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JOURNAL ARTICLE
Monica Christin Hansen, Lisbeth Uhrenfeldt, Kari Ingstad, Preben U Pedersen
BACKGROUND: Disease-related malnutrition after a hospital stay has major consequences for older adults, the healthcare system and society. This study aims to develop and test the effectiveness of an educational video to prevent loss of health-related quality of life among live-at-home older adults after surgical treatment in a hospital. METHOD: This randomised controlled trial will occur at a regional hospital in Norway. Participants will be live-at-home adults aged 65 years and older...
April 15, 2024: Trials
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JOURNAL ARTICLE
Bjørk K Sofíudóttir, Stefan Harders, Christian B Laursen, Philip R Lage-Hansen, Sabrina M Nielsen, Søren A Just, Robin Christensen, Jesper R Davidsen, Torkell Ellingsen
OBJECTIVE: The Objective was to determine the diagnostic accuracy of thoracic ultrasound (TUS) for detecting (ILD) in rheumatoid arthritis (RA) with respiratory symptoms. METHODS: Individuals with RA visiting Rheumatological outpatient clinics in the Region of Southern Denmark were systematically screened for dyspnoea, cough, recurrent pneumonia, prior severe pneumonia or a chest X-ray indicating interstitial abnormalities. Eighty participants with a positive screening were consecutively included...
April 15, 2024: Arthritis Care & Research
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Yongqun Oliver He, Laura Barisoni, Avi Z Rosenberg, Peter Robinson, Alexander D Diehl, Yichao Chen, Jimmy P Phuong, Jens Hansen, Bruce W Herr, Katy Börner, Jennifer Schaub, Nikki Bonevich, Ghida Arnous, Saketh Boddapati, Jie Zheng, Fadhl Alakwaa, Pinaki Sarder, William D Duncan, Chen Liang, M Todd Valerius, Sanjay Jain, Ravi Iyengar, Jonathan Himmelfarb, Matthias Kretzler
Many data resources generate, process, store, or provide kidney related molecular, pathological, and clinical data. Reference ontologies offer an opportunity to support knowledge and data integration. The Kidney Precision Medicine Project (KPMP) team contributed to the representation and addition of 329 kidney phenotype terms to the Human Phenotype Ontology (HPO), and identified many subcategories of acute kidney injury (AKI) or chronic kidney disease (CKD). The Kidney Tissue Atlas Ontology (KTAO) imports and integrates kidney-related terms from existing ontologies (e...
April 2, 2024: bioRxiv
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Sergio Gil Rodríguez, Priya Crosby, Louise L Hansen, Ellen Grünewald, Andrew D Beale, Rebecca K Spangler, Beverley M Rabbitts, Carrie L Partch, Alessandra Stangherlin, John S O'Neill, Gerben van Ooijen
Circadian (∼24 h) rhythms are a fundamental feature of life, and their disruption increases the risk of infectious diseases, metabolic disorders, and cancer 1-6 . Circadian rhythms couple to the cell cycle across eukaryotes 7,8 but the underlying mechanism is unknown. We previously identified an evolutionarily conserved circadian oscillation in intracellular potassium concentration, [K + ] i 9,10 . As critical events in the cell cycle are regulated by intracellular potassium 11,12 , an enticing hypothesis is that circadian rhythms in [K + ] i form the basis of this coupling...
April 3, 2024: bioRxiv
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JOURNAL ARTICLE
Lasse Kronborg, Emma Oxlund Hansen, Trine Bertelsen, Anne Hald Rittig, Thomas Emmanuel, Sofie Jørgensen, Kasper Fjellhaugen Hjuler, Lars Iversen, Claus Johansen
BACKGROUND: Interleukin-17A (IL-17A) is a proinflammatory cytokine, playing an essential role in the development of psoriasis. Although treatment with anti-IL-17A monoclonal antibodies has demonstrated high efficacy in psoriasis patients, not all patients respond equally well, highlighting the need for biomarkers to predict treatment response. Specific single nucleotide polymorphisms (SNPs) in the endoplasmatic reticulum aminopeptidase (ERAP) 1 and 2 genes have been associated with psoriasis and other immune-mediated diseases...
April 15, 2024: Clinical and Experimental Dermatology
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JOURNAL ARTICLE
Vaishali Vinod, Karolina Saegner, Walter Maetzler, Elke Warmerdam, Robbin Romijnders, Thorben Beyer, Robert Göder, Clint Hansen, Klarissa Stürner
BACKGROUND: Multiple Sclerosis (MS) is a chronic inflammatory autoimmune, neurodegenerative disease that affects regular mobility and leads predominantly to physical disability. Poor sleep quality, commonly reported in MS patients, impacts their physical activity (PA). Accelerometers monitor 24-h activity patterns, offering insights into disease progression in daily life. OBJECTIVE: To test if the sleep quality variables of MS patients, as assessed with wrist-worn accelerometers, differ from those of controls and are associated with PA and disease severity variables...
March 22, 2024: Sleep Medicine
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JOURNAL ARTICLE
Stephen Hebard, GracieLee Weaver, William B Hansen, Scarlett Ruppert
BACKGROUND: Overprescription of opioids has led to increased misuse of opioids, resulting in higher rates of overdose. The workplace can play a vital role in an individual's intentions to misuse prescription opioids with injured workers being prescribed opioids, at a rate 3 times the national average. For example, health care workers are at risk for injuries, opioid dispensing, and diversion. Intervening within a context that may contribute to risks for opioid misuse while targeting individual psychosocial factors may be a useful complement to interventions at policy and prescribing levels...
April 12, 2024: JMIR Formative Research
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JOURNAL ARTICLE
Astrid Baumann Olesen, Sabine Michelsen Raunbak, Rikke Bækkely Sass Mathiesen, Marie Dam Lauridsen, Nikolaj Brix Hansen, Ulla Møller Weinreich
Telemedicine is emerging and has both clinical, scientific, and political interest. In this review, we present the present literature on implementation and describe the economic considerations when implementing telemedicine in chronic obstructive pulmonary disease (COPD). The use of telemedicine in COPD is well-received by patients, but there is little evidence to suggest its superiority to standard outpatient care or to support better outcomes for patients. Thus, local settings and cost effectiveness should be considered during the implementational process...
April 1, 2024: Ugeskrift for Laeger
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Shweta B Hembrom, Ghazal Ahmed, Habib Md R Karim, Vineeta Singh, Priyanka Rai, Suchita V Meshram
Leprosy is known for its diverse pathophysiologic involvement and resulting multisystemic manifestation and morbidities. Despite global efforts to eliminate this public health illness, it is still prevalent in some Asian and European countries. Perioperative management of a leprosy patient is challenging owing to the indirect and direct involvement of the airway, respiratory, and cardiac systems; treatment-related side-effects involving the hepato-renal systems affecting the anesthesia techniques and drugs pharmacokinetic and pharmacodynamics...
March 2024: Curēus
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JOURNAL ARTICLE
Silja Hansen Haldrup, Bjørn K Fabian-Jessing, Thomas Stax Jakobsen, Anna Bøgh Lindholm, Rikke L Adsersen, Lars Aagaard, Toke Bek, Anne Louise Askou, Thomas J Corydon
Neovascular age-related macular degeneration (nAMD) is a frequent cause of vision loss among the elderly in the Western world. Current disease management with repeated injections of anti-VEGF agents accumulates the risk for adverse events and constitutes a burden for society and the individual patient. Sustained suppression of VEGF using gene therapy is an attractive alternative, which we explored using adeno-associated virus (AAV)-based delivery of novel RNA interference (RNAi) effectors in a porcine model of choroidal neovascularization (CNV)...
June 13, 2024: Molecular Therapy. Methods & Clinical Development
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JOURNAL ARTICLE
Marwan H Othman, Markus Harboe Olsen, Karen Irgens Tanderup Hansen, Moshgan Amiri, Helene Ravnholt Jensen, Benjamin Nyholm, Kirsten Møller, Jesper Kjaergaard, Daniel Kondziella
BACKGROUND: Identifying covert consciousness in intensive care unit (ICU) patients with coma and other disorders of consciousness (DoC) is crucial for treatment decisions, but sensitive low-cost bedside markers are missing. We investigated whether automated pupillometry combined with passive and active cognitive paradigms can detect residual consciousness in ICU patients with DoC. METHODS: We prospectively enrolled clinically low-response or unresponsive patients with traumatic or nontraumatic DoC from ICUs of a tertiary referral center...
April 11, 2024: Neurocritical Care
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JOURNAL ARTICLE
Viktor Rotbain Curovic, Brede A Sørland, Tine W Hansen, Siddhi Y Jain, Karolina Sulek, Ismo Matias Mattila, Marie Frimodt-Moller, Kajetan Trost, Cristina Legido-Quigley, Simone Theilade, Nete Tofte, Signe Abitz Winther, Christian Stevns Hansen, Peter Rossing, Tarunveer S Ahluwalia
INTRODUCTION: Diabetic retinopathy (DR), diabetic kidney disease (DKD) and distal symmetric polyneuropathy (DSPN) share common pathophysiology and pose an additive risk of early mortality. RESEARCH DESIGN AND METHODS: In adults with type 1 diabetes, 49 metabolites previously associated with either DR or DKD were assessed in relation to presence of DSPN. Metabolites overlapping in significance with presence of all three complications were assessed in relation to microvascular burden severity (additive number of complications-ie, presence of DKD±DR±DSPN) using linear regression models...
April 11, 2024: BMJ Open Diabetes Research & Care
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JOURNAL ARTICLE
Susanna Klevebro, Simon Kebede Merid, Ulrika Sjöbom, Wen Zhong, Hanna Danielsson, Dirk Wackernagel, Ingrid Hansen-Pupp, David Ley, Karin Sävman, Mathias Uhlén, Lois E H Smith, Ann Hellström, Anders K Nilsson
BACKGROUND & AIM: Clinical trials supplementing the long-chain polyunsaturated fatty acids (LCPUFAs) docosahexaenoic acid (DHA) and arachidonic acid (AA) to preterm infants have shown positive effects on inflammation-related morbidities, but the molecular mechanisms underlying these effects are not fully elucidated. This study aimed to determine associations between DHA, AA, and inflammation-related proteins during the neonatal period in extremely preterm infants. METHODS: A retrospective exploratory study of infants (n = 183) born below 28 weeks gestation from the Mega Donna Mega trial, a randomized multicenter trial designed to study the effect of DHA and AA on retinopathy of prematurity...
April 3, 2024: Clinical Nutrition
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JOURNAL ARTICLE
John R de Almeida, Rosemary Martino, Ali Hosni, David P Goldstein, Scott V Bratman, Douglas B Chepeha, John N Waldron, Ilan Weinreb, Bayardo Perez-Ordonez, Eugene Yu, Ur Metser, Aaron R Hansen, Wei Xu, Susie Jie Su, John Kim
IMPORTANCE: Patients with unknown primary squamous cell carcinoma (CUP) with cervical metastases typically receive comprehensive radiotherapy (RT) of the pharynx and bilateral neck. Typically, these patients receive comprehensive RT of the pharynx and bilateral neck that may produce treatment-related toxic effects. OBJECTIVE: To determine whether localization of occult oropharyngeal cancers with transoral robotic surgery (TORS) combined with reduced pharyngeal and neck RT volumes provides acceptable disease control...
April 11, 2024: JAMA Otolaryngology—Head & Neck Surgery
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JOURNAL ARTICLE
Stéphanie Pascual, Brooklyn Noble, Nusreen Ahmad-Saeed, Catherine Aldridge, Simone Ambretti, Sharon Amit, Rachel Annett, Shaan Ashk O'Shea, Anna Maria Barbui, Gavin Barlow, Lucinda Barrett, Mario Berth, Alessandro Bondi, Nicola Boran, Sara E Boyd, Catarina Chaves, Martin Clauss, Peter Davies, Ileana T Dianzo-Delgado, Jaime Esteban, Stefan Fuchs, Lennart Friis-Hansen, Daniel Goldenberger, Andrej Golle, Juha O Groonroos, Ines Hoffmann, Tomer Hoffmann, Harriet Hughes, Marina Ivanova, Peter Jezek, Gwennan Jones, Zeynep Ceren Karahan, Cornelia Lass-Flörl, Frédéric Laurent, Laura Leach, Matilde Lee Horsbøll Pedersen, Caroline Loiez, Maureen Lynch, Robert J Maloney, Martin Marsh, Olivia Milburn, Shanine Mitchell, Luke S P Moore, Lynn Moffat, Marianna Murdjeva, Michael E Murphy, Deepa Nayar, Giacomo Nigrisoli, Fionnuala O'Sullivan, Büşra Öz, Teresa Peach, Christina Petridou, Mojgan Prinz, Mitja Rak, Niamh Reidy, Gian Maria Rossolini, Anne-Laure Roux, Patricia Ruiz-Garbajosa, Kordo Saeed, Llanos Salar-Vidal, Carlos Salas Venero, Mathyruban Selvaratnam, Eric Senneville, Peter Starzengruber, Ben Talbot, Vanessa Taylor, Rihard Trebše, Deborah Wearmouth, Birgit Willinger, Marjan Wouthuyzen-Bakker, Brianne Couturier, Florence Allantaz
Introduction : The BIOFIRE Joint Infection (JI) Panel is a diagnostic tool that uses multiplex-PCR testing to detect microorganisms in synovial fluid specimens from patients suspected of having septic arthritis (SA) on native joints or prosthetic joint infections (PJIs). Methods : A study was conducted across 34 clinical sites in 19 European and Middle Eastern countries from March 2021 to June 2022 to assess the effectiveness of the BIOFIRE JI Panel. Results : A total of 1527 samples were collected from patients suspected of SA or PJI, with an overall agreement of 88...
2024: Journal of Bone and Joint Infection
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Maria Barington, Mads Bak, Kristín Rós Kjartansdóttir, Thomas van Overeem Hansen, Ulf Birkedal, Elsebet Østergaard, Hanne Buciek Hove
Alu elements are short, interspersed elements located throughout the genome, playing a role in human diversity, and occasionally causing genetic diseases. Here, we report a novel Alu insertion causing Mowat-Wilson syndrome, a rare neurodevelopmental disorder, in an 8-year-old boy displaying the typical clinical features for Mowat-Wilson syndrome. The variant was not initially detected in genome sequencing data, but through deep phenotyping, which pointed to only one plausible candidate gene, manual inspection of genome sequencing alignment data enabled us to identify a de novo heterozygous Alu insertion in exon 8 of the ZEB2 gene...
April 11, 2024: American Journal of Medical Genetics. Part A
#37
JOURNAL ARTICLE
Ganna Isayeva, Klara Rumora, Eliska Potlukova, Jan-Philipp Leibfarth, Ibrahim Schäfer, Zsofia Bartha, Michael J Zellweger, Marten Trendelenburg, Trine Korsgaard Hejlesen, Annette Gudmann Hansen, Steffen Thiel, Christian Mueller
BACKGROUND: This study aimed to evaluate the diagnostic and prognostic potential of MAp19, a regulating component of the lectin pathway of the complement system, in patients with suspected functionally relevant coronary artery disease (fCAD) as well as the determinants of MAp19 levels. METHODS: The presence of fCAD was adjudicated using myocardial perfusion imaging with single-photon emission tomography and, where available, coronary angiography. MAp19 levels were measured in participants at rest, at peak stress tests, and two hours after the stress...
April 8, 2024: Clinica Chimica Acta; International Journal of Clinical Chemistry
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JOURNAL ARTICLE
Daniel T Hansen, Nicole J Rueb, Nathan D Levinzon, Thomas E Cheatham, Robert Gaston, Kh Tanvir Ahmed, Sandra Osburn-Staker, James E Cox, Gregory B Dudley, Amy M Barrios
Leukocyte antigen-related (LAR) phosphatase is a receptor-type protein tyrosine phosphatase involved in cellular signaling and associated with human disease including cancer and metabolic disorders. Selective inhibition of LAR phosphatase activity by well characterized and well validated small molecules would provide key insights into the roles of LAR phosphatase in health and disease, but identifying selective inhibitors of LAR phosphatase activity has been challenging. Recently, we described potent and selective inhibition of LAR phosphatase activity by the fungal natural product illudalic acid...
April 8, 2024: Bioorganic & Medicinal Chemistry Letters
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JOURNAL ARTICLE
Casper S Poulsen, Dan Hesse, Gabriel R Fernandes, Tue H Hansen, Timo Kern, Allan Linneberg, Lore Van Espen, Torben Jørgensen, Trine Nielsen, Amra C Alibegovic, Jelle Matthijnssens, Oluf Pedersen, Henrik Vestergaard, Torben Hansen, Mette K Andersen
Latent autoimmune diabetes in adults (LADA) is a heterogeneous disease characterized by autoantibodies against insulin producing pancreatic beta cells and initial lack of need for insulin treatment. The aim of the present study was to investigate if individuals with LADA have an altered gut microbiota relative to non-diabetic control subjects, individuals with type 1 diabetes (T1D), and individuals with type 2 diabetes (T2D). Bacterial community profiling was performed with primers targeting the variable region 4 of the 16S rRNA gene and sequenced...
April 9, 2024: Scientific Reports
#40
JOURNAL ARTICLE
Quinn A Hoorn, Maria B Rabaglino, Thiago F Amaral, Tatiane S Maia, Fahong Yu, John B Cole, Peter J Hansen
The objective was to identify a set of genes whose transcript abundance is predictive of a cow's ability to become pregnant following artificial insemination (AI). Endometrial epithelial cells from the uterine body were collected for RNA sequencing using the cytobrush method from 193 first-service Holstein cows at estrus prior to AI (day 0). A group of 253 first-service cows not used for cytobrush collection were controls. There was no effect of cytobrush collection on pregnancy outcomes at day 30 or 70 or on pregnancy loss between day 30 and 70...
April 9, 2024: Biology of Reproduction
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