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https://www.readbyqxmd.com/read/29148128/step-ergometer-training-augmented-with-functional-electrical-stimulation-in-individuals-with-chronic-spinal-cord-injury-a-feasibility-study
#1
Candy Tefertiller, Don Gerber
Spinal cord injury (SCI) often results in loss of upright mobility and independence subsequently challenging rehabilitation practitioners for meaningful intervention strategies. The objective of this study was to evaluate the feasibility and potential impact on walking function of the stimulation and ergometer training protocol (STEP) in chronic SCI. Fourteen individuals with a chronic motor incomplete SCI (>1-year post injury) were enrolled in the study. The intervention consisted of a 12-week walking training program delivered three times per week from 20 up to 45 min in combination with 10 channels of FES on a step ergometer...
November 2017: Artificial Organs
https://www.readbyqxmd.com/read/29142031/activity-limitations-in-patients-with-axial-spondyloarthritis-a-role-for-fear-of-movement-and-re-injury-beliefs
#2
Thijs W Swinnen, Johan W S Vlaeyen, Wim Dankaerts, Rene Westhovens, Kurt de Vlam
OBJECTIVE: To determine whether fear of movement and (re)injury [FOM/(R)I] beliefs, measured with the Tampa Scale for Kinesiophobia 11-item version (TSK-11), influence activity limitations and mediate the relationship between pain severity and activity limitations in axial spondyloarthritis (axSpA). METHODS: In 173 patients with axSpA, these data were collected: sex, body mass index, disease duration, medication, activity limitations (BASFI; Bath Ankylosing Spondylitis Functional Index), disease activity [Bath Ankylosing Spondylitis Disease Activity Index (BASDAI); BASDAIinf, items 5 and 6; BASDAIpain, items 2 and 3; C-reactive protein and physician's global assessment], spinal mobility (BASMI; Bath Ankylosing Spondylitis Metrology Index), and FOM/(R)I (TSK-11)...
November 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29141611/are-paraspinous-intramuscular-injections-of-botulinum-toxin-a-bont-a-efficient-in-the-treatment-of-chronic-low-back-pain-a-randomised-double-blinded-crossover-trial
#3
Mélanie Cogné, Hervé Petit, Alexandre Creuzé, Dominique Liguoro, Mathieu de Seze
BACKGROUND: Treatment for patients with chronic low-back pain (LBP) is a public health issue. Intramuscular injections of botulinum toxin A (BoNT-A) have shown an analgesic effect on LBP in two previous randomized controlled studies. The objective of the study was to verify the efficacy of paravertebral injections of BoNT-A in patients with LBP. METHODS: Patients were included in this phase 3 randomized double-blinded trial comparing the efficacy of BoNT-A versus placebo in a crossover study on LBP...
November 15, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29138109/mesopontine-neurons-implicated-in-anesthetic-loss-of-consciousness-have-either-ascending-or-descending-axonal-projections-but-not-both
#4
Adi Miriam Goldenberg, Anne Minert, Yelena Fishman, Gilly Wolf, Marshall Devor
The MPTA (mesopontine tegmental anesthesia area) is a key node in a network of axonal pathways that collectively engage the key components of general anesthesia: immobility and atonia, analgesia, amnesia and loss-of-consciousness. In this study we have applied double retrograde tracing to analyze MPTA connectivity, with a focus on axon collateralization. Prior tracer studies have shown that collectively, MPTA neurons send descending projections to spinal and medullary brain targets associated with atonia and analgesia as well as ascending projections to forebrain structures associated with amnesia and arousal...
November 11, 2017: Neuroscience
https://www.readbyqxmd.com/read/29134178/wheelchair-services-and-use-outcomes-a-cross-sectional-survey-in-kenya-and-the-philippines
#5
Eva S Bazant, Elizabeth J Himelfarb Hurwitz, Brenda N Onguti, Emma K Williams, Jamie H Noon, Cheryl A Xavier, Ferdiliza D S Garcia, Anthony Gichangi, Mohammed Gabbow, Peter Musakhi, R Lee Kirby
Background: The World Health Organisation recommends that services accompany wheelchair distribution. This study examined the relationship of wheelchair service provision in Kenya and the Philippines and wheelchair-use-related outcomes. Method: We surveyed 852 adult basic manual wheelchair users. Participants who had received services and those who had not were sought in equal numbers from wheelchair-distribution entities. Outcomes assessed were daily wheelchair use, falls, unassisted outdoor use and performance of activities of daily living (ADL)...
2017: Afr J Disabil
https://www.readbyqxmd.com/read/29133075/spinal-cord-self-repair-during-tail-regeneration-in-polypedates-maculatus-and-putative-role-of-fgf1-as-a-neurotrophic-factor
#6
Jutshina Hota, Sushri Sangita Pati, Pravati Kumari Mahapatra
Spinal cord injury could be fatal in man and often results in irreversible medical conditions affecting mobility. However, anuran amphibians win over such pathological condition by the virtue of regeneration abilities. The tail of anuran tadpoles therefore allures researchers to study spinal cord injury and self- repair process. In the present study, we inflicted injury to the spinal cord by means of surgical transection of the tail and investigated the self-repair activity in the tadpoles of the Indian tree frog Polypedates maculatus...
November 10, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29129380/evaluation-of-activities-of-daily-living-in-patients-with-slowly-progressive-neuromuscular-diseases
#7
Katarzyna Bienias, Joanna Ścibek, Joanna Cegielska, Jan Kochanowski
Slowly progressive neuromuscular diseases include but are not limited to: facioscapulohumeral muscular dystrophy (FSHD) and limb-girdle muscular dystrophy (LGMD), hereditary motor and sensory neuropathy (HMSN) and spinal muscular atrophy type III (SMA3). The purpose of this study is to present an evaluation of basic and complex activities of daily living in patients suffering from these diseases. The study was conducted on a group of 58 Polish patients: 25 patients with HMSN, 19 with LGMD and FSHD and 14 with SMA3...
October 27, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29127599/cb1-receptors-mediated-inhibition-of-atp-induced-ca-2-i-increase-in-cultured-rat-spinal-dorsal-horn-neurons
#8
Jingdong Long, Xiaolu Lei, Meiyun Chen, Shulei Yang, Tao Sun, Junwei Zeng, Deqian Yu, Hong Tian, Xiaohong Liu
Spinal cannabinoid receptor 1 (CB1R) and purinergic P2X receptors (P2XR) play a critical role in the process of pathological pain. Both CB1R and P2XR are expressed in spinal dorsal horn (DH) neurons. It is not clear whether CB1 receptor activation modulates the function of P2X receptor channels within dorsal horn. For this reason, we observed the effect of CP55940 (cannabinoid receptor agonist) on ATP-induced Ca(2+) mobilization in cultured rat DH neurons. The changes of intracellular calcium concentration ([Ca(2+)]i) were detected with confocal laser scanning microscopy using fluo-4/AM as a calcium fluorescent indicator...
November 10, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/29115575/microrna-142-3p-relieves-neuropathic-pain-by-targeting-high-mobility-group-box-1
#9
Yang Zhang, Junying Mou, Li Cao, Su Zhen, Hongjuan Huang, Hongguang Bao
MicroRNA (miRNA) are emerging as critical regulators of neuropathic pain development. Neuroinflammation contributes to the development of neuropathic pain. miR‑142‑3p has been characterized as an inflammation‑related miRNA in various pathological processes. However, little is known about the role of miR‑142‑3p in neuroinflammation and neuropathic pain. The present study aimed to investigate the function of miR‑142‑3p in neuropathic pain by creating a murine model using spinal nerve ligation (SNL)...
October 27, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29113764/effect-of-two-level-pedicle-screw-fixation-with-different-rod-materials-on-lumbar-spine-a-finite-element-study
#10
Jayanta Kumar Biswas, Masud Rana, Santanu Majumder, Santanu Kumar Karmakar, Amit Roychowdhury
BACKGROUND: Pedicle-screw-rod fixation system is very popular surgical remedy for degenerative disc disease. It is important to observe load vs. spinal motion characteristic for better understanding of clinical problems and treatment of spinal instability associated with low-back pain. OBJECTIVE: The objective of this study is to understand the effect [range of motion (ROM) and intervertebral foramen height] of pedicle-screw fixation with three rod materials on lumbar spine under three physiological loading conditions...
November 4, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29105225/is-the-self-reporting-of-failed-back-surgery-syndrome-patients-treated-with-spinal-cord-stimulation-in-line-with-objective-measurements
#11
Lisa Goudman, Iris Smet, Peter Mariën, Mats De Jaeger, Sander De Groote, Eva Huysmans, Koen Putman, Jean-Pierre Van Buyten, Ronald Buyl, Maarten Moens
OBJECTIVES: To understand the subjective pain experience of patients, healthcare providers rely heavily on self-reporting. However, to quantify this unique pain experience, objective parameters are not yet available in daily clinical practice. With regard to patients with failed back surgery syndrome (FBSS) treated with spinal cord stimulation (SCS), pain therapists may recover the individual functional information about the patient's posture from the implantable pulse generator (IPG) of the stimulator...
November 3, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29097953/a-young-female-athlete-with-acute-low-back-pain-caused-by-stage-iv-breast-cancer
#12
Evan A Kahn
Objective: The purpose of this case report is to describe the case of a young female athlete with low back pain caused by metastatic breast cancer. Clinical Features: A 27-year-old woman presented with low back pain after striking a ball during kickball 3 days earlier. Because of the mechanism of injury and onset, the patient was originally diagnosed with a lumbar spine sprain/strain. Intervention/Outcome: After radiographs were obtained and were read as unremarkable, a 2-week trial of care was initiated that included soft-tissue mobilizations, anti-inflammatory medications from her primary care physician, and therapeutic rehabilitation exercises...
September 2017: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/29081392/hybrid-assistive-limb-exoskeleton-hal%C3%A2-in-the-rehabilitation-of-chronic-sci-proof-of-concept-the-results-of-21-patients
#13
Oliver Jansen, Dennis Grasmuecke, Renate C Meindl, Martin Tegenthoff, Peter Schwenkreis, Matthias Sczesny-Kaiser, Martin Wessling, Thomas A Schildhauer, Christian Fisahn, Mirko Aach
INTRODUCTION: The use of mobile exoskeletons is becoming more and more common in the field of spinal cord injury rehabilitation. The hybrid assistive limb exoskeleton (HAL) provides a tailored support depending on the patient's voluntary drive. MATERIALS AND METHODS: After a pilot study which included 8 chronic SCI patients (2014), this study of 21 chronic SCI patients serves as a proof of concept. It was conducted to provide further evidence regarding the efficacy of exoskeletal-based rehabilitation...
October 25, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29071122/diagnostic-algorithm-prognostic-factors-and-surgical-treatment-of-metastatic-cancer-diseases-of-the-long-bones-and-spine
#14
REVIEW
Miklós Szendrői, Imre Antal, Attila Szendrői, Áron Lazáry, Péter Pál Varga
Oncological management of skeletal metastases has changed dramatically in the last few decades. A significant number of patients survive for many years with their metastases.Surgeons are more active and the technical repertoire is broader, from plates to intramedullary devices to (tumour) endoprostheses.The philosophy of treatment should be different in the case of a trauma-related fracture and a pathological fracture. A proper algorithm for establishing a diagnosis and evaluation of prognostic factors helps in planning the surgical intervention...
September 2017: EFORT open reviews
https://www.readbyqxmd.com/read/29068039/respiratory-cardiovascular-and-metabolic-responses-during-different-modes-of-overground-bionic-ambulation-in-persons-with-motor-incomplete-spinal-cord-injury-a-case-series
#15
Jochen Kressler, Tracie Wymer, Antoinette Domingo
OBJECTIVE: To investigate the effects of overground bionic ambulation with variable assistance on cardiorespiratory and metabolic responses in persons with motor-incomplete spinal cord injury. DESIGN: Case series. SUBJECTS: Four participants with chronic, motor-incomplete spinal cord injury. METHODS: Subjects completed a maximal graded exercise test on an arm-ergometer and 3 6-min bouts of overground bionic ambulation using different modes of assistance, i...
October 25, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29066098/brown-s%C3%A3-quard-syndrome-and-cervical-post-traumatic-subarachnoid-hematoma
#16
Fernando Rascón-Ramírez, Josué M Avecillas-Chasín, Albert Trondin, M Javier Arredondo
Cervical Traumatic SSH are very rare in literature. They are usually caused by cardiopulmonary diseases that increase vascular pressure causing spinal vessels rupture. In thoracolumbar spine, the spinal puncture is the most common cause. The ventrolateral position is even more unusual. In traumatic brain injury (TBI), an abrupt extension-flexion movement could have caused the rupture of subarachnoid vessels. This, accompanied by the slowed blood "wash out" (probably due to the previous osteoarthrosis and spinal canal stenosis), led to the formation of an organized clot, which caused an acute spinal cord compression syndrome...
October 20, 2017: Neurocirugía
https://www.readbyqxmd.com/read/29065931/relevance-of-structural-damage-in-the-sacroiliac-joints-for-the-functional-status-and-spinal-mobility-in-patients-with-axial-spondyloarthritis-results-from-the-german-spondyloarthritis-inception-cohort
#17
Mikhail Protopopov, Joachim Sieper, Hildrun Haibel, Joachim Listing, Martin Rudwaleit, Denis Poddubnyy
BACKGROUND: Functional status and spinal mobility in patients with axial spondyloarthritis (axSpA) are known to be determined both by disease activity and by structural damage in the spine. The impact of structural damage in the sacroiliac joints (SIJ) on physical function and spinal mobility in axSpA has not been studied so far. The objective of the study was to analyze the impact of radiographic sacroiliitis on functional status and spinal mobility in patients with axSpA. METHODS: In total, 210 patients with axSpA were included in the analysis...
October 24, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29065645/effect-of-graded-facetectomy-on-lumbar-biomechanics
#18
Zhi-Li Zeng, Rui Zhu, Yang-Chun Wu, Wei Zuo, Yan Yu, Jian-Jie Wang, Li-Ming Cheng
Facetectomy is an important intervention for spinal stenosis but may lead to spinal instability. Biomechanical knowledge for facetectomy can be beneficial when deciding whether fusion is necessary. Therefore, the aim of this study was to investigate the biomechanical effect of different grades of facetectomy. A three-dimensional nonlinear finite element model of L3-L5 was constructed. The mobility of the model and the intradiscal pressure (IDP) of L4-L5 for standing were inside the data from the literature...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29061187/elevated-microrna-129-5p-level-ameliorates-neuroinflammation-and-blood-spinal-cord-barrier-damage-after-ischemia-reperfusion-by-inhibiting-hmgb1-and-the-tlr3-cytokine-pathway
#19
Xiao-Qian Li, Feng-Shou Chen, Wen-Fei Tan, Bo Fang, Zai-Li Zhang, Hong Ma
BACKGROUND: Ischemia-reperfusion (IR) affects microRNA (miR) expression and causes substantial inflammation. Multiple roles of the tumor suppressor miR-129-5p in cerebral IR have recently been reported, but its functions in the spinal cord are unclear. Here, we investigated the role of miR-129-5p after spinal cord IR, particularly in regulating high-mobility group box-1 (HMGB1) and the Toll-like receptor (TLR)-3 pathway. METHODS: Ischemia was induced via 5-min occlusion of the aortic arch...
October 23, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29057989/physical-therapy-is-targeted-and-adjusted-over-time-for-the-rehabilitation-of-locomotor-function-in-acute-spinal-cord-injury-interventions-in-physical-and-sports-therapy
#20
Martina Franz, Lea Richner, Markus Wirz, Anne von Reumont, Ulla Bergner, Tanja Herzog, Werner Popp, Kathrin Bach, Norbert Weidner, Armin Curt
STUDY DESIGN: Prospective observational multicenter study. OBJECTIVES: Investigation of content, duration and adjustment of physical therapy for the rehabilitation of ambulation in acute spinal cord injury (SCI). SETTING: European Multicenter Study of SCI (EMSCI). METHODS: Physical therapy interventions during acute in-patient rehabilitation of eighty incomplete SCI patients (AIS B, C, D all lesion levels) were recorded using the SCI - Intervention Classification System...
October 23, 2017: Spinal Cord
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