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https://www.readbyqxmd.com/read/29326482/compounded-apixaban-suspensions-for-enteral-feeding-tubes
#1
Maria L Caraballo, Seda Donmez, Kobi Nathan, Fang Zhao
Objective: There is limited information on compounded apixaban formulations for administration via enteral feeding tubes. This study was designed to identify a suitable apixaban suspension formulation that is easy to prepare in a pharmacy setting, is compatible with commonly used feeding tubes, and has a beyond-use date of 7 days. Methods: Apixaban suspensions were prepared from commercially available 5-mg Eliquis tablets. Several vehicles and compounding methods were screened for ease of preparation, dosage accuracy, and tube compatibility...
July 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/29322692/patient-characteristics-associated-with-treatment-response-in-patients-receiving-salvianolate-injection-for-stable-angina
#2
Yana Qi, Chuan Yu, Li Tang, Sheyu Li, Xin Sun
OBJECTIVE: To explore patient characteristics associated with treatment response in patients receiving salvianolate injection for stable angina. METHODS: An analysis was conducted of data from a multicenter, phase IV clinical trial undertaken in China that enrolled 2150 patients hospitalized for stable angina from 50 hospitals. The treatment outcomes were changes of angina severity and nitroglycerin use between baseline and the last day of treatment. We used logistic regression models to explore patient characteristics associated with the treatment response...
January 11, 2018: Journal of Evidence-based Medicine
https://www.readbyqxmd.com/read/29321641/antiphospholipid-syndrome
#3
REVIEW
Karen Schreiber, Savino Sciascia, Philip G de Groot, Katrien Devreese, Soren Jacobsen, Guillermo Ruiz-Irastroza, Jane E Salmon, Yehuda Shoenfeld, Ora Shovman, Beverley J Hunt
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence of antiphospholipid antibodies, such as lupus anticoagulant, anticardiolipin antibodies and anti-β2-glycoprotein 1 antibodies. APS can present with a variety of clinical phenotypes, including thrombosis in the veins, arteries and microvasculature as well as obstetrical complications. The pathophysiological hallmark is thrombosis, but other factors such as complement activation might be important. Prevention of thrombotic manifestations associated with APS includes lifestyle changes and, in individuals at high risk, low-dose aspirin...
January 11, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29307123/the-role-of-diet-in-managing-inflamatory-bowel-disease-affected-dogs-a-retrospective-cohort-study-on-76-cases
#4
Maria Chiara Marchesi
The term in ammatory bowel diseases (IBD) refers to a group of idiopathic, chronic intestinal diseases characterized by a di use in ltration of in ammatory cells into the lamina propria of the intestine. The pathogenesis of IBD is unknown. The most common signs described are diarrhoea, vomit, and progressive weight loss. In order to make a de nitive diagnosis, though, the presence of in ammatory cells in ltration must be evident on histopathologic analysis. The therapeutic approach has 2 main goals: decrease the in ammatory response and remove possible antigenic sources, such as food components or intestinal micro ora...
December 29, 2017: Veterinaria Italiana
https://www.readbyqxmd.com/read/29305310/a-prospective-longitudinal-study-to-investigate-corneal-hysteresis-as-a-risk-factor-for-predicting-development-of-glaucoma
#5
Carolina N Susanna, Alberto Diniz-Filho, Fábio B Daga, Bianca N Susanna, Feilin Zhu, Nara G Ogata, Felipe A Medeiros
PURPOSE: To investigate the role of corneal hysteresis (CH) as a risk factor for development of glaucoma. DESIGN: Prospective observational cohort study. METHODS: Two-hundred and eighty-seven eyes of 199 patients suspected of having glaucoma followed for an average of 3.9 ± 1.8 years. All eyes had normal visual fields at baseline. Development of glaucoma was defined as occurrence of 3 consecutive abnormal standard automated perimetry tests during follow-up, defined as pattern standard deviation (PSD) <5%, and/or Glaucoma Hemifield Test outside normal limits...
January 2, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29290423/erratum-to-patterns-of-fgf-23-dmp1-and-mepe-expression-in-patients-with-chronic-kidney-disease-bone-45-6-2009-1161-1168
#6
Renata C Pereira, Harald Jűppner, Carlos E Azucena-Serrano, Ora Yadin, Isidro B Salusky, Katherine Wesseling-Perry
No abstract text is available yet for this article.
December 28, 2017: Bone
https://www.readbyqxmd.com/read/29289968/screening-for-maternal-postpartum-depression-and-associationswith-personality-traits-and-social-support-a-polish-follow-upstudy-4-weeks-and-3-months-after-delivery
#7
Karolina Maliszewska, Małgorzata Świątkowska-Freund, Mariola Bidzan, Preis Krzysztof
OBJECTIVES: To investigate the likelihood of postpartum depression and to explore maternal characteristics in terms of personality, social support and other medical and psychological data. METHODS: A sample of 548 patients was investigated 4 weeks and 3 months after delivery. They responded to questionnaires containing sociodemographic questions: the EPDS (Edinburgh Postnatal Depression Scale), the PHQ-9 (Patient Health Questionnaire-9), theNEO-FFI (Personality Inventory), and the BSSS (Berlin Social Support Scales)...
October 29, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/29286377/the-organoid-reconstitution-assay-ora-for-the-functional-analysis-of-intestinal-stem-and-niche-cells
#8
Matthias Schewe, Andrea Sacchetti, Mark Schmitt, Riccardo Fodde
The intestinal epithelium is characterized by an extremely rapid turnover rate. In mammals, the entire epithelial lining is renewed within 4 - 5 days. Adult intestinal stem cells reside at the bottom of the crypts of Lieberkühn, are earmarked by expression of the Lgr5 gene, and preserve homeostasis through their characteristic high proliferative rate1. Throughout the small intestine, Lgr5+ stem cells are intermingled with specialized secretory cells called Paneth cells. Paneth cells secrete antibacterial compounds (i...
November 20, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29283679/influence-of-short-term-orthokeratology-to-corneal-tangent-modulus-a-randomized-study
#9
Andrew Kc Lam, Stanley Yy Leung, Ying Hon, Lu Shu-Ho, Kit-Ying Wong, Pui-Kwan Tiu, David Cc Lam
PURPOSE: Influence of orthokeratology on corneal biomechanics is equivocal using Ocular Response Analyzer, ORA. Implementing indentation method, corneal tangent modulus was measured and monitored in short-term orthokeratology. MATERIALS AND METHODS: Sixteen young subjects with refractive errors between -4D to -5D sphere and astigmatism within -1.50D were recruited. One randomly selected eye wore orthokeratology lens (treatment), and the fellow eye wore conventional rigid gas permeable lens (control)...
December 28, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29281622/high-resolution-global-peptide-protein-docking-using-fragments-based-piper-flexpepdock
#10
Nawsad Alam, Oriel Goldstein, Bing Xia, Kathryn A Porter, Dima Kozakov, Ora Schueler-Furman
Peptide-protein interactions contribute a significant fraction of the protein-protein interactome. Accurate modeling of these interactions is challenging due to the vast conformational space associated with interactions of highly flexible peptides with large receptor surfaces. To address this challenge we developed a fragment based high-resolution peptide-protein docking protocol. By streamlining the Rosetta fragment picker for accurate peptide fragment ensemble generation, the PIPER docking algorithm for exhaustive fragment-receptor rigid-body docking and Rosetta FlexPepDock for flexible full-atom refinement of PIPER docked models, we successfully addressed the challenge of accurate and efficient global peptide-protein docking at high-resolution with remarkable accuracy, as validated on a small but representative set of peptide-protein complex structures well resolved by X-ray crystallography...
December 27, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29276255/in-vitro-evaluation-of-eslicarbazepine-delivery-via-enteral-feeding-tubes
#11
Kristin Reindel, Fang Zhao, Susan Hughes, Vivek S Dave
Purpose: The feasibility of preparing an eslicarbazepine acetate suspension using Aptiom tablets for administration via enteral feeding tubes was evaluated. Methods: Eslicarbazepine acetate suspension (40 mg/mL) was prepared using Aptiom tablets after optimizing the tablet crushing methods and the vehicle composition. A stability-indicating high-performance liquid chromatography (HPLC) method was developed to monitor the eslicarbazepine stability in the prepared suspension. Three enteric feeding tubes of various composition and dimensions were evaluated for the delivery of the suspensions...
December 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/29258480/end-of-life-care-preferences-among-people-of-advanced-age-lilacs-nz
#12
Merryn Gott, Rosemary Frey, Janine Wiles, Anna Rolleston, Ruth Teh, Tess Moeke-Maxwell, Ngaire Kerse
BACKGROUND: Understanding end of life preferences amongst the oldest old is crucial to informing appropriate palliative and end of life care internationally. However, little has been reported in the academic literature about the end of life preferences of people in advanced age, particularly the preferences of indigenous older people, including New Zealand Māori. METHODS: Data on end of life preferences were gathered from 147 Māori (aged >80 years) and 291 non- Māori aged (>85 years), during three waves of Te Puawaitangi O Nga Tapuwae Kia Ora Tonu, Life and Living in Advanced Age (LiLACs NZ)...
December 19, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/29251401/corneal-hysteresis-and-anterior-segment-optical-coherence-tomography-anatomical-parameters-in-primary-angle-closure-suspects
#13
Syed Amal Hussnain, Kyle D Kovacs, Joshua L Warren, Christopher C Teng
IMPORTANCE: Corneal hysteresis (CH) is a dynamic marker of structural and functional changes in the cornea associated with IOP and central corneal thickness, but its utility in assessing primary angle closure suspects (PACS) has not been fully elucidated. BACKGROUND: This study assesses if anterior segment measurements correlate with CH in PACS patients. DESIGN: IRB-approved retrospective review of imaging and records at a university practice...
December 18, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29245582/review-of-australian-i-scirtes-i-illiger-ora-clark-and-i-exochomoscirtes-i-pic-coleoptera-scirtidae-including-descriptions-of-new-species-new-groups-and-a-multi-gene-molecular-phylogeny-of-australian-and-non-australian-species
#14
Chris H S Watts, Steven J B Cooper, Kathleen M Saint
The phylogenetic relationships of 26 Australian species of Scirtes Illiger, Ora Clark and Exochomoscirtes Pic (Scirtidae) were investigated using adult morphology, particularly male and female genitalia, larval morphology and molecular data from the mitochondrial cytochrome c oxidase subunit I (COI) gene and the nuclear genes elongation factor 1-alpha (EF1- a) and topoisomerase I (TOP1). Four species of Scirtes and one of Ora from Europe, Southeast Asia and Japan were included. The genus Scirtes is shown to be paraphyletic with respect to the genera Ora and Exochomoscirtes...
November 14, 2017: Zootaxa
https://www.readbyqxmd.com/read/29242184/sex-differences-in-treatments-relative-survival-and-excess-mortality-following-acute-myocardial-infarction-national-cohort-study-using-the-swedeheart-registry
#15
Oras A Alabas, Chris P Gale, Marlous Hall, Mark J Rutherford, Karolina Szummer, Sofia Sederholm Lawesson, Joakim Alfredsson, Bertil Lindahl, Tomas Jernberg
BACKGROUND: This study assessed sex differences in treatments, all-cause mortality, relative survival, and excess mortality following acute myocardial infarction. METHODS AND RESULTS: A population-based cohort of all hospitals providing acute myocardial infarction care in Sweden (SWEDEHEART [Swedish Web System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies]) from 2003 to 2013 was included in the analysis...
December 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29232333/structural-analysis-and-comprehensive-surgical-outcomes-of-the-sutureless-intrascleral-fixation-of-secondary-intraocular-lenses-in-human-eyes
#16
Bozho Todorich, Maxwell S Stem, Keshav Kooragayala, Aristomenis Thanos, Lisa J Faia, George A Williams, Tarek S Hassan, Maria A Woodward, Jeremy D Wolfe
PURPOSE: To describe surgical outcomes and structural characteristics of intraocular lenses (IOLs) implanted with transconjunctival sutureless intrascleral (SIS) fixation in human eyes. DESIGN: Retrospective interventional surgical case series involving live and cadaveric human eyes. METHODS: In this study, we investigated the surgical outcomes and structural anatomy of secondary IOLs implanted with the SIS technique in human eyes. All cases involving SIS IOL fixation performed at a single academic center from January 1, 2012, through July 30, 2016, were reviewed to describe the surgical technique, common indications, clinical outcomes, and the rate of common operative complications...
December 11, 2017: Retina
https://www.readbyqxmd.com/read/29223928/are-there-risk-factors-for-false-positive-malformation-diagnoses-on-obstetric-ultrasound-a-nested-case-control-study
#17
A Debost-Legrand, I Perthus, O Rivière, D Gallot, D Lémery, F Vendittelli
INTRODUCTION: In a population-based study, we found an overall false-positive rate of 8.8% for the second and third trimester ultrasounds. Although numerous studies have been performed to examine factors which lead to false negatives, the same is not true for the factors associated with false positives. The principal objective of this study was to look for risk factors for false-positive diagnoses of fetal malformations on obstetric ultrasound scans. MATERIAL AND METHODS: In this nested case-control study, the case infants were those whose mother had a false-positive antenatal ultrasound diagnosis of a malformation during the second or third trimester (ultrasound false-positives) and who were live- or stillborn in Auvergne in 2006-2010...
December 6, 2017: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29222363/stability-of-a-pyrimethamine-suspension-compounded-from-bulk-powder
#18
Paul O Lewis, David B Cluck, Jessica D Huffman, Amanda P Ogle, Stacy D Brown
PURPOSE: Development of a stability-indicating high-performance liquid chromatography (HPLC) method for pyrimethamine analysis, with subsequent application of that method to assess the 90-day stability of a pyrimethamine suspension compounded from bulk USP-grade pyrimethamine powder, is described. METHODS: A stability-indicating method of HPLC with ultraviolet detection specific to pyrimethamine was developed according to pharmacopeial recommendations and validated...
December 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29199986/a-low-cost-method-for-visible-fluorescence-imaging
#19
Crissy L Tarver, Marc Pusey
A wide variety of crystallization solutions are screened to establish conditions that promote the growth of a diffraction-quality crystal. Screening these conditions requires the assessment of many crystallization plates for the presence of crystals. Automated systems for screening and imaging are very expensive. A simple approach to imaging trace fluorescently labeled protein crystals in crystallization plates has been devised, and can be implemented at a cost as low as $50. The proteins β-lactoglobulin B, trypsin and purified concanavalin A (ConA) were trace fluorescently labeled using three different fluorescent probes: Cascade Yellow (CY), Carboxyrhodamine 6G (CR) and Pacific Blue (PB)...
December 1, 2017: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/29198254/predisposing-enabling-and-need-factors-of-service-utilization-in-the-elderly-with-mental-health-problems
#20
Jana Volkert, Sylke Andreas, Martin Härter, Maria Christina Dehoust, Susanne Sehner, Anna Suling, Berta Ausín, Alessandra Canuto, Mike J Crawford, Chiara Da Ronch, Luigi Grassi, Yael Hershkovitz, Manuel Muñoz, Alan Quirk, Ora Rotenstein, Ana Belén Santos-Olmo, Arieh Y Shalev, Jens Strehle, Kerstin Weber, Karl Wegscheider, Hans-Ulrich Wittchen, Holger Schulz
BACKGROUND: Empirical data on the use of services due to mental health problems in older adults in Europe is lacking. The objective of this study is to identify factors associated with service utilization in the elderly. METHODS: As part of the MentDis_ICF65+ study, N = 3,142 people aged 65-84 living in the community in six European and associated countries were interviewed. Based on Andersen's behavioral model predisposing, enabling, and need factors were analyzed with logistic regression analyses...
December 4, 2017: International Psychogeriatrics
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