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https://www.readbyqxmd.com/read/28931212/temozolomide-resistant-human-brain-tumor-stem-cells-are-susceptible-to-recombinant-vesicular-stomatitis-virus-and-double-deleted-vaccinia-virus-in-vitro
#1
Bin Jiang, Xueqing Lun, Xiaoguang Hao, Yihua Wang, Xin Yin, Dezhang Huang, Wei He, Zhigang Wang
BACKGROUND: Malignant glioma still has a poor prognosis and remains incurable. Although temozolomide (TMZ) has demonstrated antitumor activity, its use recently has been halted because of some patients' resistance to this drug. New treatments are desperately needed. An oncolytic virus (virotherapy) is being developed as a novel cancer therapy. We have previously reported that recombinant Vesicular Stomatitis Virus (VSV-ΔM51) and double deleted Vaccinia Virus (vvDD) infected and killed glioma cell lines in vitro and prolonged survival in animal glioma models...
September 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28931096/-nutrition-therapy-of-cancer-patients
#2
József Lövey
The majority of cancer patients becomes malnourished during the course of their disease. Malnutrition deteriorates the efficiency of all kinds of oncologic interventions. As a consequence of it, treatment-related toxicity increases, hospital stay is lengthened, chances of cure and survival as well as the quality of life of the patients worsen. Nutritional status therefore influences all aspects of outcome of oncology care. In spite of this the use of nutritional therapy varies across health care providers but its application is far from being sufficient during active oncology interventions as well as rehabilitation and supportive care...
September 20, 2017: Magyar Onkologia
https://www.readbyqxmd.com/read/28931095/-new-recommendations-in-oncocardiology
#3
Csaba András Nagy, Mária Lódi, Ingrid Balogh, Dániel Czuriga, Judit Kocsis
It is well-known that modern oncotherapy significantly reduced the mortality of malignant diseases. However, serious side effects of the applied cancer therapies have evolved, which may adversely affect the cardiovascular system. Early side effects often limit therapeutic success of oncotherapy and may require treatment interruption, while late-onset side effects can adversely influence the long-term survival of patients recovering from cancer. Oncocardiology is a new medical field gaining more and more attention...
September 20, 2017: Magyar Onkologia
https://www.readbyqxmd.com/read/28931080/low-serum-level-of-mir-485-3p-predicts-poor-survival-in-patients-with-glioblastoma
#4
Zhi-Qiang Wang, Mei-Yin Zhang, Mei-Ling Deng, Nuo-Qing Weng, Hui-Yun Wang, Shao-Xiong Wu
MicroRNAs (miRNAs) are short noncoding RNAs that play critical roles in human malignancies and can be used as biomarkers for cancer. Until now, a number of biomarkers for prognosis of glioblastoma (GBM) have been reported in tumor tissues but only a few biomarkers in circulating fluid. Using a custom microarray, we previously identified 19 differentially expressed miRNAs in serum of patients with GBM. In this study, we investigated whether 3 of the 19 miRNAs in serum could be used as prognostic biomarkers for patients with GBM...
2017: PloS One
https://www.readbyqxmd.com/read/28931069/methylation-associated-transcriptional-repression-of-elovl5-in-novel-colorectal-cancer-cell-lines
#5
Arnoud Boot, Jan Oosting, Jaap D H van Eendenburg, Peter J K Kuppen, Hans Morreau, Tom van Wezel
Genetic and epigenetic alterations mark colorectal cancer (CRC). Global hypomethylation is observed in nearly all CRC, but a distinct subset of CRC show the CpG Island Methylator Phenotype (CIMP). These tumors show DNA hypermethylation of a specific subset of CpG islands, resulting in transcriptional downregulation of nearby genes. Recently we reported the establishment of novel CRC cell lines derived from primary and metastatic CRC tissues. In this study we describe the DNA methylation profiling of these low passage CRC cell lines...
2017: PloS One
https://www.readbyqxmd.com/read/28931068/erk1-2-signalling-protects-against-apoptosis-following-endoplasmic-reticulum-stress-but-cannot-provide-long-term-protection-against-bax-bak-independent-cell-death
#6
Nicola J Darling, Kathryn Balmanno, Simon J Cook
Disruption of protein folding in the endoplasmic reticulum (ER) causes ER stress. Activation of the unfolded protein response (UPR) acts to restore protein homeostasis or, if ER stress is severe or persistent, drive apoptosis, which is thought to proceed through the cell intrinsic, mitochondrial pathway. Indeed, cells that lack the key executioner proteins BAX and BAK are protected from ER stress-induced apoptosis. Here we show that chronic ER stress causes the progressive inhibition of the extracellular signal-regulated kinase (ERK1/2) signalling pathway...
2017: PloS One
https://www.readbyqxmd.com/read/28931051/interleukin-17-positive-mast-cells-influence-outcomes-from-bcg-for-patients-with-cis-data-from-a-comprehensive-characterisation-of-the-immune-microenvironment-of-urothelial-bladder-cancer
#7
Alexander C Dowell, Ellen Cobby, Kaisheng Wen, Adam J Devall, Vinnie During, Jane Anderson, Nicholas D James, Kar K Cheng, Maurice P Zeegers, Richard T Bryan, Graham S Taylor
The tumour immune microenvironment is considered to influence cancer behaviour and outcome. Using a panel of markers for innate and adaptive immune cells we set out to characterise and understand the bladder tumour microenvironment of 114 patients from a prospective multicentre cohort of newly-diagnosed bladder cancer patients, followed-up for 4.33±1.71 years. We found IL-17-positive cells were significantly increased in primary and concomitant carcinoma in situ (CIS), p<0.0001, a highly malignant lesion which is the most significant single risk factor for disease progression...
2017: PloS One
https://www.readbyqxmd.com/read/28931042/evaluation-of-the-cytotoxicity-of-the-bithionol-paclitaxel-combination-in-a-panel-of-human-ovarian-cancer-cell-lines
#8
Vijayalakshmi N Ayyagari, Paula L Diaz-Sylvester, Tsung-Han Jeff Hsieh, Laurent Brard
Previously, Bithionol (BT) was shown to enhance the chemosensitivity of ovarian cancer cell lines to cisplatin treatment. In the present study, we focused on the anti-tumor potential of the BT-paclitaxel combination when added to a panel of ovarian cancer cell lines. This in vitro study aimed to 1) determine the optimum schedule for combination of BT and paclitaxel and 2) assess the nature and mechanism(s) underlying BT-paclitaxel interactions. The cytotoxic effects of both drugs either alone or in combination were assessed by presto-blue cell viability assay using six human ovarian cancer cell lines...
2017: PloS One
https://www.readbyqxmd.com/read/28931010/response-to-folfirinox-by-gender-in-patients-with-metastatic-pancreatic-cancer-results-from-the-prodige-4-accord-11-randomized-trial
#9
Aurélien Lambert, Marta Jarlier, Sophie Gourgou Bourgade, Thierry Conroy
BACKGROUND: Hohla et al. suggested that female gender could positively predict response to FOLFIRINOX in patients with advanced pancreatic cancer. In this study, we explored the response to the FOLFIRINOX regimen by gender within the trial PRODIGE4/ACCORD 11. PATIENTS AND METHODS: Data were described by gender, both in FOLFIRINOX group and in the intention-to-treat population of the trial. The relative effect of gender (females in comparison to males) on overall survival (OS) and progression-free survival was estimated by using a Cox proportional hazard model and was presented with the Hazard Ratio and their 95% confidence interval...
2017: PloS One
https://www.readbyqxmd.com/read/28930829/the-curative-effects-of-radiotherapy-based-therapies-for-human-epidermal-growth-factor-receptor-2-positive-breast-cancer-a-meta-analysis
#10
Minghai Shao, Chi Zhang, Qin Qin, Zhaoyue Zhang, Hongcheng Zhu, Xiaoke Di, Xinchen Sun
AIM: This meta-analysis was designed to fully assess the curative effects of radiotherapy-based therapies for human epidermal growth factor receptor 2-positive (HER2+) breast cancer (BC). METHODS: English articles were retrieved through searching Cochrane library, PubMed, and Embase databases updated to February 2017. Studies were selected based on the inclusion and exclusion criteria. The curative effects of radiotherapy-based therapies forHER2+ BC patients were assessed using hazard rates (HRs) or odds ratios (ORs), as well as their 95% confidence intervals (CIs)...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28930810/oncological-outcomes-of-stage-ii-endometrial-cancer-a-retrospective-analysis-of-250-cases
#11
Nejat Ozgul, Gokhan Boyraz, Mehmet Coskun Salman, Murat Gultekin, Kunter Yuce, Akbar Ibrahimov, Anil Erturk, Kemal Gungorduk, Varol Gulseren, Muzaffer Sanci, Osman Turkmen, Alper Karalok, Gunsu Kimyon, Taner Turan, Nazli Topfedaisi Ozkan, Mehmet Mutlu Meydanli, Tayfun Gungor, Hulya Ayik, Tayup Simsek
OBJECTIVE: The aim of this study was to investigate the effect of different surgical approaches, adjuvant therapy, and pathological characteristics on oncological outcomes in patients with 2009 International Federation of Gynecology and Obstetrics (FIGO) stage II endometrial cancer (EC). METHODS: A multicenter, retrospective department database review was performed to identify patients with FIGO 2009 stage II EC who underwent surgical staging between 2002 and 2015 at 5 gynecologic oncology centers in Turkey...
September 19, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28930809/survival-benefit-of-adjuvant-radiotherapy-an-analysis-of-low-stage-invasive-ovarian-mucinous-carcinomas
#12
Aalok Kumar, Nhu Le, C Blake Gilks, Jennifer L Santos, Frances Wong, Kenneth Swenerton, Paul J Hoskins, Jessica N McAlpine, Anna V Tinker
OBJECTIVE: Our aim was to evaluate the population-based outcomes of stages I and II invasive ovarian mucinous carcinomas (MCs) treated with adjuvant platinum-based chemotherapy and abdominopelvic radiotherapy (XRT). METHODS: International Federation of Gynecology and Obstetrics stage I/II MC cases referred to the British Columbia Cancer Agency between 1984 and 2014 were reviewed. Chemotherapy (minimum of 3 cycles) and XRT were the institutional policy for stages IA/B (grade 2/3) and IC/II (any grade)...
September 19, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28930808/the-influence-of-adverse-effects-on-quality-of-life-of-survivors-of-gynecologic-cancer
#13
Chiaki Omichi, Keiichiro Nakamura, Junko Haraga, Naoyuki Ida, Masayuki Saijo, Takeshi Nishida, Tomoyuki Kusumoto, Hisashi Masuyama
OBJECTIVE: The objective of this observational study was to investigate correlations between adverse effects (lower-extremity lymphedema [LEL], dysuria, and severe gastrointestinal symptoms) and quality of life (QOL) (physical well-being [PWB], social well-being, emotional well-being [EWB], and functional well-being) before treatment, at least 6 weeks after treatment (posttreatment1), and 3 or 6 months after treatment (posttreatment2) of patients with gynecologic cancer (GC). METHODS: From August 2012 to October 2016, questionnaire responses and clinical data of 75 patients with GC were collected and assessed by treatment received...
September 19, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28930803/safety-of-fertility-sparing-surgery-for-premenopausal-women-with-sex-cord-stromal-tumors-confined-to-the-ovary
#14
Dimitrios Nasioudis, Melissa K Frey, Eloise Chapman-Davis, Steven S Witkin, Kevin Holcomb
OBJECTIVE: The aim of this retrospective population-based study was to investigate the oncologic safety of fertility-sparing surgery (FSS) for premenopausal women with malignant sex cord-stromal tumors (SCSTs) confined to the ovary. METHODS: A cohort of women aged 18 to 49 years and diagnosed with a stage I malignant SCST between 1984 and 2013 was drawn from the National Cancer Institute's Surveillance, Epidemiology, and End Results database. Based on site-specific surgery codes, women who had FSS, defined as unilateral oophorectomy/tumor resection without hysterectomy, and definite surgery were identified...
September 19, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28930775/phase-i-ii-study-of-s-1-plus-cisplatin-alternating-with-s-1-plus-docetaxel-in-patients-with-advanced-gastric-cancer
#15
Ayumu Hosokawa, Takayuki Ando, Kohei Ogawa, Akira Ueda, Hiroki Yoshita, Hiroshi Mihara, Haruka Fujinami, Shinya Kajiura, Kazuhisa Yabushita, Naoki Horikawa, Yuka Kobayashi, Akira Yoshioka, Hideki Origasa, Toshiro Sugiyama
OBJECTIVES: To investigate the usefulness of S-1 plus cisplatin alternating with S-1 plus docetaxel as first-line treatment in patients with advanced gastric cancer, we conducted a phase I/II study to determine the maximum tolerated dose and recommended dose, and evaluate efficacy and toxicity. MATERIALS AND METHODS: Patients with histologically confirmed unresectable and recurrent gastric cancer were enrolled in this study. Cisplatin was administered on day 1 and the dose escalated by 10 mg/m from a starting dose of 40 mg/m in the phase I part...
September 19, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28930757/high-expression-of-ccr7-predicts-lymph-node-metastasis-and-good-prognosis-in-triple-negative-breast-cancer
#16
Xuelu Li, Siwen Sun, Ning Li, Jiyue Gao, Jing Yu, Jinbo Zhao, Man Li, Zuowei Zhao
BACKGROUND/AIMS: Previous preclinical and clinical studies have reported a positive correlation between the expression of the C-C chemokine receptor 7 (CCR7) and the incidence of lymph node metastasis in breast cancer. However, the prognostic relevance of CCR7 expression in breast cancer remains contradictory till now. The aim of this study is to assess the correlation of the CCR7 expression with other clinicopathological features and prognosis in breast cancer. METHODS: The CCR7 gene amplification and mRNA expression levels from approximately 3,000 patients were retrieved from human breast cancer databases and analyzed...
September 20, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28930749/efficacy-and-safety-of-capecitabine-irinotecan-gemcitabine-and-bevacizumab-as-second-line-treatment-in-advanced-biliary-tract-cancer-a-phase-ii-study
#17
Finn Ole Larsen, Alice Markussen, Laura V Diness, Dorte Nielsen
OBJECTIVE: Since 2010, gemcitabine and cisplatin have been considered standard first-line treatment in patients with advanced biliary tract cancer. Many centers have replaced cisplatin with oxaliplatin, which seems to obtain similar results. While first-line treatment has been well established, there are no phase III trials supporting second-line treatment, and the phase II trials with chemotherapy do not show any clear benefit. In this study, we investigated the effect of adding bevacizumab to chemotherapy in second-line treatment...
September 21, 2017: Oncology
https://www.readbyqxmd.com/read/28930698/2d-and-3d-ct-radiomics-features-prognostic-performance-comparison-in-non-small-cell-lung-cancer
#18
Chen Shen, Zhenyu Liu, Min Guan, Jiangdian Song, Yucheng Lian, Shuo Wang, Zhenchao Tang, Di Dong, Lingfei Kong, Meiyun Wang, Dapeng Shi, Jie Tian
OBJECTIVE: To compare 2D and 3D radiomics features prognostic performance differences in CT images of non-small cell lung cancer (NSCLC). METHOD: We enrolled 588 NSCLC patients from three independent cohorts. Two sets of 463 patients from two different institutes were used as the training cohort. The remaining cohort with 125 patients was set as the validation cohort. A total of 1014 radiomics features (507 2D features and 507 3D features correspondingly) were assessed...
September 17, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28930697/overexpression-of-muc1-and-genomic-alterations-in-its-network-associate-with-prostate-cancer-progression
#19
Xiaozeng Lin, Yan Gu, Anil Kapoor, Fengxiang Wei, Tariq Aziz, Diane Ojo, Yanzhi Jiang, Michael Bonert, Bobby Shayegan, Huixiang Yang, Khalid Al-Nedawi, Pierre Major, Damu Tang
We investigate the association of MUC1 with castration-resistant prostate cancer (CRPC), bone metastasis, and PC recurrence. MUC1 expression was studied in patient-derived bone metastasis and CRPCs produced by prostate-specific PTEN(-/-) mice and LNCaP xenografts. Elevations in MUC1 expression occur in CRPC. Among nine patients with hormone-naïve bone metastasis, eight express MUC1 in 61% to 100% of PC cells. Utilizing cBioPortal PC genomic data, we organized a training (n=300), testing (n=185), and validation (n=194) cohort...
September 17, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28930692/palbociclib-in-hormone-receptor-positive-advanced-breast-cancer-a-cost-utility-analysis
#20
J Raphael, J Helou, K I Pritchard, D M Naimark
INTRODUCTION: The addition of palbociclib to letrozole improves progression-free survival in the first-line treatment of hormone receptor positive advanced breast cancer (ABC). This study assesses the cost-utility of palbociclib from the Canadian healthcare payer perspective. METHODS: A probabilistic discrete event simulation (DES) model was developed and parameterised with data from the PALOMA 1 and 2 trials and other sources. The incremental cost per quality-adjusted life-month (QALM) gained for palbociclib was calculated...
September 17, 2017: European Journal of Cancer
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