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https://www.readbyqxmd.com/read/28092892/deformation-of-erythroblasts-in-transient-erythroblastopenia-of-childhood-caused-by-hhv-6
#1
Akira Ogawa, Ryu Yanagisawa
No abstract text is available yet for this article.
June 2, 2016: Blood
https://www.readbyqxmd.com/read/28078864/human-herpesviruses-6-and-7-encephalitis-in-immunocompetent-infants-are-they-really-so-uncommon
#2
L Marseglia, S Manti, G D Angelo, G Stroscio, D Impollonia, S Arena, C Salpietro, E Gitto
Human herpesviruses-6 and -7 (HHV-6 and 7) are considered uncommon causes of central nervous system infection and may occasionally cause encephalitis in young infants, however, the clinical syndrome and incidence are not well defined. In immunosuppressed hosts, reactivation is associated with a worse outcome such as encephalitis, hepatitis, or graft rejection. In immunocompetent hosts, this persistent infection is generally of no consequence. We report 4 cases of immunocompetent critically ill children, affected by HHV-6 and -7 encephalitis, admitted to our Pediatric Intensive Care Unit...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28072884/structural-and-ultrastructural-alterations-in-human-olfactory-pathways-and-possible-associations-with-herpesvirus-6-infection
#3
Sandra Skuja, Anete Zieda, Kristine Ravina, Svetlana Chapenko, Silvija Roga, Ojars Teteris, Valerija Groma, Modra Murovska
Structural and ultrastructural alterations in human olfactory pathways and putative associations with human herpesvirus 6 (HHV-6) infection were studied. The olfactory bulb/tract samples from 20 subjects with an unspecified encephalopathy determined by pathomorphological examination of the brain autopsy, 17 healthy age-matched and 16 younger controls were used. HHV-6 DNA was detected in 60, 29, and 19% of cases in these groups, respectively. In the whole encephalopathy group, significantly more HHV-6 positive neurons and oligodendrocytes were found in the gray matter, whereas, significantly more HHV-6 positive astrocytes, oligodendrocytes, microglia/macrophages and endothelial cells were found in the white matter...
2017: PloS One
https://www.readbyqxmd.com/read/28051106/u24-from-roseolovirus-interacts-strongly-with-nedd4-ww-domains
#4
Yurou Sang, Rui Zhang, Walter R P Scott, A Louise Creagh, Charles A Haynes, Suzana K Straus
U24 is a protein found in both roseoloviruses Human Herpes Virus type 6 and 7 (HHV-6 and HHV-7), with an N-terminus that is rich in prolines (PY motif in both HHV-6A and 7; PxxP motif in HHV-6A). Previous work has shown that the interaction between U24 and WW domains is important for endocytic recycling of T-cell receptors, but a cognate ligand was never identified. In this contribution, data was obtained from pull-downs, ITC, NMR and molecular dynamics simulations to show that a specific interaction exists between U24 and Nedd4 WW domains...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28008656/human-herpesvirus-6-hhv-6b-lymphadenitis-in-dress-syndrome-a-lymphoma-mimic
#5
Steven Johnson, Stephanie Mathews, David S Hudnall
AIMS: Lymphadenopathy, hematologic abnormalities, and constitutional symptoms are among the non-specific manifestations seen in drug rash with eosinophilia and systemic symptoms (DRESS), an uncommon but potentially fatal cutaneous adverse drug reaction. The ubiquitous human herpesvirus 6 (HHV-6) plays a unique role in the pathogenesis of DRESS, with emerging data suggesting that reactivation occurs in most cases and contributes to the clinical manifestations, including lymphadenopathy...
December 23, 2016: Histopathology
https://www.readbyqxmd.com/read/28005515/possible-chromosomal-and-germline-integration-of-human-herpesvirus-7-hhv-7
#6
Bhupesh K Prusty, Nitish Gulve, Santa Rasa, Modra Murovska, Pilar Collado Hernandez, Dharam V Ablashi
Human herpesvirus 7 (HHV-7) is a betaherpesvirus and is phylogenetically related to both HHV-6A and HHV-6B. The presence of telomeric repeat sequences at both end of its genome should make it equally likely to integrate into human telomere as HHV-6. However, numerous studies have failed to detect germline integration of HHV-7 suggesting an important difference between the HHV-6A/-6B and HHV-7 genomes. In search of possible germline integrated HHV-7, we developed a sensitive and quantitative real time PCR assay and discovered that primers designed against some parts of HHV-7 genome can frequently miss HHV-7 positive clinical samples even though they work efficiently in cell culture derived HHV-7 positive materials...
December 21, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27928011/high-prevalence-of-infectious-adeno-associated-virus-aav-in-human-peripheral-blood-mononuclear-cells-indicative-of-t-lymphocytes-as-sites-of-aav-persistence
#7
Daniela Hüser, Dina Khalid, Timo Lutter, Eva-Maria Hammer, Stefan Weger, Melanie Heßler, Ulrich Kalus, Yvonne Tauchmann, Karin Hensel-Wiegel, Dirk Lassner, Regine Heilbronn
: Seroepidemiology shows that infections with adeno-associated virus (AAV) are widespread, but diverse AAV serotypes isolated from man or non-human primates have so far not been proven as causes of human disease. In view of the increasing success of AAV-derived vectors in human gene therapy, the definition of the in vivo sites of wild-type AAV persistence and clinical consequences of its reactivation are becoming increasingly urgent.Here, we identified the presumed cell-type for AAV persistence in the human host, by highly sensitive AAV PCRs developed for the full spectrum of human AAV serotypes...
December 7, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27902331/the-plasma-virome-of-febrile-adult-kenyans-shows-frequent-parvovirus-b19-infections-and-a-novel-arbovirus-kadipiro-virus
#8
Carolyne N Ngoi, Juliana Siqueira, Linlin Li, Xutao Deng, Peter Mugo, Susan M Graham, Matt A Price, Eduard J Sanders, Eric Delwart
Viral nucleic acids present in the plasma of 498 Kenyan adults with unexplained fever were characterized by metagenomics analysis of 51 sample pools. The highest to lowest fraction of plasma pools was positive for parvovirus B19 (75 %), pegivirus C (GBV-C) (67 %), alpha anellovirus (59 %), gamma anellovirus (55 %), beta anellovirus (41 %), dengue virus genotype 2 (DENV-2) (16 %), human immunodeficiency virus type 1 (6 %), human herpesvirus 6 (6 %), HBV (4 %), rotavirus (4 %), hepatitis B virus (4 %), rhinovirus C (2 %), Merkel cell polyomavirus (MCPyV; 2 %) and Kadipiro virus (2 %)...
December 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27885344/drug-induced-hypersensitivity-syndrome-caused-by-carbamazepine-used-for-the-treatment-of-trigeminal-neuralgia
#9
Yuko Ono, Tsuyoshi Shimo, Yoshinori Shirafuji, Toshihisa Hamada, Masanori Masui, Kyoichi Obata, Mayumi Yao, Koji Kishimoto, Akira Sasaki
An 88-year-old man was diagnosed with trigeminal neuralgia, and treatment of carbamazepine 200 mg/day was initiated. About 6 weeks later, the patient developed a skin rash accompanied by fever. He was admitted to hospital and diagnosed with drug-induced hypersensitivity syndrome (DIHS) caused by carbamazepine. Oral carbamazepine treatment was stopped, but blood tests showed acute liver and acute renal failure. Drug-induced lymphocyte stimulation test (DLST) for carbamazepine, human herpes virus-6 (HHV-6) IgG, and CMV-HRP were negative...
2016: Case Reports in Dentistry
https://www.readbyqxmd.com/read/27862208/cytokine-and-cellular-responses-to-human-herpesvirus-6b-in-patients-with-b-acute-lymphoblastic-leukemia
#10
Faten Nefzi, Claude Lambert, Agnès Gautheret-Dejean, Sylvain Fisson, Quentin Khebizi, Abderrahim Khelif, Henri Agut, Mahjoub Aouni
Primary infection with human herpesvirus-6 (HHV-6), is followed by its lifelong persistence in the host. Most T-cell responses to HHV-6 have been characterized using peripheral blood from healthy adults; however, the role of HHV-6 infection in immune modulation has not been elucidated for some diseases. Therefore, in this study the immune response to HHV-6 infection in patients with B-acute lymphoblastic leukemia (B-ALL) was analyzed. HHV-6 load was quantified in blood samples taken at the time of diagnosis of leukemia and on remission...
November 2016: Microbiology and Immunology
https://www.readbyqxmd.com/read/27859994/transmission-of-chromosomally-integrated-human-herpesvirus-6-via-cord-blood-transplantation
#11
Yuji Yamada, Tomoo Osumi, Ken-Ichi Imadome, Etsuko Takahashi, Tamae Ohye, Tetsushi Yoshikawa, Daisuke Tomizawa, Motohiro Kato, Kimikazu Matsumoto
Chromosomally integrated human herpesvirus 6 (ciHHV-6) can be transmitted via allogeneic hematopoietic cell transplantation. To date, only a few cases have been reported. Here, we report a case identified as transmission of ciHHV-6 via cord blood transplantation. Distinguishing transmission of ciHHV-6 from HHV-6 reactivation in cases with high titer of HHV-6 DNA load after transplantation is important to prevent unnecessary exposure to antiviral drugs that could be toxic.
November 16, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/27830722/comprehensive-polymerase-chain-reaction-assay-for-detection-of-pathogenic-dna-in-lymphoproliferative-disorders-of-the-ocular-adnexa
#12
Yoshihiko Usui, Narsing A Rao, Hiroshi Takase, Kinya Tsubota, Kazuhiko Umazume, Daniel Diaz-Aguilar, Takeshi Kezuka, Manabu Mochizuki, Hiroshi Goto, Sunao Sugita
Infectious agents have been identified as a major cause of specific types of human cancers worldwide. Several microorganisms have been identified as potential aggravators of ocular adnexal neoplasms; however, given the rarity of these neoplasms, large epidemiological studies are difficult to coordinate. This study aimed to conduct an exhaustive search for pathogenic DNA in lymphoproliferative disorders (LPD) of the ocular adnexa in a total of 70 patients who were diagnosed with LPD of the ocular adnexa between 2008 and 2013...
November 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27800078/-molecular-tests-in-diagnosis-of-cytomegalovirus-cmv-human-herpesvirus-6-hhv-6-and-epstein-barr-virus-ebv-using-real-time-pcr-in-hiv-positive-and-hiv-negative-pregnant-women-in-ouagadougou-burkina-faso
#13
Alice Rogomenoma Ouedraogo, Madeleine Kabre, Cyrille Bisseye, Théodora Mahoukèdè Zohoncon, Maleki Asshi, Serge Théophile Soubeiga, Birama Diarra, Lassina Traore, Florencia Wendkuuni Djigma, Djénéba Ouermi, Virginio Pietra, Nicolas Barro, Jacques Simpore
INTRODUCTION: Herpesvirus EBV, CMV and HHV-6 are viruses that evolve based on pandemic modeling and are responsible for congenital infections causing severe sequelae in infants. This study aims to determine the prevalence of CMV, EBV and HHV-6 among HIV (+) and HIV (-) pregnant women in Ouagadougou. METHODS: In this study 200 blood plasma samples taken from pregnant women, of whom 100 with HIV(+) and 100 with HIV(-), were analyzed using multiplex real-time PCR which detected three infections (EBV, CMV and HHV-6)...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27777240/inherited-chromosomally-integrated-human-herpesvirus-6-and-breast-cancer
#14
Annie Gravel, Isabelle Dubuc, Angela Brooks-Wilson, Kristan J Aronson, Jacques Simard, Hector Velasquez-Garcia, John J Spinelli, Louis Flamand
Background Inherited chromosomally-integrated human herpesvirus 6 (iciHHV-6) is a condition observed in approximately 1% of the population. Whether such a genetic alteration predisposes to cancer development in currently unknown. Two studies were conducted to determine whether iciHHV-6 is associated with cancer development. Methods First, a screen of 19,597 people from the province of Quebec was conducted. A replication test, using data from a population-based case-control study of 1090 women with incident breast cancer and 1053 controls from British Columbia and Ontario was conducted...
October 24, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27772620/cytomegalovirus-and-other-%C3%AE-herpesviruses
#15
REVIEW
Carlos A Q Santos
Cytomegalovirus (CMV), human herpes virus (HHV)-6, and HHV-7 are ubiquitous β-herpesviruses that can cause opportunistic infection and disease in kidney transplant recipients. Active CMV infection and disease are associated with acute allograft failure and death, and HHV-6 and HHV-7 replication are associated with CMV disease. CMV prevention strategies are used commonly after kidney transplantation, and include prophylaxis with antiviral medications and preemptive treatment upon the detection of asymptomatic viral replication in blood...
September 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27703035/cd4-t-cells-coexpressing-cd134-ox40-harbor-significantly-increased-levels-of-human-herpesvirus-6b-dna-following-umbilical-cord-blood-transplantation
#16
Joshua C Pritchett, Jaime S Green, Angela M Thomm, Konstance K Knox, Michael R Verneris, Troy C Lund
Human herpesvirus 6B (HHV-6B) commonly reactivates after umbilical cord blood transplantation (UCBT) and is associated with delayed engraftment, fever, rash, and central nervous system dysfunction. Recently, CD134 (OX40) has been implicated as a potential viral entry receptor. We evaluated CD4(+)CD134(+)/(neg-lo) and CD8(+)CD134(+)/(neg-lo) cells at day 28 after UCBT in 20 subjects with previously documented HHV-6 reactivation and persistent viremia. Analysis of CD4(+)CD134(+) cells as compared to CD4(+)CD134(neg-lo) cells showed 0...
December 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27697585/human-herpesvirus-6-infection-following-haploidentical-transplantation-immune-recovery-and-outcome
#17
Raffaella Greco, Lara Crucitti, Maddalena Noviello, Sara Racca, Daniele Mannina, Alessandra Forcina, Francesca Lorentino, Veronica Valtolina, Serena Rolla, Roee Dvir, Mara Morelli, Fabio Giglio, Maria Chiara Barbanti, Maria Teresa Lupo Stanghellini, Chiara Oltolini, Luca Vago, Paolo Scarpellini, Andrea Assanelli, Matteo G Carrabba, Sarah Marktel, Massimo Bernardi, Consuelo Corti, Massimo Clementi, Jacopo Peccatori, Chiara Bonini, Fabio Ciceri
Human herpesvirus 6 (HHV-6) is increasingly recognized as a potentially life-threatening pathogen in allogeneic hematopoietic stem cell transplantation (alloSCT). We retrospectively evaluated 54 adult patients who developed positivity to HHV-6 after alloSCT. The median time from alloSCT to HHV-6 reactivation was 34 days. HHV-6 was present in plasma samples from 31 patients, in bone marrow (BM) of 9 patients, in bronchoalveolar lavage fluid and liver or gut biopsy specimens from 33 patients, and in cerebrospinal fluid of 7 patients...
September 30, 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27694307/distribution-and-effects-of-amino-acid-changes-in-drug-resistant-%C3%AE-and-%C3%AE-herpesviruses-dna-polymerase
#18
D Topalis, S Gillemot, R Snoeck, G Andrei
Emergence of drug-resistance to all FDA-approved antiherpesvirus agents is an increasing concern in immunocompromised patients. Herpesvirus DNA polymerase (DNApol) is currently the target of nucleos(t)ide analogue-based therapy. Mutations in DNApol that confer resistance arose in immunocompromised patients infected with herpes simplex virus 1 (HSV-1) and human cytomegalovirus (HCMV), and to lesser extent in herpes simplex virus 2 (HSV-2), varicella zoster virus (VZV) and human herpesvirus 6 (HHV-6). In this review, we present distinct drug-resistant mutational profiles of herpesvirus DNApol...
November 16, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27693656/association-of-active-human-herpesvirus-6-hhv-6-infection-with-autoimmune-thyroid-gland-diseases
#19
A Sultanova, M Cistjakovs, S Gravelsina, S Chapenko, S Roga, E Cunskis, Z Nora-Krukle, V Groma, I Ventina, M Murovska
OBJECTIVES: Viral infections frequently have been cited as important environmental factors implicated in the onset of autoimmune thyroiditis (AIT). The aim of this study was to determine the involvement of HHV-6 infection in the development of autoimmune thyroiditis. METHODS: This study included 45 patients (42 female and 3 male; median age 47.00 IQR 38.50-57.00) with histologically, laboratory, and clinically confirmed autoimmune thyroiditis, as well as 30 autopsied subjects (26 female and 4 male; median age 58...
September 30, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27669362/human-herpesvirus-6-replication-predicts-cytomegalovirus-reactivation-after-allogeneic-stem-cell-transplantation-from-haploidentical-donor
#20
Roberto Crocchiolo, Laura Giordano, Andrea Rimondo, Muriel Bologna, Barbara Sarina, Lucio Morabito, Stefania Bramanti, Luca Castagna, Rossana Mineri
BACKGROUND AND OBJECTIVES: Since HHV-6 reactivation after transplant has been reported to increase the risk of CMV infection, we tested this hypothesis in the HLA-haploidentical hematopoietic stem cell transplantation setting. STUDY DESIGN: From February 2011 to October 2015, 75 patients received hematopoietic stem cell transplantation using a T-cell replete graft from a HLA-haploidentical donor at our Institution. RESULTS: Interestingly, 87% of HHV-6 reactivations were followed by a CMV reactivation, at a median of 15days between the two viruses...
November 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
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