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https://www.readbyqxmd.com/read/28211476/novel-roles-for-staufen1-in-embryonal-and-alveolar-rhabdomyosarcoma-via-c-myc-dependent-and-independent-events
#1
Tara E Crawford Parks, Kristen A Marcellus, Jonathan Langill, Aymeric Ravel-Chapuis, Jean Michaud, Kyle N Cowan, Jocelyn Côté, Bernard J Jasmin
Rhabdomyosarcoma is the most common soft tissue sarcoma in children and young adults. Rhabdomyosarcomas are skeletal muscle-like tumours that typically arise in muscle beds, and express key myogenic regulatory factors. However, their developmental program remains blocked in the proliferative phase with cells unable to exit the cell cycle to fuse into myotubes. Recently, we uncovered a key role for the RNA-binding protein Staufen1 during myogenic differentiation through the regulation of c-myc translation. Given the known implication of c-myc in rhabdomyosarcoma, we hypothesized in the current work that Staufen1 controls rhabdomyosarcoma tumorigenesis...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28205838/p-09-recurrent-tracheoesophageal-fistula-in-esophageal-atresia-a-multicenter-study
#2
M R Revillion, F G Gottrand, L M Michaud
No abstract text is available yet for this article.
April 1, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28205739/p-25-risk-factors-for-morbidity-and-mortality-in-esophageal-atresia-type-iii-data-from-a-population-based-register
#3
R S Sfeir, B A Bonnard, R V Rousseaux, G T Gelas, M L Michaud, K H Kotobi, D S Denapoli, B A Breton, P C Piolat, L J L Lemelle, F V Fouquet, H E Habonimana, P M L Polimerol, M J L Michel, B F Becmeur, P T Petit, L F Lavrand, E F Elbaz, A H Allal, L E Lopez, M T Merrot, B P Buisson, B J Borgnon, D P Delagausie, L G Levard, P G Podevin, L H Lardy, A F Auber, B C Borderon, P C Pelatan, J O Jaby, B J Bréaud, F L Fourcade, P M Pouzac, G S Gueiss, T C Tolg, L C Laplace, L C Langlois, G F Gottrand
No abstract text is available yet for this article.
April 1, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28205718/p-31-esophageal-replacement-by-a-tissue-engineered-substitute-in-a-porcine-model
#4
T Poghosyan, R Sfeir, L Michaud, P Bruneval, M Luong-Nguyen, T Dommet, V Vanneaux, S Gaujoux, J Larghero, F Gottrand, P Cattan
No abstract text is available yet for this article.
April 1, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28205690/o-10-11-50-to-12-02-prevalence-of-barrett-esophagus-in-adolescents-and-young-adults-with-esophageal-atresia
#5
A Schneider, F Gottrand, M Bellaiche, F Becmeur, A Lachaux, A Dabadie, J L Michel, C Faure, P Philippe, Y Vandenplas, C Dupont, A Breton, J Gaudin, T Lamireau, L Muyshont, G Podevin, S Viola, V Bertrand, D Caldari, S Colinet, E Sokal, E Sauleau, E Leteurtre, L Michaud
No abstract text is available yet for this article.
April 1, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28183061/trace-elements-in-oceanic-pelagic-communities-in-the-western-indian-ocean
#6
Nathalie Bodin, Dora Lesperance, Rona Albert, Stephanie Hollanda, Philippe Michaud, Maxime Degroote, Carine Churlaud, Paco Bustamante
The mineral composition of target and non-target pelagic fish caught by purse-seiners and longliners in the western-central Indian Ocean was determined. From the 10 essential elements analysed, selenium and zinc showed the highest concentrations in swordfish and blue marlin while Indian mackerel appeared as a good source of copper, iron and chrome. All catch had levels of lead and cadmium, two toxic elements, below the maximum sanitary limits. Although some concerns were raised regarding mercury concentrations in the largest species (wahoo, swordfish and blue marlin), molar ratios of mercury and selenium indicate that all oceanic pelagic fish from the western-central Indian Ocean are safe for human consumption...
January 21, 2017: Chemosphere
https://www.readbyqxmd.com/read/28167697/prc2-is-dispensable-for-hotair-mediated-transcriptional-repression
#7
Manuela Portoso, Roberta Ragazzini, Živa Brenčič, Arianna Moiani, Audrey Michaud, Ivaylo Vassilev, Michel Wassef, Nicolas Servant, Bruno Sargueil, Raphaël Margueron
Long non-coding RNAs (lncRNAs) play diverse roles in physiological and pathological processes. Several lncRNAs have been suggested to modulate gene expression by guiding chromatin-modifying complexes to specific sites in the genome. However, besides the example of Xist, clear-cut evidence demonstrating this novel mode of regulation remains sparse. Here, we focus on HOTAIR, a lncRNA that is overexpressed in several tumor types and previously proposed to play a key role in gene silencing through direct recruitment of Polycomb Repressive Complex 2 (PRC2) to defined genomic loci...
February 6, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28160834/-observational-study-of-delirium-in-palliative-care
#8
REVIEW
Maryse Mailly, Jean-Pierre Bénézech, Josyane Chevallier-Michaud
Caregivers know that the agitation and movements to reject sheets and clothes is found in some patients with cancer in the palliative phase. An observational study was carried out with the aim of refining the short-term prognosis clinical approach and to organise more suitably adapted care.
February 2017: Revue de L'infirmière
https://www.readbyqxmd.com/read/28154964/facilitation-may-not-be-an-adequate-mechanism-of-community-succession-on-carrion
#9
Jean-Philippe Michaud, Gaétan Moreau
The facilitation model of ecological succession was advanced by plant ecologists in the late 1970s and was then introduced to carrion ecology in the late 1980s, without empirical evidence of its applicability. Ecologists in both disciplines proposed removing early colonists, in this case fly eggs and larvae, from the substrate to determine whether other species could still colonize, which to our knowledge has never been attempted. Here, we tested the facilitation model in a carrion system by removing fly eggs and larvae from carcasses that were exposed in agricultural fields and assigned to one of the following treatment levels of removal intensity: 0, <5, 50, and 100%...
February 2, 2017: Oecologia
https://www.readbyqxmd.com/read/28130329/bacteriophages-targeting-adherent-invasive-escherichia-coli-strains-as-a-promising-new-treatment-for-crohn-s-disease
#10
Matthieu Galtier, Luisa De Sordi, Adeline Sivignon, Amélie de Vallée, Damien Maura, Christel Neut, Oumaira Rahmouni, Kristin Wannerberger, Arlette Darfeuille-Michaud, Pierre Desreumaux, Nicolas Barnich, Laurent Debarbieux
BACKGROUND AND AIMS: Adherent invasive Escherichia coli (AIEC) are abnormally predominant on the ileal mucosa of Crohn's disease (CD) patients. They bind to the CEACAM6 receptor expressed on the surface of epithelial cells. We aimed to assess the potential of bacteriophages, viruses infecting bacteria, to decrease the levels of AIEC bacteria associated with the intestinal mucosa. METHODS: We combined ex vivo and in vivo experiments with murine and human intestinal samples to quantify the ability of virulent bacteriophages to target the prototype AIEC strain LF82...
January 27, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28122195/an-epidemiological-model-of-internet-worms-with-hierarchical-dispersal-and-spatial-clustering-of-hosts
#11
David E Hiebeler, Andrew Audibert, Emma Strubell, Isaac J Michaud
Beginning in 2001, many instances of malicious software known as Internet worms have been using biological strategies such as hierarchical dispersal to seek out and spread to new susceptible hosts more efficiently. We measured the distribution of potentially susceptible hosts in the space of Internet addresses to determine their clustering. We have used the results to construct a full-size simulated Internet with 2(32) hosts with mean and variance of susceptible hosts chosen to match our measurements at multiple spatial scales...
January 22, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28115468/live-cell-analysis-of-dna-methylation-during-sexual-reproduction-in-arabidopsis-reveals-context-and-sex-specific-dynamics-controlled-by-noncanonical-rddm
#12
Mathieu Ingouff, Benjamin Selles, Caroline Michaud, Thiet M Vu, Frédéric Berger, Andrea J Schorn, Daphné Autran, Matthias Van Durme, Moritz K Nowack, Robert A Martienssen, Daniel Grimanelli
Cytosine methylation is a key epigenetic mark in many organisms, important for both transcriptional control and genome integrity. While relatively stable during somatic growth, DNA methylation is reprogrammed genome-wide during mammalian reproduction. Reprogramming is essential for zygotic totipotency and to prevent transgenerational inheritance of epimutations. However, the extent of DNA methylation reprogramming in plants remains unclear. Here, we developed sensors reporting with single-cell resolution CG and non-CG methylation in Arabidopsis...
January 1, 2017: Genes & Development
https://www.readbyqxmd.com/read/28104479/benefits-of-non-vitamin-k-antagonist-oral-anticoagulants-in-patients-with-atrial-fibrillation-go-beyond-stroke-prevention
#13
EDITORIAL
Jay A Montgomery, Gregory F Michaud
No abstract text is available yet for this article.
January 16, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28092362/the-role-of-endothelial-hif-1-%C3%AE-in-the-response-to-sublethal-hypoxia-in-c57bl-6-mouse-pups
#14
Qi Li, Michael Michaud, Chan Park, Yan Huang, Rachael Couture, Frank Girodano, Michael L Schwartz, Joseph A Madri
Chronic sublethal hypoxia, a complication of premature birth, is associated with cognitive and motor handicaps. Responsiveness to and recovery from this hypoxic environment is dependent on induction of HIF-1 α in the cells affected. Microvascular endothelial-glial and microvascular endothelial-neuronal precursor interactions have been found to be dynamic and reciprocal, involving autocrine and paracrine signaling, with response and recovery correlated with baseline levels and levels of induction of HIF-1 α...
January 16, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28073905/feeding-by-melanaphis-sacchari-hemiptera-aphididae-facilitates-use-of-sorghum-by-rhopalosiphum-padi-hemiptera-aphididae-but-reciprocal-effects-are-negative
#15
J P Michaud, Yun Zhang, Clint Bain
In the process of feeding, aphids modify the physiology of their host plants in species-specific ways, and plant responses to these aggressions are often genotype- or cultivar-specific. Thus, different aphid species sharing a host can influence each other's fitness via plant-mediated interactions, usually with negative and asymmetric impacts. Here, we show that feeding by the sugarcane aphid, Melanaphis sacchari Zehntner, can improve the suitability of sorghum as a host plant for the bird cherry-oat aphid, Rhopalosiphum padi L...
January 10, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/28073775/dasatinib-changes-immune-cell-profiles-concomitant-with-reduced-tumor-growth-in-several-murine-solid-tumor-models
#16
Can Hekim, Mette Ilander, Jun Yan, Erin Michaud, Richard Smykla, Markus Vähä-Koskela, Paula Savola, Siri Tähtinen, Leena Saikko, Akseli Hemminki, Panu E Kovanen, Kimmo Porkka, Francis Y F Lee, Satu Mustjoki
Dasatinib, a broad-range tyrosine kinase inhibitor, induces rapid mobilization of lymphocytes and clonal expansion of cytotoxic cells in leukemia patients. Here, we investigated whether dasatinib could induce beneficial immunomodulatory effects in solid tumor models. The effects on tumor growth and on the immune system were studied in four different syngeneic mouse models (B16.OVA melanoma, 1956 sarcoma, MC38 colon, and 4T1 breast carcinoma). Both peripheral blood (PB) and tumor samples were immunophenotyped during treatment...
January 10, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28073648/elevated-neutrophil-elastase-in-tears-of-ocular-graft-versus-host-disease-patients
#17
Samer N Arafat, Marie-Claude Robert, Tulio Abud, Sandra Spurr-Michaud, Francisco Amparo, Claes H Dohlman, Reza Dana, Ilene K Gipson
PURPOSE: To investigate the levels of neutrophil elastase (NE), matrix metalloproteinases (MMPs) and myeloperoxidase (MPO) in tear washes of patients with ocular graft-versus-host disease (oGVHD). DESIGN: Case-control study. METHODS: Based on established criteria, oGVHD patients (n = 14; 28 eyes) and age/sex-matched healthy controls (n = 14; 28 eyes) were enrolled. Tear washes were collected and analyzed for NE using a single-analyte enzyme-linked immunosorbent assay (ELISA)...
January 7, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28070875/atrial-fibrillation-inducibility-during-cavotricuspid-isthmus-dependent-atrial-flutter-ablation-as-a-predictor-of-clinical-atrial-fibrillation-a-meta-analysis
#18
Jorge Romero, Juan Carlos Diaz, Luigi Di Biase, Saurabh Kumar, David Briceno, Usha B Tedrow, Carolina R Valencia, Samuel H Baldinger, Bruce Koplan, Laurence M Epstein, Roy John, Gregory F Michaud, William G Stevenson
BACKGROUND: Atrial fibrillation (AF) and cavotricuspid isthmus (CTI)-dependent atrial flutter (AFL) are two separate entities that coexist in a significant percentage of patients. We sought to investigate whether AF inducibility during CTI AFL ablation predicted the occurrence of AF at follow-up after successful AFL ablation. METHODS: A systemic review of Medline, Cochrane, and Embase was done for all the clinical studies in which assessment of AF inducibility in patients undergoing ablation for CTI AFL was performed...
January 9, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28070004/arthrocladium-fulminans-arthritis-and-osteomyelitis
#19
Abdoulahy Diallo, Céline Michaud, Souandou Tabibou, Maxime Raz, Carla Fernandez, Hubert Lepidi, Pierre-Edouard Fournier, Andreas Stein, Stéphane Ranque, Piseth Seng
Arthrocladium fulminans is the only species in the Arthrocladium genus that has been involved in a previous human infection. To date, only one case of A. fulminans infection in a patient with GATA-2 immunodeficiency has been reported. We here report the second human case and the first case of septic arthritis and osteomyelitis due to A. fulminans in an immunocompetent patient, living in Mayotte, a French island in western Indian Ocean. He was successfully treated with surgical debridement and 6 months of antifungal treatment...
January 9, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28054374/determinants-of-heparin-dosing-and-complications-in-patients-undergoing-left-atrial-ablation-on-uninterrupted-rivaroxaban
#20
Alan D Enriquez, Timothy Churchill, Sandeep Gautam, Jason S Chinitz, Chirag R Barbhaiya, Saurabh Kumar, Roy M John, Usha B Tedrow, Bruce A Koplan, William G Stevenson, Gregory F Michaud
BACKGROUND: Patients on rivaroxaban have variable INRs, but it is uncertain if INR impacts procedural heparin requirement during left atrial ablation. We sought to examine the determinants of heparin dosing in this patient population. METHODS: We reviewed consecutive patients who received rivaroxaban within 24 hours of left atrial ablation and compared them to patients on uninterrupted warfarin. The determinants of heparin requirement were evaluated using regression analysis...
January 5, 2017: Pacing and Clinical Electrophysiology: PACE
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