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https://www.readbyqxmd.com/read/28432981/hidden-markov-model-and-chapman-kolmogrov-for-protein-structures-prediction-from-images
#1
Md Sarwar Kamal, Linkon Chowdhury, Mohammad Ibrahim Khan, Amira S Ashour, João Manuel R S Tavares, Nilanjan Dey
Protein structure prediction and analysis are more significant for living organs to perfect asses the living organ functionalities. Several protein structure prediction methods use neural network (NN). However, the Hidden Markov model is more interpretable and effective for more biological data analysis compared to the NN. It employs statistical data analysis to enhance the prediction accuracy. The current work proposed a protein prediction approach from protein images based on Hidden Markov Model and Chapman Kolmogrov equation...
April 13, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28432980/discovery-of-potential-inhibitor-against-human-acetylcholinesterase-a-molecular-docking-and-molecular-dynamics-investigation
#2
Surya Pratap Singh, Dwijendra Gupta
Alzheimer's disease (AD) is a progressive neurodegenerative disease of central nervous system among elderly people. Human acetylcholinesterase (hAChE), an important enzyme in neuronal signaling, is responsible for the degradation of acetylcholine which in turn prevents the post synaptic signal transmissions. hAChE has been an attractive target of drug discovery for the search of therapeutics against AD. In the recent past hAChE has become hot target for the investigation of new potential therapeutics. We performed virtual screening of entire database against hAChE...
April 12, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/28432969/quantitative-effects-of-amination-degree-on-the-magnetic-iron-oxide-nanoparticles-mionps-using-as-adsorbents-to-remove-aqueous-heavy-metal-ions
#3
Sen Lin, Meng Xu, Wei Zhang, Xiufu Hua, Kuangfei Lin
The hierarchical effect of amine-functionalization on nanoparticle properties, magnetism especially, and adsorption of Cu(2+), Ni(2+), Pb(2+) and Zn(2+) by aminated MIONPs were investigated elaboratively. The results reflected that the dispersibility and stability of nanoparticles in aqueous solution were both enhanced as MIONPs grafted with amine groups, while saturation magnetism and magnetic recovery conveniences had a negatively correlative relation with the amination degree. In addition, the adsorption performances of Cu(2+), Ni(2+), Pb(2+) and Zn(2+) by different aminated MIONPs were also studied comprehensively...
January 16, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28432935/accelerometry-based-assessment-and-detection-of-early-signs-of-balance-deficits
#4
Heidi Similä, Milla Immonen, Miikka Ermes
Falls are the cause for more than half of the injury-related hospitalizations among older people. Accurate assessment of individuals' fall risk could enable targeted interventions to reduce the risk. This paper presents a novel method for using wearable accelerometers to detect early signs of deficits in balance from gait. Gait acceleration data were analyzed from 35 healthy female participants (73.86±5.40 years). The data were collected with waist-mounted accelerometer and the participants performed three supervised balance tests: Berg Balance Scale (BBS), Timed-Up-and-Go (TUG) and 4m walk...
April 13, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28432830/prevalence-and-risk-factors-of-symptomatic-urinary-tract-infection-after-endoscopic-incision-for-the-treatment-of-ureterocele-in-children
#5
Kimihiko Moriya, Michiko Nakamura, Yoko Nishimura, Yukiko Kanno, Takeya Kitta, Masafumi Kon, Nobuo Shinohara
OBJECTIVE: To clarify the impact of endoscopic incision for ureterocele as an initial procedure, retrospective chart review was performed focusing on the prevalence and risk factors of symptomatic urinary tract infection after endoscopic incision. MATERIALS AND METHODS: Among children with ureterocele who were managed between September 1994 and April 2016, patients who were observed conservatively without additional surgical management after endoscopic incision were included in this study...
April 22, 2017: BJU International
https://www.readbyqxmd.com/read/28432791/immediate-versus-delayed-postpartum-insertion-of-contraceptive-implant-for-contraception
#6
REVIEW
Jen Sothornwit, Yuthapong Werawatakul, Srinaree Kaewrudee, Pisake Lumbiganon, Malinee Laopaiboon
BACKGROUND: The spacing of pregnancies has a positive impact on maternal and newborn health. The progestin contraceptive implant, which is a long-acting, reversible method of contraception, has a well-established low failure rate that is compatible with tubal sterilization. The standard provision of contraceptive methods on the first postpartum visit may put some women at risk of unintended pregnancy, either due to loss to follow-up or having sexual intercourse prior to receiving contraception...
April 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28432784/contributions-of-imprecision-in-pet-mri-rigid-registration-to-imprecision-in-amyloid-pet-suvr-measurements
#7
Christopher G Schwarz, David T Jones, Jeffrey L Gunter, Val J Lowe, Prashanthi Vemuri, Matthew L Senjem, Ronald C Petersen, David S Knopman, Clifford R Jack
Quantitative measurement of β-amyloid from amyloid PET scans typically relies on localizing target and reference regions by image registration to MRI. In this work, we present a series of simulations where 50 small random perturbations of starting location and orientation were applied to each subject's PET scan, and rigid registration using spm_coreg was performed between each perturbed PET scan and its corresponding MRI. We then measured variation in the output PET-MRI registrations and how this variation affected the resulting SUVR measurements...
April 22, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28432727/efficacy-of-fractionated-microneedle-radiofrequency-with-and-without-adding-subcision-for-the-treatment-of-atrophic-facial-acne-scars-a-randomized-split-face-clinical-study
#8
Gita Faghihi, Nazila Poostiyan, Ali Asilian, Bahareh Abtahi-Naeini, Masoom Shahbazi, Fariba Iraji, Farahnaz Fatemi Naeini, Mohammad Ali Nilforoushzadeh
BACKGROUND: There is no gold standard treatment for facial acne scars, and overall, little literature exists about the combination therapy for treatment of acne scar. AIMS: The aim of this study was to evaluate the efficacy of fractionated microneedle radiofrequency (FMR) vs FMR combined with subcision for the treatment of atrophic acne scars. PATIENTS/METHODS: This was a randomized, split-face clinical study of 25 patients with II-IV Fitzpatrick skin types with moderate to severe facial atrophic acne scars...
April 22, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28432676/bifidobacterium-adolescentis-dsm-20083-and-lactobacillus-casei-lafti-l26-dsl-probiotics-able-to-block-the-in-vitro-adherence-of-rotavirus-in-ma104-cells
#9
Karem Prunella Fernandez-Duarte, Nury Nathalia Olaya-Galán, Sandra Patricia Salas-Cárdenas, Jazmin Lopez-Rozo, Maria Fernanda Gutierrez-Fernandez
Rotavirus is the leading worldwide cause of gastroenteritis in children under five years of age. Even though there are some available vaccines to prevent the disease, there are limited strategies for challenging diarrhea induced by rotavirus infection. For this reason, researchers are constantly searching for other approaches to control diarrhea by means of probiotics. In order to demonstrate the ability of some probiotic bacteria to interfere with the in vitro rotavirus infection in MA104 cells, strains of Lactobacillus sp...
April 21, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28432506/elective-colectomy-for-diverticulitis-in-transplant-patients-is-it-worth-the-risk
#10
Janet T Lee, Steve Skube, Genevieve B Melton, Mary R Kwaan, Christine C Jensen, Robert D Madoff, Wolfgang B Gaertner
BACKGROUND: The aim of this study was to determine morbidity and mortality for transplant patients undergoing elective colectomy for diverticulitis and determine the impact of recurrent diverticulitis on postoperative complications. METHODS: We identified transplant recipients that underwent elective colectomy for diverticulitis between 2000 and 2015 at a tertiary care institution. Patient and procedure variables, postoperative complications, length of stay, 30-day readmission, and mortality were identified through retrospective chart review...
April 21, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28432387/yttrium-90-radioembolization-for-unresectable-combined-hepatocellular-cholangiocarcinoma
#11
Lauren S Chan, Daniel Y Sze, George A Poultsides, John D Louie, Mohammed A Abdelrazek Mohammed, David S Wang
PURPOSE: Combined hepatocellular-cholangiocarcinoma (cHCC-CC) is a rare mixed cell type primary liver cancer with limited data to guide management. Transarterial radioembolization with yttrium-90 microspheres (RE) is an emerging treatment option for both hepatocellular carcinoma and intrahepatic cholangiocarcinoma. This study explored the safety and efficacy of RE for unresectable cHCC-CC. METHODS: Patients with histopathologically confirmed cHCC-CC treated with RE were retrospectively evaluated...
April 21, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28432023/pulmonary-embolism-related-sudden-cardiac-arrest-admitted-alive-at-hospital-management-and-outcomes
#12
Wulfran Bougouin, Eloi Marijon, Benjamin Planquette, Nicole Karam, Florence Dumas, David S Celermajer, Daniel Jost, Lionel Lamhaut, Frankie Beganton, Alain Cariou, Guy Meyer, Xavier Jouven
AIM: Pulmonary Embolism (PE) is a relatively common cardiovascular condition, occasionally and tragically manifesting as Sudden Cardiac Arrest (SCA). The natural history of SCA complicating PE has been poorly evaluated.In this study, we described the management and outcome of PE-related SCA. METHODS: In this prospective population-based study, we included all patients admitted at hospital alive after out-of- hospital SCA, in Paris and suburbs, France (6.6 million inhabits), from May 2011 to September 2015...
April 18, 2017: Resuscitation
https://www.readbyqxmd.com/read/28431862/application-of-the-cdc-ebolaresponse-modeling-tool-to-disease-predictions
#13
Robert H Gaffey, Cécile Viboud
Model-based predictions were critical in eliciting a vigorous international public health response to the 2014 Ebola Virus Disease outbreak in West Africa. Here, we describe the performances of an extension of the CDC-initiated EbolaResponse Modeling tool to the Ebola Forecasting Challenge, which offered a controlled environment for epidemiological predictions. In the EbolaResponse tool, transmission risks and proportions of population affected by interventions were fitted to data via least square fitting. Prediction performances were evaluated for 5 prediction time points of 4 synthetic outbreaks...
March 10, 2017: Epidemics
https://www.readbyqxmd.com/read/28431740/getting-a-grip-on-reality-grasping-movements-directed-to-real-objects-and-images-rely-on-dissociable-neural-representations
#14
Erez Freud, Scott N Macdonald, Juan Chen, Derek J Quinlan, Melvyn A Goodale, Jody C Culham
In the current era of touchscreen technology, humans commonly execute visually guided actions directed to two-dimensional (2D) images of objects. Although real, three-dimensional (3D), objects and images of the same objects share high degree of visual similarity, they differ fundamentally in the actions that can be performed on them. Indeed, previous behavioral studies have suggested that simulated grasping of images relies on different representations than actual grasping of real 3D objects. Yet the neural underpinnings of this phenomena have not been investigated...
March 18, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28431693/the-society-of-thoracic-surgeons-general-thoracic-surgery-database-2017-update-on-outcomes-and-quality
#15
Christopher W Seder, Daniel P Raymond, Cameron D Wright, Henning A Gaissert, Andrew C Chang, Sydney Clinton, Susan Becker, Felix G Fernandez, Benjamin D Kozower
The Society of Thoracic Surgeons General Thoracic Surgery Database (STS GTSD) is a voluntary effort that provides participants with risk-adjusted semiannual performance reports that allow comparison of institutional outcomes against national benchmarks. With nearly 1,000 surgeons contributing data from more than 300 centers across North America, the STS GTSD now includes almost a half million cases. In 2016, updated risk models for lung resection and esophagectomy for cancer were reported, and composite quality measures for lobectomy and esophagectomy were developed...
May 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28431589/t2-relaxometry-helps-prognosticate-seizure-outcome-in-patients-with-solitary-cerebral-cysticercosis
#16
Aaron de Souza, Atchayaram Nalini, Jitender Saini, Kandavel Thennarasu
OBJECTIVE: Correlate serial T2 relaxometry (T2R) values with long term seizure outcome in patients with solitary cerebral cysticercosis (SCC) in order to establish its usefulness as a prognostic marker in these patients. METHODS: Patients with new-onset seizures due to SCC were imaged serially using a pre-determined MRI protocol at enrolment and after 3, 6, 12 and 24months. T2 relaxometry was performed using a dual echo sequence with maps generated manually from the measured image intensities at the level of the lesion...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28431274/distribution-of-escherichia-coli-o157-h7-in-ground-beef-assessing-the-clustering-intensity-for-an-industrial-scale-grinder-and-a-low-and-localized-initial-contamination
#17
Estelle Loukiadis, Clémence Bièche-Terrier, Catherine Malayrat, Franck Ferré, Philippe Cartier, Jean-Christophe Augustin
Undercooked ground beef is regularly implicated in food-borne outbreaks involving pathogenic Shiga toxin-producing Escherichia coli. The dispersion of bacteria during mixing processes is of major concern for quantitative microbiological risk assessment since clustering will influence the number of bacteria the consumers might get exposed to as well as the performance of sampling plans used to detect contaminated ground beef batches. In this study, batches of 25kg of ground beef were manufactured according to a process mimicking an industrial-scale grinding with three successive steps: primary grinding, mixing and final grinding...
March 18, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28430821/dietary-dha-epa-ratio-affected-tissue-fatty-acid-profiles-antioxidant-capacity-hematological-characteristics-and-expression-of-lipid-related-genes-but-not-growth-in-juvenile-black-seabream-acanthopagrus-schlegelii
#18
Min Jin, Óscar Monroig, You Lu, Ye Yuan, Yi Li, Liyun Ding, Douglas R Tocher, Qicun Zhou
An 8-week feeding trial was conducted to investigate the effects of dietary docosahexaenoic to eicosapentaenoic acid ratio (DHA/EPA) on growth performance, fatty acid profiles, antioxidant capacity, hematological characteristics and expression of some lipid metabolism related genes of juvenile black seabream (Acanthopagrus schlegelii) of initial weight 9.47 ± 0.03 g. Five isonitrogenous and isolipidic diets (45% crude protein and 14% crude lipid) were formulated to contain graded DHA/EPA ratios of 0.65, 1...
2017: PloS One
https://www.readbyqxmd.com/read/28430726/vaginal-mesh-removal-outcomes-eight-years-of-experience-at-an-academic-hospital
#19
Olivia O Cardenas-Trowers, Pouran Malekzadeh, David E Nix, Kenneth D Hatch
OBJECTIVES: The purpose of this study is to describe the clinical history leading up to and the outcomes after vaginal mesh removal surgery at an academic hospital. METHODS: A retrospective case series of patients who underwent vaginal mesh removal from 2008 to 2015 was conducted. Demographics, clinical history, physical examination, pre- and postoperative symptoms, and number and type of reoperations were abstracted. RESULTS: Between February 2008 and November 2015, 83 patients underwent vaginal mesh removal surgery at our hospital...
April 20, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28430669/low-previous-cardiovascular-risk-of-patients-with-st-elevation-myocardial-infarction
#20
Gustavo Rodrigues, Pedro de Araújo Gonçalves, Francisco Moscoso Costa, Rui Campante Teles, Dores Hélder, Luís Mariano, João Brito, Henrique Mesquita Gabriel, Manuel Almeida, Miguel Mendes
BACKGROUND: Myocardial infarction is frequently the initial form of presentation of coronary artery disease (CAD). Systemic Coronary Risk Estimation (SCORE) risk tables are used in primary prevention and provide an estimate of cardiovascular (CV) risk through known risk factors. The aim of this study was to evaluate the performance of the SCORE, calculated using data previous to the event, to estimate CV risk of a population of patients presenting with ST-elevation myocardial infarction (STEMI) as the first manifestation of CAD...
April 20, 2017: Coronary Artery Disease
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