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Saqib Hakak, Amirrudin Kamsin, Shivakumara Palaiahnakote, Omar Tayan, Mohd Yamani Idna Idris, Khir Zuhaili Abukhir
Arabic script is highly sensitive to changes in meaning with respect to the accurate arrangement of diacritics and other related symbols. The most sensitive Arabic text available online is the Digital Qur'an, the sacred book of Revelation in Islam that all Muslims including non-Arabs recite as part of their worship. Due to the different characteristics of the Arabic letters like diacritics (punctuation symbols), kashida (extended letters) and other symbols, it is written and available in different styles like Kufi, Naskh, Thuluth, Uthmani, etc...
2018: PloS One
R V Akhmetzianov, R A Bredikhin
Presented herein are the results of using Detralex in conservative treatment of women suffering from pelvic varicose veins. Our open prospective study included a total of 30 women with various forms of the course of the disease. All patients took Detralex prescribed at a daily dose of 1,000 mg for 60 days. Dynamic assessment of clinical manifestations of pelvic varicose veins in this cohort of patients was carried out with the help of a specialized quality-of-life questionnaire, an adapted clinical scale of determining disease severity, as well as a visual analogue scale for assessment of the main symptoms of the disease manifestations...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
P Tamiolakis, V-I Theofilou, K-I Tosios, A Sklavounou-Andrikopoulou
BACKGROUND: Oral verruciform xanthoma (OVX) is a rare lesion. The purpose of the present study is to describe the clinical features of 13 OVXs and review all cases reported in the English literature. MATERIAL AND METHODS: Thirteen cases of OVX diagnosed during a 47-year period were retrospectively collected. The patients' gender and age, as well as the main clinical features of the lesions were retrieved from the biopsy request forms. Pubmed®, Scopus® and Google ScholarTM electronic databases were searched with the key word "verruciform xanthoma"...
June 20, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
Giorgia De Berardis, Marco Scardapane, Giuseppe Lucisano, Santina Abbruzzese, Antonio Carlo Bossi, Elisa Cipponeri, Paola D'Angelo, Lucia Fontana, Roberta Lancione, Giuseppe Marelli, Luigi Sciangula, Antonio Nicolucci
OBJECTIVE: Insulin injection aspects, such as fear of injection and pain, directly affect glycemic control, patient adherence, and quality of life. Use of thinner and shorter needles could increase acceptance of injections. Aim of the study is to evaluate the non-inferiority of the new 34Gx3.5 mm needle compared to a 32GX4mm in patients with diabetes treated with insulin. METHODS: This is an open, randomized, two-period cross-over, noninferiority trial. Every treatment period lasted 3 weeks...
June 20, 2018: Current Medical Research and Opinion
Ivonne Ramirez-Silva, Juan A Rivera, Belem Trejo-Valdivia, Aryeh D Stein, Reynaldo Martorell, Isabelle Romieu, Albino Barraza-Villarreal, Laura Avila-Jiménez, Usha Ramakrishnan
Background: Rapid early weight gain has been associated with increased risk of obesity and cardiometabolic alterations, but evidence in low and middle-income countries is inconclusive. Objective: We evaluated the relation between relative weight gain from 1 to 48 mo with adiposity and cardiometabolic risk factors at 4-5 y of age, and determined if adiposity is a mediator for cardiometabolic alterations. Methods: We studied 428 Mexican children with anthropometric and blood pressure (BP) information from birth to 5 y of age from POSGRAD (Prenatal Omega-3 fatty acid Supplementation and child GRowth And Development), of whom 334 provided measures of adiposity and cardiometabolic risk markers at 4 y...
June 19, 2018: Journal of Nutrition
Letícia Pargendler Peres, Fabiana Bazanella Oliveira, André Cartell, Nicolle Gollo Mazzotti, Tania Ferreira Cestari
BACKGROUND: Psoriasis is a chronic and prevalent disease, and the associated pruritus is a common, difficult-to-control symptom. The mediators involved in psoriatic pruritus have not been fully established. OBJECTIVE: To evaluate associations between the number of mast cells in psoriatic lesions and the intensity of pruritus. METHODS: 29 patients with plaque psoriasis were recruited. In all participants, Psoriasis Area and Severity Index and Body Surface Area were assessed...
June 2018: Anais Brasileiros de Dermatologia
Camila Fernandes Pollo, Luciane Donida Bartoli Miot, Silmara Meneguin, Hélio Amante Miot
BACKGROUND: Melasma has a major impact on quality of life. MELASQoL is the only validated specific psychometric instrument to evaluate melasma QoL. OBJECTIVE: To develop and validate a multidimensional questionnaire for evaluating quality of life related to facial melasma. METHODS: Cross-sectional study performed in 2 institutions (public and private) from Brazil. Two focus groups were carried out: 5 board-certified dermatologists and 10 melasma patients, indicating the dimensions and significant units of melasma QoL...
June 2018: Anais Brasileiros de Dermatologia
Majid Mahallei, Mohammad Ahangarzadeh Rezaee, Bahareh Mehramuz, Shayan Beheshtirooy, Babak Abdinia
Sepsis is the systemic response to infection manifested as hyperthermia or hypothermia, tachycardia, tachypnea, and shock. This condition represents a major life-threatening factor in all age groups, particularly in neonatal period. The present study aimed to examine the results of blood, cerebrospinal fluid (CSF), and urine culture tests in suspected neonatal sepsis cases in northwestern Iran.This descriptive-analytical study was conducted on suspected neonatal sepsis cases hospitalized in Tabriz Children's Hospital...
June 2018: Medicine (Baltimore)
Viral N Shah, Lori M Laffel, R Paul Wadwa, Satish K Garg
BACKGROUND: This study assessed the accuracy of a factory-calibrated 10-day real-time continuous glucose monitoring (CGM) system (G6), which includes an automated sensor applicator. METHODS: Seventy-six participants with insulin-treated diabetes were enrolled at four U.S. sites as part of a larger study of G6 system performance. In-clinic visits for frequent comparative blood glucose measurements using a reference instrument (YSI) were conducted on days 1, 4-5, 7, and/or 10 of system use...
June 2018: Diabetes Technology & Therapeutics
Nabarun Karmakar, Anjan Datta, Kaushik Nag, Kaushik Tripura
Background: Quality of life (QOL) among elderly is an important area of concern which reflects the health status and well-being of this vulnerable population. Objectives: The objective of this study is to find out different domains of QOL and its association with sociodemographic factors among geriatric population. Methods: A community-based cross-sectional study was done among 76 persons aged 60 years and above from August 2016 to October 2016 in rural areas of Madhupur, Sepahijala district, Tripura...
April 2018: Indian Journal of Public Health
Maria Alessi, Katalin Szanto, Alexandre Dombrovski
ABSTRACTObjectives:To understand pathways to suicide by investigating the association between personality and suicidal motivations in mid- and late-life attempts. DESIGN: In a two-study approach, we measured different components of suicidal motivations using an existing self-report investigating reasons for suicide and a semi-qualitative assessment of motivational states preceding attempts. SETTING: Inpatient and outpatient psychiatric services in Pittsburgh, PA...
June 20, 2018: International Psychogeriatrics
Emilie Brenaut, Jon Anders Halvorsen, Florence J Dalgard, Lars Lien, Flora Balieva, Francesca Sampogna, Dennis Linder, Andrea W M Evers, Gregor B E Jemec, Uwe Gieler, Jacek Szepietowski, Françoise Poot, Ilknur K Altunay, Andrew Y Finlay, Sam S Salek, Csanad Szabo, Andrey Lvov, Servando E Marron, Lucia Tomas-Aragones, Jörg Kupfer, Laurent Misery
BACKGROUND: Prurigo is defined by the presence of chronic pruritus and multiple localized or generalized pruriginous lesions. OBJECTIVE: The aim of this study was to assess the psychological burden of prurigo in patients of European countries. METHODS: In this multicentre European study, 3635 general dermatology outpatients and 1359 controls were included. Socio-demographic data and answers to questionnaires (regarding quality of life, general health, anxiety and depression and suicidal ideation) were collected...
June 19, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Jacqueline S Birks, Richard J Harvey
BACKGROUND: Alzheimer's disease is the most common cause of dementia in older people. One approach to symptomatic treatment of Alzheimer's disease is to enhance cholinergic neurotransmission in the brain by blocking the action of the enzyme responsible for the breakdown of the neurotransmitter acetylcholine. This can be done by a group of drugs known as cholinesterase inhibitors. Donepezil is a cholinesterase inhibitor.This review is an updated version of a review first published in 1998...
June 18, 2018: Cochrane Database of Systematic Reviews
G Bali, S Kárpáti, M Sárdy, V Brodszky, B Hidvégi, F Rencz
BACKGROUND: Morphea can lead to considerable cosmetic or functional impairment; nevertheless, health-related quality of life (HRQoL) is rarely documented in adult morphea patients. OBJECTIVE: To investigate the impact of morphea on HRQoL and to identify determinants of impaired HRQoL. METHODS: A cross-sectional study has been carried out among adult morphea patients. HRQoL was evaluated by the Dermatology Life Quality Index (DLQI). The modified Localised Scleroderma Skin Severity Index (mLoSSI) and the Localised Scleroderma Damage Index (LoSDI) were applied to evaluate disease activity and damage, respectively...
June 19, 2018: Quality of Life Research
Huan Song, Fang Fang, Gunnar Tomasson, Filip K Arnberg, David Mataix-Cols, Lorena Fernández de la Cruz, Catarina Almqvist, Katja Fall, Unnur A Valdimarsdóttir
Importance: Psychiatric reactions to life stressors are common in the general population and may result in immune dysfunction. Whether such reactions contribute to the risk of autoimmune disease remains unclear. Objective: To determine whether there is an association between stress-related disorders and subsequent autoimmune disease. Design, Setting, and Participants: Population- and sibling-matched retrospective cohort study conducted in Sweden from January 1, 1981, to December 31, 2013...
June 19, 2018: JAMA: the Journal of the American Medical Association
Speranta Iacob, Razvan Cerban, Corina Pietrareanu, Carmen Ester, Razvan Iacob, Cristian Gheorghe, Irinel Popescu, Liana Gheorghe
BACKGROUND: Nowadays, interferon-free therapy using new direct-acting antivirals (DAA) has dramatically increased the cure rate across different HCV-infected patient populations, including groups traditionally viewed as difficult-to-treat (patients with co-infections, cirrhosis and liver transplant - LT recipients) with marked improvement in safety and tolerability. AIM: To present our experience with DAA therapy in LT recipients, as well as to compare pre- and post-treatment liver stiffness (LS) and noninvasive fibrosis scores...
June 2018: Journal of Gastrointestinal and Liver Diseases: JGLD
Nasim Baradaran-Akbarzadeh, Mahin Tafazoli, Morteza Mojahedi, Seyed Reza Mazlom
INTRODUCTION: Sexual health is one of the key factors to sustain marital life and having a good sexual function. On the other hand, temperament affects sexual function. Training is also one of the basic foundations for promoting sexual health. Therefore, the researcher has designed and implemented a study (2017) aimed "determining the study of educational package on sexual function in cold temperament women of reproductive age." METHODS: This randomized clinical trial study was performed on 80 women in two groups (40 in each group)...
2018: Journal of Education and Health Promotion
Tadashi Yokoyama, Akihiko Ohta, Satoshi Motoya, Masakazu Takazoe, Toshitaka Yajima, Masataka Date, Masahiro Nii, Péter Nagy, Yasuo Suzuki, Toshifumi Hibi
Background: US and European guidelines recommend budesonide for the treatment of mild-to-moderate active ileocolic Crohn's disease (CD). However, budesonide has not been approved, and mesalazine is widely used as first-line treatment in Japan. The objective of this study was to evaluate the efficacy and safety of budesonide in patients with mild-to-moderate active CD in Japan. Methods: In this phase 3 noninferiority study (NCT01514240), 112 patients with a baseline Crohn's Disease Activity Index (CDAI) score of 180-400 were randomized to budesonide or mesalazine for 8 weeks...
March 2018: Inflammatory Intestinal Diseases
Adnan I Qureshi, Muhammad A Saleem, Nishath Naseem, Shawn S Wallery
Background: Patients with vertebral, subclavian, or innominate arterial stenosis can present with recurrent symptoms that can adversely affect the quality of life (QOL). We aimed at determining the short-term effects of endovascular treatment (ET) on QOL in these patients. Methods: European Quality of Life Five Dimension Scale (EQ-5D) utility index and visual analog scale (VAS) were ascertained before and within one month of ET in patients with vertebral, subclavian, or innominate arterial stenosis with recurrent episodes of vertigo, near syncope, and/or ataxia...
June 2018: Journal of Vascular and Interventional Neurology
Astrid Lebert-Charron, Géraldine Dorard, Emilie Boujut, Jaqueline Wendland
Background: Becoming a parent is one of the most significant experiences in a woman's life. Including substantial and long-lasting mental, social, and physical charge, the parenting experience may also be a potentially stressful and overwhelming task. Since the eighties, the notion of parental burnout syndrome has gained increasing attention, but its contextual and psychological factors need to be better identified. Aims: To investigate a large array of contextual and psychological factors associated with maternal burnout syndrome in a French community-based population in order to contribute to better operationalize the notion of parental burnout and to explore its determinants...
2018: Frontiers in Psychology
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