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Prostate Cancer Screening Test

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https://www.readbyqxmd.com/read/29790951/internet-use-and-preventive-health-behaviors-among-couples-in-later-life-evidence-from-the-health-and-retirement-study
#1
Sangbo Nam, Sae Hwang Han, Megan Gilligan
Background and Objectives: The aim of this study was to examine the link between internet use and preventive health behaviors. We focused on couples to examine whether there were cross-partner associations between internet use and preventive health behaviors. Research Design and Methods: The data for this study came from the 2010 and 2012 waves of the Health and Retirement Study and the sample consisted of 5,143 pairs of coupled-individuals. Preventive health behaviors included cancer screenings (mammogram and prostate tests), cholesterol tests, and flu shots...
May 22, 2018: Gerontologist
https://www.readbyqxmd.com/read/29789573/high-throughput-screening-of-prostate-cancer-risk-loci-by-single-nucleotide-polymorphisms-sequencing
#2
Peng Zhang, Ji-Han Xia, Jing Zhu, Ping Gao, Yi-Jun Tian, Meijun Du, Yong-Chen Guo, Sufyan Suleman, Qin Zhang, Manish Kohli, Lori S Tillmans, Stephen N Thibodeau, Amy J French, James R Cerhan, Li-Dong Wang, Gong-Hong Wei, Liang Wang
Functional characterization of disease-causing variants at risk loci has been a significant challenge. Here we report a high-throughput single-nucleotide polymorphisms sequencing (SNPs-seq) technology to simultaneously screen hundreds to thousands of SNPs for their allele-dependent protein-binding differences. This technology takes advantage of higher retention rate of protein-bound DNA oligos in protein purification column to quantitatively sequence these SNP-containing oligos. We apply this technology to test prostate cancer-risk loci and observe differential allelic protein binding in a significant number of selected SNPs...
May 22, 2018: Nature Communications
https://www.readbyqxmd.com/read/29788475/associations-between-prediagnostic-concentrations-of-circulating-sex-steroid-hormones-and-esophageal-gastric-cardia-adenocarcinoma-among-men
#3
Jessica L Petrick, Paula L Hyland, Patrick Caron, Roni T Falk, Ruth M Pfeiffer, Sanford M Dawsey, Christian C Abnet, Philip R Taylor, Stephanie J Weinstein, Demetrius Albanes, Neal D Freedman, Susan M Gapstur, Gary Bradwin, Chantal Guillemette, Peter T Campbell, Michael B Cook
Background: Esophageal adenocarcinoma (EA) and gastric cardia adenocarcinoma (GCA) are characterized by a strong male predominance. Concentrations of sex steroid hormones have been hypothesized to explain this sex disparity. However, no prospective population-based study has examined sex steroid hormones in relation to EA/GCA risk. Thus, we investigated whether prediagnostic circulating sex steroid hormone concentrations were associated with EA/GCA in a nested case-control study drawn from participants in three prospective cohort studies...
May 17, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29786851/annual-report-to-the-nation-on-the-status-of-cancer-part-ii-recent-changes-in-prostate-cancer-trends-and-disease-characteristics
#4
Serban Negoita, Eric J Feuer, Angela Mariotto, Kathleen A Cronin, Valentina I Petkov, Sarah K Hussey, Vicki Benard, S Jane Henley, Robert N Anderson, Stacey Fedewa, Recinda L Sherman, Betsy A Kohler, Barbara J Dearmon, Andrew J Lake, Jiemin Ma, Lisa C Richardson, Ahmedin Jemal, Lynne Penberthy
BACKGROUND: Temporal trends in prostate cancer incidence and death rates have been attributed to changing patterns of screening and improved treatment (mortality only), among other factors. This study evaluated contemporary national-level trends and their relations with prostate-specific antigen (PSA) testing prevalence and explored trends in incidence according to disease characteristics with stage-specific, delay-adjusted rates. METHODS: Joinpoint regression was used to examine changes in delay-adjusted prostate cancer incidence rates from population-based US cancer registries from 2000 to 2014 by age categories, race, and disease characteristics, including stage, PSA, Gleason score, and clinical extension...
May 22, 2018: Cancer
https://www.readbyqxmd.com/read/29784740/nccn-guidelines-updates-prostate-cancer-and-prostate-cancer-early-detection
#5
Peter H Carroll, James L Mohler
Peter H. Carroll, MD, MPH, and James L. Mohler, MD, updated attendees on what is new in the 2018 NCCN Guidelines for Prostate Cancer Early Detection and for Prostate Cancer, respectively. Their presentations touched on new screening recommendations, shared decision-making, risk stratification, the role of genomic and molecular testing, active surveillance, and newer systemic treatments.
May 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29781117/psa-screening-prostate-biopsy-and-treatment-of-prostate-cancer-in-the-years-surrounding-the-uspstf-recommendation-against-prostate-cancer-screening
#6
James T Kearns, Sarah K Holt, Jonathan L Wright, Daniel W Lin, Paul H Lange, John L Gore
BACKGROUND: The 2012 United States Preventive Services Task Force recommendation against screening for prostate cancer has impacted rates of prostate-specific antigen (PSA) screening and appears to be associated with declining prostate cancer incidence. Our objective was to characterize health care utilization that may explain these observed trends. METHODS: MarketScan claims, which capture >30 million privately insured patients in the United States, were queried for all men aged 40-64 years for the years 2008-2014...
May 21, 2018: Cancer
https://www.readbyqxmd.com/read/29779368/automated-3d-printed-microfluidic-array-for-rapid-nanomaterial-enhanced-detection-of-multiple-proteins
#7
Karteek Kadimisetty, Spundana Malla, Ketki Bhalerao, Islam M Mosa, Snehasis Bhakta, Norman Lee, James F Rusling
We report here the fabrication and validation of a novel 3D printed, automated immunoarray to detect multiple proteins with ultralow detection limits. This low cost, miniature immunoarray employs electrochemiluminescent (ECL) detection measured with a CCD camera and employs touch screen control of a micropump to facilitate automated use. The miniaturized array features prefilled reservoirs to deliver sample and reagents to a paper-thin pyrolytic graphite microwell detection chip to complete sandwich immunoassays...
May 21, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29772218/new-evidence-for-the-benefit-of-psa-screening-data-from-400-887-kaiser-permanente-patients
#8
Paul F Alpert
OBJECTIVES: To investigate whether prostate cancer screening with PSA is beneficial in reducing prostate cancer mortality, and to determine optimal screening intervals and age groups to be screened. MATERIALS AND METHODS: This is a retrospective cohort study of 400,887 men under age 80, with no prior history of prostate cancer, who had PSA testing at Kaiser Permanente Northern California in the 5 calendar years 1998 to 2002, and were followed for 12-16 years. Subjects were stratified into 6 groups based on the screening interval, and into 7 groups based on age...
May 14, 2018: Urology
https://www.readbyqxmd.com/read/29763267/top-20-research-studies-of-2017-for-primary-care-physicians
#9
Mark H Ebell, Roland Grad
Based on systematic surveillance of more than 110 medical journals, 247 studies met criteria as POEMs (patient-oriented evidence that matters) in 2017. Members of the Canadian Medical Association identified 20 of these POEMs as most relevant to practice. This article reviews the clinical questions and bottom-line answers from these studies. Blood pressure should be measured after a period of rest, using a bare arm, and orthostatic blood pressure is more predictive when measured after one minute of standing rather than three minutes...
May 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29748182/a-pdx-organoid-biobank-of-advanced-prostate-cancers-captures-genomic-and-phenotypic-heterogeneity-for-disease-modeling-and-therapeutic-screening
#10
Michael L Beshiri, Caitlin M Tice, Crystal Tran, Holly M Nguyen, Adam G Sowalsky, Supreet Agarwal, Keith H Jansson, Qi Yang, Kerry A McGowen, Juan Juan Yin, Aian Neil Alilin, Fatima H Karzai, William Dahut, Eva Corey, Kathleen Kelly
PURPOSE: Prostate cancer translational research has been hampered by the lack of comprehensive and tractable models   that represent the genomic landscape of clinical disease. Metastatic castrate-resistant prostate cancer (mCRPC) patient-derived xenografts (PDXs) recapitulate the genetic and phenotypic diversity of the disease. We sought to establish a representative, preclinical platform of PDX-derived organoids that is experimentally facile for high throughput and mechanistic analysis...
May 10, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29744304/insights-for-public-education-provided-by-french-media-on-ideas-about-prostate-cancer-a-media-analysis-study
#11
Margareth S Zanchetta, Marguerite Cognet, Mary Rachel Lam-Kin-Teng, Marie Elisabeth Dumitriu, Carlos Haag, Bernard Kadio, François Desgrandchamps, Lise Rénaud
Background: This study explored the French media's presentation of ideas and medical information about prostate cancer (PC) that may influence men's understanding, attitudes and behavior. Methods: A qualitative media content analysis centered on PC information delivered by French professional media. The selected data were produced in the aftermath of the High Health Authority's decision in 2008 not to recommend systematic screening by prostate specific antigen(PSA) for men over 50. Source was the Media Archives of the French National Library...
2018: Health Promotion Perspectives
https://www.readbyqxmd.com/read/29743218/living-in-cold-spot-communities-is-associated-with-poor-health-and-health-quality
#12
Winston Liaw, Alex H Krist, Sebastian T Tong, Roy Sabo, Camille Hochheimer, Jennifer Rankin, David Grolling, Jene Grandmont, Andrew W Bazemore
PURPOSE: Little is known about incorporating community data into clinical care. This study sought to understand the clinical associations of cold spots (census tracts with worse income, education, and composite deprivation). METHODS: Across 12 practices, we assessed the relationship between cold spots and clinical outcomes (obesity, uncontrolled diabetes, pneumonia vaccination, cancer screening-colon, cervical, and prostate-and aspirin chemoprophylaxis) for 152,962 patients...
May 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29743049/cost-implications-of-psa-screening-differ-by-age
#13
Karthik Rao, Stella Liang, Michael Cardamone, Corinne E Joshu, Kyle Marmen, Nrupen Bhavsar, William G Nelson, H Ballentine Carter, Michael C Albert, Elizabeth A Platz, Craig E Pollack
BACKGROUND: Multiple guidelines seek to alter rates of prostate-specific antigen (PSA)-based prostate cancer screening. The costs borne by payers associated with PSA-based screening for men of different age groups-including the costs of screening and subsequent diagnosis, treatment, and adverse events-remain uncertain. We sought to develop a model of PSA costs that could be used by payers and health care systems to inform cost considerations under a range of different scenarios. METHODS: We determined the prevalence of PSA screening among men aged 50 and higher using 2013-2014 data from a large, multispecialty group, obtained reimbursed costs associated with screening, diagnosis, and treatment from a commercial health plan, and identified transition probabilities for biopsy, diagnosis, treatment, and complications from the literature to generate a cost model...
May 9, 2018: BMC Urology
https://www.readbyqxmd.com/read/29730198/long-term-outcomes-after-deferred-radical-prostatectomy-in-men-initially-managed-by-active-surveillance
#14
Rebecka Arnsrud Godtman, Max Schafferer, Carl-Gustaf Pihl, Johan Stranne, Jonas Hugosson
PURPOSE: To determine the long-term outcomes after deferred radical prostatectomy. MATERIAL AND METHODS: The study population consisted of all men with screening-detected prostate cancer who underwent deferred radical prostatectomy (n=132; 1 Jan 1995-31 Dec 2014) after active surveillance in the Göteborg Randomized, Population-based Prostate Cancer Screening Trial. The last date of follow-up was 15 May 2017. Follow-up during active surveillance was performed with prostate-specific antigen (PSA)-tests every 3-6 months and repeat biopsies every 2-4 years...
May 3, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29718569/grp78-targeted-in-silico-virtual-screening-of-novel-anticancer-agents
#15
Ambily Nath Indu Viswanath, Ji Woong Lim, Seon Hee Seo, Jae Yeol Lee, Sang Min Lim, Ae Nim Pae
Overexpression of GRP78 in a variety of cancers such as glioblastoma, leukaemia, lung, prostate, breast, gastric, and colon makes it a prime target for anticancer drug development. Present study reports GRP78-based design of novel anticancer agents using in silico methods. As a first step towards the work, the interactions between GRP78 and 15 known ligands were modeled by docking simulation. The docked complex, GRP78-13, superior to other compounds with respect to its experimental activity and energy descriptors, was deduced into a structure-based pharmacophore...
May 2, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29713200/the-impact-of-moderate-wine-consumption-on-the-risk-of-developing-prostate-cancer
#16
REVIEW
Mihai Dorin Vartolomei, Shoji Kimura, Matteo Ferro, Beat Foerster, Mohammad Abufaraj, Alberto Briganti, Pierre I Karakiewicz, Shahrokh F Shariat
Objective: To investigate the impact of moderate wine consumption on the risk of prostate cancer (PCa). We focused on the differential effect of moderate consumption of red versus white wine. Design: This study was a meta-analysis that includes data from case-control and cohort studies. Materials and methods: A systematic search of Web of Science, Medline/PubMed, and Cochrane library was performed on December 1, 2017. Studies were deemed eligible if they assessed the risk of PCa due to red, white, or any wine using multivariable logistic regression analysis...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29712628/a-web-based-intervention-to-reduce-distress-after-prostate-cancer-treatment-development-and-feasibility-of-the-getting-down-to-coping-program-in-two-different-clinical-settings
#17
Jane Cockle-Hearne, Deborah Barnett, James Hicks, Mhairi Simpson, Isabel White, Sara Faithfull
BACKGROUND: Distress after prostate cancer treatment is a substantial burden for up to one-third of men diagnosed. Physical and emotional symptoms and health service use can intensify, yet men are reticent to accept support. To provide accessible support that can be cost effectively integrated into care pathways, we developed a unique, Web-based, self-guided, cognitive-behavior program incorporating filmed and interactive peer support. OBJECTIVE: To assess feasibility of the intervention among men experiencing distress after prostate cancer treatment...
April 30, 2018: JMIR Cancer
https://www.readbyqxmd.com/read/29697032/synthesis-17%C3%AE-hydroxylase-c17-20-lyase-inhibitory-and-5ar-reductase-activity-of-novel-pregnenolone-derivatives
#18
Abid H Banday, Shameem A Shameem, Javid A Banday, Bashir A Ganaie
A series of 1,5-diaryl pyrazoline pregnenolones were synthesized and screened for 5α-reductase inhibitory activities. Synthesis of the analogs is multistep and proceeds in good overall yields. The key step in the synthesis of 1,5-disubstituted pyrazolinyl pregnenolones (5a-l) is the heterocyclization of bezylidine derivatives (3) in presence of phenylhydrazines (4) through the initial formation of the phenylhydrazones, which undergo concomitant cyclization to generate the stable pyrazoline derivatives. All compounds were tested for their prostate cancer cell inhibitory, 5α-reductase and 17α-hydroxylase-C17,20-lyase inhibitory activities...
April 25, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29696211/characteristics-of-cancer-patients-participating-in-presurgical-lifestyle-intervention-trials-exploring-effects-on-tumor-biology
#19
John A Dasher, Andrew D Frugé, Denise C Snyder, Wendy Demark-Wahnefried
Background: Poor diet and insufficient physical activity are strongly associated with an increased risk of several cancers. Preclinical studies suggest that lifestyle modifications may exert favorable effects on tumor biology. Randomized controlled trials in the presurgical setting serve as an ideal means to translate this research to humans; however, little is known about the characteristics of patients who enroll in these presurgical trials versus those who do not. Methods: Screening databases from three presurgical lifestyle intervention trials for breast and prostate cancer patients conducted at Duke University Medical Center (NCT00049309) and the University of Alabama at Birmingham (NCT02224807 and NCT01886677) were combined for analysis...
December 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29682740/implications-of-false-positive-results-for-future-cancer-screenings
#20
Glen B Taksler, Nancy L Keating, Michael B Rothberg
BACKGROUND: False-positive cancer screening results may affect a patient's willingness to obtain future screening. METHODS: The authors conducted logistic regression analysis of 450,484 person-years of electronic medical records (2006-2015) in 92,405 individuals aged 50 to 75 years. Exposures were false-positive breast, prostate, or colorectal cancer screening test results (repeat breast imaging or negative breast biopsy ≤3 months after screening mammography, repeat prostate-specific antigen [PSA] test ≤3 months after PSA test result ≥4...
April 23, 2018: Cancer
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