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https://www.readbyqxmd.com/read/28314968/-when-is-cytoreductive-nephrectomy-not-beneficial-for-patients-with-metastatic-renal-cell-carcinoma
#1
Martin Schostak
Primary tumor resection in patients with synchronous metastatic renal cell carcinoma and a good performance status corresponds to a guideline recommendation which, however, is based on weak data from the era of cytokine therapy. This article presents arguments that weigh heavily against cytoreductive nephrectomy. From a molecular genetic viewpoint, the intervention eliminates only the easiest adversary but cannot prevent cancer-related death. Therefore, benefits and risks must be carefully and critically considered...
March 17, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28299325/protective-effects-of-the-segmental-renal-artery-clamping-technique-on-ischemia-reperfusion-injury-in-db-db-diabetic-mice
#2
Chao Liang, Jundong Zhu, Chenkui Miao, Shangqian Wang, Lei Zhang, Pu Li, Zengjun Wang, Pengfei Shao
Renal ischemia-reperfusion (I/R) injury is inevitable in partial nephrectomy and other kidney surgeries, with a higher incidence in patients with renal insufficiency. This study aimed to investigate the protective effects of precise segmental renal artery clamping (SRAC) against renal I/R injury in db/db diabetic mice, compared with conventional renal artery clamping (RAC). Grape seed extract, a powerful free radical scavenger, was administered to diabetic mice for 4 weeks before operation in subgroups (30 mg/kg/d)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28288191/influence-of-tumor-size-on-oncological-outcomes-of-pathological-t3an0m0-renal-cell-carcinoma-treated-by-radical-nephrectomy
#3
Luyao Chen, Xin Ma, Hongzhao Li, Liangyou Gu, Xintao Li, Yu Gao, Yongpeng Xie, Xu Zhang
OBJECTIVE: To evaluate the prognostic significance of tumor size in pathological T3aN0M0 renal cell carcinoma (RCC) treated by radical nephrectomy. MATERIALS AND METHODS: Patients who underwent radical nephrectomy for sporadic RCC with pathological T3aN0M0 RCC at our institution between January 2006 and June 2015 were identified. The entire cohort was divided into two groups according to the cutoff of tumor size obtained from receiver operating characteristic (ROC) curve...
2017: PloS One
https://www.readbyqxmd.com/read/28283911/recovery-of-renal-function-after-administration-of-adipose-tissue-derived-stromal-vascular-fraction-in-rat-model-of-acute-kidney-injury-induced-by-ischemia-reperfusion-injury
#4
Chunwoo Lee, Myoung Jin Jang, Bo Hyun Kim, Jin Young Park, Dalsan You, In Gab Jeong, Jun Hyuk Hong, Choung-Soo Kim
Acute kidney injury (AKI) induced by ischemia/reperfusion (I/R) injury is a major challenge in critical care medicine. The purpose of this study is to determine the therapeutic effects of the adipose-tissue-derived stromal vascular fraction (SVF) and the optimal route for SVF delivery in a rat model of AKI induced by I/R injury. Fifty male Sprague-Dawley rats were randomly divided into five groups (10 animals per group): sham, nephrectomy control, I/R injury control, renal arterial SVF infusion and subcapsular SVF injection...
March 10, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28281740/comparison-of-laparoendoscopic-single-site-less-and-multiport-laparoscopic-radical-nephrectomy-for-clinical-t1b-and-t2a-renal-masses
#5
Abd-El R Hassan, Omer A Raheem, Sean Berquist, Alp T Beksac, Aaron Bloch, Charles Field, Hak J Lee, Reza Mehrazin, Marc Holden, Michelle McDONALD, Zachary Hamilton, Michael Liss, Ithaar H Derweesh
BACKGROUND: To compare outcomes of Laparoendoscopic single-site surgery (LESS) and multiport laparoscopic (MPL) Radical Nephrectomy (RN) for clinical T1b/T2a renal masses, as concerns continue regarding suitability and benefit of LESS for larger renal masses. METHODS: Retrospective single-surgeon comparison of LESS- and MPL-RN between 7/2005 and 11/2014. 63 patients underwent LESS-RN (44 cT1b/19 cT2a); 133 underwent MPL (83 cT1b/50 cT2a). All patients were managed with a standardized care pathway...
March 10, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28281114/value-of-3d-printing-for-the-comprehension-of-surgical-anatomy
#6
Stefania Marconi, Luigi Pugliese, Marta Botti, Andrea Peri, Emma Cavazzi, Saverio Latteri, Ferdinando Auricchio, Andrea Pietrabissa
BACKGROUND: In a preliminary experience, we claimed the potential value of 3D printing technology for pre-operative counseling and surgical planning. However, no objective analysis has ever assessed its additional benefit in transferring anatomical information from radiology to final users. We decided to validate the pre-operative use of 3D-printed anatomical models in patients with solid organs' diseases as a new tool to deliver morphological information. METHODS: Fifteen patients scheduled for laparoscopic splenectomy, nephrectomy, or pancreatectomy were selected and, for each, a full-size 3D virtual anatomical object was reconstructed from a contrast-enhanced MDCT (Multiple Detector Computed Tomography) and then prototyped using a 3D printer...
March 9, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28270958/laparoscopic-donor-nephrectomy-complications-and-management-a-single-center-experience
#7
Volkan Tuğcu, Selçuk Şahin, İsmail Yiğitbaşı, Nevzat Can Şener, Fatih Gökhan Akbay, Ali İhsan Taşçı
OBJECTIVE: To present our experience with laparoscopic donor nephrectomy (LDN), our complications and management modalities. Material and methods: Fifty-one transperitoneal LDNs performed in our clinic between the years 2011, and 2015, were evaluated retrospectively. Demographic characteristics of the patients, operative and postoperative data and complications were evaluated. RESULTS: Nineteen female and 32 male patients with ages ranging from 24 to 65 years underwent left- (n=44), and right-sided (n=7) LDNs...
March 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28270950/trends-of-partial-and-radical-nephrectomy-in-managing-small-renal-masses
#8
Ibrahim Khalid Al Saidi, Kholoud Saleh Alqasem, Saeda Turki Gharaibeh, Naim Z N Qamhia, Ibrahim Abukhiran, Ali Ahmad Al-Daghmin
OBJECTIVE: Use of partial nephrectomy (PN) for renal tumors appears to have relatively lower incidence rates in Jordan. We sought to characterize its trend at King Hussein Cancer Center for the last 10 years. MATERIAL AND METHODS: A retrospective review of our renal cell cancer data was performed. We identified 169 patients who had undergone surgery for renal tumors measuring ≤7 cm between 2005 and 2015. We characterized tumor size, pathology, type of surgery and clinical outcomes...
March 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28261895/bilateral-native-nephrectomy-reduces-systemic-oxalate-level-after-combined-liver-kidney-transplant-a-case-report
#9
Vincenzo Villani, Neena Gupta, Nahel Elias, Parsia A Vagefi, James F Markmann, Elahna Paul, Avram Z Traum, Heidi Yeh
Primary hyperoxaluria type 1 (PH1) is a rare liver enzymatic defect that causes overproduction of plasma oxalate. Accumulation of oxalate in the kidney and subsequent renal failure are fatal to PH1 patients often in pediatric age. Combined liver and kidney transplantation is the therapy of choice for end-stage renal disease due to PH1. Levels of plasma oxalate remain elevated for several months after liver transplantation, as the residual body oxalate is slowly excreted. Patients with persistent hyperoxaluria after transplant often require hemodialysis, and accumulation of residual oxalate in the kidney can induce graft dysfunction...
March 5, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28255220/treatment-of-complex-combined-renal-artery-aneurysm-and-renal-arteriovenous-fistula-with-nephrectomy
#10
R W Franz, C F Tanga
Renal artery aneurysms (RAAs) and renal arteriovenous fistulas (RAVFs) are rare lesions occurring in less than 1% of the population. Understanding treatment options is important in the care of these patients. Depending on the type of disease process, endovascular techniques, vascular bypass, renal autotransplantation, or nephrectomy may be indicated. The case reported describes a combined RRA and RAVF treated with nephrectomy.
March 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/28248049/-retroperitoneoscopic-radical-nephrectomy-with-inferior-vena-cava-thrombectomy
#11
D V Perlin, V P Zipunnikov, I N Dymkov, A O Shmanev
INTRODUCTION: Although laparoscopic radical nephrectomy has confidently established itself as the "gold standard" for treating renal cell carcinoma, reports on laparoscopic level II-III inferior vena cava (IVC) tumor thrombus thrombectomy are still lacking. MATERIALS AND METHODS: From September 2013 through April 2015, three patients with renal cell carcinoma and level II IVC tumor thrombi underwent laparoscopic radical nephrectomy with IVC thrombectomy using a retroperitoneal approach...
December 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28248043/-clinical-and-morphological-parallels-in-the-validation-of-surgical-treatment-of-nephrotuberculosi
#12
B I Novikov, S N Skornyakov, R B Berdnikov, A V Savelev
AIM: To Study clinical and morphological variants of kidney tuberculosis (KTB), for grounding a tactics of surgical treatment. MATERIALS AND METHODS: There were 107 examined patients (patients with cavitary lesions of kidneys: cavernous and multi-cavernous), operated in different phases of KTB. There were 56 men (52,3%) and women - 51(47,7%). The mean age of patients was 57,6 years (23-84 years). All the patients had a complex examination, including X-ray and ultrasound investigations, computer tomography ( was performed selectively), bacteriological examinations of urine and morphological examinations of removed kidneys or their parts...
December 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28242987/renal-metastasis-and-dual-18-f-fluorodeoxyglucose-and-131-i-avid-skeletal-metastasis-in-a-patient-with-papillary-thyroid-cancer
#13
Prashanth Kulkarni, Pobbi Setty Radhakrishna Gupta Rekha, Meghana Prabhu, Sunil Hejjaji Venkataramarao, Nalini Raju, Naveen Hedne Chandrasekhar, Subramanian Kannan
Differentiated thyroid carcinoma (DTC) though usually behaves in an indolent manner, can have unusual metastatic presentation. Initial presentation of metastatic disease has been reported in 1-12% of DTC being less frequent in papillary (~2%) than in follicular (~10%) thyroid carcinoma. Renal metastasis from DTC is very rare. To our knowledge, only about 30 cases have been reported in the English literature to date. To make clinicians aware that management of such high-risk thyroid cancer frequently requires novel multimodality imaging and therapeutic techniques...
January 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28242025/treatment-of-caval-vein-thrombosis-associated-with-renal-tumors
#14
Carlos Jiménez-Romero, María Conde, Federico de la Rosa, Alejandro Manrique, Jorge Calvo, Óscar Caso, Carlos Muñoz, Alberto Marcacuzco, Iago Justo
INTRODUCTION: Renal carcinoma represents 3% of all solid tumors and is associated with renal or inferior caval vein (IVC) thrombosis between 2-10% of patients, extending to right atrial in 1% of cases. METHODS: This is a retrospective study that comprises 5 patients who underwent nephrectomy and thrombectomy by laparotomy because of renal tumor with IVC thrombosis level iii. RESULTS: Four patients were males and one was female, and the mean age was 57,2 years (range: 32-72)...
February 24, 2017: Cirugía Española
https://www.readbyqxmd.com/read/28237283/ablative-therapies-for-renal-tumors-patient-selection-treatment-planning-and-follow-up
#15
Jean-Michel Correas, Christophe Delavaud, Jules Gregory, Thomas Le Guilchet, Lionel Lamhaut, Marc-Olivier Timsit, Arnaud Méjean, Olivier Hélénon
The increased use of abdominal imaging has led to a major increase in small renal tumors incidence particularly in the elderly population. Their management is evolving with the development of percutaneous ablation, particularly radiofrequency ablation, cryoablation, and microwave ablation. The typical indications that must be validated by a multidisciplinary committee include solid tumors less than 3cm in patients with multiple comorbidity factors (including age), contraindications to surgery, hereditary renal cancer, bilateral renal tumors, solitary kidney, pre-existing chronic kidney disease, or at high risk of predialysis renal function after partial nephrectomy...
February 2017: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/28216391/should-hand-assisted-retroperitoneoscopic-nephrectomy-replace-the-standard-laparoscopic-technique-for-living-donor-nephrectomy-a-meta-analysis
#16
REVIEW
Ahmed Elmaraezy, Abdelrahman Ibrahim Abushouk, Moaz Kamel, Ahmed Negida, Omar Naser
OBJECTIVE: We performed this meta-analysis to compare hand-assisted retroperitoneoscopic (HARP) and traditional laparoscopic (TLS) techniques for living donor nephrectomy. METHODS: We searched PubMed, Cochrane Central, EMBASE, and Web of science for prospective studies, comparing HARP and TLS techniques. Data were extracted from eligible studies and pooled as risk ratios (RR) or standardized mean difference (SMD), using RevMan software (version 5.3 for windows)...
February 17, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28193294/myxoma-of-the-kidney-an-unusual-benign-renal-tumor-a-case-report
#17
Somuah Tenkorang, Youssef Kharbach, Jean-Paul Omana, Boubacar Efared, Soufiane Mellas, Mohammed Fadl Tazi, Mohamed Sekal, Taoufik Harmouch, Abdelhak Khallouk, Jamal Mohammed El Fassi, Jalal Eddine El Ammari, Moulay Hassan Farih
BACKGROUND: Myxomas are rare benign soft tissue tumors. The kidney is an unusual location for this tumor. For this reason, less than 15 cases of renal myxoma have been reported in the English literature. There are no specific clinical and radiological features reported for this tumor that allow a preoperative diagnosis enabling a conservative treatment. CASE PRESENTATION: We report another case of renal myxoma found in a 50-year-old Moroccan woman who presented with a right dull flank pain...
February 14, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28159494/compensatory-structural-and-functional-adaptation-after-radical-nephrectomy-for-renal-cell-carcinoma-according-to-preoperative-stage-of-chronic-kidney-disease-choi-dk-jung-sb-park-bh-jeong-bc-seo-si-jeon-ss-lee-hm-choi-hy-jeon-hg-j-urol-2015-oct-194-4-910-5
#18
Raman Jay, S B Jung, B H Park, B C Jeong, S I Seo, S S Jeon, H M Lee, H Y Choi, H G Jeon
PURPOSE: We investigated structural hypertrophy and functional hyperfiltration as compensatory adaptations after radical nephrectomy in patients with renal cell carcinoma according to the preoperative chronic kidney disease stage. MATERIALS AND METHODS: We retrospectively identified 543 patients who underwent radical nephrectomy for renal cell carcinoma between 1997 and 2012. Patients were classified according to preoperative glomerular filtration rate as no chronic kidney disease-glomerular filtration rate 90ml/min/1...
March 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28130928/renal-graft-intolerance-syndrome-in-late-graft-failure-patients-efficacy-and-safety-of-embolization-as-first-line-treatment-compared-to-surgical-removal
#19
Ghalib Al Badaai, Vincent Pernin, Valérie Garrigue, Valérie Monnin, Thibaut Murez, Saad Ed Dine Fadli, Nicolas Molinari, Rodolphe Thuret, François Iborra, Georges Mourad
BACKGROUND: Although renal graft percutaneous embolization was introduced to avoid the risk associated with graft nephrectomy, there is no universal consensus about its indications and results. OBJECTIVE: Evaluate the efficacy of graft embolization in the treatment of graft intolerance syndrome as well as its safety compared to surgical removal with respect to complications and other morbidity measures. MATERIALS AND METHODS: A retrospective observational study comparing 2 groups of patients treated for graft intolerance syndrome: Group 1: patients who had embolization as first line treatment and Group 2: patients directly treated by surgical removal...
January 28, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28129737/repeated-remote-ischemic-preconditioning-and-isoflurane-anesthesia-in-an-experimental-model-of-renal-ischemia-reperfusion-injury
#20
Theo P Menting, Mehmet Ergun, Moira H D Bruintjes, Kimberley E Wever, Roger M L M Lomme, Harry van Goor, Michiel C Warlé
BACKGROUND: In animal studies, remote ischemic preconditioning (RIPC) and anesthetic preconditioning are successful in reducing renal ischemia reperfusion injury (IRI), however the protective effect of RIPC may be improved by repeating the RIPC stimulus. METHODS: Sprague-Dawley rats underwent unilateral nephrectomy followed by 30 min of renal pedicle clamping. Animals were allocated into six groups: sham, control (IRI), RepISO (daily isoflurane anesthesia), RIPC (single dose isoflurane anesthesia and single dose RIPC), RepISO + RIPC (7-day isoflurane anesthesia and single dose RIPC) and RepISO + RepRIPC (7-day isoflurane anesthesia with 7-day RIPC)...
January 28, 2017: BMC Anesthesiology
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