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https://www.readbyqxmd.com/read/29424096/low-education-and-lack-of-spousal-relationship-are-associated-with-dementia-in-older-adults-with-diabetes-mellitus-in-nigeria
#1
Abdulkareem J Yusuf, Olusegun Baiyewu, Adamu G Bakari, Sani B Garko, Mohammed E-B Jibril, Aishatu M Suleiman, Haruna M Muktar, Micheal A Amedu
BACKGROUND: The relationship between dementia and type 2 diabetes mellitus (T2DM) in older adults is well established in the literature. However, there have been few studies on this relationship in older adults living in low- and middle-income countries, and most demographic projections predict that older adult population will increase substantially in these regions by 2050. METHODS: In this study, older adults with T2DM attending a tertiary health facility were examined and compared with community-dwelling older adults without T2DM...
February 8, 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/29407524/metabolic-inflammatory-vascular-comorbidity-in-psychiatric-disorders-soluble-epoxide-hydrolase-seh-as-a-possible-new-target
#2
REVIEW
W Swardfager, M Hennebelle, D Yu, B D Hammock, A J Levitt, K Hashimoto, A Y Taha
The common and severe psychiatric disorders, including major depressive disorder (MDD) and bipolar disorder (BD), are associated with inflammation, oxidative stress and changes in peripheral and brain lipid metabolism. Those pathways are implicated in the premature development of vascular and metabolic comorbidities, which account for considerable morbidity and mortality, including increased dementia risk. During endoplasmic reticulum stress, the soluble epoxide hydrolase (sEH) enzyme converts anti-inflammatory fatty acid epoxides generated by cytochrome p450 enzymes into their corresponding and generally less anti-inflammatory, or even pro-inflammatory, diols, slowing the resolution of inflammation...
February 2, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29338817/correlation-of-stress-hyperglycemia-after-ischemic-stroke-with-early-vascular-cognitive-impairment
#3
Yi Dong Zhou, Huai Wu Yuan, Ren Jie Ji, Ben Yan Luo
Objective To investigate the influence and forecast value of stress hyperglycemia on the early vascular cognitive impairment (VCI) in stroke patients.Methods Totally 422 patients with acute non-diabetic stroke were divided into three groups according to the fasting plasma glucose level:the euglycemia group (<6.1 mmol/L),the mild stress hyperglycemia group (6.1-7.0 mmol/L),and the severe stress hyperglycemia group (≥7.0 mmol/L).Mini-mental state examination,Alzheimer's disease rating scale cognitive subscale,and clinical dementia rating scale were used to evaluate early cognition in post-stroke patients,and patients were divided into three groups accordingly:normal cognitive function group,mild VCI group,and vascular dementia group...
December 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29332036/relationships-between-lower-olfaction-and-brain-white-matter-lesions-in-elderly-subjects-with-mild-cognitive-impairment
#4
Juliette Heinrich, Jean-Sébastien Vidal, Axelle Simon, Anne-Sophie Rigaud, Olivier Hanon, Jacques Epelbaum, Cecile Viollet, Emmanuelle Duron
BACKGROUND: Olfactory impairment is reported in mild cognitive impairment (MCI) and Alzheimer's disease (AD) and is associated with hippocampal atrophy. In elderly people, dementia with AD neuropathology and white matter lesions (WML) is common. In this context, olfactory impairment could also depend on the presence of WML. OBJECTIVE: To assess the cross-sectional relationship between olfaction and WML in elderly subjects with MCI. METHODS: Consecutive subjects, >65 years old, diagnosed as MCI after a comprehensive neuropsychological assessment in an expert memory center, with a brain MRI performed within a year and without major depressive state, were included...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29210283/the-contribution-of-supplementary-tests-in-the-differential-diagnosis-of-dementia
#5
F Moulin de Moraes, P Ferreira Bertolucci
INTRODUCTION: Supplementary tests are part of the clinical approach to diagnose cognitive impairment. We aimed to determine the role of supplementary examinations, except for biomarkers, on diagnostic stability of dementia over time and to identify reversible dementias. METHODS: We identified 432 patients with dementia who performed 2 clinical evaluations and the supplementary examinations recommended by the American Academy of Neurology in a follow-up period of 1 year...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/29203753/-definition-and-treatment-of-stroke-over-the-centuries
#6
Anna Starostka-Tatar, Beata Łabuz-Roszak, Michał Skrzypek, Mariusz Gąsior, Marek Gierlotka
Stroke was already diagnosed in the ancient times. For hundreds of years the treatment of this disease has changed radically. According to the current WHO definition, stroke is a clinical syndrome caused by focal or generalized brain injury that lasts more than 24 hours or leads to death and has no other cause than vascular. Stroke constitutes a big social and economic problem, as it can lead to death or disability. In the highly developed countries stroke is the third most common cause of adult deaths, the second leading cause of dementia, and the most common cause of disability...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29197532/vascular-risk-factor-burden-and-new-onset-depression-in-the-community
#7
Shayna Adams, Sarah Conner, Jayandra J Himali, Alexa Beiser, Ramachandran S Vasan, Sudha Seshadri, Matthew P Pase
Depression is associated with an increased likelihood of cardiac events and stroke. We hypothesized that the vascular risk factor burden might itself predispose to both cardiovascular events and depression. Therefore, we examined whether aggregate scores of vascular risk factor burden were associated with the new-onset of depression in the community. We studied 2023 depression- and dementia-free Framingham Heart Study (Framingham, USA) Offspring participants who attended both examination cycles 7 (1998-2001) and 8 (2005-2008)...
November 29, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29196576/apathy-is-associated-with-incident-dementia-in-community-dwelling-older-people
#8
Jan Willem van Dalen, Lennard L Van Wanrooij, Eric P Moll van Charante, Edo Richard, Willem A van Gool
OBJECTIVE: To assess whether apathy and depressive symptoms are independently associated with incident dementia during 6-year follow-up in a prospective observational population-based cohort study. METHODS: Participants were community-dwelling older people in the Prevention of Dementia by Intensive Vascular Care trial, aged 70-78 years, without dementia at baseline. Apathy and depressive symptoms were measured using the 15-item Geriatric Depression Scale (GDS-15)...
January 2, 2018: Neurology
https://www.readbyqxmd.com/read/29169581/vitamin-d-status-is-associated-with-executive-function-a-decade-later-data-from-the-women-s-healthy-ageing-project
#9
Alicia M Goodwill, Stephen Campbell, Steven Simpson, Maria Bisignano, Cherie Chiang, Lorraine Dennerstein, Cassandra Szoeke
OBJECTIVES: Vitamin D deficiency has been associated with cognitive decline and dementia in older adults. However, there is a paucity of studies assessing whether this association manifests from midlife. Given the long prodromal stage of dementia, we investigated the association between midlife vitamin D and cognition 10 years later. STUDY DESIGN: 252 participants (aged 55-67 years) from the Women's Healthy Ageing Project had baseline (2002) vitamin D and neuropsychological measures assessed...
January 2018: Maturitas
https://www.readbyqxmd.com/read/29089345/loss-of-female-sex-hormones-exacerbates-cerebrovascular-and-cognitive-dysfunction-in-aortic-banded-miniswine-through-a-neuropeptide-y-ca2-activated-potassium-channel-nitric-oxide-mediated-mechanism
#10
T Dylan Olver, Jessica A Hiemstra, Jenna C Edwards, Todd R Schachtman, Cheryl M Heesch, Paul J Fadel, M Harold Laughlin, Craig A Emter
BACKGROUND: Postmenopausal women represent the largest cohort of patients with heart failure with preserved ejection fraction, and vascular dementia represents the most common form of dementia in patients with heart failure with preserved ejection fraction. Therefore, we tested the hypotheses that the combination of cardiac pressure overload (aortic banding [AB]) and the loss of female sex hormones (ovariectomy [OVX]) impairs cerebrovascular control and spatial memory. METHODS AND RESULTS: Female Yucatan miniswine were separated into 4 groups (n=7 per group): (1) control, (2) AB, (3) OVX, and (4) AB-OVX...
October 31, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29023080/depression-is-linked-to-dementia-in-older-adults
#11
COMMENT
Vyara Valkanova, Klaus P Ebmeier, Charlotte L Allan
Depression and dementia are both common conditions in older people, and they frequently occur together. Late life depression affects about 3.0-4.5% of adults aged 65 and older. Depression occurs in up to 20% of patients with Alzheimer’s disease and up to 45% of patients with vascular dementia. Rather than a risk factor, depression with onset in later life is more likely to be either prodromal to dementia or a condition that unmasks pre-existing cognitive impairment by compromising cognitive reserve. Depression can be a psychological response to receiving a diagnosis of dementia...
January 2017: Practitioner
https://www.readbyqxmd.com/read/28984595/low-prevalence-and-clinical-effect-of-vascular-risk-factors-in-early-onset-alzheimer-s-disease
#12
Yaohua Chen, Adeline Rollin Sillaire, Jean Dallongeville, Emilie Skrobala, David Wallon, Bruno Dubois, Didier Hannequin, Florence Pasquierthe
BACKGROUND: Determinants of early-onset Alzheimer's disease (EOAD) are not well known. In late-onset AD, vascular risk factors (VRFs) are associated with earlier clinical manifestation. OBJECTIVE: The objective of this study was to assess the putative association between VRFs and EOAD. METHODS: We studied participants with dementia meeting criteria for EOAD (recruited into the French CoMAJ prospective cohort study from 1 June 2009 to 28 February 2014) and age-, gender-matched controls (ratio 1:3, drawn randomly from the French MONA-LISA population-based survey between 2005 and 2007)...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28958051/psychosocial-pathways-to-racial-ethnic-inequalities-in-late-life-memory-trajectories
#13
Laura B Zahodne, Ketlyne Sol, Zarina Kraal
Objectives: Blacks and Hispanics are at increased risk for dementia, even after socioeconomic and vascular factors are taken into account. This study tests a comprehensive model of psychosocial pathways leading to differences in longitudinal cognitive outcomes among older blacks and Hispanics, compared to non-Hispanic whites. Methods: Using data from 10,173 participants aged 65 and older in the Health and Retirement Study, structural equation models tested associations among race/ethnicity, perceived discrimination, depressive symptoms, external locus of control, and 6-year memory trajectories, controlling for age, sex, educational attainment, income, wealth, and chronic diseases...
September 6, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28954594/subjective-memory-change-mood-and-cerebrovascular-risk-factors-in-older-african-americans
#14
Scott A Sperling, Siny Tsang, Ishan C Williams, Moon Ho Park, Ira M Helenius, Carol A Manning
OBJECTIVE: Subjective memory change (SMC) in older individuals may represent a harbinger of cognitive decline. This study examined the factors associated with SMC in older African Americans (AA), who have greater risk of developing dementia. We predicted that symptoms of depression and anxiety, as well as the total number of cerebrovascular risk factors (tCVRFs), but not performances on objective memory measures, would be positively associated with SMC. METHODS: Ninety-six AA completed brief cognitive testing and answered questions about mood and memory at their primary care appointment...
January 1, 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28936936/-treatment-of-dementia
#15
K Blom, G A H van den Elsen, H L Koek, J B Sanders, H C Kruithof, J A H R Claassen
- Treatment options for patients with dementia are limited. This article provides an overview of possible interventions, both pharmaceutical and non-pharmaceutical, for Alzheimer's disease, vascular dementia and mixed dementia.- Pharmaceutical treatment options include cholinesterase inhibitors, memantine and experimental medication. Cholinesterase inhibitors are only recommended for Alzheimer's disease and mixed dementia, not for vascular dementia or mild cognitive impairment. There is no proof of effectiveness for the other pharmaceutical options...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28923099/whole-blood-gene-expression-and-white-matter-hyperintensities
#16
Honghuang Lin, Claudia Satizabal, Zhijun Xie, Qiong Yang, Tianxiao Huan, Roby Joehanes, Chengping Wen, Peter J Munson, Alexa Beiser, Daniel Levy, Sudha Seshadri
BACKGROUND: White matter hyperintensities (WMH) are an important biomarker of cumulative vascular brain injury and have been associated with cognitive decline and an increased risk of dementia, stroke, depression, and gait impairments. The pathogenesis of white matter lesions however, remains uncertain. The characterization of gene expression profiles associated with WMH might help uncover molecular mechanisms underlying WMH. METHODS: We performed a transcriptome-wide association study of gene expression profiles with WMH in 3248 participants from the Framingham Heart Study using the Affymetrix Human Exon 1...
September 18, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28923026/dementia-and-cognitive-disorder-identified-at-a-forensic-psychiatric-examination-a-study-from-sweden
#17
Anette Ekström, Marianne Kristiansson, Karin Sparring Björkstén
BACKGROUND: Few studies have addressed the relationship between dementia and crime. We conducted a study of persons who got a primary or secondary diagnosis of dementia or cognitive disorder in a forensic psychiatric examination. METHODS: In Sweden, annually about 500 forensic psychiatric examinations are carried out. All cases from 2008 to 2010 with the diagnoses dementia or cognitive disorder were selected from the database of the Swedish National Board of Forensic Medicine...
September 18, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28919857/divergent-roles-of-vascular-burden-and-neurodegeneration-in-the-cognitive-decline-of-geriatric-depression-patients-and-mild-cognitive-impairment-patients
#18
Qing Ye, Fan Su, Liang Gong, Hao Shu, Wenxiang Liao, Chunming Xie, Hong Zhou, Zhijun Zhang, Feng Bai
Both geriatric depression and mild cognitive impairment (MCI) confer an increased risk for the development of dementia. The mechanisms underlying the development of cognitive impairment in geriatric depression patients remain controversial. The present study aimed to explore the association of cognitive decline with vascular risk, white matter hyperintensity (WMH) burden and hippocampal volume in both remitted geriatric depression (RGD) subjects and amnestic mild cognitive impairment (aMCI) subjects. Forty-one RGD subjects, 51 aMCI subjects, and 64 healthy elderly subjects underwent multimodal MRI scans and neuropsychological tests at both baseline and a 35-month follow-up...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28835407/sleep-architecture-and-the-risk-of-incident-dementia-in-the-community
#19
Matthew P Pase, Jayandra J Himali, Natalie A Grima, Alexa S Beiser, Claudia L Satizabal, Hugo J Aparicio, Robert J Thomas, Daniel J Gottlieb, Sandford H Auerbach, Sudha Seshadri
OBJECTIVE: Sleep disturbance is common in dementia, although it is unclear whether differences in sleep architecture precede dementia onset. We examined the associations between sleep architecture and the prospective risk of incident dementia in the community-based Framingham Heart Study (FHS). METHODS: Our sample comprised a subset of 321 FHS Offspring participants who participated in the Sleep Heart Health Study between 1995 and 1998 and who were aged over 60 years at the time of sleep assessment (mean age 67 ± 5 years, 50% male)...
September 19, 2017: Neurology
https://www.readbyqxmd.com/read/28828207/cerebral-gray-matter-volume-reduction-in-subcortical-vascular-mild-cognitive-impairment-patients-and-subcortical-vascular-dementia-patients-and-its-relation-with-cognitive-deficits
#20
Maoyu Li, Yao Meng, Minzhong Wang, Shuang Yang, Hui Wu, Bin Zhao, Guangbin Wang
INTRODUCTION: Subcortical vascular mild cognitive impairment (svMCI) is the predementia stage of subcortical vascular dementia (SVaD). The aim of this research is to explore and compare cerebral gray matter (GM) volume reduction in svMCI patients and SVaD patients, and to investigate the relationship between cerebral GM volume reduction and cognitive deficits. METHODS: Thirty one svMCI patients, 29 SVaD patients, and 31 healthy controls were recruited in our research...
August 2017: Brain and Behavior
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