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Prostate Cancer Screening Test

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https://www.readbyqxmd.com/read/28220802/the-prostate-cancer-prevention-trial-risk-calculator-2-0-performs-equally-for-standard-biopsy-and-mri-us-fusion-guided-biopsy
#1
M Maruf, M Fascelli, A K George, M M Siddiqui, M Kongnyuy, J M DiBianco, A Muthigi, S Valayil, A Sidana, T P Frye, A Kilchevsky, P L Choyke, B Turkbey, B J Wood, P A Pinto
BACKGROUND: The Prostate Cancer Prevention Trial Risk Calculator 2.0 (PCPTRC) is a widely used risk-based calculator used to assess a man's risk of prostate cancer (PCa) before biopsy. This risk calculator was created from data of a patient cohort undergoing a 6-core sextant biopsy, and subsequently validated in men undergoing 12-core systematic biopsy (SBx). The accuracy of the PCPTRC has not been studied in patients undergoing magnetic resonance imaging/ultrasound (MRI/US) fusion-guided biopsy (FBx)...
February 21, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28216900/trichosanthes-kirilowii-exerts-androgenic-activity-via-regulation-of-psa-and-klk2-in-22rv1-prostate-cancer-cells
#2
Soo-Jin Jeong, Ji-Yoon Choi, Mi-Sook Dong, Chang-Seob Seo, Hyeun-Kyoo Shin
BACKGROUND: The androgen comprises a group of hormones that play roles in male reproductive activity as well as personal characteristics. OBJECTIVE: We investigated the androgenic activity of various herbal medicines in human prostate cancer 22Rv1 cells. MATERIALS AND METHODS: Herbal extracts of Trichosanthes kirilowii (TK), Asarum sieboldii (AS), Sanguisorba officinalis (SO), and Xanthium strumarium (XS) were selected to have androgenic effects based on a preliminary in vitro screening system...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28215847/prostate-cancer-screening-in-men-aged-50-to-69-years-sthlm3-a-prospective-population-based-diagnostic-study-gr%C3%A3-nberg-h-adolfsson-j-aly-m-nordstr%C3%A3-m-t-wiklund-p-brandberg-y-thompson-j-wiklund-f-lindberg-j-clements-m-egevad-l-eklund-m-lancet-oncol-2015-dec-16
#3
Eggener Scott, J Adolfsson, M Aly, T Nordström, P Wiklund, Y Brandberg, J Thompson, F Wiklund, J Lindberg, M Clements, L Egevad, M Eklund
BACKGROUND: The prostate-specific antigen (PSA) test is used to screen for prostate cancer but has a high false-positive rate that translates into unnecessary prostate biopsies and overdiagnosis of low-risk prostate cancers. We aimed to develop and validate a model to identify high-risk prostate cancer (with a Gleason score of at least 7) with better test characteristics than that provided by PSA screening alone. METHODS: The Stockholm 3 (STHLM3) study is a prospective, population-based, paired, screen-positive, diagnostic study of men without prostate cancer aged 50 to 69 years randomly invited by date of birth from the Swedish Population Register kept by the Swedish Tax Agency...
March 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28212119/the-role-of-biomarkers-in-undiagnosed-men
#4
Hasan Dani, Stacy Loeb
PURPOSE OF REVIEW: This article intends to review biomarkers derived from blood, urine, and tissue that can aid in the diagnosis of prostate cancer (PCa). RECENT FINDINGS: PCa screening requires tools that complement prostate-specific antigen (PSA) with a higher specificity for clinically significant disease. Novel blood biomarkers, such as the Prostate Health Index (phi) and 4Kscore, utilize isoforms of PSA to more accurately predict high-grade PCa than traditional tools such as PSA and the percentage free-to-total PSA...
February 16, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28210882/prostate-cancer-screening-decision-making-in-three-states-2013-behavioral-risk-factor-surveillance-system-analysis
#5
Jun Li, Ingrid J Hall, Guixiang Zhao
INTRODUCTION: Given the discordant prostate cancer screening recommendations in the United States, shared decision-making (SDM) has become increasingly important. The objectives of this study were to determine who made the final decision to obtain prostate-specific antigen (PSA)-based screening and identify factors associated with the screening decision made by both patients and their health care providers. METHODS: Using the 2013 Behavioral Risk Factor Surveillance System data from Delaware, Hawaii, and Massachusetts, we calculated weighted percentages of SDM...
February 16, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28162857/design-synthesis-and-biological-evaluation-of-2-4-phenylthiazol-2-yl-isoindoline-1-3-dione-derivatives-as-anti-prostate-cancer-agents
#6
K Saravanan, R Elancheran, S Divakar, S Athavan Alias Anand, M Ramanathan, Jibon Kotoky, N K Lokanath, S Kabilan
The structural modification and molecular docking-based screening approaches on thiazole-based isoindolinediones were imposed to find the novel 2-(4-phenylthiazol-2-yl) isoindoline-1,3-dione derivatives. The best fit compounds (6a-n) were synthesized and evaluated their antiproliferative activities on the prostate cancer cell lines (PC-3 & LNCaP). Among them, the compound, 6m exhibited good activity, particularly on LNCaP (IC50=5.96±1.6μM), moderately active against PC-3 cell lines as compared to bicalutamide...
January 25, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28152910/choosing-wisely-in-oncology-are-we-ready-for-value-based-care
#7
Doug Blayney, Mohammad Jahanzeb, Pamela Kadlubek, August Knape, Merry Jennifer Markham, Trang Pham, Tracey L Evans
: 275 Background: The Choosing Wisely (CW) Campaign challenges patients, healthcare providers, and specialty disease societies to make better decisions about healthcare delivery. In 2012, Schnipper et al. published ASCO's Top Five List targeting overuse of medications, tests, and procedures that are costly and lack evidence. 1.) Do not use cancer-directed therapy for patients with low performance status (undocumented, 3 or 4). 2.) Do not use PET, CT and radionuclide bone scans in the staging of early prostate cancer...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152876/choosing-wisely-in-oncology-screening-for-a-new-primary-cancer-in-patients-with-metastatic-disease
#8
Lorraine Lipscombe, Hadas Fischer, Jill Tinmouth, Peter Austin, Kinwah Fung, Matthew C Cheung
: 295 Background: The Choosing Wisely Canada (CWC) campaign aims to start conversations about unnecessary treatments and procedures in order to improve quality of care. In particular, the CWC campaign in cancer seeks to reduce interventions that are not supported by evidence and contribute to unnecessary rising costs of cancer care. We sought to document the performance of cancer screening for a new primary cancer in patients with existing metastatic cancer (CWC statement #2). METHODS: We used population-based administrative health care databases from Ontario, Canada held at the Institute for Clinical Evaluative Sciences (ICES)...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152837/discussions-of-cancer-screening-what-do-physicians-say-what-do-patients-hear-and-how-much-shared-decision-making-occurs
#9
Gina Aharonoff, Maureen Bezuhly, Jessica Herzstein, Michael P Osborne, Floyd Jackson Fowler
: 180 Background: Like other medical interventions, cancer screening requires shared decision-making (SDM). To better understand the process, we are performing a cluster-randomized trial of educational supports to improve screening guideline compliance for breast, cervical, colorectal, lung and prostate cancer at two urban academic medical centers. We present interim results that focus on recalled SDM discussions. METHODS: We are enrolling an age- and sex-stratified sample of 216 patients aged 30 to 89 years, 18 treated by each of 12 primary care physicians at two affiliated hospitals before a periodic physical examination...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152172/the-abc-model-of-prostate-cancer-a-conceptual-framework-for-the-design-and-interpretation-of-prognostic-studies
#10
REVIEW
Andreas Pettersson, Travis Gerke, Katja Fall, Yudi Pawitan, Lars Holmberg, Edward L Giovannucci, Philip W Kantoff, Hans-Olov Adami, Jennifer R Rider, Lorelei A Mucci
There has been limited success in identifying prognostic biomarkers in prostate cancer. A partial explanation may be that insufficient emphasis has been put on clearly defining what type of marker or patient category a biomarker study aims to identify and how different cohort characteristics affect the ability to identify such a marker. In this article, the authors put forth the ABC model of prostate cancer, which defines 3 groups of patients with localized disease that an investigator may seek to identify: patients who, within a given time frame, will not develop metastases even if untreated (category A), will not develop metastases because of radical treatment (category B), or will develop metastases despite radical treatment (category C)...
February 2, 2017: Cancer
https://www.readbyqxmd.com/read/28147335/promoter-methylation-of-mcam-er%C3%AE-and-er%C3%AE-in-serum-of-early-stage-prostate-cancer-patients
#11
Mariana Brait, Mithu Banerjee, Leonel Maldonado, Akira Ooki, Myriam Loyo, Elisa Guida, Evgeny Izumchenko, Leslie Mangold, Elizabeth Humphreys, Eli Rosenbaum, Alan Partin, David Sidransky, Mohammad Obaidul Hoque
BACKGROUND: Prostate cancer (PC) is the second most common cancer among men worldwide. Currently, the most common non-invasive approach for screening and risk assessment of PC is measuring the level of serum prostate-specific antigen (PSA). However, the sensitivity of PSA is 42.8 % and specificity is 41.1%. As a result, the serum PSA test leads to numerous unneeded biopsies. Therefore, a rigorous search for biomarkers for early detection of PC is ongoing. In this study, we aim to assess a panel of epigenetic markers in an intend to develop an early detection test for PC...
28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28139034/prostate-cancer-screening-practices-in-a-large-integrated-health-system-2007-2014
#12
Anita D Misra-Hebert, Bo Hu, Eric A Klein, Andrew Stephenson, Glen B Taksler, Michael W Kattan, Michael B Rothberg
OBJECTIVES: To assess prostate cancer (PCa) screening practices in primary care since the initial United States Preventive Services Task Force (USPSTF) recommendation against prostate specific antigen (PSA) testing for older men, and to assess primary provider variation associated with PCa screening. PATIENTS AND METHODS: Our study population included 160, 211 men age >= 40 with at least 1 visit in a primary care clinic in any of the study years in a large, integrated health system...
January 31, 2017: BJU International
https://www.readbyqxmd.com/read/28138251/apoptotic-induction-and-inhibition-of-nf-%C3%AE%C2%BAb-signaling-pathway-in-human-prostatic-cancer-pc3-cells-by-natural-compound-2-2-oxybis-4-allyl-1-methoxybenzene-biseugenol-b-from-litsea-costalis-an-in-vitro-study
#13
Maryam Abbaspour Babaei, Hasniza Zaman Huri, Behnam Kamalidehghan, Swee Keong Yeap, Fatemeh Ahmadipour
Litsea is considered as an evergreen genus distributed in tropical and subtropical Asia; this genus belongs to the large family of Lauraceae. In this study, the cell-death metabolism of biseugenol B was investigated. Nuclear condensation, cell permeability, mitochondrial membrane potential (MMP) and release of cytochrome c have been detected in human prostate cancer cell line (PC3) treated with biseugenol B by high content screening (HCS). Fluorescent analysis was conducted to examine the reactive oxygen species formation...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28129617/computational-study-involving-identification-of-endocrine-disrupting-potential-of-herbicides-its-implication-in-tds-and-cancer-progression-in-crpc-patients
#14
Md Irshad Ahmad, Afia Usman, Masood Ahmad
Several environmental pollutants, including herbicides, act as endocrine disrupting chemicals (EDCs). They can cause cancer, diabetes, obesity, metabolic diseases and developmental problems. Present study was conducted to screen 608 herbicides for evaluating their endocrine disrupting potential. The screening was carried out with the help of endocrine disruptome docking program, http://endocrinedisruptome.ki.si (Kolsek et al., 2013). This program screens the binding affinity of test ligands to 12 major nuclear receptors...
January 16, 2017: Chemosphere
https://www.readbyqxmd.com/read/28123076/cardiovascular-disease-in-cancer-survivors
#15
REVIEW
Tochi M Okwuosa, Sarah Anzevino, Ruta Rao
Certain cancer therapies, including radiation therapy and some types of chemotherapies, are associated with increased risk of cardiovascular disease (CVD) and events. Some of these effects such as those presented by anthracyclines, radiation therapy, cisplatin, as well as those presented by hormone therapy for breast cancer-usually taken for many years for some breast and prostate cancers-are long-lasting and associated with cardiovascular events risk more than 20 years after cancer treatment. Cardiovascular testing, diagnostic assessment of suspected cardiovascular symptomatology, as well as laboratory tests for CVD risk factors are imperative...
February 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28104375/estimate-of-opportunistic-prostate-specific-antigen-testing-in-the-finnish-randomized-study-of-screening-for-prostate-cancer
#16
Tuomas P Kilpeläinen, Dimitri Pogodin-Hannolainen, Kimmo Kemppainen, Kirsi Talala, Jani Raitanen, Kimmo Taari, Paula Kujala, Teuvo L J Tammela, Anssi Auvinen
PURPOSE: Screening for prostate cancer (PCa) remains controversial even if the European Randomized Study of Screening for Prostate Cancer (ERSPC) has shown a 21% relative reduction in PCa mortality. The Finnish Randomized Study of Screening for Prostate Cancer is the largest component of the ERSPC and showed statistically non-significant 16% mortality benefit in a separate analysis. The purpose of this study was to estimate the degree of contamination in the control arm (CA) of the Finnish trial...
January 16, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28104314/breast-prostate-and-thyroid-cancer-screening-tests-and-overdiagnosis
#17
Minsoo Jung
The purpose of this study was to examine overdiagnosis and overtreatment related to cancer screening and to review relevant reports and studies. A comprehensive search of peer-reviewed and gray literature was conducted for relevant studies published between January 2000 and December 2015 reporting breast, prostate, and thyroid cancer screening tests and overdiagnosis. This study revealed no dichotomy on where screening would lower risk or cause overdiagnosis and overtreatment. Many screening tests did both, that is, at population level, there were both benefit (decreased disease-specific mortality) and harm (overdiagnosis and overtreatment)...
December 20, 2016: Current Problems in Cancer
https://www.readbyqxmd.com/read/28100713/ahrr-cg05575921-hypomethylation-marks-smoking-behaviour-morbidity-and-mortality
#18
Stig E Bojesen, Nicholas Timpson, Caroline Relton, George Davey Smith, Børge G Nordestgaard
RATIONALE AND OBJECTIVES: Self-reported smoking underestimates disease risk. Smoking affects DNA methylation, in particular the cg05575921 site in the aryl hydrocarbon receptor repressor (AHRR) gene. We tested the hypothesis that AHRR cg05575921 hypomethylation is associated with risk of smoking-related morbidity and mortality. METHODS: From the Copenhagen City Heart Study representing the Danish general population, we studied 9234 individuals. Using bisulphite treated leucocyte DNA, AHRR (cg05575921) methylation was measured...
January 18, 2017: Thorax
https://www.readbyqxmd.com/read/28094251/is-prostate-cancer-stage-migration-continuing-for-black-men-in-the-psa-era
#19
R W Dobbs, D T Greenwald, H Wadhwa, V L Freeman, M R Abern
BACKGROUND: In the United States, disease-specific mortality from prostate cancer (PC) is highest among black men. While the introduction of widespread PSA testing has been associated with a downward stage migration, whether this trend continues in the late PSA era and for black men is unknown. The objective of our study was to evaluate current PC stage migration patterns in the United States by race. METHODS: The Surveillance, Epidemiology and End Results (SEER) registry was queried to obtain all cases of PC reported between 2000 and 2013...
January 17, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28092730/serum-agr2-as-a-useful-biomarker-for-pituitary-adenomas
#20
Mamatemin Tohti, Junyang Li, Chao Tang, Guodao Wen, Abdukeyum Abdujilil, Parhat Yizim, Chiyuan Ma
OBJECTIVE: This study aims to evaluate whether the serum Anterior Gradient-2 (AGR2) can be used as a potential biomarker screening in the diagnosis of Pituitary adenomas(PAs). PATIENTS AND METHODS: The serum AGR2 protein levels were preoperatively measured in 163 PA patients, 43 patients with other sellar lesions excluding PAs, 7 patients with prostate cancer as a positive control and 20 normal people(10 female and 10 male) using Enzyme-Linked ImmunoSorbent Assay (ELISA)...
January 9, 2017: Clinical Neurology and Neurosurgery
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