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Flore Amat, Pauline Tallon, Anne-Perrine Foray, Bénédicte Michaud, Nathalie Lambert, Philippe Saint-Pierre, Lucienne Chatenoud, Jocelyne Just
Allergic asthma is an inflammatory disease of the airways, resulting from an inappropriate immune response to inhaled allergens, which involves multiple inflammatory cells and mediators that contribute to airway hyper-responsiveness. Omalizumab is a monoclonal antibody, specifically directed to the C-Epsilon3 domain of immunoglobulin E (IgE), indicated as an additional therapy in severe allergic asthma [1]. Impaired function of regulatory T cells (Treg) is incriminated in the aberrant asthma inflammatory response [2]...
October 22, 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Kaleb Michaud
The National Data Bank for Rheumatic Diseases (NDB) is a longitudinal observational patient-driven database, founded as a non-profit research organization in 1998 by Dr. Frederick Wolfe. Patients are sent a primary questionnaire twice a year. More than 50,000 patients with more than 100 various rheumatic diseases under the care of more than 1,500 rheumatologists have completed at least one 6-month questionnaire. Many important publications concerning rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus, fibromyalgia, and pharmaco-epidemiology have resulted from NDB research...
September 2016: Clinical and Experimental Rheumatology
Thomas Young Ho Yoon, Richard A Michaud, Mitesh Patel, Alexandra M Manibo
OBJECTIVE: This study was conducted to evaluate variations in and the prevalence of the lingual concavity. MATERIALS & METHODS: This study used images taken between January 1st, 2011 and August 31st, 2015 from a total of 104 patient charts randomly selected from a private practice. These images were all acquired from a single cone beam computed tomography (CBCT) machine. The CBCT's were reviewed in cross sectional images of both the left and right anterior incisor and posterior molar regions...
October 19, 2016: Journal of Oral Implantology
Demosthenes G Katritsis, Joseph E Marine, Fernando M Contreras, Akira Fujii, Rakesh Latchamsetty, Konstantinos C Siontis, George D Katritsis, Theodoros A Zografos, Roy M John, Laurence M Epstein, Gregory F Michaud, Elad Anter, Ali Sepahpour, Edward Rowland, Alfred E Buxton, Hugh Calkins, Fred Morady, William G Stevenson, Mark E Josephson
BACKGROUND: -Due to its low prevalence, data on atypical atrioventricular nodal reentrant tachycardia (AVNRT) are scarce, and the optimal ablation method is not established. Our study aimed at assessing the efficacy and safety of conventional slow pathway ablation, as applied for typical cases, in atypical AVNRT. METHODS: -We studied 2079 patients with AVNRT subjected to slow pathway ablation. In 113 patients, mean age 48.5±18.1 years, 68 female, atypical AVNRT or co-existent atypical and typical AVNRT without other concomitant arrhythmia was diagnosed...
October 17, 2016: Circulation
Farah R Zahir, Tracy Tucker, Sonia Mayo, Carolyn J Brown, Emilia L Lim, Jonathan Taylor, Marco A Marra, Fadi F Hamdan, Jacques L Michaud, Jan M Friedman
The disruption of genes involved in epigenetic regulation is well known to cause Intellectual Disability (ID). We reported a custom microarray study that interrogated among others, the epigenetic regulatory gene-class, at single exon resolution. Here we elaborate on identified intragenic CNVs involving epigenetic regulatory genes; specifically discussing those in three genes previously unreported in ID etiology-ARID2, KDM3A, and ARID4B. The changes in ARID2 and KDM3A are likely pathogenic while the ARID4B variant is uncertain...
November 2016: American Journal of Medical Genetics. Part A
G Veronesi, A Deniaud, T Gallon, P-H Jouneau, J Villanova, P Delangle, M Carrière, I Kieffer, P Charbonnier, E Mintz, I Michaud-Soret
Silver nanoparticles (AgNPs) can enter eukaryotic cells and exert toxic effects, most probably as a consequence of the release of Ag(+) ions. Due to the elusive nature of Ag(+) ionic species, quantitative information concerning AgNP intracellular dissolution is missing. By using a synchrotron nanoprobe, silver is visualized and quantified in hepatocytes (HepG2) exposed to AgNPs; the synergistic use of electron microscopy allows for the discrimination between nanoparticular and ionic forms of silver within a single cell...
September 29, 2016: Nanoscale
Solveig K Sieberts, Fan Zhu, Javier García-García, Eli Stahl, Abhishek Pratap, Gaurav Pandey, Dimitrios Pappas, Daniel Aguilar, Bernat Anton, Jaume Bonet, Ridvan Eksi, Oriol Fornés, Emre Guney, Hongdong Li, Manuel Alejandro Marín, Bharat Panwar, Joan Planas-Iglesias, Daniel Poglayen, Jing Cui, Andre O Falcao, Christine Suver, Bruce Hoff, Venkat S K Balagurusamy, Donna Dillenberger, Elias Chaibub Neto, Thea Norman, Tero Aittokallio, Muhammad Ammad-Ud-Din, Chloe-Agathe Azencott, Víctor Bellón, Valentina Boeva, Kerstin Bunte, Himanshu Chheda, Lu Cheng, Jukka Corander, Michel Dumontier, Anna Goldenberg, Peddinti Gopalacharyulu, Mohsen Hajiloo, Daniel Hidru, Alok Jaiswal, Samuel Kaski, Beyrem Khalfaoui, Suleiman Ali Khan, Eric R Kramer, Pekka Marttinen, Aziz M Mezlini, Bhuvan Molparia, Matti Pirinen, Janna Saarela, Matthias Samwald, Véronique Stoven, Hao Tang, Jing Tang, Ali Torkamani, Jean-Phillipe Vert, Bo Wang, Tao Wang, Krister Wennerberg, Nathan E Wineinger, Guanghua Xiao, Yang Xie, Rae Yeung, Xiaowei Zhan, Cheng Zhao, Jeff Greenberg, Joel Kremer, Kaleb Michaud, Anne Barton, Marieke Coenen, Xavier Mariette, Corinne Miceli, Nancy Shadick, Michael Weinblatt, Niek de Vries, Paul P Tak, Danielle Gerlag, Tom W J Huizinga, Fina Kurreeman, Cornelia F Allaart, S Louis Bridges, Lindsey Criswell, Larry Moreland, Lars Klareskog, Saedis Saevarsdottir, Leonid Padyukov, Peter K Gregersen, Stephen Friend, Robert Plenge, Gustavo Stolovitzky, Baldo Oliva, Yuanfang Guan, Lara M Mangravite
No abstract text is available yet for this article.
October 10, 2016: Nature Communications
Amanda M Achberger, Brent C Christner, Alexander B Michaud, John C Priscu, Mark L Skidmore, Trista J Vick-Majors
Subglacial Lake Whillans (SLW) is located beneath ∼800 m of ice on the Whillans Ice Stream in West Antarctica and was sampled in January of 2013, providing the first opportunity to directly examine water and sediments from an Antarctic subglacial lake. To minimize the introduction of surface contaminants to SLW during its exploration, an access borehole was created using a microbiologically clean hot water drill designed to reduce the number and viability of microorganisms in the drilling water. Analysis of 16S rRNA genes (rDNA) amplified from samples of the drilling and borehole water allowed an evaluation of the efficacy of this approach and enabled a confident assessment of the SLW ecosystem inhabitants...
2016: Frontiers in Microbiology
Sheldon M Singh, Andre d'Avila, Young-Hoon Kim, Arash Aryana, J Michael Mangrum, Gregory F Michaud, Srinivas R Dukkipati, Conor D Barrett, E Kevin Heist, Michael K Parides, Kevin E Thorpe, Vivek Y Reddy
AIMS: Controversy on the optimal ablation strategy for persistent atrial fibrillation (AF) exists with limited work evaluating a strategy of pulmonary vein isolation (PVI) alone when AF terminates during PVI. Thirty-five patients had AF termination during PVI in the Modified Ablation Guided by Ibutilide Use in Chronic Atrial Fibrillation (MAGIC-AF; number: NCT01014741) study. The objective of the current study is to report the 1-year outcome after PVI alone in this unique patient group...
October 4, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
A Michaud, J Tordjman, M Pelletier, Y Liu, S Laforest, S Noël, G Le Naour, C Bouchard, K Clément, A Tchernof
BACKGROUND: Adipose tissue fibrosis is a relatively new notion and its relationship with visceral obesity and cardiometabolic alterations remains unclear, particularly in moderate obesity. OBJECTIVE: Our objective was to examine if total and pericellular collagen accumulation are relevant for the pathophysiology of visceral obesity and related cardiometabolic risk. SUBJECTS AND METHODS: Surgical omental (OM) and subcutaneous (SC) fat samples were obtained in 56 women (age: 47...
October 4, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Pascale Schwab, Harlan Sayles, Debra Bergman, Grant W Cannon, Kaleb Michaud, Ted R Mikuls, Jennifer Barton
OBJECTIVES: Many veterans enrolled in Veterans Affairs (VA) also receive care through other healthcare systems. Both VA and non-VA healthcare use must therefore be considered when conducting research in this population. This study characterized dual care utilization in veterans with rheumatoid arthritis (RA) and explored associations with RA disease activity. METHODS: Through a questionnaire mailed to RA patients at three VA sites, veterans reported medical services by non-VA primary care and subspecialty providers, comorbidities, non-VA medications, and hospitalizations...
October 1, 2016: Arthritis Care & Research
Jinoos Yazdany, Nick Bansback, Megan Clowse, Deborah Collier, Karen Law, Katherine P Liao, Kaleb Michaud, Esi M Morgan, James C Oates, Catalina Orozco, Andreas Reimold, Julia F Simard, Rachel Myslinski, Salahuddin Kazi
BACKGROUND: The Rheumatology Informatics System for Effectiveness (RISE) is a national electronic medical record (EMR)-enabled registry. RISE passively collects data from EMRs of participating practices, provides advanced quality measurement and data analytic capacities, and fulfills national quality reporting requirements. Here we report the registry's architecture and initial data, and demonstrate how RISE is being used to improve the quality of care. METHODS: RISE is a certified Centers for Medicare and Medicaid Services Qualified Clinical Data Registry, allowing collection of data without individual patient informed consent...
October 1, 2016: Arthritis Care & Research
Andrew J Percy, Sarah A Michaud, Armando Jardim, Nicholas J Sinclair, Suping Zhang, Yassene Mohammed, Andrea L Palmer, Darryl B Hardie, Juncong Yang, Andre M LeBlanc, Christoph H Borchers
The mouse is the most commonly used laboratory animal, with more than 14 million mice being used for research each year in North America alone. The number and diversity of mouse models is increasing rapidly through genetic engineering strategies, but detailed characterization of these models is still challenging because most phenotypic information is derived from time-consuming histological and biochemical analyses. To expand the biochemists' toolkit, we generated a set of targeted proteomic assays for mouse plasma and heart tissue, utilizing bottom-up LC/MRM-MS with isotope-labeled peptides as internal standards...
September 30, 2016: Proteomics
J P Michaud, Paulo R R Barbosa, Clint L Bain, Jorge B Torres
Nonconsumptive effects of predators on prey are well known, but similar effects among competing predators are not. Aphidophagous insect larvae are notorious for cannibalism and intraguild predation, as they compete for aggregated but ephemeral prey. We tested for indirect effects of competitors on the development of Coleomegilla maculata DeGeer and Hippodamia convergens Guerin-Meneville (Coleoptera: Coccinellidae), and a green lacewing, Chrysoperla carnea Stephens (Neuroptera: Chrysopidae), with all larvae reared on eggs of Ephestia kuehniella Zeller (Lepidoptera: Pyralidae)...
September 29, 2016: Environmental Entomology
Reza Farivar, Danny Michaud-Landry
Measurements of the fast and precise movements of the eye-critical to many vision, oculomotor, and animal behavior studies-can be made non-invasively by video oculography. The protocol here describes the construction and operation of a research-grade video oculography system with ~0.1° precision over the full typical viewing range at over 450 Hz with tight synchronization with stimulus onset. The protocol consists of three stages: (1) system assembly, (2) calibration for both cooperative, and for minimally cooperative subjects (e...
2016: Frontiers in Systems Neuroscience
Yassene Mohammed, Pallab Bhowmick, Derek S Smith, Dominik Domanski, Angela M Jackson, Sarah A Michaud, Sebastian Malchow, Andrew J Percy, Andrew G Chambers, Andrea Palmer, Suping Zhang, Albert Sickmann, Christoph H Borchers
Targeted proteomics using multiple reaction monitoring (MRM) has become the method of choice for the rapid, precise, and reproducible quantitation of proteins in complex biological matrices. MRM-based targeted proteomics allows protein profiling in complex biological samples and accurate comparisons of between samples [1-6], typically using a bottom-up LC-MS/MS approach [7]. While relative quantitation approaches report differences in fold-changes between the samples being compared, absolute methods measure the concentrations [8], ideally based on isotopically labeled internal standard peptides that are analogues of the endogenous proteotypic target peptides [9]...
September 29, 2016: Proteomics
Tim K Mackey, Jillian Clare Kohler, William D Savedoff, Frank Vogl, Maureen Lewis, James Sale, Joshua Michaud, Taryn Vian
Corruption has been described as a disease. When corruption infiltrates global health, it can be particularly devastating, threatening hard gained improvements in human and economic development, international security, and population health. Yet, the multifaceted and complex nature of global health corruption makes it extremely difficult to tackle, despite its enormous costs, which have been estimated in the billions of dollars. In this forum article, we asked anti-corruption experts to identify key priority areas that urgently need global attention in order to advance the fight against global health corruption...
September 29, 2016: BMC Medicine
B A Dyer, X Zhao, D Hoffman, L Kahn, M Hodges, J T Hayes, A L Michaud, C B Hess, C Kumaran Nair, R C Fragoso, R K Valicenti, J S Mayadev
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Daniel Addison, Hoshang Farhad, Ravi V Shah, Thomas Mayrhofer, Siddique A Abbasi, Roy M John, Gregory F Michaud, Michael Jerosch-Herold, Udo Hoffmann, William G Stevenson, Raymond Y Kwong, Tomas G Neilan
BACKGROUND: The factors that predict recovery of left ventricular (LV) systolic dysfunction among patients with atrial fibrillation (AF) are not completely understood. Late gadolinium enhancement (LGE) of the LV has been reported among patients with AF, and we aimed to test whether the presence LGE was associated with subsequent recovery of LV systolic function among patients with AF and LV dysfunction. METHODS AND RESULTS: From a registry of 720 consecutive patients undergoing a cardiac magnetic resonance study prior to pulmonary vein isolation (PVI), patients with LV systolic dysfunction (ejection fraction [EF] <50%) were identified...
September 26, 2016: Journal of the American Heart Association
Sarmad Al-Karawi, Michael Vassilyadi, Jean Michaud
No abstract text is available yet for this article.
September 2016: Brain Pathology
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