI, NRTI and NNRTI resistance, we generated HIV integrase sequences and identified relevant INSTI PDR mutations using the Stanford and ANRS algorithms...
March 28, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38546738/food-security-as-a-basic-need-college-students-need-greater-support-from-institutional-administration
#14
JOURNAL ARTICLE
Matthew J Landry, Mateja R Savoie-Roskos, Virginia Gray, Georgianna Mann, Zubaida Qamar, Rebecca L Hagedorn-Hatfield, Cara L Cuite, Emily Heying, Lanae B Hood, Kendra OoNorasak
Food insecurity among college students has become a growing concern, with reports documenting its prevalence for over a decade. As the demographics of university and college students change, with more first-generation, nontraditional, and minority students, the risk of food insecurity is heightened. This viewpoint contends that food security is an essential basic need among college students, and when left unmet, it significantly impacts their well-being, resulting in an increased risk of poor academic performance or departure from higher education before degree completion...
March 28, 2024: Journal of American College Health: J of ACH
https://read.qxmd.com/read/38546714/social-media-use-in-dermatology-in-turkey-challenges-and-tips-for-patient-health
#15
JOURNAL ARTICLE
Ayse Serap Karadag, Basak Kandi, Berna Sanlı, Hande Ulusal, Hasan Basusta, Seray Sener, Sinem Calıka
Social media has established its place in our daily lives, especially with the advent of the COVID-19 pandemic. It has become the leading source of information for dermatological literacy on various topics, ranging from skin diseases to everyday skincare and cosmetic purposes in the present digital era. Accumulated evidence indicates that accurate medical content constitutes only a tiny fraction of the exponentially growing dermatological information on digital platforms, highlighting an unmet patient need for access to evidence-based information on social media...
March 28, 2024: JMIR dermatology
https://read.qxmd.com/read/38546687/a-rare-case-of-hereditary-multiple-exostoses-in-a-woman
#16
JOURNAL ARTICLE
Ranya Alawy Ghamri
Hereditary multiple exostosis (HME) is a rare genetic disorder characterized by multiple bony spurs or lumps, commonly affecting the long bones. This case report exposes the clinical presentation, diagnosis, and management of HME in a 28-year-old female nurse, who initially presented with persistent bilateral knee pain. After extensive evaluation involving orthopaedic and oncology specialists, the diagnosis of HME was made. Despite the discovery of multiple exostoses, the patient reported improvement following a tailored physiotherapy regimen...
March 2024: Orthopaedic Nursing
https://read.qxmd.com/read/38546574/developmental-cascades-from-maternal-preconception-stress-to-child-behavior-problems-testing-multilevel-preconception-prenatal-and-postnatal-influences
#17
JOURNAL ARTICLE
Gabrielle R Rinne, Margot E Barclay, Jennifer A Somers, Nicole E Mahrer, Madeleine U Shalowitz, Sharon Landesman Ramey, Christine Dunkel Schetter, Steve S Lee
Although maternal stress during pregnancy and even before conception shapes offspring risk for mental health problems, relatively little is known about the mechanisms through which these associations operate. In theory, preconception and prenatal stress may affect offspring mental health by influencing child responses to postnatal caregiving. To address this knowledge gap, this study had two aims. First, we examined associations between preconception and prenatal stress with child temperament profiles at age four using multilevel assessment of maternal perceived stress and stress physiology...
March 28, 2024: Developmental Psychology
https://read.qxmd.com/read/38546562/ethnic-inequality-between-arabs-and-jews-in-israel-in-global-life-satisfaction-a-social-determinants-examination-among-young-adults
#18
JOURNAL ARTICLE
Netta Achdut
Global life satisfaction (GLS), a core construct of subjective well-being, plays a vital role in positive development among young adults. Persistent inequality in subjective well-being across minority versus majority groups is a growing public health concern. However, research evidence on the minority-majority disparity in GLS among representative samples of young adults is scarce. Based on national data from Israel ( N = 2,405), this study examines (a) the association of multiple forms of economic (not in education, employment, or training status, subjective socioeconomic status indicators), social-relational (trust, discrimination, loneliness), and environmental determinants (neighborhood conditions) with GLS among young adults from a minority-majority (Israeli Arabs-Israeli Jews) perspective; (b) whether minority-majority disparity in GLS can be explained by differential health returns for the determinants considered across participants from the two groups; (c) whether minority-majority disparities in GLS persist when controlling for these determinants, suggesting the effect of ethnicity per se...
March 28, 2024: American Journal of Orthopsychiatry
https://read.qxmd.com/read/38546536/-i-would-have-my-children-participate-if-%C3%A2-perceptions-of-canadian-caregivers-towards-school-food-programs
#19
JOURNAL ARTICLE
Suvadra Datta Gupta, Nazeem Muhajarine, Rachel Engler-Stringer
Purpose: The Canadian federal government has expressed an intention to work with provinces and territories to develop a national school food program (SFP). This study aimed to explore caregivers' perception of attributes important to include in a future SFP. Methods: An online cross-sectional survey was conducted. Fifteen elementary schools from high, medium, or low median income neighbourhoods in Saskatoon were invited to participate. School principals sent a survey link to students' caregivers. The 37-item survey included an item with 15 statements asking caregivers to rate the importance of various components of a SFP...
March 28, 2024: Canadian Journal of Dietetic Practice and Research
https://read.qxmd.com/read/38546505/renal-hypokalemia-an-endocrine-perspective
#20
JOURNAL ARTICLE
Silas A Culver, Nawar Suleman, Varun Kavuru, Helmy M Siragy
The majority of disorders which cause renal potassium wasting present with abnormalities in adrenal hormone secretion. While these findings frequently lead patients to seek endocrine evaluation, clinicians often struggle to accurately diagnose these conditions, delaying treatment and adversely impacting patient care. At the same time, growing insight into the genetic and molecular basis of these disorders continues to improve their diagnosis and management. In this review we outline a practical integrated approach to the evaluation of renal hypokalemia syndromes that are seen in endocrine practice while highlighting recent advances in understanding of the genetics and pathophysiology behind them...
March 28, 2024: Journal of Clinical Endocrinology and Metabolism
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