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https://www.readbyqxmd.com/read/29149744/bacterial-community-structure-along-the-subtidal-sandy-sediment-belt-of-a-high-arctic-fjord-kongsfjorden-svalbard-islands
#1
Conte Antonella, Papale Maria, Amalfitano Stefano, Mikkonen Anu, Rizzo Carmen, De Domenico Emilio, Michaud Luigi, Lo Giudice Angelina
Open fjords are subject to contrasting environmental conditions, owing to meltwater glacial inputs, terrestrial runoff, and marine water mass exchanges, which are exacerbated by anthropogenic and climate perturbations. Following a slope-dependent water circulation, the subtidal sandy sediment belt regulates the convergent transport of nutrients downward the fjord depths, and the effective entrapment of suspended particles and microorganisms. In this study, we aimed at testing how glacial and seawater inputs may influence the bacterial community structure of subtidal sand deposits in the Kongsfjorden...
November 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29147502/chemical-space-guided-discovery-of-antimicrobial-bridged-bicyclic-peptides-against-pseudomonas-aeruginosa-and-its-biofilms
#2
Ivan Di Bonaventura, Xian Jin, Ricardo Visini, Daniel Probst, Sacha Javor, Bee-Ha Gan, Gaëlle Michaud, Antonino Natalello, Silvia Maria Doglia, Thilo Köhler, Christian van Delden, Achim Stocker, Tamis Darbre, Jean-Louis Reymond
Herein we report the discovery of antimicrobial bridged bicyclic peptides (AMBPs) active against Pseudomonas aeruginosa, a highly problematic Gram negative bacterium in the hospital environment. Two of these AMBPs show strong biofilm inhibition and dispersal activity and enhance the activity of polymyxin, currently a last resort antibiotic against which resistance is emerging. To discover our AMBPs we used the concept of chemical space, which is well known in the area of small molecule drug discovery, to define a small number of test compounds for synthesis and experimental evaluation...
October 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29146853/genome-sequences-of-four-subcluster-l2-mycobacterium-phages-finemlucis-miley16-wilder-and-zakai
#3
Christopher D Herren, Alexandra Peister, Timothy S Breton, Maggie S Hill, Marcy S Anderson, Adeline W Chang, Sydney B Klein, Mackenzie M Thornton, Stacy J Vars, Kasey E Wagner, Paige L Wiebe, Thomas G Williams, Coraima P Yanez, Jasanta M Ackles, Darius Artis, Ryan J Brazier, Ronald J Bryant, Kerel O Callwood, Isaiah H Carter, Cameron L DeBose, Christian D Edwards, Isaiah C Ezemba, Renshal R Joaquin, Zakai M Meghoo-Peddie, Ziha G Meghoo-Peddie, Ryan W Moore, Christopher E Smith, Adam J Turner, Raymond L Vorters, Jeffrey J Wider, Liesel L Krout, Mia S Comis, Madison J Davick, Eli E Michaud, Bailey E Shevenell, Sarah E Stanley, Chelsey I Frank, Jacob R Montgomery, Lawrence S Blumer, Jean A Doty, Martha Smith-Caldas, Welkin H Pope, Steven G Cresawn, Daniel A Russell, Rebecca A Garlena, Deborah Jacobs-Sera, Graham F Hatfull
Four subcluster L2 mycobacteriophages, Finemlucis, Miley16, Wilder, and Zakai, that infect Mycobacterium smegmatis mc(2)155 were isolated. The four phages are closely related to each other and code for 12 to 14 tRNAs and 130 to 132 putative protein-coding genes, including tyrosine integrases, cro, immunity repressors, and excise genes involved in the establishment of lysogeny.
November 16, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29135619/the-heart-pathway-and-hospital-cost-savings
#4
Amy A Yau, Long T Nguyendo, LaKeesha L Lockett, Edward Michaud
Chest pain is a common complaint in emergency departments. Several guidelines and tools exist to help the clinician determine need for hospitalization. For low-risk patients, clinical judgment can underestimate a patient's risk of major adverse cardiac event. Implementation of an advanced diagnostic protocol with the HEART Pathway can reduce hospital cost. For our academic institution, we saw an approximate $1 million in total savings during the initial implementation year along with increased outpatient visits...
December 2017: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/29131780/ceftriaxone-resistant-neisseria-gonorrhoeae-canada-2017
#5
Brigitte Lefebvre, Irene Martin, Walter Demczuk, Lucie Deshaies, Stéphanie Michaud, Annie-Claude Labbé, Marie-Claude Beaudoin, Jean Longtin
We identified a ceftriaxone-resistant Neisseria gonorrhoeae isolate in a patient in Canada. This isolate carried the penA-60 allele, which differs substantially from its closest relative, mosaic penA XXVII (80% nucleotide identity). Epidemiologic and genomic data suggest spread from Asia. Antimicrobial susceptibility surveillance helps prevent spread of highly resistant N. gonorrhoeae strains.
February 15, 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29123966/pd-1-blockade-at-the-time-of-tumor-escape-potentiates-the-immune-mediated-antitumor-effects-of-a-melanoma-targeting-monoclonal-antibody
#6
Laetitia They, Henri-Alexandre Michaud, Ondine Becquart, Virginie Lafont, Bernard Guillot, Florence Boissière-Michot, Marta Jarlier, Caroline Mollevi, Jean-François Eliaou, Nathalie Bonnefoy, Laurent Gros
Tumor antigen-targeting monoclonal antibodies (TA-targeting mAbs) are used as therapeutics in many malignancies and their capacity to mobilize the host immunity puts them at the forefront of anti-cancer immunotherapies. Both innate and adaptive immune cells have been associated with the therapeutic activity of such antibodies, but tumor escape from mAb-induced tumor immune surveillance remains one of the main clinical issues. In this preclinical study, we grafted immunocompetent and immunocompromised mice with the B16F10 mouse melanoma cell line and treated them with the TA99 TA-targeting mAb to analyze the immune mechanisms associated with the tumor response and resistance to TA99 monotherapy...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29118110/cellular-functions-of-the-autism-risk-factor-ptchd1-in-mice
#7
David Tora, Andrea M Gomez, Jean-Francois Michaud, Patricia T Yam, Frédéric Charron, Peter Scheiffele
The gene PTCHD1 is mutated in patients with autism spectrum disorders (ASD) and intellectual disabilities (ID) and has been hypothesized to contribute to Sonic hedgehog (Shh) signaling and synapse formation. We identify a panel of Ptchd1 interacting proteins that include postsynaptic density proteins and the retromer complex, revealing a link to critical regulators of dendritic and postsynaptic trafficking. Ptchd1 knock-out male mice exhibit cognitive alterations, including defects in a novel object recognition task...
November 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29113407/healing-touch-in-radiation-therapy-is-the-benefit-tangible
#8
Jean-Baptiste Guy, Sacha Bard-Reboul, Jane-Chloé Trone, Alexis Vallard, Sophie Espenel, Julien Langrand-Escure, Anis Hamrouni, Majed Ben Mrad, Stéphanie Morisson, Patrick Michaud, Nicolas Magné, Chloé Rancoule
Background: Cancer patients tend to use more and more complementary or alternative medicine concomitantly to radiotherapy. A large part of these patients have recourse to Mind and Body practice, mainly with biofield healers or magnetizers, without any level of evidence. The aim of the present study was to report epidemiologic data on biofield healers in radiation therapy patients, and to assess the possible objective and subjective benefits. Materials and Methods: A retrospective study was conducted in a French cancer institute...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29100083/high-rate-of-recurrent-de-novo-mutations-in-developmental-and-epileptic-encephalopathies
#9
Fadi F Hamdan, Candace T Myers, Patrick Cossette, Philippe Lemay, Dan Spiegelman, Alexandre Dionne Laporte, Christina Nassif, Ousmane Diallo, Jean Monlong, Maxime Cadieux-Dion, Sylvia Dobrzeniecka, Caroline Meloche, Kyle Retterer, Megan T Cho, Jill A Rosenfeld, Weimin Bi, Christine Massicotte, Marguerite Miguet, Ledia Brunga, Brigid M Regan, Kelly Mo, Cory Tam, Amy Schneider, Georgie Hollingsworth, David R FitzPatrick, Alan Donaldson, Natalie Canham, Edward Blair, Bronwyn Kerr, Andrew E Fry, Rhys H Thomas, Joss Shelagh, Jane A Hurst, Helen Brittain, Moira Blyth, Robert Roger Lebel, Erica H Gerkes, Laura Davis-Keppen, Quinn Stein, Wendy K Chung, Sara J Dorison, Paul J Benke, Emily Fassi, Nicole Corsten-Janssen, Erik-Jan Kamsteeg, Frederic T Mau-Them, Ange-Line Bruel, Alain Verloes, Katrin Õunap, Monica H Wojcik, Dara V F Albert, Sunita Venkateswaran, Tyson Ware, Dean Jones, Yu-Chi Liu, Shekeeb S Mohammad, Peyman Bizargity, Carlos A Bacino, Vincenzo Leuzzi, Simone Martinelli, Bruno Dallapiccola, Marco Tartaglia, Lubov Blumkin, Klaas J Wierenga, Gabriela Purcarin, James J O'Byrne, Sylvia Stockler, Anna Lehman, Boris Keren, Marie-Christine Nougues, Cyril Mignot, Stéphane Auvin, Caroline Nava, Susan M Hiatt, Martina Bebin, Yunru Shao, Fernando Scaglia, Seema R Lalani, Richard E Frye, Imad T Jarjour, Stéphanie Jacques, Renee-Myriam Boucher, Emilie Riou, Myriam Srour, Lionel Carmant, Anne Lortie, Philippe Major, Paola Diadori, François Dubeau, Guy D'Anjou, Guillaume Bourque, Samuel F Berkovic, Lynette G Sadleir, Philippe M Campeau, Zoha Kibar, Ronald G Lafrenière, Simon L Girard, Saadet Mercimek-Mahmutoglu, Cyrus Boelman, Guy A Rouleau, Ingrid E Scheffer, Heather C Mefford, Danielle M Andrade, Elsa Rossignol, Berge A Minassian, Jacques L Michaud
Developmental and epileptic encephalopathy (DEE) is a group of conditions characterized by the co-occurrence of epilepsy and intellectual disability (ID), typically with developmental plateauing or regression associated with frequent epileptiform activity. The cause of DEE remains unknown in the majority of cases. We performed whole-genome sequencing (WGS) in 197 individuals with unexplained DEE and pharmaco-resistant seizures and in their unaffected parents. We focused our attention on de novo mutations (DNMs) and identified candidate genes containing such variants...
November 2, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29094867/electronic-cigarette-exposure-calls-to-wisconsin-poison-control-centers-2010%C3%A2-2015
#10
Debora Weiss, Carrie D Tomasallo, Jon G Meiman, Paul D Creswell, Paul C Melstrom, David D Gummin, Disa J Patel, Nancy T Michaud, Heather A Sebero, Henry A Anderson
BACKGROUND: E-cigarettes are battery-powered devices that deliver nicotine and flavorings by aerosol and have been marketed in the United States since 2007. Because e-cigarettes have increased in popularity, toxicity potential from device misuse and malfunction also has increased. National data indicate that during 2010–2014, exposure calls to US poison control centers increased only 0.3% for conventional cigarette exposures, whereas calls increased 41.7% for e-cigarette exposures. METHODS: We characterized cigarette and e-cigarette exposure calls to the Wisconsin Poison Center January 1, 2010 through October 10, 2015...
December 2016: WMJ: Official Publication of the State Medical Society of Wisconsin
https://www.readbyqxmd.com/read/29081988/infection-rates-in-patients-from-five-rheumatoid-arthritis-ra-registries-contextualising-an-ra-clinical-trial-programme
#11
Hisashi Yamanaka, Johan Askling, Niklas Berglind, Stefan Franzen, Thomas Frisell, Christopher Garwood, Jeffrey D Greenberg, Meilien Ho, Marie Holmqvist, Laura Novelli Horne, Eisuke Inoue, Kaleb Michaud, Dimitrios A Pappas, George Reed, Deborah Symmons, Eiichi Tanaka, Trung N Tran, Suzanne M M Verstappen, Eveline Wesby-van Swaay, Fredrik Nyberg
OBJECTIVE: Patients with rheumatoid arthritis (RA) have an increased risk of serious infections. Comparing infection rates across RA populations is complicated by differences in background infection risk, population composition and study methodology. We measured infection rates from five RA registries globally, with the aim to contextualise infection rates from an RA clinical trials population. METHODS: We used data from Consortium of Rheumatology Research of North America (CORRONA) (USA), Swedish Rheumatology Quality of Care Register (Sweden), Norfolk Arthritis Register (UK), CORRONA International (multiple countries) and Institute of Rheumatology Rheumatoid Arthritis (Japan) and an RA clinical trial programme (fostamatinib)...
2017: RMD Open
https://www.readbyqxmd.com/read/29078177/modelling-tetraselmis-sp-growth-kinetics-and-optimizing-bioactive-compound-production-through-environmental-conditions
#12
Mouna Dammak, Bilel Hadrich, Mohamed Barkallah, Faiez Hentati, Hajer Ben Hlima, Chantal Pichon, Michel Denis, Imen Fendri, Philippe Michaud, Slim Abdelkafi
The aim of this study is to predict Tetraselmis cells growth-kinetic and to induce the synthesis of bioactive compounds (chlorophylls, carotenoids and starch) with high potential for biotechnological applications. Using the statistical criteria, the Baranyi-Roberts model has been selected to estimate the microalgae growth-kinetic values. The simultaneous effects of salinity, light intensity and pH of culture medium were investigated to maximize the production of total chlorophylls, carotenoids and starch. The optimal culture conditions for the production of these compounds were found using Box-Behnken Design...
October 10, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29068263/hydric-costs-of-reproduction-pregnancy-increases-evaporative-water-loss-in-the-snake-vipera-aspis
#13
Olivier Lourdais, Andréaz Dupoué, Michaël Guillon, Gaëtan Guiller, Bruno Michaud, Dale F DeNardo
Water constraints can mediate evolutionary conflict either among individuals (e.g., parent-offspring conflict, sexual conflict) or within an individual (e.g., cost of reproduction). During pregnancy, water is of particular importance because the female provides all water needed for embryonic development and experiences important maternal shifts in behavior and physiology that, together, can compromise female water balance if water availability is limited. We examined the effect of pregnancy on evaporative water loss and microhabitat selection in a viviparous snake, the aspic viper...
November 2017: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/29058426/reversible-redox-switching-of-chromophoric-phenylmethylenepyrans-by-carbon-carbon-bond-making-breaking
#14
Laurianne Wojcik, François Michaud, Sébastien Gauthier, Nolwenn Cabon, Pascal Le Poul, Frederic Gloaguen, Nicolas Le Poul
Electrochromic organic systems that can undergo substantial variation of their optical properties upon electron stimulus are of high interest for the development of functional materials. In particular, devices based on radical dimerization are appropriate because of the effectiveness and speed of carbon-carbon bond making/breaking. Phenylmethylenepyrans are organic chromophores which are well suited for such purposes since their oxidation leads to the reversible formation of bispyrylium species by radical dimerization...
October 31, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29049957/non-target-impacts-of-soybean-insecticidal-seed-treatments-on-the-life-history-and-behavior-of-podisus-nigrispinus-a-predator-of-fall-armyworm
#15
Pablo C Gontijo, Dyrson O Abbade Neto, Rodrigo L Oliveira, J P Michaud, Geraldo A Carvalho
The treatment of seeds with systemic insecticides has become a common practice worldwide. However, this prophylactic use of insecticides has been questioned recently because of the potential risks to non-target organisms. This study assessed the non-target effects of chlorantraniliprole and thiamethoxam seed treatments on the life history and walking behavior of Podisus nigrispinus (Dallas), as well as the efficacy of these insecticides for controlling Spodoptera frugiperda (Smith). Thiamethoxam caused mortality of P...
October 10, 2017: Chemosphere
https://www.readbyqxmd.com/read/29037190/do-mobile-clinics-provide-high-quality-antenatal-care-a-comparison-of-care-delivery-knowledge-outcomes-and-perception-of-quality-of-care-between-fixed-and-mobile-clinics-in-central-haiti
#16
Erica Phillips, Rebecca J Stoltzfus, Lesly Michaud, Gracia Lionel Fils Pierre, Francoise Vermeylen, David Pelletier
BACKGROUND: Antenatal care (ANC) is an important health service for women in developing countries, with numerous proven benefits. Global coverage of ANC has steadily increased over the past 30 years, in part due to increased community-based outreach. However, commensurate improvements in health outcomes such as reductions in the prevalence of maternal anemia and infants born small-for-gestational age have not been achieved, even with increased coverage, indicating that quality of care may be inadequate...
October 16, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29029382/differential-impacts-of-six-insecticides-on-a-mealybug-and-its-coccinellid-predator
#17
Paulo R R Barbosa, Martin D Oliveira, Eduardo M Barros, J P Michaud, Jorge B Torres
Broad-spectrum insecticides may disrupt biological control and cause pest resurgence due to their negative impacts on natural enemies. The preservation of sustainable pest control in agroecosystems requires parallel assessments of insecticide toxicity to target pests and their key natural enemies. In the present study, the leaf dipping method was used to evaluate the relative toxicity of six insecticides to the striped mealybug, Ferrisia dasylirii (Cockerell) (Hemiptera: Pseudococcidae) and its predator, Tenuisvalvae notata (Mulsant) (Coleoptera: Coccinellidae)...
January 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29021841/2017-hrs-ehra-ecas-aphrs-solaece-expert-consensus-statement-on-catheter-and-surgical-ablation-of-atrial-fibrillation-executive-summary
#18
Hugh Calkins, Gerhard Hindricks, Riccardo Cappato, Young-Hoon Kim, Eduardo B Saad, Luis Aguinaga, Joseph G Akar, Vinay Badhwar, Josep Brugada, John Camm, Peng-Sheng Chen, Shih-Ann Chen, Mina K Chung, Jens Cosedis Nielsen, Anne B Curtis, D Wyn Davies, John D Day, André d'Avila, N M S Natasja de Groot, Luigi Di Biase, Mattias Duytschaever, James R Edgerton, Kenneth A Ellenbogen, Patrick T Ellinor, Sabine Ernst, Guilherme Fenelon, Edward P Gerstenfeld, David E Haines, Michel Haissaguerre, Robert H Helm, Elaine Hylek, Warren M Jackman, Jose Jalife, Jonathan M Kalman, Josef Kautzner, Hans Kottkamp, Karl Heinz Kuck, Koichiro Kumagai, Richard Lee, Thorsten Lewalter, Bruce D Lindsay, Laurent Macle, Moussa Mansour, Francis E Marchlinski, Gregory F Michaud, Hiroshi Nakagawa, Andrea Natale, Stanley Nattel, Ken Okumura, Douglas Packer, Evgeny Pokushalov, Matthew R Reynolds, Prashanthan Sanders, Mauricio Scanavacca, Richard Schilling, Claudio Tondo, Hsuan-Ming Tsao, Atul Verma, David J Wilber, Teiichi Yamane
No abstract text is available yet for this article.
October 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29021764/multicomponent-intervention-for-patients-admitted-to-an-emergency-unit-for-suicide-attempt-an-exploratory-study
#19
Sebastien Brovelli, Yves Dorogi, Adam-Scott Feiner, Philippe Golay, Friedrich Stiefel, Charles Bonsack, Laurent Michaud
Suicide is a major cause of premature deaths worldwide and belongs to the top priority public health issues. While suicide attempt is the most important risk factor for completed suicide, intervention for suicide attempters (SA) have produced mixed results. Since an important proportion of SA request medical care, emergency units (EU) are an opportune setting to implement such interventions. This exploratory study evaluated the feasibility and acceptability of a multicomponent intervention for SA admitted to an EU...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29016841/2017%C3%A2-hrs-ehra-ecas-aphrs-solaece-expert-consensus-statement-on-catheter-and-surgical-ablation-of-atrial-fibrillation-executive-summary
#20
Hugh Calkins, Gerhard Hindricks, Riccardo Cappato, Young-Hoon Kim, Eduardo B Saad, Luis Aguinaga, Joseph G Akar, Vinay Badhwar, Josep Brugada, John Camm, Peng-Sheng Chen, Shih-Ann Chen, Mina K Chung, Jens Cosedis Nielsen, Anne B Curtis, D Wyn Davies, John D Day, André d'Avila, N M S Natasja de Groot, Luigi Di Biase, Mattias Duytschaever, James R Edgerton, Kenneth A Ellenbogen, Patrick T Ellinor, Sabine Ernst, Guilherme Fenelon, Edward P Gerstenfeld, David E Haines, Michel Haissaguerre, Robert H Helm, Elaine Hylek, Warren M Jackman, Jose Jalife, Jonathan M Kalman, Josef Kautzner, Hans Kottkamp, Karl Heinz Kuck, Koichiro Kumagai, Richard Lee, Thorsten Lewalter, Bruce D Lindsay, Laurent Macle, Moussa Mansour, Francis E Marchlinski, Gregory F Michaud, Hiroshi Nakagawa, Andrea Natale, Stanley Nattel, Ken Okumura, Douglas Packer, Evgeny Pokushalov, Matthew R Reynolds, Prashanthan Sanders, Mauricio Scanavacca, Richard Schilling, Claudio Tondo, Hsuan-Ming Tsao, Atul Verma, David J Wilber, Teiichi Yamane
No abstract text is available yet for this article.
September 15, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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