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https://www.readbyqxmd.com/read/29471591/improvement-of-life-quality-measured-by-lansky-score-after-enzymatic-replacement-therapy-in-children-with-gaucher-disease-type-1
#1
Magdalena Cerón-Rodríguez, Edgar Barajas-Colón, Lyuva Ramírez-Devars, Claudia Gutiérrez-Camacho, Juan L Salgado-Loza
BACKGROUND: Gaucher disease type 1 (GD1, OMIM# 230800), is a condition with high impact in patient's quality of life (QoL). We report the improvement in QoL of children with GD1 measured by Lansky play-performance scale (LS) after enzymatic replacement therapy (ERT) and to describe our experience in the treatment of children with GD1. METHODS: Five children with diagnosis of GD1 received imiglucerase 60 mg/kg every two weeks. LS, hepatomegaly, splenomegaly, hemoglobin, platelets, and growth rate were measured every 6 months after beginning ERT for 30 months...
January 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29471574/-type-2-diabetes-diabetes-in-older-adults-example-for-patient-centered-drug-therapy
#2
Dirk Müller-Wieland
Diabetes in older adults has a high prevalence and is frequently associated with comorbidities of the cardiovascular system, dysfunction of cognition as well as depression and impaired mobility or increased frailty. Furthermore, impaired renal function, heart failure, risk for hypoglycemia and polypharmacy has to be considered in the decision about the diabetes treatment strategy. The goal of blood glucose management is driven by patient relevant issues and patient self-esteem, quality of life defined by the patient, preservation of physical and social mobility rather than potential long-term effects on reduction of cardio- and microvascular events in the future, which is limited by patient-inherent reduced life expectancy of the aged individual...
February 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29471498/-it-was-the-best-worst-day-of-my-life-narrative-content-structure-and-process-in-wisdom-fostering-life-event-memories
#3
Nic M Weststrate, Michel Ferrari, Marc A Fournier, Kate C McLean
Objectives: The purpose of this study was to examine laypeople's subjective understanding of their own wisdom development. To do this, autobiographical memories of wisdom-fostering life events were examined for (a) life-event characteristics, and (b) self-reflective processes believed to support growth in wisdom through life experience. Methods: Midlife adults (N = 482) provided a written autobiographical memory of a wisdom-fostering life event. Memories were content analyzed by expert coders for life-event characteristics (i...
February 20, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29471267/the-effectiveness-of-traditional-chinese-medicine-based-lifestyle-interventions-on-biomedical-psychosocial-and-behavioral-outcomes-in-individuals-with-type-2-diabetes-a-systematic-review-with-meta-analysis
#4
REVIEW
Xingfeng Yu, Janita P C Chau, Lanting Huo
BACKGROUND: Integrative diabetes care, which combines conventional diabetes therapy with traditional Chinese medicine (TCM)-based interventions, has gained popularity worldwide. Numerous TCM-based lifestyle modification approaches have been proposed for individuals with type 2 diabetes (T2DM). OBJECTIVES: To synthesize and present the best available evidence on the effectiveness of TCM-based lifestyle interventions in individuals with T2DM. DESIGN: We undertook a systematic review of randomized controlled trials or controlled clinical trials...
February 19, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29471180/linking-financial-hardship-throughout-the-life-course-with-psychological-distress-in-old-age-sensitive-period-accumulation-of-risks-and-chain-of-risks-hypotheses
#5
Alexander Darin-Mattsson, Ross Andel, Roger Keller Celeste, Ingemar Kåreholt
The primary objective was to investigate the life course hypotheses - sensitive period, chain of risks, and accumulation of risks - in relation to financial hardship and psychological distress in old age. We used two Swedish longitudinal surveys based on nationally representative samples. The first survey includes people 18-75 years old with multiple waves, the second survey is a longitudinal continuation, including people 76 + years old. The analytical sample included 2990 people at baseline. Financial hardship was assessed in childhood (retrospectively), at the mean ages of 54, 61, 70, and 81 years...
February 17, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29471082/anhedonic-behavior-and-%C3%AE-amino-butyric-acid-during-a-sensitive-period-in-female-rats-exposed-to-early-adversity
#6
Jodi L Lukkes, Shirisha Meda, Kevin J Norman, Susan L Andersen
Early life adversity increases depressive behavior that emerges during adolescence. Sensitive periods have been associated with fewer GABAergic interneurons, especially parvalbumin (PV), brain derived growth factor, and its receptor, TrkB. Here, maternal separation (MS) and social isolation (ISO) were used to establish a sensitive period for anhedonic depression using the learned helplessness (LH) paradigm. Female Sprague-Dawley rat pups underwent MS for 4-h/day or received typical care (CON) between postnatal days 2-20; for the ISO condition, separate cohorts were individually housed between days 20-40 or served as controls (CON2)...
February 13, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29470730/sacral-nerve-stimulation-versus-percutaneous-tibial-nerve-stimulation-for-faecal-incontinence-a-systematic-review-and-meta-analysis
#7
Constantinos Simillis, Nikhil Lal, Shengyang Qiu, Christos Kontovounisios, Shahnawaz Rasheed, Emile Tan, Paris P Tekkis
AIMS: Percutaneous tibial nerve stimulation (PTNS) and sacral nerve stimulation (SNS) are both second-line treatments for faecal incontinence (FI). To compare the clinical outcomes and effectiveness of SNS versus PTNS for treating FI in adults. METHOD: A literature search of MEDLINE, Embase, Science Citation Index Expanded and Cochrane was performed in order to identify studies comparing SNS and PTNS for treating FI. A risk of bias assessment was performed using The Cochrane Collaboration's risk of bias tool...
February 22, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29470713/health-related-quality-of-life-in-patients-undergoing-cervico-thoracic-osteotomies-for-fixed-cervico-thoracic-kyphosis-in-patients-with-ankylosing-spondylitis
#8
Silviu Sabou, Hossein Mehdian, Dritan Pasku, Luca Boriani, Nasir A Quraishi
PURPOSE: Ankylosing spondylitis (AS) can result in severe cervico-thoracic kyphotic deformity (CTKD). Few studies have addressed the relationship between cervico-thoracic osteotomies in AS and health-related quality of life scores. The aim of this study is to evaluate the impact of cervico-thoracic osteotomy (CTO) on improving quality of life for patients with fixed CTKD. METHODS: A database of all patients who underwent a CTO for CTKD in patients with AS was created...
February 22, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29470573/factors-associated-with-health-related-quality-of-life-in-medically-and-surgically-treated-patients-with-glaucoma
#9
Cheryl L Khanna, David A Leske, Jonathan M Holmes
Importance: Health-related quality of life (HRQOL) is often reduced with glaucoma, but associated factors are poorly understood. Objective: To determine factors associated with reduced HRQOL in medically and surgically treated patients with glaucoma. Design, Setting, and Participants: Prospective cohort study at a tertiary referral glaucoma practice, with 160 consecutive, prospectively enrolled medically or surgically treated adult patients with glaucoma...
February 22, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29470565/sociodemographic-medical-and-psychosocial-factors-associated-with-supportive-care-needs-in-adults-diagnosed-with-uveal-melanoma
#10
Timothy J Williamson, Alexandra Jorge-Miller, Tara A McCannel, Tammy M Beran, Annette L Stanton
Importance: Understanding supportive care needs in patients with cancer is important for developing approaches that enhance quality of life and promote satisfaction with care. Objective: To characterize the nature and frequency of sociodemographic, medical, and psychosocial factors associated with unmet needs in patients with uveal melanoma 1 week and 3 months after diagnosis. Design, Setting, and Participants: This 3-month, prospective, longitudinal survey study was conducted at a university-based ophthalmology practice from June 1, 2007, to July 1, 2011...
February 22, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29470472/ethnic-and-sex-related-differences-in-pain-characteristics-psychological-distress-and-pain-related-disability-in-patients-attending-a-new-zealand-teaching-hospital-pain-service
#11
Andrea Burri, David Rice, Nicola Kluger, Michal Kluger
AIM: The aim of the present observational study was to provide a description of the demographic, psychological and pain characteristics of patients attending the Waitemata Pain Services (WPS), Auckland, New Zealand. METHOD: Data were collected via a comprehensive paper-pencil questionnaire handed out to 798 consecutive new patients seen at the WPS over a four-year period. RESULTS: 32.3% attending the WPS were men and 67.7% women, with a mean age of 52...
February 23, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29470313/injustice-perceptions-about-pain-parent-child-discordance-is-associated-with-worse-functional-outcomes
#12
Megan M Miller, David Wuest, Amy E Williams, Eric L Scott, Zina Trost, Adam T Hirsh
Pain is experienced in and influenced by social environments. For children with chronic pain, the child-parent relationship and parental beliefs about pain are particularly important and may influence pain outcomes. Pain-related injustice perceptions have recently been identified as an important cognitive-emotional factor for children with pain. The current study aimed to better understand the pain-related injustice perceptions of children with chronic pain and their parents. The sample consisted of 253 pediatric chronic pain patients (mean age=14...
February 20, 2018: Pain
https://www.readbyqxmd.com/read/29470290/autoimmune-hepatitis-in-children-and-adolescents-effect-on-quality-of-life
#13
Isadora de Carvalho Trevizoli, Carolina Silva Pinedo, Vanessa Oliveira Teles, Renata Belém Pessoa de Melo Seixas, Elisa de Carvalho
OBJECTIVES: The aim of the to evaluate the effect of autoimmune hepatitis (AIH) on the quality of life of children and adolescents and to identify which variables effect health-related quality of life (HRQoL). METHODS: The Pediatric Quality of Life Inventory 4.0 (PedsQL 4.0) was used to evaluate HRQoL. In addition, a questionnaire was applied which included signs, symptoms, and use of medications. RESULTS: A total of 43 patients (mean age, 15...
February 21, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29470277/does-duration-of-pain-at-baseline-influence-clinical-outcomes-of-low-back-pain-patients-managed-on-an-evidence-based-pathway
#14
Mary-Anne Jess, Ryan Cormac, Sharon Hamilton, Shaun Wellburn, Greg Atkinson, Charles Greenough, Andrew Coxon, Diarmaid Ferguson, Francis Fatoye, John Dickson, Andrea Jones, Denis Martin
Supplemental Digital Content is available in the text STUDY DESIGN.: Longitudinal observational study. OBJECTIVE: To investigate the association between the duration of pain at baseline and the clinical outcomes of patients with low back pain (LBP) enrolled on the North East of England Regional Back Pain and Radicular Pain Pathway (NERBPP). SUMMARY OF BACKGROUND DATA: The NERBPP is a clinical pathway based upon NICE guidelines (2009) for LBP of <1-year duration...
February 21, 2018: Spine
https://www.readbyqxmd.com/read/29470097/a-novel-minimally-invasive-method-of-successful-tissue-glue-injection-in-patients-with-iatrogenic-pseudoaneurysm
#15
Jacek Kurzawski, Agieszka Janion-Sadowska, Marcin Sadowski
OBJECTIVE: To investigate the efficacy and safety of ultrasound-guided tissue glue injection for the treatment of iatrogenic femoral artery pseudoaneurysm. METHODS: The study comprised of nine patients with unsuccessful ultrasound-guided thrombin injection and one patient with rapidly progressing anaemia. All patients had undergone recanalization procedures at least twice, including two subjects with a very rapidly enlarging pseudoaneurysm lobe or significant anaemia...
February 22, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29469999/a-systematic-review-and-meta-analysis-of-baseline-ohip-edent-scores
#16
J M J Duale, Y A Patel, J Wu, T P Hyde
BACKGROUND: OHIP-EDENT is widely used in the literature to assess Oral-Health-Related-Quality-of-Life (OHRQoL) for edentulous patients. However the normal variance and mean of the baseline OHIP scores has not been reported. It would facilitate critical appraisal of studies if we had knowledge of the normal variation and mean of baseline OHIP-EDENT scores. An established figure for baseline OHIP-EDENT, obtained from a meta-analysis, would simplify comparisons of studies and quantify variations in initial OHRQoL of the trial participants...
February 20, 2018: Community Dental Health
https://www.readbyqxmd.com/read/29469998/the-effect-of-complete-denture-occlusion-on-function-and-patient-quality-of-life-systematic-review
#17
J Patel, C Granger, L Morrow
Edentulism presents an ongoing challenge for prosthodontic dentistry. Many aspects of complete denture construction lack contemporary evidence. One such aspect is denture occlusion. Balanced occlusion (BO) has become the prevailing occlusal scheme. It has been suggested that canine guidance (CG) is unsuitable for complete denture occlusion due to an increased risk for tipping of the prostheses. However it may be indicated in patients with minimal alveolus resorption. There has been limited evidence suggesting the superiority of either occlusal scheme over another...
February 20, 2018: Community Dental Health
https://www.readbyqxmd.com/read/29469968/first-follow-up-of-a-breakable-stent-for-implantation-in-infants-dedicated-for-a-life-long-stay
#18
Peter A Zartner, Ulrich Neudorf, Benjamin Bierbach, Chris Hart, Martin B Schneider
OBJECTIVE AND METHODS: The use of conventional metal stents in infants is severely limited by subsequent somatic growth. The use of a breakable balloon expandable stent (BS) designed for initial implant at small diameters but with properties that allow unlimited dilation in line with growth has potential advantages in this patient group. This study reports our experience with this stent between 2010 and 2014. A total of 17 BS were implanted in 14 infants (mean age 4.8 months). All but one stent was placed into the aorta to treat coarctation...
February 22, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29469647/how-skilled-do-israeli-nurses-perceive-themselves-to-be-in-providing-palliative-care-results-of-a-national-survey
#19
Shelli L Feder, David Collett, Samantha Conley, Dena Schulman-Green, Tikva Meron, Nathan Cherny
BACKGROUND: In Israel, palliative care (PC) services are limited. This study assessed Israeli nurses' perceived competencies and educational needs in providing PC. DESIGN: Online administration of the End-of-Life Professional Caregiver Survey (EPCS). SETTING/SUBJECTS: Oncology and PC nurses were identified through the Israel Ministry of Health and Oncology Nurses' Society. MEASUREMENTS: Demographic and practice data were analysed using analysis of variance tests to determine differences between nurse characteristics by EPCS domains...
February 2, 2018: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/29468915/association-between-sarcopenia-and-erectile-dysfunction-in-males-with-type-ii-diabetes-mellitus
#20
Sema Uçak, Rıdvan Sivritepe, Oğuzhan Kara, Ecem Sevim, Damla Ortaboz, Eyüp Veli Küçük, Sabri Atay, Arzu Çalışgan Baygül
BACKGROUND: The prevalence rates for both sarcopenia and erectile dysfunction (ED) gradually increase in middle-aged and elderly diabetic male population and they impair physical functioning, sexual functioning, and quality of life. The aim of the present study was to evaluate the sarcopenia in patients with diabetic ED. METHODS: The study included 98 male patients with type II diabetes mellitus (DM) aged 18-80 years. Blood chemistry and hormone levels were obtained...
February 22, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
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