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https://www.readbyqxmd.com/read/27898516/clinical-evaluation-of-large-diameter-rigid-gas-permeable-versus-soft-toric-contact-lenses-for-the-correction-of-refractive-astigmatism-a-multicenter-study
#1
Langis Michaud, Edward S Bennett, Stephanie L Woo, Renee Reeder, Bruce W Morgan, Amy Dinardo, Jennifer S Harthan
PURPOSE: This study aims to address the clinical performance of a large diameter rigid gas permeable lens (LRGP) in a group of subjects with low-to-moderate (0.75-2.75 D) refractive astigmatism. An additional goal was to determine whether soft toric or LRGP contact lenses performed better objectively in the correction of astigmatism and to determine which modality is preferred by subjects. METHODS: This was a multisite prospective cross-over clinical study. Ten asymptomatic contact lens wearers per site (four university clinics) were recruited and randomly assigned to group A or group B...
November 24, 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/27898215/randomized-trial-of-pleural-fluid-drainage-frequency-in-patients-with-malignant-pleural-effusions-the-asap-trial
#2
Momen M Wahidi, Chakravarthy Reddy, Lonny Yarmus, David Feller-Kopman, Ali Musani, R Wesley Shepherd, Hans Lee, Rabih Bechara, Carla Lamb, Scott Shofer, Kamran Mahmood, Gaetane Michaud, Jonathan Puchalski, Samaan Rafeq, Stephen M Cattaneo, John Mullon, Steven Leh, Martin Mayse, Samantha M Thomas, Bercedis Peterson, Richard W Light
RATIONALE: Patients with malignant pleural effusions have significant dyspnea and shortened life expectancy. Indwelling pleural catheters (IPC) allow patients to drain pleural fluid at home and can lead to auto-pleurodesis. The optimal drainage frequency to achieve auto-pleurodesis and freedom from catheter has not been determined. OBJECTIVE: To determine whether an aggressive daily drainage strategy is superior to the current standard every other day drainage of pleural fluid in achieving auto-pleurodesis...
November 29, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27893815/an-accessory-protease-inhibitor-to-increase-the-yield-and-quality-of-a-tumour-targeting-mab-in-nicotiana-benthamiana-leaves
#3
Philippe V Jutras, Carla Marusic, Chiara Lonoce, Carole Deflers, Marie-Claire Goulet, Eugenio Benvenuto, Dominique Michaud, Marcello Donini
The overall quality of recombinant IgG antibodies in plants is dramatically compromised by host endogenous proteases. Different approaches have been developed to reduce the impact of endogenous proteolysis on IgGs, notably involving site-directed mutagenesis to eliminate protease-susceptible sites or the in situ mitigation of host protease activities to minimize antibody processing in the cell secretory pathway. We here characterized the degradation profile of H10, a human tumour-targeting monoclonal IgG, in leaves of Nicotiana benthamiana also expressing the human serine protease inhibitor α1-antichymotrypsin or the cysteine protease inhibitor tomato cystatin SlCYS8...
2016: PloS One
https://www.readbyqxmd.com/read/27883275/comparative-analysis-of-three-human-adipocyte-size-measurement-methods-and-their-relevance-for-cardiometabolic-risk
#4
Sofia Laforest, Andréanne Michaud, Gaétan Paris, Mélissa Pelletier, Hubert Vidal, Alain Géloën, André Tchernof
OBJECTIVE: To determine whether adipocyte diameters from three measurement methods are similarly associated with adiposity measurements and cardiometabolic variables. METHODS: Surgical samples of omental and abdominal subcutaneous adipose tissue were obtained in a sample of 60 women (age 35-59 years; body mass index 20.3-41.1 kg/m(2) ). Median adipocyte diameter of the main cell population was determined by collagenase digestion, osmium tetroxide fixation, and histological analysis...
November 24, 2016: Obesity
https://www.readbyqxmd.com/read/27865870/african-and-classical-swine-fever-situation-in-ivory-coast-and-neighboring-countries-2008-2013
#5
K V Kouakou, V Michaud, H G Biego, H P G Gnabro, A V Kouakou, A M Mossoun, J A Awuni, G L Minoungou, G L Aplogan, F K Awoumé, E Albina, R Lancelot, E Couacy-Hymann
This study was conducted from 2008 to 2013 to determine the animal health status of Ivory Coast and neighboring countries (Burkina Faso, Ghana, Togo and Benin) for African swine fever (ASF) and classical swine fever (CSF), and to assess the risk factors for ASF introduction in Ivory Coast. Ivory Coast had probably been free from ASF from 1998 to 2014 when it was re-introduced in this country. However, the ASF virus was found in all neighboring countries. In contrast, no evidence of CSF infection was found so far in Ivory Coast and neighboring countries...
November 16, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27861844/periodontal-disease-and-risk-of-non-hodgkin-lymphoma-in-the-health-professionals-follow-up-study
#6
Kimberly A Bertrand, Janki Shingala, Andrew Evens, Brenda M Birmann, Edward Giovannucci, Dominique S Michaud
Periodontal disease is a chronic inflammatory condition that has been associated with chronic diseases, including cancer. In an earlier prospective cohort analysis within the Health Professionals Follow-Up Study (HPFS), we observed a 31% higher risk of non-Hodgkin lymphoma (NHL) among participants with severe periodontal disease at baseline. Here, we extend the study with an additional 8 years of follow-up, and conduct analyses with updated periodontal disease status and NHL subtypes. The HPFS is an ongoing prospective cohort study of 51,529 men in the U...
November 15, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27860063/a-comparison-of-women-and-men-undergoing-catheter-ablation-for-sustained-monomorphic-ventricular-tachycardia
#7
Samuel H Baldinger, Saurabh Kumar, Jorge Romero, Akira Fujii, Laurence M Epstein, Gregory F Michaud, Roy John, Usha B Tedrow, William G Stevenson
INTRODUCTION: Women are underrepresented in clinical studies on catheter ablation (CA) for ventricular tachycardia (VT). The role of gender as a predictor for VT recurrence after CA is unclear and complication rates have not been compared in a large cohort. METHODS AND RESULTS: We analyzed data of consecutive patients undergoing CA for sustained monomorphic VT at our center between 2005 and 2015. A total of 948 patients underwent 1314 ablation procedures: 114 patients without SHD (48% female), 486 with coronary artery disease (CAD) (9% female), 301 with non-ischemic cardiomyopathy (NICM) (22% female), and 46 with arrhythmogenic right ventricular cardiomyopathy (ARVC) (17% female)...
November 18, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27855955/enrichment-isolation-and-biodegradation-potential-of-psychrotolerant-polychlorinated-biphenyl-degrading-bacteria-from-the-kongsfjorden-svalbard-islands-high-arctic-norway
#8
Maria Papale, Stefania Giannarelli, Sandro Francesconi, Gaetano Di Marco, Anu Mikkonen, Antonella Conte, Carmen Rizzo, Emilio De Domenico, Luigi Michaud, Angelina Lo Giudice
Persistent organic pollutants (POPs), such as polychlorinated biphenyls (PCBs), have been detected in abiotic Arctic matrices: surface sediments and seawater from coastal areas in the Kongsfjorden were collected and analyzed. Levels of PCBs varied depending on the sampling site. Total PCB concentrations were between 11.63 (site C2W) and 27.69pgl(-1) (site AW). These levels were comparable to those reported previously in lake sediments from the northern Svalbard. The occurrence and biodegradation potential of cold-adapted PCB-oxidizing bacteria in seawater and sediment along the fjord was also evaluated...
November 14, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27850497/859-intravenous-chlorothiazide-versus-enteral-metolazone-for-sequential-nephron-blockade-in-the-icu
#9
Christopher Michaud, Kendall Mintus
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27836820/risk-of-diabetes-mellitus-associated-with-disease-modifying-antirheumatic-drugs-and-statins-in-rheumatoid-arthritis
#10
Gulsen Ozen, Sofia Pedro, Marie E Holmqvist, Michael Avery, Frederick Wolfe, Kaleb Michaud
OBJECTIVE: To investigate the rate of incident diabetes mellitus (DM) in patients with rheumatoid arthritis (RA) and the impact of disease-modifying antirheumatic drug (DMARD) and statin treatments. METHODS: We studied patients with RA and ≥1 year participation in the National Data Bank for Rheumatic Diseases without baseline DM from 2000 through 2014. DM was determined by self-report or initiating DM medication. DMARDs were categorised into four mutually exclusive groups: (1) methotrexate monotherapy (reference); (2) any abatacept with or without synthetic DMARDs (3) any other DMARDs with methotrexate; (4) all other DMARDs without methotrexate; along with separate statin, glucocorticoid and hydroxychloroquine (yes/no) variables...
November 11, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27833599/physiological-ecology-of-microorganisms-in-subglacial-lake-whillans
#11
Trista J Vick-Majors, Andrew C Mitchell, Amanda M Achberger, Brent C Christner, John E Dore, Alexander B Michaud, Jill A Mikucki, Alicia M Purcell, Mark L Skidmore, John C Priscu
Subglacial microbial habitats are widespread in glaciated regions of our planet. Some of these environments have been isolated from the atmosphere and from sunlight for many thousands of years. Consequently, ecosystem processes must rely on energy gained from the oxidation of inorganic substrates or detrital organic matter. Subglacial Lake Whillans (SLW) is one of more than 400 subglacial lakes known to exist under the Antarctic ice sheet; however, little is known about microbial physiology and energetics in these systems...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27830185/fhf1-fgf12-epileptic-encephalopathy
#12
Sameer Al-Mehmadi, Miranda Splitt, Venkateswaran Ramesh, Suzanne DeBrosse, Kimberly Dessoffy, Fan Xia, Yaping Yang, Jill A Rosenfeld, Patrick Cossette, Jacques L Michaud, Fadi F Hamdan, Philippe M Campeau, Berge A Minassian
Voltage-gated sodium channels (Navs) are mainstays of neuronal function, and mutations in the genes encoding CNS Navs (Nav1.1 [SCN1A], Nav1.2 [SCN2A], Nav1.3 [SCN3A], and Nav1.6 [SCN8A]) are causes of some of the most common and severe genetic epilepsies and epileptic encephalopathies (EE).(1) Fibroblast-growth-factor homologous factors (FHFs) compose a family of 4 proteins that interact with the C-terminal tails of Navs to modulate the channels' fast, and long-term, inactivations.(2)FHF2 mutation is a rare cause of generalized epilepsy with febrile seizures plus (GEFS+)...
December 2016: Neurology. Genetics
https://www.readbyqxmd.com/read/27827368/decrease-of-syngap1-in-gabaergic-cells-impairs-inhibitory-synapse-connectivity-synaptic-inhibition-and-cognitive-function
#13
Martin H Berryer, Bidisha Chattopadhyaya, Paul Xing, Ilse Riebe, Ciprian Bosoi, Nathalie Sanon, Judith Antoine-Bertrand, Maxime Lévesque, Massimo Avoli, Fadi F Hamdan, Lionel Carmant, Nathalie Lamarche-Vane, Jean-Claude Lacaille, Jacques L Michaud, Graziella Di Cristo
Haploinsufficiency of the SYNGAP1 gene, which codes for a Ras GTPase-activating protein, impairs cognition both in humans and in mice. Decrease of Syngap1 in mice has been previously shown to cause cognitive deficits at least in part by inducing alterations in glutamatergic neurotransmission and premature maturation of excitatory connections. Whether Syngap1 plays a role in the development of cortical GABAergic connectivity and function remains unclear. Here, we show that Syngap1 haploinsufficiency significantly reduces the formation of perisomatic innervations by parvalbumin-positive basket cells, a major population of GABAergic neurons, in a cell-autonomous manner...
November 9, 2016: Nature Communications
https://www.readbyqxmd.com/read/27820756/effect-of-workplace-weight-management-on-health-care-expenditures-and-quality-of-life
#14
Tzeyu L Michaud, John A Nyman, Eric Jutkowitz, Dejun Su, Bryan Dowd, Jean M Abraham
OBJECTIVE: We examined the effectiveness of the weight management program used by the University of Minnesota in reducing health care expenditures and improving quality of life of its employees, and also in reducing their absenteeism during a 3-year intervention. METHODS: A differences-in-differences regression approach was used to estimate the effect of weight management participation. We further applied ordinary least squares regression models with fixed effects to estimate the effect in an alternative analysis...
November 2016: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27794354/erratum-personal-and-situational-variables-associated-with-wind-turbine-noise-annoyance-j-acoust-soc-am-139-3-1455-1466-2016
#15
David S Michaud, Stephen E Keith, Katya Feder, Sonia A Voicescu, Leonora Marro, John Than, Mireille Guay, Tara Bower, Allison Denning, Eric Lavigne, Chantal Whelan, Sabine A Janssen, Tony Leroux, Frits van den Berg
No abstract text is available yet for this article.
October 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27794326/erratum-exposure-to-wind-turbine-noise-perceptual-responses-and-reported-health-effects-j-acoust-soc-am-139-3-1443-1454-2016
#16
David S Michaud, Katya Feder, Stephen E Keith, Sonia A Voicescu, Leonora Marro, John Than, Mireille Guay, Allison Denning, D'Arcy McGuire, Tara Bower, Eric Lavigne, Brian J Murray, Shelly K Weiss, Frits van den Berg
No abstract text is available yet for this article.
October 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27788409/evaluation-of-human-epidermal-growth-factor-receptor-2-her2-single-nucleotide-polymorphisms-snps-in-normal-and-breast-tumor-tissues-and-their-link-with-breast-cancer-prognostic-factors
#17
Daniela Furrer, Julie Lemieux, Marc-André Côté, Louise Provencher, Christian Laflamme, Frédéric Barabé, Simon Jacob, Annick Michaud, Caroline Diorio
Amplification of the human epidermal growth factor receptor 2 (HER2) gene is associated with worse prognosis and decreased overall survival in breast cancer patients. The HER2 gene contains several polymorphisms; two of the best-characterized HER2 polymorphisms are Ile655Val and Ala1170Pro. The aim of this study was to evaluate the association between these two HER2 polymorphisms in normal breast and breast cancer tissues and known breast cancer prognostic factors in a retrospective cohort study of 73 women with non-metastatic HER2-positive breast cancer...
December 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27782264/metal-homeostasis-disruption-and-mitochondrial-dysfunction-in-hepatocytes-exposed-to-sub-toxic-doses-of-zinc-oxide-nanoparticles
#18
M Chevallet, B Gallet, A Fuchs, P H Jouneau, K Um, E Mintz, I Michaud-Soret
Increased production and use of zinc oxide nanoparticles (ZnO-NPs) in consumer products has prompted the scientific community to investigate their potential toxicity, and understand their impact on the environment and organisms. Molecular mechanisms involved in ZnO-NP toxicity are still under debate and focus essentially on high dose expositions. In our study, we chose to evaluate the effect of sub-toxic doses of ZnO-NPs on human hepatocytes (HepG2) with a focus on metal homeostasis and redox balance disruptions...
October 26, 2016: Nanoscale
https://www.readbyqxmd.com/read/27781325/beyond-the-storm-comparison-of-clinical-factors-arrhythmogenic-substrate-and-catheter-ablation-outcomes-in-structural-heart-disease-patients-with-versus-those-without-a-history-of-ventricular-tachycardia-storm
#19
Saurabh Kumar, Akira Fujii, Sunil Kapur, Jorge Romero, Nishaki K Mehta, Shinichi Tanigawa, Laurence M Epstein, Bruce A Koplan, Gregory F Michaud, Roy M John, William G Stevenson, Usha B Tedrow
AIMS: Catheter ablation can be lifesaving in ventricular tachycardia (VT) storm, but the underlying substrate in patients with storm is not well characterized. We sought to compare the clinical factors, substrate and outcomes differences in patients with sustained monomorphic VT who present for catheter ablation with VT storm versus those with a non-storm presentation. METHODS: Consecutive ischemic (ICM; n = 554) or non-ischemic cardiomyopathy patients (NICM; n = 369) with a storm vs...
October 26, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27781295/3d-cohort-study-the-integrated-research-network-in-perinatology-of-quebec-and-eastern-ontario
#20
William D Fraser, Gabriel D Shapiro, François Audibert, Lise Dubois, Jean-Charles Pasquier, Pierre Julien, Anick Bérard, Gina Muckle, Jacquetta Trasler, Richard E Tremblay, Haim Abenhaim, Michel Welt, Marie-Josée Bédard, François Bissonnette, Emmanuel Bujold, Robert Gagnon, Jacques L Michaud, Isabelle Girard, Jean-Marie Moutquin, Isabelle Marc, Patricia Monnier, Jean R Séguin, Zhong-Cheng Luo
BACKGROUND: The 3D Cohort Study (Design, Develop, Discover) was established to help bridge knowledge gaps about the links between various adverse exposures during pregnancy with birth outcomes and later health outcomes in children. METHODS: Pregnant women and their partners were recruited during the first trimester from nine sites in Quebec and followed along with their children through to 2 years of age. Questionnaires were administered during pregnancy and post-delivery to collect information on demographics, mental health and life style, medical history, psychosocial measures, diet, infant growth, and neurodevelopment...
November 2016: Paediatric and Perinatal Epidemiology
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