Michelle M Mendonça, Amanda N Costa, Gean C A Moraes, Gustavo M Martins, Aline F Almeida, Gabriel C N Rincon, João P R Siqueira, Daniella M Padilha, Marcela I Moya, Marcos L Ferreira-Neto, Rodrigo Mello Gomes, Gustavo Rodrigues Pedrino, Marco Antônio Peliky Fontes, Eduardo Colombari, Carlos C Crestani, James O Fajemiroye, Carlos Henrique Xavier
Clonidine (CL) and Rilmenidine (RI) are among the most frequently prescribed centrally acting antihypertensives. Here, we compared CL and RI effects on psychogenic cardiovascular reactivity to sonant, luminous, motosensory, and vibrotactile stimuli during neurogenic hypertension. The femoral artery and vein of Wistar (WT - normotensive) and spontaneously hypertensive rats (SHR) were catheterized before (24 h interval) i.p. injection of vehicle (NaCl 0.9%, control - CT group), CL (10 µg/kg), or RI (10 µg/kg) and acute exposure to luminous (5000 lm), sonant (75 dB sudden tap), motor (180° cage twist), and air-jet (10 L/min - restraint and vibrotactile)...
October 2021: Fundamental & Clinical Pharmacology