keyword
MENU ▼
Read by QxMD icon Read
search

leprae

keyword
https://www.readbyqxmd.com/read/29686668/emerging-concepts-of-adaptive-immunity-in-leprosy
#1
REVIEW
Soumi Sadhu, Dipendra Kumar Mitra
Leprosy is a chronic intracellular infection caused by the acid-fast bacillus, Mycobacterium leprae . The disease chiefly affects the skin, peripheral nerves, mucosa of the upper respiratory tract, and the eyes. The damage to peripheral nerves results in sensory and motor impairment with characteristic deformities and disability. Presently, the disease remains concentrated in resource-poor countries in tropical and warm temperate regions with the largest number of cases reported from India. Even though innate immunity influences the clinical manifestation of the disease, it is the components of adaptive immune system which seem to tightly correlate with the characteristic spectrum of leprosy...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29670618/bcg-and-adverse-events-in-the-context-of-leprosy
#2
Renate Richardus, Anouk van Hooij, Susan J F van den Eeden, Louis Wilson, Korshed Alam, Jan Hendrik Richardus, Annemieke Geluk
Background: Notwithstanding its beneficial immunoprophylactic outcomes regarding leprosy and childhood TB, BCG vaccination may cause adverse events, particularly of the skin. However, this local hyper-immune reactivity cannot be predicted before vaccination, nor is its association with protection against leprosy known. In this study we investigated the occurrence of adverse events after BCG (re)vaccination in contacts of leprosy patients and analyzed whether the concomitant systemic anti-mycobacterial immunity was associated with these skin manifestations...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29669693/can-anti-pgl-1-and-anti-ndo-lid-1-antibody-titers-be-used-to-predict-the-risk-of-reactions-in-leprosy-patients
#3
Amanda Carreira Devides, Patricia Sammarco Rosa, Andréa de Faria Fernandes Belone, Neusa Maria Broch Coelho, Somei Ura, Eliane Aparecida Silva
Leprosy patients may present reactional episodes classified as type I or reversal reaction and type II or erythema nodosum leprosum. Early diagnosis of these reactions is hampered by lack of diagnostic tests. This study aimed at evaluating anti-Mycobacterium leprae antibody levels in reactional and nonreactional leprosy patients at the time of diagnosis. Clinical data and serum samples of 224 patients diagnosed between 2009 and 2010 were collected in the municipality of Rondonópolis-MTBR. Quantification of anti-phenolic glycolipid-1 (PGL-1) IgM antibodies of M...
March 16, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29666623/autoimmunity-to-tropomyosin-specific-peptides-induced-by-mycobacterium-leprae-in-leprosy-patients-identification-of-mimicking-proteins
#4
Itu Singh, Asha Ram Yadav, Keshar Kunja Mohanty, Kiran Katoch, Prashant Sharma, Vinay Kumar Pathak, Deepa Bisht, Umesh D Gupta, Utpal Sengupta
Background: It has been shown earlier that there is a rise in the levels of autoantibodies and T cell response to cytoskeletal proteins in leprosy. Our group recently demonstrated a rise in both T and B cell responses to keratin and myelin basic protein in all types of leprosy patients and their associations in type 1 reaction (T1R) group of leprosy. Objectives: In this study, we investigated the association of levels of autoantibodies and lymphoproliferation against myosin in leprosy patients across the spectrum and tried to find out the mimicking proteins or epitopes between host protein and protein/s of Mycobacterium leprae ...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29665434/differential-growth-of-mycobacterium-leprae-strains-snp-genotypes-in-armadillos
#5
Rahul Sharma, Pushpendra Singh, Maria Pena, Ramesh Subramanian, Vladmir Chouljenko, Joohyun Kim, Nayong Kim, John Caskey, Marie A Baudena, Linda B Adams, Richard W Truman
Leprosy (Hansen's Disease) has occurred throughout human history, and persists today at a low prevalence in most populations. Caused by Mycobacterium leprae, the infection primarily involves the skin, mucosa and peripheral nerves. The susceptible host range for Mycobacterium leprae is quite narrow. Besides humans, nine banded armadillos (Dasypus novemcinctus) and red squirrels (Sciurus vulgaris) are the only other natural hosts for M. leprae, but only armadillos recapitulate the disease as seen in humans. Armadillos across the Southern United States harbor a single predominant genotypic strain (SNP Type-3I) of M...
April 14, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29665029/grocott-methenamine-silver-and-periodic-acid-schiff-positivity-in-cutaneous-mycobacterium-avium-complex-infection
#6
Robert Schnietz, Morgan L Wilson
Although often used to identify fungi within granulomatous infiltrates, Grocott's methenamine silver (GMS) and periodic acid-Schiff (PAS) stains have also been reported to stain Mycobacterium leprae (1). There is limited literature concerning the results of these stains when applied to other mycobacterial species. We have recently observed prominent GMS and PAS positivity in a case of cutaneous Mycobacterium avium complex (MAC) infection.
April 17, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29643852/innate-immune-responses-in-leprosy
#7
REVIEW
Roberta Olmo Pinheiro, Veronica Schmitz, Bruno Jorge de Andrade Silva, André Alves Dias, Beatriz Junqueira de Souza, Mayara Garcia de Mattos Barbosa, Danuza de Almeida Esquenazi, Maria Cristina Vidal Pessolani, Euzenir Nunes Sarno
Leprosy is an infectious disease that may present different clinical forms depending on host immune response to Mycobacterium leprae . Several studies have clarified the role of various T cell populations in leprosy; however, recent evidences suggest that local innate immune mechanisms are key determinants in driving the disease to its different clinical manifestations. Leprosy is an ideal model to study the immunoregulatory role of innate immune molecules and its interaction with nervous system, which can affect homeostasis and contribute to the development of inflammatory episodes during the course of the disease...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29627640/genetic-variants-structural-and-functional-changes-of-myelin-protein-zero-and-mannose-binding-lectin-2-protein-involved-in-immune-response-and-its-allelic-transmission-in-families-of-patients-with-leprosy-in-colombia
#8
Viviana Cardona-Pemberthy, Michelle Rendón, Juan Camilo Beltrán, Alejandro Soto-Ospina, Amalia Muñoz-Gomez, Pedronel Araque-Marín, Mauricio Corredor, Gabriel Bedoya, Nora Cardona-Castrod
Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Genetic factors associated with immune response contribute to infection development and disease. M. leprae has the capacity to invade Schwann cells in the peripheral nervous system and cause neuropathy. However, while the responsible molecular mechanisms remain to be fully unveiled, they have begun being elucidated. We studied genetic variants Myelin Protein Zero (MPZ), a major structural component of the myelin sheath, and Mannose Binding Lectin 2 (MBL2), a protein involved in immune response, in 112 family groups of 114 leprosy patients using PCR-RFLP, aiming to calculate the association and allelic transmission of variants associated in first, second and third-degree relatives...
April 5, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29619429/-acanthamoeba-sp-s-11-phagocytotic-activity-on-mycobacterium-leprae-in-different-nutrient-conditions
#9
Sepling Paling, Ratna Wahyuni, Ni'matuzahroh, Dwi Winarni, Iswahyudi, Linda Astari, Dinar Adriaty, Indropo Agusni, Shinzo Izumi
Background: Mycobacterium leprae ( M. leprae ) is a pathogenic bacterium that causes leprosy. The presence of M. leprae in the environment is supported by microorganisms that act as the new host for M. leprae . Acanthamoeba 's potential to be a host of M. leprae in the environment. Acanthamoeba sp. is Free Living Amoeba (FLA) that classified as holozoic, saprophytic, and saprozoic. The existence of nutrients in the environment influence Acanthamoeba ability to phagocytosis or pinocytosis...
2018: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29619252/lepvax-a-defined-subunit-vaccine-that-provides-effective-pre-exposure-and-post-exposure-prophylaxis-of-m-leprae-infection
#10
Malcolm S Duthie, Maria T Pena, Gigi J Ebenezer, Thomas P Gillis, Rahul Sharma, Kelly Cunningham, Michael Polydefkis, Yumi Maeda, Masahiko Makino, Richard W Truman, Steven G Reed
Sustained elimination of leprosy as a global health concern likely requires a vaccine. The current standard, BCG, confers only partial protection and precipitates paucibacillary (PB) disease in some instances. When injected into mice with the T helper 1 (Th1)-biasing adjuvant formulation Glucopyranosyl Lipid Adjuvant in stable emulsion (GLA-SE), a cocktail of three prioritized antigens (ML2055, ML2380 and ML2028) reduced M. leprae infection levels. Recognition and protective efficacy of a single chimeric fusion protein incorporating these antigens, LEP-F1, was confirmed in similar experiments...
2018: NPJ Vaccines
https://www.readbyqxmd.com/read/29610605/a-study-of-selenium-in-leprosy
#11
Donna Partogi, Dina Arwina Dalimunthe, Cut Putri Hazlianda
INTRODUCTION: Leprosy is a chronic infection caused by Mycobacterium leprae. Selenium, on the other hand, is a substance, which is needed for its protective role against microorganism infection. AIM: This study aims to know the association between selenium serum levels with bacteriological index. METHODS: This is an analytical cross-sectional study model. Sampling was done with consecutive sampling method in Pirngadi General Hospital, Lau Simomo Leprosy Hospital and H...
March 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29609530/high-frequency-of-m-leprae-dna-detection-in-asymptomatic-household-contacts
#12
Rafael Silva Gama, Thalisson Artur Ribeiro Gomides, Chaiana Fróes Magalhães Gama, Suelen Justo Maria Moreira, Fernanda Saloum de Neves Manta, Lorena Bruna P de Oliveira, Pedro Henrique Ferreira Marçal, Euzenir Nunes Sarno, Milton Ozório Moraes, Raúl Marcel González Garcia, Lucia Alves de Oliveira Fraga
BACKGROUND: Characterization of the Mycobacterium leprae genome has made possible the development of Polymerase Chain Reaction (PCR) systems that can amplify different genomic regions. Increased reliability and technical efficiency of quantitative PCR (qPCR) makes it a promising tool for early diagnosis of leprosy. Index cases that are multibacillary spread the bacillus silently, even before they are clinically diagnosed. Early detection and treatment could prevent transmission in endemic areas...
April 2, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29605649/mast-cell-heterogeneity-and-anti-inflammatory-annexin-a1-expression-in-leprosy-skin-lesions
#13
Maurício B Costa, Kallyne K O Mimura, Aline A Freitas, Emerith M Hungria, Ana Lúcia O M Sousa, Sonia M Oliani, Mariane M A Stefani
Mast cells (MCs) have important immunoregulatory roles in skin inflammation. Annexin A1 (ANXA1) is an endogenous anti-inflammatory protein that can be expressed by mast cells, neutrophils, eosinophils, monocytes, epithelial and T cells. This study investigated MCs heterogeneity and ANXA1 expression in human dermatoses with special emphasis in leprosy. Sixty one skin biopsies from 2 groups were investigated: 40 newly diagnosed untreated leprosy patients (18 reaction-free, 11 type 1 reaction/T1R, 11 type 2 reaction/T2R); 21 patients with other dermatoses...
March 29, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29567948/structural-implications-of-mutations-conferring-rifampin-resistance-in-mycobacterium-leprae
#14
Sundeep Chaitanya Vedithi, Sony Malhotra, Madhusmita Das, Sheela Daniel, Nanda Kishore, Anuja George, Shantha Arumugam, Lakshmi Rajan, Mannam Ebenezer, David B Ascher, Eddy Arnold, Tom L Blundell
The rpoB gene encodes the β subunit of RNA polymerase holoenzyme in Mycobacterium leprae (M. leprae). Missense mutations in the rpoB gene were identified as etiological factors for rifampin resistance in leprosy. In the present study, we identified mutations corresponding to rifampin resistance in relapsed leprosy cases from three hospitals in southern India which treat leprosy patients. DNA was extracted from skin biopsies of 35 relapse/multidrug therapy non-respondent leprosy cases, and PCR was performed to amplify the 276 bp rifampin resistance-determining region of the rpoB gene...
March 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29567906/nontuberculous-mycobacterial-empyema-in-an-immunocompetent-child
#15
Ira Shah, Forum Shah
Nontuberculous mycobacterium (NTM) species are mycobacterial species other than those belonging to the Mycobacterium Tuberculosis complex and Mycobacterium leprae. There are very few reports of NTM in immunocompetent children causing empyema. In this article, we report a 9-year-old immunocompetent girl who presented with Mycobacterium avium-intracellulare empyema.
January 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29566236/is-disability-in-leprosy-still-a-burden-a-cross-sectional-study-in-a-rural-block-in-tamil-nadu-india
#16
Dinesh Kumar Ganesan, Logaraj Muthunarayanan
Background: Leprosy, a disease caused by Mycobacterium leprae, is an important cause of preventable disability. Methods: The present cross-sectional study was undertaken among leprosy-affected persons in a rural block in Kanchipuram District, Tamil Nadu, India in the year 2013. The sample included treatment completed leprosy affected persons ≥18 y of age. Persons with difficulty in cognition and those who were not willing to participate in the study were excluded...
March 16, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29565968/blood-coagulation-abnormalities-in-multibacillary-leprosy-patients
#17
Débora Santos da Silva, Lisandra Antonia Castro Teixeira, Daniela Gois Beghini, André Teixeira da Silva Ferreira, Márcia de Berredo Moreira Pinho, Patricia Sammarco Rosa, Marli Rambaldi Ribeiro, Monica Di Calafiori Freire, Mariana Andrea Hacker, José Augusto da Costa Nery, Maria Cristina Vidal Pessolani, Ana Maria Freire Tovar, Euzenir Nunes Sarno, Jonas Perales, Fernando Augusto Bozza, Danuza Esquenazi, Robson Queiroz Monteiro, Flavio Alves Lara
BACKGROUND: Leprosy is a chronic dermato-neurological disease caused by Mycobacterium leprae infection. In 2016, more than 200,000 new cases of leprosy were detected around the world, representing the most frequent cause of infectious irreversible deformities and disabilities. PRINCIPAL FINDINGS: In the present work, we demonstrate a consistent procoagulant profile on 40 reactional and non-reactional multibacillary leprosy patients. A retrospective analysis in search of signs of coagulation abnormalities among 638 leprosy patients identified 35 leprosy patients (5...
March 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29557724/drug-targeted-virtual-screening-and-molecular-dynamics-of-lipu-protein-of-mycobacterium-tuberculosis-and-mycobacterium-leprae
#18
Gurkamaljit Kaur, Bharati Pandey, Arbind Kumar, Naina Garewal, Abhinav Grover, Jagdeep Kaur
The lipolytic protein LipU was conserved in mycobacterium sp. including M. tuberculosis (MTB LipU) and M. leprae (MLP LipU). The MTB LipU was identified in extracellular fraction and was reported to be essential for the survival of mycobacterium. Therefore to address the problem of drug resistance in pathogen, LipU was selected as a drug target and the viability of finding out some FDA approved drugs as LipU inhibitors in both the cases was explored. Three dimensional (3D) model structures of MTB LipU and MLP LipU were generated and stabilized through molecular dynamics (MD)...
March 20, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29545426/coinfection-of-leprosy-and-tuberculosis
#19
Seema Shetty, Shashikiran Umakanth, Bhawani Manandhar, Pankaj Bahadur Nepali
Leprosy and tuberculosis (TB) are endemic to India, however, their coinfection is not frequently encountered in clinical practice. Here, we report a 32-year-old female patient who presented with a history of high-grade intermittent fever, cough and painless skin lesions since a month, along with bilateral claw hand (on examination). The haematological profile was suggestive of anaemia of chronic disease, chest radiograph showed consolidation, sputum smears were positive for Mycobacterium tuberculosis, and skin slit smear confirmed leprosy...
March 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29536982/resistance-to-anti-leprosy-drugs-in-multi-bacillary-leprosy-a-cross-sectional-study-from-a-tertiary-care-centre-in-eastern-uttar-pradesh-india
#20
Satyendra Kumar Singh, Ajit Kumar, Gopal Nath, Tej Bali Singh, Mukti Nath Mishra
BACKGROUND: WHO MDT is the main drug regimen for treating leprosy and has been used for more than three decades. Many cases of relapse of leprosy have been reported, which points towards the emergence of drug resistance with the antileprotic drugs. OBJECTIVES: To find the resistance with the antileprotic drugs by detecting the mutations in drug resistance determining region of the rpoB, folP1 and gyrA genes of Mycobacterium leprae. METHODS: Leprosy patients with bacterial index ≥2 were included in the study...
March 14, 2018: Indian Journal of Dermatology, Venereology and Leprology
keyword
keyword
89331
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"