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Prostate Cancer Screening Test

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https://www.readbyqxmd.com/read/29142426/in-silico-and-in-vitro-anticancer-activity-of-isolated-novel-marker-compound-from-chemically-modified-bioactive-fraction-from-curcuma-longa-nccl
#1
Arshi Naqvi, Richa Malasoni, Swati Gupta, Akansha Srivastava, Rishi R Pandey, Anil Kumar Dwivedi
Background: Turmeric (Curcuma longa) is reported to possess wide array of biological activities. Herbal Medicament (HM) is a standardized hexane-soluble fraction of C. longa and is well known for its neuroprotective effect. Objective: In this study, we attempted to synthesize a novel chemically modified bioactive fraction from HM (NCCL) along with isolation and characterization of a novel marker compound (I). Materials and Methods: NCCL was prepared from HM...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29137895/a-four-kallikrein-panel-and-%C3%AE-microseminoprotein-in-predicting-high-grade-prostate-cancer-on-biopsy-an-independent-replication-from-the-finnish-section-of-the-european-randomized-study-of-screening-for-prostate-cancer
#2
Melissa Assel, Liisa Sjöblom, Teemu J Murtola, Kirsi Talala, Paula Kujala, Ulf-Håkan Stenman, Kimmo Taari, Anssi Auvinen, Andrew Vickers, Tapio Visakorpi, Teuvo L Tammela, Hans Lilja
BACKGROUND: A panel of four kallikrein markers (total, free, and intact prostate-specific antigen [PSA] and human kallikrein-related peptidase 2 [hK2]) improves predictive accuracy for Gleason score ≥7 (high-grade) prostate cancer among men biopsied for elevated PSA. A four-kallikrein panel model was originally developed and validated by the Dutch center of the European Randomized Study of Screening for Prostate Cancer (ERSPC). The kallikrein panel is now commercially available as 4Kscore™...
November 11, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29124241/us-preventive-services-task-force-prostate-specific-antigen-screening-guidelines-result-in-higher-gleason-score-diagnoses
#3
Glen Gejerman, Patrick Ciccone, Martin Goldstein, Vincent Lanteri, Burton Schlecker, John Sanzone, Michael Esposito, Sergey Rome, Michael Ciccone, Eric Margolis, Robert Simon, Yijun Guo, Sri-Ram Pentakota, Hossein Sadhegi-Nejad
Purpose: To evaluate the impact that the 2012 US Preventive Services Task Force (USPSTF) prostate-specific antigen (PSA) screening guidelines have had on the diagnosis of prostate cancer, we compared the incidence and distribution of new cases diagnosed in 2011-before the USPSTF PSA screening recommendations versus 2014 at which time the guidelines were widely adopted. Materials and Methods: We identified all prostate biopsies performed by a large urology group practice utilizing a centralized pathology lab...
November 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29118477/evaluation-of-the-efficacy-of-post-prostatic-massage-urine-cytology-in-diagnosis-of-various-prostatic-lesions-with-cytohistological-and-clinical-correlation
#4
Monisha Choudhury, Savita Agarwal
Background: Elderly men are at high risk of various prostatic diseases carrying high morbidity and mortality rates. For screening large populations, there is a need for a simple, reliable, and noninvasive test with high sensitivity and specificity. Exfoliated prostatic cancer cells can be harvested by prostatic massage and subjected to cytologic examination and molecular tests. Aims: This study was undertaken to evaluate the morphology of various prostatic lesions on post prostatic massage urine cytology and correlate cytologic, histologic, and clinical findings...
October 2017: Journal of Cytology
https://www.readbyqxmd.com/read/29118070/perceptions-of-oral-cancer-screenings-as-compared-to-other-cancer-screenings-a-pilot-study
#5
M Colleen Stephenson, JoAnn R Gurenlian, Denise M Bowen
Purpose: The purpose of this pilot study was to compare public perceptions of Idaho adults regarding oral cancer (OC) screening with other common cancer screenings including breast cancer (BC), prostate cancer (PC), and colon cancer (CC) screenings.Methods: This study utilized a convenience sample (N=100) of Idaho residents. A self-designed, validated interview-administered questionnaire was administered by a data collection service using computer-assisted telephone interview software to assess consumer perceptions about cancer screenings...
June 2017: Journal of Dental Hygiene: JDH
https://www.readbyqxmd.com/read/29114110/the-diagnosis-of-obstructive-hydronephrosis-with-color-doppler-ultrasound
#6
Petrit Nuraj, Nexhmi Hyseni
Background: The obstructive hydronephrosis is a term that implicates the structural and functional changes of the kidneys as a result of difficulties in the flow of urine. Hydronephrosis specifically describes dilation and swelling of the kidney. Hydronephrosis is a condition that typically occurs when the kidney swells due to the failure of normal drainage of urine from the kidney to the bladder. Our aim was to evaluate the degree of hydronephrosis, causes and diagnostic method. Material and...
September 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/29109592/nanomaterial-based-biosensors-for-detection-of-prostate-specific-antigen
#7
Dominika Damborska, Tomas Bertok, Erika Dosekova, Alena Holazova, Lenka Lorencova, Peter Kasak, Jan Tkac
Screening serum for the presence of prostate specific antigen (PSA) belongs to the most common approach for the detection of prostate cancer. This review (with 156 refs.) addresses recent developments in PSA detection based on the use of various kinds of nanomaterials. It starts with an introduction into the field, the significance of testing for PSA, and on current limitations. A first main section treats electrochemical biosensors for PSA, with subsections on methods based on the use of gold electrodes, graphene or graphene-oxide, carbon nanotubes, hybrid nanoparticles, and other types of nanoparticles...
July 14, 2017: Mikrochimica Acta
https://www.readbyqxmd.com/read/29106358/prostate-specific-antigen-testing-for-prostate-cancer-screening-a-national-survey-of-canadian-primary-care-physicians-opinions-and-practices
#8
Mitchell Geoffrey Goldenberg, Sean C Skeldon, Madhur Nayan, Yegappan Suppiah, Linda Chow, Elise Fryml, David Greenberg, Rajiv K Singal, S Larry Goldenberg
INTRODUCTION: In 2014, the Canadian Task Force on Preventive Health Care (CTFPHC) recommended against routine prostate cancer screening with the prostate-specific antigen (PSA) blood test.(1) We surveyed Canadian primary care physicians (PCPs) to understand their opinions and attitudes towards prostate cancer screening in 2016. METHODS: Twenty PCPs piloted the survey to assess its accessibility. We distributed a flyer to 19 633 PCPs as an insert in a large mailed package inviting them to attend a national meeting, and later promoted the survey at the meeting...
November 1, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29095457/attomolar-detection-of-extracellular-micrornas-released-from-living-prostate-cancer-cells-by-a-plasmonic-nanowire-interstice-sensor
#9
Siyeong Yang, Hongki Kim, Kyung Jin Lee, Seul Gee Hwang, Eun-Kyung Lim, Juyeon Jung, Tae Jae Lee, Hee-Sung Park, Taejoon Kang, Bongsoo Kim
Prostate cancer (PC) is the second leading cause of cancer death for men worldwide. The serum prostate-specific antigen level test has been widely used to screen for PC. This method, however, exhibits a high false-positive rate, leading to over-diagnosis and over-treatment of PC patients. Extracellular microRNAs (miRNAs) recently provided valuable information including the site and the status of the cancers and thus emerged as new biomarkers for several cancers. Among them, miR141 and miR375 are the most pronounced biomarkers for the diagnosis of high-risk PC...
November 16, 2017: Nanoscale
https://www.readbyqxmd.com/read/29078054/online-interactive-option-grid-patient-decision-aids-and-their-effect-on-user-preferences
#10
Peter Scalia, Marie-Anne Durand, Jan Kremer, Marjan Faber, Glyn Elwyn
BACKGROUND: Randomized trials have shown that patient decision aids can modify users' preferred healthcare options, but research has yet to identify the attributes embedded in these tools that cause preferences to shift. OBJECTIVES: The aim of this study was to investigate people's preferences as they used decision aids for 5 health decisions and, for each of the following: 1) determine if using the interactive Option Grid led to a pre-post shift in preferences; 2) determine which frequently asked questions (FAQs) led to preference shifts; 3) determine the FAQs that were rated as the most important as users compared options...
October 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/29066914/upregulation-of-long-noncoding-rna-loc440040-promotes-tumor-progression-and-predicts-poor-prognosis-in-patients-with-prostate-cancer
#11
Cheng Zhang, Chunlin Liu, Jie Wu, Yuxiao Zheng, Haoxiang Xu, Gong Cheng, Lixin Hua
BACKGROUND/PURPOSE: Long noncoding RNAs (lncRNAs) play a functional role in the initiation and progression of prostate cancer (PCa). This study aimed to determine differentially expressed lncRNA through high-throughput sequencing technology and investigate its expression, biological function and clinical correlation with PCa. MATERIALS AND METHODS: Candidate lncRNAs were identified through microarray screening and bioanalysis. The expression of lncRNA LOC440040 in PCa tissues and cell lines was determined by reverse-transcription polymerase chain reaction...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29061540/utility-of-digital-rectal-examination-dre-as-an-adjunct-to-prostate-specific-antigen-psa-in-the-detection-of-clinically-significant-prostate-cancer
#12
Joshua A Halpern, Clara Oromendia, Jonathan E Shoag, Sameer Mittal, Michael F Cosiano, Karla V Ballman, Andrew J Vickers, Jim C Hu
PURPOSE: Guidelines from the National Cancer Care Network (NCCN) advocate digital rectal examination (DRE) screening only in men with elevated prostate specific antigen (PSA). We sought to investigate the effect of PSA on the association between DRE and clinically significant prostate cancer (CSPC) in a large, US cohort. MATERIALS AND METHODS: Men who underwent DRE (n=35,350) within the screening arm of the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening trial were evaluated for development of CSPC (Gleason ≥ 7) with follow-up of 343,273 person-years...
October 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29059273/a-randomized-double-blind-placebo-controlled-phase-ii-study-of-maintenance-therapy-with-tasquinimod-in-patients-with-metastatic-castration-resistant-prostate-cancer-responsive-to-or-stabilized-during-first-line-docetaxel-chemotherapy
#13
K Fizazi, A Ulys, L Sengeløv, M Moe, S Ladoire, A Thiery-Vuillemin, A Flechon, A Guida, J Bellmunt, M A Climent, S Chowdhury, H Dumez, M Matouskova, N Penel, S Liutkauskiene, L Stachurski, C N Sternberg, F Baton, N Germann, G Daugaard
Background: This phase II study was conducted to assess clinical efficacy of tasquinimod maintenance therapy in patients with metastatic castrate-resistant prostate cancer not progressing during first-line docetaxel-based therapy. Patients and methods: Patients were randomly assigned (1 : 1) to receive tasquinimod (0.25-1.0 mg/day orally) or placebo. The primary end point was radiologic progression-free survival (rPFS); secondary efficacy end points included: overall survival (OS); PFS on next-line therapy (PFS 2) and symptomatic PFS, assessed using the Brief Pain Inventory (BPI) questionnaire and analgesic use...
November 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29054792/-management-of-prostate-cancer-in-patients-older-than-75%C3%A2-years
#14
Pierre Mongiat-Artus, Danièle Avenin
Prostate cancer is a disease of the elderly men. Prostate cancer in the elderly men is often poorly managed and under-treated. The digital rectal examination is an effective screening test for elderly prostate cancer patients. In order to choose the appropriated therapeutic option, evaluation of life-expectancy is essential to offer an optimal individualized treatment. It is essential to take into account the patients' aspirations before starting any diagnostic and therapeutic approach. Therapeutic options should be adapted in elderly prostate cancer patients according to their comorbidities and needs...
October 17, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/29051016/patterns-of-prostate-specific-antigen-test-use-in-the-u-s-2005-2015
#15
Zahava Berkowitz, Jun Li, Thomas B Richards, Pamela M Marcus
INTRODUCTION: Recommendations for prostate-specific antigen-based screening for prostate cancer are placing increasing emphasis on men aged 55-69 years. The goal of the current study is to describe patterns of population-based prostate-specific antigen testing with details about that age group. METHODS: National Health Interview Surveys from 2005 to 2015 were analyzed in 2017 to estimate routine prostate-specific antigen testing in the past year from self-reported data by age group (40-54, 55-69, ≥70 years), and also by risk group, defined as African American men or men with a family history of prostate cancer versus other men...
October 16, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29048660/canonical-and-non-canonical-wnt-signaling-in-cancer-stem-cells-and-their-niches-cellular-heterogeneity-omics-reprogramming-targeted-therapy-and-tumor-plasticity-review
#16
Masaru Katoh
Cancer stem cells (CSCs), which have the potential for self-renewal, differentiation and de-differentiation, undergo epigenetic, epithelial-mesenchymal, immunological and metabolic reprogramming to adapt to the tumor microenvironment and survive host defense or therapeutic insults. Intra-tumor heterogeneity and cancer-cell plasticity give rise to therapeutic resistance and recurrence through clonal replacement and reactivation of dormant CSCs, respectively. WNT signaling cascades cross-talk with the FGF, Notch, Hedgehog and TGFβ/BMP signaling cascades and regulate expression of functional CSC markers, such as CD44, CD133 (PROM1), EPCAM and LGR5 (GPR49)...
September 19, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29035180/ten-year-trends-in-preventive-service-use-before-and-after-prostate-cancer-diagnosis-a-comparison-with-noncancer-controls
#17
Lauren P Wallner, Jeffrey M Slezak, Ronald K Loo, Roshan Bastani, Steven J Jacobsen
CONTEXT: Few studies have assessed the longer-term quality of preventive care in prostate cancer (PCa) survivors. OBJECTIVE: To compare the rates of preventive services among PCa survivors five years before and after diagnosis, to men without PCa. DESIGN: Men enrolled in Kaiser Permanente Southern California with newly diagnosed PCa (2002-2008) were matched 1:1 to men without a PCa diagnosis on age, race, and timing of prostate-specific antigen test (N = 31,180)...
2017: Permanente Journal
https://www.readbyqxmd.com/read/29031682/-rates-of-total-and-free-psa-prescriptions-in-france-2012-2014
#18
Philippe Tuppin, Claire Leboucher, Gabrielle Peyre-Lanquar, Pierre-Jean Lamy, Pierre Gabach, Xavier Rébillard
BACKGROUND: In 2010, the French Haute Autorité de santé (National Health Authority) confirmed the limited value of prostate cancer (PCa) screening by total prostate-specific antigen (PSA) assay. OBJECTIVE: This study was designed to determine the modalities of ordering total PSA or free PSA assays (in the absence of PCa) according to various parameters and the corresponding sums reimbursed. METHODS: Men aged 40 years and older covered by the national health insurance general scheme (73% of the French population) between 2012 and 2014 were selected...
October 11, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/29025456/a-finger-or-not-prostate-examinations-by-non-urologists-at-a-south-african-academic-institution
#19
Kalli Spencer
BACKGROUND: According to the South African (SA) National Cancer Registry 2009, prostate cancer is the most commonly diagnosed solid-organ cancer in SA men: the incidence increases at ~3% every year, with 1/26 men developing prostate cancer in their lifetime and five men dying every day. Screening for prostate cancer by performing a digital rectal examination (DRE) adds to the sensitivity and specificity of serum prostate-specific antigen (PSA) testing and is an important component of the assessment for the early detection of prostate cancer...
June 30, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29023685/summary-statement-on-screening-for-prostate-cancer-in-europe
#20
Eveline A M Heijnsdijk, Chris H Bangma, Josep M Borràs, Tiago M de Carvalho, Xavier Castells, Martin Eklund, Josep A Espinàs, Markus Graefen, Henrik Grönberg, Iris Lansdorp-Vogelaar, Pim J van Leeuwen, Vera Nelen, Franz Recker, Monique J Roobol, Pieter Vandenbulcke, Harry J de Koning
The European Randomised Study of Screening for Prostate Cancer (ERSPC) showed that Prostate-Specific Antigen (PSA) based screening results in a significant prostate cancer mortality reduction. Although there are concerns on overdiagnosis and overtreatment, it has been shown that the benefits can outweigh the harms if screening is stopped in older ages to prevent overdiagnosis. A limited screening program (for example screening at ages 55-59 years), including active surveillance for men with low-risk tumors, can even be cost-saving, compared with testing in an opportunistic setting in the wrong ages, as currently in Europe...
October 12, 2017: International Journal of Cancer. Journal International du Cancer
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