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https://www.readbyqxmd.com/read/27911486/extended-mortality-results-for-prostate-cancer-screening-in-the-plco-trial-with-median-follow-up-of-15-years
#1
Paul F Pinsky, Philip C Prorok, Kelly Yu, Barnett S Kramer, Amanda Black, John K Gohagan, E David Crawford, Robert L Grubb, Gerald L Andriole
BACKGROUND: Two large-scale prostate cancer screening trials using prostate-specific antigen (PSA) have given conflicting results in terms of the efficacy of such screening. One of those trials, the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, previously reported outcomes with 13 years of follow-up. This study presents updated findings from the PLCO trial. METHODS: The PLCO trial randomized subjects from 1993 to 2001 to an intervention or control arm...
December 1, 2016: Cancer
https://www.readbyqxmd.com/read/27906455/insights-from-the-plco-trial-about-prostate-cancer-screening
#2
EDITORIAL
Roman Gulati, Peter C Albertsen
No abstract text is available yet for this article.
December 1, 2016: Cancer
https://www.readbyqxmd.com/read/27845108/re-lethal-prostate-cancer-in-the-plco-cancer-screening-trial
#3
Samir S Taneja
No abstract text is available yet for this article.
December 2016: Journal of Urology
https://www.readbyqxmd.com/read/27837443/do-cancer-survivors-develop-healthier-lifestyle-behaviors-than-the-cancer-free-population-in-the-plco-study
#4
Makenzie L Hawkins, Saundra S Buys, Lisa H Gren, Sara E Simonsen, Anne C Kirchhoff, Mia Hashibe
BACKGROUND: Current studies report mixed results in health status and health behaviors after a diagnosis of cancer. The aim of our study is to investigate potential differences in lifestyle factors among cancer survivors and cancer-free individuals in a prospective cohort study conducted in the United States. METHODS: Using data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Trial, 10,133 cancer survivors were identified and compared to 81,992 participants without cancer to evaluate differences in body mass index (BMI), smoking, NSAID use, and physical activity...
November 11, 2016: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/27823819/re-reevaluating-psa-testing-rates-in-the-plco-trial
#5
Peter Albers
No abstract text is available yet for this article.
November 4, 2016: European Urology
https://www.readbyqxmd.com/read/27810449/detection-of-high-grade-prostate-cancer-among-plco-participants-using-a-prespecified-four-kallikrein-marker-panel
#6
Eric H Kim, Gerald L Andriole, E David Crawford, Daniel D Sjoberg, Melissa Assel, Andrew J Vickers, Hans Lilja
PURPOSE: To assess the performance of a four-kallikrein panel, with and without microseminoprotein-beta (MSP), to predict high-grade (Gleason 7+, Gleason Grade Group 2+) prostate cancer (PCa) on biopsy in a multiethnic cohort from the Prostate, Lung, Colorectal, and Ovarian (PLCO) cancer screening trial. MATERIALS AND METHODS: Levels of free, intact, total prostate-specific antigen (PSA), human kallikrein-2, and MSP were measured blinded to outcome in cryo-preserved serum from men in the intervention arm of PLCO...
October 31, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27770434/pre-diagnostic-circulating-inflammation-markers-and-endometrial-cancer-risk-in-the-prostate-lung-colorectal-and-ovarian-cancer-plco-screening-trial
#7
Britton Trabert, Ronald C Eldridge, Ruth M Pfeiffer, Meredith S Shiels, Troy J Kemp, Chantal Guillemette, Patricia Hartge, Mark E Sherman, Louise A Brinton, Amanda Black, Anil K Chaturvedi, Allan Hildesheim, Sonja I Berndt, Mahboobeh Safaeian, Ligia Pinto, Nicolas Wentzensen
Inflammation is proposed to increase risk of developing endometrial cancer, but few prospective epidemiologic studies have investigated the relationship between circulating inflammation markers and endometrial cancer risk. In a nested case-control study within the PLCO Screening Trial we measured serum levels of 64 inflammation-related biomarkers in 284 incident endometrial cancer cases and 284 matched controls. Using multivariable logistic regression inflammation markers were evaluated individually and combined into a cross-validated inflammation score...
October 22, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27754927/prediagnostic-body-mass-index-trajectories-in-relation-to-prostate-cancer-incidence-and-mortality-in-the-plco-cancer-screening-trial
#8
Scott P Kelly, Barry I Graubard, Gabriella Andreotti, Naji Younes, Sean D Cleary, Michael B Cook
BACKGROUND: Evidence suggests that obesity in adulthood is associated with increased risk of "clinically significant" prostate cancer. However, studies of body mass index (BMI) across the adult life course and prostate cancer risks remain limited. METHODS: In a prospective cohort of 69 873 men in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, we examined associations of prediagnostic BMI across the adult life course with risk of incident prostate cancer and fatal prostate cancer (prostate cancer-specific mortality)...
March 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/27732807/more-on-reevaluating-psa-testing-rates-in-the-plco-trial
#9
LETTER
Paul Pinsky, Philip Prorok
No abstract text is available yet for this article.
October 13, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27732806/more-on-reevaluating-psa-testing-rates-in-the-plco-trial
#10
LETTER
(no author information available yet)
No abstract text is available yet for this article.
October 13, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27699819/prostate-specific-antigen-growth-curve-model-to-predict-high-risk-prostate-cancer
#11
Azza Shoaibi, Gowtham A Rao, Bo Cai, John Rawl, Kathlyn Sue Haddock, James R H├ębert
PURPOSE: To investigate if a prostate specific antigen (PSA)-derived growth curve can predict the occurrence of high-risk prostate cancer (PrCA). METHODS: Data from 38,340 men randomized to the PrCA screening arm in the prostate, lung, colorectal, and ovarian cancer screening trial (PLCO) were used to develop a PSA growth curve model to estimate PSA rate of change. The model was then used to predict high-risk PrCA in clinical data available from 680,390 veterans seeking routine care...
October 4, 2016: Prostate
https://www.readbyqxmd.com/read/27687075/active-follow-up-versus-passive-linkage-with-cancer-registries-for-case-ascertainment-in-a-cohort
#12
P F Pinsky, K Yu, A Black, W Y Huang, P C Prorok
BACKGROUND: Ascertaining incident cancers is a critical component of cancer-focused epidemiologic cohorts and of cancer prevention trials. Potential methods: for cancer case ascertainment include active follow-up and passive linkage with state cancer registries. Here we compare the two approaches in a large cancer screening trial. METHODS: The Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial enrolled 154,955 subjects at ten U.S. centers and followed them for all-cancer incidence...
December 2016: Cancer Epidemiology
https://www.readbyqxmd.com/read/27635065/the-prostate-lung-colorectal-and-ovarian-cancer-plco-screening-trial-pathology-tissue-resource
#13
Claire S Zhu, Wen-Yi Huang, Paul F Pinsky, Christine D Berg, Mark Sherman, Kelly J Yu, Danielle M Carrick, Amanda Black, Robert Hoover, Petra Lenz, Craig Williams, Laura Hawkins, Matthew Chaloux, Susan Yurgalevitch, Sunitha Mathew, Amy Miller, Vanessa Olivo, Asia Khan, Shannon M Pretzel, Deborah Multerer, Patricia Beckmann, Karen G Broski, Neal D Freedman
BACKGROUND: Pathology tissue specimens with associated epidemiologic and clinical data are valuable for cancer research. The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial undertook a large-scale effort to create a public resource of pathology tissues from PLCO participants who developed a cancer during the trial. METHODS: Formalin-fixed paraffin-embedded tissue blocks were obtained from pathology laboratories on a loan basis for central processing of tissue microarrays, with additional free-standing tissue cores collected for nucleic acid extraction...
December 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27628793/re-reevaluating-psa-testing-rates-in-the-plco-trial
#14
Samir S Taneja
No abstract text is available yet for this article.
October 2016: Journal of Urology
https://www.readbyqxmd.com/read/27615399/extended-mortality-results-for-ovarian-cancer-screening-in-the-plco-trial-with-median-15years-follow-up
#15
Paul F Pinsky, Kelly Yu, Barnett S Kramer, Amanda Black, Saundra S Buys, Edward Partridge, John Gohagan, Christine D Berg, Philip C Prorok
BACKGROUND: The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial originally reported no mortality benefit of ovarian cancer screening after a median of 12.4years of follow-up. The UKCTOCS screening trial failed to show a statistically significant mortality reduction in the primary analysis but reported an apparent increased mortality benefit in trial years 7-14 compared to 0-7. Here we report an updated analysis of PLCO with extended mortality follow-up. METHODS: Participants were randomized from 1993 to 2001 at ten U...
November 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27575906/the-current-state-of-prostate-specific-antigen-testing
#16
Ryan Lewis, Brad Hornberger
Since prostate-specific antigen (PSA) testing was approved in 1994, the incidence of metastasis and mortality from prostate cancer have significantly decreased. However, PSA screening for prostate cancer has limitations and few large randomized controlled trials have been conducted to determine the mortality benefit of PSA screening. Two studies that have been conducted are the Prostate, Lung, Colorectal, and Ovarian (PLCO) screening trial and the European Randomized Study of Screening for Prostate Cancer (ERSPC)...
September 2016: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/27569432/prognostic-significance-of-digital-rectal-examination-and-prostate-specific-antigen-in-the-prostate-lung-colorectal-and-ovarian-cancer-screening-arm
#17
Joshua A Halpern, Jonathan E Shoag, Sameer Mittal, Clara Oromendia, Karla V Ballman, Dawn L Hershman, Jason D Wright, Ya-Chen Tina Shih, Paul L Nguyen, Jim C Hu
PURPOSE: The absence of definitive data or explicit guidelines regarding the use of digital rectal examination for prostate cancer screening may lead to confusion for physicians and patients alike. We evaluated the prognostic value of abnormal digital rectal examination and prostate specific antigen following the widespread dissemination of prostate specific antigen testing in the U.S. MATERIALS AND METHODS: Collectively, men comprising the screening arm of the PLCO Cancer Screening Trial who underwent digital rectal examination screening (35,350) were followed for 314,033 person-years...
August 26, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27557513/genetic-variants-of-genes-in-the-notch-signaling-pathway-predict-overall-survival-of-non-small-cell-lung-cancer-patients-in-the-plco-study
#18
Yinghui Xu, Yanru Wang, Hongliang Liu, Xiaozheng Kang, Wei Li, Qingyi Wei
The Notch signaling pathway has been shown to have biological significance and therapeutic application in non-small cell lung cancer (NSCLC). We hypothesize that genetic variants of genes in the Notch signaling pathway are associated with overall survival (OS) of NSCLC patients. To test this hypothesis, we performed multivariate Cox proportional hazards regression analysis to evaluate associations of 19,571 single nucleotide polymorphisms (SNPs) in 132 Notch pathway genes with OS of 1,185 NSCLC patients available from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial...
August 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/27495847/re-re-evaluating-psa-testing-rates-in-the-plco-trial
#19
Monique J Roobol
No abstract text is available yet for this article.
August 2, 2016: European Urology
https://www.readbyqxmd.com/read/27400667/prostate-cancer-why-the-prostate-arm-of-the-plco-trial-failed-and-what-it-has-taught-us
#20
Matthew R Cooperberg
No abstract text is available yet for this article.
August 2016: Nature Reviews. Urology
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