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https://www.readbyqxmd.com/read/28430871/cluspro-peptidock-efficient-global-docking-of-peptide-recognition-motifs-using-fft
#1
Kathryn A Porter, Bing Xia, Dmitri Beglov, Tanggis Bohnuud, Nawsad Alam, Ora Schueler-Furman, Dima Kozakov
Summary: We present an approach for the efficient docking of peptide motifs to their free receptor structures. Using a motif based search, we can retrieve structural fragments from the Protein Data Bank (PDB) that are very similar to the peptide's final, bound conformation. We use a Fast Fourier Transform (FFT) based docking method to quickly perform global rigid body docking of these fragments to the receptor. According to CAPRI peptide docking criteria, an acceptable conformation can often be found among the top-ranking predictions...
April 18, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28417158/incidence-and-predictive-factors-of-internet-addiction-among-chinese-secondary-school-students-in-hong-kong-a-longitudinal-study
#2
Joseph T F Lau, Danielle L Gross, Anise M S Wu, Kit-Man Cheng, Mason M C Lau
PURPOSE: Internet use has global influences on all aspects of life and has become a growing concern. Cross-sectional studies on Internet addiction (IA) have been reported but causality is often unclear. More longitudinal studies are warranted. METHODS: We investigated incidence and predictors of IA conversion among secondary school students. A 12-month longitudinal study was conducted among Hong Kong Chinese Secondary 1-4 students (N = 8286). Using the 26-item Chen Internet Addiction Scale (CIAS; cut-off >63), non-IA cases were identified at baseline...
April 17, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28413437/gostag-gene-ontology-subtrees-to-tag-and-annotate-genes-within-a-set
#3
Brian D Bennett, Pierre R Bushel
BACKGROUND: Over-representation analysis (ORA) detects enrichment of genes within biological categories. Gene Ontology (GO) domains are commonly used for gene/gene-product annotation. When ORA is employed, often times there are hundreds of statistically significant GO terms per gene set. Comparing enriched categories between a large number of analyses and identifying the term within the GO hierarchy with the most connections is challenging. Furthermore, ascertaining biological themes representative of the samples can be highly subjective from the interpretation of the enriched categories...
2017: Source Code for Biology and Medicine
https://www.readbyqxmd.com/read/28412313/is-trial-of-labor-harmful-in-breech-delivery-a-cohort-comparison-for-breech-and-vertex-presentations
#4
Sonia Adjaoud, Romain Demailly, Sophie Michel-Semail, Thameur Rakza, Laurent Storme, Philippe Deruelle, C Garabedian, Damien Subtil
INTRODUCTION: Planned vaginal delivery in breech presentation is accompanied by an excess neonatal risk that has, however, rarely been compared to that of delivery in vertex presentation. Because of the severity of complications that can occur in long term follow up, the risk of asphyxia is of particular concern. MATERIAL AND METHODS: To assess immediate neonatal status after a planned vaginal delivery of fetuses in breech compared with vertex presentation, we planned a retrospective hospital cohort study of singleton term deliveries from 2000 to 2011...
April 12, 2017: J Gynecol Obstet Hum Reprod
https://www.readbyqxmd.com/read/28401406/the-impact-of-militarism-patriarchy-and-culture-on-israeli-women-s-reproductive-health-and-well-being
#5
Leeat Granek, Ora Nakash
PURPOSE: In this paper, we situate and frame Israeli women's reproductive health within the social, historical, political, cultural, and geographical context of Israeli women's lives. METHODS: We used a theoretical review in this paper. RESULTS: Militarism, patriarchy, and cultural values heavily shape and influence Jewish and Arab women's access to and experience of reproductive health when it comes to the imperative to have children, pregnancy, birth, access to contraception and abortion, and other reproductive healthcare services...
April 11, 2017: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/28390910/genome-wide-snps-resolve-phylogenetic-relationships-in-the-north-american-spruce-budworm-choristoneura-fumiferana-species-complex
#6
J R Dupuis, B M T Brunet, H M Bird, L M Lumley, G Fagua, B Boyle, R Levesque, M Cusson, J A Powell, F A H Sperling
High throughput sequencing technologies have revolutionized the potential to reconcile incongruence between gene and species trees, and numerous approaches have been developed to take advantage of these advances. Genotyping-by-sequencing is becoming a regular tool for gathering phylogenetic data, yet comprehensive evaluations of phylogenetic methods using these data are sparse. Here we use multiple phylogenetic and population genetic methods for genotyping-by-sequencing data to assess species relationships in a group of forest insect pests, the spruce budworm (Choristoneura fumiferana) species complex...
April 5, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28387800/molecular-characterization-of-chlamydia-pneumoniae-associated-to-atherosclerosis
#7
Loubna El Yazouli, Alexis Criscuolo, Hicham Hejaji, Mohamed Bouaaza, Naima Elmdaghri, Aziz Aroussi Alami, Abderahim Amraoui, Nadia Dakka, Fouzia Radouani
Chlamydia pneumoniae is a respiratory pathogen associated with chronic inflammatory diseases such as asthma and atherosclerosis, and its detection in human carotid and coronary atheroma suggests some support for its involvement in atherogenesis. The main objective of our study was to evaluate the association between Chlamydia pneumoniae and atherosclerosis in Moroccan patients through a case/control approach and detected strain genotyping. A total of 137 cases and 124 controls were enrolled, nested PCR was performed for Chlamydia pneumoniae screening of the peripheral blood mononuclear cells (PBMCs) of both cases and controls as well as atheroma plaques from 37 cases, and positive samples were subjected to sequencing for genotyping and phylogenetic analysis...
April 6, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28374466/post-operative-pain-relief-using-local-infiltration-analgesia-during-open-abdominal-hysterectomy-a-randomized-double-blind-study
#8
J M Hayden, J Oras, O I Karlsson, K G Olausson, S-E Thörn, A Gupta
BACKGROUND: Post-operative pain is common and often severe after open abdominal hysterectomy, and analgesic consumption high. This study assessed the efficacy of local infiltration analgesia (LIA) injected systematically into different tissues during surgery compared with saline on post-operative pain and analgesia. METHODS: Fifty-nine patients were randomized to Group LIA (n = 29) consisting of 156 ml of a mixture of 0.2% ropivacaine + 30 mg ketorolac + 0.5 mg (5 ml) adrenaline, where the drugs were injected systematically in the operating site, around the proximal vagina, the ligaments, in the fascia and subcutaneously, or to saline and intravenous ketorolac, Group C (Control, n = 28), in a double-blind study...
May 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28373257/prevalence-and-influencing-factors-of-hepatitis-b-among-a-rural-residential-population-in-zhejiang-province-china-a-cross-sectional-study
#9
Shigui Yang, Cheng Ding, Yuanxia Cui, Jie Wu, Chengbo Yu, Ping Chen, Kaijin Xu, Min Deng, Yiping Li, Juanjuan Liu, Pei Yin, Wen Ren, Yan Qiu, Qing Cao, Yuqing Zhou, Jun Yao, Bing Ruan, Jingjing Ren, Lanjuan Li
OBJECTIVES: To reveal the prevalence and associated influencing factors of hepatitis B among a rural residential population in Zhejiang, China, in order to help develop specific control strategies. METHODS: We conducted a cross-sectional study among a rural residential population in Zhejiang, China. Stratified multistage cluster sampling was utilised in five districts; a structured questionnaire was used to collect the information such as age, gender, education, occupation, living status, and other health related information of the participants by trained local staff; and the hepatitis B virus (HBV) infection status of the participants was determined by the chemiluminescence immunoassay test...
April 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28369186/multi-infarct-dementia-of-swedish-type-is-caused-by-a-3-utr-mutation-of-col4a1
#10
Maija Siitonen, Anne Börjesson-Hanson, Minna Pöyhönen, Ari Ora, Petra Pasanen, Jose Bras, Silke Kern, Jürgen Kern, Oluf Andersen, Horia Stanescu, Robert Kleta, Marc Baumann, Rajesh Kalaria, Hannu Kalimo, Andy Singleton, John Hardy, Matti Viitanen, Liisa Myllykangas, Rita Guerreiro
No abstract text is available yet for this article.
March 28, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28357891/earliest-memories-in-israeli-kibbutz-upbringing-it-is-parental-engagement-that-makes-a-difference
#11
Ora Aviezer, Efrat Sher-Censor, Tahel Stein-Lahad
Culture and parenting shape the ability to recall early childhood experiences. This research focused on the unique context of upbringing in the Israeli kibbutz and examined how cultural orientation and experiences of parental engagement in Kibbutz and non-Kibbutz settings shaped adults' earliest memories. Participants were 108 women (study 1) and 75 women and men (study 2) who were raised in traditional kibbutz upbringing or in a non-kibbutz family setting. In addition to reporting their earliest memory and age at earliest memory, participants estimated retrospectively the amount of daily time spent in interaction with parents, caregivers, and other children during the time of earliest memory...
March 30, 2017: Memory
https://www.readbyqxmd.com/read/28356267/hemoglobin-inhibits-albumin-uptake-by-proximal-tubule-cells-implications-for-sickle-cell-disease
#12
Megan L Eshbach, Amandeep Kaur, Youssef Rbaibi, Jesus Tejero, Ora A Weisz
Proximal tubule (PT) dysfunction, including tubular proteinuria, is a significant complication in young sickle cell disease (SCD) that can eventually lead to chronic kidney disease. Hemoglobin (Hb) dimers released from red blood cells upon hemolysis are filtered into the kidney and internalized by megalin/cubilin receptors into PT cells. The PT is especially sensitive to heme toxicity, and tubular dysfunction in SCD is thought to result from prolonged exposure to filtered Hb. Here we show that concentrations of Hb predicted to enter the tubule lumen during hemolytic crisis competitively inhibit the uptake of another megalin/cubilin ligand (albumin) by proximal tubule (PT) cells...
March 29, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28346212/stability-of-extemporaneously-prepared-hydroxycarbamide-oral-suspensions
#13
Djamila Kabiche, Issa-Bella Balde, Elyes Majoul, Sofiane Kabiche, Elodie Bourguignon, Jean-Eudes Fontan, Salvatore Cisternino, Jöel Schlatter
Hydroxycarbamide, available as tablets, is a pharmacological agent for fetal hemoglobin induction such as sickle cell anemia. The need for alternative dosage form options for patients unable to take tablets led hospital pharmacies to prepare solutions and suspensions. The objective of this study was to determine the stability of hydroxycarbamide in Ora-Plus in combination with either Ora-Sweet or Ora-Sweet SF, Ora-Blend, or Ora-Blend SF suspending agents. The studied samples were compounded into 100-mg/mL suspensions and stored in 60-mL amber glass bottles at room (22°C to 25°C) or refrigerated (4°C to 8°C) temperature...
March 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28345134/the-association-between-political-violence-and-the-connection-between-bullying-and-suicidality-among-palestinian-youth
#14
Ziad Abdeen, Anat Brunstein-Klomek, Ora Nakash, Nabil Shibli, Maayan Nagar, Hazem Agha, Sameh Hallaq, Yaniv Kanat-Maymon, Hendrik Juerges, Itzhak Levav, Radwan Qasrawi
We examined the association between protracted political violence and the connection between bullying and suicidality among Palestinian adolescents. Data were collected from a representative sample of Palestinian students (N = 5,713) from 100 schools in the West Bank and East Jerusalem who completed an in-class survey. Students who were victims of bullying or bully victims who were exposed to political violence were at higher risk for suicide attempts compared to students who were victims of bullying or bully victims but not exposed to political violence...
March 27, 2017: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/28341462/asthma-management-in-a-specialist-setting-results-of-an-italian-respiratory-society-survey
#15
Fulvio Braido, Baiardini Ilaria, Pietro Alleri, Elena Bacci, Carlo Barbetta, Michela Bellocchia, Alida Benfante, Francesco Blasi, Caterina Bucca, Maria Teresa Busceti, Stefano Centanni, Maria Cristina Colanardi, Marco Contoli, Angelo Corsico, Maria D 'Amato, Fabiano Di Marco, Dottorini Marco, Marta Ferrari, Giovanni Florio, Alessandro Giuseppe Fois, Maria Pia Foschino Barbaro, Garuti Silvia, Giuseppe Girbino, Amelia Grosso, Manuela Latorre, Sara Maniscalco, Francesco Mazza, Carlo Mereu, Giorgia Molinengo, Josuel Ora, Pierluigi Paggiaro, Vincenzo Patella, Girolamo Pelaia, Pietro Pirina, Alfio Proietto, Paola Rogliani, Pierachille Santus, Nicola Scichilone, Francesca Simioli, Paolo Solidoro, Silvia Terraneo, Umberto Zuccon, Giorgio Walter Canonica
BACKGROUND: Asthma considerably impairs patients' quality of life and increases healthcare costs. Severity, morbidity, and degree of disease control are the major drivers of its clinical and economic impact. National scientific societies are required to monitor the application of international guidelines and to adopt strategies to improve disease control and better allocate resources. AIM: to provide a detailed picture of the characteristics of asthma patients and modalities of asthma management by specialists in Italy and to develop recommendations for the daily management of asthma in a specialist setting...
March 21, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28339380/a-simplified-extemporaneously-prepared-potassium-chloride-oral-solution
#16
Elias Tannous, Yana Tal, Kamal Amarny
Although commercial preparations of oral potassium supplements are usually available, there are times when our Medical Center is faced with situations in which the oral solution of potassium chloride is not available. This solution is necessary for our pediatric outpatients who cannot swallow tablets and need an oral solution. Moreover, there are no studies available which describe an extemporaneously prepared potassium chloride oral solution on which we can rely for assigning a beyond-use date. The aim of this study was to formulate an extemporaneous pediatric oral solution of potassium chloride and to determine the physical and chemical stability of this preparation...
September 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28337056/normative-values-and-contralateral-comparison-of-anterior-chamber-parameters-measured-by-pentacam-and-its-correlation-with-corneal-biomechanical-factors
#17
Mohammad Reza Sedaghat, Vahid Mohammad Zadeh, Kaveh Fadakar, Sakineh Kadivar, Mojtaba Abrishami
PURPOSE: To evaluate the normative values of anterior chamber parameters measured by Pentacam and corneal hysteresis (CH) and corneal resistance factor (CRF) measured by Ocular Response Analyzer (ORA) and their relationship. METHODS: In an observational cross-sectional study, patients aged 18-35 years were included. Exclusion criteria were history of any intraocular or corneal disease, anomaly or surgery; hyperopic spherical refraction more than +3, and myopic spherical refraction less than -5...
January 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28333668/development-of-extemporaneously-compounded-aripiprazole-oral-suspensions-for-use-in-children
#18
Lance A Pramann, Lawrence W Davidow, Leon van Haandel, Ryan S Funk
The purpose of this study was to develop extemporaneously compounded oral liquid formulations of aripiprazole for use in pediatric patients and those patients unable to swallow the solid oral dosage forms. Aripiprazole tablets(30 mg) were ground to a fine powder and suspended at a concentration of 1.0 mg/mL in either a 1:1 blend of Ora-Plus and Ora-Sweet, or 1% methylcellulose and Simple Syrup NF. Five amber, plastic liquid prescription bottles of each formulation were stored at 4°C, and aripiprazole content was measured by ultra-performance liquid chromatography time-of-flight mass spectrometry at 0, 14, 32, 67, and 91 days...
May 2016: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28327898/adherence-to-capecitabine-in-preoperative-treatment-of-stage-ii-and-iii-rectal-cancer-do-we-need-to-worry
#19
R Font, J A Espinas, L Layos, M Martinez Villacampa, J Capdevila, M Tobeña, A Pisa, C Pericay, C Lezcano, E Fort, I Cardona, N Berga, J Solà, J M Borras
Background: Preoperative oral capecitabine plus radiotherapy has been progressively adopted in oncology units to provide more convenient care to patients with rectal cancer, but little is known about adherence to this therapy. Patients and methods: Prospective, multicentre observational study in six hospitals in metropolitan Barcelona (Spain), in patients with stage II and III rectal cancer. Assessment of adherence was based on the medical report in the clinical history, a patient questionnaire and a pill count in the pharmacy service upon finalization of treatment...
April 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28321389/host-fih-mediated-asparaginyl-hydroxylation-of-translocated-legionella-pneumophila-effectors
#20
Christopher Price, Michael Merchant, Snake Jones, Ashley Best, Juanita Von Dwingelo, Matthew B Lawrenz, Nawsad Alam, Ora Schueler-Furman, Yousef A Kwaik
FIH-mediated post-translational modification through asparaginyl hydroxylation of eukaryotic proteins impacts regulation of protein-protein interaction. We have identified the FIH recognition motif in 11 Legionella pneumophila translocated effectors, YopM of Yersinia, IpaH4.5 of Shigella and an ankyrin protein of Rickettsia. Mass spectrometry analyses of the AnkB and AnkH effectors of L. pneumophila confirm their asparaginyl hydroxylation. Consistent with localization of the AnkB effector to the Legionella-containing vacuole (LCV) membrane and its modification by FIH, our data show that FIH and its two interacting proteins, Mint3 and MT1-MMP are acquired by the LCV in a Dot/Icm type IV secretion-dependent manner...
2017: Frontiers in Cellular and Infection Microbiology
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