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Threshold Regression

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https://www.readbyqxmd.com/read/28107741/building-related-symptoms-are-linked-to-the-in-vitro-toxicity-of-indoor-dust-and-airborne-microbial-propagules-in-schools-a-cross-sectional-study
#1
J T Salin, M Salkinoja-Salonen, P J Salin, K Nelo, T Holma, P Ohtonen, H Syrjälä
INTRODUCTION: Indoor microbial toxicity is suspected to cause some building-related symptoms, but supporting epidemiological data are lacking. OBJECTIVE: We examined whether the in vitro toxicity of indoor samples from school buildings was associated with work-related health symptoms (building-related symptoms, BRS). METHODS: Administrators of the Helsinki City Real Estate Department selected 15 schools for the study, and a questionnaire on symptoms connected to work was sent to the teachers in the selected schools for voluntary completion...
January 17, 2017: Environmental Research
https://www.readbyqxmd.com/read/28106567/fractional-anisotropy-and-mean-diffusion-as-measures-of-dopaminergic-function-in-parkinson-s-disease-challenging-results
#2
Niklas Lenfeldt, Johan Eriksson, Björn Åström, Lars Forsgren, Susanna Jakobson
BACKGROUND: Diffusion tensor imaging (DTI) has been purported as an imaging technique to assess dopaminergic degeneration in Parkinson's disease. OBJECTIVE: To test if fractional anisotropy (FA) and mean diffusion (MD) in the basal ganglia as measured by DTI correlates with dopaminergic function as measured by dopamine transporter (DAT) and dopamine D2-receptor (D2R) SPECT. METHODS: One-hundred and eleven patients with Parkinson's disease (71±10 years) and thirty-one controls (68±7 years) performed DTI, DAT and D2R SPECT at baseline and four follow-ups (1-year: 89 patients/zero controls; 3-year: 72/11; 5-year: 48/17; and 8-year: 13/13)...
January 17, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28105520/type-1-diabetic-patients-with-peripheral-neuropathy-have-pan-enteric-prolongation-of-gastrointestinal-transit-times-and-an-altered-caecal-ph-profile
#3
Adam D Farmer, Anne Grave Pedersen, Birgitte Brock, Poul Erik Jakobsen, Jesper Karmisholt, Sahar D Mohammed, S Mark Scott, Asbjørn Mohr Drewes, Christina Brock
AIMS/HYPOTHESIS: We hypothesised that type 1 diabetic patients with established diabetic sensorimotor polyneuropathy (DSPN) would have segmental and/or pan-enteric dysmotility in comparison to healthy age-matched controls. We aimed to investigate the co-relationships between gastrointestinal function, degree of DSPN and clinical symptoms. METHODS: An observational comparison was made between 48 patients with DSPN (39 men, mean age 50 years, range 29-71 years), representing the baseline data of an ongoing clinical trial (representing a secondary analysis of baseline data collected from an ongoing double-blind randomised controlled trial investigating the neuroprotective effects of liraglutide) and 41 healthy participants (16 men, mean age 49 years, range 30-78) who underwent a standardised wireless motility capsule test to assess gastrointestinal transit...
January 20, 2017: Diabetologia
https://www.readbyqxmd.com/read/28102641/evidence-of-a-reduction-over-time-in-the-behavioral-severity-of-autistic-disorder-diagnoses
#4
Andrew J O Whitehouse, Matthew N Cooper, Keely Bebbington, Gail Alvares, Ashleigh Lin, John Wray, Emma J Glasson
The increasing prevalence of Autism Spectrum Disorders (ASD) may in part be due to a shift in the diagnostic threshold that has led to individuals with a less severe behavioral phenotype receiving a clinical diagnosis. This study examined whether there were changes over time in the qualitative and quantitative phenotype of individuals who received the diagnosis of Autistic Disorder. Data were from a prospective register of new diagnoses in Western Australia (n = 1252). From 2000 to 2006, we examined differences in both the percentage of newly diagnosed cases that met each criterion as well as severity ratings of the behaviors observed (not met, partially met, mild/moderate and extreme)...
January 19, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28102331/investigating-causality-in-associations-between-smoking-initiation-and-schizophrenia-using-mendelian-randomization
#5
Suzanne H Gage, Hannah J Jones, Amy E Taylor, Stephen Burgess, Stanley Zammit, Marcus R Munafò
Smoking is strongly associated with schizophrenia. Although it has been widely assumed that this reflects self-medication, recent studies suggest that smoking may be a risk factor for schizophrenia. We performed two-sample bi-directional Mendelian randomization using summary level genomewide association data from the Tobacco And Genetics Consortium and Psychiatric Genomics Consortium. Variants associated with smoking initiation and schizophrenia were combined using an inverse-variance weighted fixed-effects approach...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28101697/predictors-of-the-usefulness-of-corticosteroids-for-cancer-related-fatigue-in-end-of-life-patients
#6
Yuko Kanbayashi, Toyoshi Hosokawa
BACKGROUND AND OBJECTIVES: Although some studies have examined the use of corticosteroids, their effectiveness in treating cancer-related fatigue (CRF) has yet to be established. Therefore, this retrospective study attempted to identify factors that would predict the usefulness of corticosteroids in treating CRF. METHODS: We examined 87 hospitalized end-of-life cancer patients who were given betamethasone for relief of CRF at our hospital between January 2008 and January 2014...
January 18, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28100438/high-dose-rifampicin-moxifloxacin-and-sq109-for-treating-tuberculosis-a-multi-arm-multi-stage-randomised-controlled-trial
#7
Martin J Boeree, Norbert Heinrich, Rob Aarnoutse, Andreas H Diacon, Rodney Dawson, Sunita Rehal, Gibson S Kibiki, Gavin Churchyard, Ian Sanne, Nyanda E Ntinginya, Lilian T Minja, Robert D Hunt, Salome Charalambous, Madeleine Hanekom, Hadija H Semvua, Stellah G Mpagama, Christina Manyama, Bariki Mtafya, Klaus Reither, Robert S Wallis, Amour Venter, Kim Narunsky, Anka Mekota, Sonja Henne, Angela Colbers, Georgette Plemper van Balen, Stephen H Gillespie, Patrick P J Phillips, Michael Hoelscher
BACKGROUND: Tuberculosis is the world's leading infectious disease killer. We aimed to identify shorter, safer drug regimens for the treatment of tuberculosis. METHODS: We did a randomised controlled, open-label trial with a multi-arm, multi-stage design. The trial was done in seven sites in South Africa and Tanzania, including hospitals, health centres, and clinical trial centres. Patients with newly diagnosed, rifampicin-sensitive, previously untreated pulmonary tuberculosis were randomly assigned in a 1:1:1:1:2 ratio to receive (all orally) either 35 mg/kg rifampicin per day with 15-20 mg/kg ethambutol, 20 mg/kg rifampicin per day with 400 mg moxifloxacin, 20 mg/kg rifampicin per day with 300 mg SQ109, 10 mg/kg rifampicin per day with 300 mg SQ109, or a daily standard control regimen (10 mg/kg rifampicin, 5 mg/kg isoniazid, 25 mg/kg pyrazinamide, and 15-20 mg/kg ethambutol)...
January 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28100264/cross-sectional-examination-of-musculoskeletal-conditions-and-multimorbidity-influence-of-different-thresholds-and-definitions-on-prevalence-and-association-estimates
#8
Dianne B Lowe, Michael J Taylor, Sophie J Hill
BACKGROUND: Multimorbidity and musculoskeletal conditions create substantial burden for people and health systems. Quantifying the extent of co-occurring conditions is hampered by conceptual heterogeneity, imprecision and/or indecision about how multimorbidity is defined. The purpose of this study is to examine the influence of different ways of operationalising multimorbidity on multimorbidity prevalence rates with a focus on working-age adults with musculoskeletal conditions. Weighted population prevalence rates of multimorbidity among working-age Australians were estimated using data from the National Health Survey...
January 18, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28097295/association-of-systemic-medication-use-with-intraocular-pressure-in-a-multiethnic-asian-population-the-singapore-epidemiology-of-eye-diseases-study
#9
Henrietta Ho, Yuan Shi, Jacqueline Chua, Yih-Chung Tham, Sing Hui Lim, Tin Aung, Tien Yin Wong, Ching-Yu Cheng
Importance: There is limited understanding of the associations between systemic medication use and intraocular pressure (IOP) in the general population. Objective: To examine the association between systemic medication use and IOP in a multiethnic Asian population. Design, Setting, and Participants: In this post hoc analysis of the Singapore Epidemiology of Eye Diseases study, a population-based study of 10 033 participants (78.7% response rate) from 3 racial/ethnic groups (Chinese [recruited from February 9, 2009, through December 19, 2011], Malays [recruited from August 16, 2004, though July 10, 2006], and Indians [recruited from May 21, 2007, through December 29, 2009]), participants with glaucoma, previous ocular surgery, or trauma and an IOP asymmetry greater than 5 mm Hg between eyes were excluded...
January 12, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28096065/patient-specific-predictive-modeling-using-random-forests-an-observational-study-for-the-critically-ill
#10
Joon Lee
BACKGROUND: With a large-scale electronic health record repository, it is feasible to build a customized patient outcome prediction model specifically for a given patient. This approach involves identifying past patients who are similar to the present patient and using their data to train a personalized predictive model. Our previous work investigated a cosine-similarity patient similarity metric (PSM) for such patient-specific predictive modeling. OBJECTIVE: The objective of the study is to investigate the random forest (RF) proximity measure as a PSM in the context of personalized mortality prediction for intensive care unit (ICU) patients...
January 17, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/28096032/creation-of-an-intensive-care-unit-and-organizational-changes-in-an-adult-emergency-department-impact-on-acute-stroke-management
#11
Laurent Puy, Chantal Lamy, Sandrine Canaple, Audrey Arnoux, Nicolas Laine, Ella Iacob, Jean-Marc Constans, Olivier Godefroy
BACKGROUND AND PURPOSE: Following the reorganization of a University Medical Center onto a single campus, an Intensive Care Unit was created within the adult Emergency Department (ED ICU). We assessed the effects of these organizational changes on acute stroke management and the intravenous administration of recombinant tissue plasminogen activator (IV rtPA), as characterized by the thrombolysis rate, door-to-needle time (DNT) and outcome at 3months. METHODS: Between October 2013 and September 2015, we performed a retrospective, observational, single-center, comparative study of patients admitted for ischemic stroke and treated with IV rtPA during two 321-day periods (before and after the creation of the ED ICU)...
January 10, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28095833/lifetime-and-12-month-prevalence-of-eating-disorders-amongst-women-in-mid-life-a-population-based-study-of-diagnoses-and-risk-factors
#12
Nadia Micali, Maria G Martini, Jennifer J Thomas, Kamryn T Eddy, Radha Kothari, Ellie Russell, Cynthia M Bulik, Janet Treasure
BACKGROUND: Eating disorders (EDs) are common amongst women; however, no research has specifically investigated the lifetime/12-month prevalence of eating disorders amongst women in mid-life (i.e., fourth and fifth decade of life) and the relevant longitudinal risk factors. We aimed to investigate the lifetime and 12-month prevalence of EDs and lifetime health service use and to identify childhood, parenting, and personality risk factors. METHODS: This is a two-phase prevalence study, nested within an existing longitudinal community-based sample of women in mid-life...
January 17, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28095808/associations-between-access-to-alcohol-outlets-and-alcohol-intake-and-depressive-symptoms-in-women-from-socioeconomically-disadvantaged-neighbourhoods-in-australia
#13
Karen E Lamb, Lukar E Thornton, Megan Teychenne, Catherine Milte, Ester Cerin, Kylie Ball
BACKGROUND: This study examined associations between alcohol outlet access and alcohol intake, depressive symptoms score and risk of depression among women residing in disadvantaged neighbourhoods in Victoria, Australia. METHODS: Data on depressive symptoms, alcohol intake and socio-demographic characteristics were obtained from a sample of 995 adult women from Victoria, Australia who were surveyed as part of the Resilience in Eating and Activity Despite Inequality (READI) study...
January 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28095137/diabetes-mellitus-and-obesity-in-the-french-caribbean-a-special-vulnerability-for-women
#14
Philippe Carrère, Cédric Fagour, Dan Sportouch, Franciane Gane-Troplent, Jeannie Hélène-Pelage, Thierry Lang, Jocelyn Inamo
The objective of this study was to analyze the prevalence, awareness, treatment, and control of diabetes and its risk factors among French Caribbean adults. This cross-sectional study included 18-74-year-olds (N = 2252; 56.5% women) who underwent a heath examination in Guadeloupe during July-December 2014. Diabetes was defined as using antidiabetic treatment, or fasting glucose ≥7 mmol/l, and HbA1c ≥6.5%; diabetes control was defined as HbA1c <7%. Multilevel logistic regression was used. Diabetes prevalence was 8...
January 17, 2017: Women & Health
https://www.readbyqxmd.com/read/28095033/detection-of-the-toughest-pedestrian-injury-risk-as-a-smooth-function-of-age
#15
Tobias Niebuhr, Mirko Junge
OBJECTIVE: While it is common to regard age-specific groups (e.g. children, adults, elderly), smooth trends conditional on the age are mainly ignored in the literature. The present study examines the pedestrian injury risk in full-frontal pedestrian to passenger car accidents and incorporates the age -besides the collision speed and the injury severity- as a plug-in parameter. METHODS: Recent work introduced a model for pedestrian injury risk functions using explicit formulae with easily interpretable model parameters...
January 17, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28094323/gene-set-based-association-analyses-for-the-wssv-resistance-of-pacific-white-shrimp-litopenaeus-vannamei
#16
Yang Yu, Jingwen Liu, Fuhua Li, Xiaojun Zhang, Chengsong Zhang, Jianhai Xiang
White Spot Syndrome Virus (WSSV) is regarded as a virus with the strongest pathogenicity to shrimp. For the threshold trait such as disease resistance, marker assisted selection (MAS) was considered to be a more effective approach. In the present study, association analyses of single nucleotide polymorphisms (SNPs) located in a set of immune related genes were conducted to identify markers associated with WSSV resistance. SNPs were detected by bioinformatics analysis on RNA sequencing data generated by Illimina sequencing platform and Roche 454 sequencing technology...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28093836/incremental-validity-of-weight-suppression-in-predicting-clinical-impairment-in-bulimic-syndromes
#17
Kelsey E Hagan, Kelsey E Clark, Kelsie T Forbush
Research has shown that weight suppression (WS; the difference between a person's highest and current body weight in pounds) is a robust predictor of weight gain and eating-disorder (ED) symptoms among individuals with bulimic syndromes. Given the important prognostic role that WS plays in ED course and outcome, we hypothesized that WS would represent a clinically useful indicator of impairment for bulimic syndromes. We further posited that WS would demonstrate incremental validity above-and-beyond other proposed indicators in explaining clinical impairment in bulimic syndromes...
January 17, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28093719/metabolic-nodal-response-as-a-prognostic-marker-after-neoadjuvant-therapy-for-oesophageal-cancer
#18
J M Findlay, K M Bradley, L M Wang, J M Franklin, E J Teoh, F V Gleeson, N D Maynard, R S Gillies, M R Middleton
BACKGROUND: The ability to predict recurrence and survival after neoadjuvant chemotherapy (NAC) and surgery for oesophageal cancer remains elusive. This study evaluated the role of [(18) F]fluorodeoxyglucose (FDG) PET-CT in assessing tumour and nodal response as a prognostic marker. METHODS: This was a single-centre UK cohort study. From 2006 to 2014, patients with oesophageal cancer staged with PET-CT before NAC, and restaged by CT or PET-CT before resection, were included...
January 17, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28092524/code-coherence-based-decision-boundaries-for-feature-correspondence
#19
Wen-Yan Lin, Fan Wang, Ming-Ming Cheng, Sai-Kit Yeung, Philip H S Torr, Minh N Do, Jiangbo Lu
A key challenge in feature correspondence is the difficulty in differentiating true and false matches at a local descriptor level. This forces adoption of strict similarity thresholds that discard many true matches. However, if analyzed at a global level, false matches are usually randomly scattered while true matches tend to be coherent (clustered around a few dominant motions), thus creating a coherence based separability constraint. This paper proposes a non-linear regression technique that can discover such a coherence based separability constraint from highly noisy matches and embed it into a correspondence likelihood model...
January 16, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28091565/-18-f-flt-and-18-f-fdg-pet-ct-in-predicting-response-to-chemoradiotherapy-in-nasopharyngeal-carcinoma-preliminary-results
#20
Shi Qi, Yang Zhongyi, Zhang Yingjian, Hu Chaosu
The purpose of this study was to explore the feasibility of (18)F-Fluorothymidine ((18)F-FLT) and (18)F-Fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) in predicting treatment response of nasopharyngeal carcinoma (NPC). Patients with NPC of Stage II-IVB were prospectively enrolled, receiving 2 cycles of neoadjuvant chemotherapy (NACT), followed by concurrent chemoradiotherapy. Each patient underwent pretreatment and post-NACT FLT PET/CT and FDG PET/CT. Standard uptake values (SUV) and tumor volume were measured...
January 16, 2017: Scientific Reports
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