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https://www.readbyqxmd.com/read/28702814/evaluating-the-impact-of-varied-compliance-to-lung-cancer-screening-recommendations-using-a-microsimulation-model
#1
Summer S Han, S Ayca Erdogan, Iakovos Toumazis, Ann Leung, Sylvia K Plevritis
BACKGROUND: The US preventive services task force (USPSTF) recently recommended that individuals aged 55-80 with heavy smoking history be annually screened by low-dose computed tomography (LDCT), thereby extending the stopping age from 74 to 80 compared to the national lung screening trial (NLST) entry criterion. This decision was made partly with model-based analyses from cancer intervention and surveillance modeling network (CISNET), which assumed perfect compliance to screening. METHODS: As part of CISNET, we developed a microsimulation model for lung cancer (LC) screening and calibrated and validated it using data from NLST and the prostate, lung, colorectal, and ovarian cancer screening trial (PLCO), respectively...
July 12, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28699174/inherited-variation-in-circadian-rhythm-genes-and-risks-of-prostate-cancer-and-three-other-cancer-sites-in-combined-cancer-consortia
#2
Fangyi Gu, Han Zhang, Paula L Hyland, Sonja Berndt, Susan M Gapstur, William Wheeler, Christopher I Amos, Stephane Bezieau, Heike Bickeböller, Hermann Brenner, Paul Brennan, Jenny Chang-Claude, David V Conti, Jennifer Ann Doherty, Stephen B Gruber, Tabitha A Harrison, Richard B Hayes, Michael Hoffmeister, Richard S Houlston, Rayjean J Hung, Mark A Jenkins, Peter Kraft, Kate Lawrenson, James McKay, Sarah Markt, Lorelei Mucci, Catherine M Phelan, Conghui Qu, Angela Risch, Mary Anne Rossing, H-Erich Wichmann, Jianxin Shi, Eva Schernhammer, Kai Yu, Maria Teresa Landi, Neil E Caporaso
Circadian disruption has been linked to carcinogenesis in animal models, but the evidence in humans is inconclusive. Genetic variation in circadian rhythm genes provides a tool to investigate such associations. We examined associations of genetic variation in nine core circadian rhythm genes and six melatonin pathway genes with risk of colorectal, lung, ovarian and prostate cancers using data from the Genetic Associations and Mechanisms in Oncology (GAME-ON) network. The major results for prostate cancer were replicated in the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial, and for colorectal cancer in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO)...
July 12, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28694742/clinical-validation-of-a-blood-based-classifier-for-diagnostic-evaluation-of-asymptomatic-individuals-with-pulmonary-nodules
#3
Charles E Birse, Jennifer L Tomic, Harvey I Pass, William N Rom, Robert J Lagier
BACKGROUND: The number of pulmonary nodules detected in the US is expected to increase substantially following recent recommendations for nationwide CT-based lung cancer screening. Given the low specificity of CT screening, non-invasive adjuvant methods are needed to differentiate cancerous lesions from benign nodules to help avoid unnecessary invasive procedures in the asymptomatic population. We have constructed a serum-based multi-biomarker panel and assessed its clinical accuracy in a retrospective analysis of samples collected from participants with suspicious radiographic findings in the Prostate, Lung, Chest and Ovarian (PLCO) cancer screening trial...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/28681154/prediagnosis-circulating-insulin-like-growth-factors-and-pancreatic-cancer-survival
#4
Adetunji T Toriola, Mark Ziegler, Yize Li, Michael Pollak, Rachael Stolzenberg-Solomon
BACKGROUND: Prediagnosis obesity and diabetes are associated with survival from pancreatic cancer, but the underlying mechanisms have not been characterized. Because both are associated with dysregulation in circulating insulin-like growth factor (IGF) levels, we evaluated the associations of prediagnosis IGF levels (IGF-I, IGF-II) and IGF binding protein 3 (IGFBP-3) with pancreatic cancer survival. METHODS: Participants were subjects enrolled in the intervention arm of the PLCO Cancer Screening Trial who developed exocrine pancreatic cancer during follow-up (N = 178, 116 men and 67 women)...
July 5, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28669054/trichomonas-vaginalis-infection-and-risk-of-prostate-cancer-associations-by-disease-aggressiveness-and-race-ethnicity-in-the-plco-trial
#5
Miguelle Marous, Wen-Yi Huang, Charles S Rabkin, Richard B Hayes, John F Alderete, Bernard Rosner, Robert L Grubb, Anke C Winter, Siobhan Sutcliffe
PURPOSE: Results from previous sero-epidemiologic studies of Trichomonas vaginalis infection and prostate cancer (PCa) support a positive association between this sexually transmitted infection and aggressive PCa. However, findings from previous studies are not entirely consistent, and only one has investigated the possible relation between T. vaginalis seropositivity and PCa in African-American men who are at highest risk of both infection and PCa. Therefore, we examined this possible relation in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, including separate analyses for aggressive PCa and African-American men...
July 1, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28659298/nutritional-metabolomics-and-breast-cancer-risk-in-a-prospective-study
#6
Mary C Playdon, Regina G Ziegler, Joshua N Sampson, Rachael Stolzenberg-Solomon, Henry J Thompson, Melinda L Irwin, Susan T Mayne, Robert N Hoover, Steven C Moore
Background: The epidemiologic evidence for associations between dietary factors and breast cancer is weak and etiologic mechanisms are often unclear. Exploring the role of dietary biomarkers with metabolomics can potentially facilitate objective dietary characterization, mitigate errors related to self-reported diet, agnostically test metabolic pathways, and identify mechanistic mediators.Objective: The aim of this study was to evaluate associations of diet-related metabolites with the risk of breast cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial...
June 28, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28542201/data-sharing-in-clinical-trials-an-experience-with-two-large-cancer-screening-trials
#7
Claire S Zhu, Paul F Pinsky, James E Moler, Andrew Kukwa, Jerome Mabie, Joshua M Rathmell, Tom Riley, Philip C Prorok, Christine D Berg
Paul Pinsky of the US National Cancer Institute and colleagues describe the implementation and outcomes of web-based data sharing from the PLCO and NLST cancer screening trials.
May 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28510291/associations-between-rna-splicing-regulatory-variants-of-stemness-related-genes-and-racial-disparities-in-susceptibility-to-prostate-cancer
#8
Yanru Wang, Jennifer A Freedman, Hongliang Liu, Patricia G Moorman, Terry Hyslop, Daniel J George, Norman H Lee, Steven R Patierno, Qingyi Wei
Evidence suggests that cells with a stemness phenotype play a pivotal role in oncogenesis, and prostate cells exhibiting this phenotype have been identified. We used two genome-wide association study (GWAS) datasets of African descendants, from the Multiethnic/Minority Cohort Study of Diet and Cancer (MEC) and the Ghana Prostate Study, and two GWAS datasets of non-Hispanic whites, from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial and the Breast and Prostate Cancer Cohort Consortium (BPC3), to analyze the associations between genetic variants of stemness-related genes and racial disparities in susceptibility to prostate cancer...
August 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28507039/do-aspirin-and-other-nsaids-confer-a-survival-benefit-in-men-diagnosed-with-prostate-cancer-a-pooled-analysis-of-nih-aarp-and-plco-cohorts
#9
Cindy Ke Zhou, Sarah E Daugherty, Linda M Liao, Neal D Freedman, Christian C Abnet, Ruth Pfeiffer, Michael B Cook
Prostate cancer is one of the leading causes of cancer-related death in U.S. men. There is an unmet need to identify modifiable risk factors for prostate cancer survival. Experimental studies have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) may improve prostate cancer survival through antithrombotic and anti-inflammation mechanisms. Results from previous observational studies have been equivocal, and few have assessed whether an etiologically relevant time window of exposure exists. We sampled incident prostate cancer cases from two large U...
July 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28484923/circulating-levels-of-obesity-related-markers-and-risk-of-renal-cell-carcinoma-in-the-plco-cancer-screening-trial
#10
Linda M Liao, Jonathan N Hofmann, Eunyoung Cho, Michael N Pollak, Wong-Ho Chow, Mark P Purdue
PURPOSE: Obesity is an established risk factor for renal cell carcinoma (RCC). It is unclear what biologic mechanisms underlie this association, although recent evidence suggests that the effects of circulating hormones such as insulin-like growth factors (IGF) and adipokines may play a role. METHODS: To address this question, we conducted a nested case-control study of RCC (252 cases, 252 controls) within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial investigating associations with pre-diagnostic serum levels of total adiponectin, high-molecular-weight (HMW) adiponectin, IGF-1, IGF-binding protein-3 (IGFBP-3), and C-peptide...
July 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28376206/prediagnostic-body-mass-index-trajectories-in-relation-to-prostate-cancer-incidence-and-mortality-in-the-plco-cancer-screening-trial
#11
Scott P Kelly, Barry I Graubard, Gabriella Andreotti, Naji Younes, Sean D Cleary, Michael B Cook
Background: Evidence suggests that obesity in adulthood is associated with increased risk of "clinically significant" prostate cancer. However, studies of body mass index (BMI) across the adult life course and prostate cancer risks remain limited. Methods: In a prospective cohort of 69 873 men in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, we examined associations of prediagnostic BMI across the adult life course with risk of incident prostate cancer and fatal prostate cancer (prostate cancer-specific mortality)...
March 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28376197/kinetics-of-the-human-papillomavirus-type-16-e6-antibody-response-prior-to-oropharyngeal-cancer
#12
Aimée R Kreimer, Mattias Johansson, Elizabeth L Yanik, Hormuzd A Katki, David P Check, Krystle A Lang Kuhs, Martina Willhauck-Fleckenstein, Dana Holzinger, Allan Hildesheim, Ruth Pfeiffer, Craig Williams, Neal D Freedman, Wen-Yi Huang, Mark P Purdue, Angelika Michel, Michael Pawlita, Paul Brennan, Tim Waterboer
Background: In a European cohort, it was previously reported that 35% of oropharyngeal cancer (OPC) patients were human papillomavirus type-16 (HPV16) seropositive up to 10 years before diagnosis vs 0.6% of cancer-free controls. Here, we describe the kinetics of HPV16-E6 antibodies prior to OPC diagnosis. Methods: We used annual serial prediagnostic blood samples from the PLCO Cancer Screening Trial. Antibodies to HPV were initially assessed in prediagnostic blood drawn at study enrollment from 198 incident head and neck cancer patients (median years to cancer diagnosis = 6...
August 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28376164/germline-mutations-in-the-kallikrein-6-region-and-predisposition-for-aggressive-prostate-cancer
#13
Laurent Briollais, Hilmi Ozcelik, Jingxiong Xu, Maciej Kwiatkowski, Emilie Lalonde, Dorota H Sendorek, Neil E Fleshner, Franz Recker, Cynthia Kuk, Ekaterina Olkhov-Mitsel, Tristan Juvet, Ioannis Prassas, John Trachtenberg, Ants Toi, Michael Fraser, Theodorus van der Kwast, Robert G Bristow, Bharati Bapat, Eleftherios P Diamandis, Paul C Boutros, Alexandre R Zlotta, Yu-Jia Shiah, Antoninus Soosaipillai, Marco Randazzo, Karen Chadwick, Hong Li, Matt Friedlander, Geoffrey A Hunter, Sally Hanna, Sevtap Savas
Background: There is a need for markers that can specifically identify individuals at increased risk of harboring aggressive forms of prostate cancer (PCa). Methods: We surveyed the Kallikrein ( KLK ) region ( KLK 1-15) for single-nucleotide polymorphisms (SNPs) associated with aggressive PCa (Gleason Score ≥ 8) in 1858 PCa patients. Discovery cohorts (Swiss arm of the European Randomized Study of Screening for PCa, n = 379; Toronto, Canada, n = 540) and a validation cohort (Prostate, Lung, Colorectal and Ovarian [PLCO] screening trial, n = 939) were analyzed...
April 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28376113/risk-prediction-models-for-selection-of-lung-cancer-screening-candidates-a-retrospective-validation-study
#14
Kevin Ten Haaf, Jihyoun Jeon, Martin C Tammemägi, Summer S Han, Chung Yin Kong, Sylvia K Plevritis, Eric J Feuer, Harry J de Koning, Ewout W Steyerberg, Rafael Meza
BACKGROUND: Selection of candidates for lung cancer screening based on individual risk has been proposed as an alternative to criteria based on age and cumulative smoking exposure (pack-years). Nine previously established risk models were assessed for their ability to identify those most likely to develop or die from lung cancer. All models considered age and various aspects of smoking exposure (smoking status, smoking duration, cigarettes per day, pack-years smoked, time since smoking cessation) as risk predictors...
April 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28357528/a-prospective-study-of-mitochondrial-dna-copy-number-and-the-risk-of-prostate-cancer
#15
RANDOMIZED CONTROLLED TRIAL
Amy Moore, Qing Lan, Jonathan N Hofmann, Chin-San Liu, Wen-Ling Cheng, Ta-Tsung Lin, Sonja I Berndt
PURPOSE: Evidence suggests that mitochondrial DNA (mtDNA) copy number increases in response to DNA damage. Increased mtDNA copy number has been observed in prostate cancer (PCa) cells, suggesting a role in PCa development, but this association has not yet been investigated prospectively. METHODS: We conducted a nested case-control study (793 cases and 790 controls) of men randomized to the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) to evaluate the association between pre-diagnosis mtDNA copy number, measured in peripheral blood leukocytes, and the risk of PCa...
June 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28345504/the-association-between-dietary-inflammatory-index-scores-and-the-prevalence-of-colorectal-adenoma
#16
Alyson Haslam, Sara Wagner Robb, James R Hébert, Hanwen Huang, Michael D Wirth, Nitin Shivappa, Mark H Ebell
OBJECTIVE: The Dietary Inflammatory Index (DII)TM, which was developed to characterize the inflammatory potential of a person's diet, has been shown to be associated with inflammatory conditions such as cancer. The present study aimed to investigate the association between DII scores and colorectal adenoma (CRA), a pre-cancerous condition. DESIGN: Responses to baseline dietary questionnaires were used calculate DII scores. In a cross-sectional study design, the association between DII scores and CRA prevalence was determined in men and women separately using logistic regression models...
June 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28260648/impact-of-freeze-thaw-cycles-on-circulating-inflammation-marker-measurements
#17
Wen-Yi Huang, Troy J Kemp, Ruth M Pfeiffer, Ligia A Pinto, Allan Hildesheim, Mark P Purdue
BACKGROUND: Circulating inflammation markers are being increasingly measured in prospective cohorts to investigate cancer etiology. However, it is unclear how the measurements are affected by the freeze-thaw cycles of the specimens prior to marker analysis. METHODS: We compared concentrations of 45 inflammation markers between paired serum vials of 55 participants in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial that have undergone one (T1), two (T2), and three (T3) freeze-thaw cycles at the time of assay...
March 2, 2017: Cytokine
https://www.readbyqxmd.com/read/28213188/children-with-adhd-and-symptoms-of-oppositional-defiant-disorder-improved-in-behavior-when-treated-with-methylphenidate-and-adjuvant-risperidone-though-weight-gain-was-also-observed-results-from-a-randomized-double-blind-placebo-controlled-clinical-trial
#18
Leila Jahangard, Shahrokh Akbarian, Mohammad Haghighi, Mohammad Ahmadpanah, Amir Keshavarzi, Hafez Bajoghli, Dena Sadeghi Bahmani, Edith Holsboer-Trachsler, Serge Brand
Children with ADHD often show symptoms of oppositional defiant disorders (ODD). We investigated the impact of adjuvant risperidone (RISP) to a standard treatment with methylphenidate (MPH) in children with ADHD and symptoms of ODD. Eighty-four children with ADHD and ODD (age: M=8.55; range: 7.28-9.95 years; 73.8% males) took part in a double-blind, randomized, placebo-controlled, clinical trial lasting eight weeks. Participants were randomly assigned either to the MPH+RISP (1mg/kg/d+0.5mg/d) or to the MPH+PLCO (1mg/kg/d+placebo) condition...
May 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28196067/body-weight-trajectories-and-risk-of-oesophageal-and-gastric-cardia-adenocarcinomas-a-pooled-analysis-of-nih-aarp-and-plco-studies
#19
COMPARATIVE STUDY
Jessica L Petrick, Scott P Kelly, Linda M Liao, Neal D Freedman, Barry I Graubard, Michael B Cook
BACKGROUND: Elevated body mass index (BMI, kg m(-2)) has been consistently associated with oesophageal adenocarcinoma (EA) and gastric cardia adenocarcinoma (GCA) incidence. However, effects of adiposity over the life course in relation to EA/GCA have not been thoroughly explored. METHODS: We pooled two prospective cohort studies: NIH-AARP Diet and Health Study and Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, with data on 409 796 individuals (633 EA, 415 GCA)...
March 28, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28087510/effectiveness-of-flexible-sigmoidoscopy-screening-in-men-and-women-and-different-age-groups-pooled-analysis-of-randomised-trials
#20
Øyvind Holme, Robert E Schoen, Carlo Senore, Nereo Segnan, Geir Hoff, Magnus Løberg, Michael Bretthauer, Hans-Olov Adami, Mette Kalager
OBJECTIVE:  To compare the effectiveness of flexible sigmoidoscopy in screening for colorectal cancer by patient sex and age. DESIGN:  Pooled analysis of randomised trials (the US Prostate, Lung, Colorectal and Ovarian cancer screening trial (PLCO), the Italian Screening for Colon and Rectum trial (SCORE), and the Norwegian Colorectal Cancer Prevention trial (NORCCAP)). DATA SOURCES:  Aggregated data were pooled from each randomised trial on incidence of colorectal cancer and mortality stratified by sex, age at screening, and colon subsite (distal v proximal)...
January 13, 2017: BMJ: British Medical Journal
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