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Jizhen Lin

Xiaoli Chen, Yu An, Yonghui Gao, Liu Guo, Lei Rui, Hua Xie, Mei Sun, Siv Lam Hung, Xiaoming Sheng, Jizhen Zou, Yihua Bao, Hongyan Guan, Bo Niu, Zandong Li, Richard H Finnell, James F Gusella, Bai-Lin Wu, Ting Zhang
Increasing evidence that mutation of planar cell polarity (PCP) genes contributes to human cranial NTD susceptibility prompted us to hypothesize that rare variants of genes in the core apical-basal polarity (ABP) pathway are risk factors for cranial NTDs. In this study, we screened for rare genomic variation of PARD3 in 138 cranial NTD cases and 274 controls. Overall, the rare deleterious variants of PARD3 were significantly associated with increased risk for cranial NTDs (11/138 vs.7/274, p<0.05, OR = 3...
December 7, 2016: Human Mutation
Lin Su, Zhen Zhang, Liang Gan, Qian Jiang, Ping Xiao, Jizhen Zou, Qi Li, Hong Jiang
Hirschsprung disease (HSCR) is a congenital disorder characterized by the absence of intrinsic ganglion cells in the lower intestine. Genetic factors in the pathogenesis of this disease are under active investigation. As core genes in the planar cell polarity pathway, Celsr3 and Fzd3 are believed to play vital roles in the development of the murine enteric nervous system. The potential association of CELSR3 and FZD3 with the development of HSCR in humans, however, is still unknown. We determined the genotypes of eight CELSR3 and FZD3 polymorphisms in 113 patients...
September 13, 2016: Experimental and Molecular Pathology
Lin Wang, Yan Sun, Jiqun Yi, Xiuwen Wang, Jizhen Liang, Zhaojun Pan, Li Li, Gaofeng Jiang
BACKGROUND: Lung cancer is one of the most common and a lethal malignancy in the world and non-small cell lung cancer (NSCLC) is the most usual type. H19 long non-coding RNA (lncRNA) plays essential roles in tumor development. But its role in tumor metastasis is still unclear. MATERIALS AND METHODS: MACC1 RNAi and Lentivirus-mediated H19-specific shRNA was used to establish H19 stable knocking-down A549 cells. Transwell assays were performed to examine the effect of H19 knocking-down on A549 cells migration and invasion...
September 2016: Experimental Lung Research
Xiaomin Fu, Yong Zhang, Quanli Gao, Jizhen Lin, Qinxian Zhang, Benling Xu, Yongping Song
Idiopathic thrombocytopenic purpura (ITP) is characterized by a diminished platelet count, an autoimmune condition with antibodies against platelets and an increased tendency to bleed. The association between ITP and solid tumors is uncommon. Cytokine-induced killer (CIK) cell therapy is a well tolerated and promising cancer treatment with minimal toxicity. For the first time, CIK cell therapy was reported to be followed by ITP. The mechanism through which CIK induces ITP remains unclear. Imbalanced ratio of Th cells, decreased numbers or impaired function of Treg cells and excessive secretion of cytokines inducing abnormal activation of B cells may be among the possible reasons...
September 2016: Immunotherapy
Jizhen Wei, Gemei Liang, Bingjie Wang, Feng Zhong, Lin Chen, Myint Myint Khaing, Jie Zhang, Yuyuan Guo, Kongming Wu, Bruce E Tabashnik
Crystalline (Cry) proteins from Bacillus thuringiensis (Bt) are used extensively for insect control in sprays and transgenic plants, but their efficacy is reduced by evolution of resistance in pests. Here we evaluated reduced activation of Cry1Ac protoxin as a potential mechanism of resistance in the invasive pest Helicoverpa armigera. Based on the concentration killing 50% of larvae (LC50) for a laboratory-selected resistant strain (LF120) divided by the LC50 for its susceptible parent strain (LF), the resistance ratio was 1600 for Cry1Ac protoxin and 1200 for trypsin-activated Cry1Ac toxin...
2016: PloS One
Zhiguang Ren, Xiaoke Gu, Bin Lu, Yaqiong Chen, Guojiang Chen, Jiannan Feng, Jizhen Lin, Yihua Zhang, Hui Peng
The development of multidrug resistance (MDR) not only actively transports a wide range of cytotoxic drugs across drug transporters but is also a complex interaction between a number of important cellular signalling pathways. Nitric oxide donors appear to be a new class of anticancer therapeutics for satisfying all the above conditions. Previously, we reported furoxan-based nitric oxide-releasing compounds that exhibited selective antitumour activity in vitro and in vivo. Herein, we demonstrate that bifendate (DDB)-nitric oxide, a synthetic furoxan-based nitric oxide-releasing derivative of bifendate, effectively inhibits the both sensitive and MDR tumour cell viability at a comparatively low concentration...
June 2016: Journal of Cellular and Molecular Medicine
Zhigang Miao, Yuquan He, Ning Xin, Miao Sun, Li Chen, Li Lin, Jizhen Li, Jiming Kong, Peng Jin, Xingshun Xu
Epigenetic modifications such as cytosine methylation and histone modification are linked to the pathology of ischemic brain injury. Recent research has implicated 5-hydroxymethylcytosine (5hmC), a DNA base derived from 5-methylcytosine (5mC) via oxidation by ten-eleven translocation (Tet) enzymes, in DNA methylation-related plasticity. Here we show that 5hmC abundance was increased after ischemic injury, and Tet2 was responsible for this increase; furthermore, inhibiting Tet2 expression abolished the increase of 5hmC caused by ischemic injury...
October 15, 2015: Human Molecular Genetics
Xiaolan Lai, Jinrong Liao, Wansong Lin, Chuanzhong Huang, Jieyu Li, Jizhen Lin, Qiang Chen, Yunbin Ye
Inhibitor of DNA-binding protein 1 (ID1) is commonly abnormally overexpressed in colorectal cancer (CRC); yet, the functional significance of ID1 in the growth and invasive properties of CRC cells remains largely unclear. The present study investigated the effects of ID1 downregulation on the cell growth and metastatic features of CRC. Using lentiviral shRNA infection, stable ID1-knockdown (KD) HCT116 and SW620 cells, human metastatic CRC cell lines, were created. In vitro, the migration/invasion capacity of the ID1-KD CRC cells was assessed by a wound healing assay...
July 2014: Oncology Reports
Jinhuo Lai, Qian Cai, Merrill A Biel, Chuan Wang, Xiaohua Hu, Shaoyuan Wang, Jizhen Lin
Id1 and NF-κB are highly expressed in oral squamous cell carcinoma (OSCC). Whether they have a synergistic role in the carcinogenesis of OSCC is unclear. The current study was designed to demonstrate the synergy of both Id1 and NF-κB in the underlying disease mechanisms of OSCC using in vitro and in vivo animal models. Id1 and NF-κB strengthened the expression of both CD133 and BMI-1 in OSCC cell cultures. CD133(+) and BMI-1(+) keratinocytes from OSCC tissues and cell cultures initiated the growth of xenograft tumors in SCID/Beige mice...
May 2014: International Journal of Oncology
Alan W Johnson, James D Sidman, Jizhen Lin
OBJECTIVES: Bioluminescent imaging has emerged as a powerful tool for monitoring the pathological process of infections in animals. The purpose of this study was to harness this new tool for objective assessment of acute otitis media (AOM) in animals with and without antibiotic interventions. METHODS: Thirty-six healthy chinchillas, free of middle ear infections, were randomly divided into a control group and a group that received amoxicillin treatment. Bioluminescent Streptococcus pneumoniae (Xen 10) was injected into the epitympanic bullae of chinchillas (50 colony-forming units each) for induction of AOM...
May 2013: Annals of Otology, Rhinology, and Laryngology
Yoshihisa Nakamura, Masahiro Komori, Kazuhiro Yamakawa, Yuki Hamajima, Motohiko Suzuki, Youngki Kim, Jizhen Lin
BACKGROUND: A key issue in otitis media (OM) is mucous cell metaplasia in the middle ear mucosa, a condition for hyperproduction of mucus in the middle ear mucosa and development of chronic OM. However, little is known about the driving force for the differentiation of mucous cells in OM. METHODS: Mouse middle ear epithelial cells (mMEECs) were used in this study to test whether Math1, a critical transcription factor for the development of mucous cells in the intestine, synergizes with inflammatory cytokines (tumor necrosis factor-α (TNF-α)) and other epithelial differentiation factors (retinoid acid (RA)) to induce the differentiation of mMEECs into mucus-like cells in vitro...
September 2013: Pediatric Research
Shinji Fukudome, Chuan Wang, Yuki Hamajima, Shengnan Ye, Yiqing Zheng, Norihiko Narita, Hiroshi Sunaga, Shigeharu Fujieda, Xiaohua Hu, Ling Feng, Jizhen Lin
IMPORTANCE: The aggressive growth of cholesteatoma in the middle ear involves the angiogenesis of the cholesteatomal perimatrix. However, which transcription factor is involved in this process remains unclear. OBJECTIVE: To identify a transcription factor that supports the aggressive growth of cholesteatoma by controlling the angiogenesis of cholesteatoma in the middle ear milieu. DESIGN: We used clinical specimens for the profiling of angiogenic factors and their regulatory transcription factors in cholesteatoma...
March 2013: JAMA Otolaryngology—Head & Neck Surgery
Jian-Dong Li, Ann Hermansson, Allen F Ryan, Lauren O Bakaletz, Steve D Brown, Michael T Cheeseman, Steven K Juhn, Timothy T K Jung, David J Lim, Jae Hyang Lim, Jizhen Lin, Sung-Kyun Moon, J Christopher Post
BACKGROUND: Otitis media (OM) is the most common childhood bacterial infection and also the leading cause of conductive hearing loss in children. Currently, there is an urgent need for developing novel therapeutic agents for treating OM based on full understanding of molecular pathogenesis in the areas of molecular biology, biochemistry, genetics, and animal model studies in OM. OBJECTIVE: To provide a state-of-the-art review concerning recent advances in OM in the areas of molecular biology, biochemistry, genetics, and animal model studies and to discuss the future directions of OM studies in these areas...
April 2013: Otolaryngology—Head and Neck Surgery
Per Cayé-Thomasen, Ann Hermansson, Lauren Bakaletz, Sten Hellstrøm, Sho Kanzaki, Joseph Kerschner, David Lim, Jizhen Lin, Kevin Mason, Jorge Spratley
BACKGROUND AND OBJECTIVES: The pathogenesis of otitis media (OM) involves a number of factors related to the anatomy, pathology, and cell biology of the middle ear, the mastoid, the Eustachian tube, and the nasopharynx. Although some issues of pathogenesis are fairly well established, others are only marginally indicated by current knowledge, and yet others remain undisclosed. The objective of this article is to provide a state-of-the-art review on recent scientific achievements in the pathogenesis of OM, as related to anatomy, pathology, and cell biology...
April 2013: Otolaryngology—Head and Neck Surgery
Xiaoli Chen, Yiping Shen, Yonghui Gao, Huizhi Zhao, Xiaoming Sheng, Jizhen Zou, Va Lip, Hua Xie, Jin Guo, Hong Shao, Yihua Bao, Jianliang Shen, Bo Niu, James F Gusella, Bai-Lin Wu, Ting Zhang
BACKGROUND: Neural tube defects (NTDs) are one of the most common birth defects caused by a combination of genetic and environmental factors. Currently, little is known about the genetic basis of NTDs although up to 70% of human NTDs were reported to be attributed to genetic factors. Here we performed genome-wide copy number variants (CNVs) detection in a cohort of Chinese NTD patients in order to exam the potential role of CNVs in the pathogenesis of NTDs. METHODS: The genomic DNA from eighty-five NTD cases and seventy-five matched normal controls were subjected for whole genome CNVs analysis...
2013: PloS One
Jizhen Lin, Joseph E Kerschner, Per Cayé-Thomasen, Tetsuya Tono, Quan-An Zhang
No abstract text is available yet for this article.
2012: International Journal of Otolaryngology
Jizhen Lin, Per Caye-Thomasen, Tetsuya Tono, Quan-An Zhang, Yoshihisa Nakamura, Ling Feng, Jianmin Huang, Shengnan Ye, Xiaohua Hu, Joseph E Kerschner
Otitis media (OM) with mucoid effusion, characterized by mucous cell metaplasia/hyperplasia in the middle ear cleft and thick fluid accumulation in the middle ear cavity, is a subtype of OM which frequently leads to chronic OM in young children. Multiple factors are involved in the developmental process of OM with mucoid effusion, especially disorders of mucin production resulting from middle ear bacterial infection and Eustachian tube dysfunction. In this review, we will focus on several aspects of this disorder by analyzing the cellular and molecular events such as mucin production and mucous cell differentiation in the middle ear mucosa with OM...
2012: International Journal of Otolaryngology
Yoshihisa Nakamura, Yuki Hamajima, Masahiro Komori, Makoto Yokota, Motohiko Suzuki, Jizhen Lin
A key issue in otitis media is mucous cell metaplasia which is responsible for mucous hypersecretion and persistence of the disease. However, little is known about the molecular mechanisms of mucous cell metaplasia in otitis media. Numerous studies of intestinal epithelial homeostasis have shown that Atonal homolog 1 (Atoh1), a basic helix-loop-helix (bHLH) transcription factor, is essential for the intestinal goblet cell differentiation. On the other hand, SAM-pointed domain-containing Ets transcription factor (SPDEF), a member of the "Ets" transcription factor family, has been reported to trigger the mucous cell metaplasia of pulmonary infectious diseases or athsma...
2012: International Journal of Otolaryngology
Yun-Woo Lee, Yunju Chung, Steven K Juhn, Youngki Kim, Jizhen Lin
OBJECTIVES: Granulation tissue is common in otitis media (OM), yet little is known about the signaling pathways in the formation of granulation tissue in response to infections. In this study, we sought to investigate the activation of the transforming growth factor beta (TGF-beta) signaling pathway in the formation of granulation tissue in response to middle ear pathogens. METHODS: Rat OM models were made by inoculating pneumococcus type 6A or nontypeable Haemophilus influenzae into the middle ear cavity or by obstructing the eustachian tube...
March 2011: Annals of Otology, Rhinology, and Laryngology
Masahiro Komori, Yoshihisa Nakamura, Jesse Ping, Ling Feng, Katsuhiro Toyama, Youngki Kim, Patricia Ferrieri, Jizhen Lin
Toll-like receptor 2 (TLR2) plays a key role in the host defense against Gram staining positive (Gram) bacteria and their cell wall envelope components. However, little is known about the expression of TLR2 in the middle ear under otitis media (OM) conditions, and its role in the persistent otitis media with effusion (OME). In this study, we demonstrated that the pneumococcal cell wall component, peptidoglycan-polysaccharides (PGPS), activated the expression of TLR2 in the middle ear epithelial cells through the nuclear factor kappa B (NF-κB)-cytokine signaling pathway while I kappa B alpha mutant (IκBαM), a dominant negative inhibitor of NF-κB, abrogated the expression of TLR2 induced by PGPS...
February 2011: Pediatric Research
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