keyword
https://read.qxmd.com/read/37417458/intrarenal-pressures-during-flexible-ureteroscopy-an%C3%A2-insight-into-safer-endourology
#21
JOURNAL ARTICLE
Anne Hong, Cliodhna Browne, Greg Jack, Damien Bolton
OBJECTIVES: To assess intrarenal pressures (IRPs) and complication rates after flexible ureteroscopy (fURS), and to assess factors that contribute to raised IRPs and postoperative complications. PATIENTS AND METHODS: After informed consent patients underwent fURS under general anaesthesia. The transducer of a 0.3556 mm (0.014″) pressure guidewire was placed in the renal pelvis for live recording of IRPs. The fURS procedures were performed in a routine manner under antibiotic cover with the aim of dusting the calculus to completion...
July 7, 2023: BJU International
https://read.qxmd.com/read/37319299/targeting-patients-for-early-covid-19-therapy-pre-infection-metabolic-dysfunction-polycystic-ovary-syndrome-and-risk-of-severe-disease-in-patients-under-65-a-massachusetts-community-based-observational-study
#22
JOURNAL ARTICLE
Susan R Sama, Rebecca Gore, Ann Z Bauer, Lawrence Garber, Richard Rosiello, Devi Sundaresan, Anne McDonald, David Kriebel
INTRODUCTION: The demographics of those developing severe coronavirus disease (COVID-19) outcomes are shifting to younger patients. In an observational study utilizing electronic health records from a Massachusetts group medical practice, we identified 5025 patients with confirmed COVID-19 from March 1 to December 18, 2020. Of these, 3870 were under 65 years of age. We investigated the hypothesis that pre-infection metabolic or immunologic dysregulation including polycystic ovary syndrome (PCOS) increased risk of serious COVID-19 outcomes in patients under 65 years of age...
2023: PloS One
https://read.qxmd.com/read/37022685/classifying-firearm-injury-intent-in-electronic-hospital-records-using-natural-language-processing
#23
JOURNAL ARTICLE
Erin MacPhaul, Li Zhou, Stephen J Mooney, Deborah Azrael, Andrew Bowen, Ali Rowhani-Rahbar, Ravali Yenduri, Catherine Barber, Eric Goralnick, Matthew Miller
IMPORTANCE: International Classification of Diseases-coded hospital discharge data do not accurately reflect whether firearm injuries were caused by assault, unintentional injury, self-harm, legal intervention, or were of undetermined intent. Applying natural language processing (NLP) and machine learning (ML) techniques to electronic health record (EHR) narrative text could be associated with improved accuracy of firearm injury intent data. OBJECTIVE: To assess the accuracy with which an ML model identified firearm injury intent...
April 3, 2023: JAMA Network Open
https://read.qxmd.com/read/36981911/ecg-based-semi-supervised-anomaly-detection-for-early-detection-and-monitoring-of-epileptic-seizures
#24
JOURNAL ARTICLE
Apostolos Karasmanoglou, Marios Antonakakis, Michalis Zervakis
Epilepsy is one of the most common brain diseases, characterized by frequent recurrent seizures or "ictal" states. A patient experiences uncontrollable muscular contractions, inducing loss of mobility and balance, which may result in injury or even death during these ictal states. Extensive investigation is vital to establish a systematic approach for predicting and informing patients about oncoming seizures ahead of time. Most methodologies developed are focused on the detection of abnormalities using mostly electroencephalogram (EEG) recordings...
March 12, 2023: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/36935302/multi-institutional-10-year-retrospective-review-of-amoeba-diagnosed-on-cytologic-evaluation-of-anal-pap-tests-what-is-the-significance
#25
JOURNAL ARTICLE
Yaileen D Guzmán-Arocho, T Leif Helland, Paul A VanderLaan, Vanda F Torous
INTRODUCTION: Intestinal amoebae are usually transmitted via ingestion of amoebic cysts in fecally contaminated water or food. However, other modes of transmission include sexual contact through anal-oral sex. While the primary role of anal cytology is the detection of anal cancer and precursor lesions, organisms can also be identified. Despite this, assessment of the clinical significance of cytologic identification of amoebae is lacking in the literature. MATERIALS AND METHODS: A 10-year retrospective review of the pathology archives of 2 institutions in Boston, Massachusetts was conducted...
February 3, 2023: Journal of the American Society of Cytopathology
https://read.qxmd.com/read/36865341/development-and-multi-site-external-validation-of-a-generalizable-risk-prediction-model-for-bipolar-disorder
#26
Colin G Walsh, Michael A Ripperger, Yirui Hu, Yi-Han Sheu, Drew Wilimitis, Amanda B Zheutlin, Daniel Rocha, Karmel W Choi, Victor M Castro, H Lester Kirchner, Christopher F Chabris, Lea K Davis, Jordan W Smoller
Bipolar disorder is a leading contributor to disability, premature mortality, and suicide. Early identification of risk for bipolar disorder using generalizable predictive models trained on diverse cohorts around the United States could improve targeted assessment of high risk individuals, reduce misdiagnosis, and improve the allocation of limited mental health resources. This observational case-control study intended to develop and validate generalizable predictive models of bipolar disorder as part of the multisite, multinational PsycheMERGE Consortium across diverse and large biobanks with linked electronic health records (EHRs) from three academic medical centers: in the Northeast (Massachusetts General Brigham), the Mid-Atlantic (Geisinger) and the Mid-South (Vanderbilt University Medical Center)...
February 26, 2023: medRxiv
https://read.qxmd.com/read/36858148/trends-in-delayed-diagnosis-of-critical-congenital-heart-defects-in-an-era-of-enhanced-screening-2004-2018
#27
JOURNAL ARTICLE
Rebecca F Liberman, Dominique Heinke, Angela E Lin, Eirini Nestoridi, Mitcheka Jalali, Glenn R Markenson, Sepehr Sekhavat, Mahsa M Yazdy
OBJECTIVE: To describe trends in delayed diagnosis of critical congenital heart defects (CCHDs) with prenatal and postnatal screening advances. STUDY DESIGN: We evaluated a retrospective cohort of live births with CCHD delivered between 2004 and 2018 from a statewide, population-based birth defects surveillance system in Massachusetts. Demographic information were obtained from vital records. We estimated timely (prenatal or birth/transfer hospital) and delayed diagnosis (after discharge) proportions by year and time periods coinciding with the transition to mandatory pulse oximetry in 2015...
February 28, 2023: Journal of Pediatrics
https://read.qxmd.com/read/36461071/state-level-metabolic-comorbidity-prevalence-and-control-among-adults-age-50-plus-with-diabetes-estimates-from-electronic-health-records-and-survey-data-in-five-states
#28
JOURNAL ARTICLE
Russell Mardon, Joanne Campione, Jennifer Nooney, Lori Merrill, Maurice Johnson, David Marker, Frank Jenkins, Sharon Saydah, Deborah Rolka, Xuanping Zhang, Sundar Shrestha, Edward Gregg
BACKGROUND: Although treatment and control of diabetes can prevent complications and reduce morbidity, few data sources exist at the state level for surveillance of diabetes comorbidities and control. Surveys and electronic health records (EHRs) offer different strengths and weaknesses for surveillance of diabetes and major metabolic comorbidities. Data from self-report surveys suffer from cognitive and recall biases, and generally cannot be used for surveillance of undiagnosed cases...
December 2, 2022: Population Health Metrics
https://read.qxmd.com/read/36271922/uterine-rupture-and-factors-associated-with-adverse-outcomes
#29
JOURNAL ARTICLE
Stefania K Finnsdottir, Parmida Maghsoudlou, Kristen Pepin, Xiangmei Gu, Daniela A Carusi, Jon I Einarsson, Sarah L Cohen Rassier
PURPOSE: To review cases of uterine rupture and identify risk factors associated with adverse outcomes. METHODS: This study is a retrospective cohort of complete uterine ruptures diagnosed in a large hospital system in Massachusetts between 2004 and 2018. Baseline demographics, labor characteristics and outcomes of uterine rupture were collected from medical records. RESULTS: A total of 173 cases of uterine rupture were identified. There were 30 (17...
October 22, 2022: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/36199812/assessing-optometric-care-delivered-by-telehealth-during-the-covid-19-public-health-emergency
#30
JOURNAL ARTICLE
Justine H Pidgeon, Mahesh K Bhardwaj, Patrick Titterington, Karen Latulippe, Shiyoung Roh, David J Ramsey
Background: The emergence of coronavirus disease 2019 (COVID-19) forced many eye care providers to implement telehealth services while in-person visits were reserved for essential and/or emergency eye care. Objective: This study documents how an optometry group successfully implemented telehealth to care for patients during the outbreak of the COVID-19 pandemic in the United States. Design: Retrospective, comparative case series. Methods: Records were reviewed for patients seen in an academic optometry clinic from 23 March through 7 April 2020, the period of the Massachusetts stay-at-home advisory issued in response to COVID-19...
January 2022: Therapeutic Advances in Ophthalmology
https://read.qxmd.com/read/35936173/covid-19-vaccine-booster-induced-dermatographism
#31
Mohammad A Amjad, Zamara Hamid, Pius Ochieng, Si Li
The urgent requirement for a preventative vaccination became more pressing due to the severe repercussions that the SARS-CoV-2 (COVID-19) virus had on society and the economy. The deployment of the COVID-19 vaccination program had to be expedited. As with all vaccinations, adverse events have been recorded with the COVID-19 vaccine. Some patients may experience cutaneous reactions such as rashes, itching, hives, and swelling after receiving the COVID-19 vaccine, but it is unclear how common these events are or how frequently they recur...
July 2022: Curēus
https://read.qxmd.com/read/35921180/mobile-internet-based-mixed-reality-interactive-telecollaboration-system-for-neurosurgical-procedures-technical-feasibility-and-clinical-implementation
#32
JOURNAL ARTICLE
Shiyu Zhang, Fangye Li, Yining Zhao, Ruochu Xiong, Jingyue Wang, Zhichao Gan, Xinghua Xu, Qun Wang, Huaping Zhang, Jiashu Zhang, Xiaolei Chen
OBJECTIVE: To increase access to health interventions and healthcare services for patients in resource-constrained settings, strategies such as telemedicine must be implemented for the allocation of medical resources across geographic boundaries. Telecollaboration is the dominant form of surgical telemedicine. In this study, the authors report and evaluate a novel mobile internet-based mixed-reality interactive telecollaboration (MIMIT) system as a new paradigm for telemedicine and validate its clinical feasibility...
June 2022: Neurosurgical Focus
https://read.qxmd.com/read/35840767/pregnancy-outcomes-after-first-trimester-exposure-to-buspirone-prospective-longitudinal-outcomes-from-the-mgh-national-pregnancy-registry-for-psychiatric-medications
#33
JOURNAL ARTICLE
Marlene P Freeman, Mercedes J Szpunar, Lauren A Kobylski, Heather Harmon, Adele C Viguera, Lee S Cohen
Buspirone is commonly used to treat anxiety disorders among reproductive-aged women. To date, the reproductive safety of buspirone in humans has been particularly sparse. We sought to provide preliminary data from the Massachusetts General Hospital National Pregnancy Registry for Psychiatric Medications (NPRPM) on the risk of major malformations after first-trimester buspirone exposure. The NPRPM enrolls pregnant women with psychiatric disorders to prospectively assess for major congenital malformations after in utero exposure to psychotropics...
July 16, 2022: Archives of Women's Mental Health
https://read.qxmd.com/read/35705635/case-control-study-of-neuropsychiatric-symptoms-in-electronic-health-records-following-covid-19-hospitalization-in-2-academic-health-systems
#34
JOURNAL ARTICLE
Victor M Castro, Jonathan Rosand, Joseph T Giacino, Thomas H McCoy, Roy H Perlis
Neuropsychiatric symptoms may persist following acute COVID-19 illness, but the extent to which these symptoms are specific to COVID-19 has not been established. We utilized electronic health records across 6 hospitals in Massachusetts to characterize cohorts of individuals discharged following admission for COVID-19 between March 2020 and May 2021, and compared them to individuals hospitalized for other indications during this period. Natural language processing was applied to narrative clinical notes to identify neuropsychiatric symptom domains up to 150 days following hospitalization, in addition to those reflected in diagnostic codes as measured in prior studies...
June 15, 2022: Molecular Psychiatry
https://read.qxmd.com/read/35574646/prevalence-and-phenotypic-effects-of-copy-number-variants-in-isolated-hypogonadotropic-hypogonadism
#35
JOURNAL ARTICLE
Maria I Stamou, Harrison Brand, Mei Wang, Isaac Wong, Margaret F Lippincott, Lacey Plummer, William F Crowley, Michael Talkowski, Stephanie Seminara, Ravikumar Balasubramanian
CONTEXT: The genetic architecture of Isolated Hypogonadotropic Hypogonadism (IHH) has not been completely defined. OBJECTIVE: To determine the role of copy number variants (CNVs) in IHH pathogenicity and define their phenotypic spectrum. DESIGN: Exome sequencing (ES) data in IHH probands and family members was analyzed for CNVs and single nucleotide variants (SNVs)/indels in 62 known IHH genes. IHH subjects without SNVs/indels in known genes were considered "unsolved"...
May 16, 2022: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/35491726/evaluation-of-the-safety-of-500-mg-intravenous-push-thiamine-at-a-tertiary-academic-medical-center
#36
JOURNAL ARTICLE
Mohammed Aldhaeefi, Kevin McLaughlin, Melanie Goodberlet, Paul Szumita
Background: Thiamine, also known as vitamin B1, is an essential water-soluble micronutrient. Although thiamine has minimal safety concerns, parenteral administration has been associated with rare cases of anaphylactic shock, cardiac arrest, and injection site reaction. The objective of this analysis is to evaluate the incidence of anaphylaxis and injection site reactions associated with the administration of thiamine 500 mg as an intravenous (IV) push in adult patients. Method: This single-center, retrospective analysis was performed at Brigham and Women's Hospital in Boston, Massachusetts...
April 2022: Science Progress
https://read.qxmd.com/read/35468556/stimulant-related-incident-surveillance-using-emergency-medical-service-records-in-massachusetts-2013-2020
#37
JOURNAL ARTICLE
Amy Bettano, Brandon Del Pozo, Dana Bernson, Joshua A Barocas
BACKGROUND: As stimulant use increases across the United States, emergency medical services (EMS) are crucial touchpoints in the health care system. To better measure the prevalence of stimulant use, misuse, and EMS incidents related to stimulant intoxication, definitions for stimulant-related incidents (SRIs) are needed. METHODS: We used the Massachusetts Ambulance Trip Record Information System (MATRIS) from 2013 to 2020 to develop definitions of stimulant-related incidents...
June 1, 2022: Drug and Alcohol Dependence
https://read.qxmd.com/read/35354087/informed-consent-is-poorly-documented-when-obtaining-toxicology-testing-at-delivery-in-a-massachusetts-cohort
#38
JOURNAL ARTICLE
Kathleen J Koenigs, Joseph H Chou, Samuel Cohen, Moira Nolan, Gina Liu, Mishka Terplan, Brian M Cummings, Timothy Nielsen, Nicole A Smith, Joseph Distefano, Sarah N Bernstein, Davida M Schiff
BACKGROUND: Positive toxicology testing at delivery can have enormous consequences for birthing persons and their families, including charges of child abuse or neglect and potential loss of custody for the birthing parent. Therefore state and national guidelines stipulate that, clinicians must obtain consent before toxicology testing at delivery. OBJECTIVE: This study aimed (1) to determine clinician documentation of patient consent for peripartum toxicology testing and (2) to characterize the extent to which patient and hospital characteristics were associated with documented consent...
July 2022: American journal of obstetrics & gynecology MFM
https://read.qxmd.com/read/35135527/an-outbreak-of-hiv-infection-among-people-who-inject-drugs-in-northeastern-massachusetts-findings-and-lessons-learned-from-a-medical-record-review
#39
JOURNAL ARTICLE
Liisa M Randall, Sharoda Dasgupta, Jeanne Day, Alfred DeMaria, Joseph Musolino, Betsey John, Kevin Cranston, Kate Buchacz
BACKGROUND: We conducted a medical record review for healthcare utilization, risk factors, and clinical data among people who inject drugs (PWID) in Massachusetts to aid HIV outbreak response decision-making and strengthen public health practice. SETTING: Two large community health centers (CHCs) that provide HIV and related services in northeastern Massachusetts. METHODS: Between May and July 2018, we reviewed medical records for 88 people with HIV (PWH) connected to the outbreak...
February 8, 2022: BMC Public Health
https://read.qxmd.com/read/35036094/land-use-history-impacts-spatial-patterns-and-composition-of-woody-plant-species-across-a-35-hectare-temperate-forest-plot
#40
JOURNAL ARTICLE
David A Orwig, Jason A Aylward, Hannah L Buckley, Bradley S Case, Aaron M Ellison
Land-use history is the template upon which contemporary plant and tree populations establish and interact with one another and exerts a legacy on the structure and dynamics of species assemblages and ecosystems. We use the first census (2010-2014) of a 35-ha forest-dynamics plot at the Harvard Forest in central Massachusetts to describe the composition and structure of the woody plants in this plot, assess their spatial associations within and among the dominant species using univariate and bivariate spatial point-pattern analysis, and examine the interactions between land-use history and ecological processes...
2022: PeerJ
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