keyword
https://read.qxmd.com/read/38534388/grafted-sertoli-cells-exert-immunomodulatory-non-immunosuppressive-effects-in-preclinical-models-of-infection-and-cancer
#1
JOURNAL ARTICLE
Sara Chiappalupi, Laura Salvadori, Monica Borghi, Francesca Mancuso, Marilena Pariano, Francesca Riuzzi, Giovanni Luca, Luigina Romani, Iva Arato, Guglielmo Sorci
The Sertoli cells (SeCs) of the seminiferous tubules secrete a multitude of immunoregulatory and trophic factors to provide immune protection and assist in the orderly development of germ cells. Grafts of naked or encapsulated SeCs have been proved to represent an interesting therapeutic option in a plethora of experimental models of diseases. However, whether SeCs have immunosuppressive or immunomodulatory effects, which is imperative for their clinical translatability, has not been demonstrated. We directly assessed the immunopotential of intraperitoneally grafted microencapsulated porcine SeCs (MC-SeCs) in murine models of fungal infection ( Aspergillus fumigatus or Candida albicans ) or cancer (Lewis lung carcinoma/LLC or B16 melanoma cells)...
March 19, 2024: Cells
https://read.qxmd.com/read/38534347/vitamin-d-in-cutaneous-t-cell-lymphoma
#2
REVIEW
August-Witte Feentved Ødum, Carsten Geisler
Cutaneous T-cell lymphoma (CTCL) is characterized by the proliferation of malignant T cells in inflamed skin lesions. Mycosis fungoides (MF)-the most common variant of CTCL-often presents with skin lesions around the abdomen and buttocks ("bathing suit" distribution), i.e., in skin areas devoid of sun-induced vitamin D. For decades, sunlight and vitamin D have been connected to CTCL. Thus, vitamin D induces apoptosis and inhibits the expression of cytokines in malignant T cells. Furthermore, CTCL patients often display vitamin D deficiency, whereas phototherapy induces vitamin D and has beneficial effects in CTCL, suggesting that light and vitamin D have beneficial/protective effects in CTCL...
March 13, 2024: Cells
https://read.qxmd.com/read/38530256/tolerogenic-cd11c-dendritic-cells-regulate-cd4-tregs-in-replacing-delayed-ischemic-preconditioning-to-alleviate-ischemia-reperfusion-acute-kidney-injury
#3
JOURNAL ARTICLE
Pingping Wang, Chunyao Li, Tao Peng, Longzhu Ruan, Aijie Wu, Jiaojiao Zhu, Wenlu Shi, Menghua Chen, Ting Zhang
Ischemia-reperfusion injury (IRI) is one of the primary clinical causes of acute kidney injury (AKI). The key to IRI lies in immune-inflammatory damage, where dendritic cells (DCs) play a central role in eliciting immune responses within the context of inflammation induced by ischemia-reperfusion. Our previous study has confirmed that delayed ischemic preconditioning (DIPC) can reduce the kidney injury by mediating DCs to regulate T-cells. However, the clinical feasibility of DIPC is limited, as pre-clamping of the renal artery is not applicable for the prevention and treatment of ischemia-reperfusion acute kidney injury (I/R-AKI) in clinical patients...
March 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38528553/extracorporeal-photopheresis-reduces-inflammation-and-joint-damage-in-a-rheumatoid-arthritis-murine-model
#4
JOURNAL ARTICLE
Yuwei Lin, Zhanrui Cheng, Yan Zhong, Yinting Zhao, Guifen Xiang, Ling Li, Li Tian, Zhong Liu
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammatory reactions and tissue damage in the joints. Long-term drug use in clinical practice is often accompanied by adverse reactions. Extracorporeal photopheresis (ECP) is an immunomodulatory therapy with few side effects, offering a potential and safe therapeutic alternative for RA through the induction of immune tolerance. This study aimed to investigate the therapeutic effects of ECP on RA using a collagen-induced arthritis (CIA) murine model, as well as to explore its immunomodulatory effects in vivo...
March 25, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38523030/advancing-immunosuppression-in-liver-transplantation-a-narrative-review
#5
REVIEW
Samuele Iesari, Francesca Laura Nava, Ilaria Elena Zais, Laurent Coubeau, Mariano Ferraresso, Evaldo Favi, Jan Lerut
Immunosuppression is essential to ensure recipient and graft survivals after liver transplantation (LT). However, our understanding and management of the immune system remain suboptimal. Current immunosuppressive therapy cannot selectively inhibit the graft-specific immune response and entails a significant risk of serious side effects, i.e., among others, de novo cancers, infections, cardiovascular events, renal failure, metabolic syndrome, and late graft fibrosis, with progressive loss of graft function. Pharmacological research, aimed to develop alternative immunosuppressive agents in LT, is behind other solid-organ transplantation subspecialties, and, therefore, the development of new compounds and strategies should get priority in LT...
March 16, 2024: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://read.qxmd.com/read/38521227/fecal-microbiota-transplantation-stimulates-type-2-and-tolerogenic-immune-responses-in-a-mouse-model
#6
JOURNAL ARTICLE
G Brett Moreau, Farha Naz, William A Petri
OBJECTIVES: Clostridioides difficile infection (CDI) is the leading hospital-acquired infection in North America. While previous work on fecal microbiota transplantation (FMT), a highly effective treatment for CDI, has focused on colonization resistance mounted against C. difficile by FMT-delivered commensals, the effects of FMT on host gene expression are relatively unexplored. This study aims to identify transcriptional changes associated with FMT, particularly changes associated with protective immune responses...
March 21, 2024: Anaerobe
https://read.qxmd.com/read/38515758/group-a-streptococcal-collagen-like-protein-1-restricts-tumor-growth-in-murine-pancreatic-adenocarcinoma-and-inhibits-cancer-promoting-neutrophil-extracellular-traps
#7
JOURNAL ARTICLE
Emily A Henderson, Abby Ivey, Soo Jeon Choi, Stell Santiago, Dudley McNitt, Tracy W Liu, Slawomir Lukomski, Brian A Boone
INTRODUCTION: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer associated with an immunosuppressive environment. Neutrophil extracellular traps (NETs) were initially described in the context of infection but have more recently been implicated in contributing to the tolerogenic immune response in PDAC. Thus, NETs are an attractive target for new therapeutic strategies. Group A Streptococcus (GAS) has developed defensive strategies to inhibit NETs. METHODS: In the present work, we propose utilizing intra-tumoral GAS injection to stimulate anti-tumor activity by inhibiting cancer-promoting NETs...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38515748/innovative-prognostic-modeling-in-escc-leveraging-scrna-seq-and-bulk-rna-for-dendritic-cell-heterogeneity-analysis
#8
JOURNAL ARTICLE
Mengnan Shi, Han Zhang, Linnan Ma, Xiaoting Wang, Daqiang Sun, Zhijie Feng
BACKGROUND: Globally, esophageal squamous cell carcinoma (ESCC) stands out as a common cancer type, characterized by its notably high rates of occurrence and mortality. Recent advancements in treatment methods, including immunotherapy, have shown promise, yet the prognosis remains poor. In the context of tumor development and treatment outcomes, the tumor microenvironment (TME), especially the function of dendritic cells (DCs), is significantly influential. Our study aims to delve deeper into the heterogeneity of DCs in ESCC using single-cell RNA sequencing (scRNA-seq) and bulk RNA analysis...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38513626/purified-free-mannan-promotes-tolerogenic-responses-in-peanut-stimulated-human-dendritic-cells
#9
Silvia Sánchez-Herrero, Cristina Benito-Villalvilla, Oscar Palomares
INTRODUCTION: IgE-mediated peanut allergy is an important public health problem of increasing prevalence leading to anaphylactic reactions both in children and adults. Allergen-specific oral immunotherapy (OIT) is the single treatment with the potential capacity to modify the course of the disease, but it still faces some drawbacks in terms of efficacy, safety, patients' adherence, and cost. Alternative strategies, including the use of novel adjuvants, to overcome such limitations are highly demanded...
March 21, 2024: International Archives of Allergy and Immunology
https://read.qxmd.com/read/38509733/tolerogenic-probiotics%C3%A2-lactobacillus-delbrueckii%C3%A2-and-lactobacillus-rhamnosus-promote-anti-inflammatory-profile-of-macrophages-derived-monocytes-of-newly-diagnosed-patients-with-systemic-lupus-erythematosus
#10
JOURNAL ARTICLE
Zahra Javanmardi, Mahmoud Mahmoudi, Houshang Rafatpanah, Zahra Rezaieyazdi, Abbas Shapouri-Moghaddam, Parisa Ahmadi, Samaneh Mollazadeh, Nafiseh Sadat Tabasi, Seyed-Alireza Esmaeili
Systemic lupus erythematosus (SLE) is known as an autoimmune disorder that is characterized by the breakdown of self-tolerance, resulting in disease onset and progression. Macrophages have been implicated as a factor in the development of SLE through faulty phagocytosis of dead cells or an imbalanced M1/M2 ratio. The study aimed to investigate the immunomodulatory effects of Lactobacillus delbrueckii and Lactobacillus rhamnosus on M1 and M2 macrophages in new case lupus patients. For this purpose, blood monocytes were collected from lupus patients and healthy people and were cultured for 5 days to produce macrophages...
March 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38509264/a-microbially-produced-ahr-ligand-promotes-a-tph1-driven-tolerogenic-program-in-multiple-sclerosis
#11
JOURNAL ARTICLE
Teresa Zelante, Giuseppe Paolicelli, Francesca Fallarino, Marco Gargaro, Gianluca Vascelli, Marco De Zuani, Jan Fric, Petra Laznickova, Marcela Hortova Kohoutkova, Antonio Macchiarulo, Daniela Dolciami, Giuseppe Pieraccini, Lorenzo Gaetani, Giulia Scalisi, Caterina Trevisan, Barbara Frossi, Carlo Pucillo, Antonella De Luca, Emilia Nunzi, Roberta Spaccapelo, Marilena Pariano, Monica Borghi, Francesca Boscaro, Riccardo Romoli, Andrea Mancini, Lucia Gentili, Giorgia Renga, Claudio Costantini, Matteo Puccetti, Stefano Giovagnoli, Maurizio Ricci, Martina Antonini, Paolo Calabresi, Paolo Puccetti, Massimiliano Di Filippo, Luigina Romani
Multiple sclerosis is a debilitating autoimmune disease, characterized by chronic inflammation of the central nervous system. While the significance of the gut microbiome on multiple sclerosis pathogenesis is established, the underlining mechanisms are unknown. We found that serum levels of the microbial postbiotic tryptophan metabolite indole-3-carboxaldehyde (3-IAld) inversely correlated with disease duration in multiple sclerosis patients. Much like the host-derived tryptophan derivative L-Kynurenine, 3-IAld would bind and activate the Aryl hydrocarbon Receptor (AhR), which, in turn, controls endogenous tryptophan catabolic pathways...
March 20, 2024: Scientific Reports
https://read.qxmd.com/read/38505675/introduction-of-a-new-recombinant-vaccine-based-on-grp78-for-breast-cancer-immunotherapy-and-evaluation-in-a-mouse-model
#12
JOURNAL ARTICLE
Hamed Zare, Hamid Bakherad, Arman Nasr Esfahani, Mohamad Norouzi, Hossein Aghamollaei, Seyed Latif Mousavi Gargari, Fatemeh Mahmoodi, Mahdi Aliomrani, Walead Ebrahimizadeh
INTRODUCTION: Breast cancer is one of the most prevalent malignancies in women. Several treatment options are available today, including surgery, chemotherapy, and radiotherapy. Immunotherapy, as a highly specific therapy, involves adaptive immune responses and immunological memory. In our present research, we used the recombinant C-terminal domain of the GRP78 (glucose- regulated protein 78) protein to induce an immune response and investigate its therapeutic impact in the 4T1 breast cancer model...
2024: BioImpacts: BI
https://read.qxmd.com/read/38496417/beta-cells-deficient-for-renalase-counteract-autoimmunity-by-shaping-natural-killer-cell-activity
#13
Kevin Bode, Siying Wei, Isabella Gruber, Stephan Kissler, Peng Yi
Type 1 diabetes (T1D) arises from autoimmune-mediated destruction of insulin-producing pancreatic beta cells. Recent advancements in the technology of generating pancreatic beta cells from human pluripotent stem cells (SC-beta cells) have facilitated the exploration of cell replacement therapies for treating T1D. However, the persistent threat of autoimmunity poses a significant challenge to the survival of transplanted SC-beta cells. Genetic engineering is a promising approach to enhance immune resistance of beta cells as we previously showed by inactivating of the Renalase ( Rnls ) gene...
March 4, 2024: bioRxiv
https://read.qxmd.com/read/38492186/immunomodulatory-and-anti-inflammatory-effects-of-vitamin-a-and-tryptophan-on-monocyte-derived-dendritic-cells-stimulated-with-gliadin-in-celiac-disease-patients
#14
JOURNAL ARTICLE
Fatemeh Asgari, Abdolrahim Nikzamir, Kaveh Baghaei, Siamak Salami, Andrea Masotti, Mohammad Rostami-Nejad
Celiac Disease (CeD) is an autoimmune disorder with various symptoms upon gluten exposure. Dendritic cells (DCs) play a crucial role in gliadin-induced inflammation. Vitamin A (retinol; Ret) and its metabolite, retinoic acid (RA), along with tryptophan (Trp) and its metabolite, kynurenic acid (KYNA), are known to influence the immune function of DCs and enhance their tolerogenicity. This research aims to assess the impact of gliadin on DC maturation and the potential of vitamin A and tryptophan to induce immune tolerance in DCs...
March 16, 2024: Inflammation
https://read.qxmd.com/read/38485600/dendritic-cells-and-antigen-specific-immunotherapy-in-autoimmune-rheumatic-diseases
#15
REVIEW
Benjamin Cai, Ranjeny Thomas
Dendritic cells (DCs) are professional antigen-presenting cells and trigger downstream immune responses to antigen while integrating cellular pathogen and damage-associated molecular pattern (PAMP and DAMP) or immunomodulatory signals. In healthy individuals, resting and tolerogenic DCs draining skin and intestine facilitate expansion of regulatory T cells (Treg) to maintain peripheral antigen-specific immune tolerance. In patients with rheumatic diseases, however, DCs activated by PAMPs and DAMPs expand self-reactive effector T cells, including follicular helper T cells that promote the expansion of activated autoreactive B cells, chronic inflammation and end-organ damage...
March 13, 2024: Best Practice & Research. Clinical Rheumatology
https://read.qxmd.com/read/38467375/immunosuppression-withdrawal-in-living-donor-renal-transplant-recipients-following-induction-with-anti-thymocyte-globulin-and-rituximab-results-of-a-prospective-clinical-trial
#16
JOURNAL ARTICLE
James F Markmann, Bryna E Burrell, Jonathan S Bromberg, Choli Hartono, Dixon B Kaufman, Andrew M Possselt, Ali Naji, Nancy D Bridges, Cynthia Breeden, Sai Kanaparthi, Jorge Pardo, Heather Kopetskie, Kristen Mason, Noha Lim, Sindhu Chandran
Durable tolerance in kidney transplant recipients remains an important but elusive goal. We hypothesized that adding B cell depletion to T cell depletion would generate an immune milieu post-reconstitution dominated by immature transitional B cells, favoring tolerance. The Immune Tolerance Network ITN039ST RESTARRT was a prospective multicenter pilot study of live donor kidney transplant recipients who received induction with rabbit anti-thymocyte globulin and rituximab, and initiated immunosuppression withdrawal (ISW) at 26 weeks...
March 9, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38460658/role-of-sulfatide-reactive-vnkt-cells-in-promoting-lung-treg-cells-via-dendritic-cell-modulation-in-asthma-models
#17
JOURNAL ARTICLE
Haiyang Ni, Qibin Lin, Jieying Zhong, Shaoding Gan, Hong Cheng, Yi Huang, Xuhong Ding, Hongying Yu, Yaqing Xu, Hanxiang Nie
Our previous studies have showed that sulfatide-reactive type II NKT (i.e. variant NKT, vNKT) cells inhibit the immunogenic maturation during the development of mature lung dendritic cells (LDCs), leading todeclined allergic airway inflammation in asthma. Nonetheless, the specific immunoregulatory roles of vNKT cells in LDC-mediated Th2 cell responses remain incompletely understood. Herein, we found that administration of sulfatide facilitated the generation of CD4+ FoxP3+ regulatory T (Treg) cells in the lungs of wild-type mice, but not in CD1d-/- and Jα18-/- mice, after ovalbumin or house dust mite exposure...
March 7, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38458075/targeting-macrophages-with-phosphatidylserine-rich-liposomes-as-a-potential-antigen-specific-immunotherapy-for-type-1-diabetes
#18
JOURNAL ARTICLE
Ivan Garcia-Loza, David Perna-Barrull, Eva Aguilera, Lidia Almenara-Fuentes, Laia Gomez-Muñoz, Daniela Greco, Maria Vila, Miriam Salvado, Montserrat Mancera-Arteu, Michael W Olszowy, Jordi Petriz, Marti Dalmases, Silvia Rodriguez-Vidal, Bruna Barneda-Zahonero, Marta Vives-Pi
Type 1 diabetes (T1D) results from a breakdown in immunological tolerance, with pivotal involvement of antigen-presenting cells. In this context, antigen-specific immunotherapies have been developed to arrest autoimmunity, such as phosphatidylserine (PS)-liposomes. However, the role of certain antigen-presenting cells in immunotherapy, particularly human macrophages (Mφ) in T1D remains elusive. The aim of this study was to determine the role of Mφ in antigen-specific immune tolerance and T1D. To that end, we evaluated Mφ ability to capture apoptotic-body mimicking PS-liposomes in mice and conducted a phenotypic and functional characterisation of four human monocyte-derived Mφ (MoMφ) subpopulations (M0, M1, M2a and M2c) after PS-liposomes uptake...
March 7, 2024: Journal of Autoimmunity
https://read.qxmd.com/read/38452440/cd4-%C3%A2-foxp3-%C3%A2-regulatory-t-cells-in-modulating-inflammatory-microenvironment-in-chronic-rhinosinusitis-with-nasal-polyps-progress-and-future-prospect
#19
REVIEW
Nur Najwa Farahin M Yusoff, Suhana Ahmad, Wan Faiziah Wan Abdul Rahman, Rohimah Mohamud, Jennifer C Boer, Magdalena Plebanski, Baharudin Abdullah, Xin Chen, Tengku Ahmad Damitri Al-Astani Tengku Din
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a subtype of chronic rhinosinusitis (CRS) characterized by the presence of nasal polyps (NP) in the paranasal mucosa. Despite the complex etiology, NP is believed to result from chronic inflammation. The long-term aftermath of the type 2 response is responsible for symptoms seen in NP patients, i.e. rhinorrhea, hyposmia, and nasal obstruction. Immune cellular tolerogenic mechanisms, particularly CD4 + Foxp3 + regulatory T cells (Tregs), are crucial to curtail inflammatory responses...
March 6, 2024: Cytokine
https://read.qxmd.com/read/38452413/tolerogenic-dendritic-cells-alleviate-collagen-induced-arthritis-by-regulating-t-cell-differentiation-and-inhibiting-nlrp3-mediated-apoptosis
#20
JOURNAL ARTICLE
Rui Yuan, Xiufang Wan, Lunmin Bao, Tiaoyu Long, Honghong Li, Yan Zhou, Lian Liu, Ping Shi, Rui Gong, Hongmei Jiang
OBJECTIVE: Tolerogenic dendritic cells (tolDCs) have emerged as a potential treatment for rheumatoid arthritis (RA). However, the detailed mechanism requires further investigation. In this study, we aimed to explore the effects of tolDCs on T-cell differentiation and NLRP3-mediated pyroptosis in a collagen-induced arthritis (CIA) rat model. METHODS: TolDCs were induced using NF-κB ODN decoy. The efficacy of tolDCs intervention in alleviating arthritis symptoms was evaluated in CIA rats...
March 6, 2024: International Immunopharmacology
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