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Threshold Regression

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https://www.readbyqxmd.com/read/29355789/surgical-site-infection-in-spinal-metastasis-incidence-and-risk-factors
#1
Amer Sebaaly, Daniel Shedid, Ghassan Boubez, Fahed Zairi, Michelle Kanhonou, Sung-Joo Yuh, Zhi Wang
BACKGROUND: Surgical site infection (SSI) inspinal metastasis surgery represents the most common postoperative surgical complication with high morbidity and mortality. OBJECTIVE: Evaluate the incidence of SSI in spinal metastasis surgery and its risk factors. STUDY DESIGN: Retrospective analysis of a prospective collected data. METHODS: Preoperative, operative and post-operative data were collected together with the Modified Tokuhashi score and Frankel score at all time checkpoints...
January 17, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29355551/baseline-and-serial-brain-natriuretic-peptide-level-predicts-5-year-overall-survival-in-patients-with-pulmonary-arterial-hypertension-data-from-the-reveal-registry
#2
Robert P Frantz, Harrison W Farber, David B Badesch, C Greg Elliott, Adaani E Frost, Michael D McGoon, Carol Zhao, David R Mink, Mona Selej, Raymond L Benza
BACKGROUND: Plasma brain natriuretic peptide (BNP) level is a prognostic biomarker in pulmonary arterial hypertension (PAH). Its impact on long-term overall survival (OS) was investigated in REVEAL, a 5-year observational, multicenter, United States registry of patients with PAH. METHODS: Patients were aged ≥18 years, met right heart catheterization criteria at rest, had WHO Group I PAH, and BNP measurement at enrollment. Optimal BNP threshold was obtained via receiver operating characteristic curve analysis...
January 16, 2018: Chest
https://www.readbyqxmd.com/read/29355164/serum-level-of-prostate-specific-antigen-in-diabetic-patients-in-basrah-iraq
#3
Jasim N Al-Asadi, Lamia M Al-Naama, Muhannad M Abdul-Kareem, Fawzi C Mashkoor
OBJECTIVES: The aim of this study was to determine the effect of type 2 diabetes mellitus (DM) on the serum level of prostate-specific antigen (PSA) in men in Basrah, Iraq. PATIENTS AND METHODS: A case-control study was done including 70 confirmed type 2 diabetic patients and 70 non-diabetic persons. Data about age and family history of diabetes were collected. For diabetic patients, data related to disease history were also enquired about. Weight and height were measured and body mass index (BMI) was calculated...
October 2017: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29353712/cost-utility-of-collaborative-nurse-led-self-management-support-for-primary-care-patients-with-anxiety-depressive-or-somatic-symptoms-a-cluster-randomized-controlled-trial-the-smads-trial
#4
Thomas Grochtdreis, Thomas Zimmermann, Egina Puschmann, Sarah Porzelt, Judith Dams, Martin Scherer, Hans-Helmut König
BACKGROUND: Anxiety, depressive and somatoform disorders are highly prevalent and cause a huge economic burden. A nurse-led collaborative care intervention has been set up in order to improve self-management of patients with these mental disorders in primary care in Hamburg, Germany. The aim of this study was to determine the cost-utility of this nurse-led intervention from the health care payer perspective. METHODS: This analysis was part of a 12-month cluster-randomized controlled trial aiming to increase perceived self-efficacy of primary care patients with anxiety, depressive or somatic symptoms by collaborative nurse-led self-management support compared with routine care...
December 29, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29353385/the-relative-importance-of-clinical-economic-patient-values-and-feasibility-criteria-in-cancer-drug-reimbursement-in-canada-a-revealed-preferences-analysis-of-recommendations-of-the-pan-canadian-oncology-drug-review-2011-2017
#5
Chris Skedgel, Dominika Wranik, Min Hu
BACKGROUND: Most Canadian provinces and territories rely on the pan-Canadian Oncology Drug Review (pCODR) to provide recommendations regarding public reimbursement of cancer drugs. The pCODR review process considers four dimensions of value-clinical benefit, economic evaluation, patient-based values and adoption feasibility-but they do not define weights for individual decision criteria or an acceptable threshold for any of the criteria. Given this implicit review process, it is of interest to understand which factors appear to carry the most weight in pCODR recommendations using a revealed preferences approach...
January 20, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29353151/the-association-between-recreational-physical-activity-sedentary-time-and-colorectal-polyps-in-a-population-screened-for-colorectal-cancer
#6
Darren R Brenner, Eileen Shaw, Demetra H Yannitsos, Matthew T Warkentin, Nigel T Brockton, S Elizabeth McGregor, Susanna Town, Robert J Hilsden
PURPOSE: Regular recreational moderate to vigorous physical activity (rMVPA) has been previously associated with a reduced risk of colorectal cancer (CRC), however, few studies have examined the association of rMVPA with colorectal polyps, the pre-malignant precursor lesions. The objective of this study was to examine the associations between physical activity and sitting time and polyps at the time of screening. METHODS: We conducted a cross-sectional study of 2496 individuals undergoing screening-related colonoscopy in Calgary, Alberta, Canada...
January 17, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29351889/disentangling-the-effects-of-low-ph-and-metal-mixture-toxicity-on-macroinvertebrate-diversity
#7
Riccardo Fornaroli, Alessio Ippolito, Mari J Tolkkinen, Heikki Mykrä, Timo Muotka, Laurie S Balistrieri, Travis S Schmidt
One of the primary goals of biological assessment of streams is to identify which of a suite of chemical stressors is limiting their ecological potential. Elevated metal concentrations in streams are often associated with low pH, yet the effects of these two potentially limiting factors of freshwater biodiversity are rarely considered to interact beyond the effects of pH on metal speciation. Using a dataset from two continents, a biogeochemical model of the toxicity of metal mixtures (Al, Cd, Cu, Pb, Zn) and quantile regression, we addressed the relative importance of both pH and metals as limiting factors for macroinvertebrate communities...
January 16, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29350344/the-relationship-between-exercise-dose-and-health-related-quality-of-life-with-a-phase-iii-cardiac-rehabilitation-program
#8
Borja Del Pozo-Cruz, Graeme Carrick-Ranson, Stacey Reading, Paul Nolan, Lance C Dalleck
PURPOSE: To quantify the relationship between the change in exercise dose and health-related quality of life (HRQoL) in a cohort of patients participating in a community-based phase-3 cardiac rehabilitation (CR) program. METHODS: A retrospective, pre-experimental (no control group) design of 58 participants that completed a phase-3, 12-week exercise-based CR program was used to test the current hypothesis. Self-reported HRQoL (36-Item Short Form Health Survey Version 2, SF-36v2) was assessed prior and after completing the CR program...
January 19, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29348490/robot-assisted-radical-prostatectomy-vs-laparoscopic-and-open-retropubic-radical-prostatectomy-functional-outcomes-18-months-after-diagnosis-from-a-national-cohort-study-in-england
#9
Julie Nossiter, Arunan Sujenthiran, Susan C Charman, Paul J Cathcart, Ajay Aggarwal, Heather Payne, Noel W Clarke, Jan van der Meulen
BACKGROUND: Robot-assisted radical prostatectomy (RARP) has been rapidly adopted without robust evidence comparing its functional outcomes against laparoscopic radical prostatectomy (LRP) or open retropubic radical prostatectomy (ORP) approaches. This study compared patient-reported functional outcomes following RARP, LRP or ORP. METHODS: All men diagnosed with prostate cancer in England during April - October 2014 who underwent radical prostatectomy were identified from the National Prostate Cancer Audit and mailed a questionnaire 18 months after diagnosis...
January 18, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29347958/correlation-of-structural-defects-in-the-ascending-aortic-wall-to-ultrasound-parameters-benefits-for-decision-making-process-in-aortic-valve-surgery
#10
Saša D Borović, Milica M Labudović Borović, Ivan V Zaletel, Vera N Todorović, Petar A Dabić, Jelena T Rakočević, Jelena M Marinković-Erić, Predrag S Milojević
BACKGROUND: Histopathological changes in the ascending aorta wall in patients with severe tricuspid aortic valve (TAV) stenosis were graded and correlated to echocardiographic parameters. Objective was to associate threshold echocardiographic values with structural defects in the ascending aorta providing a tool to improve decision-making process in cases when simultaneous aortic valve replacement (AVR) and ascending aorta replacement is considered. METHODS: Biopsies from 108 TAV stenosis patients subjected to AVR were graded into three grades according to severity of aortic wall changes...
January 18, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29346798/uric-acid-in-the-follow-up-determines-30-decline-in-estimated-gfr-over-2-years-a-propensity-score-analysis
#11
Wen Xiu Chang, Ning Xu, Takanori Kumagai, Ryutaro Iijima, Kaito Waki, Masaki Yamanaka, Michito Nagura, Shigeyuki Arai, Yoshifuru Tamura, Shigeru Shibata, Yoshihide Fujigaki, Shunya Uchida
BACKGROUND/AIMS: Higher level of serum uric acid (SUA) predicts early entry to dialysis in chronic kidney disease (CKD) patients. However, a short-term effect of SUA remains to be elucidated using a novel surrogate endpoint. METHODS: Japanese CKD stage 3 to 4 patients were retrospectively examined (n= 701). The follow-up level of SUA was estimated as time-averaged uric acid (TA-UA). A propensity score for 6.0, 6.5 or 7.0 mg/dL of TA-UA was respectively calculated using baseline 23 covariates...
December 4, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29346780/prevention-of-aortic-dissection-suggests-a-diameter-shift-to-a-lower-aortic-size-threshold-for-intervention
#12
Ahmed M Mansour, Sven Peterss, Mohammad A Zafar, John A Rizzo, Hai Fang, Paris Charilaou, Bulat A Ziganshin, Umer M Darr, John A Elefteriades
BACKGROUND: Multiple studies have quantified the relationship between aortic size and risk of dissection. However, these studies estimated the risk of dissection without accounting for any increase in aortic size from the dissection process itself. OBJECTIVES: This study aims to compare aortic size before and after dissection and to evaluate the change in size consequent to the dissection itself. METHODS: Fifty-five consecutive patients (29 type A; 26 type B) with aortic dissection and incidental imaging studies prior to dissection were identified and compared to a control group of aneurysm patients (n = 205)...
January 19, 2018: Cardiology
https://www.readbyqxmd.com/read/29346104/characterization-and-modeling-of-tissue-thermal-conductivity-during-an-electrosurgical-joining-process
#13
Che-Hao Yang, Wei Li, Roland K Chen
Electrosurgical vessel joining is commonly performed in surgical procedures to maintain hemostasis. This process requires elevated temperature to denature the tissue and while compression is applied, the tissue can be joined together. The elevated temperature can cause thermal damages to the surrounding tissues. In order to minimize these damages, it is critical to understand how the tissue properties change and how that affects the thermal spread. The purpose of this study is to investigate the changes of tissue thermal conductivity and how the changes correlate to thermal dose during the joining process...
February 2018: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/29345516/association-between-weather-related-factors-and-cardiac-arrest-of-presumed-cardiac-etiology-a-prospective-observational-study-based-on-out-of-hospital-care-data
#14
Mario Hensel, Daniel Geppert, Jan F Kersten, Markus Stuhr, Jürgen Lorenz, Sebastian Wirtz, Thoralf Kerner
OBJECTIVE: The objective of this study was to determine the association between weather-related factors and out-of-hospital cardiac arrest (OHCA) of presumed cardiac etiology. METHODS: This was a prospective observational study performed in a prehospital setting. Data from the Emergency Medical Service in Hamburg (Germany) and data from the local weather station were evaluated over a 5-year period. Weather data (temperature, humidity, air pressure, wind speed) were obtained every minute and matched with the associated rescue mission data...
January 18, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29344350/the-sensitivity-of-the-human-thirst-response-to-changes-in-plasma-osmolality-a-systematic-review
#15
REVIEW
Fintan Hughes, Monty Mythen, Hugh Montgomery
Background: Dehydration is highly prevalent and is associated with adverse cardiovascular and renal events. Clinical assessment of dehydration lacks sensitivity. Perhaps a patient's thirst can provide an accurate guide to fluid therapy. This systematic review examines the sensitivity of thirst in responding to changes in plasma osmolality in participants of any age with no condition directly effecting their sense of thirst. Methods: Medline and EMBASE were searched up to June 2017...
2018: Perioperative Medicine
https://www.readbyqxmd.com/read/29340883/associations-of-coffee-consumption-and-caffeine-intake-with-mammographic-breast-density
#16
Lusine Yaghjyan, Graham Colditz, Bernard Rosner, Aleksandra Gasparova, Rulla M Tamimi
PURPOSE: Previous studies suggest that coffee and caffeine intake may be associated with reduced breast cancer risk. We investigated the association of coffee and caffeine intake with mammographic breast density by woman's menopausal status and, in postmenopausal women, by hormone therapy (HT). METHODS: This study included 4130 cancer-free women within the Nurses' Health Study and Nurses' Health Study II cohorts. Percent breast density (PD) was measured from digitized film mammograms using a computer-assisted thresholding technique and square root-transformed for the analysis...
January 17, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29340569/associations-of-the-top-20-alzheimer-disease-risk-variants-with-brain-amyloidosis
#17
Liana G Apostolova, Shannon L Risacher, Tugce Duran, Eddie C Stage, Naira Goukasian, John D West, Triet M Do, Jonathan Grotts, Holly Wilhalme, Kwangsik Nho, Meredith Phillips, David Elashoff, Andrew J Saykin
Importance: Late-onset Alzheimer disease (AD) is highly heritable. Genome-wide association studies have identified more than 20 AD risk genes. The precise mechanism through which many of these genes are associated with AD remains unknown. Objective: To investigate the association of the top 20 AD risk variants with brain amyloidosis. Design, Setting, and Participants: This study analyzed the genetic and florbetapir F 18 data from 322 cognitively normal control individuals, 496 individuals with mild cognitive impairment, and 159 individuals with AD dementia who had genome-wide association studies and 18F-florbetapir positron emission tomographic data from the Alzheimer's Disease Neuroimaging Initiative (ADNI), a prospective, observational, multisite tertiary center clinical and biomarker study...
January 16, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29339343/an-integrated-evaluation-of-some-faecal-indicator-bacteria-fib-and-chemical-markers-as-potential-tools-for-monitoring-sewage-contamination-in-subtropical-estuaries
#18
Ana Caroline Cabral, Jonathan S Stark, Hedda E Kolm, César C Martins
Sewage input and the relationship between chemical markers (linear alkylbenzenes and coprostanol) and fecal indicator bacteria (FIB, Escherichia coli and enterococci), were evaluated in order to establish thresholds values for chemical markers in suspended particulate matter (SPM) as indicators of sewage contamination in two subtropical estuaries in South Atlantic Brazil. Both chemical markers presented no linear relationship with FIB due to high spatial microbiological variability, however, microbiological water quality was related to coprostanol values when analyzed by logistic regression, indicating that linear models may not be the best representation of the relationship between both classes of indicators...
January 12, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29338968/an-alternative-tool-for-triaging-patients-with-possible-acute-coronary-symptoms-before-admission-to-a-chest-pain-unit
#19
Kuang-Chau Tsai, Ray F Lin, Chieh Lee, Ai-Hsien Li
OBJECTIVE: This study aimed to develop a triage tool to more effectively triage possible ACS patients presenting to the emergency department (ED) before admission to a protocol-driven chest pain unit (CPU). METHODS: Seven hundred ninety-three clinical cases, randomly selected from 7962 possible ACS cases, were used to develop and test an ACS triage model using cluster analysis and stepwise logistic regression. RESULTS: The ACS triage model, logit (suspected ACS patient)=-5...
December 13, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29337760/using-thresholds-in-noise-to-identify-hidden-hearing-loss-in-humans
#20
Courtney L Ridley, Judy G Kopun, Stephen T Neely, Michael P Gorga, Daniel M Rasetshwane
OBJECTIVES: Recent animal studies suggest that noise-induced synaptopathy may underlie a phenomenon that has been labeled hidden hearing loss (HHL). Noise exposure preferentially damages low spontaneous-rate auditory nerve fibers, which are involved in the processing of moderate- to high-level sounds and are more resistant to masking by background noise. Therefore, the effect of synaptopathy may be more evident in suprathreshold measures of auditory function, especially in the presence of background noise...
January 15, 2018: Ear and Hearing
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