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https://www.readbyqxmd.com/read/29245186/endothelial-dysfunction-in-early-systemic-lupus-erythematosus-patients-and-controls-without-previous-cardiovascular-events
#1
Mara Taraborelli, Edoardo Sciatti, Ivano Bonadei, Vincenzo Terlizzi, Micaela Fredi, Roberta Zani, Giovanni Cancarini, Angela Tincani, Franco Franceschini, Enrico Vizzardi, Ilaria Cavazzana
OBJECTIVES: To assess the prevalence and risk factors for endothelial dysfunction detected by peripheral artery tonometry in systemic lupus erythematosus patients with early disease without cardiovascular disease and risk factors. METHODS: All the consecutive adult lupus patients, with a disease duration less than 5 years, seen in our Hospital from December 2014 to March 2016 were considered. We excluded patients with any history of cardiovascular disease or risk factors possibly affecting peripheral artery tonometry...
December 15, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29244798/amplitude-integrated-electroencephalography-during-the-first-72-hours-after-birth-in-neonates-diagnosed-prenatally-with-congenital-heart-disease
#2
Mirthe J Mebius, Nathalie J E Oostdijk, Sara J Kuik, Arend F Bos, Rolf M F Berger, Caterina M Bilardo, Elisabeth M W Kooi, Hendrik J Ter Horst
BACKGROUND: Little is known on amplitude-integrated electroencephalography (aEEG) during the first days after birth in neonates with CHD. Our aim was, therefore, to assess electro-cortical activity using aEEG within the first 72 h after birth in neonates diagnosed prenatally with CHD, and to define independent prenatal and postnatal predictors for abnormal aEEG. METHODS: Neonates with CHD that were admitted to the neonatal intensive care unit between 2010 and 2017 were retrospectively included...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29243995/the-relationship-of-erectile-dysfunction-and-subclinical-cardiovascular-disease-a-systematic-review-and-meta-analysis
#3
Chukwuemeka U Osondu, Bryan Vo, Ebenezer T Oni, Michael J Blaha, Emir Veledar, Theodore Feldman, Arthur S Agatston, Khurram Nasir, Ehimen C Aneni
Erectile dysfunction (ED) is associated with cardiovascular disease (CVD) and CVD mortality. However, the relationship between ED and subclinical CVD is less clear. We synthesized the available data on the association of ED and measures of subclinical CVD. We searched multiple databases for published literature on studies examining the association of ED and measures of subclinical CVD across four domains: endothelial dysfunction measured by flow-mediated dilation (FMD), carotid intima-media thickness (cIMT), coronary artery calcification (CAC), and other measures of vascular function such as the ankle-brachial index, toe-brachial index, and pulse wave velocity...
December 1, 2017: Vascular Medicine
https://www.readbyqxmd.com/read/29243787/atherosclerosis-and-cardiovascular-involvement-in-celiac-disease-the-role-of-autoimmunity-and-inflammation
#4
L Santoro, G De Matteis, M Fuorlo, B Giupponi, A M Martone, F Landi, R Landolfi, A Santoliquido
OBJECTIVE: The aim of this review is to explore the evidence about the association among celiac disease (CD), atherosclerosis (AS) and cardiovascular (CV) diseases, and the role of inflammation in this connection. MATERIALS AND METHODS: A systematic literature search was conducted using PubMed, EMBASE, and Cochrane Library for the association among CD, AS and CV diseases. RESULTS: Several studies reported the association of CD with accelerated AS, as evidenced by the alterations of a number of parameters indicative of subclinical AS, as increased carotid artery intima-media thickness, endothelial dysfunction and increased arterial stiffness...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29243511/acute-stress-disorder-and-c-reactive-protein-in-patients-with-acute-myocardial-infarction
#5
Hannes Bielas, Rebecca E Meister-Langraf, Jean-Paul Schmid, Jürgen Barth, Hansjörg Znoj, Ulrich Schnyder, Mary Princip, Roland von Känel
Background Myocardial infarction-triggered acute stress disorder (ASD) and subclinical inflammation associate with the development of posttraumatic stress disorder, and worsen the prognosis of myocardial infarction patients. We examined the relationship between ASD severity and C-reactive protein levels in patients with acute myocardial infarction. Methods We assessed 190 patients (median age 59 years; 83% men) with a verified myocardial infarction within 48 h of an acute coronary intervention. Circulating levels of C-reactive protein were categorized according to their prognostic risk for cardiovascular disease: 0 to <5, 5 to <10, 10 to <20, and ≥ 20 mg/l...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29243370/neurological-nutritional-and-alcohol-consumption-factors-underlie-cognitive-and-motor-deficits-in-chronic-alcoholism
#6
Rosemary Fama, Anne-Pascale Le Berre, Cheshire Hardcastle, Stephanie A Sassoon, Adolf Pfefferbaum, Edith V Sullivan, Natalie M Zahr
Variations in pattern and extent of cognitive and motor impairment occur in alcoholism (ALC). Causes of such heterogeneity are elusive and inconsistently accounted for by demographic or alcohol consumption differences. We examined neurological and nutritional factors as possible contributors to heterogeneity in impairment. Participants with ALC (n = 96) and a normal comparison group (n = 41) were examined on six cognitive and motor domains. Signs of historically determined subclinical Wernicke's encephalopathy were detected using the Caine et al...
December 15, 2017: Addiction Biology
https://www.readbyqxmd.com/read/29243301/evaluation-of-the-live-biotherapeutic-product-asymptomatic-bacteriuria-escherichia-coli-2-12-in-healthy-dogs-and-dogs-with-clinical-recurrent-uti
#7
G Segev, J E Sykes, D J Klumpp, A J Schaeffer, E M Antaki, B A Byrne, R E Yaggie, J L Westropp
BACKGROUND: Antimicrobial resistance is an emerging problem. HYPOTHESIS/OBJECTIVE: To investigate the safety and efficacy of a live biotherapeutic product, ASB E. coli 2-12 for UTI treatment. ANIMALS: Six healthy research dogs; nine client-owned dogs with recurrent UTI. METHODS: Prospective noncontrolled clinical trial. For safety data, research dogs were sedated, a urinary catheter was inserted into the bladder; 1010 CFU/mL of ASB E...
December 15, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29243191/pharmacologically-induced-impairment-of-neurovascular-coupling-responses-alters-gait-coordination-in-mice
#8
Stefano Tarantini, Andriy Yabluchanksiy, Gábor A Fülöp, Peter Hertelendy, M Noa Valcarcel-Ares, Tamas Kiss, Jonathan M Bagwell, Daniel O'Connor, Eszter Farkas, Farzaneh Sorond, Anna Csiszar, Zoltan Ungvari
There is correlative evidence that impaired cerebral blood flow (CBF) regulation, in addition to promoting cognitive impairment, is also associated with alterations in gait and development of falls in elderly people. CBF is adjusted to neuronal activity via neurovascular coupling (NVC) and this mechanism becomes progressively impaired with age. To establish a direct cause-and-effect relationship between impaired NVC and gait abnormalities, we induced neurovascular uncoupling pharmacologically in young C57BL/6 mice by inhibiting the synthesis of vasodilator mediators involved in NVC...
December 14, 2017: GeroScience
https://www.readbyqxmd.com/read/29242418/subclinical-hypothyroidism-a-prospective-observational-study-from-southern-india
#9
Mathrubootham Sridhar, Shriraam Mahadevan, Latha Vishwanathan, Anbezhil Subbarayan
OBJECTIVE: To assess the natural history and progression of subclinical hypothyroidism and to study factors which help predict evolution of subclinical hypothyroidism into overt hypothyroidism. METHODS: Longitudinal study in 40 children (2-16 yrs) presenting with subclinical hypothyroidism in a tertiary care unit in Chennai, India. Patients showing evidence of overt hypothyroidism or thyroid stimulating hormone ≥ 15 mIU/mL during follow-up were started on thyroxine...
December 14, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/29242126/significance-of-elevated-prohibitin-1-levels-in-multiple-sclerosis-patients-lymphocytes-towards-the-assessment-of-subclinical-disease-activity-and-its-role-in-the-central-nervous-system-pathology-of-disease
#10
Satheesh Kumar M K, Sreepriya Nair, Ullas Mony, Sugavanan Kalingavarman, Ramaswamynathan Venkat, Sivanarayanan T B, Unni Akk, Ramiah Rajeshkannan, Anandakumar Anandakuttan, Sureshkumar Radhakrishnan, Krishnakumar N Menon
Multiple Sclerosis (MS) is an autoimmune-neurodegenerative disorder managed therapeutically by modulating lymphocytes activity which has potential in disease management. Prohibitin 1(PHB) that controls the reactive oxygen species (ROS) and present on the activated lymphocytes have significance in the therapy of MS as esters of fumaric acid that regulates ROS is in phase II/III clinical trials. Thus, we evaluated the expression levels of PHB1 in experimental autoimmune encephalomyelitis (EAE), the animal model of MS and on MS patient's lymphocytes...
December 11, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29241668/neutrophil-to-lymphocyte-ratio-is-a-strong-predictor-of-atherosclerotic-carotid-plaques-in-older-adults
#11
T Corriere, S Di Marca, E Cataudella, A Pulvirenti, S Alaimo, B Stancanelli, L Malatino
BACKGROUND AND AIMS: The Neutrophil-to-Lymphocyte Ratio (NLR), an index of systemic inflammation, has been reported to be associated with subclinical atherosclerosis, but its predictive role of the presence of carotid atherosclerotic plaques remains undefined. This study aims to assess this association which gives additional value to this biomarker, with respect to the main risk factors, in the prediction of carotid atherosclerosis in older adults. METHODS AND RESULTS: We recruited 324 patients, aged ≥65 years, without hematopoietic disorders, and/or history of malignancies, evidence of acute infections, chronic inflammatory status, and history of glucocorticoid therapy within the past three months, hospitalized in the Unit of Internal Medicine, University of Catania, Catania, Italy from January 2014 to December 2016...
November 5, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29241485/normal-ldl-cholesterol-levels-are-associated-with-subclinical-atherosclerosis-in-the-absence-of-risk%C3%A2-factors
#12
Leticia Fernández-Friera, Valentín Fuster, Beatriz López-Melgar, Belén Oliva, José M García-Ruiz, José Mendiguren, Héctor Bueno, Stuart Pocock, Borja Ibáñez, Antonio Fernández-Ortiz, Javier Sanz
BACKGROUND: Absence of cardiovascular risk factors (CVRFs) is traditionally considered low risk for atherosclerosis; however, individuals without CVRFs, as currently defined, still have events. OBJECTIVES: This study sought to identify predictors of subclinical atherosclerosis in CVRF-free individuals. METHODS: Participants from the PESA (Progression of Early Subclinical Atherosclerosis) study (n = 4,184) without conventional CVRFs were evaluated (n = 1,779; 45...
December 19, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29240887/associations-between-unemployment-and-heavy-episodic-drinking-from-adolescence-to-midlife-in-sweden-and-finland
#13
Noora Berg, Olli Kiviruusu, Taina Huurre, Tomi Lintonen, Pekka Virtanen, Anne Hammarström
Background: Unemployment and alcohol use have often been found to correlate and to act as risk factors for each other. However, only few studies have examined these associations at longitudinal settings extending over several life phases. Moreover, previous studies have mostly used total consumption or medical diagnoses as the indicator, whereas subclinical measures of harmful alcohol use, such as heavy episodic drinking (HED), have been used rarely. The aim of this study was to examine the associations between HED and unemployment from adolescence to midlife in two Nordic countries...
December 12, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29239461/subclinical-atherogenesis-in-patients-with-mild-psoriasis-a-role-for-il-6
#14
Michelle Larissa Zini Lise, Talita Siara Almeida Baptista, Laura Esteves Petersen, Moisés Evandro Bauer, Cláudia Almeida Lopes Ungaretti, Elton Torres, Karen Harter, Henrique Luiz Staub
INTRODUCTION: A link of psoriasis with subclinical atherosclerosis has been postulated and cytokine network might intermediate this association. Few data are available in patients with mild psoriasis. We evaluated carotid intima-media thickness (cIMT) in drug-free psoriatic individuals and controls. In parallel, we searched for associations of cIMT with disease activity indexes and serum interleukins (IL) in psoriatic patients. METHOD: An experienced radiologist performed the cIMT analyses...
September 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29239120/a-call-for-prevention-and-early-intervention-in-obsessive-compulsive-disorder
#15
REVIEW
Vlasios Brakoulias, Iain E Perkes, Emmanouil Tsalamanios
BACKGROUND: Evidence suggests that many people with obsessive-compulsive disorder (OCD) have subclinical symptoms years before the development of their disorder and that early treatment may reduce its severity. AIM: To explore prevention and early intervention strategies for OCD. METHODS: A narrative literature review was conducted. RESULTS: The literature in relation to the prevention of OCD is sparse. Genetic and environmental factors appear to be relevant to the aetiology of OCD, for example, the observation that hoarding symptoms and contamination/cleaning symptoms are more likely to also be present in first-degree relatives...
December 14, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29238323/relationship-between-hypothyroidism-and-non-alcoholic-fatty-liver-disease-a-systematic-review-and-meta-analysis
#16
Weiwei He, Xiaofei An, Ling Li, Xiaoqing Shao, Qian Li, Qiuming Yao, Jin-An Zhang
Background: Previous studies propose that hypothyroidism might play a crucial role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), but findings from published studies on the relationship between hypothyroidism and NAFLD are still controversial. Our study aimed to make a comprehensive evaluation of the relationship between hypothyroidism and NAFLD through a meta-analysis. Methods: PubMed, China Dissertation Database, and EMBASE databases were searched to find observational studies assessing the relationship between hypothyroidism and NAFLD...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29238231/adverse-maternal-outcomes-and-birth-weight-discordance-in-twin-gestation-british-columbia-canadian-data
#17
Shayesteh Jahanfar, Kenneth Lim
Objective: The aim of this study was to determine whether twin pregnancies with birth weight discordance were associated with higher rates of maternal morbidities. Study design: A large retrospective population-based cohort study of twins born in British Columbia, Canada, from 2000 to 2010 was performed. Maternal morbidities and growth discordant were evaluated. Results: There were 6,328 twin deliveries during the study period. Pregnancies carrying growth-discordant twins had higher frequencies of hypertension disorders, preterm labor, and cesarean delivery compared with growth-concordant twins...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/29238001/the-inverse-relationship-between-cardiorespiratory-fitness-and-intima-media-thickness-with-prehypertensive-middle-aged-women
#18
Dokyung Kim, Wonhah Park
Individuals with prehypertension have a greater risk of developing hypertension and cardiovascular disease than those with normal blood pressure. Good cardiorespiratory fitness has been associated with a reduced risk for cardiovascular diseases, but whether it is related to slower progression of early atherosclerosis is unclear. We evaluated 442 women, aged 40-60 years, with resting systolic blood pressure 120-139 mmHg and diastolic blood pressure 80-89 mmHg, defined as prehypertension in cross-sectional study...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29237158/dermoscopy-of-morphea-and-cutaneous-lichen-sclerosus-clinicopathological-correlation-study-and-comparative-analysis
#19
Enzo Errichetti, Aimilios Lallas, Zoe Apalla, Alessandro Di Stefani, Giuseppe Stinco
BACKGROUND: Dermoscopy of morphea and cutaneous lichen sclerosus (CLS) has been described by various studies, with none of them considering variability according to clinical phases and investigating dermoscopic-histological correlations. OBJECTIVE: To evaluate dermoscopic features in general and according to clinical stage, identify possible distinctive dermoscopic clues, and assess dermoscopy accuracy in detecting subclinical alterations in morphea and CLS. METHODS: A representative dermoscopic image of target lesions was evaluated for the presence of specific features, correlating them with clinical subtype (inflammatory, inflammatory-sclerotic, sclerotic, or sclerotic-atrophic)...
December 14, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29237149/association-of-antibodies-to-citrullinated-protein-antigens-with-blood-pressure-in-first-degree-relatives-of-rheumatoid-arthritis-patients-the-studies-of-the-etiology-of-rheumatoid-arthritis
#20
Jan M Hughes-Austin, Ryan W Gan, Kevin D Deane, Michael H Weisman, M Kristen Demoruelle, Jeremy Sokolove, William H Robinson, V Michael Holers, Jill M Norris, Joachim H Ix
BACKGROUND: Hypertension is more common in patients with rheumatoid arthritis (RA) than in the general population. It is unknown whether hypertension is due to RA-related medications or the disease itself. Therefore, we sought to investigate associations between RA-related autoantibodies, specifically antibodies to citrullinated protein antigens (ACPA) and systolic blood pressure (SBP) and diastolic blood pressure (DBP) in first-degree relatives of RA patients, who were free of RA and RA-related medications...
December 13, 2017: American Journal of Nephrology
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