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https://www.readbyqxmd.com/read/29345414/molecular-characterization-of-a-series-of-990-index-patients-with-albinism
#1
E Lasseaux, C Plaisant, V Michaud, P Pennamen, A Trimouille, L Gaston, S Monfermé, D Lacombe, C Rooryck, F Morice-Picard, B Arveiler
Albinism is a clinically and genetically heterogeneous disease characterized by variable degrees of hypopigmentation and by nystagmus, foveal hypoplasia, and chiasmatic misrouting of the optic nerves. The wide phenotypic heterogeneity impedes the establishment of phenotype-genotype correlations. In order to obtain a precise diagnosis we screened the 19 known albinism genes in 990 index patients using targeted next generation sequencing (NGS) and high resolution comparative genomic hybridization. A molecular diagnosis was obtained in 72...
January 18, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29342333/ce-n-est-pas-la-joie-tous-ces-cris-%C3%A3-tude-pilote-sur-une-d%C3%A3-marche-d-interventions-pour-les-personnes-%C3%A3-g%C3%A3-es-vivant-avec-la-maladie-d-alzheimer
#2
Anne Bourbonnais, Francine Ducharme, Philippe Landreville, Cécile Michaud, Marie-Andrée Gauthier, Marie-Hélène Lavallée
No abstract text is available yet for this article.
January 2018: Perspective Infirmière: Revue Officielle de L'Ordre des Infirmières et Infirmiers du Québec
https://www.readbyqxmd.com/read/29342299/benefit-of-left-atrial-appendage-electrical-isolation-for-persistent-and-long-standing-persistent-atrial-fibrillation-a-systematic-review-and-meta-analysis
#3
Jorge Romero, Gregory F Michaud, Ricardo Avendano, David F Briceño, Saurabh Kumar, Juan Carlos Diaz, Sanghamitra Mohanty, Chintan Trivedi, Carola Gianni, Domenico Della Rocca, Riccardo Proietti, Laura Perrotta, Stefano Bordignon, Julian K R Chun, Boris Schmidt, Mario Garcia, Andrea Natale, Luigi Di Biase
Aims: The long-term outcomes of left atrial appendage electrical isolation (LAAEI) in patients with non-paroxysmal atrial fibrillation (AF) have corroborated the significant role of the LAA in this arrhythmia. We sought to investigate the incremental benefit of LAAEI in patients undergoing catheter ablation for persistent AF or long-standing persistent AF (LSPAF). Methods and results: A systematic review of Medline, Cochrane, and Embase for all the clinical studies in which assessment LAAEI in non-paroxysmal AF patients was performed...
January 12, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29342298/periodontal-disease-assessed-using-clinical-dental-measurements-and-cancer-risk-in-the-aric-study
#4
Dominique S Michaud, Jiayun Lu, Alexandra Y Peacock-Villada, John R Barber, Corinne E Joshu, Anna E Prizment, James D Beck, Steven Offenbacher, Elizabeth A Platz
Background: While evidence is increasingly consistent with a positive association between periodontitis and cancer risk, most studies have relied on self-reported periodontitis. In this study, we prospectively evaluated the association of periodontal disease severity with cancer risk in black and white older adults in a cohort study that included a dental examination. Methods: Included were 7466 participants in the Atherosclerosis Risk in Communities study cohort who at visit 4 (1996-1998) reported being edentulous or underwent the dental examination...
January 12, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29332165/factors-associated-with-anxiety-about-colonoscopy-the-preparation-the-procedure-and-the-anticipated-findings
#5
L A Shafer, J R Walker, C Waldman, C Yang, V Michaud, C N Bernstein, L Hathout, J Park, J Sisler, G Restall, K Wittmeier, H Singh
BACKGROUND: Previous research has assessed anxiety around colonoscopy procedures, but has not considered anxiety related to different aspects related to the colonoscopy process. AIMS: Before colonoscopy, we assessed anxiety about: bowel preparation, the procedure, and the anticipated results. We evaluated associations between patient characteristics and anxiety in each area. METHODS: An anonymous survey was distributed to patients immediately prior to their outpatient colonoscopy in six hospitals and two ambulatory care centers in Winnipeg, Canada...
January 13, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29325902/which-data-should-be-tracked-in-forward-dynamic-optimisation-to-best-predict-muscle-forces-in-a-pathological-co-contraction-case
#6
Colombe Bélaise, Benjamin Michaud, Fabien Dal Maso, Katja Mombaur, Mickaël Begon
The choice of the cost-function for predicting muscle forces during a movement remains a challenge, especially in patients with neuromuscular disorders. Forward dynamics-based optimisations mainly track joint kinematics or torques, combined with a least-excitation criterion. Tracking marker trajectories and/or electromyography (EMG) has rarely been proposed. Our objective was to determine the best tracking objective-function to accurately predict the upper-limb muscle forces. A musculoskeletal model was created and EMG was simulated to obtain a reference movement - a shoulder abduction...
January 4, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29300783/the-economic-benefits-of-reducing-cardiovascular-disease-mortality-in-quebec-canada
#7
David Boisclair, Yann Décarie, François Laliberté-Auger, Pierre-Carl Michaud, Carole Vincent
OBJECTIVES: We assess how different scenarios of cardiovascular disease (CVD) prevention, aimed at meeting targets set by the World Health Organization (WHO) for 2025), may impact healthcare spending in Quebec, Canada over the 2050 horizon. METHODS: We provide long-term forecasts of healthcare use and costs at the Quebec population level using a novel dynamic microsimulation model. Using both survey and administrative data, we simulate the evolution of the Quebec population's health status until death, through a series of dynamic transitions that accounts for social and demographic characteristics associated with CVD risk factors...
2018: PloS One
https://www.readbyqxmd.com/read/29299746/laryngotracheal-anomalies-associated-with-esophageal-atresia-importance-of-early-diagnosis
#8
Pierre Fayoux, Martin Morisse, Rony Sfeir, Laurent Michaud, Sam Daniel
OBJECTIVE: Esophageal atresia (EA) is the most common congenital esophageal malformation. Airway pathology, in particular, tracheomalacia and laryngotracheal anomalies is a major cause of morbidity and mortalilty in patients with EA. The aim of this study was to report the incidence and type of laryngotracheal anomalies seen in a large series of patients with EA, and to evaluate their impact on the management of children with EA. STUDY DESIGN: Retrospective study...
January 4, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29290646/integrating-watershed-hydrology-and-economics-to-establish-a-local-market-for-water-quality-improvement-a-field-experiment
#9
Emi Uchida, Stephen K Swallow, Arthur Gold, James Opaluch, Achyut Kafle, Nathaniel Merrill, Clayton Michaud, Carrie Anne Gill
Innovative market mechanisms are being increasingly recognized as effective decision-making institutions to incorporate the value of ecosystem services into the economy. We present a field experiment that integrates an economic auction and a biophysical water flux model to develop a local market process consisting of both the supply and demand sides. On the supply side, we operate an auction with small-scale livestock owners who bid for contracts to implement site-specific manure management practices that reduce phosphorus loadings to a major reservoir...
April 1, 2018: Ecological Economics: the Journal of the International Society for Ecological Economics
https://www.readbyqxmd.com/read/29290168/the-economic-burden-of-acpa-positive-status-among-patients-with-rheumatoid-arthritis
#10
Jason Shafrin, Mahlet Gizaw Tebeka, Kwanza Price, Chad Patel, Kaleb Michaud
BACKGROUND: Anticitrullinated protein antibodies (ACPAs) are serological biomarkers associated with early, rapidly progressing rheumatoid arthritis (RA), including more severe disease and joint damage. ACPA testing has become a routine tool for RA diagnosis and prognosis. Furthermore, treatment efficacy has been shown to vary by ACPA-positive status. However, it is not clear if the economic burden of patients with RA varies by ACPA status. OBJECTIVE: To determine if the economic burden of RA varies by patient ACPA status...
January 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29287944/prediction-of-early-adverse-events-in-emergency-department-patients-with-acute-heart-failure-a-systematic-review
#11
REVIEW
Allison M Michaud, Shannon I A Parker, Heather Ganshorn, Justin A Ezekowitz, Andrew D McRae
BACKGROUND: Acute heart failure (AHF) accounts for a substantial proportion of Emergency Department (ED) visits and hospitalizations. Previous studies have shown that emergency physicians' clinical gestalt is not sufficient to stratify patients with AHF into severe and requiring hospitalization vs nonsevere and safe to be discharged. Various prognostic algorithms have been developed to risk-stratify patients with AHF, however there is no consensus as to the best-performing risk assessment tool in the ED...
September 12, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29282723/comparison-of-electronic-health-record-based-and-claims-based-diabetes-care-quality-measures-causes-of-discrepancies
#12
Michael Barton Laws, Joanne Michaud, Renee Shield, William McQuade, Ira B Wilson
OBJECTIVE: To investigate magnitude and sources of discrepancy in quality metrics using claims versus electronic health record (EHR) data. STUDY DESIGN: Assessment of proportions of HbA1c and LDL testing for people ascertained as diabetic from the respective sources. Qualitative interviews and review of EHRs of discrepant cases. DATA COLLECTION/EXTRACTION: Claims submitted to Rhode Island Medicaid by three practice sites in 2013; program-coded EHR extraction; manual review of selected EHRs...
December 28, 2017: Health Services Research
https://www.readbyqxmd.com/read/29275864/association-of-tobacco-use-alcohol-consumption-and-her2-polymorphisms-with-response-to-trastuzumab-in-her2-positive-breast-cancer-patients
#13
Daniela Furrer, Simon Jacob, Annick Michaud, Louise Provencher, Julie Lemieux, Caroline Diorio
PURPOSE: Although the administration of trastuzumab has improved the survival of human epidermal growth factor receptor 2 (HER2)-positive breast cancer patients, resistance remains a major clinical obstacle. We retrospectively evaluated the association of HER2 polymorphisms, tobacco use and alcohol consumption with disease-free survival (DFS) in HER2-positive breast cancer patients. PATIENTS AND METHODS: Clinicopathologic and survival data (median follow-up, 7.4 years) were collected from medical records for 236 nonmetastatic trastuzumab-treated HER2-positive breast cancer patients...
November 23, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29261186/genomic-study-of-severe-fetal-anomalies-and-discovery-of-greb1l-mutations-in-renal-agenesis
#14
Sarah Boissel, Catherine Fallet-Bianco, David Chitayat, Valérie Kremer, Christina Nassif, Françoise Rypens, Marie-Ange Delrue, Dorothée Dal Soglio, Luc L Oligny, Natalie Patey, Elisabeth Flori, Mireille Cloutier, David Dyment, Philippe Campeau, Aspasia Karalis, Sonia Nizard, William D Fraser, François Audibert, Emmanuelle Lemyre, Guy A Rouleau, Fadi F Hamdan, Zoha Kibar, Jacques L Michaud
PurposeFetal anomalies represent a poorly studied group of developmental disorders. Our objective was to assess the impact of whole-exome sequencing (WES) on the investigation of these anomalies.MethodsWe performed WES in 101 fetuses or stillborns who presented prenatally with severe anomalies, including renal a/dysgenesis, VACTERL association (vertebral defects, anal atresia, cardiac defects, tracheoesophageal fistula, renal anomalies, and limb abnormalities), brain anomalies, suspected ciliopathies, multiple major malformations, and akinesia...
October 26, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29244838/muscle-function-in-glenohumeral-joint-stability-during-lifting-task
#15
Yoann Blache, Mickaël Begon, Benjamin Michaud, Landry Desmoulins, Paul Allard, Fabien Dal Maso
Ensuring glenohumeral stability during repetitive lifting tasks is a key factor to reduce the risk of shoulder injuries. Nevertheless, the literature reveals some lack concerning the assessment of the muscles that ensure glenohumeral stability during specific lifting tasks. Therefore, the purpose of this study was to assess the stabilization function of shoulder muscles during a lifting task. Kinematics and muscle electromyograms (n = 9) were recorded from 13 healthy adults during a bi-manual lifting task performed from the hip to the shoulder level...
2017: PloS One
https://www.readbyqxmd.com/read/29237608/significance-of-inducible-nonsustained-ventricular-tachycardias-after-catheter-ablation-for-ventricular-tachycardia-in-ischemic-cardiomyopathy
#16
Akira Fujii, Koichi Nagashima, Saurabh Kumar, Shinichi Tanigawa, Samuel H Baldinger, Gregory F Michaud, Roy M John, Bruce A Koplan, Michifumi Tokuda, Keiichi Inada, Usha B Tedrow, William G Stevenson
BACKGROUND: Noninducibility of sustained monomorphic ventricular tachycardia (SMVT) postablation does not insure absence of later recurrence in patients with ischemic cardiomyopathy. This study aims to determine the relation between inducible nonsustained VT postablation and VT recurrences. METHODS AND RESULTS: One hundred sixty-five consecutive patients (156 male; age 68±9 years) underwent ablation for SMVT because of ischemic cardiomyopathy; 44 patients who did not have induction testing or in whom only ventricular fibrillation was induced after ablation were excluded...
December 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29220561/le-mapa-au-coeur-du-diagnostic-et-du-suivi-de-l-hypertension-art%C3%A3-rielle
#17
André Michaud, Maxime Lamarre-Cliche, Alain Milot, Josyane Pinard, Luc Poirier, Lyne Cloutier
No abstract text is available yet for this article.
May 2017: Perspective Infirmière: Revue Officielle de L'Ordre des Infirmières et Infirmiers du Québec
https://www.readbyqxmd.com/read/29212672/cardiovascular-response-to-prescribed-detraining-among-recreational-athletes
#18
Charles Richard Pedlar, Marcel G Brown, Robert E Shave, James M Otto, Aimee Drane, Jennifer Michaud-Finch, Miranda Contursi, Meagan M Wasfy, Adolph Hutter, Michael H Picard, Gregory D Lewis, Aaron L Baggish
Exercise-induced cardiac remodeling (EICR) and the attendant myocardial adaptations characteristic of the athlete's heart may regress during periods of exercise reduction or abstinence. The time course and mechanisms underlying this reverse remodeling, specifically the impact of concomitant plasma volume (PV) contraction on cardiac chamber size, remain incompletely understood. We therefore studied recreational runners (n=21, aged 34 ± 7 years; 48% male) who completed an 18-week training program (~7 h.w-1) culminating in the 2016 Boston Marathon after which total exercise exposure was confined to <2 h...
December 6, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29200128/tro40303-ameliorates-alcohol-induced-pancreatitis-through-reduction-of-fatty-acid-ethyl-ester-induced-mitochondrial-injury-and-necrotic-cell-death
#19
Muhammad Ahsan Javed, Li Wen, Muhammad Awais, Diane Latawiec, Wei Huang, Michael Chvanov, Sophie Schaller, Thierry Bordet, Magali Michaud, Rebecca Pruss, Alexei Tepikin, David Criddle, Robert Sutton
OBJECTIVES: Mitochondrial permeability transition pore inhibition is a promising approach to treat acute pancreatitis (AP). We sought to determine (i) the effects of the mitochondrial permeability transition pore inhibitor 3,5-seco-4-nor-cholestan-5-one oxime-3-ol (TRO40303) on murine and human pancreatic acinar cell (PAC) injury induced by fatty acid ethyl esters (FAEEs) or taurolithocholic acid-3-sulfate and (ii) TRO40303 pharmacokinetics and efficacy in experimental alcoholic AP (FAEE-AP)...
December 2, 2017: Pancreas
https://www.readbyqxmd.com/read/29198250/cornicle-secretions-by-aphis-fabae-hemiptera-aphididae-result-in-age-dependent-costs-and-improved-host-suitability-for-lysiphlebus-fabarum-marshall-hymenoptera-braconidae
#20
Y Parvizi, A Rasekh, J P Michaud
We examined the life history consequences of cornicle secretion by Aphis fabae Scopoli in second and fourth instars, and its effects on host suitability for its parasitoid, Lysiphlebus fabarum (Marshall). Cornicle secretion did not affect aphid fecundity, but secretion in the second instar enhanced life table parameters, whereas secretion in the fourth instar affected them negatively, suggesting a higher cost of secretion in later instars. Secretion in either instar improved host suitability for L. fabarum...
December 4, 2017: Bulletin of Entomological Research
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