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https://www.readbyqxmd.com/read/28094291/differential-effects-of-vitamins-a-and-d-on-the-transcriptional-landscape-of-human-monocytes-during-infection
#1
Tilman E Klassert, Julia Bräuer, Martin Hölzer, Magdalena Stock, Konstantin Riege, Cristina Zubiría-Barrera, Mario M Müller, Silke Rummler, Christine Skerka, Manja Marz, Hortense Slevogt
Vitamin A and vitamin D are essential nutrients with a wide range of pleiotropic effects in humans. Beyond their well-documented roles in cellular differentiation, embryogenesis, tissue maintenance and bone/calcium homeostasis, both vitamins have attracted considerable attention due to their association with-immunological traits. Nevertheless, our knowledge of their immunomodulatory potential during infection is restricted to single gene-centric studies, which do not reflect the complexity of immune processes...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28074234/-biological-downsizing-acetabular-defect-reconstruction-in-revision-total-hip-arthroplasty
#2
S Koob, S Scheidt, T M Randau, M Gathen, M D Wimmer, D C Wirtz, S Gravius
BACKGROUND: Periacetabular bony defects remain a great challenge in revision total hip arthroplasty. After assessment and classification of the defect and selection of a suitable implant the primary stable fixation and sufficient biological reconstitution of a sustainable bone stock are essential for long term success in acetabular revision surgery. Biological defect reconstruction aims for the down-sizing of periacetabular defects for later revision surgeries. TECHNIQUE: In the field of biological augmentation several methods are currently available...
January 10, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28042115/reconstruction-of-non-contained-acetabular-defects-with-impaction-grafting-a-reinforcement-mesh-and-a-cemented-polyethylene-acetabular-component
#3
B S Waddell, A Gonzalez Della Valle
This review summarises the technique of impaction grafting with mesh augmentation for the treatment of uncontained acetabular defects in revision hip arthroplasty. The ideal acetabular revision should restore bone stock, use a small socket in the near-anatomic position, and provide durable fixation. Impaction bone grafting, which has been in use for over 40 years, offers the ability to achieve these goals in uncontained defects. The precepts of modern, revision impaction grafting are that the segmental or cavitary defects must be supported with a mesh; the contained cavity is filled with vigorously impacted morselised fresh-frozen allograft; and finally, acrylic cement is used to stabilise the graft and provide rigid, long-lasting fixation of the revised acetabular component...
January 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28024662/quantifying-the-competing-relationship-between-adduction-range-of-motion-and-baseplate-micromotion-with-lateralization-of-reverse-total-shoulder-arthroplasty
#4
Josie Elwell, Joseph Choi, Ryan Willing
Lateralizing the center of rotation (COR) of reverse total shoulder arthroplasty (rTSA) could improve functional outcomes and mitigate scapular notching, a commonly occurring complication of the procedure. However, resulting increases in torque at the bone-implant interface may negatively affect initial fixation of the glenoid-side component, especially if only two fixation screws can be placed. Shoulder-specific finite element (FE) models of four fresh-frozen cadaveric shoulders were constructed. Scapular geometry and material property distributions were derived from CT data...
November 29, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/28008262/kinetics-of-circulating-endothelial-progenitor-cells-in-patients-undergoing-carotid-artery-surgery
#5
Günay Kalender, Angela Kornberger, Milan Lisy, Andres Beiras-Fernandez, Ulrich A Stock
AIM: Endothelial progenitor cells (EPCs) are primitive cells found in the bone marrow and peripheral blood (PB). In particular, the potential of EPCs to differentiate into mature endothelial cells remains of high interest for clinical applications such as bio-functionalized patches for autologous seeding after implantation. The objective of this study was to determine EPCs' kinetics in patients undergoing carotid artery thromboendarterectomy (CTEA) and patch angioplasty. METHODS: Twenty CTEA patients were included (15 male, mean age 76 years)...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28006107/classification-and-analysis-of-attritional-glenoid-bone-loss-in-recurrent-anterior-shoulder-instability
#6
John W McNeil, Brendin R Beaulieu-Jones, Andrew S Bernhardson, Lance E LeClere, Christopher B Dewing, Joseph R Lynch, Petar Golijanin, George Sanchez, Matthew T Provencher
BACKGROUND: Recognition and proper treatment of glenoid bone loss (GBL) are important for successful management of anterior shoulder instability. Although GBL has been described as the amount of bony loss from the front of the glenoid, there is also a fragment of bone that is usually displaced and often undergoes attrition. Thus, due to attritional bone loss (ABL) of the fragment, insufficient bone is left to fully reconstruct the glenoid. PURPOSE: To (1) evaluate ABL of the glenoid fragment in recurrent anterior shoulder instability and (2) correlate ABL with clinical history, fragment size, and radiographic findings...
December 1, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27993496/no-difference-in-periprosthetic-bone-loss-and-fixation-between-a-standard-length-stem-and-a-shorter-version-in-cementless-total-hip-arthroplasty-a-randomized-controlled-trial
#7
Jörg Schilcher, Ingemar Ivarsson, Rico Perlbach, Lars Palm
BACKGROUND: Cementless femoral stems in total hip arthroplasty provide dependable clinical and radiographic results in the treatment of osteoarthritis. Stem length might affect the preservation of proximal bone stock and stability. We hypothesized that a shorter stem decreases proximal bone loss without affecting implant stability. METHODS: We randomly assigned 60 patients aged between 50 and 70 years to either a standard cementless femoral stem or a 35-mm shorter version...
November 17, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27979378/simple-additive-manufacturing-of-an-osteoconductive-ceramic-using-suspension-melt-extrusion
#8
Casper Slots, Martin Bonde Jensen, Nicholas Ditzel, Martin A B Hedegaard, Søren Wiatr Borg, Ole Albrektsen, Torben Thygesen, Moustapha Kassem, Morten Østergaard Andersen
OBJECTIVE: Craniofacial bone trauma is a leading reason for surgery at most hospitals. Large pieces of destroyed or resected bone are often replaced with non-resorbable and stock implants, and these are associated with a variety of problems. This paper explores the use of a novel fatty acid/calcium phosphate suspension melt for simple additive manufacturing of ceramic tricalcium phosphate implants. METHODS: A wide variety of non-aqueous liquids were tested to determine the formulation of a storable 3D printable tricalcium phosphate suspension ink, and only fatty acid-based inks were found to work...
December 12, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27959731/tp53-and-decitabine-in-acute-myeloid-leukemia-and-myelodysplastic-syndromes
#9
John S Welch, Allegra A Petti, Christopher A Miller, Catrina C Fronick, Michelle O'Laughlin, Robert S Fulton, Richard K Wilson, Jack D Baty, Eric J Duncavage, Bevan Tandon, Yi-Shan Lee, Lukas D Wartman, Geoffrey L Uy, Armin Ghobadi, Michael H Tomasson, Iskra Pusic, Rizwan Romee, Todd A Fehniger, Keith E Stockerl-Goldstein, Ravi Vij, Stephen T Oh, Camille N Abboud, Amanda F Cashen, Mark A Schroeder, Meagan A Jacoby, Sharon E Heath, Kierstin Luber, Megan R Janke, Andrew Hantel, Niloufer Khan, Madina J Sukhanova, Randall W Knoebel, Wendy Stock, Timothy A Graubert, Matthew J Walter, Peter Westervelt, Daniel C Link, John F DiPersio, Timothy J Ley
Background The molecular determinants of clinical responses to decitabine therapy in patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) are unclear. Methods We enrolled 84 adult patients with AML or MDS in a single-institution trial of decitabine to identify somatic mutations and their relationships to clinical responses. Decitabine was administered at a dose of 20 mg per square meter of body-surface area per day for 10 consecutive days in monthly cycles. We performed enhanced exome or gene-panel sequencing in 67 of these patients and serial sequencing at multiple time points to evaluate patterns of mutation clearance in 54 patients...
November 24, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27955655/short-to-long-term-follow-up-of-total-femoral-replacement-in-non-oncologic-patients
#10
Andreas Toepfer, Norbert Harrasser, Isabel Petzschner, Florian Pohlig, Ulrich Lenze, Ludger Gerdesmeyer, Dominik Pförringer, Marcel Toepfer, Marc Beirer, Moritz Crönlein, Ruediger von Eisenhart-Rothe, Heinz Mühlhofer
BACKGROUND: Compromised bone stock and heavily impaired structural integrity after multiple endoprosthetic revision surgeries can lead to a comparable condition as encountered in musculoskeletal tumor surgery. Total femoral replacement (TFR) can restore femoral integrity and allow patients to resume ambulation. Even though several authors reported their results of TFR, so far many questions are still on debate: Which patients are at risk to experience low functional outcome? Do complications and clinical outcome after TFR depend on the indication for the surgery (e...
December 12, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27909661/the-oblique-mattress-lasso-loop-stitch-for-arthroscopic-capsulolabral-repair
#11
Nata Parnes, Maryellen Blevins, Monica Morman, Paul Carey
Arthroscopic capsulolabral repair during shoulder stabilization surgery requires the use of suture anchors. Several arthroscopic suturing techniques for capsulolabral repair have been described, and each carries very specific advantages and disadvantages with regard to risk, patient satisfaction, and functional outcomes. The purpose of this report is to describe the oblique mattress lasso-loop stitch. This stitch (1) provides strong initial fixation of the labrum, (2) establishes labral height and allows for larger capsular plication if needed, (3) prevents the suture from cutting through the radial fibers of the glenoid labrum, (4) prevents knot migration to the articular side and loosening of the knot, and (5) requires fewer implants and preserves glenoid bone stock by increasing the amount of labrum and capsule that can be reattached to the glenoid with a single-loaded suture anchor...
October 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/27900336/optimal-lateral-row-anchor-positioning-in-posterior-superior-transosseous-equivalent-rotator-cuff-repair-a-micro-computed-tomography-study
#12
Matthias A Zumstein, Sumit Raniga, Agatha Labrinidis, Kevin Eng, Gregory I Bain, Beat K Moor
BACKGROUND: The optimal placement of suture anchors in transosseous-equivalent (TOE) double-row rotator cuff repair remains controversial. PURPOSE: A 3-dimensional (3D) high-resolution micro-computed tomography (micro-CT) histomorphometric analysis of cadaveric proximal humeral greater tuberosities (GTs) was performed to guide optimal positioning of lateral row anchors in posterior-superior (infraspinatus and supraspinatus) TOE rotator cuff repair. STUDY DESIGN: Descriptive laboratory study...
November 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/27886360/high-proximal-migration-in-cemented-acetabular-revisions-operated-with-bone-impaction-grafting-47-revision-cups-followed-with-rsa-for-17-years
#13
Maziar Mohaddes, Peter Herberts, Henrik Malchau, Per-Erik Johanson, Johan Kärrholm
BACKGROUND: Bone impaction grafting is a biologically and mechanically appealing option in acetabular revision surgery, allowing restitution of the bone stock and restoration of the biomechanics. We analysed differences in proximal migration of the revision acetabular components when bone impaction grafting is used together with a cemented or an uncemented cup. PATIENTS AND METHODS: 43 patients (47 hips), revised due to acetabular loosening and judged to have less than 50% host bone-implant contact were included...
November 22, 2016: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/27857822/revision-of-metal-on-metal-hip-arthroplasty-with-well-fixed-and-positioned-acetabular-component-using-a-dual-mobility-head-and-review-of-literature
#14
Guillem Figueras, Ramón Vives Planell, Ramón Serra Fernàndez, Joan Camí Biayna
BACKGROUND: As a consequence of use of metal-on-metal hip arthroplasties some patients have precised revision for pain or metal hipersensivity reactions among other causes. We propose to salvage monoblock acetabular component and femoral component using a dual-mobility head and perform a lower morbidity operation in young patients preserving host bone stock in cases with well fixed and positioned components. OBJECTIVE: (1) What clinical problems have been reported in patients with Metal-on-metal hip arthroplasties? (2) Could the tribocorrosion potentially cause a fracture of neck femoral component? (3) Can be the dual-mobility head a recourse in metal-on-metal hip revision? METHODS: Ten patients were revised for pain or/and raised Cobalt/Chromium levels between August 2012 and December 2015...
2016: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/27846875/the-design-of-a-randomised-controlled-trial-to-evaluate-the-cost-effectiveness-of-the-posterolateral-versus-the-direct-anterior-approach-for-tha-polada-trial
#15
K Rykov, I H F Reininga, B A S Knobben, M S Sietsma, B L E F Ten Have
BACKGROUND: Total hip arthroplasty (THA) is one of the most successful orthopaedic procedures. Because of the increasing number of THAs, a growing demand for faster recovery and a greater emphasis on cost-effectiveness, minimally invasive THAs have been introduced in the last decades. The direct anterior approach is a minimally invasive, tissue-sparing approach in which intermuscular planes are used. Theoretically, this approach should result in a faster recovery of physical functioning and higher health-related quality of life...
November 15, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27821999/early-results-of-the-lps%C3%A2-limb-preservation-system-in-the-management-of-periprosthetic-femoral-fractures
#16
M Curtin, C Bryan, E Murphy, C G Murphy, W Curtin
INTRODUCTION: Achieving skeletal fixation in the presence of progressive bone loss is a surgical challenge, especially in cases of periprosthetic fracture (PPF). Unpredictable fracture patterns and preexisting bone loss frequently combine in this patient group. Megaprosthetic arthroplasty allows for immediate mobilisation and shorter periods of rehabilitation. We describe the clinical outcomes of a cohort of LPS™ megaprostheses performed for PPF by a single surgeon at our institution...
March 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/27819644/patient-specific-instruments-for-complex-tumor-resection-reconstruction-surgery-within-the-pelvis-a-series-of-4-cases
#17
Eduard Cernat, Pierre-Louis Docquier, Laurent Paul, Xavier Banse, Ion-Bogdan Codorean
The pelvis bone resection-reconstruction surgery is one of the most challenging fields in orthopedics. Being applied for tumors, as for other complex reconstruction cases, this type of surgery needs careful planning and is time consuming, in order to obtain proper accuracy. Unfortunately not all the time the expected accuracy is met, with consequences for the patients. PSI proved to provide good cutting accuracy during simulated tumor surgery within the pelvis. This article present a series of 4 patients operated in our department between June 2014 and Mars 2015 for tumors resectionreconstructions...
2016: Chirurgia
https://www.readbyqxmd.com/read/27817994/favorable-early-results-of-impaction-bone-grafting-with-reinforcement-mesh-for-the-treatment-of-paprosky-3b-acetabular-defects
#18
Bradford S Waddell, Friedrich Boettner, Alejandro Gonzalez Della Valle
BACKGROUND: We present the early institutional experience with the use of impaction bone grafting, mesh augmentation, and cement fixation of an all-polyethylene cup for the treatment of Paprosky 3B acetabular defects during revision total hip arthroplasty. METHODS: Between 2005 and 2014, 21 patients (9 men, 12 women) with Paprosky 3B acetabular defects who underwent revision total hip arthroplasty using this technique were reviewed clinically and radiographically...
October 5, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27803218/the-exeter-universal-cemented-femoral-stem-at-20-to-25-years-a-report-of-382-hips
#19
T G Petheram, S L Whitehouse, H A Kazi, M J W Hubble, A J Timperley, M J Wilson, J R Howell
AIMS: We present a minimum 20-year follow-up study of 382 cemented Exeter Universal total hip arthroplasties (350 patients) operated on at a mean age of 66.3 years (17 to 94). PATIENTS AND METHODS: All patients received the same design of femoral component, regardless of the original diagnosis. Previous surgery had been undertaken for 33 hips (8.6%). During the study period 218 patients with 236 hips (62%) died, 42 hips (11%) were revised and 110 hips (29%) in 96 patients were available for review...
November 2016: Bone & Joint Journal
https://www.readbyqxmd.com/read/27791415/nine-year-results-of-whole-femoral-head-allograft-with-articular-cartilage-for-acetabular-impaction-grafting-in-revision-hip-replacement
#20
E Drampalos, A Fadulelmola, R Mohammed, D Shaw, S Subramanian, K D Jain, J Hodgkinson
INTRODUCTION Acetabular impaction bone grafting with a cemented polyethylene socket aims to reconstitute the bone stock in hip revision. This is an effective but resource intensive and time consuming technique. Usually, the articular cartilage is removed from the femoral head allograft. Our objective was to assess the late results of using the whole femoral head, retaining the cartilage. METHODS Forty-two acetabular revisions using impacted morselised bone graft (retaining the articular cartilage) and a cemented socket were studied retrospectively...
October 28, 2016: Annals of the Royal College of Surgeons of England
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