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https://www.readbyqxmd.com/read/28737715/latency-integration-and-reactivation-of-human-herpesvirus-6
#1
REVIEW
Shara N Pantry, Peter G Medveczky
Human herpesvirus-6A (HHV-6A) and human herpesvirus-6B (HHV-6B) are two closely related viruses that infect T-cells. Both HHV-6A and HHV-6B possess telomere-like repeats at the terminal regions of their genomes that facilitate latency by integration into the host telomeres, rather than by episome formation. In about 1% of the human population, human herpes virus-6 (HHV-6) integration into germline cells allows the viral genome to be passed down from one generation to the other; this condition is called inherited chromosomally integrated HHV-6 (iciHHV-6)...
July 24, 2017: Viruses
https://www.readbyqxmd.com/read/28728872/oropharyngeal-lesions-in-pityriasis-rosea
#2
Giulia Ciccarese, Francesco Broccolo, Alfredo Rebora, Aurora Parodi, Francesco Drago
BACKGROUND: Pityriasis rosea (PR) is an exanthematous disease associated with the endogenous systemic reactivation of human herpesvirus-6 (HHV-6) and human herpesvirus-7 (HHV-7). Oropharyngeal lesions may be associated with the exanthema, but anecdotal evidence suggests that few dermatologists are aware of their occurrence. OBJECTIVE: Classifying oropharyngeal lesions in PR, establishing their prevalence, and assessing their possible association with different PR forms...
July 17, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28704770/detection-of-oncogenic-viruses-in-water-environments-by-a-luminex-based-multiplex-platform-for-high-throughput-screening-of-infectious-agents
#3
P Di Bonito, M Iaconelli, T Gheit, M Tommasino, S Della Libera, L Bonadonna, G La Rosa
Recent studies documented the detection of viruses strongly associated with human cancer in urban sewages and other water environments worldwide. The aim of this study was to estimate the occurrence of human oncogenic viruses in environmental samples (sewage, river, marine, and pool/spa water) using highly sensitive and specific multiplex bead-based assays (Luminex technology). A total of 33 samples were analysed for 140 oncogenic viral agents, including mucosal and cutaneous human papillomaviruses (HPVs), human polyomaviruses (HPyV), human herpesviruses (HHV) and mouse mammary tumour virus (MMTV)...
July 5, 2017: Water Research
https://www.readbyqxmd.com/read/28699856/analysis-of-the-origin-of-inherited-chromosomally-integrated-human-herpesvirus-6-in-the-japanese-population
#4
Yoshiki Kawamura, Tamae Ohye, Hiroki Miura, Masaru Ihira, Yuri Kato, Hiroki Kurahashi, Tetsushi Yoshikawa
Integration of the complete human herpesvirus 6 (HHV-6) genome into the telomere of a chromosome has been reported in some individuals (inherited chromosomally integrated HHV-6; iciHHV-6). Since the proportion of iciHHV-6-positive individuals with integration in chromosome 22 is high in Japan, we hypothesized a founder effect. In this study, we sought to elucidate the reason for the high proportion of viral integrations into chromosome 22. We analyzed six cases of iciHHV-6A and two cases of iciHHV-6B, including one iciHHV-6A case with a matched sample from a father and one iciHHV-6B case with a matched sample from a mother...
July 12, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28650593/hhv-6-in-liver-transplantation-a-literature-review
#5
REVIEW
Tuan L Phan, Irmeli Lautenschlager, Raymund R Razonable, Flor M Munoz
Human herpesvirus 6 (HHV-6A and HHV-6B) can cause primary infection or reactivate from latency in liver transplant recipients, which can result in a variety of clinical syndromes, including fever, hepatitis, encephalitis, and higher rates of graft dysfunction as well as indirect effects including increased risks of mortality, CMV disease, hepatitis C progression and greater fibrosis scores. Although HHV-6 infection is currently diagnosed by quantifying viral DNA in plasma or blood, biopsy to demonstrate histopathologic effects of HHV-6 remains the gold standard for diagnosis of end-organ disease...
June 26, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28601677/impact-of-stem-cell-graft-on-early-viral-infections-and-immune-reconstitution-after-allogeneic-transplantation-in-adults
#6
Marina Illiaquer, Berthe-Marie Imbert-Marcille, Thierry Guillaume, Lucie Planche, Marie Rimbert, Céline Bressollette-Bodin, Amandine Le Bourgeois, Pierre Peterlin, Alice Garnier, Claire Le Houerou, Philippe Moreau, Mohamad Mohty, Patrice Chevallier
BACKGROUND: Viral infections are well-known complications after allogeneic stem cell transplant (allo-SCT). OBJECTIVES: We compared prospectively incidences of DNAemia and active infections (AI) for five opportunistic viruses (Human Herpesvirus 6 (HHV-6), Epstein-Barr virus (EBV), BK polyomavirus (BKPyV), Cytomegalovirus (CMV) and Adenovirus (ADV)) and kinetics of immune reconstitution (IR) in adults receiving either double umbilical cord blood (dUCB group) or unrelated peripheral blood stem cell (uPBSC group) allo-SCT after a reduced-intensity conditioning (RIC) regimen...
May 31, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28598363/drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-an-interplay-among-drugs-viruses-and-immune-system
#7
REVIEW
Yung-Tsu Cho, Che-Wen Yang, Chia-Yu Chu
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe multiorgan hypersensitivity reaction mostly caused by a limited number of eliciting drugs in patients with a genetic predisposition. Patients with DRESS syndrome present with characteristic but variable clinical and pathological features. Reactivation of human herpesviruses (HHV), especially HHV-6, is the hallmark of the disease. Anti-viral immune responses intertwined with drug hypersensitivity make the disease more complicated and protracted...
June 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28596425/outcomes-of-hematopoietic-cell-transplantation-using-donors-or-recipients-with-inherited-chromosomally-integrated-hhv-6
#8
Joshua A Hill, Amalia S Magaret, Ruth Hall-Sedlak, Anna Mikhaylova, Meei-Li Huang, Brenda M Sandmaier, John A Hansen, Keith R Jerome, Danielle M Zerr, Michael Boeckh
Human herpesvirus 6 (HHV-6) species have a unique ability to integrate into chromosomal telomeres. Mendelian inheritance via gametocyte integration results in HHV-6 in every nucleated cell. The epidemiology and clinical impact of inherited chromosomally integrated (iciHHV-6) in hematopoietic cell transplant (HCT) recipients is unclear. We identified 4,319 HCT donor-recipient pairs (8,638 subjects) who received an allogeneic HCT and had archived pre-HCT peripheral blood mononuclear cell samples. We screened these samples for iciHHV-6 and compared characteristics of HCT recipients and donors with iciHHV-6 to recipients and donors without iciHHV-6, respectively...
June 8, 2017: Blood
https://www.readbyqxmd.com/read/28570620/viral-etiologies-in-adult-patients-with-encephalitis-in-poland-a-prospective-single-center-study
#9
Marta Popiel, Karol Perlejewski, Agnieszka Bednarska, Tomasz Dzieciątkowski, Marcin Paciorek, Dariusz Lipowski, Monika Jabłonowska, Hanna Czeszko-Paprocka, Iwona Bukowska-Ośko, Kamila Caraballo Cortes, Agnieszka Pawełczyk, Maria Fic, Andrzej Horban, Marek Radkowski, Tomasz Laskus
Encephalitis is a severe neurological syndrome associated with high morbidity and mortality as well as long-term neurological sequelae. Despite being an important public health problem, very few extensive population-based studies were conducted so far in the world and none in Central Europe. Altogether 114 consecutive patients meeting the initial criteria for encephalitis were enrolled at the Warsaw Hospital for Infectious Diseases between June 2012 and July 2015. Eighteen patients were secondarily excluded from the analysis due to incomplete data or noinfectious cause...
2017: PloS One
https://www.readbyqxmd.com/read/28551368/hhv-6-reactivation-as-a-cause-of-fever-in%C3%A2-autologous-hematopoietic-stem-cell-transplant-recipients
#10
M A Colombier, S Amorim, M Salmona, C Thieblemont, J Legoff, M Lafaurie
OBJECTIVES: We report the biological and clinical impacts possibly associated with HHV-6 reactivation in autologous hematopoietic stem cell transplant (AHSCT) recipients after intensive chemotherapy regimen for lymphoma. METHODS: We retrospectively reviewed clinical, biological, radiological, treatment and outcomes of patients with positive HHV-6 DNA in whole blood following autologous hematopoietic stem cell transplantation. RESULTS: Blood HHV-6 reactivation was reported in 27 (8...
August 2017: Journal of Infection
https://www.readbyqxmd.com/read/28543733/development-of-real-time-rt-pcr-assays-for-detection-of-three-classes-of-hhv-6a-gene-transcripts
#11
Masaru Ihira, Akiko Urashima, Hiroki Miura, Fumihiko Hattori, Yoshiki Kawamura, Ken Sugata, Tetsushi Yoshikawa
Human herpesvirus 6 (HHV-6), a member of the betaherpesvirus family, has two distinct species: HHV-6A and HHV-6B. HHV-6B real-time reverse transcription polymerase chain reaction (RT-PCR) has been used to distinguish between active and latent viral infection. In this study, we developed a real-time RT-PCR assay to detect HHV-6A-specific transcripts and evaluated its reliability for analysis of clinical samples. To develop HHV-6A-specific real-time RT-PCR assays, three different classes of gene transcripts (immediate early: U90; early: U12; and late: U100) were selected as targets...
May 23, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28542724/viruses-and-endogenous-retroviruses-in-multiple-sclerosis-from-correlation-to-causation
#12
REVIEW
A-F A Mentis, E Dardiotis, N Grigoriadis, E Petinaki, G M Hadjigeorgiou
Multiple sclerosis is an immune-mediated disease with an environmental component. According to a long-standing but unproven hypothesis dating to initial descriptions of multiple sclerosis (MS) at the end of the 19th century, viruses are either directly or indirectly implicated in MS pathogenesis. Whether viruses in MS are principally causal or simply contributory remains to be proven, but many viruses or viral elements-predominantly Epstein-Barr virus, human endogenous retroviruses (HERVs) and human herpesvirus 6 (HHV-6) but also less common viruses such as Saffold and measles viruses-are associated with MS...
May 23, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28501929/hyponatremia-associated-with-human-herpesvirus-6-hhv-6-encephalitis-after-allogeneic-hematopoietic-stem-cell-transplantation-a-presentation-different-from-hhv-6-myelitis
#13
Koichi Murakami, Sumiko Kohashi, Masatoshi Sakurai, Jun Kato, Takaaki Toyama, Yuya Koda, Yusuke Yamane, Risa Hashida, Ryohei Abe, Rie Yamazaki, Taku Kikuchi, Takayuki Shimizu, Shigeaki Suzuki, Naoki Hasegawa, Shinichiro Okamoto, Takehiko Mori
Human herpesvirus-6 (HHV-6) encephalitis and myelitis following allogeneic hematopoietic stem cell transplantation (HSCT) is frequently life-threatening. We retrospectively evaluated the clinical significance of hyponatremia in cases of HHV-6 encephalitis/myelitis. Using an institutional database and medical records, we identified and retrospectively analyzed 16 cases of HHV-6 encephalitis and/or myelitis after allogeneic HSCT. HHV-6 encephalitis and myelitis were defined as the symptoms/signs with HHV-6-DNA in the cerebrospinal fluid...
May 13, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28480161/multiple-cavities-with-halo-sign-in-a-case-of-invasive-pulmonary-aspergillosis-during-therapy-for-drug-induced-hypersensitivity-syndrome
#14
Tomoo Ikari, Katsura Nagai, Masashi Ohe, Toshiyuki Harada, Yasushi Akiyama
A 67-year-old female with rheumatoid arthritis and asthma-chronic obstructive pulmonary disease overlap syndrome was admitted for drug-induced hypersensitivity syndrome (DIHS) caused by salazosulfapyridine. Human herpes virus 6 (HHV-6) variant B was strongly positive on peripheral blood. Multiple cavities with ground grass opacities rapidly emerged predominantly in the upper and middle lobes. She was diagnosed with invasive pulmonary aspergillosis (IPA), and was treated successfully with antifungal agents. Therapeutic systemic corticosteroids, emphysematous change in the lungs, and the worsening of the patient's general condition due to DIHS were considered major contributing factor leading to IPA...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28478829/the-use-of-heparin-in-infertility-and-recurrent-pregnancy-loss-are-its-antiviral-properties-at-play
#15
Eva Eliassen, Roberto Marci, Dario Di Luca, Roberta Rizzo
Recently, human herpesvirus 6 (HHV-6) has been implicated in cases of poor pregnancy outcomes. The ability of HHV-6 to disrupt endothelial cell functioning may inhibit the creation of an appropriate uterine environment for implantation and fetal development, resulting in infertility and pregnancy loss, among other complications. Heparin has been used to treat pregnant women who are predisposed to thrombosis, and it has also been used in some women with infertility or recurrent pregnancy loss without associated thrombotic events...
May 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28476346/comparative-evaluation-of-a-laboratory-developed-real-time-pcr-assay-and-the-realstar-%C3%A2-hhv-6-pcr-kit-for-quantitative-detection-of-human-herpesvirus-6
#16
Cyril C Y Yip, Siddharth Sridhar, Andrew K W Cheng, Ami M Y Fung, Vincent C C Cheng, Kwok-Hung Chan, Kwok-Yung Yuen
BACKGROUND: HHV-6 reactivation in immunocompromised patients is common and may be associated with serious morbidity and mortality; therefore, early detection and initiation of therapy might be of benefit. Real-time PCR assays allow for early identification of HHV-6 reactivation to assist in providing a timely response. Thus, we compared the performance of an in-house developed HHV-6 quantitative PCR assay with a commercially available kit, the RealStar(®) HHV-6 PCR Kit. METHOD: The analytical sensitivity, analytical specificity, linearity, precision and accuracy of the in-house developed HHV-6 qPCR assay were evaluated...
May 2, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28469695/molecular-diagnosis-of-central-nervous-system-opportunistic-infections-and-mortality-in-hiv-infected-adults-in-central-china
#17
Rongrong Yang, Hong Zhang, Yong Xiong, Xien Gui, Yongxi Zhang, Liping Deng, Shicheng Gao, Mingqi Luo, Wei Hou, Deyin Guo
BACKGROUND: CSF PCR is the standard diagnostic technique used in resource-rich settings to detect pathogens of the CNS infection. However, it is not currently used for routine CSF testing in China. Knowledge of CNS opportunistic infections among people living with HIV in China is limited. METHODS: Intensive cerebrospiral fluid (CSF) testing was performed to evaluate for bacterial, viral and fungal etiologies. Pathogen-specific primers were used to detect DNA from cytomegalovirus (CMV), herpes simplex virus (HSV), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), human herpesvirus 6 (HHV-6) and John Cunningham virus (JCV) via real-time polymerase chain reaction (PCR)...
2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28468887/stabilization-of-telomere-g-quadruplexes-interferes-with-human-herpesvirus-6a-chromosomal-integration
#18
Shella Gilbert-Girard, Annie Gravel, Sara Artusi, Sara N Richter, Nina Wallaschek, Benedikt B Kaufer, Louis Flamand
Human herpesviruses 6A and 6B (HHV-6A/B) can integrate their genomes into the telomeres of human chromosomes using a mechanism that remains poorly understood. To achieve a better understanding of the HHV-6A/B integration mechanism, we made use of BRACO-19, a compound that stabilizes G-quadruplex secondary structures and prevents telomere elongation by the telomerase complex. First, we analyzed the folding of telomeric sequences into G-quadruplex structures and their binding to BRACO-19 using G-quadruplex-specific antibodies and surface plasmon resonance...
July 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28464834/molecular-diagnosis-of-central-nervous-system-opportunistic-infections-and-mortality-in-hiv-infected-adults-in-central-china
#19
Rongrong Yang, Hong Zhang, Yong Xiong, Xien Gui, Yongxi Zhang, Liping Deng, Shicheng Gao, Mingqi Luo, Wei Hou, Deyin Guo
BACKGROUND: CSF PCR is the standard diagnostic technique used in resource-rich settings to detect pathogens of the CNS infection. However, it is not currently used for routine CSF testing in China. Knowledge of CNS opportunistic infections among people living with HIV in China is limited. METHODS: Intensive cerebrospiral fluid (CSF) testing was performed to evaluate for bacterial, viral and fungal etiologies. Pathogen-specific primers were used to detect DNA from cytomegalovirus (CMV), herpes simplex virus (HSV), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), human herpesvirus 6 (HHV-6) and John Cunningham virus (JCV) via real-time polymerase chain reaction (PCR)...
May 2, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28398495/a-histological-study-of-fulminant-type-1-diabetes-mellitus-related-to-human-cytomegalovirus-reactivation
#20
Sho Yoneda, Akihisa Imagawa, Kenji Fukui, Sae Uno, Junji Kozawa, Makoto Sakai, Toshiki Yumioka, Hiromi Iwahashi, Iichiro Shimomura
Context: Fulminant type 1 diabetes mellitus (T1DM) is thought to be partly caused by virus infection. Objective: This study investigated the mechanism of β cell destruction in fulminant T1DM after drug-induced hypersensitivity syndrome (DIHS). Methods: We determined the localization of viruses of human cytomegalovirus (HCMV), human herpesvirus 6 (HHV-6) and Epstein-Barr virus (EBV), and the expression of interferon regulatory factor 3 (IRF3) and viral receptors of Z DNA binding protein 1 (ZBP1) and retinoic acid-inducible gene I (RIG-I), together with inflammatory cells by immunohistochemistry of pancreas from an autopsy fulminant T1DM patient with DIHS or seven subjects with normal glucose tolerance who underwent pancreatectomy...
April 10, 2017: Journal of Clinical Endocrinology and Metabolism
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