keyword
MENU ▼
Read by QxMD icon Read
search

Makeup

keyword
https://www.readbyqxmd.com/read/28819848/capture-and-genetic-analysis-of-circulating-tumor-cells-using-a-magnetic-separation-device-magnetic-sifter
#1
Chin Chun Ooi, Seung-Min Park, Dawson J Wong, Sanjiv S Gambhir, Shan X Wang
Circulating tumor cells (CTCs) are currently widely studied for their potential application as part of a liquid biopsy. These cells are shed from the primary tumor into the circulation, and are postulated to provide insight into the molecular makeup of the actual tumor in a minimally invasive manner. However, they are extremely rare in blood, with typical concentrations of 1-100 in a milliliter of blood; hence, a need exists for a rapid and high-purity method for isolating CTCs from whole blood. Here, we describe the application of a microfabricated magnetic sifter toward isolation of CTCs from whole blood at volumetric flow rates of 10 mL/h, along with the use of a PDMS-based nanowell system for single-cell gene expression profiling...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28816410/new-insights-into-the-cellular-makeup-and-progenitor-potential-of-palatal-connective-tissues
#2
Emoke Pall, Mihai Cenariu, Adrian Kasaj, Adrian Florea, Andrada Soancă, Alexandra Roman, Carmen Georgiu
The present study investigated the regenerative potential of connective tissues harvested from two palatal areas widely used as donor sites for muco-gingival surgical approaches. Connective tissue grafts (CTGs) were obtained by de-epithelialisation of a free gingival graft (deCTG) and by a split flap approach from a previous donor site (reCTG). Two types of mesenchymal stem cell (MSCs) were isolated and were named de-epithelialised MSCs (deMSCs) and re-entry MSCs (reMSCs). The cells were characterised and cellular functionality was investigated...
August 17, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28813271/prenatal-parenting
#3
REVIEW
Vivette Glover, Lauren Capron
Parenting begins before birth. This includes prenatal maternal and paternal bonding with the baby, and biological effects on fetal development. Recent research has confirmed how prenatal maternal stress can alter the development of the fetus and the child, and that this can persist until early adulthood. Children are affected in different ways depending, in part, on their own genetic makeup. The fetus may also have a direct effect on prenatal maternal mood and later parenting behaviour via the placenta. The father is important prenatally too...
June 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28812304/management-of-castration-resistant-taxane-resistant-prostate-cancer
#4
Tomasz M Beer
Metastatic castration-resistant prostate cancer that is progressing despite docetaxel chemotherapy is difficult to treat and often aggressive. If not previously used, modern androgen signaling inhibitors have established clinical activity in this setting. Cabazitaxel and radium-223 have also been shown to extend survival in appropriately selected patients. Carboplatin-containing chemotherapy regimens have not been studied in randomized trials with a survival endpoint, but they have demonstrated activity in phase II trials and are occasionally considered in the post-docetaxel setting...
August 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28811702/precision-medicine-in-need-of-guidance-and-surveillance
#5
EDITORIAL
Jian-Zhen Lin, Jun-Yu Long, An-Qiang Wang, Ying Zheng, Hai-Tao Zhao
Precision medicine, currently a hotspot in mainstream medicine, has been strongly promoted in recent years. With rapid technological development, such as next-generation sequencing, and fierce competition in molecular targeted drug exploitation, precision medicine represents an advance in science and technology; it also fulfills needs in public health care. The clinical translation and application of precision medicine - especially in the prevention and treatment of tumors - is far from satisfactory; however, the aims of precision medicine deserve approval...
July 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28808546/characterization-of-measurement-errors-using-structure-from-motion-and-photogrammetry-to-measure-marine-habitat-structural-complexity
#6
Mitch Bryson, Renata Ferrari, Will Figueira, Oscar Pizarro, Josh Madin, Stefan Williams, Maria Byrne
Habitat structural complexity is one of the most important factors in determining the makeup of biological communities. Recent advances in structure-from-motion and photogrammetry have resulted in a proliferation of 3D digital representations of habitats from which structural complexity can be measured. Little attention has been paid to quantifying the measurement errors associated with these techniques, including the variability of results under different surveying and environmental conditions. Such errors have the potential to confound studies that compare habitat complexity over space and time...
August 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28805218/electrochemical-de-lithiation-of-silver-ferrite-and-composites-mechanistic-insights-from-ex-situ-in-situ-and-operando-x-ray-techniques
#7
Jessica L Durham, Alexander B Brady, Christina A Cama, David C Bock, Christopher J Pelliccione, Qing Zhang, Mingyuan Ge, Yue Ru Li, Yiman Zhang, Hanfei Yan, Xiaojing Huang, Yong Chu, Esther S Takeuchi, Kenneth J Takeuchi, Amy C Marschilok
The structure of pristine AgFeO2 and phase makeup of Ag0.2FeO1.6 (a one-pot composite comprised of nanocrystalline stoichiometric AgFeO2 and amorphous γ-Fe2O3 phases) was investigated using synchrotron X-ray diffraction. A new stacking-fault model was proposed for AgFeO2 powder synthesized using the co-precipitation method. The lithiation/de-lithiation mechanisms of silver ferrite, AgFeO2 and Ag0.2FeO1.6 were investigated using ex situ, in situ, and operando characterization techniques. An amorphous γ-Fe2O3 component in the Ag0...
August 14, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28797626/marine-litter-from-beach-based-sources-case-study-of-an-eastern-mediterranean-coastal-town
#8
Michelle E Portman, Ruth E Brennan
Marine litter has been a serious and growing problem for some decades now. Yet, there is still much speculation among researchers, policy makers and planners about how to tackle marine litter from land-based sources. This paper provides insights into approaches for managing marine litter by reporting and analyzing survey results of litter dispersal and makeup from three areas along an Arab-Israeli coastal town in view of other recent studies conducted around the Mediterranean Sea. Based on our results and analysis, we posit that bathing beach activities should be a high priority for waste managers as a point of intervention and beach-goers must be encouraged to take a more active role in keeping beaches clean...
August 7, 2017: Waste Management
https://www.readbyqxmd.com/read/28769759/the-insect-ortholog-of-the-human-orphan-cytokine-receptor-crlf3-is-a-neuroprotective-erythropoietin-receptor
#9
Nina Hahn, Debbra Y Knorr, Johannes Liebig, Liane Wüstefeld, Karsten Peters, Marita Büscher, Gregor Bucher, Hannelore Ehrenreich, Ralf Heinrich
The cytokine erythropoietin (Epo) mediates various cell homeostatic responses to environmental challenges and pathological insults. While stimulation of vertebrate erythrocyte production is mediated by homodimeric "classical" Epo receptors, alternative receptors are involved in neuroprotection. However, their identity remains enigmatic due to complex cytokine ligand and receptor interactions and conflicting experimental results. Besides the classical Epo receptor, the family of type I cytokine receptors also includes the poorly characterized orphan cytokine receptor-like factor 3 (CRLF3) present in vertebrates including human and various insect species...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28764955/the-2017-acr-commission-on-human-resources-workforce-survey
#10
Edward I Bluth, Swati Bansal, Claire E Bender
PURPOSE: The ACR Commission on Human Resources conducts an annual workforce survey to determine the makeup of the radiology workforce and to identify potential plans for hiring new staff in an attempt to understand our profession better. METHODS: The Practice of Radiology Environment Database group leaders were asked to complete an electronic survey regarding the makeup of their present workforce by subspecialty, as well as the numbers and types of subspecialists hired in 2016 and the numbers and types of subspecialists expected to be hired in 2017 and 2020...
July 29, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28759720/tilt-grain-boundary-topology-induced-by-substrate-topography
#11
Henry Yu, Nitant Gupta, Zhili Hu, Kai Wang, Bernadeta R Srijanto, Kai Xiao, David B Geohegan, Boris I Yakobson
Synthesis of two-dimensional (2D) crystals is a topic of great current interest, since their chemical makeup, electronic, mechanical, catalytic, and optical properties are so diverse. A universal challenge, however, is the generally random formation of defects caused by various growth factors on flat surfaces. Here we show through theoretical analysis and experimental demonstration that nonplanar, curved-topography substrates permit the intentional and controllable creation of topological defects within 2D materials...
August 7, 2017: ACS Nano
https://www.readbyqxmd.com/read/28758261/comparison-of-two-picosecond-lasers-to-a-nanosecond-laser-for-treating-tattoos-a-prospective-randomized-study-on-49-patients
#12
Aurélie Lorgeou, Yvon Perrillat, Nathalie Gral, Sylvie Lagrange, Jean-Philippe Lacour, Thierry Passeron
BACKGROUND: Q-switched nanosecond lasers demonstrated their efficacy in treating most types of tattoos but complete disappearance is not always achieved even after performing numerous laser sessions. Picosecond lasers are supposed to be more efficient in clearing tattoos than nanosecond lasers but prospective comparative data remain limited. OBJECTIVE: To compare on different types of tattoos the efficacy of a nanosecond laser with two types of picosecond lasers...
July 31, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28754655/modeling-treatment-response-for-lamin-a-c-related-dilated-cardiomyopathy-in-human-induced-pluripotent-stem-cells
#13
Yee-Ki Lee, Yee-Man Lau, Zhu-Jun Cai, Wing-Hon Lai, Lai-Yung Wong, Hung-Fat Tse, Kwong-Man Ng, Chung-Wah Siu
BACKGROUND: Precision medicine is an emerging approach to disease treatment and prevention that takes into account individual variability in the environment, lifestyle, and genetic makeup of patients. Patient-specific human induced pluripotent stem cells hold promise to transform precision medicine into real-life clinical practice. Lamin A/C (LMNA)-related cardiomyopathy is the most common inherited cardiomyopathy in which a substantial proportion of mutations in the LMNA gene are of nonsense mutation...
July 28, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28753789/integrated-phenotypic-genotypic-analysis-of-papillary-renal-cell-carcinoma-subtypes-identification-of-prognostic-markers-cancer-related-pathways-and-implications-for-therapy
#14
Rola M Saleeb, Pamela Plant, Eriny Tawedrous, Adriana Krizova, Fadi Brimo, Andrew J Evans, Samantha Jane Wala, John Bartlett, Qiang Ding, Dina Boles, Fabio Rotando, Mina Farag, George M Yousef
BACKGROUND: Two histologic subtypes are recognized for papillary renal cell carcinoma (PRCC). Studies have shown that the subtypes differ in characteristic genetic alterations and clinical behavior. Clinically, the subtypes are managed similarly. OBJECTIVES: To analyze the biological differences between the two PRCC histological subtypes, in order to further guide their clinical management. DESIGN, SETTING, AND PARTICIPANTS: PRCC cohort consisting of 317 patients from the Cancer Genome Atlas database and our institution...
September 22, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28748526/a-craniometric-analysis-of-early-modern-romania-and-hungary-the-roles-of-migration-and-conversion-in-shaping-european-ottoman-population-history
#15
Kathryn Grow Allen, Noreen von Cramon-Taubadel
OBJECTIVES: Debate persists regarding the biological makeup of European Ottoman communities settled during the expansion of the Ottoman Empire during the 16th and 17th centuries, and the roles of conversion and migration in shaping demography and population history. The aim of this study was to perform an assessment of the biological affinities of three European Ottoman series based on craniometric data. MATERIALS AND METHODS: Craniometric data collected from three Ottoman series from Hungary and Romania were compared to European and Anatolian comparative series, selected to represent biological affinity representative of historically recorded migration and conversion influences...
July 27, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28744096/subjective-evaluation-of-uncorrected-vision-in-patients-undergoing-cataract-surgery-with-diffractive-multifocal-lenses-and-monovision
#16
Ricardo Alexandre Stock, Thaís Thumé, Luan Gabriel Paese, Elcio Luiz Bonamigo
PURPOSE: To analyze patient satisfaction and difficulties with bilateral multifocal intraocular lenses (IOLs) implantation and aspheric monofocal IOLs implantation using monovision, after cataract surgery. MATERIALS AND METHODS: A total of 61 participants were included in the study, 29 with monovision and 32 with multifocal lenses. The inclusion criteria were patients undergoing phacoemulsification for bilateral visual impairment due to cataracts and presenting with postoperative visual acuity of 20/30 or better for distance and line J3 or better for near vision...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28738319/meeting-report-intercellular-interactions-in-context-towards-a-mechanistic-understanding-of-cells-in-organs
#17
David Bryant, Aaron Johnson
The Company of Biologists held the workshop 'Intercellular interactions in context: towards a mechanistic understanding of cells in organs' at historic Wiston House in West Sussex, UK, 5-8 February 2017. The meeting brought together around 30 scientists from disparate backgrounds - yet with a common interest of how tissue morphogenesis occurs and its dysregulation leads to pathologies - to intensively discuss their latest research, the current state of the field, as well as any challenges for the future. This report summarises the concepts and challenges that arose as key questions for the fields of cell, cancer and developmental biology...
July 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28735685/utilizing-circulating-tumour-dna-in-radiation-oncology
#18
REVIEW
Ariana Rostami, Scott V Bratman
Emerging technologies for detection of circulating tumour DNA (ctDNA) are expanding the possibilities for clinical impact to patients with localized, potentially curable cancer. For such patients, ctDNA analysis could aid in prognostication, prediction of treatment response, longitudinal monitoring for adaptive treatment, and evaluation of minimal residual disease. Radiation oncologists currently have few tools at their disposal for predicting or rapidly assessing treatment efficacy. By reflecting the genetic and epigenetic makeup of tumours as well as dynamic changes with treatment, ctDNA as a biomarker for radiation response could enable new personalized treatment approaches...
July 20, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28735245/association-of-16-priority-polycyclic-aromatic-hydrocarbons-with-humic-acid-and-humin-fractions-in-a-peat-soil-and-implications-for-their-long-term-retention
#19
Weixiao Chen, Hui Wang, Qian Gao, Yin Chen, Senlin Li, Yu Yang, David Werner, Shu Tao, Xilong Wang
To elucidate the environmental fate of polycyclic aromatic hydrocarbons (PAHs) once released into soil, sixteen humic acids (HAs) and one humin (HM) fractions were sequentially extracted from a peat soil, and sixteen priority PAHs in these humic substances (HSs) were analyzed. It was found that the total concentration of 16 PAHs (∑16PAHs) increased evidently from HA1 to HA16, and then dramatically reached the highest value in HM. The trend of ∑16PAHs in HAs relates to surface carbon and C-H/C-C contents, the bulk aliphatic carbon content and aliphaticity, as well as the condensation enhancement of carbon domains, which were derived from elemental composition, XPS, (13)C NMR, as well as thermal analyses...
July 20, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28729221/sensitivity-to-cocaine-in-adult-mice-is-due-to-interplay-between-genetic-makeup-early-environment-and-later-experience
#20
Matteo Di Segni, Diego Andolina, Alessandra Coassin, Alessandra Accoto, Alessandra Luchetti, Tiziana Pascucci, Carla Luzi, Anna Rita Lizzi, Francesca R D'Amato, Rossella Ventura
Although early aversive postnatal events are known to increase the risk to develop psychiatric disorders later in life, rarely they determine alone the nature and outcome of the psychopathology, indicating that interaction with genetic factors is crucial for expression of psychopathologies in adulthood. Moreover, it has been suggested that early life experiences could have negative consequences or confer adaptive value in different individuals. Here we suggest that resilience or vulnerability to adult cocaine sensitivity depends on a "triple interaction" between genetic makeup x early environment x later experience...
July 17, 2017: Neuropharmacology
keyword
keyword
89244
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"