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https://www.readbyqxmd.com/read/27924264/specificity-of-broad-protein-interaction-surfaces-for-proteins-with-multiple-binding-partners
#1
Nobuyuki Uchikoga, Yuri Matsuzaki, Masahito Ohue, Yutaka Akiyama
Analysis of protein-protein interaction networks has revealed the presence of proteins with multiple interaction ligand proteins, such as hub proteins. For such proteins, multiple ligands would be predicted as interacting partners when predicting all-to-all protein-protein interactions (PPIs). In this work, to obtain a better understanding of PPI mechanisms, we focused on protein interaction surfaces, which differ between protein pairs. We then performed rigid-body docking to obtain information of interfaces of a set of decoy structures, which include many possible interaction surfaces between a certain protein pair...
2016: Biophysics and Physicobiology
https://www.readbyqxmd.com/read/27922057/antiproliferative-activities-of-amaryllidaceae-alkaloids-from-lycoris-radiata-targeting-dna-topoisomerase-i
#2
Gui-Lin Chen, Yong-Qiang Tian, Jian-Lin Wu, Na Li, Ming-Quan Guo
Crude Amaryllidaceae alkaloids (AAs) extracted from Lycoris radiata are reported to exhibit significant anti-cancer activity. However, the specific alkaloids responsible for the pharmacodynamic activity and their targets still remain elusive. In this context, we strived to combine affinity ultrafiltration with topoisomerase I (Top I) as a target enzyme aiming to fish out specific bioactive AAs from Lycoris radiata. 11 AAs from Lycoris radiata were thus screened out, among which hippeastrine (peak 5) with the highest Enrichment factor (EF) against Top I exhibited good dose-dependent inhibition with IC50 at 7...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27918943/expression-of-metallothionein-in-the-liver-and-kidneys-of-the-red-deer-cervus-elaphus-l-from-an-industrial-metal-smelting-area-of-poland
#3
Maciej Durkalec, Rafał Kolenda, Tomasz Owczarek, Józef Szkoda, Agnieszka Nawrocka, Jędrzej Grzegrzółka, Piotr Dzięgiel, Piotr Socha, Roman Kołacz, Peter Schierack, Jan Żmudzki, Andrzej Posyniak
The metallothionein 1 (MT1) coding sequence of red deer was identified and compared to orthologous sequences from other mammals. Over 90% identity was observed between red deer MT1 amino acid sequence and MT1 sequences of other ruminants. Liver and kidney samples of red deer were collected from the industrial zinc smelting site of Miasteczko Slaskie and from the Masuria Lake District serving as a pollution-free control site. The concentrations of cadmium (Cd), lead (Pb), copper (Cu) and zinc (Zn) were analyzed by the atomic absorption spectrometry technique (AAS)...
December 2, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27917742/amino-acid-utilization-and-body-composition-of-growing-pigs-fed-processed-soybean-meal-or-rapeseed-meal-with-or-without-amino-acid-supplementation
#4
T G Hulshof, A F B van der Poel, W H Hendriks, P Bikker
Feed ingredients used in swine diets are often processed to improve nutritional value. However, (over-)processing may result in chemical reactions with amino acids (AAs) that decrease their ileal digestibility. This study aimed to determine effects of (over-)processing of soybean meal (SBM) and rapeseed meal (RSM) on post-absorptive utilization of ileal digestible AAs for retention and on body AA composition of growing pigs. Soybean meal and RSM were processed by secondary toasting in the presence of lignosulfonate to obtain processed soybean meal (pSBM) and processed rapeseed meal (pRSM)...
December 5, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27912183/relationships-between-sulfachloropyridazine-sodium-zinc-and-sulfonamide-resistance-genes-during-the-anaerobic-digestion-of-swine-manure
#5
Ranran Zhang, Jie Gu, Xiaojuan Wang, Xun Qian, Manli Duan, Wei Sun, Yajun Zhang, Haichao Li, Yang Li
In this study, swine manure containing sulfachloropyridazine sodium (SCPS) and zinc was subjected to mesophilic (37°C) anaerobic digestion (AD). The absolute abundances (AAs) of antibiotic resistance genes (ARGs) were evaluated, as well as intI1 and intI2, and the degradation of SCPS according to variation in the amount of bio-available zinc (bio-Zn). In digester that only contained SCPS, the concentrations of SCPS were lower than that digesters both contain SCPS and Zn. Compared with the control digester, the addition of SCPS increased the AAs of sul1, sul3, drfA1, and drfA7 by 1...
October 21, 2016: Bioresource Technology
https://www.readbyqxmd.com/read/27910792/optimization-of-liquid-fermentation-conditions-and-protein-nutrition-evaluation-of-mycelium-from-the-caterpillar-medicinal-mushroom-cordyceps-militaris-ascomycetes
#6
Jie Gang, Han Liu, Yanhong Liu
Cordyceps militaris is a well-known traditional Chinese medicinal mushroom. In this study, the mycelium of C. militaris was cultured using liquid fermentation technology and the culture medium components were optimized by the orthogonal test method. Our results showed that the optimal medium combination for the mycelium growth is 3% glucose, 3% peptone, 0.1% MgSO4, and 0.2% KH2PO4 The international general nutritional assessment method was applied to the overall evaluation of the protein nutrition value of submerged cultivated mycelium and fruit body of C...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27910283/feeding-behaviors-during-home-based-treatment-of-moderate-acute-malnutrition-using-corn-soy-blends-or-lipid-based-nutrient-supplements
#7
Ann-Sophie Iuel-Brockdorf, Albertine Ouedraogo, Christian Ritz, Tania Aase Draebel, Per Ashorn, Suzanne Filteau, Kim F Michaelsen
Feeding behaviors have an important impact on children's nutritional status and are essential to consider when implementing nutrition programs. The objective of this study was to explore and compare feeding behaviors related to supplementary feeding with corn-soy blends (CSB) and lipid-based nutrient supplements (LNS) based on best practice feeding behaviors. The study was conducted as part of a randomized controlled trial assessing the effectiveness of new formulations of CSB and LNS and comprised 1,546 children from 6 to 23 months...
December 2, 2016: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/27908410/elevated-serum-mda-and-depleted-non-enzymatic-antioxidants-macro-minerals-and-trace-elements-are-associated-with-bipolar-disorder
#8
Manjurul Islam Chowdhury, Maimuna Hasan, Mohammad Safiqul Islam, Md Shahid Sarwar, Mohammad Nurul Amin, S M Naim Uddin, Md Zahedur Rahaman, Sujan Banik, Md Saddam Hussain, Kazushige Yokota, Abul Hasnat
Genetic and neurobiological factors are considered to be the major causes of mood and mental disorders. However, over the past few years, increased levels of serum malondialdehyde and altered levels of various non-enzymatic antioxidants and essential minerals involved in abnormal functional activity have been identified as major contributing factors to the pathogenesis of several neurological disorders. The aim of this study was to determine the levels of the serum lipid peroxidation product malondialdehyde (MDA), antioxidants (vitamin A, E and C), macro-minerals (calcium, potassium and sodium) and trace elements (zinc, iron and selenium) in patients with bipolar disorder and to explore their role in disease progression...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27904986/a-qualitative-study-of-clinicians-experience-with-rating-of-the-global-assessment-of-functioning-gaf-scale
#9
I H Monrad Aas, Ove Sonesson, Steffen Torp
The severity of illness in psychiatry is rated using the Global Assessment of Functioning (GAF) scale. The GAF scale is often used in both research settings and in the clinic. The scale ranges from 1 to 100 and is subdivided into ten 10-point intervals, each with verbal rating instructions called anchor points and examples. GAF is an instrument that needs improvement. Studying clinicians' experiences with this rating system may be important for developing improvements. The aim of this study was to collect information from clinicians about their experiences with the GAF instrument, and to collect their ideas on how the GAF scale can be improved, particularly in the area of verbal instructions (i...
November 30, 2016: Community Mental Health Journal
https://www.readbyqxmd.com/read/27903785/microstructure-and-mechanics-of-healthy-and-aneurysmatic-abdominal-aortas-experimental-analysis-and-modelling
#10
Justyna A Niestrawska, Christian Viertler, Peter Regitnig, Tina U Cohnert, Gerhard Sommer, Gerhard A Holzapfel
Soft biological tissues such as aortic walls can be viewed as fibrous composites assembled by a ground matrix and embedded families of collagen fibres. Changes in the structural components of aortic walls such as the ground matrix and the embedded families of collagen fibres have been shown to play a significant role in the pathogenesis of aortic degeneration. Hence, there is a need to develop a deeper understanding of the microstructure and the related mechanics of aortic walls. In this study, tissue samples from 17 human abdominal aortas (AA) and from 11 abdominal aortic aneurysms (AAA) are systematically analysed and compared with respect to their structural and mechanical differences...
November 2016: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/27897327/high-performance-liquid-chromatography-evaluation-of-the-enantiomeric-purity-of-amino-acids-by-means-of-automated-precolumn-derivatization-with-ortho-phthalaldehyde-and-chiral-thiols
#11
Raphael Kühnreich, Ulrike Holzgrabe
The use of ortho-phthalaldehyde (OPA) for the derivatization of amino acids (AA) is well known. It enables the separation of the derivatives on common reversed phase columns and improves the sensitivity with fluorescence detection. With the use of a chiral thiol an indirect enantioseparation of chiral amines and AAs is feasible. The major drawback of the OPA-derivatization is the poor stability of the products. Here, a method with an in-needle derivatization procedure is optimized to facilitate a quantitative conversion of the AA with OPA and the chiral thiols N-acetyl-L-cysteine or N-isobutyryl-L-cysteine, followed by a subsequent analysis, eluding the stability issue...
December 2016: Chirality
https://www.readbyqxmd.com/read/27894372/affective-lability-mediates-the-association-between-childhood-trauma-and-suicide-attempts-mixed-episodes-and-co-morbid-anxiety-disorders-in-bipolar-disorders
#12
M Aas, C Henry, F Bellivier, M Lajnef, S Gard, J-P Kahn, T V Lagerberg, S R Aminoff, T Bjella, M Leboyer, O A Andreassen, I Melle, B Etain
BACKGROUND: Many studies have shown associations between a history of childhood trauma and more severe or complex clinical features of bipolar disorders (BD), including suicide attempts and earlier illness onset. However, the psychopathological mechanisms underlying these associations are still unknown. Here, we investigated whether affective lability mediates the relationship between childhood trauma and the severe clinical features of BD. METHOD: A total of 342 participants with BD were recruited from France and Norway...
November 29, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27892830/risk-assessment-of-plant-food-supplements-and-other-herbal-products-containing-aristolochic-acids-using-the-margin-of-exposure-moe-approach
#13
Rozaini Abdullah, Leolean Nyle Diaz, Sebastiaan Wesseling, Ivonne M C M Rietjens
After the incidences of induction of Aristolochic Acid Nephropathy after consumption of herbal weight loss preparations that accidentally contained aristolochic acids (AAs), several countries defined national restrictions on the presence of AAs in food, including plant food supplements (PFS) and herbal products. The aim of the present study was to investigate whether the risks associated with exposure to AAs via PFS and herbal products are at present indeed negligible. Data reported in literature on AA levels in PFS and other herbal products and also obtained from a new series of PFS in the present study were used to calculate the estimated daily intakes (EDIs) and corresponding Margin of Exposure (MOE) values...
November 28, 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/27891233/effectiveness-and-implementation-of-a-community-based-prevention-programme-targeting-anabolic-androgenic-steroid-use-in-gyms-study-protocol-of-a-quasi-experimental-control-group-study
#14
Yasmina Molero, Johanna Gripenberg, Ann-Sofie Bakshi
BACKGROUND: During the past decades, concerns about increased anabolic androgenic steroid (AAS) use among recreational sportspeople have been raised, yet there is a paucity of AAS prevention efforts targeting this group. Accordingly, doping prevention efforts aimed at gyms have been recommended. The overall objective of the present project is to examine a prevention programme named 100% Pure Hard Training (100% PHT), which targets AAS use among recreational sportspeople training in gyms...
2016: BMC Sports Science, Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27890594/an-investigation-of-trends-in-precious-metal-and-copper-content-of-ram-modules-in-weee-implications-for-long-term-recycling-potential
#15
Rhys Gareth Charles, Peter Douglas, Ingrid Liv Hallin, Ian Matthews, Gareth Liversage
Precious metal (PM) and copper content of dynamic-RAM modules placed on the market during 1991-2008 has been analysed by AAS following comminution and acid digestion. Linear regression analysis of compositional data ordered according to sample chronology was used to identify historic temporal trends in module composition resulting from changes in manufacturing practices, and to project future trends for use in more accurate assessment of future recycling potential. DRAM was found to be 'high grade' waste with: stable levels of gold and silver over time; 80% reduction in palladium content during 1991-2008; and 0...
November 24, 2016: Waste Management
https://www.readbyqxmd.com/read/27889932/interaction-of-hepes-buffer-with-glass-ceramic-scaffold-can-hepes-replace-tris-in-sbf
#16
Dana Rohanová, Diana Horkavcová, Laine Paidere, Aldo Roberto Boccaccini, Pavlína Bozděchová, Petr Bezdička
An international standard (ISO: 23317:2014) exists for the in vitro testing of inorganic biomaterials in simulated body fluid (SBF). This standard uses TRIS buffer to maintain neutral pH in SBF, but in our previous paper, we showed that the interaction of a tested glass-ceramic material with TRIS can produce false-positive results. In this study, we evaluated whether the HEPES buffer, which also belongs to the group of Good's buffers, would be more suitable for SBF. We compared its suitability in two media: SBF with HEPES and demineralized water with HEPES...
November 27, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27889810/rhodamine-bound-maghemite-as-a-long-term-dual-imaging-nanoprobe-of-adipose-tissue-derived-mesenchymal-stromal-cells
#17
Vratislav Cmiel, Josef Skopalik, Katerina Polakova, Jan Solar, Marketa Havrdova, David Milde, Ivan Justan, Massimiliano Magro, Zenon Starcuk, Ivo Provaznik
In the last few years, magnetically labeled cells have been intensively explored, and non-invasive cell tracking and magnetic manipulation methods have been tested in preclinical studies focused on cell transplantation. For clinical applications, it is desirable to know the intracellular pathway of nanoparticles, which can predict their biocompatibility with cells and the long-term imaging properties of labeled cells. Here, we quantified labeling efficiency, localization, and fluorescence properties of Rhodamine derivatized superparamagnetic maghemite nanoparticles (SAMN-R) in mesenchymal stromal cells (MSC)...
November 26, 2016: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/27888389/analysis-of-carcinogenic-heavy-metals-in-gallstones-and-its-role-in-gallbladder-carcinogenesis
#18
Bikash Mondal, Dhrubajyoti Maulik, Mousumi Mandal, Gautam Narayan Sarkar, Sanjay Sengupta, Debidas Ghosh
PURPOSE: Gallstone is a high-risk factor for gallbladder pre-malignancy or malignancy (GB PM-M) but which substances of gallstones definitely assist to turn out in to GB PM-M, remains unclear. This study aimed to find out the presence of carcinogenic heavy metals in gallstones and to explore the aetiopathogenesis of gallbladder pre-malignancy and malignancy. METHODS: Presence of elements in gallstones was detected by energy dispersive X-ray spectroscopy (EDS) with scanning electron microscopy (SEM) and then level of carcinogenic heavy metals was estimated in gallstones using atomic absorption spectroscopy (AAS)...
November 26, 2016: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/27887677/outcome-disparities-between-african-americans-and-caucasians-in-contemporary-kidney-transplant-recipients
#19
David J Taber, Leonard E Egede, Prabhakar K Baliga
BACKGROUND: Racial disparities in African-American (AA) kidney transplant have persisted for nearly 40 years, with limited data available on the scope of this issue in the contemporary era of transplantation. METHODS: Descriptive retrospective cohort study of US registry data including adult solitary kidney transplants between Jan 1, 2005 to Dec 31, 2009. RESULTS: 60,695 recipients were included; 41,426 Caucasians (68%) and 19,269 AAs (32%)...
November 18, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27884640/biodegradation-of-the-zno-eu-nanoparticles-in-the-tissues-of-adult-mouse-after-alimentary-application
#20
Paula Kielbik, Jaroslaw Kaszewski, Julita Rosowska, Ewelina Wolska, Bartłomiej S Witkowski, Mikolaj A Gralak, Zdzisław Gajewski, Marek Godlewski, Michal M Godlewski
Biodegradable zinc oxide nanoparticles (ZnO NPs) are considered promising materials for future biomedical applications. To fulfil this potential, biodistribution and elimination patterns of ZnO NPs in the living organism need to be resolved. In order to investigate gastrointestinal absorption of ZnO NPs and their intra-organism distribution, water suspension of ZnO or fluorescent ZnO:Eu (Europium-doped zinc oxide) NPs (10mg/ml; 0.3ml/mouse) was alimentary-administered (IG: intra-gastric) to adult mice. Internal organs collected at key time-points after IG were evaluated by AAS for Zn concentration and analysed by cytometric techniques...
November 21, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
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