Manoj Thapa, Anuradha Kumari, Chui-Yoke Chin, Jacob E Choby, Fengzhi Jin, Bikash Bogati, Daniel M Chopyk, Nitya Koduri, Andrew Pahnke, Elizabeth J Elrod, Eileen M Burd, David S Weiss, Arash Grakoui
The gut-brain axis, a bidirectional signaling network between the intestine and the central nervous system, is crucial to the regulation of host physiology and inflammation. Recent advances suggest a strong correlation between gut dysbiosis and neurological diseases, however, relatively little is known about how gut bacteria impact the brain. Here, we reveal that gut commensal bacteria can translocate directly to the brain when mice are fed an altered diet that causes dysbiosis and intestinal permeability, and that this also occurs without diet alteration in distinct murine models of neurological disease...
September 1, 2023: bioRxiv