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https://www.readbyqxmd.com/read/29342446/the-impact-of-happy-and-angry-faces-on-working-memory-in-depressed-adolescents
#1
Laura Wante, Sven C Mueller, Sofie Cromheeke, Caroline Braet
Recent cognitive models suggest that the ability to control emotional information in working memory (WM) may be implicated in the etiology and maintenance of depression. However, few studies have examined the effects of processing relevant and irrelevant emotional stimuli on WM performance in depressed adolescents. In the current study, depressed adolescents (n = 27) and healthy adolescents (n = 49) completed two versions of an emotional n-back task: a low WM load (0-back) task and a high WM load (2-back) task...
January 14, 2018: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29342353/synthesis-and-computational-studies-demonstrate-the-utility-of-an-intramolecular-styryl-diels-alder-reaction-and-bht-assisted-1-3-shift-to-construct-anticancer-dl-deoxypodophyllotoxin
#2
Diana I Saavedra, Benjamin D Rencher, Doo-Hyun Kwon, Stacey J Smith, Daniel H Ess, Merritt B Andrus
Deoxypodophyllotoxin is a secondary metabolite lignan possessing potent anticancer activity with potential as a precursor for known anticancer drugs, but its use is limited by scarcity from natural sources. We here report the total synthesis of racemic deoxypodophyllotoxin (DPT) in seven steps using an intramolecular styryl Diels-Alder reaction (ISDA) strategy uniquely suited to assemble the deoxypodophyllotoxin core. Computational studies are also reported for this reaction that demonstrate the ability to overcome the limitations of slow reactivity and electronic mismatch of the diene and dieneophile...
January 17, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29342324/different-atomic-terminations-associated-photocatalytic-nitrogen-fixation-of-bismuth-oxybromide-a-first-principles-study
#3
Hongxian Liu, Zhenxing Fang, Yongfei Su, Yuanli Suo, Shuping Huang, Yongfan Zhang, Kaining Ding
We have systematically investigated the electronic structures and activation capacities of BiOBr {001} facets with different atomic terminations by means of DFT methods. Our calculations reveal that oxygen vacancies (OVs) give a significant boost in band edges of the O-terminated BiOBr {001} facets, and excess electrons induced by OVs could exceed the reduction potentials of high-energy N2 intermediates. Interestingly, the Bi-terminated BiOBr {001} facets may be good candidates for photocatalytic nitrogen fixation due to the stronger activation ability of N2 molecules comparing with O-terminated BiOBr {001} facets with OVs...
January 17, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29342244/gli2-rescues-delays-in-brain-development-induced-by-kif3a-dysfunction
#4
Jia-Long Chen, Chia-Hsiang Chang, Jin-Wu Tsai
The primary cilium in neural stem cells plays distinct roles in different stages during cortical development. Ciliary dysfunctions in human (i.e., ciliopathy) cause developmental defects in multiple organs, including brain developmental delays, which lead to intellectual disabilities and cognitive deficits. However, effective treatment to this devastating developmental disorder is still lacking. Here, we first investigated the effects of ciliopathy on neural stem cells by knocking down Kif3a, a kinesin II motor required for ciliogenesis, in the neurogenic stage of cortical development by in utero electroporation of mouse embryos...
January 12, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29342226/don-t-judge-a-book-by-its-cover-examiner-expectancy-effects-predict-neuropsychological-performance-for-individuals-judged-as-chronic-cannabis-users
#5
Louise M Sodos, Rayna B Hirst, Jessica Watson, Dylan Vaughn
Objective: The experimenter expectancy effect confound remains largely unexplored in neuropsychological research and has never been investigated among cannabis users. This study investigated whether examiner expectancies of cannabis user status affected examinees' neuropsychological performance. Method: Participants included 41 cannabis users and 20 non-users. Before testing, examiners who were blind to participant user status privately rated whether they believed the examinee was a cannabis user or non-user...
January 12, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29342143/regulation-of-embryonic-haematopoietic-multipotency-by-ezh1
#6
Linda T Vo, Melissa A Kinney, Xin Liu, Yuannyu Zhang, Jessica Barragan, Patricia M Sousa, Deepak K Jha, Areum Han, Marcella Cesana, Zhen Shao, Trista E North, Stuart H Orkin, Sergei Doulatov, Jian Xu, George Q Daley
All haematopoietic cell lineages that circulate in the blood of adult mammals derive from multipotent haematopoietic stem cells (HSCs). By contrast, in the blood of mammalian embryos, lineage-restricted progenitors arise first, independently of HSCs, which only emerge later in gestation. As best defined in the mouse, 'primitive' progenitors first appear in the yolk sac at 7.5 days post-coitum. Subsequently, erythroid-myeloid progenitors that express fetal haemoglobin, as well as fetal lymphoid progenitors, develop in the yolk sac and the embryo proper, but these cells lack HSC potential...
January 17, 2018: Nature
https://www.readbyqxmd.com/read/29342095/preparation-of-cyano-substituted-tetraphenylethylene-derivatives-and-their-applications-in-solution-processable-oleds
#7
Xiaoyi Sun, Lele Zhao, Xiao Han, Hui Liu, Yu Gao, Yanchun Tao, Haiquan Zhang, Bing Yang, Ping Lu
Creation of organic luminescent materials with high solid-state efficiency is of vital importance for their applications in optoelectronic fields. Here, a series of AIE luminogens (AIE gens), (Z)-2,3-bis(4-(9,9-bis(6-(9H-carbazol-9-yl)hexyl)-9H-fluoren-2-yl)phenyl)-3-phenylacrylonitrile (SFC), and 2,3-bis(4-(9,9-bis(6-(9H-carbazol-9-yl)hexyl)-9H-fluoren-2-yl)phenyl)fumaronitrile (DFC), utilizing 2,3,3-triphenylacrylonitrile and 2,3-diphenylfumaronitrile as respective centers, are designed and synthesized by Suzuki coupling reactions with high yields...
January 17, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29342010/the-ever-expanding-saga-of-the-proprotein-convertases-and-their-roles-in-body-homeostasis-emphasis-on-novel-proprotein-convertase-subtilisin-kexin-number-9-functions-and-regulation
#8
Nabil G Seidah, Michel Chrétien, Majambu Mbikay
PURPOSE OF REVIEW: The nine members of the proprotein convertase family play major physiological roles during development and in the adult, and their dysregulation leads to various diseases. The primary objective of this article is to review recent findings on the clinical importance of some of these convertases concentrating mostly on PCSK9, the ninth member of the convertase family. This includes the transcriptional and translational regulation of PCSK9, its ability to enhance the degradation of LDL receptor (LDLR), and the implication of PCSK9 in inflammation and sepsis...
January 15, 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/29341945/lessons-about-causes-and-management-of-an-ebola-outbreak
#9
Aida Elargoubi, Anis W Belhaj Khelifa, Ons Haddad, Salma Mhalla, Nabil Sakly, Maha Mastouri
Ebola virus disease (EVD) is one of the deadliest viral diseases. It is characterized by a high mortality rate due to the lack of effective and safe treatments or vaccines and its ability to spread at an unstoppable pace. The West Africa outbreak ended but the disease may strike again at any time. The latest epidemic was, by far, the deadliest to date. The most concern was why this outbreak was so different from the previous ones. We proposed in this review firstly to summarize the principal causes of its unprecedented spread and secondly to identify the steps for an effective management approach of a future Ebola outbreak...
December 20, 2017: Folia Medica
https://www.readbyqxmd.com/read/29341915/influence-of-ligands-property-and-particle-size-of-gold-nanoparticles-on-the-protein-adsorption-and-corresponding-targeting-ability
#10
Wei Xiao, Jingyuan Xiong, Shuang Zhang, Yang Xiong, Huajin Zhang, Huile Gao
Nanoparticulated vesicles were widely used for carriers of drugs and imaging probes. To improve the targeting delivery efficiency of these vesicles, ligands were often functionalized onto their surfaces. However, the interaction between vesicles and plasma proteins may cover the ligands and hinder the targeting delivery. It is important to address the potential influence of ligands modification on plasma protein adsorption and the following targeting delivery. In this study, two common used ligands were chosen as the model: transferrin and RGD peptide...
January 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29341914/is-there-a-correlation-between-the-glass-forming-ability-of-a-drug-and-its-supersaturation-propensity
#11
Lasse Ingerslev Blaabjerg, Eleanor Lindenberg, Korbinian Löbmann, Holger Grohganz, Thomas Rades
The use of an enabling formulation technique, such as amorphization of a poorly water-soluble crystalline drug, can result in supersaturation with respect to the crystalline form of the drug and thus potentially in a higher degree of absorption after oral administration. The ease with which such drugs can be amorphized is known as their glass forming ability (GFA). In this study, a potential correlation between GFA and supersaturation propensity is investigated. The GFA of 23 different drugs was determined by melt quenching or milling the crystalline drugs to obtain their respective amorphous forms...
January 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29341911/an-efficient-pegylated-gene-delivery-system-with-improved-targeting-synergism-between-octaarginine-and-a-fusogenic-peptide
#12
Ikramy A Khalil, Hideyoshi Harashima
Because of their ability to translocate different cargos into cells, arginine-rich cell penetrating peptides (CPPs) are promising vehicles for drug and gene delivery. The use of CPP-based carriers, however, is hampered by the lack of specificity and by interactions with negative serum components. Polyethylene glycol (PEG) is used to decrease such non-specific interactions, albeit its use is associated with reduced transfection efficiency. In this study, we describe the development of PEGylated CPP-based gene carrier with an improved targeting and a high transfection activity...
January 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29341905/intensity-difference-limens-in-adult-cba-caj-mice-mus-musculus
#13
Anastasiya Kobrina, Katrina L Toal, Micheal L Dent
Mice have emerged as important models of auditory perception and acoustic communication. To study and model complex sound perception and communication, basic hearing abilities have to be established, yet intensity difference limens have not been measured in CBA/CAJ mice. Nine mice were trained using operant conditioning procedures with positive reinforcement to discriminate sound intensity across frequencies. Intensity difference limens were measured for 12, 16, 24, and 42 kHz tones at 10 and 30 dB sensation levels...
January 13, 2018: Behavioural Processes
https://www.readbyqxmd.com/read/29341892/premature-aging-in-behavior-and-immune-functions-in-tyrosine-hydroxylase-haploinsufficient-female-mice-a-longitudinal-study
#14
A Garrido, J Cruces, N Ceprián, C Hernández-Sánchez, M De la Fuente
Aging is accompanied by impairment in the nervous, immune, and endocrine systems as well as in neuroimmunoendocrine communication. In this context, there is an age-related alteration of the physiological response to acute stress, which is modulated by catecholamine (CA), final products of the sympathetic-adreno-medullary axis. The involvement of CA in essential functions of the nervous system is consistent with the neuropsychological deficits found in mice with haploinsufficiency (hemizygous; HZ) of tyrosine hydroxylase (TH) enzyme (TH-HZ)...
January 13, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29341857/development-of-visibility-forecasting-modelling-framework-for-the-lower-fraser-valley-of-british-columbia-using-canada-s-regional-air-quality-deterministic-prediction-system
#15
Rita So, Andrew Teakles, Jonathan Baik, Roxanne Vingarzan, Keith Jones
Visibility degradation, one of the most noticeable indicators of poor air quality, can occur despite relatively low levels of particulate matter when the risk to human health is low. The availability of timely and reliable visibility forecasts can provide a more comprehensive understanding of the anticipated air quality conditions to better inform local jurisdictions and the public. This paper describes the development of a visibility forecasting modelling framework, which leverages the existing air quality and meteorological forecasts from Canada's operational Regional Air Quality Deterministic Prediction System (RAQDPS) for the Lower Fraser Valley of British Columbia...
January 17, 2018: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/29341822/aripiprazole-long-acting-injectable-for-maintenance-treatment-of-bipolar-i-disorder-in-adults
#16
Arpit Aggarwal, Lindsey Schrimpf, John Lauriello
Bipolar I disorder is a serious and disabling psychiatric illness. It is associated with a significant reduction in quality of life and an increased risk for suicide. Pharmacotherapy is essential for both the acute and maintenance treatment of bi-polar I disorder. While multiple oral medications are recommended for the maintenance treatment, there are not many long-acting injectable medications approved for this indication. New treatments that would improve patient adherence have the potential for decreasing relapses and improving patients' ability to remain functional members of society...
January 2018: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/29341800/factors-associated-with-patient-satisfaction-in-an-outpatient-glaucoma-population
#17
Kamran Rahmatnejad, Jonathan S Myers, Megan E Falls, Sarah R Myers, Michael Waisbourd, Lisa A Hark
PURPOSE: To determine what metrics might impact satisfaction survey responses. METHODS: A 37-question survey was administered to 249 participants. Responses were correlated to demographics, clinical factors, weather conditions, and examination timing. RESULTS: Sample consists of 55.4% female and 73.9% white, and mean age was 65.1 years. Participants were assigned to: completely satisfied (77.9%) or not completely satisfied (22.1%) groups based on their rating of glaucoma specialist on a scale of 1-10, while 10 considered "completely satisfied" and less than 10 "not completely satisfied...
January 17, 2018: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/29341795/the-ability-to-provide-quality-chest-compressions-over-lacrosse-shoulder-pads
#18
Richard J Boergers, Thomas G Bowman, Monica Lininger
CONTEXT:   Performance of quality cardiopulmonary resuscitation is essential for improving patient outcomes. Performing compressions over football equipment inhibits compression depth and rate, but lacrosse equipment has not yet been studied. OBJECTIVE:   To assess the effect of lacrosse shoulder pads on the ability to provide quality chest compressions on simulation manikins. DESIGN:   Crossover study. SETTING:   Simulation laboratory...
January 17, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29341733/breaking-the-temporal-resolution-limit-by-superoscillating-optical-beats
#19
Yaniv Eliezer, Liran Hareli, Lilya Lobachinsky, Sahar Froim, Alon Bahabad
Band-limited functions can oscillate locally at an arbitrarily fast rate through an interference phenomenon known as superoscillations. Using an optical pulse with a superoscillatory envelope we experimentally break the temporal Fourier-transform focusing limit with a temporal feature that is approximately three times shorter than the duration of a transform-limited Gaussian pulse having a comparable bandwidth while maintaining 30% visibility. We experimentally demonstrate the ability of such signals to achieve temporal superresolution and show numerically in which cases such pulses can outperform transform-limited pulses...
July 28, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29341669/precision-measurement-of-time-reversal-symmetry-violation-with-laser-cooled-polyatomic-molecules
#20
Ivan Kozyryev, Nicholas R Hutzler
Precision searches for time-reversal symmetry violating interactions in polar molecules are extremely sensitive probes of high energy physics beyond the standard model. To extend the reach of these probes into the PeV regime, long coherence times and large count rates are necessary. Recent advances in laser cooling of polar molecules offer one important tool-optical trapping. However, the types of molecules that have been laser cooled so far do not have the highly desirable combination of features for new physics searches, such as the ability to fully polarize and the existence of internal comagnetometer states...
September 29, 2017: Physical Review Letters
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