keyword
https://read.qxmd.com/read/38055406/autophagy-and-anti-inflammation-ameliorate-diabetic-neuropathy-with-rilmenidine
#1
JOURNAL ARTICLE
Mehmet Burak Yalçın, Ejder Saylav Bora, Adem Çakır, Sabiye Akbulut, Oytun Erbaş
PURPOSE: To evaluate the neuroprotective effects of Rilmenidine on diabetic peripheral neuropathy (DPN) in a rat model of diabetes induced by streptozotocin (STZ). METHODS: STZ (60 mg/kg) was administered to adult Sprague-Dawley rats to induce diabetes. On the 30th day after STZ administration, electromyography (EMG) and motor function tests confirmed the presence of DPN. Group 1: Control (n = 10), Group 2: DM + 0.1 mg/kg Rilmenidine (n = 10), and Group 3: DM + 0...
2023: Acta Cirúrgica Brasileira
https://read.qxmd.com/read/7906579/-the-effect-of-rilmenidine-on-the-sympathetic-activity-of-the-renal-nerve-in-waking-barodenervated-rats
#2
COMPARATIVE STUDY
D N Maĭorov, M A Chernobel'skiĭ, O S Medvedev
The effects of intracisternal pretreatment with alpha 2-adrenoceptor antagonists which possess imidazoline (idazoxan) or nonimidazoline (yohimbine) structures on the sympatho-inhibitory action of rilmenidine were investigated in conscious sinoaortic denervated rats. Intracisternal injection of rilmendine significantly decreased renal sympathetic nerve activity. Idazoxan pretreatment prevented the sympathoinhibitory action of rilmenidine, whereas yohimbine pretreatment failed. It is concluded that the sympathoinhibitory action of rilmenidine relates more to the interaction with imidazoline receptors than alpha 2-adrenoceptors...
November 1993: Eksperimental'naia i Klinicheskaia Farmakologiia
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