Xinyao Meng, Jun Xiao, Jing Wang, Minxian Sun, Xuyong Chen, Luyao Wu, Ke Chen, Zejian Li, ChenZhao Feng, Didi Zhuansun, Jixin Yang, Xiaojuan Wu, Donghai Yu, Wei Li, Yonghua Niu, Ying He, Mingfa Wei, Feng Chen, Bo Xiong, Jiexiong Feng, Tianqi Zhu
OBJECTIVE AND DESIGN: Hirschsprung disease-associated enterocolitis (HAEC) is a common life-threatening complication of Hirschsprung disease (HSCR). We aimed to investigate the effectiveness, long-term safety and the underlying mechanisms of Mesenchymal stem cells (MSCs) based therapy for HAEC. MATERIAL OR SUBJECTS: Specimens from HSCR and HAEC patients were used to assess the inflammatory condition. Ednrb knock-out mice was used as HAEC model. MSCs was intraperitoneally transplanted into HAEC mice...
March 4, 2024: Journal of Pediatric Surgery