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https://www.readbyqxmd.com/read/28542201/data-sharing-in-clinical-trials-an-experience-with-two-large-cancer-screening-trials
#1
Claire S Zhu, Paul F Pinsky, James E Moler, Andrew Kukwa, Jerome Mabie, Joshua M Rathmell, Tom Riley, Philip C Prorok, Christine D Berg
Paul Pinsky of the US National Cancer Institute and colleagues describe the implementation and outcomes of web-based data sharing from the PLCO and NLST cancer screening trials.
May 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28510291/associations-between-rna-splicing-regulatory-variants-of-stemness-related-genes-and-racial-disparities-in-susceptibility-to-prostate-cancer
#2
Yanru Wang, Jennifer A Freedman, Hongliang Liu, Patricia G Moorman, Terry Hyslop, Daniel J George, Norman H Lee, Steven R Patierno, Qingyi Wei
Evidence suggests that cells with a stemness phenotype play a pivotal role in oncogenesis, and prostate cells exhibiting this phenotype have been identified. We used two genome-wide association study (GWAS) datasets of African descendants, from the Multiethnic/Minority Cohort Study of Diet and Cancer (MEC) and the Ghana Prostate Study, and two GWAS datasets of non-Hispanic whites, from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial and the Breast and Prostate Cancer Cohort Consortium (BPC3), to analyze the associations between genetic variants of stemness-related genes and racial disparities in susceptibility to prostate cancer...
May 16, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28507039/do-aspirin-and-other-nsaids-confer-a-survival-benefit-in-men-diagnosed-with-prostate-cancer-a-pooled-analysis-of-nih-aarp-and-plco-cohorts
#3
Cindy Ke Zhou, Sarah E Daugherty, Linda M Liao, Neal D Freedman, Christian C Abnet, Ruth Pfeiffer, Michael B Cook
Prostate cancer is one of the leading causes of cancer-related death in U.S. men. There is an unmet need to identify modifiable risk factors for prostate cancer survival. Experimental studies have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) may improve prostate cancer survival through antithrombotic and anti-inflammation mechanisms. Results from previous observational studies have been equivocal, and few have assessed whether an etiologically relevant time window of exposure exists. We sampled incident prostate cancer cases from two large U...
May 15, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28484923/circulating-levels-of-obesity-related-markers-and-risk-of-renal-cell-carcinoma-in-the-plco-cancer-screening-trial
#4
Linda M Liao, Jonathan N Hofmann, Eunyoung Cho, Michael N Pollak, Wong-Ho Chow, Mark P Purdue
PURPOSE: Obesity is an established risk factor for renal cell carcinoma (RCC). It is unclear what biologic mechanisms underlie this association, although recent evidence suggests that the effects of circulating hormones such as insulin-like growth factors (IGF) and adipokines may play a role. METHODS: To address this question, we conducted a nested case-control study of RCC (252 cases, 252 controls) within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial investigating associations with pre-diagnostic serum levels of total adiponectin, high-molecular-weight (HMW) adiponectin, IGF-1, IGF-binding protein-3 (IGFBP-3), and C-peptide...
May 8, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28376206/prediagnostic-body-mass-index-trajectories-in-relation-to-prostate-cancer-incidence-and-mortality-in-the-plco-cancer-screening-trial
#5
Scott P Kelly, Barry I Graubard, Gabriella Andreotti, Naji Younes, Sean D Cleary, Michael B Cook
Background: Evidence suggests that obesity in adulthood is associated with increased risk of "clinically significant" prostate cancer. However, studies of body mass index (BMI) across the adult life course and prostate cancer risks remain limited. Methods: In a prospective cohort of 69 873 men in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, we examined associations of prediagnostic BMI across the adult life course with risk of incident prostate cancer and fatal prostate cancer (prostate cancer-specific mortality)...
March 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28376197/kinetics-of-the-human-papillomavirus-type-16-e6-antibody-response-prior-to-oropharyngeal-cancer
#6
Aimée R Kreimer, Mattias Johansson, Elizabeth L Yanik, Hormuzd A Katki, David P Check, Krystle A Lang Kuhs, Martina Willhauck-Fleckenstein, Dana Holzinger, Allan Hildesheim, Ruth Pfeiffer, Craig Williams, Neal D Freedman, Wen-Yi Huang, Mark P Purdue, Angelika Michel, Michael Pawlita, Paul Brennan, Tim Waterboer
Background: In a European cohort, it was previously reported that 35% of oropharyngeal cancer (OPC) patients were human papillomavirus type-16 (HPV16) seropositive up to 10 years before diagnosis vs 0.6% of cancer-free controls. Here, we describe the kinetics of HPV16-E6 antibodies prior to OPC diagnosis. Methods: We used annual serial prediagnostic blood samples from the PLCO Cancer Screening Trial. Antibodies to HPV were initially assessed in prediagnostic blood drawn at study enrollment from 198 incident head and neck cancer patients (median years to cancer diagnosis = 6...
August 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28376164/germline-mutations-in-the-kallikrein-6-region-and-predisposition-for-aggressive-prostate-cancer
#7
Laurent Briollais, Hilmi Ozcelik, Jingxiong Xu, Maciej Kwiatkowski, Emilie Lalonde, Dorota H Sendorek, Neil E Fleshner, Franz Recker, Cynthia Kuk, Ekaterina Olkhov-Mitsel, Tristan Juvet, Ioannis Prassas, John Trachtenberg, Ants Toi, Michael Fraser, Theodorus van der Kwast, Robert G Bristow, Bharati Bapat, Eleftherios P Diamandis, Paul C Boutros, Alexandre R Zlotta
Background: There is a need for markers that can specifically identify individuals at increased risk of harboring aggressive forms of prostate cancer (PCa). Methods: We surveyed the Kallikrein ( KLK ) region ( KLK 1-15) for single-nucleotide polymorphisms (SNPs) associated with aggressive PCa (Gleason Score ≥ 8) in 1858 PCa patients. Discovery cohorts (Swiss arm of the European Randomized Study of Screening for PCa, n = 379; Toronto, Canada, n = 540) and a validation cohort (Prostate, Lung, Colorectal and Ovarian [PLCO] screening trial, n = 939) were analyzed...
April 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28376113/risk-prediction-models-for-selection-of-lung-cancer-screening-candidates-a-retrospective-validation-study
#8
Kevin Ten Haaf, Jihyoun Jeon, Martin C Tammemägi, Summer S Han, Chung Yin Kong, Sylvia K Plevritis, Eric J Feuer, Harry J de Koning, Ewout W Steyerberg, Rafael Meza
BACKGROUND: Selection of candidates for lung cancer screening based on individual risk has been proposed as an alternative to criteria based on age and cumulative smoking exposure (pack-years). Nine previously established risk models were assessed for their ability to identify those most likely to develop or die from lung cancer. All models considered age and various aspects of smoking exposure (smoking status, smoking duration, cigarettes per day, pack-years smoked, time since smoking cessation) as risk predictors...
April 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28357528/a-prospective-study-of-mitochondrial-dna-copy-number-and-the-risk-of-prostate-cancer
#9
RANDOMIZED CONTROLLED TRIAL
Amy Moore, Qing Lan, Jonathan N Hofmann, Chin-San Liu, Wen-Ling Cheng, Ta-Tsung Lin, Sonja I Berndt
PURPOSE: Evidence suggests that mitochondrial DNA (mtDNA) copy number increases in response to DNA damage. Increased mtDNA copy number has been observed in prostate cancer (PCa) cells, suggesting a role in PCa development, but this association has not yet been investigated prospectively. METHODS: We conducted a nested case-control study (793 cases and 790 controls) of men randomized to the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) to evaluate the association between pre-diagnosis mtDNA copy number, measured in peripheral blood leukocytes, and the risk of PCa...
June 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28345504/the-association-between-dietary-inflammatory-index-scores-and-the-prevalence-of-colorectal-adenoma
#10
Alyson Haslam, Sara Wagner Robb, James R Hébert, Hanwen Huang, Michael D Wirth, Nitin Shivappa, Mark H Ebell
OBJECTIVE: The Dietary Inflammatory Index (DII)TM, which was developed to characterize the inflammatory potential of a person's diet, has been shown to be associated with inflammatory conditions such as cancer. The present study aimed to investigate the association between DII scores and colorectal adenoma (CRA), a pre-cancerous condition. DESIGN: Responses to baseline dietary questionnaires were used calculate DII scores. In a cross-sectional study design, the association between DII scores and CRA prevalence was determined in men and women separately using logistic regression models...
June 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28260648/impact-of-freeze-thaw-cycles-on-circulating-inflammation-marker-measurements
#11
Wen-Yi Huang, Troy J Kemp, Ruth M Pfeiffer, Ligia A Pinto, Allan Hildesheim, Mark P Purdue
BACKGROUND: Circulating inflammation markers are being increasingly measured in prospective cohorts to investigate cancer etiology. However, it is unclear how the measurements are affected by the freeze-thaw cycles of the specimens prior to marker analysis. METHODS: We compared concentrations of 45 inflammation markers between paired serum vials of 55 participants in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial that have undergone one (T1), two (T2), and three (T3) freeze-thaw cycles at the time of assay...
March 2, 2017: Cytokine
https://www.readbyqxmd.com/read/28213188/children-with-adhd-and-symptoms-of-oppositional-defiant-disorder-improved-in-behavior-when-treated-with-methylphenidate-and-adjuvant-risperidone-though-weight-gain-was-also-observed-results-from-a-randomized-double-blind-placebo-controlled-clinical-trial
#12
Leila Jahangard, Shahrokh Akbarian, Mohammad Haghighi, Mohammad Ahmadpanah, Amir Keshavarzi, Hafez Bajoghli, Dena Sadeghi Bahmani, Edith Holsboer-Trachsler, Serge Brand
Children with ADHD often show symptoms of oppositional defiant disorders (ODD). We investigated the impact of adjuvant risperidone (RISP) to a standard treatment with methylphenidate (MPH) in children with ADHD and symptoms of ODD. Eighty-four children with ADHD and ODD (age: M=8.55; range: 7.28-9.95 years; 73.8% males) took part in a double-blind, randomized, placebo-controlled, clinical trial lasting eight weeks. Participants were randomly assigned either to the MPH+RISP (1mg/kg/d+0.5mg/d) or to the MPH+PLCO (1mg/kg/d+placebo) condition...
May 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28196067/body-weight-trajectories-and-risk-of-oesophageal-and-gastric-cardia-adenocarcinomas-a-pooled-analysis-of-nih-aarp-and-plco-studies
#13
COMPARATIVE STUDY
Jessica L Petrick, Scott P Kelly, Linda M Liao, Neal D Freedman, Barry I Graubard, Michael B Cook
BACKGROUND: Elevated body mass index (BMI, kg m(-2)) has been consistently associated with oesophageal adenocarcinoma (EA) and gastric cardia adenocarcinoma (GCA) incidence. However, effects of adiposity over the life course in relation to EA/GCA have not been thoroughly explored. METHODS: We pooled two prospective cohort studies: NIH-AARP Diet and Health Study and Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, with data on 409 796 individuals (633 EA, 415 GCA)...
March 28, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28087510/effectiveness-of-flexible-sigmoidoscopy-screening-in-men-and-women-and-different-age-groups-pooled-analysis-of-randomised-trials
#14
Øyvind Holme, Robert E Schoen, Carlo Senore, Nereo Segnan, Geir Hoff, Magnus Løberg, Michael Bretthauer, Hans-Olov Adami, Mette Kalager
OBJECTIVE:  To compare the effectiveness of flexible sigmoidoscopy in screening for colorectal cancer by patient sex and age. DESIGN:  Pooled analysis of randomised trials (the US Prostate, Lung, Colorectal and Ovarian cancer screening trial (PLCO), the Italian Screening for Colon and Rectum trial (SCORE), and the Norwegian Colorectal Cancer Prevention trial (NORCCAP)). DATA SOURCES:  Aggregated data were pooled from each randomised trial on incidence of colorectal cancer and mortality stratified by sex, age at screening, and colon subsite (distal v proximal)...
January 13, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27911486/extended-mortality-results-for-prostate-cancer-screening-in-the-plco-trial-with-median-follow-up-of-15-years
#15
RANDOMIZED CONTROLLED TRIAL
Paul F Pinsky, Philip C Prorok, Kelly Yu, Barnett S Kramer, Amanda Black, John K Gohagan, E David Crawford, Robert L Grubb, Gerald L Andriole
BACKGROUND: Two large-scale prostate cancer screening trials using prostate-specific antigen (PSA) have given conflicting results in terms of the efficacy of such screening. One of those trials, the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, previously reported outcomes with 13 years of follow-up. This study presents updated findings from the PLCO trial. METHODS: The PLCO trial randomized subjects from 1993 to 2001 to an intervention or control arm...
February 15, 2017: Cancer
https://www.readbyqxmd.com/read/27906455/insights-from-the-plco-trial-about-prostate-cancer-screening
#16
EDITORIAL
Roman Gulati, Peter C Albertsen
No abstract text is available yet for this article.
February 15, 2017: Cancer
https://www.readbyqxmd.com/read/27845108/re-lethal-prostate-cancer-in-the-plco-cancer-screening-trial
#17
Samir S Taneja
No abstract text is available yet for this article.
December 2016: Journal of Urology
https://www.readbyqxmd.com/read/27837443/do-cancer-survivors-develop-healthier-lifestyle-behaviors-than-the-cancer-free-population-in-the-plco-study
#18
Makenzie L Hawkins, Saundra S Buys, Lisa H Gren, Sara E Simonsen, Anne C Kirchhoff, Mia Hashibe
BACKGROUND: Current studies report mixed results in health status and health behaviors after a diagnosis of cancer. The aim of our study is to investigate potential differences in lifestyle factors among cancer survivors and cancer-free individuals in a prospective cohort study conducted in the United States. METHODS: Using data from the Prostate, Lung, Colorectal and Ovarian (PLCO) Trial, 10,133 cancer survivors were identified and compared to 81,992 participants without cancer to evaluate differences in body mass index (BMI), smoking, NSAID use, and physical activity...
April 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/27823819/re-reevaluating-psa-testing-rates-in-the-plco-trial
#19
Peter Albers
No abstract text is available yet for this article.
February 2017: European Urology
https://www.readbyqxmd.com/read/27810449/detection-of-high-grade-prostate-cancer-among-plco-participants-using-a-prespecified-4-kallikrein-marker-panel
#20
Eric H Kim, Gerald L Andriole, E David Crawford, Daniel D Sjoberg, Melissa Assel, Andrew J Vickers, Hans Lilja
PURPOSE: We assessed the performance of a 4-kallikrein panel with and without microseminoprotein-β to predict high grade (Gleason 7+/Gleason Grade Group 2+) prostate cancer on biopsy in a multiethnic cohort from PLCO (Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial). MATERIALS AND METHODS: Levels of free, intact, total prostate specific antigen, human kallikrein-2 and microseminoprotein-β were measured while blinded to outcomes in cryopreserved serum from men in the intervention arm of PLCO...
April 2017: Journal of Urology
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