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https://www.readbyqxmd.com/read/29151560/-structural-equation-modeling-on-health-related-quality-of-life-in-adults-with-epilepsy
#1
Jeong Ok Ko, Myung Ha Lee
PURPOSE: This study aimed to identify variables influencing the health-related quality of life (HRQoL) of adults with epilepsy in order to establish a structural model and design an intervention strategy to improve patients' HRQoL. METHODS: The selected subjects were 212 patients with epilepsy aged between 18 and 70 years who were currently receiving treatment from hospital, general hospital, and clinic. They were surveyed using a structured questionnaire. RESULTS: The goodness of fit measures of the final hypothetical model were as follows: χ²/df=2...
October 2017: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/29129776/glucagon-like-peptide-1-glp-1-and-neurotransmitters-signaling-in-epilepsy-an-insight-review
#2
REVIEW
Prashant Koshal, Sumit Jamwal, Puneet Kumar
Epilepsy is one of the most prevalent neurological disorder affecting more than 50 million people worldwide. Numerous studies have suggested that an imbalance in glutamatergic (excitatory) and GABAergic (inhibitory) neurotransmitter system is one of the dominating pathophysiological mechanisms underlying the occurrence and progression of seizures. Further, this alteration in GABAergic and glutamatergic system disrupts the delicate balance of other neurotransmitters system in the brain. Emerging strides have documented the protective role of GLP-1 signaling on altered neurotransmitters signaling in Epilepsy and associated co-morbidities...
November 9, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29122649/the-impact-of-global-hemodynamics-oxygen-and-carbon-dioxide-on-epileptiform-eeg-activity-in-comatose-survivors-of-out-of-hospital-cardiac-arrest
#3
C Moonen, R Lemmens, W Van Paesschen, A Wilmer, W Eertmans, B Ferdinande, M Dupont, C De Deyne, J Dens, S Janssens, K Ameloot
AIM: To study the association between global hemodynamics, blood gases, epileptiform EEG activity and survival after out-of-hospital CA (0HCA). METHODS: We retrospectively analyzed 195 comatose post-CA patients. At least one EEG recording per patient was evaluated to diagnose epileptiform EEG activity. Refractory epileptiform EEG activity was defined as persisting epileptic activity on EEG despite the use of 2 or more anti-epileptics. The time weighted average mean arterial pressure 48hours (TWA-MAP48), the percentage of time with a MAP below 65 and above 85mmHg and the percentage of time with normoxia, hypoxia (<70mmHg), hyperoxia (>150mmHg), normocapnia, hypocapnia (<35mmHg) and hypercapnia (>45mmHg) were calculated...
November 6, 2017: Resuscitation
https://www.readbyqxmd.com/read/29120264/treatment-options-for-chorea
#4
H Bashir, J Jankovic
Chorea is defined as jerk-like movements that move randomly from one body part to another. It is due to a variety of disorders and although current symptomatic therapy is quite effective there are few etiology- or pathogenesis-targeted therapies. The aim of this review is to summarize our own experience and published evidence in the treatment of chorea. Areas covered: After evaluating current guidelines and clinical practices for chorea of all etiologies, PubMed was searched for the most recent clinical trials and reviews using the term 'chorea' cross referenced with specific drug names...
November 9, 2017: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/29118737/a-case-series-of-adult-onset-rasmussen-s-encephalitis-diagnostic-and-therapeutic-challenges
#5
James Francis Castellano, Jenny A Meyer, Fred Alexander Lado
Rasmussen's encephalitis (RE) is a rare neurologic disorder characterized by progressive cerebral hemiatrophy and medically refractory epilepsy. The majority of current literature on this topic is focused on the pediatric population. In this case series, we will review three cases of adult-onset RE, as defined by fulfillment of the 2005 Bien criteria. The diagnostic challenge of characterizing this rare disease will be highlighted by the extensive serum, CSF, and pathologic sampling in all three patients. MR imaging and EEG data will be examined over time to characterize hallmark findings as well as progression...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29115760/efficacy-and-safety-of-cannabis-for-treating-children-with-refractory-epilepsy
#6
Michelle Neale
The aim of this literature review was to examine the evidence base for the safety and efficacy of cannabis in treating children with refractory epilepsy. Clinical and medical databases were searched and four articles were included in the final analysis, which included retrospective reviews and open-label trials with a total sample size of 424. One clinical trial included administration of cannabidiol, the non-psychoactive compound of cannabis, while the other three articles stated that the compound administered to participants contained tetrahydrocannabidiol, the psychoactive constituent of cannabis...
September 11, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/29114943/pharmacokinetics-of-single-oral-dose-extended-release-levetiracetam-in-healthy-cats
#7
L Barnard, H Barnes Heller, D M Boothe
BACKGROUND: Repeated PO dosing of anti-epileptic drugs may contribute to poor compliance in treated cats. Intermediate-release levetiracetam has been used safely in cats, but must be given q8h to maintain serum concentrations in the therapeutic interval for humans (5-45 μg/mL). Approved extended-release levetiracetam (XRL) for human use may require less frequent dosing, but the large dosing unit has limited its use in cats. HYPOTHESES: In healthy cats, serum levetiracetam concentration will remain above 5 μg/mL for at least 24 hours after administration of a single dose of XRL PO and will be well tolerated...
November 8, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29104528/the-effect-of-lamotrigine-and-levetiracetam-on-tms-evoked-eeg-responses-depends-on-stimulation-intensity
#8
Isabella Premoli, Alyssa Costantini, Davide Rivolta, Andrea Biondi, Mark P Richardson
The combination of transcranial magnetic stimulation and electroencephalography (TMS-EEG) has uncovered underlying mechanisms of two anti-epileptic medications: levetiracetam and lamotrigine. Despite their different mechanism of action, both drugs modulated TMS-evoked EEG potentials (TEPs) in a similar way. Since both medications increase resting motor threshold (RMT), the current aim was to examine the similarities and differences in post-drug TEPs, depending on whether stimulation intensity was adjusted to take account of post-drug RMT increase...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29096164/potential-factors-impacting-health-related-quality-of-life-among-patients-with-epilepsy-results-from-the-united-arab-emirates
#9
Taoufik Alsaadi, Seada Kassie, Khadija El Hammasi, Tarek M Shahrour, Mustafa Shakra, Lamya Turkawi, Wassim Nasreddine, Mufeed Raoof
PURPOSE: to investigate potential factors impacting HRQOL among PWE at a medical facility in the UAE. METHODS: Depression, anxiety, and health-related quality of life were assessed in 160 adult patients with epilepsy from September 2014 to January 2015 at Sheikh Khalifa Medical City (SKMC). The World Health Organization Quality of Life abbreviated scale (WHOQOL-BREF), the Patient Health Questionnaire nine-item (PHQ-9) depression scale, and Generalized Anxiety Disorder seven-item (GAD-7) scale were administered...
October 28, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29076421/seizures-and-anticonvulsants-in-brain-tumours-frequency-mechanisms-and-anti-epileptic-management
#10
Charles Vecht, Louis Royer-Perron, Caroline Houillier, Gilles Huberfeld
In cancer, epilepsy can be the manifestation of a primary brain tumour, metastatic disease, vascular or surgical complications, opportunistic infection or secondary to anti-tumour therapy. Seizures are frequently the first symptom of a brain tumour. The epilepsy is related to elevated extracellular glutamate stimulating NMDA- and AMPA-receptors and to the formation of D-2HG which resembles glutamate in IDH1 mutated gliomas. Epilepsy as presenting sign is associated with a longer survival in low- and high- grade gliomas, particularly with the IDH1 mutation...
October 27, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29063291/predictive-factors-of-drug-resistant-epilepsy-in-children-presenting-under-2-years-of-age-experience-of-a-tertiary-center-in-turkey
#11
Edibe Pembegul Yildiz, Dilek Gunes, Gonca Bektas, Tugce Aksu Uzunhan, Burak Tatli, Mine Caliskan, Nur Aydinli, Meral Ozmen
Population-based studies report that children with epilepsy have relatively better prognosis than those with an onset at infancy, though studies about this period are limited. We aimed to evaluate the etiology in infant epilepsy less than 2 years of age and foreseeable risk factors for anti-epileptic drug resistance. We evaluated the patients who were presented to the division of pediatric neurology in our university hospital with seizures when they were between 1 and 24 months of age and diagnosed as epilepsy...
October 23, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29059611/validating-epilepsy-diagnoses-in-routinely-collected-data
#12
Beata Fonferko-Shadrach, Arron S Lacey, Catharine P White, H W Rob Powell, Inder M S Sawhney, Ronan A Lyons, Phil E M Smith, Mike P Kerr, Mark I Rees, W Owen Pickrell
PURPOSE: Anonymised, routinely-collected healthcare data is increasingly being used for epilepsy research. We validated algorithms using general practitioner (GP) primary healthcare records to identify people with epilepsy from anonymised healthcare data within the Secure Anonymised Information Linkage (SAIL) databank in Wales, UK. METHOD: A reference population of 150 people with definite epilepsy and 150 people without epilepsy was ascertained from hospital records and linked to records contained within SAIL (containing GP records for 2...
October 13, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29057860/resting-state-fmri-findings-in-patients-with-first-episode-idiopathic-epilepsy-before-and-after-treatment
#13
Peng-Fei Qiao, Guang-Ming Niu
OBJECTIVE: To detect resting-state functional MRI (rsfMRI) changes and their relationships with the clinical curative effect of anti-epileptic drugs (AEDs) for complex partial seizures (CPS) in epilepsy patients using the fractional amplitude of low frequency fluctuation (fALFF). METHODS: rfMRI data from 14 CPS patients enrolled between June 2015 and June 2016 in Department of Neurology, Affiliated Hospital of Inner Mongolia Medical University were retrospectively investigated and compared with findings from 14 healthy age-, gender-, handedness-, and education-matched subjects...
October 2017: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/29053735/characterization-of-the-first-knock-out-aldh7a1-zebrafish-model-for-pyridoxine-dependent-epilepsy-using-crispr-cas9-technology
#14
Nikita Zabinyakov, Garrett Bullivant, Feng Cao, Matilde Fernandez Ojeda, Zheng Ping Jia, Xiao-Yan Wen, James J Dowling, Gajja S Salomons, Saadet Mercimek-Andrews
Pyridoxine dependent epilepsy (PDE) is caused by likely pathogenic variants in ALDH7A1 (PDE-ALDH7A1) and inherited autosomal recessively. Neurotoxic alpha-amino adipic semialdehyde (alpha-AASA), piperideine 6-carboxylate and pipecolic acid accumulate in body fluids. Neonatal or infantile onset seizures refractory to anti-epileptic medications are clinical features. Treatment with pyridoxine, arginine and lysine-restricted diet does not normalize neurodevelopmental outcome or accumulation of neurotoxic metabolites...
2017: PloS One
https://www.readbyqxmd.com/read/29034101/lamotrigine-induced-sexual-dysfunction-and-non-adherence-case-analysis-with-literature-review
#15
Kenneth R Kaufman, Melissa Coluccio, Kartik Sivaraaman, Miriam Campeas
BACKGROUND: Optimal anti-epileptic drug (AED) treatment maximises therapeutic response and minimises adverse effects (AEs). Key to therapeutic AED treatment is adherence. Non-adherence is often related to severity of AEs. Frequently, patients do not spontaneously report, and clinicians do not specifically query, critical AEs that lead to non-adherence, including sexual dysfunction. Sexual dysfunction prevalence in patients with epilepsy ranges from 40 to 70%, often related to AEDs, epilepsy or mood states...
September 2017: BJPsych Open
https://www.readbyqxmd.com/read/29031193/the-retention-of-lacosamide-in-patients-with-epilepsy-and-intellectual-disability-in-three-specialised-institutions
#16
J Brenner, H J M Majoie, S van Beek, J A Carpay
PURPOSE: We describe the effectiveness of lacosamide as adjunctive therapy in patients with epilepsy and an intellectual disability. This information is relevant, as few data exist pertaining to this population with a high prevalence of (intractable) epilepsy. METHODS: We performed a retrospective study in three specialised institutions. Inclusion criteria were (1) focal onset or symptomatic generalized (2) therapy-resistant epilepsy, (3) intellectual disability and (4) residence in a care-facility for people with intellectual disabilities (PWID)...
October 3, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29023170/ampa-receptors-and-perampanel-behind-selected-epilepsies-current-evidence-and-future-perspectives
#17
Carlo Di Bonaventura, Angelo Labate, Marta Maschio, Stefano Meletti, Emilio Russo
The alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are the major mediators of glutamate-mediated excitatory neurotransmission, and are critical for synchronization and spread of epileptic activity. Areas covered: AMPA receptor antagonists have been also developed as antiepileptic drugs and perampanel (PER) is the first highly selective, non-competitive AMPA-type glutamate receptor antagonist that is available on the market. It is approved as adjunctive therapy for the treatment of partial-onset seizures with or without secondary generalization, and for primary generalized tonic-clonic seizures in idiopathic generalized epilepsy, in patients aged ≥ 12 years...
October 17, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29021465/a-case-of-insulinoma-with-a-history-of-epilepsy-still-a-possible-misleading-factor-in-the-early-diagnosis-of-insulinoma
#18
Takaaki Murakami, Takafumi Yamashita, Daisuke Yabe, Toshihiko Masui, Yuki Teramoto, Sachiko Minamiguchi, Keisho Hirota, Masahito Ogura, Kazuaki Nagashima, Nobuya Inagaki
A delayed diagnosis of insulinoma remains a clinical issue. Hypoglycemic symptoms can mimic neuropsychiatric disorders such as epilepsy. A 27-year-old woman with a history of epilepsy and anti-epileptic drugs (AEDs) developed repeated seizures and neuropsychiatric symptoms after a 9-year asymptomatic interval. She had received transient treatment with AEDs before the possibility of hypoglycemia was considered. Following a clinical diagnosis of insulinoma, distal pancreatectomy was performed; her seizures didn't occur again...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28982319/sexual-dysfunction-in-epilepsy-and-the-role-of-anti-epileptic-drugs
#19
Mahinda Yogarajah, Marco Mula
BACKGROUND: Sexual dysfunction is very common in patients with epilepsy. OBJECTIVE: We sought to review the published literature around sexual dysfunction in epilepsy, and particularly the role played by anti-convulsant drugs. METHOD: We searched all related articles on PubMed using the search terms sexual dysfunction, various AEDs and epilepsy, and restricted the search to English language articles. RESULTS: The most common manifestations of sexual dysfunction in patients with epilepsy are hyposexuality and erectile dysfunction...
October 4, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28981225/-neuropathic-pain-treatment
#20
D Lossignol
INTRODUCTION: neuropathic pain is a frequent complication and results from numerous mechanisms, (infectious, post traumatic, metabolic, vascular) or toxic (i.e. medications). It is a complex entity due to its pathophysiology and its clinical features, but remains under diagnosed despite medical awareness. MATERIAL AND METHOD: we reviewed the recent literature on evaluation and treatment of neuropathic pain with a focus on published guidelines. RESULTS: scales and questionnaires are available (DN 4, LANSS, etc...
2017: Revue Médicale de Bruxelles
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