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https://www.readbyqxmd.com/read/27909080/ankylosing-spondylitis-versus-nonradiographic-axial-spondyloarthritis-comparison-of-tumor-necrosis-factor-inhibitor-effectiveness-and-effect-of-hla-b27-status-an-observational-cohort-study-from-the-nationwide-danbio-registry
#1
Bente Glintborg, Inge J Sørensen, Mikkel Østergaard, Lene Dreyer, Abdiweli A Mohamoud, Niels S Krogh, Oliver Hendricks, Lis S Andersen, Johnny L Raun, Marcin R Kowalski, Laura Danielsen, Randi Pelck, Henrik Nordin, Jens K Pedersen, Dorte G A Kraus, Susan R Christensen, Inger M J Hansen, Jakob Esbesen, Annette Schlemmer, Anne G Loft, Nabil Al Chaer, Lone Salomonsen, Merete L Hetland
OBJECTIVE: To compare baseline disease activity and treatment effectiveness in biologic-naive patients with nonradiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) who initiate tumor necrosis factor inhibitor (TNFi) treatment and to study the role of potential confounders (e.g., HLA-B27 status). METHODS: Observational cohort study based on prospectively registered data in the nationwide DANBIO registry. We used Kaplan-Meier plots, Cox, and logistic regression analyses to study the effect of diagnosis (nr-axSpA vs AS) and potential confounders (sex/age/start yr/HLA-B27/disease duration/TNFi-type/smoking/baseline disease activity) on TNFi adherence and response [e...
December 1, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27908689/pcsk9-genetic-variants-and-risk-of-type-2-diabetes-a-mendelian-randomisation-study
#2
Amand F Schmidt, Daniel I Swerdlow, Michael V Holmes, Riyaz S Patel, Zammy Fairhurst-Hunter, Donald M Lyall, Fernando Pires Hartwig, Bernardo Lessa Horta, Elina Hyppönen, Christine Power, Max Moldovan, Erik van Iperen, G Kees Hovingh, Ilja Demuth, Kristina Norman, Elisabeth Steinhagen-Thiessen, Juri Demuth, Lars Bertram, Tian Liu, Stefan Coassin, Johann Willeit, Stefan Kiechl, Karin Willeit, Dan Mason, John Wright, Richard Morris, Goya Wanamethee, Peter Whincup, Yoav Ben-Shlomo, Stela McLachlan, Jackie F Price, Mika Kivimaki, Catherine Welch, Adelaida Sanchez-Galvez, Pedro Marques-Vidal, Andrew Nicolaides, Andrie G Panayiotou, N Charlotte Onland-Moret, Yvonne T van der Schouw, Giuseppe Matullo, Giovanni Fiorito, Simonetta Guarrera, Carlotta Sacerdote, Nicholas J Wareham, Claudia Langenberg, Robert Scott, Jian'an Luan, Martin Bobak, Sofia Malyutina, Andrzej Pająk, Ruzena Kubinova, Abdonas Tamosiunas, Hynek Pikhart, Lise Lotte Nystrup Husemoen, Niels Grarup, Oluf Pedersen, Torben Hansen, Allan Linneberg, Kenneth Starup Simonsen, Jackie Cooper, Steve E Humphries, Murray Brilliant, Terrie Kitchner, Hakon Hakonarson, David S Carrell, Catherine A McCarty, H Lester Kirchner, Eric B Larson, David R Crosslin, Mariza de Andrade, Dan M Roden, Joshua C Denny, Cara Carty, Stephen Hancock, John Attia, Elizabeth Holliday, Martin O' Donnell, Salim Yusuf, Michael Chong, Guillaume Pare, Pim van der Harst, M Abdullah Said, Ruben N Eppinga, Niek Verweij, Harold Snieder, Tim Christen, Dennis O Mook-Kanamori, Stefan Gustafsson, Lars Lind, Erik Ingelsson, Raha Pazoki, Oscar Franco, Albert Hofman, Andre Uitterlinden, Abbas Dehghan, Alexander Teumer, Sebastian Baumeister, Marcus Dörr, Markus M Lerch, Uwe Völker, Henry Völzke, Joey Ward, Jill P Pell, Daniel J Smith, Tom Meade, Anke H Maitland-van der Zee, Ekaterina V Baranova, Robin Young, Ian Ford, Archie Campbell, Sandosh Padmanabhan, Michiel L Bots, Diederick E Grobbee, Philippe Froguel, Dorothée Thuillier, Beverley Balkau, Amélie Bonnefond, Bertrand Cariou, Melissa Smart, Yanchun Bao, Meena Kumari, Anubha Mahajan, Paul M Ridker, Daniel I Chasman, Alex P Reiner, Leslie A Lange, Marylyn D Ritchie, Folkert W Asselbergs, Juan-Pablo Casas, Brendan J Keating, David Preiss, Aroon D Hingorani, Naveed Sattar
BACKGROUND: Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest hyperglycaemia, increased bodyweight, and modestly increased risk of type 2 diabetes, which in no way offsets their substantial benefits. We sought to investigate the associations of LDL cholesterol-lowering PCSK9 variants with type 2 diabetes and related biomarkers to gauge the likely effects of PCSK9 inhibitors on diabetes risk...
November 28, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27899944/epidemiology-and-genetics-of-ventricular-fibrillation-during-acute-myocardial-infarction
#3
REVIEW
Charlotte Glinge, Stefan Sattler, Reza Jabbari, Jacob Tfelt-Hansen
Sudden cardiac death (SCD) from ventricular fibrillation (VF) during coronary artery disease (CAD) is a leading cause of total and cardiovascular mortality, and in more than half of SCD cases VF occurs as the first symptom of CAD. Several epidemiological studies have shown that sudden death of a family member is a risk factor for SCD and VF during acute myocardial infarction (MI), independent of traditional risk factors including family history of MI, suggesting a genetic component in the susceptibility to VF...
September 2016: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/27891436/platelet-rich-plasma-efficacy-in-treating-trophic-ulcers-in-leprosy
#4
V Anandan, W Afthab Jameela, P Saraswathy, S Sarankumar
INTRODUCTION: Trophic ulcers secondary to leprosy pose a great stigma to the patients and remain a challenge to the treating dermatologists. The discovery of Platelet Rich Plasma (PRP) with its favourable role in wound healing is a boon for the patients. PRP introduces the growth factors directly into the wound and aids in rapid healing. AIM: To study the efficacy and safety of PRP in the healing of trophic ulcers secondary to Hansen's disease in a tertiary care centre in Southern India...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27890936/increased-proportion-of-mature-nk-cells-is-associated-with-successful-imatinib-discontinuation-in-chronic-myeloid-leukemia
#5
M Ilander, U Olsson-Strömberg, H Schlums, J Guilhot, O Brück, H Lähteenmäki, T Kasanen, P Koskenvesa, S Söderlund, M Höglund, B Markevärn, A Själander, K Lotfi, A Dreimane, A Lübking, E Holm, M Björeman, S Lehmann, L Stenke, L Ohm, T Gedde-Dahl, W Majeed, H Ehrencrona, S Koskela, S Saussele, F-X Mahon, K Porkka, H Hjorth-Hansen, Y T Bryceson, J Richter, S Mustjoki
Recent studies suggest that a proportion of chronic myeloid leukemia (CML) patients in deep molecular remission can discontinue the tyrosine kinase inhibitor (TKI) treatment without disease relapse. In this multi-center, prospective clinical trial (EURO-SKI, NCT01596114) we analyzed the function and phenotype of T and NK cells and their relation to successful TKI cessation. Lymphocyte subclasses were measured from 100 imatinib treated patients at baseline and 1 month after the discontinuation, and functional characterization of NK and T cells was done from 45 patients...
November 28, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27886386/costs-of-perennial-allergic-rhinitis-and-allergic-asthma-increase-with-severity-and-poor-disease-control
#6
Manon Belhassen, Pascal Demoly, Evelyne Bloch-Morot, Gérard de Pouvourville, Marine Ginoux, Antoine Chartier, Laurent Laforest, Niels Serup-Hansen, Massoud Toussi, Eric Van Ganse
BACKGROUND: Perennial allergic rhinitis (PAR) represents a global and public health problem, due to its prevalence, morbidity, and impact on the quality of life. PAR is frequently associated to allergic asthma (AA). Costs of PAR with or without AA are poorly documented. OBJECTIVE: Our study aimed to detail medical resource utilization (MRU) and related direct cost for PAR, with or without concomitant AA, in France. METHODS: Using Electronic Health Records (EHRs), we identified in 2010 two cohorts of PAR patients, based on General Practitioners' diagnoses and prescribing data, with and without concomitant AA...
November 25, 2016: Allergy
https://www.readbyqxmd.com/read/27883970/association-between-dengue-fever-incidence-and-meteorological-factors-in-guangzhou-china-2005-2014
#7
Jianjun Xiang, Alana Hansen, Qiyong Liu, Xiaobo Liu, Michael Xiaoliang Tong, Yehuan Sun, Scott Cameron, Scott Hanson-Easey, Gil-Soo Han, Craig Williams, Philip Weinstein, Peng Bi
This study aims to (1) investigate the associations between climatic factors and dengue; and (2) identify the susceptible subgroups. De-identified daily dengue cases in Guangzhou for 2005-2014 were obtained from the Chinese Center for Disease Control and Prevention. Weather data were downloaded from the China Meteorological Data Sharing Service System. Distributed lag non-linear models (DLNM) were used to graphically demonstrate the three-dimensional temperature-dengue association. Generalised estimating equation models (GEE) with piecewise linear spline functions were used to quantify the temperature-dengue associations...
November 22, 2016: Environmental Research
https://www.readbyqxmd.com/read/27876616/protocol-for-three-parallel-multi-site-stepped-care-effectiveness-studies-for-unhealthy-alcohol-use-in-hiv-positive-patients
#8
E Jennifer Edelman, Stephen A Maisto, Nathan B Hansen, Christopher J Cutter, James Dziura, Lynn E Fiellin, Patrick G O'Connor, Roger Bedimo, Cynthia Gibert, Vincent C Marconi, David Rimland, Maria C Rodriguez-Barradas, Michael S Simberkoff, Amy C Justice, Kendall J Bryant, David A Fiellin
Unhealthy alcohol use is common among HIV-positive patients, yet effective evidence-based treatments are rarely provided in clinical settings providing HIV care. Further, given patient variability in response to initial treatments, stepped care approaches may be beneficial. We describe the rationale, aims and study design for the current StartingTreatment forEthanol inPrimary care Trials (STEP Trials); three parallel randomized controlled effectiveness trials being conducted in five Infectious Disease Clinics...
November 20, 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27872059/genome-wide-minor-histocompatibility-matching-as-related-to-the-risk-of-graft-versus-host-disease
#9
Paul J Martin, David M Levine, Barry E Storer, Edus H Warren, Xiuwen Zheng, Sarah C Nelson, Anajane G Smith, Bo K Mortensen, John A Hansen
The risk of acute graft-versus-host disease is higher after allogeneic hematopoietic cell transplantation (HCT) from unrelated donors as compared to related donors. This difference has been explained by increased recipient mismatching for major histocompatibility antigens or minor histocompatibility antigens. In the current study, we used genome-wide arrays to enumerate single nucleotide polymorphisms that produce graft-versus-host (GVH) amino acid coding differences between recipients and donors. We then tested the hypothesis that higher degrees of genome-wide recipient GVH mismatching correlate with higher risks of graft-versus-host disease (GVHD) after allogeneic HCT...
November 21, 2016: Blood
https://www.readbyqxmd.com/read/27870973/transthoracic-doppler-echocardiography-compared-with-positron-emission-tomography-for-assessment-of-coronary-microvascular-dysfunction-the-ipower-study
#10
Marie Mide Michelsen, Naja Dam Mygind, Adam Pena, Rasmus Huan Olsen, Thomas Emil Christensen, Adam Ali Ghotbi, Philip Hasbak, Andreas Kjaer, Ida Gustafsson, Peter Riis Hansen, Henrik Steen Hansen, Nis Høst, Jens Kastrup, Eva Prescott
BACKGROUND: Coronary microvascular function can be assessed by transthoracic Doppler echocardiography as a coronary flow velocity reserve (TTDE CFVR) and by positron emission tomography as a myocardial blood flow reserve (PET MBFR). PET MBFR is regarded the noninvasive reference standard for measuring coronary microvascular function but has limited availability. We compared TTDE CFVR with PET MBFR in women with angina pectoris and no obstructive coronary artery disease and assessed repeatability of TTDE CFVR...
November 7, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27870649/the-reliability-of-disease-activity-score-in-28-joints-c-reactive-protein-might-be-overestimated-in-a-subgroup-of-rheumatoid-arthritis-patients-when-the-score-is-solely-based-on-subjective-parameters-a-cross-sectional-exploratory-study
#11
Inger Marie Jensen Hansen, Rikke Asmussen Andreasen, Mark Nam van Bui Hansen, Amir Emamifar
BACKGROUND: Disease Activity Score in 28 Joints (DAS28) is a scoring system to evaluate disease activity and treatment response in rheumatoid arthritis (RA). A DAS28 score of greater than 3.2 is a well-described limit for treatment intensification; however, the reliability of DAS28 might be overestimated. OBJECTIVE: The aim of this study was to evaluate the reliability of DAS28 in RA, especially focusing on a subgroup of patients with a DAS28 score of greater than 3...
November 19, 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27869797/the-receptor-for-advanced-glycation-end-products-impairs-collateral-formation-in-both-diabetic-and-non-diabetic-mice
#12
Laura M Hansen, Divya Gupta, Giji Joseph, Daiana Weiss, W Robert Taylor
Diabetics often have poor perfusion in their limbs as a result of peripheral artery disease and an impaired ability to generate collateral vessels. The receptor for advanced glycation end products (RAGE) is one protein that is thought to play a detrimental role in collateral development in diabetics due to increased levels of advanced glycation end products (AGE), one of its ligands, in diabetes. Thus, the aim of this study was to investigate the role of RAGE in both diabetic and non-diabetic settings in a model of collateral formation in mice...
November 21, 2016: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/27864895/the-postreperfusion-syndrome-is-associated-with-acute-kidney-injury-following-donation-after-brain-death-liver-transplantation
#13
Marit Kalisvaart, Jubi E de Haan, Dennis A Hesselink, Wojciech G Polak, Bettina E Hansen, Jan N M IJzermans, Diederik Gommers, Herold J Metselaar, Jeroen de Jonge
Acute kidney injury (AKI) is frequently observed after DBD liver transplantation (LT) and associated with impaired recipient survival and chronic kidney disease. Hepatic ischemia/reperfusion injury (IRI) is suggested to be an important factor in this process. The postreperfusion syndrome (PRS) is the first manifestation of severe hepatic IRI directly after reperfusion. We performed a retrospective study on the relation between hepatic IRI and PRS and their impact on AKI in 155 DBD LT recipients. Severity of hepatic IRI was measured by peak postoperative AST levels and PRS was defined as >30% decrease in MAP ≥1 minute <5 minutes after reperfusion...
November 19, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27856511/extracellular-vesicles-released-from-chronic-lymphocytic-leukemia-cells-exhibit-a-disease-relevant-mrna-signature-and-transfer-mrnas-to-bystander-cells
#14
Katrin S Reiners, Olga Shatnyeva, Elena Vasyutina, Teresa Bösl, Hinrich P Hansen, Michael Hallek, Marco Herling, Elke Pogge von Strandmann
No abstract text is available yet for this article.
November 17, 2016: Haematologica
https://www.readbyqxmd.com/read/27855663/pre-pregnancy-community-based-intervention-for-couples-in-malaysia-application-of-intervention-mapping
#15
Shane A Norris, Julius Cheah Chee Ho, Aswir Abd Rashed, Vibeke Vinding, Jutta K H Skau, Regien Biesma, Jens Aagaard-Hansen, Mark Hanson, Priya Matzen
BACKGROUND: Malaysia is experiencing a nutrition transition with burgeoning obesity, particularly in women, and a growing prevalence of non-communicable disease. These health burdens have severe implications not only for adult health but also across generations. Pre-conception health promotion could address the intergenerational risk of metabolic disease. This paper describes the development of the "Jom Mama" intervention using Intervention Mapping (IM). The Jom Mama intervention aims to improve the health of young adult couples in Malaysia prior to conception...
November 17, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27846491/going-global-by-adapting-local-a-review-of-recent-human-adaptation
#16
REVIEW
Shaohua Fan, Matthew E B Hansen, Yancy Lo, Sarah A Tishkoff
The spread of modern humans across the globe has led to genetic adaptations to diverse local environments. Recent developments in genomic technologies, statistical analyses, and expanded sampled populations have led to improved identification and fine-mapping of genetic variants associated with adaptations to regional living conditions and dietary practices. Ongoing efforts in sequencing genomes of indigenous populations, accompanied by the growing availability of "-omics" and ancient DNA data, promises a new era in our understanding of recent human evolution and the origins of variable traits and disease risks...
October 7, 2016: Science
https://www.readbyqxmd.com/read/27835971/the-use-of-cam-providers-and-psychiatric-outpatient-services-in-people-with-anxiety-depression-a-cross-sectional-survey
#17
Anne Helen Hansen, Agnete E Kristoffersen
BACKGROUND: Depression has been identified as one of the most frequent predictors of CAM use. However, limited data exist about the use of CAM providers among people with anxiety/depression in Norway. The aim of this study was to investigate the use of CAM providers, and the use of CAM providers and psychiatric outpatient services in combination, among people with self-reported anxiety and/or depression. METHODS: We used questionnaire data from 12,982 participants (30-87 years) in the cross-sectional sixth Tromsø Study (conducted in 2007-8)...
November 11, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27834178/the-danish-national-database-for-asthma-establishing-clinical-quality-indicators
#18
REVIEW
Susanne Hansen, Benjamin Hoffmann-Petersen, Asger Sverrild, Elvira V Bräuner, Jesper Lykkegaard, Uffe Bodtger, Lone Agertoft, Lene Korshøj, Vibeke Backer
Asthma is one of the most common chronic diseases worldwide affecting more than 300 million people. Symptoms are often non-specific and include coughing, wheezing, chest tightness, and shortness of breath. Asthma may be highly variable within the same individual over time. Although asthma results in death only in extreme cases, the disease is associated with significant morbidity, reduced quality of life, increased absenteeism, and large costs for society. Asthma can be diagnosed based on report of characteristic symptoms and/or the use of several different diagnostic tests...
2016: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27832006/reconstruction-outcomes-following-lateral-skull-base-resection
#19
Nicholas J Thompson, Joseph P Roche, Nathan M Schularick, Kristi E Chang, Marlan R Hansen
OBJECTIVE: Compare reconstruction outcomes for various lateral skull base closure techniques. STUDY DESIGN: Retrospective medical records review. SETTING: University-based tertiary referral center. PATIENTS: Patients who underwent resections of tumors involving the lateral skull base requiring reconstruction beyond primary closure. INTERVENTION(S): Reconstructive techniques, from rotational flaps to free tissue transfer...
November 9, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27831499/association-of-traditional-cardiovascular-risk-factors-with-venous-thromboembolism-an-individual-participant-data-meta-analysis-of-prospective-studies
#20
Bakhtawar K Mahmoodi, Mary Cushman, Inger Anne Næss, Matthew A Allison, Willem Jan Bos, Sigrid K Brækkan, Suzanne Cannegieter, Ron T Gansevoort, Philimon N Gona, Jens Hammerstrøm, John-Bjarne Hansen, Susan Heckbert, Anders G Holst, Susan G Lakoski, Pamela L Lutsey, JoAnn E Manson, Lisa W Martin, Kunihiro Matsushita, Karina Meijer, Kim Overvad, Eva B Prescott, Marja K Puurunen, Jacques Rossouw, Yingying Sang, Marianne T Severinsen, Jur M Ten Berg, Aaron R Folsom, Neil A Zakai
BACKGROUND: -There is much controversy surrounding the association of traditional cardiovascular disease (CVD) risk factors with venous thromboembolism (VTE). METHODS: - We performed an individual level random-effect meta-analysis including 9 prospective studies with measured baseline CVD risk factors and validated VTE events. Definitions were harmonized across studies. Traditional CVD risk factors were modeled categorically, as well as continuously using restricted cubic splines...
November 9, 2016: Circulation
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