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https://www.readbyqxmd.com/read/29338330/joint-influence-of-snps-and-dna-methylation-on-lipids-in-african-americans-from-hypertensive-sibships
#1
Michelle L Wright, Erin B Ware, Jennifer A Smith, Sharon L R Kardia, Jacquelyn Y Taylor
INTRODUCTION: Plasma concentrations of lipids (i.e., total cholesterol, high-density cholesterol, low-density cholesterol, and triglycerides) are amenable to therapeutic intervention and remain important factors for assessing risk of cardiovascular diseases. Some of the observed variability in serum lipid concentrations has been associated with genetic and epigenetic variants among cohorts with European ancestry (EA). Serum lipid levels have also been associated with genetic variants in multiethnic populations...
January 1, 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29337321/synthesis-spectroscopic-investigation-and-dft-study-of-n-n-disubstituted-ferrocene-based-thiourea-complexes-as-potent-anticancer-agents
#2
Faiza Asghar, Saira Fatima, Sadaf Rana, Amin Badshah, Ian S Butler, Muhammad Nawaz Tahir
In the present work, the synthesis, characterization (FT-IR, multinuclear (1H and 13C) NMR, AAS, Raman, and elemental analyses), DNA binding (cyclic voltammetry, UV-Vis spectroscopy), and in vitro biological screening of nine new ferrocene-incorporated thioureas (A1-A9) are reported. Furthermore, the single-crystal X-ray structure of compound A8 was also determined. The ferrocene-based N,N'-disubstituted thioureas were derived by allowing the ferrocenyl anilines to react with freshly prepared isothiocyanates under a N2 atmosphere in dry acetone...
January 16, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29335189/biofuel-production-and-phycoremediation-by-chlorella-sp-istla1-isolated-from-landfill-site
#3
Arti Mishra, Kristina Medhi, Neha Maheshwari, Shaili Srivastava, Indu Shekhar Thakur
The present study aims to investigate the biofuel production ability and potential of heavy metal remediation of Chlorella sp. ISTLA1 isolated from a landfill site. The strain was cultured in Bold's Basal medium at different concentration of NaHCO3 and pH. Response surface methodology was employed for the optimization of nutrient sources for higher lipid production. Under the optimized conditions, the yield of lipid and biomass was 365.42 and 833.14 mg L-1 respectively. GC-MS analysis of lipid indicated the presence of C8 to C31 organic compounds consisting mainly of palmitic acid (C16:0), stearic acid (C18:0) and oleic acid (C18:1)...
January 6, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29333632/binding-of-cu-and-cu2-with-peptides-peptides-oxytocin-arg8-vasopressin-bradykinin-angiotensin-i-substance-p-somatostatin-and-neurotensin
#4
Thankan Jayasekharan, Shyam L Gupta, Vikas Dhiman
The intrinsic binding ability of seven natural peptides (oxytocin, arg8 -vasopressin, bradykinin, angiotensin-I, substance-P, somatostatin, and neurotensin) with copper in two different oxidation states (CuI/II ) derived from different Cu+/2+ precursor sources have been investigated for their charge dependent binding characteristics. The peptide-CuI/II complexes, [M - (n-1)H + nCuI ] and [M - (2n-1)H + nCuII ] are prepared/generated by the reaction of peptides with CuI solution/Cu-target and CuSO4 solution, and are analyzed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS)...
January 15, 2018: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29333102/an-amino-acids-mixture-attenuates-glycemic-impairment-but-not-affects-adiposity-development-in-rats-fed-with-ages-containing-diet
#5
Yi-Hung Liao, Chung-Yu Chen, Chiao-Nan Chen, Chia-Ying Wu, Shiow-Chwen Tsai
Background: Unhealthy western dietary patterns lead to over-consumption of fat and advanced glycation end-products (AGEs), and these account for the developments of obesity, diabetes, and related metabolic disorders. Certain amino acids (AAs) have been recently demonstrated to improve glycemia and reduce adiposity. Therefore, our primary aims were to examine whether feeding an isoleucine-enriched AA mixture (4.5% AAs; Ile: 3.0%, Leu: 1.0%, Val: 0.2%, Arg: 0.3% in the drinking water) would affect adiposity development and prevent the impairments of glycemic control in rats fed with the fat/AGE-containing diet (FAD)...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29329416/automatic-ecg-based-detection-of-autonomic-arousals-and-their-association-with-cortical-arousals-leg-movements-and-respiratory-events-in-sleep
#6
Mads Olsen, Logan Douglas Schneider, Joseph Cheung, Paul E Peppard, Poul J Jennum, Emmanuel Mignot, Helge Bjarup Dissing Sorensen
Study objectives: The current definition of sleep arousals neglects to address the diversity of arousals and their systemic cohesion. Autonomic arousals (AA) are autonomic activations often associated with cortical arousals (CA), but they may also occur in isolation in relation to a respiratory event, a leg movement event or spontaneously, without any other physiological associations. AA should be acknowledged as essential events to understand and explore the systemic implications of arousals...
January 10, 2018: Sleep
https://www.readbyqxmd.com/read/29326280/autoantibodies-against-angiotensin-and-adrenergic-receptors-more-than-a-biomarker
#7
Rugina Neuman, A H Jan Danser
Agonistic autoantibodies (AAs) directed against receptors of the sympathetic nervous system and the renin-angiotensin system have been suggested to contribute to cardiovascular and renal disease, in particular hypertension, preeclampsia, and graft failure in kidney transplantation patients. Consequently, they are now also being studied as biomarker for these conditions. This commentary summarizes our current understanding of these AAs, critically discussing whether they truly act as agonist, and focusing on the wide array of assays that are currently used for their quantification...
January 16, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29323774/obesity-impairs-oligopeptide-amino-acid-induced-ghrelin-release-and-smooth-muscle-contractions-in-the-human-proximal-stomach
#8
L Vancleef, T Thijs, F Baert, L J Ceulemans, E Canovai, Q Wang, S Steensels, A Segers, R Farré, J Pirenne, M Lannoo, J Tack, I Depoortere
SCOPE: The satiation properties of proteins involve effects on gut peptide release and gastrointestinal motility which may be altered during obesity. This study compared the in vitro response and role of amino acid (AA) taste receptors (TASR) in the effect of AAs and a casein hydrolysate on ghrelin release and smooth muscle (SM) contractions in the proximal gut of lean and obese patients. METHODS AND RESULTS: Basal ghrelin release, measured from mucosal segments, was maximal in the fundus and decreased distally...
January 11, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29322001/evaluation-of-the-antidiabetic-property-of-aqueous-leaves-extract-of%C3%A2-zanthoxylum-armatum-dc-using-in%C3%A2-vivo-and-in%C3%A2-vitro-approaches
#9
Carey Vana Rynjah, Ningthoujam Neelima Devi, Nasheman Khongthaw, Donkupar Syiem, Suktilang Majaw
The present study was designed to evaluate the antidiabetic potential of the aqueous leaves extract of Zanthoxylum armatum DC. leaves using in vivo and in vitro approaches. For in vivo studies, blood glucose level was monitored at different intervals after administration of varying doses of the extract for its hypoglycemic (100-6000 mg/kg b.w.) and antihyperglycemic (250 mg/kg b.w.) effect in normoglycemic and diabetic mice. In vitro enzymatic inhibition activity was tested against α-amylase, α- and β-glucosidase and lipase...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29321517/genome-wide-association-study-of-homocysteine-in-african-americans-from-the-jackson-heart-study-the-multi-ethnic-study-of-atherosclerosis-and-the-coronary-artery-risk-in-young-adults-study
#10
Laura M Raffield, Jaclyn Ellis, Nels C Olson, Qing Duan, Jin Li, Peter Durda, Nathan Pankratz, Brendan J Keating, Christina L Wassel, Mary Cushman, James G Wilson, Myron D Gross, Russell P Tracy, Stephen S Rich, Alex P Reiner, Yun Li, Monte S Willis, Ethan M Lange, Leslie A Lange
Homocysteine (Hcy) is a heritable biomarker for CVD, peripheral artery disease, stroke, and dementia. Little is known about genetic associations with Hcy in individuals of African ancestry. We performed a genome-wide association study for Hcy in 4927 AAs from the Jackson Heart Study (JHS), the Multi-Ethnic Study of Atherosclerosis (MESA), and the Coronary Artery Risk in Young Adults (CARDIA) study. Analyses were stratified by sex and results were meta-analyzed within and across sex. In the sex-combined meta-analysis, we observed genome-wide significant evidence (p < 5...
January 10, 2018: Journal of Human Genetics
https://www.readbyqxmd.com/read/29321463/use-of-a-smartphone-as-a-colorimetric-analyzer-in-paper-based-devices-for-sensitive-and-selective-determination-of-mercury-in-water-samples
#11
Purim Jarujamrus, Rattapol Meelapsom, Somkid Pencharee, Apinya Obma, Maliwan Amatatongchai, Nadh Ditcharoen, Sanoe Chairam, Suparb Tamuang
A smartphone application, called CAnal, was developed as a colorimetric analyzer in paper-based devices for sensitive and selective determination of mercury(II) in water samples. Measurement on the double layer of a microfluidic paper-based analytical device (μPAD) fabricated by alkyl ketene dimer (AKD)-inkjet printing technique with special design doped with unmodified silver nanoparticles (AgNPs) onto the detection zones was performed by monitoring the gray intensity in the blue channel of AgNPs, which disintegrated when exposed to mercury(II) on μPAD...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29321262/nonsensing-residues-in-s3-s4-linker-s-c-terminus-affect-the-voltage-sensor-set-point-in-k-channels
#12
Joao L Carvalho-de-Souza, Francisco Bezanilla
Voltage sensitivity in ion channels is a function of highly conserved arginine residues in their voltage-sensing domains (VSDs), but this conservation does not explain the diversity in voltage dependence among different K+ channels. Here we study the non-voltage-sensing residues 353 to 361 in Shaker K+ channels and find that residues 358 and 361 strongly modulate the voltage dependence of the channel. We mutate these two residues into all possible remaining amino acids (AAs) and obtain Q-V and G-V curves. We introduced the nonconducting W434F mutation to record sensing currents in all mutants except L361R, which requires K+ depletion because it is affected by W434F...
January 10, 2018: Journal of General Physiology
https://www.readbyqxmd.com/read/29318080/race-and-rehabilitation-destination-after-elective-total-hip-arthroplasty-analysis-of-a-large-regional-data-set
#13
Ernest R Vina, Michael J Kallan, Aliya Collier, Charles L Nelson, Said A Ibrahim
Background: Three-quarters of patients who undergo total hip replacement (THR) receive postsurgical rehabilitation care in an inpatient rehabilitation facility (IRF), a skilled nursing facility (SNF), or through a home health agency. The objectives of this study are to examine racial differences where THR recipients receive postsurgical rehabilitation care and determine whether discharge destination is associated with hospital readmission. Methods: Using the Pennsylvania Health Care Cost Containment Council database, we selected African American (AA) or white adults who underwent THR surgery (n = 68,016)...
December 2017: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/29317256/nandrolone-combined-with-strenuous-resistance-training-reduces-vascular-nitric-oxide-bioavailability-and-impairs-endothelium-dependent-vasodilation
#14
Vinicius Guzzoni, Tatiana Sousa Cunha, Vander José das Neves, Larissa Briet, Rafaela Costa, Maria José Costa Sampaio Moura, Vanessa Oliveira, Maria do Carmo Pinho Franco, Pedro Duarte Novaes, Fernanda Klein Marcondes
Anabolic Androgenic Steroids (AASs) misuse has increased among adolescents and recreational athletes due to their potential effects on muscle hypertrophy. On the other hand, AAS might induce alterations on cardiovascular system, although some controversies regarding AAS on vascular properties remain unknown. To address this question, we aimed to investigate the effects of high doses of nandrolone combined with strenuous resistance training (RT) on function and structure of thoracic aorta. Rats were randomized into four groups: non-trained vehicle (NTV), trained vehicle (TV), non-trained nandrolone (NTN), and trained nandrolone (TN), and submitted to 6 weeks of treatment with nandrolone (5mg/kg, twice a week) and/or resistance training...
January 6, 2018: Steroids
https://www.readbyqxmd.com/read/29313872/validation-of-the-early-functional-abilities-scale-an-assessment-of-four-dimensions-in-early-recovery-after-traumatic-brain-injury
#15
Ingrid Poulsen, Svend Kreiner, Aase W Engberg
OBJECTIVE: The Early Functional Abilities scale assesses the restoration of brain function after brain injury, based on 4 dimensions. The primary objective of this study was to evaluate the validity, objectivity, reliability and measurement precision of the Early Functional Abilities scale by Rasch model item analysis. A secondary objective was to examine the relationship between the Early Functional Abilities scale and the Functional Independence Measurement™, in order to establish the criterion validity of the Early Functional Abilities scale and to compare the sensitivity of measurements using the 2 instruments...
January 9, 2018: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29313298/dimensions-of-and-responses-to-perceived-discrimination-and-subclinical-disease-among-african-americans-in-the-jackson-heart-study
#16
Victoria I Okhomina, LáShauntá Glover, Herman Taylor, Mario Sims
BACKGROUND: Although discrimination among African Americans (AAs) has been linked to various health outcomes, few studies have examined associations of multiple measures of discrimination with prevalent subclinical disease in a large sample of AAs. OBJECTIVES: To examine the associations of measures of discrimination and coping responses to discrimination with prevalent subclinical disease among AAs in the Jackson Heart Study (JHS); and whether this association is modified by sex...
January 8, 2018: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/29310318/in-situ-pre-concentration-through-repeated-sampling-and-pyrolysis-for-ultrasensitive-determination-of-thallium-in-drinking-water-by-electrothermal-atomic-absorption-spectrometry
#17
Liwei Liu, Huaili Zheng, Bincheng Xu, Lang Xiao, Yong Chigan, Yilan Zhangluo
In this paper, a procedure for in-situ pre-concentration in graphite furnace by repeated sampling and pyrolysis is proposed for the determination of ultra-trace thallium in drinking water by graphite furnace atomic absorption spectrometry (GF-AAS). Without any other laborious enrichment processes that routinely result in analyte loss and contamination, thallium was directly concentrated in the graphite furnace automatically and subsequently subject to analysis. The effects of several key factors, such as the temperature for pyrolysis and atomization, the chemical modifier, and the repeated sampling times were investigated...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29310314/determination-of-silicon-in-biomass-and-products-of-pyrolysis-process-via-high-resolution-continuum-source-atomic-absorption-spectrometry
#18
Flávio V Nakadi, Caroline Prodanov, Wiliam Boschetti, Maria Goreti R Vale, Bernhard Welz, Jailson B de Andrade
Thermochemical processes can convert the biomass into fuels, such as bio-oil. The biomass submitted to pyrolysis process, such as fibers, are generally rich in silicon, an element that can lead to damages in an engine when there is high concentration in a fuel. High-resolution continuum source atomic absorption spectrometry (HR-CS AAS) is an interesting alternative for Si determination in the products and byproducts of the pyrolysis process because, besides the flame (F) and graphite furnace (GF) atomizers, it has enhanced the application of direct analysis of solid samples (SS) within GF...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29309983/interaction-between-the-contributions-of-tumor-location-tumor-grade-and-patient-age-to-the-survival-benefit-associated-with-gross-total-resection-gtr
#19
Kate T Carroll, Alex K Bryant, Brian Hirshman, Ali A Alattar, Rushikesh Joshi, Brandon Gabel, Bob S Carter, Olivier Harismendy, Florin Vaida, Clark C Chen
BACKGROUND: Gross total resection (GTR) in glioblastoma (GB) and anaplastic astrocytoma (AA) patients is associated with improved survival. Here, we examine how this benefit is affected by tumor location, tumor grade, and age. METHODS: We selected patients in SEER with lobar AA or GB from 1999 to 2010. Survival analyses were performed using Kaplan-Meier curves and Cox proportional hazards models. RESULTS: We identified and studied 1,429 AA patients and 12,537 GB patients in the SEER database with lobar tumors...
January 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29308212/-the-efficacy-of-extracorporeal-liver-support-with-molecular-adsorbent-recirculating-system-in-severe-drug-induced-liver-injury
#20
Jaishvi Eapen, Rotimi Ayoola, Ram M Subramanian
We report a case of a 26-year-old man with no significant medical history, who presented with fatigue, pruritus, jaundice, dark urine and clay colored stool for one month. He had been taking methyl-1-etiochoenolol-epietiocholanolone, an androgenic anabolic steroid (AAS). He was initially found to have a total bilirubin (Tbili) of 6 mg/dL. He discontinued the AAS but the patients' symptoms worsened and Tbili increased to 36 mg/d. This prompted inpatient management of his drug-induced liver injury (DILI). Molecular adsorbent recirculating system (MARS) is an extracorporeal liver support system that replaces the detoxification function of the liver...
January 2018: Oxford Medical Case Reports
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