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https://www.readbyqxmd.com/read/28423466/zonulin-transgenic-mice-show-altered-gut-permeability-and-increased-morbidity-mortality-in-the-dss-colitis-model
#1
Craig Sturgeon, Jinggang Lan, Alessio Fasano
Increased small intestinal permeability (IP) has been proposed to be an integral element, along with genetic makeup and environmental triggers, in the pathogenies of chronic inflammatory diseases (CIDs). We identified zonulin as a master regular of intercellular tight junctions linked to the development of several CIDs. We aim to study the role of zonulin-mediated IP in the pathogenesis of CIDs. Zonulin transgenic Hp2 mice (Ztm) were subjected to dextran sodium sulfate (DSS) treatment for 7 days, followed by 4-7 days' recovery and compared to C57Bl/6 (wild-type (WT)) mice...
April 19, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28421309/genetic-makeup-of-shiga-toxin-producing-escherichia-coli-in-relation-to-clinical-symptoms-and-duration-of-shedding-a-microarray-analysis-of-isolates-from-swedish-children
#2
A Matussek, C Jernberg, I-M Einemo, S Monecke, R Ehricht, I Engelmann, S Löfgren, S Mernelius
Shiga toxin (Stx)-producing Escherichia coli (STECs) cause non-bloody diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome, and are the primary cause of acute renal failure in children worldwide. This study investigated the correlation of genetic makeup of STEC strains as revealed by DNA microarray to clinical symptoms and the duration of STEC shedding. All STEC isolated (n = 96) from patients <10 years of age in Jönköping County, Sweden from 2003 to 2015 were included. Isolates were characterized by DNA microarray, including almost 280 genes...
April 19, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28415986/detection-of-ctx-m-15-beta-lactamases-in-enterobacteriaceae-causing-hospital-and-community-acquired-urinary-tract-infections-as-early-as-2004-in-dar-es-salaam-tanzania
#3
Joel Manyahi, Sabrina J Moyo, Marit Gjerde Tellevik, Faustine Ndugulile, Willy Urassa, Bjørn Blomberg, Nina Langeland
BACKGROUND: The spread of Extended Spectrum β-lactamases (ESBLs) among Enterobacteriaceae and other Gram-Negative pathogens in the community and hospitals represents a major challenge to combat infections. We conducted a study to assess the prevalence and genetic makeup of ESBL-type resistance in bacterial isolates causing community- and hospital-acquired urinary tract infections. METHODS: A total of 172 isolates of Enterobacteriaceae were collected in Dar es Salaam, Tanzania, from patients who met criteria of community and hospital-acquired urinary tract infections...
April 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28410388/tiger-on-the-prowl-invasion-history-and-spatio-temporal-genetic-structure-of-the-asian-tiger-mosquito-aedes-albopictus-skuse-1894-in-the-indo-pacific
#4
Andrew J Maynard, Luke Ambrose, Robert D Cooper, Weng K Chow, Joseph B Davis, Mutizwa O Muzari, Andrew F van den Hurk, Sonja Hall-Mendelin, Jeomhee M Hasty, Thomas R Burkot, Michael J Bangs, Lisa J Reimer, Charles Butafa, Neil F Lobo, Din Syafruddin, Yan Naung Maung Maung, Rohani Ahmad, Nigel W Beebe
BACKGROUND: Within the last century, increases in human movement and globalization of trade have facilitated the establishment of several highly invasive mosquito species in new geographic locations with concurrent major environmental, economic and health consequences. The Asian tiger mosquito, Aedes albopictus, is an extremely invasive and aggressive daytime-biting mosquito that is a major public health threat throughout its expanding range. METHODOLOGY/PRINCIPAL FINDINGS: We used 13 nuclear microsatellite loci (on 911 individuals) and mitochondrial COI sequences to gain a better understanding of the historical and contemporary movements of Ae...
April 14, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28409064/value-based-health-care-delivery-preventive-medicine-and-the-medicalization-of-public-health
#5
REVIEW
Andreas Vilhelmsson
The real paradigm shift for healthcare is often stated to include a transition from accentuating health care production and instead emphasize patient value by moving to a 'value-based health care delivery'. In this transition, personalized medicine is sometimes referred to as almost a panacea in solving the current and future health challenges. In theory, the progress of precision medicine sounds uncontroversial and most welcomed with its promise of a better healthcare for all, with real benefits for the individual patient provided a tailored and optimized treatment plan suitable for his or her genetic makeup...
March 1, 2017: Curēus
https://www.readbyqxmd.com/read/28407124/structure-and-biosynthesis-of-branched-wax-compounds-on-wild-type-and-wax-biosynthesis-mutants-of-arabidopsis-thaliana
#6
Lucas Busta, Reinhard Jetter
The cuticle is a waxy composite that protects the aerial organs of land plans from non-stomatal water loss. The chemical makeup of the cuticular wax mixture plays a central role in defining the water barrier, but structure-function relationships have not been established so far, in part due to gaps in our understanding of wax structures and biosynthesis. While wax compounds with saturated, linear hydrocarbon tails have been investigated in detail, very little is known about compounds with modified aliphatic tails, which comprise substantial portions of some plant wax mixtures...
April 12, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28401840/methylation-matters-fk506-binding-protein-51-fkbp5-methylation-moderates-the-associations-of-fkbp5-genotype-and-resistant-attachment-with-stress-regulation
#7
Rosa H Mulder, Jolien Rijlaarsdam, Maartje P C M Luijk, Frank C Verhulst, Janine F Felix, Henning Tiemeier, Marian J Bakermans-Kranenburg, Marinus H Van Ijzendoorn
The parent-child attachment relationship plays an important role in the development of the infant's stress regulation system. However, genetic and epigenetic factors such as FK506 binding protein 51 (FKBP5) genotype and DNA methylation have also been associated with hypothalamus-pituitary-adrenal axis functioning. In the current study, we examined how parent-child dyadic regulation works in concert with genetic and epigenetic aspects of stress regulation. We study the associations of attachment, extreme maternal insensitivity, FKBP5 single nucleotide polymorphism 1360780, and FKBP5 methylation, with cortisol reactivity to the Strange Situation Procedure in 298 14-month-old infants...
May 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28396619/the-complete-mitogenome-of-orcula-dolium-draparnaud-1801-ultra-deep-sequencing-from-a-single-long-range-pcr-using-the-ion-torrent-pgm
#8
D S J Groenenberg, J Harl, E Duijm, E Gittenberger
BACKGROUND: With the increasing capacity of present-day next-generation sequencers the field of mitogenomics is rapidly changing. Enrichment of the mitochondrial fraction, is no longer necessary for obtaining mitogenomic data. Despite the benefits, shotgun sequencing approaches also have disadvantages. They do not guarantee obtaining the complete mitogenome, generally require larger amounts of input DNA and coverage is low compared to sequencing with enrichment strategies. If the mitogenome could be amplified in a single amplification, additional time and costs for sample preparation might outweigh these disadvantages...
2017: Hereditas
https://www.readbyqxmd.com/read/28393266/postpartum-endocrine-activities-metabolic-attributes-and-milk-yield-are-influenced-by-thermal-stress-in-crossbred-dairy-cows
#9
Ihsanullah, Muhammad Subhan Qureshi, Syed Muhammad Suhail, Sohail Akhtar, Rifat Ullah Khan
This study was conducted on 30 freshly parturated multiparous crossbred dairy cows possessing three levels of Holstein Frisian genetic makeup (62.5, 75.0, and 87.5%). Data on temperature humidity index (THI) were classified into comfortable (≤ 71), mild stress (72-79), moderate stress (80-89), and stressful (≥90) zone. Results showed that serum cortisol concentration increased significantly (P < 0.05) in cows during stressful condition irrespective of genetic makeup compared to the other zones. Daily milk yield (DMY) was significantly (P < 0...
April 10, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28392645/knowledge-and-behavior-regarding-cosmetics-in-koreans-visiting-dermatology-clinics
#10
Soyun Cho, Sohee Oh, Nack In Kim, Young Suck Ro, Joung Soo Kim, Young Min Park, Chun Wook Park, Weon Ju Lee, Dong Kun Kim, Dong Won Lee, Sang Jun Lee
BACKGROUND: Cosmetics can affect the skin condition profoundly, and yet no survey has been performed in Koreans visiting dermatology clinics. OBJECTIVE: To assess knowledge and consumer behavior regarding cosmetics in Koreans visiting dermatology clinics. METHODS: A questionnaire consisting of 43 questions concerning demographics and use/knowledge/selection/purchase of cosmetics was given to patients and accompanying persons who visited dermatologic clinics in university and private clinic settings...
April 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28390713/host-mediated-effects-of-phytonutrients-in-ruminants-a-review
#11
J Oh, E H Wall, D M Bravo, A N Hristov
Plants produce an extensive array of organic compounds derived from secondary metabolism that may be useful in animal nutrition because of their chemical makeup. These plant-derived bioactive compounds, also referred to as phytonutrients (PN) or phytobiotics, have been shown to express antimicrobial activities against a wide range of bacteria, yeast, and fungi and have been investigated as rumen modifiers in ruminant nutrition. Studies have reported that PN may inhibit deamination of AA and methanogenesis in the rumen and shift fermentation toward propionate and butyrate...
April 5, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28389617/a-dedicated-spanish-language-line-increases-enrollment-of-hispanics-into-prehospital-clinical-research
#12
Nerses Sanossian, Lauren Rosenberg, David S Liebeskind, Sidney Starkman, Marc Eckstein, Samuel Stratton, Franklin D Pratt, Scott Hamilton, May Kim-Tenser, Latisha K Sharma, Lucas Restrepo, Miguel Valdes-Suieras, Robin Conwit, Jeffrey L Saver
BACKGROUND AND PURPOSE: Novel methods are needed to reduce the disparity of Hispanic enrollment in stroke clinical trials. Prehospital enrollment using a dedicated Spanish language line may help overcome this bias. METHODS: Subjects or legally authorized representatives provided information on race and ethnicity for all cases enrolled in the FAST-MAG clinical trial (Field Administration of Stroke Therapy-Magnesium), a prehospital phase 3 randomized study of intravenous magnesium for neuroprotection...
April 7, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28388507/novel-protein-kinase-targets-in-vascular-smooth-muscle-therapeutics
#13
REVIEW
David A Tulis
Many signaling factors have been identified over the years that serve as mechanistic foundations for the pathogenesis and/or maintenance of cardiovascular disease (CVD). Of these, cyclic nucleotide-driven protein kinases in vascular smooth muscle (VSM) are of essential importance. Comprised primarily of cyclic AMP-dependent and cyclic GMP-dependent protein kinases, these ubiquitous signaling molecules have capacity to operate through numerous downstream effectors including vasodilator-stimulated phosphoprotein (VASP) to control aberrant VSM growth elemental to CVD...
April 4, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/28366820/immune-related-gene-polymorphisms-in-pulmonary-diseases
#14
REVIEW
Dhirendra P Singh, Prathyusha Bagam, Malaya K Sahoo, Sanjay Batra
Between the DNA sequences of two randomly-selected human genomes, which consist of over 3 billion base pairs and twenty five thousand genes, there exists only 0.1% variation and 99.9% sequence identity. During the last couple of decades, extensive genome-wide studies have investigated the association between single-nucleotide polymorphisms (SNPs), the most common DNA variations, and susceptibility to various diseases. Because the immune system's primary function is to defend against myriad infectious agents and diseases, the large number of people who escape serious infectious diseases underscores the tremendous success of this system at this task...
March 30, 2017: Toxicology
https://www.readbyqxmd.com/read/28363714/the-effects-of-requiring-parental-consent-for-research-on-adolescents-risk-behaviors-a-meta-analysis
#15
Chao Liu, Ronald B Cox, Isaac J Washburn, Julie M Croff, Hugh C Crethar
PURPOSE: Requiring parental consent may result in sampling biases that confound scientific conclusions and stifle the representation of children most at risk for adverse outcomes. This study aims to investigate whether active parental consent, compared with passive parental consent, creates a bias in response rate, demographic makeup, and adverse outcomes in adolescent samples. METHODS: A meta-analysis was performed on peer-reviewed articles and unpublished dissertations from 1975 to 2016 in five computerized databases ERIC, PsycINFO, MEDLINE, PubMed and ProQuest...
March 28, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28360895/genetic-diversity-of-brucella-reference-and-non-reference-phages-and-its-impact-on-brucella-typing
#16
Jens A Hammerl, Cornelia Göllner, Claudia Jäckel, Holger C Scholz, Karsten Nöckler, Jochen Reetz, Sascha Al Dahouk, Stefan Hertwig
Virulent phages have been used for many years to type Brucella isolates, but until recently knowledge about the genetic makeup of these phages remains limited. In this work the host specificity and genomic sequences of the original set (deposited in 1960) of VLA Brucella reference phages Tb, Fi, Wb, Bk2, R/C, and Iz were analyzed and compared with hitherto described brucellaphages. VLA phages turned out to be different from homonymous phages in other laboratories. The host range of the phages was defined by performing plaque assays with a wide selection of Brucella strains...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28352564/bacterial-exopolysaccharide-mediated-heavy-metal-removal-a-review-on-biosynthesis-mechanism-and-remediation-strategies
#17
REVIEW
Pratima Gupta, Batul Diwan
Heavy metal contamination has been recognized as a major public health risk, particularly in developing countries and their toxicological manifestations are well known. Conventional remediation strategies are either expensive or they generate toxic by-products, which adversely affect the environment. Therefore, necessity for an environmentally safe strategy motivates interest towards biological techniques. One of such most profoundly driven approach in recent times is biosorption through microbial biomass and their products...
March 2017: Biotechnology Reports
https://www.readbyqxmd.com/read/28347287/unraveling-the-complexity-of-transcriptomic-metabolomic-and-quality-environmental-response-of-tomato-fruit
#18
Daniela D'Esposito, Francesca Ferriello, Alessandra Dal Molin, Gianfranco Diretto, Adriana Sacco, Andrea Minio, Amalia Barone, Rossella Di Monaco, Silvana Cavella, Luca Tardella, Giovanni Giuliano, Massimo Delledonne, Luigi Frusciante, Maria Raffaella Ercolano
BACKGROUND: The environment has a profound influence on the organoleptic quality of tomato (Solanum lycopersicum) fruit, the extent of which depends on a well-regulated and dynamic interplay among genes, metabolites and sensorial attributes. We used a systems biology approach to elucidate the complex interacting mechanisms regulating the plasticity of sensorial traits. To investigate environmentally challenged transcriptomic and metabolomic remodeling and evaluate the organoleptic consequences of such variations we grown three tomato varieties, Heinz 1706, whose genome was sequenced as reference and two "local" ones, San Marzano and Vesuviano in two different locations of Campania region (Italy)...
March 28, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28343247/development-of-a-qtl-environment-based-predictive-model-for-node-addition-rate-in-common-bean
#19
Li Zhang, Salvador A Gezan, C Eduardo Vallejos, James W Jones, Kenneth J Boote, Jose A Clavijo-Michelangeli, Mehul Bhakta, Juan M Osorno, Idupulapati Rao, Stephen Beebe, Elvin Roman-Paoli, Abiezer Gonzalez, James Beaver, Jaumer Ricaurte, Raphael Colbert, Melanie J Correll
This work reports the effects of the genetic makeup, the environment and the genotype by environment interactions for node addition rate in an RIL population of common bean. This information was used to build a predictive model for node addition rate. To select a plant genotype that will thrive in targeted environments it is critical to understand the genotype by environment interaction (GEI). In this study, multi-environment QTL analysis was used to characterize node addition rate (NAR, node day(- 1)) on the main stem of the common bean (Phaseolus vulgaris L)...
March 25, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28342614/genetic-analysis-of-groups-of-mid-infrared-predicted-fatty-acids-in-milk
#20
S G Narayana, F S Schenkel, A Fleming, A Koeck, F Malchiodi, J Jamrozik, J Johnston, M Sargolzaei, F Miglior
The objective of this study was to investigate genetic variability of mid-infrared predicted fatty acid groups in Canadian Holstein cattle. Genetic parameters were estimated for 5 groups of fatty acids: short-chain (4 to 10 carbons), medium-chain (11 to 16 carbons), long-chain (17 to 22 carbons), saturated, and unsaturated fatty acids. The data set included 49,127 test-day records from 10,029 first-lactation Holstein cows in 810 herds. The random regression animal test-day model included days in milk, herd-test date, and age-season of calving (polynomial regression) as fixed effects, herd-year of calving, animal additive genetic effect, and permanent environment effects as random polynomial regressions, and random residual effect...
March 22, 2017: Journal of Dairy Science
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