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https://www.readbyqxmd.com/read/29913626/vasoactive-intestinal-peptide-vip-and-pituitary-adenylate-cyclase-activating-polypeptide-pacap-in-the-circulation-after-sumatriptan
#1
Jakob Møller Hansen, Jan Fahrenkrug, Jesper Petersen, Troels Wienecke, Karsten Skovgaard Olsen, Messoud Ashina
Background and purpose The origin of migraine pain is still elusive, but increasingly researchers focus on the neuropeptides in the perivascular space of cranial vessels as important mediators of nociceptive input during migraine attacks. The parasympathetic neurotransmitters, pituitary adenylate cyclase activating peptide-38 (PACAP38) and vasoactive intestinal peptide (VIP) may be released from parasympathetic fibres and activate sensory nerve fibres during migraine attacks. Triptans are effective and well tolerated in acute migraine management but the exact mechanism of action is still debated...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29864987/effect-of-cocoa-on-endorphin-levels-and-craniofacial-muscle-sensitivity-in-healthy-individuals
#2
A H Simoni, A Randers, K Jønsson, S Arpe, J N Poulsen, P Gazerani
Aims Migraine headache is a recurrent incapacitating neurovascular disorder. A combination of events occurring within the trigeminovascular system has been suggested to underlie migraine pathogenesis, including release of inflammatory neuropeptides with subsequent effects on meningeal vessels and sensory transmission. Increased craniofacial muscle tenderness is also present in patients with migraine and a lower β-endorphin concentration has been observed in these patients. Several external factors have been identified, which can modulate migraine...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29860871/erratum
#3
(no author information available yet)
Zhao Y, Martins-Oliveira M, Akerman S, and Goadsby PJ. Comparative effects of traditional Chinese and Western migraine medicines in an animal model of nociceptive trigeminovascular activation. Cephalalgia. Epub ahead of print 24 August 2017. DOI: 10.1177/0333102417728245 In this article, some data was incorrectly reported in the following sentences. The corrections are shown in bold font below: Page 2: Fifty-four male Sprague-Dawley rats (250-370 g) were anesthetized using a single dose of sodium pentobarbital (60 mg kg-1 i...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29848264/the-therapeutic-impact-of-new-migraine-discoveries
#4
Melinda Lukács, Janos Tajti, Ferenc Fülöp, Jozsef Toldi, Lars Edvinsson, Laszlo Vécsei
BACKGROUND: Migraine is one the most disabling neurological conditions and associates with high socio-economic costs. Though certain aspects of the pathomechanism of migraine are still incompletely understood, the leading hypothesis implicates the role of the activation of the trigeminovascular system. Triptans are considered the current gold standard therapy for migraine attacks; however, their use in clinical practice is limited. Prophylactic treatment includes non-specific approaches for migraine prevention...
May 29, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29802484/characterization-of-the-trigeminovascular-actions-of-several-adenosine-a-2a-receptor-antagonists-in-an-in-vivo-rat-model-of-migraine
#5
Kristian A Haanes, Alejandro Labastida-Ramírez, Kayi Y Chan, René de Vries, Brian Shook, Paul Jackson, Jimmy Zhang, Christopher M Flores, Alexander H J Danser, Carlos M Villalón, Antoinette MaassenVanDenBrink
BACKGROUND: Migraine is considered a neurovascular disorder, but its pathophysiological mechanisms are not yet fully understood. Adenosine has been shown to increase in plasma during migraine attacks and to induce vasodilation in several blood vessels; however, it remains unknown whether adenosine can interact with the trigeminovascular system. Moreover, caffeine, a non-selective adenosine receptor antagonist, is included in many over the counter anti-headache/migraine treatments. METHODS: This study used the rat closed cranial window method to investigate in vivo the effects of the adenosine A2A receptor antagonists with varying selectivity over A1 receptors; JNJ-39928122, JNJ-40529749, JNJ-41942914, JNJ-40064440 or JNJ-41501798 (0...
May 25, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29794878/trigeminal-ganglion-transcriptome-analysis-in-two-rat-models-of-medication-overuse-headache-reveals-coherent-and-widespread-induction-of-pronociceptive-gene-expression-patterns
#6
Daniela Buonvicino, Matteo Urru, Mirko Muzzi, Giuseppe Ranieri, Cristina Luceri, Claudia Oteri, Andrea Lapucci, Alberto Chiarugi
We attempted to gather information on the pathogenesis of medication-overuse headache (MOH), as well as on the neurochemical mechanisms through which symptomatic medication overuse concurs to headache chronification. Transcriptional profiles were therefore evaluated as an index of the homeostasis of the trigeminovascular system in the trigeminal ganglion of female rats exposed for 1 month to daily oral doses of eletriptan or indomethacin. We report that both drug treatments change trigeminal ganglion gene expression to a similar extend...
May 23, 2018: Pain
https://www.readbyqxmd.com/read/29720814/paroxysmal-hemicrania
#7
REVIEW
Chinar Osman, Anish Bahra
Paroxysmal hemicrania (PH) is a primary headache disorder belonging to the group of trigeminal autonomic cephalalgias(TACs). Patients typically experience intense lateralzsed headaches with pain primarily in the ophthalmic trigeminal distribution (V1) associated with superimposed ipsilateral cranial autonomic features. PH is distinguished from other TACs by an exquisite responsiveness to therapeutic doses of indomethacin. Patients may need to be maintained on indomethacin for several months before trials of reduction can be attempted...
April 2018: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/29720812/cluster-headache-epidemiology-pathophysiology-clinical-features-and-diagnosis
#8
REVIEW
Diana Yi-Ting Wei, Jonathan Jia Yuan Ong, Peter James Goadsby
Cluster headache is a primary headache disorder affecting up to 0.1% of the population. Patients suffer from cluster headache attacks lasting from 15 to 180 min up to 8 times a day. The attacks are characterized by the severe unilateral pain mainly in the first division of the trigeminal nerve, with associated prominent unilateral cranial autonomic symptoms and a sense of agitation and restlessness during the attacks. The male-to-female ratio is approximately 2.5:1. Experimental, clinical, and neuroimaging studies have advanced our understanding of the pathogenesis of cluster headache...
April 2018: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/29697154/a-phase-by-phase-review-of-migraine-pathophysiology
#9
David W Dodick
Migraine is a common, disabling neurological disorder characterized by multiple phases: premonitory, aura, headache, postdrome, and interictal. Our understanding of the pathophysiology of each phase of migraine has evolved over recent years. The premonitory phase begins as early as 3 days before the headache phase, and involves a complex interplay between various cortical and subcortical brain regions, including the hypothalamus and brainstem nuclei that modulate nociceptive signaling. The headache phase involves activation of the trigeminovascular system, a pathway that is well characterized...
May 2018: Headache
https://www.readbyqxmd.com/read/29691490/cgrp-as-the-target-of-new-migraine-therapies-successful-translation-from-bench-to-clinic
#10
REVIEW
Lars Edvinsson, Kristian Agmund Haanes, Karin Warfvinge, Diana N Krause
Treatment of migraine is on the cusp of a new era with the development of drugs that target the trigeminal sensory neuropeptide calcitonin gene-related peptide (CGRP) or its receptor. Several of these drugs are expected to receive approval for use in migraine headache in 2018 and 2019. CGRP-related therapies offer considerable improvements over existing drugs as they are the first to be designed specifically to act on the trigeminal pain system, they are more specific and they seem to have few or no adverse effects...
June 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29661478/chronic-adriamycin-treatment-impairs-cgrp-mediated-functions-of-meningeal-sensory-nerves
#11
Éva Deák, Judit Rosta, Krisztina Boros, Gyöngyi Kis, Péter Sántha, Karl Messlinger, Gábor Jancsó, Mária Dux
Adriamycin is a potent anthracycline-type antitumor agent, but it also exerts potentially serious side effects due to its cardiotoxic and neurotoxic propensity. Multiple impairments in sensory nerve functions have been recently reported in various rat models. The present experiments were initiated in an attempt to reveal adriamycin-induced changes in sensory effector functions of chemosensitive meningeal afferents. Meningeal blood flow was measured with laser Doppler flowmetry in the parietal dura mater of adult male Wistar rats...
June 2018: Neuropeptides
https://www.readbyqxmd.com/read/29615860/endocannabinoid-system-and-migraine-pain-an-update
#12
REVIEW
Rosaria Greco, Chiara Demartini, Anna M Zanaboni, Daniele Piomelli, Cristina Tassorelli
The trigeminovascular system (TS) activation and the vasoactive release from trigeminal endings, in proximity of the meningeal vessels, are considered two of the main effector mechanisms of migraine attacks. Several other structures and mediators are involved, however, both upstream and alongside the TS. Among these, the endocannabinoid system (ES) has recently attracted considerable attention. Experimental and clinical data suggest indeed a link between dysregulation of this signaling complex and migraine headache...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29541053/non-rapid-eye-movement-sleep-parasomnias-and-migraine-a-role-of-orexinergic-projections
#13
Antonietta Messina, Ilaria Bitetti, Francesco Precenzano, Diego Iacono, Giovanni Messina, Michele Roccella, Lucia Parisi, Margherita Salerno, Anna Valenzano, Agata Maltese, Monica Salerno, Francesco Sessa, Giuseppe Davide Albano, Rosa Marotta, Ines Villano, Gabriella Marsala, Christian Zammit, Francesco Lavano, Marcellino Monda, Giuseppe Cibelli, Serena Marianna Lavano, Beatrice Gallai, Roberto Toraldo, Vincenzo Monda, Marco Carotenuto
Introduction: Sleep and migraine share a common pathophysiological substrate, although the underlying mechanisms are unknown. The serotonergic and orexinergic systems are both involved in the regulation of sleep/wake cycle, and numerous studies show that both are involved in the migraine etiopathogenesis. These two systems are anatomically and functionally interconnected. Our hypothesis is that in migraine a dysfunction of orexinergic projections on the median raphe (MR) nuclei, interfering with serotonergic regulation, may cause Non-Rapid Eye Movement parasomnias, such as somnambulism...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29532195/the-big-cgrp-flood-sources-sinks-and-signalling-sites-in-the-trigeminovascular-system
#14
REVIEW
Karl Messlinger
BACKGROUND: Calcitonin gene-related peptide (CGRP) has long been a focus of migraine research, since it turned out that inhibition of CGRP or CGRP receptors by antagonists or monoclonal IgG antibodies was therapeutic in frequent and chronic migraine. This contribution deals with the questions, from which sites CGRP is released, where it is drained and where it acts to cause its headache proliferating effects in the trigeminovascular system. RESULTS: The available literature suggests that the bulk of CGRP is released from trigeminal afferents both in meningeal tissues and at the first synapse in the spinal trigeminal nucleus...
March 12, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29523978/pacap-and-its-role-in-primary-headaches
#15
REVIEW
Lars Edvinsson, János Tajti, Levente Szalárdy, László Vécsei
Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide implicated in a wide range of functions, such as nociception and in primary headaches. Regarding its localization, PACAP has been observed in the sensory trigeminal ganglion (TG), in the parasympathetic sphenopalatine (SPG) and otic ganglia (OTG), and in the brainstem trigeminocervical complex. Immunohistochemistry has shown PACAP-38 in numerous cell bodies of SPG/OTG, co-stored with vasoactive intestinal peptide (VIP), nitric oxide synthase (NOS) and, to a minor degree, with choline acetyltransferase...
March 9, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29493566/cluster-headache
#16
REVIEW
Arne May, Todd J Schwedt, Delphine Magis, Patricia Pozo-Rosich, Stefan Evers, Shuu-Jiun Wang
Cluster headache is an excruciating, strictly one-sided pain syndrome with attacks that last between 15 minutes and 180 minutes and that are accompanied by marked ipsilateral cranial autonomic symptoms, such as lacrimation and conjunctival injection. The pain is so severe that female patients describe each attack as worse than childbirth. The past decade has seen remarkable progress in the understanding of the pathophysiological background of cluster headache and has implicated the brain, particularly the hypothalamus, as the generator of both the pain and the autonomic symptoms...
March 1, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29438129/central-and-peripheral-processes-in-headache
#17
Adithya Varma, Saurabh Jain, Arshad Majid, Milena De Felice
PURPOSE OF REVIEW: Migraine is an extremely incapacitating collection of neurological symptoms that usually includes a severe, throbbing, recurring pain on one side of the head. The World Health Organization ranks migraine as the third most prevalent disease and the seventh commonest primary pain condition in the world. Trigeminovascular-mediated central sensitization has been implicated in the development of migraine symptoms including pain following light touch. This review explores the activation and sensitization of the brain systems that have emerged from recent studies and that contribute to migraine...
June 2018: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/29357683/cerebellar-involvement-in-migraine
#18
Lieke Kros, Chantal A Angueyra Aristizábal, Kamran Khodakhah
Background Although there is a great wealth of knowledge about the neurobiological processes underlying migraine and its accompanying symptoms, the mechanisms by which an attack starts remain elusive, and the disease remains undertreated. Although the vast majority of literature focuses on the involvement of the trigeminovascular systems and higher systems it innervates, such as thalamic and hypothalamic nuclei, several lines of evidence implicate the cerebellum in the pathophysiology of migraine. Aim In this review, we aim to summarize potential cerebellar involvement seen from different perspectives including the results from imaging studies, cerebellar connectivity to migraine-related brain structures, comorbidity with disorders implying cerebellar dysfunction, similarities in triggers precipitating both such disorders, and migraine and cerebellar expression of migraine-related genes and neuropeptides...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29352859/is-selective-5-ht-1f-receptor-agonism-an-entity-apart-from-that-of-the-triptans-in-antimigraine-therapy
#19
REVIEW
Eloísa Rubio-Beltrán, Alejandro Labastida-Ramírez, Carlos M Villalón, Antoinette MaassenVanDenBrink
Migraine is a neurovascular disorder that involves activation of the trigeminovascular system and cranial vasodilation mediated by release of calcitonin gene-related peptide (CGRP). The gold standard for acute migraine treatment are the triptans, 5-HT1B/1D/(1F) receptor agonists. Their actions are thought to be mediated through activation of: (i) 5-HT1B receptors in cranial blood vessels with subsequent cranial vasoconstriction; (ii) prejunctional 5-HT1D receptors on trigeminal fibers that inhibit trigeminal CGRP release; and (iii) 5-HT1B/1D/1F receptors in central nervous system involved in (anti)nociceptive modulation...
June 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29317063/trigeminal-long-term-potentiation-as-a-cellular-substrate-for-migraine
#20
Dong-Ho Youn
Most previous studies suggest that the subnucleus caudalis (Vc) of spinal trigeminal nucleus (Vsp) plays a key role in the generation and maintenance of migraine, a type of primary headache, by participating in the trigeminovascular system. Furthermore, the excitability of the Vc with the stimulation of the peripheral nociceptive fibers innervating the intracranial vessels or dura matter is regarded as a main cellular substrate for migraine. Here, a revised hypothesis is introduced, reinforcing the previous hypothesis and complementing it...
January 2018: Medical Hypotheses
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