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https://www.readbyqxmd.com/read/29151280/oral-nutritional-supplementation-in-patients-undergoing-peritoneal-dialysis-a-randomised-crossover-pilot-study
#1
Karen M Salamon, Kelly Lambert
BACKGROUND: Malnutrition is a significant problem in those undergoing peritoneal dialysis (PD). Factors such as gastrointestinal (GI) symptoms and the need for a fluid reduced diet can limit tolerance and thereby the efficacy of oral nutritional supplements to treat malnutrition. OBJECTIVES: To evaluate the acceptability and impact of two different forms of oral nutrition supplementation for 16 weeks on nutritional markers and quality of life of malnourished patients undergoing PD...
November 19, 2017: Journal of Renal Care
https://www.readbyqxmd.com/read/29151276/microbial-growth-in-building-material-samples-and-occupants-health-in-severely-moisture-damaged-homes
#2
K Järvi, A Hyvärinen, M Täubel, A M Karvonen, M Turunen, K Jalkanen, R Patovirta, T Syrjänen, J Pirinen, H Salonen, A Nevalainen, J Pekkanen
There is no commonly approved approach to detect and quantify the health relevant microbial exposure in moisture damaged buildings. In 39 single-family homes with severe moisture damage, we studied whether concentrations of viable microbes in building material samples are associated with health among 71 adults and 68 children, assessed with symptoms questionnaires, exhaled NO and peak expiratory flow (PEF) variability. Symptoms were grouped into three scores: upper respiratory symptoms, lower respiratory symptoms and general symptoms...
November 19, 2017: Indoor Air
https://www.readbyqxmd.com/read/29151273/post-treatment-with-methylene-blue-is-effective-against-delayed-encephalopathy-after-acute-carbon-monoxide-poisoning
#3
Ningjun Zhao, Pengchong Liang, Xiaoying Zhuo, Chenglei Su, Xuemei Zong, Bingnan Guo, Han Dong, Xianliang Yan, Shuqun Hu, Quanguang Zhang, Xu Tie
Delayed encephalopathy after acute carbon monoxide (CO) poisoning (DEACMP) is the most severe and clinically intractable complication that occurs following acute carbon monoxide poisoning. Unfortunately, the mechanism of DEACMP is still vague. Growing evidence indicates that delayed cerebral damage following CO poisoning is related to oxidative stress, abnormal neuro-inflammation, apoptosis and immune-mediated injury. Our recent report indicated that methylene blue (MB) may be a promising therapeutic agent in the prevention of neuronal cell death and cognitive deficits following transient global cerebral ischaemia (GCI)...
November 19, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29151199/loneliness-in-older-adults-living-with-hiv
#4
Meredith Greene, Nancy A Hessol, Carla Perissinotto, Roland Zepf, Amanda Hutton Parrott, Cameron Foreman, Robert Whirry, Monica Gandhi, Malcolm John
We conducted a cross-sectional study among HIV-positive adults age ≥ 50 in San Francisco to evaluate the frequency of loneliness, characteristics of those who reported loneliness, and the association of loneliness with functional impairment and health-related quality of life (HRQoL). Participants (N = 356) were predominately male (85%); 57% were white; median age was 56. 58% reported any loneliness symptoms with 24% reporting mild, 22% moderate and 12% severe loneliness. Lonely participants were more likely to report depression, alcohol and tobacco use, and have fewer relationships...
November 18, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29151174/the-impact-of-remission-status-on-patients-experiences-with-acute-myeloid-leukemia-aml-an-exploratory-analysis-of-longitudinal-patient-reported-outcomes-data
#5
Neha Kayastha, Steven P Wolf, Susan C Locke, Gregory P Samsa, Areej El-Jawahri, Thomas W LeBlanc
PURPOSE: Shared decision-making in acute myeloid leukemia (AML) requires understanding patients' longitudinal experiences of illness, but little is known about the impact of remission status on patient-reported outcomes (PROs). We aimed to explore the association between remission status and PROs 6-12 months following induction chemotherapy. METHODS: Forty-two patients completed three validated instruments characterizing symptom burden (Patient Care Monitor v2...
November 18, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29151148/development-and-preliminary-validation-of-the-food-intolerance-quality-of-life-questionnaire-fiqlq-adult-form
#6
Audrey DunnGalvin, Julie Barnett, Fiona M Begen, Kathleen Ryan, Jane S Lucas
BACKGROUND: Approximately 20% of children and adults avoid certain foods because of perceived food intolerance. Valid and reliable health-related quality of life instruments are needed to measure changes following clinical, therapeutic or policy interventions. However, there are no disease-specific quality of life instruments for adults with food intolerances. OBJECTIVE: To develop the Food Intolerance Quality of Life Questionnaire FIQLQ. Then to conduct psychometric validation including reliability and construct validity...
November 18, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/29151129/one-novel-and-two-uncommon-mefv-mutations-in-japanese-patients-with-familial-mediterranean-fever-a-clinicogenetic-study
#7
Dai Kishida, Masahide Yazaki, Akinori Nakamura, Fumio Nomura, Takeshi Kondo, Takanori Uehara, Masatomi Ikusaka, Akira Ohya, Norihiko Watanabe, Ryuta Endo, Satoshi Kawaai, Yasuhiro Shimojima, Yoshiki Sekijima
Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by mutations in the MEFV gene and characterized by recurrent episodes of fever and polyserositis. To date, over 317 MEFV mutations have been reported, only nine of which account for almost all Japanese patients with FMF. Therefore, the prevalence of rare MEFV variants and their clinical characteristics remains unclear. This study identified MEFV mutations previously unreported in the Japanese population and described their clinical features...
November 18, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29151115/supramodal-effect-of-rightward-prismatic-adaptation-on-spatial-representations-within-the-ventral-attentional-system
#8
Isabel Tissieres, Eleonora Fornari, Stephanie Clarke, Sonia Crottaz-Herbette
Rightward prismatic adaptation (R-PA) was shown to alleviate not only visuo-spatial but also auditory symptoms in neglect. The neural mechanisms underlying the effect of R-PA have been previously investigated in visual tasks, demonstrating a shift of hemispheric dominance for visuo-spatial attention from the right to the left hemisphere both in normal subjects and in patients. We have investigated whether the same neural mechanisms underlie the supramodal effect of R-PA on auditory attention. Normal subjects underwent a brief session of R-PA, which was preceded and followed by an fMRI evaluation during which subjects detected targets within the left, central and right space in the auditory or visual modality...
November 18, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29151093/munchausen-syndrome-and-the-wide-spectrum-of-factitious-disorders
#9
Laurent Tatu, Selma Aybek, Julien Bogousslavsky
Since its initial description in 1851, Munchausen syndrome has been widely used interchangeably with factitious disorder. Nevertheless, this syndrome is only one form of factitious disorder that is both severe and chronic. The syndrome was named after Karl Friedrich Hieronymus, Baron von Münchhausen (1720-1797), a German nobleman who became famous as a narrator of false and exaggerated exploits. His name was progressively corrupted to Munchausen. Factitious disorders and Munchausen syndrome remain a great diagnosis challenge for physicians...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29151092/conversion-factitious-disorder-and-malingering-a-distinct-pattern-or-a-continuum
#10
Silvio Galli, Laurent Tatu, Julien Bogousslavsky, Selma Aybek
This chapter is aimed at highlighting the recent findings concerning physiopathology, diagnosis, and management of conversion, factitious disorder, and malingering. Conversion disorder is the unintentional production of neurological symptom, whereas malingering and factitious disorder represent the voluntary production of symptoms with internal or external incentives. They have a close history and this has been frequently confounded. Practitioners are often confronted to medically unexplained symptoms; they represent almost 30% of neurologist's consultation...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29151090/de-cl%C3%A3-rambault-syndrome-othello-syndrome-folie-%C3%A3-deux-and-variants
#11
Montserrat G Delgado, Julien Bogousslavsky
Non-bizarre delusion, defined as a false belief possible although highly unlikely, is the main manifestation of delusional disorders, previously known as paranoia. Based on the predominant delusional themes, 5 main subtypes may be described - erotomanic, grandiose, jealous, persecutory, and somatic. We present here 2 main delusional disorders, the De Clérambault syndrome and the Othello syndrome, and another closely related to the previous ones - Folie à deux. In the De Clérambault syndrome, the main delusional theme is erotomanic type, related to passional delirium where the patient has strong sexual feelings towards another person and has the belief that this other person is deeply in love with him or her...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29151087/ganser-syndrome
#12
Sebastian Dieguez
Ganser's syndrome is a rare and controversial condition, whose main and most striking feature is the production of approximate answers (or near misses) to very simple questions. For instance, asked how many legs a horse has, Ganser patients will reply "5", and answers to plain arithmetic questions will likewise be wrong, but only slightly off the mark (e.g., 2 + 2 = 3). This symptom was originally described by Sigbert Ganser in 1897 in prisoners on remand and labeled Vorbeigehen ("to pass by"), although the term Vorbeireden ("to talk beside the point") is also frequently used...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29151060/genetics-of-parkinson-s-disease-and-related-disorders
#13
REVIEW
Pei-Lan Zhang, Yan Chen, Chen-Hao Zhang, Yu-Xin Wang, Pedro Fernandez-Funez
Parkinson's disease (PD) is a complex and heterogeneous neurological condition characterised mainly by bradykinesia, resting tremor, rigidity and postural instability, symptoms that together comprise the parkinsonian syndrome. Non-motor symptoms preceding and following clinical onset are also helpful diagnostic markers revealing a widespread and progressive pathology. Many other neurological conditions also include parkinsonism as primary or secondary symptom, confounding their diagnosis and treatment. Although overall disease course and end-stage pathological examination single out these conditions, the significant overlaps suggest that they are part of a continuous disease spectrum...
November 18, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29151042/patient-centered-assessment-on-disease-burden-quality-of-life-and-treatment-satisfaction-associated-with-acromegaly
#14
Shuqian Liu, Daphne T Adelman, Yaping Xu, Jillone Sisco, Susan M Begelman, Susan M Webb, Xavier Badia, Tina K Thethi, Vivian Fonseca, Lizheng Shi
The study aimed to assess the economic burden, health-related quality of life (HRQoL), and acromegaly treatment satisfaction in the USA. A web-based, cross-sectional survey was distributed to members of Acromegaly Community. Data related to comorbidities, treatment patterns, and treatment satisfaction were collected. The costs over the past 3 months included out-of-pocket cost, sick leave, leave of absence, direct loss of job due to acromegaly, unemployment, assistance to perform household chores, and family member loss of income...
November 18, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29151041/assessment-of-thrombus-length-in-acute-ischemic-stroke-by-post-contrast-magnetic-resonance-angiography
#15
Ramanan Ganeshan, Alexander H Nave, Jan F Scheitz, Katharina A Schindlbeck, Karl Georg Haeusler, Christian H Nolte, Kersten Villringer, Jochen B Fiebach
OBJECTIVES: Post-contrast magnetic resonance angiography (PC-MRA) enables visualization of vessel segments distal to an intra-arterial thrombus in acute ischemic stroke. We hypothesized that PC-MRA also allows clot length measurement in different intracranial vessels. METHODS: Patients with MRI-confirmed ischemic stroke and intracranial artery occlusion within 24 hours of symptom onset were prospectively evaluated. PC-MRA was added to a standard stroke MRI protocol...
November 18, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29151022/quality-of-care-for-people-with-multimorbidity-a-case-series
#16
Michaela L Schiøtz, Dorte Høst, Mikkel B Christensen, Helena Domínguez, Yasmin Hamid, Merete Almind, Kim L Sørensen, Thomas Saxild, Rikke Høgsbro Holm, Anne Frølich
BACKGROUND: Multimorbidity is becoming increasingly prevalent and presents challenges for healthcare providers and systems. Studies examining the relationship between multimorbidity and quality of care report mixed findings. The purpose of this study was to investigate quality of care for people with multimorbidity in the publicly funded healthcare system in Denmark. METHODS: To investigate the quality of care for people with multimorbidity different groups of clinicians from the hospital, general practice and the municipality reviewed records from 23 persons with multimorbidity and discussed them in three focus groups...
November 18, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29151006/the-practical-update-for-family-physicians-in-the-diagnosis-and-management-of-overactive-bladder-and-lower-urinary-tract-symptoms
#17
Jack Barkin, Jeffrey Habert, Amy Wong, Livia Y T Lee
OBJECTIVE: To provide family physicians with an up-to-date, practical overview of the diagnosis and management of overactive bladder (OAB) alone or with bladder outlet obstruction. MAIN MESSAGE: OAB is urinary urgency with or without incontinence, often accompanied by frequency and nocturia, in the absence of urinary tract infection and can affect both men and women. Men often have co-existing OAB associated with bladder outlet obstruction, and benign prostatic hyperplasia...
October 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29150985/general-illness-and-psychological-factors-in-patients-with-chronic-nasal-symptoms
#18
Naveed Kara, Alexander C Yao, Julia Newton, Vincent Deary, James O'Hara, Janet A Wilson
OBJECTIVES: Only a minority of patients referred to specialists with sinonasal symptoms have clear evidence of chronic rhinosinusitis. This study aims to estimate the prevalence of and associations between (i) general illness factors (fatigue, autonomic dysfunction) and (ii) psychological factors (anxiety, depression, somatisation, personality traits) in patients presenting with sinonasal symptoms. DESIGN: The following validated questionnaires were administered to patients: the Sino-Nasal Outcome Test-22 (SNOT-22) to identify symptom burden, Composite Autonomic Symptom Score-31 (COMPASS-31) measuring autonomic function, Chalder fatigue questionnaire, Patient Health Questionnaire-15 (PHQ-15) addressing somatisation symptoms, Hospital Anxiety and Depression Scale (HADS), and the International Personality Item Pool-50 (IPIP-50)...
November 18, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29150972/patient-level-factors-and-the-quality-of-care-delivered-in-pediatric-emergency-departments
#19
James P Marcin, Patrick S Romano, Parul Dayal, Madan Dharmar, James M Chamberlain, Nanette Dudley, Charles G Macias, Lise E Nigrovic, Elizabeth C Powell, Alexander J Rogers, Meridith Sonnett, Leah Tzimenatos, Elizabeth R Alpern, Rebecca Andrews-Dickert, Dominic A Borgialli, Erika Sidney, T Charles Casper, J Michael Dean, Nathan Kuppermann
OBJECTIVE: Quality of care delivered to adult patients in the emergency department (ED) is often associated with demographic and clinical factors such as a patient's race/ethnicity and insurance status. We sought to determine whether the quality of care delivered to children in the ED was associated with a variety of patient-level factors. METHODS: This was a retrospective, observational cohort study. Pediatric patients (<18 years) who received care between January 2011 and December 2011 at one of twelve EDs participating in the Pediatric Emergency Care Applied Research Network (PECARN) were included...
November 18, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29150969/non-operative-treatment-as-a-strategy-for-patients-with-parastomal-hernia-a-multicentre-retrospective-cohort-study
#20
L F Kroese, D P V Lambrichts, J Jeekel, G J Kleinrensink, A G Menon, E J R de Graaf, W A Bemelman, J F Lange
AIM: Parastomal hernia is the most common complication following stoma construction. Surgical treatment is usually chosen over non-operative treatment, but a clear rationale for the choice of management is often lacking. This study aims to investigate the reasons for non-operative treatment, cross-over rates, and postoperative complications. METHOD: A multicentre, retrospective cohort study was conducted. Patients diagnosed with a parastomal hernia between January 2007 and December 2012 were included...
November 18, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
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