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https://www.readbyqxmd.com/read/28927091/clinical-and-biological-effects-of-tumor-associated-lymphocytes-in-the-presence-or-absence-of-chemotherapy-for-malignant-ascites-in-ovarian-cancer-patients
#1
Weiwei Zhang, Kejun Liu, Bin Ye, Guolin Hu, Kelei Zhao, Yazhou Ren, Weijiang Liang
Tumor-associated lymphocytes (TALs) have been successfully isolated from ascites and solid tumors, however the clinical use of TALs in treating ovarian cancer (OC) has not yet been reported. The present study investigated the efficacy and toxicity of TALs in the presence or absence of chemotherapy in OC patients with malignant ascites (MA). A total of 32 patients were enrolled in this study. A total of 8 patients received treatment with TALs alone (TALs group), 11 patients received combined treatment of TALs and chemotherapy (combination group) and 13 patients received chemotherapy alone (chemotherapy group)...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926818/effects-of-genetically-modified-cotton-stalks-on-antibiotic-resistance-genes-inti1-and-inti2-during-pig-manure-composting
#2
Manli Duan, Jie Gu, Xiaojuan Wang, Yang Li, Sheqi Zhang, Yanan Yin, Ranran Zhang
Genetically modified (GM) cotton production generates a large yield of stalks and their disposal is difficult. In order to study the feasibility of using GM cotton stalks for composting and the changes that occur in antibiotic resistance genes (ARGs) during composting, we supplemented pig manure with GM or non-GM cotton stalks during composting and we compared their effects on the absolute abundances (AA) of intI1, intI2, and ARGs under the two treatments. The compost was mature after processing based on the germination index and C/N ratio...
September 16, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28925199/are-stipulated-requirements-for-the-quality-of-maternity-care-complied-with
#3
Lars T Johansen, Aase Serine Devold Pay, Lise Broen, Brit Roland, Pål Øian
No abstract text is available yet for this article.
September 18, 2017: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/28923419/tumor-associated-macrophages-are-strongly-related-to-vascular-invasion-non-luminal-subtypes-and-interval-breast-cancer
#4
Tor A Klingen, Ying Chen, Hans Aas, Elisabeth Wik, Lars A Akslen
Tumor associated macrophages (TAM) resemble M2 macrophages, promote tumor invasion and show strong expression of CD163 in breast cancer. We here investigated the association between CD163 positive macrophages and vascular invasion, molecular subgroups, mode of detection, and patient outcome. We performed a population-based, retrospective study of invasive breast cancer from the Norwegian Breast Cancer Screening Programme in Vestfold County (2004-2009), including 200 screen-detected and 82 interval cancers. Immunohistochemically CD163 positive macrophages were counted in the most active areas (hot-spots) and dichotomized as high (upper quartile) and low counts...
September 15, 2017: Human Pathology
https://www.readbyqxmd.com/read/28919843/the-effects-of-phenylalanine-on-exercise-induced-fat-oxidation-a-preliminary-double-blind-placebo-controlled-crossover-trial
#5
Keisuke Ueda, Chiaki Sanbongi, Makoto Yamaguchi, Shuji Ikegami, Takafumi Hamaoka, Satoshi Fujita
BACKGROUND: When combined with exercise, dietary amino acid (AA) supplementation is an effective method for accelerating fat mobilization. However, the effects of single AAs combined with exercise on fat oxidation remains unclear. We hypothesized that consumption of a specific amino acid, L- phenylalanine, may result in the secretion of glucagon, and when combined with exercise may promote fat oxidation. METHODS: Six healthy, active male volunteers were randomized in a crossover study to ingest either phenylalanine (3 g/dose) or placebo...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28918961/remembrances-from-an-early-follower-and-leader-of-the-association-for-academic-surgery
#6
Hiram C Polk
This reflection retraces the evolution of early followers and leaders. Social change and early contributions set the stage for the current Association for Academic Surgery. Perhaps the most important contribution was Dr. George Zuidema's theme of inclusiveness. AAS was a decade ahead of its time in that regard.
September 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28918958/the-association-for-academic-surgery-2011-present-standing-on-the-shoulders-of-giants
#7
Allison L Speer, Lillian S Kao
The Association for Academic Surgery (AAS), which is a society dedicated to inspiring and developing young academic surgeons, recently celebrated its 50th anniversary. Each decade since its inception has seen incredible growth. This most recent decade, from 2011 to present, has been characterized by: (1) reevaluation and clarification of the society's vision, mission, core values and organizational structure; (2) diversification of the membership and leadership; (3) support for international outreach and global surgery research; (4) expansion of its impact through social media; and (5) adaptability to a changing political climate...
September 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28918957/introduction-to-the-2017-founders-lecture-of-the-association-for-academic-surgery
#8
Francis Charles Brunicardi, Mitra Jamshidian
This year's Founders' Lecture will focus on the founding and history of the Association for Academic Surgery (AAS), as presented by five past presidents. The lecture will give the readers a unique and condensed perspective on the remarkable history of the AAS. The AAS was founded in 1967 by Dr George Zuidema with the mission to offer young academic surgeons an inclusive forum for discussion about surgical research and the opportunity for professional growth.1 Since its establishment in 1966, with a membership of only 33 people,1the organization has grown into a diverse international organization with over 2800 members...
September 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28918629/dosimetric-quantification-of-coating-related-uptake-of-silver-nanoparticles
#9
Dajana Lichtenstein, Thomas Meyer, Linda Böhmert, Sabine Juling, Christoph Fahrenson, Soeren Selve, Andreas F Thünemann, Jan Meijer, Irina Estrela-Lopis, Albert Braeuning, Alfonso Lampen
The elucidation of mechanisms underlying cellular uptake of nanoparticles is an important topic in nanotoxicological research. Most studies dealing with silver nanoparticle uptake provide only qualitative data about internalization efficiency and do not consider nanoparticle-specific dosimetry. Therefore, we performed a comprehensive comparison of the cellular uptake of differently coated silver nanoparticles of comparable size in different human intestinal Caco-2 cell-derived models to cover also the influence of the intestinal mucus barrier and uptake-specialized M-cells...
September 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28913727/sleep-amount-differentially-affects-fear-processing-neural-circuitry-in-pediatric-anxiety-a-preliminary-fmri-investigation
#10
Christina O Carlisi, Kevin Hilbert, Amanda E Guyer, Monique Ernst
Insufficient sleep, as well as the incidence of anxiety disorders, both peak during adolescence. While both conditions present perturbations in fear-processing-related neurocircuitry, it is unknown whether these neurofunctional alterations directly link anxiety and compromised sleep in adolescents. Fourteen anxious adolescents (AAs) and 19 healthy adolescents (HAs) were compared on a measure of sleep amount and neural responses to negatively valenced faces during fMRI. Group differences in neural response to negative faces emerged in the dorsal anterior cingulate cortex (dACC) and the hippocampus...
September 14, 2017: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/28912365/d-dimer-in-african-americans-whole-genome-sequence-analysis-and-relationship-to-cardiovascular-disease-risk-in-the-jackson-heart-study
#11
Laura M Raffield, Neil A Zakai, Qing Duan, Cecelia Laurie, Joshua D Smith, Marguerite R Irvin, Margaret F Doyle, Rakhi P Naik, Ci Song, Ani W Manichaikul, Yongmei Liu, Peter Durda, Jerome I Rotter, Nancy S Jenny, Stephen S Rich, James G Wilson, Andrew D Johnson, Adolfo Correa, Yun Li, Deborah A Nickerson, Kenneth Rice, Ethan M Lange, Mary Cushman, Leslie A Lange, Alex P Reiner
OBJECTIVE: Plasma levels of the fibrinogen degradation product D-dimer are higher among African Americans (AAs) compared with those of European ancestry and higher among women compared with men. Among AAs, little is known of the genetic architecture of D-dimer or the relationship of D-dimer to incident cardiovascular disease. APPROACH AND RESULTS: We measured baseline D-dimer in 4163 AAs aged 21 to 93 years from the prospective JHS (Jackson Heart Study) cohort and assessed association with incident cardiovascular disease events...
September 14, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28911778/applications-of-isotope-ratio-mass-spectrometry-in-sports-drug-testing-accounting-for-isotope-fractionation-in-analysis-of-biological-samples
#12
Thomas Piper, Mario Thevis
The misuse of anabolic-androgenic steroids (AAS) in sports aiming at enhancing athletic performance has been a challenging matter for doping control laboratories for decades. While the presence of a xenobiotic AAS or its metabolite(s) in human urine immediately represents an antidoping rule violation, the detection of the misuse of endogenous steroids such as testosterone necessitates comparably complex procedures. Concentration thresholds and diagnostic analyte ratios computed from urinary steroid concentrations of, e...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28902062/african-american-hemodialysis-patients-perceptions-of-faith-and-nursing
#13
Elizabeth Seaton Nix
Numerous quantitative studies have been conducted with African Americans (AAs) receiving hemodialysis. This article shares a portion of a larger qualitative study that explored the role spirituality plays in the lives of AAs undergoing hemodialysis for management of end-stage renal disease (ESRD). Interview questions centered on the roles of spirituality, health beliefs, and different social support systems used in coping. By understanding the perceptions of AAs with ESRD, nurses and other providers can offer better support...
October 2017: Journal of Christian Nursing: a Quarterly Publication of Nurses Christian Fellowship
https://www.readbyqxmd.com/read/28901783/quantification-of-manganese-and-mercury-in-toenail-in-vivo-using-portable-x-ray-fluorescence-xrf
#14
Xinxin Zhang, Aaron J Specht, Linda H Nie
BACKGROUND AND OBJECTIVE: Toenail is an advantageous biomarker to assess exposure to metals such as manganese and mercury. Toenail Mn and Hg are in general analyzed by chemical methods such as ICP-MS and AAS. In this project, a practical and convenient technology - portable x-ray florescence (XRF) - is studied for the non-invasive in vivo quantification of manganese and mercury in toenail. MATERIALS AND METHODS: The portable XRF method has advantages in that it does not require toenail clipping and it can be done in 3 minutes, which will greatly benefit human studies involving the assessment of manganese and mercury exposures...
September 13, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28899209/microneedle-mediated-transdermal-delivery-of-nanostructured-lipid-carriers-for-alkaloids-from-aconitum-sinomontanum
#15
Teng Guo, Yongtai Zhang, Zhe Li, Jihui Zhao, Nianping Feng
A combination method using microneedle (MN) pretreatment and nanostructured lipid carriers (NLCs) was developed to improve the transdermal delivery of therapeutics. The MN treatment of the skin and co-administration of NLCs loaded with total alkaloids isolated from Aconitum sinomontanum (AAS-NLCs) significantly increased the skin permeation of the drugs. Fluorescence imaging confirmed that MNs could provide microchannels penetrating the stratum corneum, and delivery of NLCs through the channels led to their deeper permeation...
September 12, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28898389/racial-differences-in-the-association-between-apolipoprotein-e-risk-alleles-and-overall-and-total-cardiovascular-mortality-over-18%C3%A2-years
#16
Kumar B Rajan, Lisa L Barnes, Robert S Wilson, Elizabeth A McAninch, Jennifer Weuve, Dominique Sighoko, Denis A Evans
OBJECTIVES: To examine the difference in the association between apolipoprotein (APO)E allele and overall and cardiovascular mortality between African Americans (AAs) and European Americans (EAs). DESIGN: Longitudinal, cohort study of 18 years. SETTING: Biracial urban US population sample. PARTICIPANTS: 4,917, 68% AA and 32% EA. MEASUREMENTS: APOE genotype and mortality based on National Death Index...
September 12, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28895046/characterization-of-cadmium-resistant-klebsiella-pneumoniae-mcc-3091-promoted-rice-seedling-growth-by-alleviating-phytotoxicity-of-cadmium
#17
Krishnendu Pramanik, Soumik Mitra, Anumita Sarkar, Tithi Soren, Tushar Kanti Maiti
Cadmium (Cd) phytotoxicity in agricultural land is a major global concern now-a-days resulting in very poor yield. Plant growth-promoting rhizobacteria (PGPR)-mediated bioremediation is one of the convenient strategies for detoxification of Cd from the soil and for plant growth promotion under Cd stress. The selected strain K5 was identified as Klebsiella pneumoniae based on MALDI-TOF MS ribosomal protein and 16S rDNA sequence-based homology. The strain possessed several PGP traits viz. IAA production (3413 μg/mL), phosphate solubilization (80...
September 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28894712/evaluation-of-the-level-of-zinc-and-malondialdehyde-in-basal-cell-carcinoma
#18
Ziba Majidi, Mahmoud Djalali, Mohammad Hasan Javanbakht, Mojtaba Fathi, Mahnaz Zarei, Koorosh Foladsaz
BACKGROUND: Basal Cell Carcinoma (BCC) is one of the most common skin cancers in the world and that use to lifestyle, increasing chemical pollutions, environmental factors and poor nutrition. The most important cause of this cancer is oxidative stress and free radicals so antioxidant activities for the body are so important. The aim of this study was to determine the variation of zinc and (Malondialdehyde) MDA in BCC patients. METHODS: This study has been performed on case and control patients from 2013 to 2014...
August 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28891713/effect-of-preoperative-deformity-on-arthroscopic-and-open-ankle-fusion-outcomes
#19
Timo Schmid, Fabian Krause, Murray J Penner, Andrea Veljkovic, Alastair S E Younger, Kevin Wing
INTRODUCTION: Coronal deformity is considered a relative contraindication for arthroscopic ankle fusion. This study assessed whether preoperative coronal ankle joint deformity influenced the outcome of arthroscopic ankle fusion. METHODS: Ninety-seven patients had 62 arthroscopic and 35 open ankle fusions between 2005 and 2012. Clinical outcomes were prospectively recorded with use of the Ankle Osteoarthritis Scale (AOS) and Ankle Arthritis Scale (AAS) preoperatively and at 6, 12, and 24 months and final follow-up...
September 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28886076/lower-frequency-of-tlr9-variant-associated-with-protection-from-breast-cancer-among-african-americans
#20
Madison R Chandler, Kimberly S Keene, Johanna M Tuomela, Andres Forero-Torres, Renee Desmond, Katri S Vuopala, Kevin W Harris, Nancy D Merner, Katri S Selander
INTRODUCTION: Toll-like receptor 9 (TLR9) is an innate immune system DNA-receptor that regulates tumor invasion and immunity in vitro. Low tumor TLR9 expression has been associated with poor survival in Caucasian patients with triple negative breast cancer (TNBC). African American (AA) patients with TNBC have worse prognosis than Caucasians but whether this is due to differences in tumor biology remains controversial. We studied the prognostic significance of tumor Toll like receptor-9 (TLR9) protein expression among African American (AA) triple negative breast cancer (TNBC) patients...
2017: PloS One
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