keyword
https://read.qxmd.com/read/38378735/primary-results-of-the-brazilian-registry-of-atherothrombotic-disease-neat
#21
JOURNAL ARTICLE
Pedro G M de Barros E Silva, Charlene Troiani do Nascimento, Rodrigo Pinto Pedrosa, Marcelo Arruda Nakazone, Michel Ulloffo do Nascimento, Leiliandry de Araújo Melo, Osvaldo Lourenço Silva Júnior, Sérgio Luiz Zimmermann, Rodrigo Morel Vieira de Melo, Ricardo Reinaldo Bergo, Dalton Bertolim Precoma, Lucas Tramujas, Eduardo Gomes Lima, João Miguel Malta Dantas, Antônio Cláudio do Amaral Baruzzi, Ronald Luiz Gomes Flumignan, Maria Sanali Moura de Oliveira Paiva, Luís Henrique Wolff Gowdak, Priscila Nasser de Carvalho, José Albuquerque de Figueiredo Neto, Odilson Marcos Silvestre, Alexandre Fioranelli, Ricardo D 'Oliveira Vieira, Ana Clara Peneluppi Horak, Debora Harumi Kodama Miyada, Flávia Cristina Soares Kojima, Júlia Souza de Oliveira, Leila de Oliveira Silva, Ricardo Pavanello, Eduardo Ramacciotti, Renato D Lopes
There is limited contemporary prospective real-world evidence of patients with chronic arterial disease in Latin America. The Network to control atherothrombosis (NEAT) registry is a national prospective observational study of patients with known coronary (CAD) and/or peripheral arterial disease (PAD) in Brazil. A total of 2,005 patients were enrolled among 25 sites from September 2020 to March 2022. Patient characteristics, medications and laboratorial data were collected. Primary objective was to assess the proportion of patients who, at the initial visit, were in accordance with good medical practices (domains) for reducing cardiovascular risk in atherothrombotic disease...
February 20, 2024: Scientific Reports
https://read.qxmd.com/read/38374162/spectrophotometric-resolution-for-quantitative-analysis-of-aspirin-and-rivaroxaban-combination-therapy-in-biological-fluids-using-simple-and-eco-friendly-procedure
#22
JOURNAL ARTICLE
Heba M Mohamed, Hebatallah M Essam
Patients diagnosed with symptomatic peripheral artery disease (PAD) in the lower extremities have a higher likelihood of suffering from major vascular events. Recently, FDA has approved the combination therapy of aspirin (ASP) and rivaroxaban (ROX) to reduce acute limb ischemia and other comorbidities in (PAD) patients. Zero order and ratio absorption spectra were employed in three simple and accurate spectrophotometric techniques (dual wavelength (DW), ratio difference (RD) and derivative ratio (1 DD) for concurrent detection and quantification of ASP and ROX in their pure forms, lab synthetic mixtures and in biological fluid...
February 19, 2024: BMC chemistry
https://read.qxmd.com/read/38350973/diversity-in-randomized-clinical-trials-for-peripheral-artery-disease-a-systematic-review
#23
Chandler Long, Abimbola O Williams, Alysha M McGovern, Caroline M Jacobsen, Liesl M Hargens, Sue Duval, Michael R Jaff
BACKGROUND: Significant race and sex disparities exist in the prevalence, diagnosis, and outcomes of peripheral artery disease (PAD). However, clinical trials evaluating treatments for PAD often lack representative patient populations. This systematic review aims to summarize the demographic representation and enrollment strategies in clinical trials of lower-extremity endovascular interventions for PAD. METHODS: Following the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched multiple sources (Medline, EMBASE, Cochrane, Clinicaltrials...
February 13, 2024: International Journal for Equity in Health
https://read.qxmd.com/read/38307653/nonspecific-analgesics-combination-analgesics-and-antiemetics
#24
REVIEW
Daniele Martinelli, Maria Magdalena Pocora, Cristina Tassorelli
The acute treatment of migraine attacks should provide rapid, effective, and long-lasting symptom relief, causing minimal adverse effects. For this purpose, there are several specific and nonspecific acute treatments. In this chapter, we focus on molecules not specifically designed for migraines, including anti-inflammatory not specific analgesics, such as acetaminophen, acetylsalicylic acid, and other non-steroidal anti-inflammatory drugs (or COX-2 inhibitors); antinausea medications like metoclopramide or prochlorperazine, which can alleviate sickness and vomiting associated with migraines, and may also have a direct painkiller effect; combinations of simple analgesics or association of a painkiller with caffeine...
2024: Handbook of Clinical Neurology
https://read.qxmd.com/read/38307364/variability-in-guideline-directed-medical-therapy-across-sites-and-operators-and-long-term-mortality-and-amputation-outcomes-risk-in-patients-undergoing-peripheral-vascular-interventions
#25
JOURNAL ARTICLE
Kim G Smolderen, Gaëlle Romain, Jacob Cleman, Lindsey Scierka, Carlos Mena-Hurtado
BACKGROUND: The use of guideline-directed medical therapy (GDMT) in patients undergoing peripheral vascular interventions (PVIs) decreases the risk of death and amputation and may decrease hospital readmissions. The variability of GDMT prescription across sites and operators and the proportionality of risk is not well understood. We aimed to study the association between variability of GDMT prescription at the site and operator level and outcomes (including 90-day readmissions and 24-month all-cause mortality and major amputation)...
January 31, 2024: American Heart Journal
https://read.qxmd.com/read/38307233/poor-limb-prognosis-of-patients-with-chronic-limb-threatening-ischemia-on-hemodialysis-a-retrospective-observational-study-based-on-the-global-limb-anatomic-staging-system-glass
#26
JOURNAL ARTICLE
Takashi Endo, Toshio Takayama, Kazuhiro Miyahara, Takuro Shirasu, Yasuaki Mochizuki, Ryosuke Taniguchi, Katsuyuki Hoshina
OBJECTIVE: The Global Limb Anatomic Staging System (GLASS) has been widely used to evaluate patients with chronic limb-threatening ischemia (CLTI). As end-stage kidney disease (ESKD) is a well-known CLTI risk factor, we aimed to determine whether patients on hemodialysis (HD) have a worse limb prognosis than those without ESKD, considering the same GLASS background. METHODS: The data of 445 patients who underwent surgical and/or endovascular revascularization procedures for lower extremity ischemia were retrospectively collected in our division between 2005 and 2018...
January 31, 2024: Annals of Vascular Surgery
https://read.qxmd.com/read/38301372/use-of-a-rhodamine-based-chelator-in-a-microfluidic-paper-based-analytical-device-for-the-in-situ-copper-quantification-in-natural-waters
#27
JOURNAL ARTICLE
Juliana I S Aguiar, Susana O Ribeiro, Andreia Leite, Maria Rangel, António O S S Rangel, Raquel B R Mesquita
This work describes the development of a microfluidic paper-based analytical device (μPAD) for the determination of copper in fresh and marine waters. A functionalized rhodamine-based chelator was synthesized and used as a chromogenic reagent, forming a highly intense pink complex with the analyte. The aim was to create a paper device that offers optimal performance and provides in-situ, rapid and cost-effective analysis in line with World Health Organization guidelines. The influence on the determination of several physical and chemical parameters was evaluated aiming to achieve the best performance...
January 24, 2024: Talanta
https://read.qxmd.com/read/38301070/ingrown-toenails-a-survey-among-dermatologists-on-current-treatments
#28
JOURNAL ARTICLE
Corinna Dressler, Alexander Nast, Ruben Heuer, Christoph R Löser
BACKGROUND: To date, there is no formal consensus on how to treat ingrown toenails. Despite the risk of causing irreparable damage to the nail, highly invasive procedures are still common. Less-invasive, matrix-directed techniques with shorter downtime and high cure rates exist, but, perhaps because of a lack of awareness, appear not to have been universally adopted. OBJECTIVE: The authors' study sought to generate data on common practices in the treatment of ingrown toenails...
February 1, 2024: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://read.qxmd.com/read/38285331/real-world-risk-of-recurrent-cardiovascular-events-in-atherosclerotic-cardiovascular-disease-patients-with-ldl-c-above-guideline-recommended-threshold-a-retrospective-observational-study
#29
JOURNAL ARTICLE
Erin S Mackinnon, Lawrence A Leiter, Rajvi J Wani, Natasha Burke, Eileen Shaw, Kelcie Witges, Shaun G Goodman
INTRODUCTION: The 2021 Canadian Cardiovascular Society (CCS) guidelines recommend intensive low-density lipoprotein cholesterol (LDL-C) reduction for patients with atherosclerotic cardiovascular disease (ASCVD). For patients above LDL-C threshold on maximally tolerated statins, adding ezetimibe and/or a proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9i) is recommended. This population-based, real-world study examined cardiovascular (CV) events in patients with ASCVD who are on statins and above current guideline threshold LDL-C levels...
January 29, 2024: Cardiology and Therapy
https://read.qxmd.com/read/38280530/temporal-trends-in-characteristics-and-outcomes-after-myocardial-infarction-in-patients-with-and-without-peripheral-artery-disease-a-nationwide-register-based-follow-up-study
#30
JOURNAL ARTICLE
Patricia Jessen Andersen, Rubina Attar, Svend Eggert Jensen, Ashkan Eftekhari, Christoffer Polcwiartek, Marc Meller Søndergaard, Manan Pareek, Christian Torp-Pedersen, Kristian Kragholm
AIM: Patients with peripheral artery disease (PAD) represent a high-risk population with increased morbidity and mortality. We aimed to examine trends in myocardial infarction (MI), PAD and adverse clinical outcomes from years 2000 to 2019. METHODS: This nationwide Danish-based registry study included all patients with MI from years 2000-2019. Patients with PAD were compared to patients without PAD. Temporal changes in PAD prevalence over time was examined using the Cochrane-Armitage trend test, and Cox regression was used to test for between-group significance in all care and outcome measures...
January 25, 2024: International Journal of Cardiology
https://read.qxmd.com/read/38278371/comparison-of-direct-oral-anticoagulants-and-warfarin-in-chronic-limb-threatening-ischemia
#31
JOURNAL ARTICLE
Matthew Rockhold, Lauren Kunkel, Jordan L Lacoste, Thomas Szymanski, Paul Rothenberg, Pamela Zimmerman, Samantha Minc
OBJECTIVE: The role of direct oral anticoagulants (DOACs) in chronic limb-threatening ischemia after revascularization is unknown. Current evidence-based guidelines do not provide clear guidance on the role of anticoagulation or the selection of anticoagulant. Current practice is highly varied and based on provider and patient preference. The purpose of this study was to measure the impact of different anticoagulants on the incidence of major adverse limb events (MALEs) after revascularization for chronic limb-threatening ischemia, major adverse cardiovascular events (MACEs), all-cause mortality, and hospitalization for major bleeding events...
January 24, 2024: Journal of Vascular Surgery
https://read.qxmd.com/read/38269534/telephone-health-coaching-and-remote-exercise-monitoring-tegecoach-in-peripheral-arterial-occlusive-disease%C3%A2-a-randomized-controlled-trial
#32
RANDOMIZED CONTROLLED TRIAL
Farhad Rezvani, Dirk Heider, Hans-Helmut König, Lutz Herbarth, Patrick Steinisch, Franziska Schuhmann, Hannes Böbinger, Gundula Krack, Thomas Korth, Lara Thomsen, Daniela Patricia Chase, Robert Schreiber, Mark-Dominik Alscher, Benjamin Finger, Martin Härter, Jörg Dirmaier
BACKGROUND: Supervised exercise programs are commonly used to treat intermittent claudication (IC). Home-based exercise programs have been developed to lower barriers to participation. We studied the effects of one such program (TeGeCoach) on self-reported walking ability in patients with IC. METHODS: In a pragmatic, multicenter, randomized and controlled trial (registration number NCT03496948), 1982 patients with symptomatic IC, insured by one of three German statutory health-insurance carriers, received either telephone health coaching with remote exercise monitoring (TeGeCoach; n = 994) or routine care (n = 988)...
April 19, 2024: Deutsches Ärzteblatt International
https://read.qxmd.com/read/38248874/transcatheter-aortic-valve-implantation-access-sites-same-goals-distinct-aspects-various-merits-and-demerits
#33
REVIEW
Odysseas Katsaros, Anastasios Apostolos, Nikolaos Ktenopoulos, Leonidas Koliastasis, Ioannis Kachrimanidis, Maria Drakopoulou, Theofanis Korovesis, Antonios Karanasos, Sotirios Tsalamandris, George Latsios, Andreas Synetos, Konstantinos Tsioufis, Konstantinos Toutouzas
Transcatheter aortic valve implantation (TAVI) has been established as a safe and efficacious treatment for patients with severe symptomatic aortic stenosis (AS). Despite being initially developed and indicated for high-surgical-risk patients, it is now offered to low-risk populations based on the results of large randomized controlled trials. The most common access sites in the vast majority of patients undergoing TAVI are the common femoral arteries; however, 10-20% of the patients treated with TAVI require an alternative access route, mainly due to peripheral atherosclerotic disease or complex anatomy...
December 22, 2023: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38244007/below-the-knee-endovascular-revascularization-a-position-statement
#34
REVIEW
Jun Li, Ramon Varcoe, Marco Manzi, Steven Kum, Osamu Iida, Andrej Schmidt, Mehdi H Shishehbor
Patients with chronic limb-threatening ischemia, the terminal stage of peripheral artery disease, are frequently afflicted by below-the-knee disease. Although all patients should receive guideline-directed medical therapy, restoration of inline flow is oftentimes necessary to avoid limb loss. Proper patient selection and proficiency in endovascular techniques for below-the-knee revascularization are intended to prevent major amputation and promote wound healing. This review, a consensus among an international panel of experienced operators, provides guidance on these challenges from an endovascular perspective and offers techniques to navigate this complex disease process...
December 29, 2023: JACC. Cardiovascular Interventions
https://read.qxmd.com/read/38224837/dyslipidemia-and-peripheral-arterial-disease
#35
JOURNAL ARTICLE
Dr Ajay Yadav, Dr Vivek Sawant, Dr Varinder Singh Bedi, Dr Kanupriya Yadav
Peripheral arterial disease (PAD) affects 12 % of adult population and is increasing globally and in India. Peripheral arterial disease when associated with atherosclerosis in two or more other arterial beds such as coronary artery disease (CAD), mesenteric/renal artery and cerebrovascular disease (CVD), is known as polyvascular disease. The Reduction of Atherothrombosis for Continued Health (REACH) registry reported that 1 out of 6 patients had multi-vascular bed involvement. Progression of PAD to critical limb ischaemia (CLI) is seen in 1 % of affected patients per year, but patients who progress to CLI may have a 10- to 15-fold increased risk of cardiovascular death...
January 13, 2024: Indian Heart Journal
https://read.qxmd.com/read/38213115/exploring-canadian-genetic-counselors-perspectives-and-experiences-with-discussing-medical-assistance-in-dying-maid
#36
JOURNAL ARTICLE
Rebecca C Candlish, Susan Creighton, Daryl Pullman, Alison M Elliott
Medical assistance in dying (MAiD) is the Canadian equivalent of Physician aid-in-dying (PAD) in the United States. Through changes to the eligibility criteria for MAiD in 2021, Canada now has one of the most permissive assisted dying regimens in the world. This study describes Canadian genetic counselors' experiences, knowledge, and preparedness to discuss MAiD with their patients. Survey responses were collected from Canadian genetic counselors (n = 44) and were followed by semi-structured interviews with 14 survey participants...
January 11, 2024: Journal of Genetic Counseling
https://read.qxmd.com/read/38193764/clinical-impact-of-the-implementation-strategies-used-to-apply-the-2013-pain-agitation-sedation-delirium-or-2018-pain-agitation-sedation-delirium-immobility-sleep-disruption-guideline-recommendations-a-systematic-review-and-meta-analysis
#37
JOURNAL ARTICLE
Nicole E Hume, Isabelle Zerfas, Adrian Wong, Michele Klein-Fedyshin, Pamela L Smithburger, Mitchell S Buckley, John W Devlin, Sandra L Kane-Gill
OBJECTIVES: To summarize the effectiveness of implementation strategies for ICU execution of recommendations from the 2013 Pain, Agitation/Sedation, Delirium (PAD) or 2018 PAD, Immobility, Sleep Disruption (PADIS) guidelines. DATA SOURCES: PubMed, CINAHL, Scopus, and Web of Science were searched from January 2012 to August 2023. The protocol was registered with PROSPERO (CRD42020175268). STUDY SELECTION: Articles were included if: 1) design was randomized or cohort, 2) adult population evaluated, 3) employed recommendations from greater than or equal to two PAD/PADIS domains, and 4) evaluated greater than or equal to 1 of the following outcome(s): short-term mortality, delirium occurrence, mechanical ventilation (MV) duration, or ICU length of stay (LOS)...
January 9, 2024: Critical Care Medicine
https://read.qxmd.com/read/38184640/intra-aortic-balloon-pump-still-has-a-role-in-late-onset-myocardial-infarction-complicated-by-ventricular-septal-rupture-with-intractable-heart-failure-a-case-report
#38
JOURNAL ARTICLE
Mochamad Yusuf Alsagaff, Oky Revianto, Yan Efrata Sembiring, Muhammad Insani Ilman, Ryan Enast Intan
BACKGROUND: The current guidelines have discouraged the routine use of intra-aortic balloon pump (IABP) in cardiogenic shock complicating acute coronary syndrome (ACS). Since then, the trend of IABP utilization in ACS has been declining. Nevertheless, the guidelines still preserve the recommendation of IABP use in hemodynamic instability or cardiogenic shock caused by post myocardial infarction (MI) ventricular septal rupture (VSR). CASE PRESENTATION: A 46-years-old diabetic Southeast Asian female was referred from a peripheral facility with intractable heart failure despite treatment with vasoactive agents and diuretics for five days...
January 7, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38182277/generalisability-of-trials-on-antithrombotic-treatment-intensification-in-patients-with-cardiovascular-disease
#39
JOURNAL ARTICLE
Maria C Castelijns, Steven H J Hageman, Martin Teraa, Manon G van der Meer, Jan Westerink, Jurrien Ten Berg, Frank L J Visseren
OBJECTIVE: Assessment of generalisability of guideline-informing trials on antithrombotic treatment intensification to real-world patients with cardiovascular disease (CVD). METHODS: Inclusion and exclusion criteria of the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS), Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA), Prevention of Cardiovascular events in Patients with Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin-Thrombolysis in Myocardial Infarction (PEGASUS-TIMI) and Dual Antiplatelet Therapy (DAPT) study were applied to coronary artery disease (CAD) and/or peripheral artery disease (PAD) patients from Utrecht Cardiovascular Cohort-Second Manifestations of Arterial Disease (UCC-SMART) to determine real-world eligibility...
January 5, 2024: Heart
https://read.qxmd.com/read/38171907/cardiovascular-risk-age-reflects-arterial-status-middle-aged-people-showed-equivalent-arterial-stiffness-to-older-people-in-the-same-risk-category
#40
JOURNAL ARTICLE
Lia Alves-Cabratosa, Marc Elosua-Bayés, Ruth Martí-Lluch, Jordi Blanch, Èric Tornabell-Noguera, Maria Garcia-Gil, Anna Ponjoan, Maria Grau, Francesc Ribas-Aulinas, Lluís Zacarías-Pons, Jaume Marrugat, Rafel Ramos
AIM: The concept of risk age may help overcome an excessive weight of age in cardiovascular risk functions. This study aimed to evaluate the equivalence of risk age with arterial stiffness by comparing people with increased risk age and individuals with the same chronological and risk age. In order to materialize this aim, we categorized individuals based on cardiovascular risk and compared groups with increased risk factors (other than age) and groups with normal levels. METHODS: This is a cross-sectional population-level study carried out in Girona province within the context of the REGICOR study (Girona Heart Registry)...
December 28, 2023: Journal of Atherosclerosis and Thrombosis
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