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https://www.readbyqxmd.com/read/29150471/biochemical-monitoring-after-initiation-of-aldosterone-antagonist-therapy-in-users-of-renin-angiotensin-system-blockers-a-uk-primary-care-cohort-study
#1
Sarah-Jo Sinnott, Kathryn E Mansfield, Morten Schmidt, Krishnan Bhaskaran, Liam Smeeth, Dorothea Nitsch, Laurie A Tomlinson
OBJECTIVE: To determine the frequency of biochemical monitoring after initiation of aldosterone antagonists(AA) in patients also using angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEI/ARB). SETTING: UK primary care. PARTICIPANTS: ACEI/ARB users who initiated AA between 2004 and 2014. OUTCOMES: We calculated the proportions with: (1) biochemical monitoring ≤2 weeks post initiation of AA, (2) adverse biochemical values ≤2 months (potassium ≥6 mmol/L, creatinine ≥220 µmol/L and ≥30% increase in creatinine from baseline) and (3) discontinuers of AA in those with an adverse biochemical value...
November 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29145092/ionic-liquid-solvent-bar-micro-extraction-of-cdcln-n-2-species-for-ultra-trace-cd-determination-in-seawater
#2
Belén Herce-Sesa, José A López-López, Carlos Moreno
Water analysis of trace metals has been benefited by recent studies on sample preparation by liquid micro-extraction. However, there are still limitations for its application to seawater, such as the need of additives to preserve the sample or the availability of chemical extractants for the selective extraction from highly saline samples. In this work, a three phase solvent bar micro-extraction (3SBME) system containing the ionic liquid trioctylmethylammonium chloride (Aliquat(®) 336) has been used for isolation and pre-concentration of Cd from seawater samples, due to its ability for ionic exchange of CdCln((n-2)-)...
November 1, 2017: Chemosphere
https://www.readbyqxmd.com/read/29141576/analysis-of-elevated-levels-of-nandrolone-decanoate-induced-cytochrome-p450-alterations-in-mice
#3
Parmita Chowdhury, Rita Mahantab
BACKGROUND: Frequent non-medicated use of anabolic androgenic steroids (AAS) is an instance of substance abuse which mimics the status of a natural hormone and upon prolonged exposure may lead to adverse drug reactions. These adverse drug reactions proceed in a manner so as to alter the normal metabolism of an enzyme mediated pathway such as the cytochrome P450 (CYP) family of enzymes. OBJECTIVE: The present study was conducted to investigate the impact of overuse of Nandrolone Decanoate (ND), an AAS, upon CYP enzyme activity and a CYP gene, belonging to CYP1 family...
November 14, 2017: Drug Metabolism Letters
https://www.readbyqxmd.com/read/29140312/plasma-amino-acid-abnormalities-in-chronic-heart-failure-mechanisms-potential-risks-and-targets-in-human-myocardium-metabolism
#4
Roberto Aquilani, Maria Teresa La Rovere, Daniela Corbellini, Evasio Pasini, Manuela Verri, Annalisa Barbieri, Anna Maria Condino, Federica Boschi
The goal of this study was to measure arterial amino acid levels in patients with chronic heart failure (CHF), and relate them to left ventricular function and disease severity. Amino acids (AAs) play a crucial role for heart protein-energy metabolism. In heart failure, arterial AAs, which are the major determinant of AA uptake by the myocardium, are rarely measured. Forty-one subjects with clinically stable CHF (New York Heart Association (NYHA) class II to IV) were analyzed. After overnight fasting, blood samples from the radial artery were taken to measure AA concentrations...
November 15, 2017: Nutrients
https://www.readbyqxmd.com/read/29138359/comparative-effects-of-intraduodenal-amino-acid-infusions-on-food-intake-and-gut-hormone-release-in-healthy-males
#5
Robert E Steinert, Sina S Ullrich, Nori Geary, Lori Asarian, Marco Bueter, Michael Horowitz, Christine Feinle-Bisset
In contrast to the many studies of the effects of individual amino acids (AAs) on eating, no studies have compared the effects of different AAs on eating and underlying preabsorptive gastrointestinal mechanisms. To compare the effects of intraduodenal infusions of l-tryptophan (TRP), l-leucine (LEU), l-phenylalanine (PHE) and l-glutamine (GLN) on appetite, gastrointestinal hormone responses (including ghrelin, cholecystokinin (CCK), peptide YY (PYY) and glucagon-like peptide-1 [GLP-1]), glycemia (glucagon, insulin and glucose) and test meal size in healthy males, we retrospectively analyzed data from four published independent, randomized, double-blind, placebo-controlled studies of 90-min intraduodenal infusions of the individual AAs...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29137191/maternal-iodine-intake-and-offspring-attention-deficit-hyperactivity-disorder-results-from-a-large-prospective-cohort-study
#6
Marianne Hope Abel, Eivind Ystrom, Ida Henriette Caspersen, Helle Margrete Meltzer, Heidi Aase, Liv Elin Torheim, Ragna Bugge Askeland, Ted Reichborn-Kjennerud, Anne Lise Brantsæter
Current knowledge about the relationship between mild to moderately inadequate maternal iodine intake and/or supplemental iodine on child neurodevelopment is sparse. Using information from 77,164 mother-child pairs in the Norwegian Mother and Child Cohort Study, this study explored associations between maternal iodine intake and child attention-deficit/hyperactivity disorder (ADHD) diagnosis, registered in the Norwegian Patient Registry and maternally-reported child ADHD symptoms at eight years of age. Pregnant women reported food and supplement intakes by questionnaire in gestational week 22...
November 13, 2017: Nutrients
https://www.readbyqxmd.com/read/29131455/effects-of-supplementary-amino-acids-on-available-energy-of-soybean-meal-determined-by-difference-and-regression-methods-fed-to-growing-pigs
#7
Jinbiao Zhao, Chuanxin Shi, Zhongchao Li, Ji Wang, Ling Liu, Defa Li, Shuai Zhang
This study was conducted to evaluate effects of inclusion level and supplementary amino acids (AAs) on digestible energy (DE) and metabolizable energy (ME) values of soybean meal (SBM) fed to growing pigs, determined by difference and regression methods. Sixty pigs were fed 10 diets according to a 5 × 2 factorial arrangement. Two control diets contained 97.34% corn without supplementary AAs or 95.61% corn with supplementary AAs. Eight diets were formulated by replacing corn and AAs in control diets with 8%, 15%, 25% and 31% SBM...
November 12, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/29130776/new-insights-into-effects-of-aromatic-amino-acids-on-hydroxyapatite
#8
Y R Guo, X Yang, X W Feng, Y Sa, M Wang, P Li, T Jiang
Biomimetics inspired by superstructures and extraordinary properties of teeth have resulted in tooth repair and the generation of novel materials. However, little attention has been paid to tooth color, whose origin remains unknown. Based on recent studies, fluorophores-mainly aromatic amino acids (AAAs) in proteins-might be responsible for tooth color. We synthesized carbonated hydroxyapatite (HA; the mineral phase of teeth) in the presence of different amino acids (AAs; the basic units of protein matrix of teeth) as a simplified model of teeth to explore the color source at the AA level...
November 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29128501/the-strategic-imperative-for-the-use-of-social-media-in-health-care
#9
Amy L Kotsenas, Makala Arce, Lee Aase, Farris K Timimi, Colleen Young, John T Wald
Although health care lags behind many other industries in adopting social media as part of a business strategy, the Mayo Clinic recognized the importance of these applications more than a decade ago. In addition to typical media relations and marketing tactics, the Mayo Clinic has successfully used social media as part of an overall program to support the strategic imperatives of the institution.
November 9, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29128500/the-social-media-dna-of-mayo-clinic-and-health-care
#10
Amy L Kotsenas, Lee Aase, Makala Arce, Farris K Timimi, Matthew Dacy, Colleen Young, John T Wald
Hippocrates' admonition and the medical community's aversion to risk have caused many physicians and institutions to resist participation in modern social media sites such as Facebook (Facebook, Inc, Menlo Park, California, USA), Twitter (Twitter Inc, San Francisco, California, USA), and YouTube (San Mateo, California, USA). However, because Mayo Clinic's founders were champions of analog social networking, it was among the earliest hospitals worldwide to create official accounts on these digital platforms...
November 8, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29127884/regional-dysregulation-of-taurine-and-related-amino-acids-in-the-fetal-rat-brain-following-gestational-alcohol-exposure
#11
Raine Lunde-Young, Katie Davis-Anderson, Vishal Naik, Matthew Nemec, Guoyao Wu, Jayanth Ramadoss
The fetal brain exhibits exquisite alcohol-induced regional neuronal vulnerability. A candidate mechanism for alcohol-mediated brain deficits is disruption of amino acid (AA) bioavailability. AAs are vitally important for proper neurodevelopment, as they comprise the most abundant neurotransmitters in the brain and act as neurotransmitter precursors, nitric oxide donors, antioxidants, and neurotrophic factors, which induce synaptogenesis, neuronal proliferation, and migration. We hypothesized that gestational alcohol alters brain AA concentrations, disrupts AAs associated with neuropathogenesis, and that alterations are region-specific...
September 30, 2017: Alcohol
https://www.readbyqxmd.com/read/29126872/phylogenetic-analyses-of-denv-3-isolated-from-field-caught-mosquitoes-in-thailand
#12
Thikhumporn Sittivicharpinyo, Passorn Wonnapinij, Wunrada Surat
Dengue virus serotype 3 (DENV-3) can cause all forms of dengue diseases and is a predominant serotype in many countries. This serotype is classified into five genotypes: I-V. Genotypes I-III have widely spread throughout the world, whereas genotypes IV and V are rare. Despite the impact on the spread of dengue diseases, only a few studies have reported the characteristics of DENV present in mosquito vectors. Hence, this study aimed to identify DENV-3 genotypes and reveal genetic variation of this virus presented in field-caught mosquitoes collected from endemic areas in Thailand during 2011-2015...
November 8, 2017: Virus Research
https://www.readbyqxmd.com/read/29124547/online-reduction-of-artifacts-in-eeg-of-simultaneous-eeg-fmri-using-reference-layer-adaptive-filtering-rlaf
#13
David Steyrl, Gunther Krausz, Karl Koschutnig, Günter Edlinger, Gernot R Müller-Putz
Simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) allow us to study the active human brain from two perspectives concurrently. Signal processing based artifact reduction techniques are mandatory for this, however, to obtain reasonable EEG quality in simultaneous EEG-fMRI. Current artifact reduction techniques like average artifact subtraction (AAS), typically become less effective when artifact reduction has to be performed on-the-fly. We thus present and evaluate a new technique to improve EEG quality online...
November 9, 2017: Brain Topography
https://www.readbyqxmd.com/read/29122638/neural-indices-of-emotional-reactivity-and-regulation-predict-course-of-ptsd-symptoms-in-combat-exposed-veterans
#14
Jacklynn M Fitzgerald, Stephanie M Gorka, Autumn Kujawa, Julia A DiGangi, Eric Proescher, Justin E Greenstein, Darrin M Aase, Christopher Schroth, Kaveh Afshar, Amy E Kennedy, Greg Hajcak, K Luan Phan
After diagnosis, veterans with posttraumatic stress disorder (PTSD) display significant variability in the natural course of illness (Bonanno et al., 2012)). Cross-sectional work reveals that abnormal neural response during emotion reactivity-measured using the late positive potential (LPP)-correlates with PTSD symptom severity; however, whether the LPP during emotional reactivity and regulation predicts symptoms over time is unknown. The current study examined the LPP during emotion reactivity and regulation as predictors of PTSD symptoms over one year in OEF/OIF/OND combat-exposed veterans...
November 6, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29120131/in-vitro-effects-of-selenium-on-human-glioblastoma-multiforme-cell-lines-a-preliminary-study
#15
(no author information available yet)
Glioblastoma multiforme (GBM) is caused by the central nervous system-derived glial cells, and represents the most common (50%-60%) form of primary brain tumors. The aim of this study was to investigate the in vitro effects of selenium on human GBM cells. In the present study, GMS-10 and DBTRG-05MG human GBM cell lines were used as a model to examine selenium entering the cell, cell proliferation, cytotoxicity, DNA fragmentation and Ki-67 protein expression in selenomethionine treated and non-treated groups...
March 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29119793/a-comprehensive-approach-to-assess-feathermeal-as-an-alternative-protein-source-in-aquafeed
#16
Mohammad Sedigh Jasour, Liane Wagner, Ulrik Kræmer Sundekilde, Bodil K Larsen, Ines Greco, Vibeke Orlien, Karsten Olsen, Hanne T Rasmussen, Niels H Hjermitslev, Marianne Hammershøj, Anne J T Dalsgaard, Trine Kastrup Dalsgaard
The effect of partially replacing fishmeal in aquafeed with feathermeal (FTH) at three levels (0%: FTH0, 8%: FTH8, 24%: FTH24) and two extrusion temperatures (100 and 130 °C) were evaluated in rainbow trout (Oncorhynchus mykiss) with respect to growth performance, metabolism response, and oxidative status of the feed proteins. Multivariate data analyses revealed that FTH24 correlated positively with high levels of: oxidation products, amino acids (AA) racemization, glucogenic AAs level in liver, feed intake (FI), specific growth rate (SGR), and feed conversion ratio (FCR); and low AAs digestibility...
November 9, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29110076/testing-hypoxia-physiological-effects-of-long-term-exposure-in-two-freshwater-fishes
#17
Kayla L Gilmore, Zoe A Doubleday, Bronwyn M Gillanders
Hypoxic or oxygen-free zones are linked to large-scale mortalities of fauna in aquatic environments. Studies investigating the hypoxia tolerance of fish are limited and focused on marine species and short-term exposure. However, there has been minimal effort to understand the implications of long-term exposure on fish and their ability to acclimate. To test the effects of long-term exposure (months) of fish to hypoxia we devised a novel method to control the level of available oxygen. Juvenile golden perch (Macquaria ambigua ambigua), and silver perch (Bidyanus bidyanus), two key native species found within the Murray Darling Basin, Australia, were exposed to different temperatures (20, 24 and 28 °C) combined with normoxic (6-8 mgO2 L(-1) or 12-14 kPa) and hypoxic (3-4 mgO2 L(-1) or 7-9 kPa) conditions...
November 6, 2017: Oecologia
https://www.readbyqxmd.com/read/29107730/determination-of-the-authenticity-of-plastron-derived-functional-foods-based-on-amino-acid-profiles-analysed-by-mekc
#18
Lin-Qiu Li, Joewel T Baibado, Qing Shen, Hon-Yeung Cheung
Plastron is a nutritive and superior functional food. Due to its limited supply yet enormous demands, some functional foods supposed to contain plastron may be forged with other substitutes. This paper reports a novel and simple method for determination of the authenticity of plastron-derived functional foods based on comparison of the amino acid (AA) profiles of plastron and its possible substitutes. By applying micellar electrokinetic chromatography (MEKC), 18 common AAs along with another 2 special AAs - hydroxyproline (Hyp) and hydroxylysine (Hyl) were detected in all plastron samples...
October 16, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29106452/acute-aortic-syndromes-diagnosis-and-management-an-update
#19
Eduardo Bossone, Troy M LaBounty, Kim A Eagle
Acute aortic syndromes (AAS) encompass a constellation of life-threatening medical conditions including classic acute aortic dissection (AAD), intramural haematoma, and penetrating atherosclerotic aortic ulcer. Given the non-specific symptoms and physical signs, a high clinical index of suspicion is necessary to detect the disease before irreversible lethal complications occur. In order to reduce the diagnostic time delay, a comprehensive flowchart for decision-making based on pre-test sensitivity of AAS has been designed by the European Society of Cardiology guidelines on aortic diseases and should be thus applied in the emergency scenario...
June 30, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29105125/prevalence-and-correlates-of-tattooing-in-norway-a-large-scale-cross-sectional-study
#20
Dominic Sagoe, Ståle Pallesen, Cecilie Schou Andreassen
To our knowledge, no previous large-scale study has examined the prevalences and correlates of having only easily concealed tattoos, or readily visible tattoos. We conducted an exploratory online survey in Norway asking 15,654 (6,151 females) persons aged 16-91 (m = 33.65 ± 12.27) about various demographic, sports, substance use, mental health, personality, and tattooing questions. The estimated prevalence of tattooing was 20.8% (females: 23.8%, males: 17.9%), of which 13.3% had readily visible tattoos. Results of multivariate logistic regression analysis indicated that females, being older than 19 years, higher body mass index, lifetime anabolic-androgenic steroid use (AAS), and higher scores on extraversion were associated with higher odds of having a tattoo...
December 2017: Scandinavian Journal of Psychology
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