keyword
MENU ▼
Read by QxMD icon Read
search

ORA

keyword
https://www.readbyqxmd.com/read/29771886/-effects-of-artificial-tears-on-ocular-surface-in-glaucomatous-patients-with-long-term-instillation-of-preserved-antiglaucoma-eye-drops
#1
N V Makashova, A E Vasilieva, O Yu Kolosova
PURPOSE: To study the effects of long-term instillation of 0.18% sodium hyaluronate artificial tears VISMED multi on ocular surface in glaucomatous patients with long-term instillation of preserved anti-glaucoma drops. MATERIAL AND METHODS: The study included 79 patients (40 female and 39 male; 79 eyes in total) with primary open-angle glaucoma (POAG) divided into 3 groups according to disease stage: mild or early (stage I) glaucoma - 15 patients (15 eyes), moderate (stage II) glaucoma - 30 patients (30 eyes), advanced or severe (stage III) glaucoma - 34 patients (34 eyes)...
2018: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29764401/management-of-acute-respiratory-failure-in-interstitial-lung-diseases-overview-and-clinical-insights
#2
REVIEW
Paola Faverio, Federica De Giacomi, Luca Sardella, Giuseppe Fiorentino, Mauro Carone, Francesco Salerno, Jousel Ora, Paola Rogliani, Giulia Pellegrino, Giuseppe Francesco Sferrazza Papa, Francesco Bini, Bruno Dino Bodini, Grazia Messinesi, Alberto Pesci, Antonio Esquinas
BACKGROUND: Interstitial lung diseases (ILDs) are a heterogeneous group of diseases characterized by widespread fibrotic and inflammatory abnormalities of the lung. Respiratory failure is a common complication in advanced stages or following acute worsening of the underlying disease. Aim of this review is to evaluate the current evidence in determining the best management of acute respiratory failure (ARF) in ILDs. METHODS: A literature search was performed in the Medline/PubMed and EMBASE databases to identify studies that investigated the management of ARF in ILDs (the last search was conducted on November 2017)...
May 15, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29754800/pcyt1a-regulates-phosphatidylcholine-homeostasis-from-the-inner-nuclear-membrane-in-response-to-membrane-stored-curvature-elastic-stress
#3
Afreen Haider, Yu-Chen Wei, Koini Lim, Antonio D Barbosa, Che-Hsiung Liu, Ursula Weber, Marek Mlodzik, Kadri Oras, Simon Collier, M Mahmood Hussain, Liang Dong, Satish Patel, Anna Alvarez-Guaita, Vladimir Saudek, Benjamin J Jenkins, Albert Koulman, Marcus K Dymond, Roger C Hardie, Symeon Siniossoglou, David B Savage
Cell and organelle membranes consist of a complex mixture of phospholipids (PLs) that determine their size, shape, and function. Phosphatidylcholine (PC) is the most abundant phospholipid in eukaryotic membranes, yet how cells sense and regulate its levels in vivo remains unclear. Here we show that PCYT1A, the rate-limiting enzyme of PC synthesis, is intranuclear and re-locates to the nuclear membrane in response to the need for membrane PL synthesis in yeast, fly, and mammalian cells. By aligning imaging with lipidomic analysis and data-driven modeling, we demonstrate that yeast PCYT1A membrane association correlates with membrane stored curvature elastic stress estimates...
May 7, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29738770/involvement-of-tor-signaling-motif-in-the-regulation-of-plant-autophagy
#4
Ora Son, Sunghan Kim, Dooil Kim, Yoon-Sun Hur, Jiyoung Kim, Choong-Ill Cheon
In our previous studies, we have demonstrated that a stretch of amino-acid sequences identified from Arabidopsis ribosomal S6 kinase 1 (AtS6K1) provided a plant version of the TOS (TOR-signaling) motif, mediating the interaction with the Raptor protein in the TOR (Target of Rapamycin) kinase complex. Here we report the presence of same element in Arabidopsis Autophagy related-13 (AtATG13) protein, which is a key component of the plant autophagy response. Its composition is nearly identical to that found in the AtS6K1 in the five-amino-acid core sequence, and the presence of this five-amino-acid sequence was found to be essential for its interaction with the Raptor protein...
May 5, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29736494/oral-health-behaviour-and-oral-health-status-of-elderly-vietnamese
#5
Minh Son Nguyen, Triin Jagomägi, Ülle Voog-Oras, Toai Nguyen, Mare Saag
PURPOSE: To describe oral health behaviours and problems among elderly Vietnamese as well as determine their prevalence of caries and periodontal disease. MATERIALS AND METHODS: This cross-sectional study examined 258 elderly persons aged 65-74 years living in Danang, Vietnam. All subjects self-reported oral health behaviour and problems. Dental caries was assessed using the DMFT index. Periodontal status was evaluated with the modified Community Periodontal Index, whereby all teeth were examined for gingival bleeding and periodontal pocket depth (PPD), and the index teeth were assessed for clinical attachment loss (CAL)...
2018: Oral Health & Preventive Dentistry
https://www.readbyqxmd.com/read/29735552/hla-class-i-and-ii-diversity-contributes-to-the-etiologic-heterogeneity-of-non-hodgkin-lymphoma-subtypes
#6
Sophia S Wang, Mary Carrington, Sonja I Berndt, Susan L Slager, Paige M Bracci, Jenna Voutsinas, James R Cerhan, Karin Ekström Smedby, Henrik Hjalgrim, Joseph Vijai, Lindsay M Morton, Roel Vermeulen, Ora Paltiel, Claire M Vajdic, Martha S Linet, Alexandra Nieters, Silvia de Sanjosé, Wendy Cozen, Elizabeth E Brown, Jennifer Turner, John J Spinelli, Tongzhang Zheng, Brenda M Birmann, Christopher R Flowers, Nikolaus Becker, Elizabeth A Holly, Eleanor Kane, Dennis Weisenburger, Marc Maynadie, Pierluigi Cocco, Demetrius Albanes, Stephanie J Weinstein, Lauren R Teras, W Ryan Diver, Stephanie J Lax, Ruth C Travis, Rudolf Kaaks, Elio Riboli, Yolanda Benavente, Paul Brennan, James D McKay, Marie Helene Delfau-Larue, Brian K Link, Corrado Magnani, Maria G Ennas, Giancarlo Latte, Andrew L Feldman, Nicole Wong Doo, Graham G Giles, Melissa C Southey, Roger L Milne, Kenneth Offit, Jacob Muskinsky, Alan A Arslan, Mark P Purdue, Hans-Olov Adami, Mads Melbye, Bengt Glimelius, Lucia Conde, Nicola J Camp, Martha Glenn, Karen Curtin, Jacqueline Clavel, Alain Monnereau, David G Cox, Hervé Ghesquières, Gilles Salles, Paolo Boffetta, Lenka Foretova, Anthony Staines, Scott Davis, Richard K Severson, Qing Lan, Angela Brooks-Wilson, Martyn T Smith, Eve Roman, Anne Kricker, Yawei Zhang, Peter Kraft, Stephen J Chanock, Nathaniel Rothman, Patricia Hartge, Christine F Skibola
A growing number of loci within the human leukocyte antigen (HLA) region have been implicated in non-Hodgkin lymphoma (NHL) etiology. Here, we test a complementary hypothesis of "heterozygote advantage" regarding the role of HLA and NHL, whereby HLA diversity is beneficial and homozygous HLA loci are associated with increased disease risk. HLA alleles at class I and II loci were imputed from genome-wide association studies (GWAS) using SNP2HLA for: 3,617 diffuse large B-cell lymphomas (DLBCL), 2,686 follicular lymphomas (FL), 2,878 chronic lymphocytic leukemia/small lymphocytic lymphomas (CLL/SLL), 741 marginal zone lymphomas (MZL), and 8,753 controls of European descent...
May 7, 2018: Cancer Research
https://www.readbyqxmd.com/read/29733895/protein-peptide-docking-opportunities-and-challenges
#7
REVIEW
Maciej Ciemny, Mateusz Kurcinski, Karol Kamel, Andrzej Kolinski, Nawsad Alam, Ora Schueler-Furman, Sebastian Kmiecik
Peptides have recently attracted much attention as promising drug candidates. Rational design of peptide-derived therapeutics usually requires structural characterization of the underlying protein-peptide interaction. Given that experimental characterization can be difficult, reliable computational tools are needed. In recent years, a variety of approaches have been developed for 'protein-peptide docking', that is, predicting the structure of the protein-peptide complex, starting from the protein structure and the peptide sequence, including variable degrees of information about the peptide binding site and/or conformation...
May 4, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29723567/novel-observations-of-female-genital-anatomy-in-classic-bladder-exstrophy-using-three-dimensional-mri-reconstruction
#8
Karl S Benz, Emily Dunn, Meiyappan Solaiyappan, Mahir Maruf, Matthew Kasprenski, John Jayman, Jason E Michaud, James Facciola, John P Gearhart
PURPOSE: Understanding the distinct female anatomy in classic bladder exstrophy is crucial for optimal reconstructive and functional outcomes. This study presents novel quantitative anatomical data in females with classic bladder exstrophy prior to primary closure. MATERIALS AND METHODS: Patients underwent three-dimensional reconstruction of pelvic magnetic resonance imaging studies, and pelvic anatomy was characterized, including measurements of the vagina, cervix, and erectile bodies...
April 30, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29716427/the-safety-of-dual-bronchodilation-on-cardiovascular-serious-adverse-events-in-copd
#9
Paola Rogliani, Josuel Ora, Maria Gabriella Matera, Mario Cazzola, Luigino Calzetta
Introduction Long-acting β2 -adrenoceptor (β2 -AR) agonists (LABAs) plus long-acting muscarinic antagonists (LAMAs) is the cornerstone for treating chronic obstructive pulmonary disease (COPD). LABA/LAMA combinations elicit clinical and functional synergistic interaction, and such an interaction should permit to reduce the dose of each monocomponent in the drug mixture to minimize the risk of adverse events (AEs). Overall, currently available LABA/LAMA fixed-dose combinations (FDCs) combine the drugs at the same doses of formulations designed for a single drug...
May 1, 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29708993/alcohol-use-abuse-and-dependence-in-an-older-european-population-results-from-the-mentdis_icf65-study
#10
Manuel Muñoz, Berta Ausín, Ana B Santos-Olmo, Martin Härter, Jana Volkert, Holger Schulz, Susanne Sehner, Maria Christina Dehoust, Anna Suling, Karl Wegscheider, Alessandra Canuto, Mike J Crawford, Luigi Grassi, Chiara Da Ronch, Yael Hershkovitz, Alan Quirk, Ora Rotenstein, Arieh Y Shalev, Jens Strehle, Kerstin Weber, Hans-Ulrich Wittchen, Sylke Andreas
BACKGROUND: Alcohol use disorders (AUD) in older people have been the subject of increasing interest in Europe and worldwide. However, thus far, no reliable data exist regarding the prevalence of AUD in people over the age of 65 years in Europe. OBJECTIVE: To assess the current (past month), 12-month and lifetime prevalence of alcohol use, abuse and dependence in people aged 65-84 years. STUDY DESIGN: The MentDis_ICF65+ study was a representative stepwise cross-sectional survey that was conducted in six European and associated cities (Hamburg, Germany; Ferrara, Italy; London/Canterbury, England; Madrid, Spain; Geneva, Switzerland and Jerusalem, Israel)...
2018: PloS One
https://www.readbyqxmd.com/read/29708773/efficacy-of-the-fun-for-wellness-online-intervention-to-promote-well-being-actions-a-secondary-data-analysis
#11
Nicholas D Myers, Samantha Dietz, Isaac Prilleltensky, Ora Prilleltensky, Adam McMahon, Carolyn L Rubenstein, Seungmin Lee
OBJECTIVE: Fun For Wellness (FFW) is a new online intervention designed to promote growth in well-being by providing capability-enhancing learning opportunities (e.g., play an interactive game) to participants. The purpose of this study was to provide an initial evaluation of the efficacy of the FFW intervention to increase well-being actions. MATERIALS AND METHODS: The study design was a secondary data analysis of a large-scale prospective, double-blind, parallel-group randomized controlled trial...
April 30, 2018: Games for Health
https://www.readbyqxmd.com/read/29702689/wheezing-phenotypes-and-risk-factors-in-early-life-the-elfe-cohort
#12
Souheil Hallit, Benedicte Leynaert, Marie Christine Delmas, Steffi Rocchi, Jacques De Blic, Christophe Marguet, Emeline Scherer, Marie Noelle Dufourg, Corinne Bois, Gabriel Reboux, Laurence Millon, Marie Aline Charles, Chantal Raherison
OBJECTIVE: Different phenotypes of wheezing have been described to date but not in early life. We aim to describe wheezing phenotypes between the ages of two months and one year, and assess risk factors associated with these wheezing phenotypes in a large birth cohort. METHODS: We studied 18,041 infants from the ELFE (French Longitudinal Study of Children) birth cohort. Parents reported wheezing and respiratory symptoms at two and 12 months, and answered a complete questionnaire (exposure during pregnancy, parental allergy)...
2018: PloS One
https://www.readbyqxmd.com/read/29699983/correspondence-between-retinotopic-cortical-mapping-and-conventional-functional-and-morphological-assessment-of-retinal-disease
#13
Markus Ritter, Allan Hummer, Anna A Ledolter, Graham E Holder, Christian Windischberger, Ursula M Schmidt-Erfurth
PURPOSE: The present study describes retinotopic mapping of the primary visual cortex using functional MRI (fMRI) in patients with retinal disease. It addresses the relationship between fMRI data and data obtained by conventional assessment including microperimetry (MP) and structural imaging. METHODS: Initial testing involved eight patients with central retinal disease (Stargardt disease, STGD) and eight with peripheral retinal disease (retinitis pigmentosa, RP), who were examined using fMRI and MP (Nidek MP-1)...
April 26, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29698559/tuftsin-phosphorylcholine-tpc-equally-effective-to-methylprednisolone-in-ameliorating-lupus-nephritis-in-a-mice-model
#14
Asaf Shemer, Shay Kivity, Ora Shovman, Ori Perry, Abdulla Watad, Dana Ben-Ami Shor, Alex Volkov, Iris Barshack, Nicola L Bragazzi, Alexander Krule, Mati Fridkin, Howard Amital, Miri Blank, Yehuda Shoenfeld
BACKGROUND: The role of helminth treatment in autoimmune diseases is constantly growing. Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease with challenging treatment options. Tuftsin phosphorylcholine (TPC) is a novel helminth-based compound that modulates the host immune network. OBJECTIVES: This study was conducted to evaluate the potential value of TPC in ameliorating lupus nephritis in a murine model and specifically to compare the efficacy of TPC to the existing first-line therapy for SLE: corticosteroids (methylprednisolone)...
April 26, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29691267/stability-of-extemporaneously-prepared-cinacalcet-oral-suspensions
#15
Kara Thomson, David J Hutchinson, Lipika Chablani
PURPOSE: The stability of extemporaneously prepared cinacalcet suspensions over 90 days was evaluated. METHODS: Cinacalcet 5-mg/mL suspension was prepared by triturating 30-mg cinacalcet tablets. Twelve 30-mL batches were prepared with a 1:1 mixture of Ora-Plus and either Ora-Sweet or Ora-Sweet SF (sugar free). Three suspensions of each kind were stored at both room temperature and refrigerated conditions. A 1-mL sample was taken from each bottle at 0, 7, 18, 32, 64, and 90 days...
May 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29671866/isocapnic-hyperventilation-provides-early-extubation-after-head-and-neck-surgery-a-prospective-randomized-trial
#16
K Hallén, P Jildenstål, O Stenqvist, J Oras, S-E Ricksten, S Lindgren
BACKGROUND: Isocapnic hyperventilation (IHV) shortens recovery time after inhalation anaesthesia by increasing ventilation while maintaining a normal airway carbon dioxide (CO2 )-level. One way of performing IHV is to infuse CO2 to the inspiratory limb of a breathing circuit during mechanical hyperventilation (HV). In a prospective randomized study, we compared this IHV technique to a standard emergence procedure (control). METHODS: Thirty-one adult ASA I-III patients undergoing long-duration (>3 hours) sevoflurane anaesthesia for major head and neck surgery were included and randomized to IHV-treatment (n = 16) or control (n = 15)...
April 19, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29664551/socio-demographic-and-psychological-determinants-of-exclusive-breastfeeding-after-six-months-postpartum-a-polish-case-cohort-study
#17
Karolina Maria Maliszewska, Mariola Bidzan, Małgorzata Świątkowska-Freund, Krzysztof Preis
OBJECTIVES: The purpose of this study was to explore the socio-demographic and psychological factors connected with exclusive breastfeeding after 6 months postpartum. MATERIAL AND METHODS: A total of 251 women filled in questionnaires in the first week postpartum, then again after 3 and 6 months. The questionnaires included socio-demographic and medical questions, as well as psychological tools: the NEO-FFI Personality Inventory, the Berlin Social Support Scales (BSSS), and the Edinburgh Postnatal Depression Scale (EPDS)...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29659170/association-of-peripheral-blood-leukocyte-kibra-methylation-with-gastric-cancer-risk-a-case-control-study
#18
Yan Zhang, Haibo Zhou, Hongxu Sun, Jie Chen, Di Huang, Xu Han, Xiyun Ren, Shangqun Lin, Qing Fan, Wenjing Tian, Yashuang Zhao
KIBRA was reported to be involved in various types of cancer and can be detected in blood. The purpose of this study was to investigate the relationship between the status of KIBRA methylation in peripheral blood leukocytes and gastric cancer (GC) risk. A case-control study was carried out to evaluate the association of blood cell-derived KIBRA methylation with the risk of GC using methylation-sensitive high-resolution melting analysis. A total of 393 cases and 393 controls were detected, respectively. Compared with the subjects in the KIBRA negative methylation (NM) group, positive methylation (PM) subjects exhibited a 1...
April 16, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29651044/yeast-aconitase-mitochondrial-import-is-modulated-by-interactions-of-its-c-and-n-terminal-domains-and-ssa1-2-hsp70
#19
Reut Ben-Menachem, Katherine Wang, Orly Marcu, Zhang Yu, Teck Kwang Lim, Qingsong Lin, Ora Schueler-Furman, Ophry Pines
Molecules of single proteins, echoforms, can be distributed between two (or more) subcellular locations, a phenomenon which we refer to as dual targeting or dual localization. The yeast aconitase gene ACO1 (778 amino acids), encodes a single translation product that is nonetheless dual localized to the cytosol and mitochondria by a reverse translocation mechanism. The solved crystal structure of aconitase isolated from porcine heart mitochondria shows that it has four domains. The first three tightly associated N-terminal domains are tethered to the larger C-terminal fourth domain (C-terminal amino acids 517-778)...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29643950/higher-intraocular-pressure-levels-associated-with-lower-hysteresis-in-type-2-diabetes
#20
Sinan Bekmez, Tolga Kocaturk
Aim: To investigate the differences of corneal biomechanic characteristics using Ocular Response Analyzer (ORA, Reichert; USA) on type 2 diabetics and healthy subjects. Methods: One hundred eyes of 100 subjects (between the ages of 17-91) who applied to Adnan Menderes University's Ophthalmology Clinic between January-March 2015 were included in this study, 50 diabetics (Group 1) and 50 healthy controls (Group 2). The eyes included in the study were randomly chosen...
2018: Open Ophthalmology Journal
keyword
keyword
89354
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"