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https://www.readbyqxmd.com/read/28938014/intestinal-helminth-infection-drives-carcinogenesis-in-colitis-associated-colon-cancer
#1
Eva Pastille, Annika Frede, Henry J McSorley, Jessica Gräb, Alexandra Adamczyk, Sebastian Kollenda, Wiebke Hansen, Matthias Epple, Jan Buer, Rick M Maizels, Robert Klopfleisch, Astrid M Westendorf
Inflammatory bowel diseases (IBD) are chronic inflammatory disorders of the gastrointestinal tract, strongly associated with an increased risk of colorectal cancer development. Parasitic infections caused by helminths have been shown to modulate the host's immune response by releasing immunomodulatory molecules and inducing regulatory T cells (Tregs). This immunosuppressive state provoked in the host has been considered as a novel and promising approach to treat IBD patients and alleviate acute intestinal inflammation...
September 22, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28935000/effect-of-early-life-gut-mucosal-compromise-on-disease-progression-in-nod-mice
#2
Katja M Bendtsen, Camilla Hf Hansen, Lukasz Krych, Karsten Buschard, Helene Farlov, Axel K Hansen
Disease expression in spontaneous nonobese diabetic (NOD) mice depends on environmental stimuli such as stress, diet, and gut microbiota composition. We evaluated a brief, early-life gut intervention in which pups were weaned to low-dose dextran sulfate sodium (DSS). We hypothesized that the mucus-reducing effect of this compound and subsequent increased host-bacterial contact would delay disease onset and decrease insulitis due to enhanced oral tolerance. However, disease incidence did not differ between groups, although median survival (time point when 50% of the mice are still alive) of the control group was 184 d compared with 205 d for DSS-treated mice...
October 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28928711/validation-of-a-step-detection-algorithm-during-straight-walking-and-turning-in-patients-with-parkinson-s-disease-and-older-adults-using-an-inertial-measurement-unit-at-the-lower-back
#3
Minh H Pham, Morad Elshehabi, Linda Haertner, Silvia Del Din, Karin Srulijes, Tanja Heger, Matthis Synofzik, Markus A Hobert, Gert S Faber, Clint Hansen, Dina Salkovic, Joaquim J Ferreira, Daniela Berg, Álvaro Sanchez-Ferro, Jaap H van Dieën, Clemens Becker, Lynn Rochester, Gerhard Schmidt, Walter Maetzler
INTRODUCTION: Inertial measurement units (IMUs) positioned on various body locations allow detailed gait analysis even under unconstrained conditions. From a medical perspective, the assessment of vulnerable populations is of particular relevance, especially in the daily-life environment. Gait analysis algorithms need thorough validation, as many chronic diseases show specific and even unique gait patterns. The aim of this study was therefore to validate an acceleration-based step detection algorithm for patients with Parkinson's disease (PD) and older adults in both a lab-based and home-like environment...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28928380/predictors-of-responses-to-immune-checkpoint-blockade-in-advanced-melanoma
#4
N Jacquelot, M P Roberti, D P Enot, S Rusakiewicz, N Ternès, S Jegou, D M Woods, A L Sodré, M Hansen, Y Meirow, M Sade-Feldman, A Burra, S S Kwek, C Flament, M Messaoudene, C P M Duong, L Chen, B S Kwon, A C Anderson, V K Kuchroo, B Weide, F Aubin, C Borg, S Dalle, O Beatrix, M Ayyoub, B Balme, G Tomasic, A M Di Giacomo, M Maio, D Schadendorf, I Melero, B Dréno, A Khammari, R Dummer, M Levesque, Y Koguchi, L Fong, M Lotem, M Baniyash, H Schmidt, I M Svane, G Kroemer, A Marabelle, S Michiels, A Cavalcanti, M J Smyth, J S Weber, A M Eggermont, L Zitvogel
Immune checkpoint blockers (ICB) have become pivotal therapies in the clinical armamentarium against metastatic melanoma (MMel). Given the frequency of immune related adverse events and increasing use of ICB, predictors of response to CTLA-4 and/or PD-1 blockade represent unmet clinical needs. Using a systems biology-based approach to an assessment of 779 paired blood and tumor markers in 37 stage III MMel patients, we analyzed association between blood immune parameters and the functional immune reactivity of tumor-infiltrating cells after ex vivo exposure to ICB...
September 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28927503/learning-induces-the-translin-trax-rnase-complex-to-express-activin-receptors-for-persistent-memory
#5
Alan Jung Park, Robbert Havekes, Xiuping Fu, Rolf Hansen, Jennifer C Tudor, Lucia Peixoto, Zhi Li, Yen-Ching Wu, Shane G Poplawski, Jay M Baraban, Ted Abel
Long-lasting forms of synaptic plasticity and memory require de novo protein synthesis. Yet, how learning triggers this process to form memory is unclear. Translin/trax is a candidate to drive this learning-induced memory mechanism by suppressing microRNA-mediated translational silencing at activated synapses. We find that mice lacking translin/trax display defects in synaptic tagging, which requires protein synthesis at activated synapses, and long-term memory. Hippocampal samples harvested from these mice following learning show increases in several disease-related microRNAs targeting the activin A receptor type 1C (ACVR1C), a component of the transforming growth factor-β receptor superfamily...
September 20, 2017: ELife
https://www.readbyqxmd.com/read/28923495/crispr-cas9-engineering-of-adult-mouse-liver-demonstrates-that-the-dnajb1-prkaca-gene-fusion-is-sufficient-to-induce-tumors-resembling-fibrolamellar-hepatocellular-carcinoma
#6
Lars H Engelholm, Anjum Riaz, Denise Serra, Frederik Dagnæs-Hansen, Jens V Johansen, Eric Santoni-Rugiu, Steen H Hansen, Francesco Niola, Morten Frödin
BACKGROUND & AIMS: Fibrolamellar hepatocellular carcinoma (FL-HCC) is a primary liver cancer that predominantly affects young adults with no underlying liver disease. A somatic, 400 Kb deletion on chromosome 19 that fuses part of the DnaJ heat shock protein family (Hsp40) member B1 gene (DNAJB1) to the protein kinase cAMP-activated catalytic subunit alpha gene (PRKACA) has been repeatedly identified in patients with FL-HCC. However, the DNAJB1-PRKACA gene fusion has not been shown to induce liver tumorigenesis...
September 15, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28915867/the-associations-between-workplace-bullying-salivary-cortisol-and-long-term-sickness-absence-a-longitudinal-study
#7
Matias Brødsgaard Grynderup, Kirsten Nabe-Nielsen, Theis Lange, Paul Maurice Conway, Jens Peter Bonde, Anne Helene Garde, Maria Gullander, Linda Kaerlev, Roger Persson, Reiner Rugulies, Marianne Agergaard Vammen, Annie Høgh, Åse Marie Hansen
BACKGROUND: Workplace stressors, such as bullying, are strongly related to subsequent long-term sickness absence, but little is known of the possible physiological mechanisms linking workplace stressors and sickness absence. The primary aim of this study was to investigate to what extent cortisol levels were associated with subsequent sickness absence and if cortisol mediated the association between workplace bullying and sickness absence. We additionally investigated possible bidirectional associations between bullying, cortisol, and long-term sickness absence...
September 16, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28913977/the-effect-of-diet-or-exercise-on-ectopic-adiposity-in-children-and-adolescents-with-obesity-a-systematic-review-and-meta-analysis
#8
REVIEW
W Hens, D Vissers, D Hansen, S Peeters, J Gielen, L Van Gaal, J Taeymans
OBJECTIVE: Ectopic fat depostion in youth with obesity is associated with an increased cardiovascular disease risk. The aim of this meta-analysis was to summarize the evidence for the use of diet and/or exercise on ectopic adiposity in this population. METHODS: A systematic literature search was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis statement. Clinical trials that assessed ectopic fat deposition and included study arms with diet and/or exercise were searched in PubMed, PEDro and the Cochrane database...
September 14, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28904702/-leprosy-in-children-in-the-region-of-thi%C3%A3-s-senegal-study-determining-whether-or-not-it-is-a-signal-of-recrudescence
#9
Pauline Dioussé, Haby Dione, Mariama Bammo, Ndiaga Gueye, Thierno Abdoul Aziz Diallo, Fatou Seck, Ramatoulaye Diagne Gueye, Mame Thierno Dieng, Fatma Sarr Fall, Moustapha Diop, Bernard Marcel Diop, Mamadou Mourtalla Ka
Leprosy is an infectious and transmissible disease. According to the WHO, the number of new cases of leprosy in children in Senegal has risen moderately since 2013. This study aimed to analyze the epidemiological, clinical, therapeutic and evolutionary features of leprosy in children in the geographical areas of two social rehabilitation villages in the region of Thiès. We conducted a retrospective study over a period of 3 years (2013-2015). All new cases of Hansen's disease aged 0 -15 years were included...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28899356/barriers-to-lifestyle-changes-for-prevention-of-cardiovascular-disease-a-survey-among-40-60-year-old-danes
#10
Jesper Bo Nielsen, Anja Leppin, Dort E Gyrd-Hansen, Dorte Ejg Jarbøl, Jens Søndergaard, Pia Veldt Larsen
BACKGROUND: Elimination of modifiable risk factors including unhealthy lifestyle has the potential for prevention of 80% of cardiovascular disease cases. The present study focuses on disclosing barriers for maintaining specific lifestyle changes by exploring associations between perceiving these barriers and various sociodemographic and health-related characteristics. METHODS: Data were collected through a web-based questionnaire survey and included 962 respondents who initially accepted treatment for a hypothetical cardiovascular risk, and who subsequently stated that they preferred lifestyle changes to medication...
September 12, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28898379/effect-of-axillary-dissection-vs-no-axillary-dissection-on-10-year-overall-survival-among-women-with-invasive-breast-cancer-and-sentinel-node-metastasis-the-acosog-z0011-alliance-randomized-clinical-trial
#11
RANDOMIZED CONTROLLED TRIAL
Armando E Giuliano, Karla V Ballman, Linda McCall, Peter D Beitsch, Meghan B Brennan, Pond R Kelemen, David W Ollila, Nora M Hansen, Pat W Whitworth, Peter W Blumencranz, A Marilyn Leitch, Sukamal Saha, Kelly K Hunt, Monica Morrow
Importance: The results of the American College of Surgeons Oncology Group Z0011 (ACOSOG Z0011) trial were first reported in 2005 with a median follow-up of 6.3 years. Longer follow-up was necessary because the majority of the patients had estrogen receptor-positive tumors that may recur later in the disease course (the ACOSOG is now part of the Alliance for Clinical Trials in Oncology). Objective: To determine whether the 10-year overall survival of patients with sentinel lymph node metastases treated with breast-conserving therapy and sentinel lymph node dissection (SLND) alone without axillary lymph node dissection (ALND) is noninferior to that of women treated with axillary dissection...
September 12, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28886202/fuchs-endothelial-corneal-dystrophy-and-rna-foci-in-patients-with-myotonic-dystrophy
#12
V Vinod Mootha, Brock Hansen, Ziye Rong, Pradeep P Mammen, Zhengyang Zhou, Chao Xing, Xin Gong
Purpose: The most common cause of Fuchs' endothelial corneal dystrophy (FECD) is an intronic CTG repeat expansion in TCF4. Expanded CUG repeat RNA colocalize with splicing factor, muscleblind-like 1 (MBNL1), in nuclear foci in endothelium as a molecular hallmark. Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder caused by a CTG repeat expansion in the 3'-untranslated region (UTR) of DMPK. In this study, we examine for RNA-MBNL1 foci in endothelial cells of FECD subjects with DM1, test the hypothesis that DM1 patients are at risk for FECD, and determine prevalence of TCF4 and DMPK expansions in a FECD cohort...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28883079/folate-dietary-insufficiency-and-folic-acid-supplementation-similarly-impair-metabolism-and-compromise-hematopoiesis
#13
Curtis J Henry, Travis Nemkov, Matias Casas-Selves, Ganna Bilousova, Vadym Zaberezhnyy, Kelly C Higa, Natalie J Serkova, Krik C Hansen, Angelo D' Alessandro, James DeGregori
While dietary folate deficiency is associated with increased risk for birth defects and other diseases, evidence suggests that supplementation with folic acid can contribute to predisposition to some diseases, including immune dysfunction and cancer. Here we show that diets supplemented with folic acid both below and above the recommended levels led to significantly altered metabolism in multiple tissues in mice. Surprisingly, both low and excessive dietary folate induced similar metabolic changes, which were particularly evident for nucleotide biosynthetic pathways in B-progenitor cells...
September 7, 2017: Haematologica
https://www.readbyqxmd.com/read/28881081/a-genetically-inducible-porcine-model-of-intestinal-cancer
#14
Morten Møbjerg Callesen, Sigrid Salling Árnadóttir, Iben Lyskjaer, Mai-Britt Worm Ørntoft, Søren Høyer, Frederik Dagnaes-Hansen, Ying Liu, Rong Li, Henrik Callesen, Mads Heilskov Rasmussen, Martin Fogtmann Berthelsen, Martin Kristian Thomsen, Pawel Jan Schweiger, Kim Bak Jensen, Søren Laurberg, Torben Falck Ørntoft, Jannik Ejnar Elverløv-Jakobsen, Claus Lindbjerg Andersen
Transgenic porcine cancer models bring novel possibilities for research. Their physical similarities with humans enable the use of surgical procedures and treatment approaches used for patients, which facilitates clinical translation. Here, we aimed to develop an inducible oncopig model of intestinal cancer. Transgenic (TG) minipigs were generated using somatic cell nuclear transfer by hand-made cloning. The pigs encode two TG cassettes: 1) An Flp-recombinase inducible oncogene cassette containing KRAS-G12D, cMYC, SV40LT - which inhibits p53 - and pRB...
September 7, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28879146/trends-in-leprosy-case-detection-in-rwanda-1995-2011-analysis-of-17-years-of-laboratory-data
#15
Innocent Uwimana, Nestor Bizimungu, Fabrice Ingabire, Elyse Mukamukwiye, Odette Sharangabo, Semuto C Ngabonziza, Elaine Kamanzi
BACKGROUND: Leprosy, or Hansen's disease, is a chronic, infectious disease caused by Mycobacterium leprae. It remains one of the leading causes of deformity and physical disability. OBJECTIVE: We analysed laboratory records to assess trends in prevalence rates and case detection rates (CDRs) in Rwanda. METHODS: A retrospective review of detected leprosy cases from the records of the Rwanda National Reference Laboratory over a 17-year period (1995-2011) was conducted...
2017: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/28877717/cardiovascular-health-effects-following-exposure-of-human-volunteers-during-fire-extinction-exercises
#16
Maria Helena Guerra Andersen, Anne Thoustrup Saber, Peter Bøgh Pedersen, Steffen Loft, Åse Marie Hansen, Ismo Kalevi Koponen, Julie Elbæk Pedersen, Niels Ebbehøj, Eva-Carina Nørskov, Per Axel Clausen, Anne Helene Garde, Ulla Vogel, Peter Møller
BACKGROUND: Firefighters have increased risk of cardiovascular disease and of sudden death from coronary heart disease on duty while suppressing fires. This study investigated the effect of firefighting activities, using appropriate personal protective equipment (PPE), on biomarkers of cardiovascular effects in young conscripts training to become firefighters. METHODS: Healthy conscripts (n = 43) who participated in a rescue educational course for firefighting were enrolled in the study...
September 6, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28874241/infant-botulism-in-denmark-from-1995-to-2015
#17
Bergitte Drivenes, Tyra Grove Krause, Mikael Andersson, Luise Müller, Kurt Fuursted, Tanja Pedersen, Anne Kirkeby Hansen, Malene Landbo Børresen
INTRODUCTION: Infant botulism is a rare, probably underdiagnosed, life-threatening disease caused by the toxin-producing bacterium Clostridium botulinum. METHODS: We investigated reported cases of infant botulism in Denmark from 1995 to 2015, and compared the incidence with that of other western countries. RESULTS: We found nine cases of infant botulism in Denmark from 1995 to 2015. The incidence of infant botulism in Denmark was similar to that seen in other western countries, but likely underestimated...
September 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28874197/environmental-drivers-of-ixodes-ricinus-abundance-in-forest-fragments-of-rural-european-landscapes
#18
Steffen Ehrmann, Jaan Liira, Stefanie Gärtner, Karin Hansen, Jörg Brunet, Sara A O Cousins, Marc Deconchat, Guillaume Decocq, Pieter De Frenne, Pallieter De Smedt, Martin Diekmann, Emilie Gallet-Moron, Annette Kolb, Jonathan Lenoir, Jessica Lindgren, Tobias Naaf, Taavi Paal, Alicia Valdés, Kris Verheyen, Monika Wulf, Michael Scherer-Lorenzen
BACKGROUND: The castor bean tick (Ixodes ricinus) transmits infectious diseases such as Lyme borreliosis, which constitutes an important ecosystem disservice. Despite many local studies, a comprehensive understanding of the key drivers of tick abundance at the continental scale is still lacking. We analyze a large set of environmental factors as potential drivers of I. ricinus abundance. Our multi-scale study was carried out in deciduous forest fragments dispersed within two contrasting rural landscapes of eight regions, along a macroclimatic gradient stretching from southern France to central Sweden and Estonia...
September 6, 2017: BMC Ecology
https://www.readbyqxmd.com/read/28874164/radiation-free-cmr-diagnostic-heart-catheterization-in-children
#19
Kanishka Ratnayaka, Joshua P Kanter, Anthony Z Faranesh, Elena K Grant, Laura J Olivieri, Russell R Cross, Ileen F Cronin, Karin S Hamann, Adrienne E Campbell-Washburn, Kendall J O'Brien, Toby Rogers, Michael S Hansen, Robert J Lederman
BACKGROUND: Children with heart disease may require repeated X-Ray cardiac catheterization procedures, are more radiosensitive, and more likely to survive to experience oncologic risks of medical radiation. Cardiovascular magnetic resonance (CMR) is radiation-free and offers information about structure, function, and perfusion but not hemodynamics. We intend to perform complete radiation-free diagnostic right heart catheterization entirely using CMR fluoroscopy guidance in an unselected cohort of pediatric patients; we report the feasibility and safety...
September 6, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28870564/evaluation-of-polymerase-chain-reaction-in-nerve-biopsy-specimens-of-patients-with-hansen-s-disease
#20
Vandana Tiwari, Kiranpreet Malhotra, Kainat Khan, Pradeep K Maurya, Ajai Kumar Singh, Anup Kumar Thacker, Nuzhat Husain, Dinkar Kulshreshtha
BACKGROUND: Pure neuritic variety of leprosy (PNL) presents as peripheral neuropathy with absent skin lesions and negative skin smears. Diagnosing PNL is an uphill task as most of these patients have nonspecific changes on nerve biopsy. In such circumstances, additional molecular diagnostic tools like polymerase chain reaction (PCR) has proven to be useful in diagnosing leprosy. The present study was planned to evaluate the role of PCR in nerve biopsy specimens of patients with PNL. METHODS: Patients attending the neuromuscular clinic from January 2013 to June 2014 with mononeuropathy multiplex underwent detailed diagnostic evaluation to ascertain the cause of neuropathy...
September 15, 2017: Journal of the Neurological Sciences
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