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Threshold Regression

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https://www.readbyqxmd.com/read/28930598/enzymatically-modified-ldl-atherosclerosis-and-beyond-paving-the-way-to-acceptance
#1
Michael Torzewski
The eLDL (enzymatically modified LDL) hypothesis proposes that modification of LDL during atherogenesis occurs through the action of ubiquitous hydrolytic enzymes. eLDL is recognized by multiple macrophage receptors. Following cellular uptake, eLDL triggers atherosclerotic lesion initiation with reversion or progression depending on the balance between cholesterol insudation and depletion. The effects of eLDL on cellular constituents of the atherosclerotic lesion comprise both pro- and anti-inflammatory mechanisms...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930492/time-trends-in-concussion-symptom-presentation-and-assessment-methods-in-high-school-athletes
#2
Dustin W Currie, Matthew J Kraeutler, John B Schrock, Eric C McCarty, R Dawn Comstock
BACKGROUND: Concussion rates have increased significantly over the past decade. This may reflect an increase in the knowledge and diagnosis of the symptoms of a concussion rather than a true increase in the incidence. Assessing trends in the way that concussions are presenting to and being identified by clinicians over the same period may provide additional insight into the apparent rise in concussions. PURPOSE: To evaluate patterns of change in concussion symptom presentation, diagnostic/evaluation methods, and symptom resolution time reported for United States high school athletes from the 2007-2008 through 2014-2015 academic years...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28929165/proprioception-mediates-the-association-between-systemic-inflammation-and-muscle-weakness-in-patients-with-knee-osteoarthritis-results-from-the-amsterdam-osteoarthritis-cohort
#3
Tomasz Cudejko, Martin van der Esch, Marike van der Leeden, Jasmijn Holla, Leo D Roorda, Willem Lems, Joost Dekker
OBJECTIVES: To determine whether systemic inflammation is associated with poor proprioception; to confirm that systemic inflammation is associated with muscle weakness; and to determine whether poor proprioception mediates the association between systemic inflammation and muscle weakness in knee osteoarthritis. DESIGN: Cross-sectional study. SUBJECTS: A total of 689 participants with knee osteoarthritis from the Amsterdam Osteoarthritis (AMS-OA) cohort...
September 20, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28928036/vitamin-d-and-blood-pressure-among-u-s-adults-a-cross-sectional-examination-by-race-ethnicity-and-gender
#4
Abhishek Vishnu, Vasudha Ahuja
INTRODUCTION: The cross-sectional association of serum vitamin D levels with blood pressure and hypertension status among a representative sample of U.S. adults was examined. METHODS: Participants of the National Health and Nutrition Examination Survey from 2001 to 2010 were included in these analyses. Harmonizing of the vitamin D levels from 2001 to 2006 with vitamin D measurement from 2007 to 2010 was done using regression equations released by the Centers for Disease Control and Prevention...
September 16, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28925347/positive-psychosocial-factors-and-cognition-in-ethnically-diverse-older-adults
#5
Laura B Zahodne, Caitlin W-M Watson, Sonia Seehra, Michelle N Martinez
OBJECTIVES: Cross-sectional and longitudinal evidence from largely non-Hispanic White cohorts suggests that positive psychosocial factors, particularly self-efficacy and social support, may protect against late-life cognitive decline. Identifying potentially protective factors in racial/ethnic minority elders is of high importance due to their increased risk of Alzheimer's disease. The overall goal of this study was to characterize cross-sectional associations between positive psychosocial factors and cognitive domains among Black, Hispanic, and White older adults...
September 19, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28923869/the-impact-of-vancomycin-area-under-the-concentration-time-curve-guided-dosing-on-vancomycin-associated-nephrotoxicity-a-quasi-experiment
#6
Natalie A Finch, Evan J Zasowski, Kyle P Murray, Ryan P Mynatt, Jing J Zhao, Raymond Yost, Jason M Pogue, Michael J Rybak
Background: Evidence suggests maintaining vancomycin trough concentrations between 15 and 20 mg/L, as currently recommended, is frequently unnecessary to achieve the daily area under the concentration-time curve (AUC24h) target of ≥ 400 mg*h/L. Many patients with trough concentrations in this range have AUC24h in excess of the therapeutic threshold and within the exposure range associated with nephrotoxicity. Based on this, the Detroit Medical Center switched from trough concentration to AUC-guided dosing to minimize potentially unnecessary vancomycin exposure...
September 18, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28923834/is-chronic-dialysis-the-right-hard-renal-end-point-to-evaluate-renoprotective-drug-effects
#7
Misghina Weldegiorgis, Dick de Zeeuw, Jamie P Dwyer, Peter Mol, Hiddo J L Heerspink
BACKGROUND AND OBJECTIVES: RRT and doubling of serum creatinine are considered the objective hard end points in nephrology intervention trials. Because both are assumed to reflect changes in the filtration capacity of the kidney, drug effects, if present, are attributed to kidney protection. However, decisions to start RRT are not only on the basis of filtration capacity of the kidney, but also on other factors. We therefore compared the time to RRT with the time to a fixed eGFR threshold and assessed the effect of the renoprotective drug irbesartan on both components...
September 18, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28922378/relationships-of-orientation-discrimination-threshold-and-visual-acuity-with-macular-lesions-in-age-related-macular-degeneration
#8
Haojie Fu, Bin Zhang, Jianliang Tong, Harold Bedell, Hecheng Zhang, Yating Yang, Chaochao Nie, Yingdong Luo, Xiaoling Liu
PURPOSE: To measure visual acuity and metamorphopsia in patients with age-related macular degeneration (AMD) and to explore their relationship with macular lesions. METHODS: In this cross-sectional study, a total of 32 normal subjects (32 eyes) and 35 AMD patients (35 eyes) were recruited. They were categorized into 4 groups: normal, dry AMD, non-active wet AMD, and active wet AMD. Best-corrected visual acuity (BCVA) was measured using the Early Treatment Diabetic Retinopathy Study protocol...
2017: PloS One
https://www.readbyqxmd.com/read/28922230/optimal-dose-of-perineural-dexamethasone-to-prolong-analgesia-after-brachial-plexus-blockade-a-systematic-review-and-meta-analysis
#9
Kyle Robert Kirkham, Alain Jacot-Guillarmod, Eric Albrecht
BACKGROUND: Perineural dexamethasone has gained popularity in regional anesthesia to prolong analgesia duration. However, uncertainty remains regarding the optimal perineural dose. Clarification of this characteristic is of significant importance as the administration of dexamethasone may lead to dose-dependent complications. The objective of this meta-analysis was to define the optimal perineural dexamethasone dose to prolong analgesia after brachial plexus blockade for adult patients undergoing upper limb surgery...
September 14, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28922043/association-between-triglyceride-high-density-lipoprotein-ratio-and-hearing-impairment-in-a-korean-population
#10
Da Jung Jung, Jun Young Do, Kyu Hyang Cho, A Young Kim, Seok Hui Kang
OBJECTIVE: The aim of the present study was to evaluate the clinical association between triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio and hearing impairment in a Korean population. PATIENTS AND METHODS: This was a cross-sectional study (n=18,004). Participants were divided into 4 quartiles based on their TG/HDL-C ratio: first quartile (1Q), second quartile (2Q), third quartile (3Q), and fourth quartile (4Q). The threshold values at 0.5, 1, and 2 kHz were averaged to obtain the low- or mid-frequency pure-tone average (Low/Mid-Freq), and the values at 3, 4, and 6 kHz were averaged to obtain the high-frequency pure-tone average (High-Freq)...
September 18, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28919786/genetic-variants-in-long-noncoding-rna-h19-contribute-to-the-risk-of-breast-cancer-in-a-southeast-china-han-population
#11
Yuxiang Lin, Fangmeng Fu, Yazhen Chen, Wei Qiu, Songping Lin, Peidong Yang, Meng Huang, Chuan Wang
The long noncoding RNA (lncRNA) H19 is a maternally expressed imprinted gene that plays important roles in tumorigenesis, progression, and metastasis. However, the association between polymorphisms on H19 and breast cancer (BC) susceptibility has remained obscure. In this case-control study, we assessed the interaction between two lncRNA H19 single-nucleotide polymorphisms (SNPs) (rs217727 C>T, rs2839698 C>T) and the risk of BC in a Chinese Han population. In total, 1,005 BC cases and 1,020 healthy controls were enrolled in this study...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28919249/dosimetric-predictors-for-acute-esophagitis-during-radiation-therapy-for-lung-cancer-results-of-a-large-statewide-observational-study
#12
Peter Paximadis, Matthew Schipper, Martha Matuszak, Mary Feng, Shruti Jolly, Thomas Boike, Inga Grills, Larry Kestin, Benjamin Movsas, Kent Griffith, Gregory Gustafson, Jean Moran, Teamour Nurushev, Jeffrey Radawski, Lori Pierce, James Hayman
PURPOSE: The purpose of this study is to identify dosimetric variables that best predict for acute esophagitis in patients treated for locally advanced non-small cell lung cancer in a prospectively accrued statewide consortium. METHODS AND MATERIALS: Patients receiving definitive radiation therapy for stage II-III non-small cell lung cancer within the Michigan Radiation Oncology Quality Consortium were included in the analysis. Dose-volume histogram data were analyzed to determine absolute volumes (cc) receiving doses from 10 to 60 Gy (V10, V20, V30, V40, V50, and V60), as well as maximum dose to 2 cc (D2cc), mean dose (MD), and generalized equivalent uniform dose (gEUD)...
July 19, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28918955/shifts-in-the-relationship-between-motor-unit-recruitment-thresholds-versus-derecruitment-thresholds-during-fatigue
#13
Matt S Stock, Jacob A Mota
Muscle fatigue is associated with diminished twitch force amplitude. We examined changes in the motor unit recruitment versus derecruitment threshold relationship during fatigue. Nine men (mean age = 26 years) performed repeated isometric contractions at 50% maximal voluntary contraction (MVC) knee extensor force until exhaustion. Surface electromyographic signals were detected from the vastus lateralis, and were decomposed into their constituent motor unit action potential trains. Motor unit recruitment and derecruitment thresholds and firing rates at recruitment and derecruitment were evaluated at the beginning, middle, and end of the protocol...
September 14, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28918385/wall-enhancement-ratio-and-partial-wall-enhancement-on-mri-associated-with-the-rupture-of-intracranial-aneurysms
#14
Guang-Xian Wang, Li Wen, Sheng Lei, Qian Ran, Jin-Bo Yin, Zi-Li Gong, Dong Zhang
OBJECTIVES: To evaluate the risk factors for rupture of intracranial aneurysms (IAs) using high resolution MRI (HRMRI). METHODS: 91 consecutive patients with 106 IAs were reviewed from February 2016 to April 2017. Patients and IAs were divided into ruptured and unruptured groups. In addition to the clinical characteristics of the patients, the features of IAs (eg, shape) were evaluated by CT angiography, whereas wall thickness, enhanced patterns, and enhancement ratio (ER) were evaluated by MRI...
September 16, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28918145/short-communication-relationship-between-methods-for-measurement-of-serum-electrolytes-and-the-relationship-between-ionized-and-total-calcium-and-neutrophil-oxidative-burst-activity-in-early-postpartum-dairy-cows
#15
B M Leno, E M Martens, M J B Felippe, K P Zanzalari, J C Lawrence, T R Overton
The objectives of this study were to (1) compare a test for serum measurement of total Ca (tCa), Mg, and P (VetTest Chemistry Analyzer, IDEXX Laboratories Inc., Westbrook, ME) to reference methods (spectrophotometric assays on a Beckman Coulter 640e automated clinical chemistry analyzer; Beckman Coulter, Brea, CA), (2) determine the relationship between ionized Ca (iCa) and reference method tCa in the immediate postpartum period, and (3) assess the relative value of these blood Ca indices as predictors of neutrophil oxidative burst activity...
September 13, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28917564/impact-of-institutional-procedural-volume-on-in-hospital-outcomes-after-cardiac-resynchronization-therapy-device-implantation-united-states-national-database-2003-2011
#16
Ilhwan Yeo, Luke K Kim, Bruce B Lerman, Jim W Cheung
BACKGROUND: The relationship between hospital volume and outcomes for cardiac resynchronization therapy (CRT) implantations has not been well established. OBJECTIVES: To examine outcomes after CRT device implantation stratified on hospital volume based on a large, national inpatient database. METHODS: Using the National Inpatient Sample database, we identified all patients undergoing de novo CRT implants between 2003 and 2011. Hospitals were categorized according to tertiles of annual CRT procedural volume...
September 13, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28916622/quantification-and-determination-of-normal-123-i-meta-iodobenzylguanidine-heart-to-mediastinum-ratio-hmr-from-cardiac-spect-ct-and-correlation-with-planar-hmr
#17
Raza Alvi, Edward J Miller, Taraneh Hashemi Zonouz, Veronica Sandoval, Noor Tariq, Rachel Lampert, Albert J Sinusas, Yi-Hwa Liu
Assessment of cardiac (123)I-mIBG uptake relies on the heart-to-mediastinal ratio (HMR) derived from planar images. We have developed novel semi-automated quantitative methodologies for assessing HMR from single photon emission computed tomography (SPECT) images using a dedicated cardiac multi-pinhole SPECT/computerized tomography (CT) system and determined the lower limit of normal (LLN) SPECT-derived HMR and the correlation to planar-derived HMR. Methods: Twenty-one healthy volunteers were injected with (123)I-meta Iodobenzylguanidine ((123)I-mIBG) and imaged using two different cameras...
September 15, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28916601/gait-speed-can-predict-advanced-clinical-outcomes-in-patients-who-undergo-transcatheter-aortic-valve-replacement-insights-from-a-japanese-multicenter-registry
#18
Seiji Kano, Masanori Yamamoto, Tetsuro Shimura, Ai Kagase, Masanao Tsuzuki, Atsuko Kodama, Yutaka Koyama, Toshihiro Kobayashi, Kenichi Shibata, Norio Tada, Toru Naganuma, Motoharu Araki, Futoshi Yamanaka, Shinichi Shirai, Kazuki Mizutani, Minoru Tabata, Hiroshi Ueno, Kensuke Takagi, Akihiro Higashimori, Toshiaki Otsuka, Yusuke Watanabe, Kentaro Hayashida
BACKGROUND: Gait speed reflects an important factor of frailty and is associated with an increased risk of late mortality in patients with cardiac disease. This study sought to assess the prognostic value of gait speed in elderly patients who underwent transcatheter aortic valve replacement. METHODS AND RESULTS: We investigated the 5-m or 15-feet gait speed (m/sec) in 1256 patients who underwent transcatheter aortic valve implantation using data from the OCEAN-TAVI Japanese multicenter registry (Optimized Catheter Valvular Intervention-Transcatheter Aortic Valve Implantation)...
September 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28915801/body-mass-index-and-type-2-diabetes-in-thai-adults-defining-risk-thresholds-and-population-impacts
#19
Keren Papier, Catherine D'Este, Chris Bain, Cathy Banwell, Sam-Ang Seubsman, Adrian Sleigh, Susan Jordan
BACKGROUND: Body mass index (BMI) cut-off values (>25 and >30) that predict diabetes risk have been well validated in Caucasian populations but less so in Asian populations. We aimed to determine the BMI threshold associated with increased type 2 diabetes (T2DM) risk and to calculate the proportion of T2DM cases attributable to overweight and obesity in the Thai population. METHODS: Participants were those from the Thai Cohort Study who were diabetes-free in 2005 and were followed-up in 2009 and 2013 (n = 39,021)...
September 15, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28915459/relationships-of-co2-assimilation-rates-with-exposure-and-flux-based-o3-metrics-in-three-urban-tree-species
#20
Yansen Xu, Bo Shang, Xiangyang Yuan, Zhaozhong Feng, Vicent Calatayud
The relationships of CO2 assimilation under saturated-light conditions (Asat) with exposure- (AOTX, Accumulated Ozone exposure over a hourly Threshold of X ppb) and flux-based (PODY, Phytotoxic Ozone Dose over a hourly threshold Y nmol·m(-2)·s(-1)) O3 metrics was studied on three common urban trees, Fraxinus chinensis (FC), Platanus orientalis (PO) and Robinia pseudoacacia (RP). Parameterizations for a stomatal multiplicative model were proposed for the three species. RP was the species showing lower species-specific maximum stomatal conductance (gmax) and experiencing lower cumulative O3 uptake along the experiment, but in contrast it was the most sensitive to O3...
September 12, 2017: Science of the Total Environment
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