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D N Maĭorov, M A Chernobel'skiĭ, O S Medvedev
The effects of intracisternal pretreatment with alpha 2-adrenoceptor antagonists which possess imidazoline (idazoxan) or nonimidazoline (yohimbine) structures on the sympatho-inhibitory action of rilmenidine were investigated in conscious sinoaortic denervated rats. Intracisternal injection of rilmendine significantly decreased renal sympathetic nerve activity. Idazoxan pretreatment prevented the sympathoinhibitory action of rilmenidine, whereas yohimbine pretreatment failed. It is concluded that the sympathoinhibitory action of rilmenidine relates more to the interaction with imidazoline receptors than alpha 2-adrenoceptors...
November 1993: Eksperimental'naia i Klinicheskaia Farmakologiia
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