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Heike Hoyer-Kuhn, Laura Höbing, Julia Cassens, Eckhard Schoenau, Oliver Semler
BACKGROUND: Osteogenesis imperfecta (OI) is characterized by bone fragility and short stature. Data about IGF-I/IGFBP-3 levels are rare in OI. Therefore IGF-I/IGFBP-3 levels in children with different types of OI were investigated. METHODS: IGF-I and IGFBP-3 levels of 60 children (male n=38) were assessed in a retrospective cross-sectional setting. RESULTS: Height/weight was significant different [height z-score type 3 versus type 4: p=0.0011 and weight (p≤0...
July 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
Tomoki Kimura, Hiroyuki Taniguchi, Naohiro Watanabe, Hideo Saka, Yoshihito Kogure, Joe Shindo, Tomohiko Ogasawara, Eiji Kojima, Yoshinori Hasegawa, Masashi Yamamoto, Ryujiro Suzuki, Masahiko Ando, Masashi Kondo, Hiroshi Saito
BACKGROUND: Several pre-clinical and clinical studies suggest a potential predictive role of epidermal growth factor receptor (EGFR) mutation in responsiveness to cytotoxic chemotherapy. The aim of this phase II study was to evaluate the efficacy and safety of pemetrexed-carboplatin combination as first-line chemotherapy in advanced non-squamous non-small cell lung cancer (NSCLC) limited to EGFR-wild-type cases. PATIENTS AND METHODS: In this single-arm, multicenter clinical trial, patients received pemetrexed (500 mg/m(2)) and carboplatin (area under the curve=6) intravenously on day 1 every 3 weeks for three to six cycles...
April 2016: Anticancer Research
Dan Lu, Shen Liu, Fangrong Ding, Haiping Wang, Jing Li, Ling Li, Yunping Dai, Ning Li
Human lysozyme is an important natural non-specific immune protein that is highly expressed in breast milk and participates in the immune response of infants against bacterial and viral infections. Considering the medicinal value and market demand for human lysozyme, an animal model for large-scale production of recombinant human lysozyme (rhLZ) is needed. In this study, we generated transgenic cloned cows with the marker-free vector pBAC-hLF-hLZ, which was shown to efficiently express rhLZ in cow milk. Seven transgenic cloned cows, identified by polymerase chain reaction, Southern blot, and western blot analyses, produced rhLZ in milk at concentrations of up to 3149...
2016: Scientific Reports
Vera Margarete Scarpassa, Adrya da Silva Figueiredo, Ronildo Baiatone Alencar
Lutzomyia (Nyssomyia) anduzei has been recognized as a secondary vector of Leishmania guyanensis in the Brazilian Amazon region. Since L. anduzei is anthropophilic, co-exists in areas of high leishmaniasis transmission and has been found infected with L. guyanensis, the understanding of the vector population structure and of the process responsible for it is paramount to the vector management and control efforts. In this study we analyzed 74 and 67 sequences of the COI and Cytb loci, respectively, from mitochondrial DNA, aiming to estimate the intra-population genetic variability and population structure in six L...
April 2015: Infection, Genetics and Evolution
Bernd C Kieseier, Douglas L Arnold, Laura J Balcer, Alexey A Boyko, Jean Pelletier, Shifang Liu, Ying Zhu, Ali Seddighzadeh, Serena Hung, Aaron Deykin, Sarah I Sheikh, Peter A Calabresi
OBJECTIVE: To evaluate the efficacy and safety of subcutaneous peginterferon beta-1a over 2 years in patients with relapsing-remitting multiple sclerosis in the ADVANCE study. METHODS: Patients were randomized to placebo or 125 µg peginterferon beta-1a every 2 or 4 weeks. For Year 2 (Y2), patients originally randomized to placebo were re-randomized to peginterferon beta-1a every 2 weeks or every 4 weeks. Patients randomized to peginterferon beta-1a in Year 1 (Y1) remained on the same dosing regimen in Y2...
July 2015: Multiple Sclerosis: Clinical and Laboratory Research
Fernand A Guédou, Lut Van Damme, Jennifer Deese, Tania Crucitti, Florence Mirembe, Suniti Solomon, Marissa Becker, Michel Alary
OBJECTIVES: Several recent studies suggest that intermediate vaginal flora (IVF) is associated with similar adverse health outcomes as bacterial vaginosis (BV). Yet, it is still unknown if IVF and BV share the same correlates. We conducted a cross-sectional and exploratory analysis of data from women screened prior to enrolment in a microbicide trial to estimate BV and IVF prevalence and examine their respective correlates. METHODS: Participants were interviewed, examined and provided blood and genital samples for the diagnosis of IVF and BV (using Nugent score) and other reproductive tract infections...
March 2014: Sexually Transmitted Infections
Masahiro Ono, Brijen Joshi, Kenneth Brady, R Blaine Easley, Kathy Kibler, John Conte, Ashish Shah, Stuart D Russell, Charles W Hogue
OBJECTIVE: To compare cerebral blood flow (CBF) autoregulation in patients undergoing continuous-flow left ventricular assist device (LVAD) implantation with that in patients undergoing coronary artery bypass grafting (CABG). DESIGN: Prospective, observational, controlled study. SETTING: Academic medical center. PARTICIPANTS: Fifteen patients undergoing LVAD insertion and 10 patients undergoing CABG. MEASUREMENTS AND MAIN RESULTS: Cerebral autoregulation was monitored with transcranial Doppler and near-infrared spectroscopy...
December 2012: Journal of Cardiothoracic and Vascular Anesthesia
Rosa Maria Natalli Montenegro, Eliana Zandonade, Maria Del Carmen Bisi Molina, Lúcia Martins Diniz
Leprosy may present acute/subacute inflammatory processes (leprosy reactions). The study characterized the reactional states of patients at health clinics in Vitória, Espírito Santo State, Brazil, and associated them with sociodemographic factors and clinical/nutritional variables. between January and December 2009, longitudinal follow-up of patients with leprosy continued until leprosy reactions occurred or patients completed 6 months of multidrug therapy. Of the 151 patients participating, 78 (51.7%) were females, 48 (31...
January 2012: Cadernos de Saúde Pública
Satoshi Ishikura, Yoshinori Ito, Masahiro Hiraoka
The Radiation Therapy Study Group (RTSG) of the Japan Clinical Oncology Group (JCOG) was established in 2003. The missions of this group are to develop new standards of care with innovative, advanced technology radiation therapy, both for single- and multi-modality cancer treatment, and to improve radiation therapy quality and outcomes of JCOG trials conducted by other organ-oriented groups. In 2004, the first RTSG trial, a Phase II study of stereotactic body radiation therapy for Stage IA non-small cell lung cancer (JCOG 0403), was initiated...
November 2011: Japanese Journal of Clinical Oncology
Thorben Reinert, Jan Boeckmann, Christian Näther
The asymmetric unit of the title compound, [Zn(NCSe)(2)(C(4)H(4)N(2))(2)], consists of one Zn(II) cation, located on a twofold rotation axis, one seleno-cyanate anion and one pyridazine ligand in general positions. The Zn(II) atom is coordinated by two N-atoms of two pyridazine ligands and two terminal N-bonded seleno-cyanate anions within a slightly distorted tetra-hedral coordination environment. In the crystal, discrete complex mol-ecules are arranged in layers parallel to the ac plane, with Zn(II)⋯Zn(II) distances of 8...
May 1, 2011: Acta Crystallographica. Section E, Structure Reports Online
Jefferson Augusto Santana Ribeiro, André Messias, Ingrid U Scott, Rodrigo Jorge
PURPOSE: To describe an intravitreal injection technique using a commercially available 29-gauge insulin needle syringe (29GN syringe) and a 21-gauge (G) needle, comparing compound waste associated with this technique application and the one described in ranibizumab (Lucentis) kit instructions. METHODS: Ten 0.3 ml doses of distilled water were aspirated using the 29GN syringe and 21G needle (PT technique), and another ten equal doses were aspirated employing the sterilized Lucentis kit (LK technique), which contains a 1ml tuberculin syringe, a 18G needle for compound aspiration and a 30G needle for intravitreal injection...
September 2009: Arquivos Brasileiros de Oftalmologia
Xing-yuan Liu, Yi-qing Yang, Ying Yang, Xiao-ping Lin, Yi-han Chen
OBJECTIVE: The purpose of this investigation was to identify the novel genetic mutations in patients with a congenital atrial septal defect (ASD). METHODS: Clinical data and blood specimens from a total of 12 unrelated ASD pedigrees and a cohort of 168 unrelated subjects with sporadic ASD were collected and evaluated in contrast to 200 healthy individuals. The whole exons and partial flanking introns of NKX2-5 gene were amplified by polymerase chain reaction and sequenced using the di-deoxynucleotide chain termination approach...
September 2009: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
A M Lazaro, Y Xiao, C Masaberg, L Lebeck, J Ng, C K Hurley, P E Posch
Twelve novel human leukocyte antigen class II alleles are described; eight DRB1 alleles and four DQB1 alleles. Nine of the variants are single nucleotide substitutions from their most homologous allele, of which six result in amino acid changes (DRB1*0459, *1156 and *1522; DQB1*0205, *0320 and *0321) and three are silent substitutions (DRB1*030105 and *040304, and DQB1*030104). The remaining alleles (DRB1*0906, *1464 and *1468) differ from their most similar alleles by two to three nucleotide substitutions which alter one to two amino acids...
July 2008: Tissue Antigens
Makoto Ando, Yukihiro Takahashi
BACKGROUND: There is a limitation to the ability of the tricuspid or common atrioventricular valve to function in the systemic position, and insufficiency of these valves often carries an important risk during the staged surgical reconstruction in single ventricle. The purpose of this study was to assess the efficacy of edge-to-edge repair, involving suturing of the free-floating segments of the opposing leaflets, applied in this context. METHODS: Between 1989 and 2006, 49 patients with tricuspid or common atrioventricular valve regurgitation (moderate or greater) associated with single ventricle underwent valve repair 53 times...
November 2007: Annals of Thoracic Surgery
E F Robles, C Sánchez, N Bonnard, M J Delgado, E J Bedmar
Nitrate respiration by the N(2)-fixing symbiotic bacteria Bradyrhizobium japonicum USDA110 is mediated by a Nap (periplasmic nitrate reductase) encoded by the napEDABC genes. Expression of a transcriptional fusion of the nap promoter region to the reporter gene lacZ, P(napE)-lacZ, was very low in aerobically grown cells of USDA110, but expression was induced approx. 3-fold when the cells were cultured under microaerobic conditions, and 12-fold when nitrate was added to the microaerobic incubation medium. The P(napE)-lacZ fusion was not expressed in the fixL 7403, fixJ 7360 and fixK(2) 9043 mutant strains...
February 2006: Biochemical Society Transactions
Rachel S Title, Keith Harper, Erik Nelson, Tom Evans, Richard Tello
OBJECTIVE: The purpose of this study was to evaluate the ability of expert reviewers to differentiate an anemic from a nonanemic state on the basis of visual assessment of the relative attenuation of blood in the left ventricle on noncontrast thoracic CT images and to compare reviewer performance with quantitative measurement of CT density in Hounsfield units. MATERIALS AND METHODS: One hundred two noncontrast thoracic CT examinations were qualitatively reviewed by three independent reviewers...
November 2005: AJR. American Journal of Roentgenology
Grigory S Ryabov, Elena V Kazennova, Marina R Bobkova, Aleksei F Bobkov
Genetic polymorphisms of CCR5, CCR2, and SDF1 genes have been associated with resistance during human immunodeficiency virus type 1 (HIV-1) infection and disease progression. In the present report, we studied the frequency and co-occurrence of CCR5Delta32, CCR5-59029A/G, CCR2-64I, and SDF1-3'A allelic variants among HIV-1-seronegative individuals (n = 171) in Moscow. Observed allelic frequencies were 0.0906 [95% confidence interval (CI), 0.06-0.1212] for CCR5Delta32, 0.4072 (95% CI, 0.3542-0.4602) for CCR5-59029G, 0...
2004: Genetic Testing
Saumen Datta, R N S Rathore, S Vijayalakshmi, Prema G Vasudev, R Balaji Rao, P Balaram, N Shamala
A pentapeptide, Boc-Leu-Ac8c-Ala-Leu-Ac8c-OMe 1, an octapeptide, Boc-Leu-Ac8c-Ala-Leu-Ac8c-Ala-Leu-Ac8c-OMe 2 and a tripeptide, Boc-Aib-Ac8c-Aib-OMe 3 containing the 1-aminocyclooctane-1-carboxylic acid residue (Ac8c) were synthesized and conformationally characterized by x-ray diffraction studies in the crystal state. Peptides 1 and 2 were also studied by NMR in CDC13 solution. Peptide 1 adopts a purely 3(10)-helical conformation in crystals, stabilized by three intramolecular 1 <-- 4 hydrogen bonds. Peptide 2 in crystals is largely 3(10)-helical with distortion in the backbone at the N-terminus by the insertion of a water molecule between Ac8c (2) CO and Ala (6) NH groups...
March 2004: Journal of Peptide Science: An Official Publication of the European Peptide Society
Rebecca R. Conry, William S. Striejewske, A. Alex Tipton
A new macrocyclic ligand with a pendant naphthalene group, N-[2-(1-naphthyl)ethyl]-1-aza-4,8-dithiacyclodecane (L), has been synthesized and characterized. The copper(I)-acetonitrile complex [LCu(CH(3)CN)](PF(6)) (1) was synthesized from L and [Cu(CH(3)CN)(4)](PF(6)). The acetonitrile ligand from 1 was easily removed to give [LCu](PF(6)) (2). Complexes 1 and 2 have been crystallographically characterized. 1: C(21)H(28)N(2)CuF(6)PS(2), triclinic, P&onemacr;, a = 11.1901(10) Å, b = 11.2735(12) Å, c = 12.1350(10) Å, alpha = 98...
June 14, 1999: Inorganic Chemistry
Christian Brückner, Dana L. Caulder, Kenneth N. Raymond
The early literature of catecholate complexes of Ni(II) is explained with regard to both high-spin octahedral and low-spin square-planar complexes. The former contain coordinated solvent, while the latter do not. The syntheses of the paramagnetic (S = 1; &mgr;(eff) = 2.93 &mgr;(B) at 300 K) octahedral Ni(II) complex Na(2)[trans-(H(2)O)(2)(cat)(2)Ni(II)].12H(2)O (1a) and the diamagnetic square-planar Ni(II) complex Na(2)[(cat)(2)Ni(II)].2DMF (2) are described. The physical and chemical properties of these Ni catecholates and their X-ray crystal structures are presented...
December 28, 1998: Inorganic Chemistry
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