Malte Christoph Rühlemann, Britt Marie Hermes, Corinna Bang, Shauni Doms, Lucas Moitinho-Silva, Louise Bruun Thingholm, Fabian Frost, Frauke Degenhardt, Michael Wittig, Jan Kässens, Frank Ulrich Weiss, Annette Peters, Klaus Neuhaus, Uwe Völker, Henry Völzke, Georg Homuth, Stefan Weiss, Harald Grallert, Matthias Laudes, Wolfgang Lieb, Dirk Haller, Markus M Lerch, John F Baines, Andre Franke
The intestinal microbiome is implicated as an important modulating factor in multiple inflammatory1,2 , neurologic3 and neoplastic diseases4 . Recent genome-wide association studies yielded inconsistent, underpowered and rarely replicated results such that the role of human host genetics as a contributing factor to microbiome assembly and structure remains uncertain5-11 . Nevertheless, twin studies clearly suggest host genetics as a driver of microbiome composition11 . In a genome-wide association analysis of 8,956 German individuals, we identified 38 genetic loci to be associated with single bacteria and overall microbiome composition...
January 18, 2021: Nature Genetics