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https://www.readbyqxmd.com/read/29143761/antibody-cross-reactivity-between-porcine-cytomegalovirus-pcmv-and-human-herpesvirus-6-hhv-6
#1
Uwe Fiebig, Angela Holzer, Daniel Ivanusic, Elena Plotzki, Hartmut Hengel, Frank Neipel, Joachim Denner
Porcine cytomegalovirus (PCMV) infection is widely prevalent among pigs, and PCMV is one of the viruses which may be transmitted during xenotransplantation using pig cells, tissues, or organs. While human cytomegalovirus (HCMV) is a major risk factor for allotransplantation, it is still unclear whether PCMV is able to infect human cells or pose a risk for xenotransplantation. Previously, it was shown that transmission of PCMV after pig kidney to non-human primate transplantations resulted in a significantly reduced survival time of the transplanted organ...
October 28, 2017: Viruses
https://www.readbyqxmd.com/read/29076102/epidemiological-profile-of-acute-viral-encephalitis
#2
Rajesh Kumar, Pankaj Kumar, Manoj Kumar Singh, Dipti Agarwal, Bendangienla Jamir, Shashi Khare, Samrendra Narayan
OBJECTIVE: To study the etiology and clinico-epidemiological profile of acute viral encephalitis in children with acute encephalitis syndrome (AES). METHODS: An observational study including 100 patients fulfilling the criteria for AES was conducted in children of age group 1 mo - 16 y. Viral isolation was done on RD cells, HEp-2 cells and Vero cells from the cerebrospinal fluid samples of suspected viral encephalitis (VE) cases. An enzyme immunoassay for IgM antibodies was performed for measles, mumps, Varicella zoster virus (VZV), Herpes simplex virus 1 (HSV1) and Japanese encephalitis virus (JEV)...
October 27, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29066274/self-healing-juvenile-cutaneous-mucinosis-clinical-and-histopathologic-findings-of-nine-cases-the-relevance-of-long-term-follow-up
#3
Isabelle Luchsinger, Jérôme Coulombe, Franco Rongioletti, Marc Haspeslagh, Anne Dompmartin, Isabelle Melki, Rawane Dagher, Brigitte Bader-Meunier, Sylvie Fraitag, Christine Bodemer
BACKGROUND: Self-healing juvenile cutaneous mucinosis (SHJCM) is a rare disorder and the pathogenesis and long-term prognosis are unknown. OBJECTIVES: To elucidate the clinical and histopathologic characteristics, pathogenesis and outcome in patients with SHJCM. METHODS: Retrospective study of 9 patients with SHCJM. To complement initial findings, data collection forms were sent to the referring physicians. RESULTS: All patients had an acute onset of firm nodules...
October 21, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29026166/virus-and-host-specific-differences-in-oral-human-herpesvirus-shedding-kinetics-among-ugandan-women-and-children
#4
Laura Matrajt, Soren Gantt, Bryan T Mayer, Elizabeth M Krantz, Jackson Orem, Anna Wald, Lawrence Corey, Joshua T Schiffer, Corey Casper
Human herpesviruses (HHV) establish lifelong latent infection and are transmitted primarily via shedding at mucosal surfaces. Each HHV causes a unique spectrum of disease depending on the infected individual's age and immunity. We collected weekly oral swabs from young children and mothers in 32 Ugandan households for a median of one year. We characterized kinetics of oral shedding during primary and chronic infection for each virus. Cytomegalovirus (CMV), Epstein-Barr virus (EBV), and HHV-6 were shed at high rates following primary infection...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29022282/analysis-of-five-cases-of-human-herpesvirus-6-myelitis-among-121-cord-blood-transplantations
#5
Toshimitsu Ueki, Kenichi Hoshi, Yuki Hiroshima, Masahiko Sumi, Naoaki Ichikawa, Masao Ogata, Takako Satou, Takahiro Fukuda, Hikaru Kobayashi
Reports of myelitis associated with human herpesvirus-6 (HHV-6) following allogeneic transplantation are rare. Of 121 cases of cord blood transplantation (CBT) performed at Nagano Red Cross Hospital, five cases (4.1%) of HHV-6 myelitis developed at around the time of engraftment. The major symptom identified in all five patients was superficial pain or pruritus linked to segmental levels of the spinal cord. Other identified symptoms were fever or low-grade fever in all five patients, autonomic nerve disorder in four patients, bladder and rectal disturbance in two patients, and extrapyramidal disorder in two patients...
October 11, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28980591/-the-role-of-persistent-viral-infections-with-herpes-viridae-and-papilloma-viridae-associated-with-chronic-inflammatory-pathology-of-the-oropharynx
#6
N D Yushchuk, A I Kryukov, A B Turovsky, I A Popova, M V Savostikova
The high prevalence of chronic inflammatory oropharyngeal pathologies and a large variety of specific pathogenetic features of the persistent viral infections caused by the species of the families Herpesviridae and Papillomaviridae as etiological agents of the disease suggest the necessity of investigations with a view to evaluating the clinical significance of persistent viral infections with Herpesviridae and Papillomaviridae species in the patients presenting with chronic inflammatory oropharyngreal pathology...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28958731/brainstem-infarction-associated-with-hhv-6-infection-in-an-infant
#7
Aya Wada, Kazuhiro Muramatsu, Yasuo Sunaga, Takahisa Mizuno, Mariko Takei, Satoshi Ogasawara, Miho Uchida, Kiwako Tsukida, Masahiko Tashiro
INTRODUCTION: The relevant literature includes several case reports on cerebral infarction in children with HHV-6 infection; however, there is no report of brain stem infarction. CASE: An 11-month-old girl was hospitalized because of fever. She was unable to stand up and meet her mother's gaze. Magnetic resonance imaging (MRI) indicated a right pons and mid-brain lesion; a diagnosis of brainstem infarction was made. After her fever subsided, a rash developed on her trunk and limbs; blood examination results indicated a primary HHV-6 infection...
September 25, 2017: Brain & Development
https://www.readbyqxmd.com/read/28928612/human-herpesvirus-6-induced-inflammatory-cardiomyopathy-in-immunocompetent-children
#8
REVIEW
Surabhi Reddy, Eva Eliassen, Gerhard R Krueger, Bibhuti B Das
Over the last decade, human herpesvirus 6 (HHV-6) has been implicated in the etiology of pediatric myocarditis and subsequent dilated cardiomyopathy (DCM). This review provides an overview of recent literature investigating the pathophysiological relevance of HHV-6 in inflammatory cardiomyopathy. We examined 11 cases of previously published pediatric myocarditis and/or DCM associated with HHV-6 and also our experience of detection of virus particles in vascular endothelium of HHV-6 positive endomyocardial biopsy tissue by electron microscopy...
September 2017: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/28902954/predominant-contribution-of-cd4-t-cells-to-human-herpesvirus-6-hhv-6-load-in-the-peripheral-blood-of-patients-with-drug-induced-hypersensitivity-syndrome-and-persistent-hhv-6-infection
#9
Fumi Miyagawa, Yuki Nakamura, Rie Ommori, Kazuya Miyashita, Hiroshi Iioka, Natsuki Miyashita, Mitsuko Nishikawa, Yukiko Himuro, Kohei Ogawa, Hideo Asada
No abstract text is available yet for this article.
September 13, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28902907/pcr-detection-of-human-herpesviruses-in-colonic-mucosa-of-individuals-with-inflammatory-bowel-disease-comparison-with-individuals-with-immunocompetency-and-hiv-infection
#10
COMPARATIVE STUDY
Takayuki Shimada, Naoyoshi Nagata, Koki Okahara, Akane Joya, Tsunefusa Hayashida, Shinichi Oka, Toshiyuki Sakurai, Junichi Akiyama, Naomi Uemura, Hiroyuki Gatanaga
BACKGROUND: Detection of human herpesviruses (HHVs) other than cytomegalovirus (CMV) in colonic mucosa of individuals with inflammatory bowel disease (IBD) remains unknown. This study identified eight HHVs in the colonic mucosa of individuals with IBD and compared the results with immunocompetent and human immunodeficiency virus (HIV)-infected individuals. METHODS: A total of 89 individuals who had colorectal ulcer on colonoscopy were enrolled: 26 with immunocompetency (n = 26), 41 with IBD, and 22 with HIV infection...
2017: PloS One
https://www.readbyqxmd.com/read/28894558/ebv-and-hhv-6-circulating-subtypes-in-people-living-with-hiv-in-burkina-faso-impact-on-cd4-t-cell-count-and-hiv-viral-load
#11
Lassina Traore, Ouéogo Nikiema, Abdoul Karim Ouattara, Tegwindé Rébéca Compaore, Serge Théophile Soubeiga, Birama Diarra, Dorcas Obiri-Yeboah, Pegdwendé Abel Sorgho, Florencia Wendkuuni Djigma, Cyrille Bisseye, Albert Théophane Yonli, Jacques Simpore
Epstein Barr Virus (EBV) and Human Herpes Virus 6 (HHV-6) are responsible for severe diseases, particularly in immunocompromised persons. There is limited data of the infection of these opportunistic viruses in Burkina Faso. The purpose of this study was to characterize EBV and HHV-6 subtypes and to assess their impact on CD4 T cell count, HIV-1 viral load and antiretroviral treatment in people living with HIV-1. The study population consisted of 238 HIV-positive patients with information on the CD4 T cell count, HIV-1 viral load and HAART...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/28838940/chromosomally-integrated-hhv-6-a-new-piece-of-the-puzzle
#12
Per Ljungman
No abstract text is available yet for this article.
August 24, 2017: Blood
https://www.readbyqxmd.com/read/28835501/inherited-chromosomally-integrated-human-herpesvirus-6-genomes-are-ancient-intact-and-potentially-able-to-reactivate-from-telomeres
#13
Enjie Zhang, Adam J Bell, Gavin S Wilkie, Nicolás M Suárez, Chiara Batini, Colin D Veal, Isaac Armendáriz-Castillo, Rita Neumann, Victoria E Cotton, Yan Huang, David J Porteous, Ruth F Jarrett, Andrew J Davison, Nicola J Royle
The genomes of human herpesvirus 6A (HHV-6A) and HHV-6B have the capacity to integrate into telomeres, the essential capping structures of chromosomes that play roles in cancer and ageing. About 1% of people worldwide are carriers of chromosomally integrated HHV-6 (ciHHV-6), which is inherited as a genetic trait. Understanding the consequences of integration for the evolution of the viral genome, for the telomere, and for the risk of disease associated with carrier status is hampered by a lack of knowledge about ciHHV-6 genomes...
November 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28822107/successful-treatment-and-fdg-pet-ct-monitoring-of-hhv-6-encephalitis-in-a-non-neutropenic-patient-case-report-and-literature-review
#14
Elda Righi, Alessia Carnelutti, Daniele Muser, Francesco Zaja, Elisa Lucchini, Federico Pea, Fernando Di Gregorio, Abass Alavi, Matteo Bassetti
Human herpesvirus (HHV)-6 reactivation is associated with severe forms of encephalitis among patients undergoing hematopoietic stem cell transplantation. Cases in non-neutropenic patients are uncommon. The efficacy of ganciclovir and other compounds that are used for the treatment of HHV-6 encephalitis remains suboptimal and linked to toxicity. Valganciclovir, the oral prodrug of ganciclovir, could be practical to treat outpatients, but it is not commonly used for severe cases. We report a case of HHV-6 encephalitis in a non-neutropenic patient successfully treated with valganciclovir and undergoing therapeutic drug monitoring in plasma and in the cerebrospinal fluid...
August 18, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28801087/cause-of-acute-encephalitis-encephalopathy-in-japanese-children-diagnosed-by-a-rapid-and-comprehensive-virological-detection-system-and-differences-in-their-clinical-presentations
#15
Kei Takasawa, Ryuichi Nakagawa, Shigeru Takishima, Kengo Moriyama, Ken Watanabe, Koji Kiyohara, Takeshi Hasegawa, Masahiro Shimohira, Kenichi Kashimada, Norio Shimizu, Tomohiro Morio
BACKGROUND: Acute encephalitis/encephalopathy (AE/E) is a rare and severe complication of common childhood infections; however, a treatment strategy based on clinical and pathological evidence has not been established. METHODS: The clinical data and aetiological results using a rapid and comprehensive virological detection system of 62 Japanese children diagnosed with AE/E from 2010 to 2014 were collected. We assessed clinical differences between causes and effectiveness of our multiplex PCR system to establish a pathogen-based treatment strategy for AE/E...
August 8, 2017: Brain & Development
https://www.readbyqxmd.com/read/28783452/off-the-shelf-virus-specific-t-cells-to-treat-bk-virus-human-herpesvirus-6-cytomegalovirus-epstein-barr-virus-and-adenovirus-infections-after-allogeneic-hematopoietic-stem-cell-transplantation
#16
Ifigeneia Tzannou, Anastasia Papadopoulou, Swati Naik, Kathryn Leung, Caridad A Martinez, Carlos A Ramos, George Carrum, Ghadir Sasa, Premal Lulla, Ayumi Watanabe, Manik Kuvalekar, Adrian P Gee, Meng-Fen Wu, Hao Liu, Bambi J Grilley, Robert A Krance, Stephen Gottschalk, Malcolm K Brenner, Cliona M Rooney, Helen E Heslop, Ann M Leen, Bilal Omer
Purpose Improvement of cure rates for patients treated with allogeneic hematopoietic stem-cell transplantation (HSCT) will require efforts to decrease treatment-related mortality from severe viral infections. Adoptively transferred virus-specific T cells (VSTs) generated from eligible, third-party donors could provide broad antiviral protection to recipients of HSCT as an immediately available off-the-shelf product. Patient and Methods We generated a bank of VSTs that recognized five common viral pathogens: Epstein-Barr virus (EBV), adenovirus (AdV), cytomegalovirus (CMV), BK virus (BKV), and human herpesvirus 6 (HHV-6)...
November 1, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28783148/clinical-characteristics-and-outcome-of-human-herpesvirus-6-encephalitis-after-allogeneic-hematopoietic-stem-cell-transplantation
#17
M Ogata, K Oshima, T Ikebe, K Takano, H Kanamori, T Kondo, Y Ueda, T Mori, H Hashimoto, H Ogawa, T Eto, T Ueki, T Miyamoto, T Ichinohe, Y Atsuta, T Fukuda
In this retrospective analysis using the Transplant Registry Unified Management Program, we identified 145 patients with human herpesvirus (HHV)-6 encephalitis among 6593 recipients. The cumulative incidences of HHV-6 encephalitis at 100 days after transplantation in all patients, recipients of bone marrow or PBSCs and recipients of cord blood were 2.3%, 1.6% and 5.0%, respectively. Risk factors identified in multivariate analysis were male sex, type of transplanted cells (relative risk in cord blood transplantation, 11...
November 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28758263/anti-epileptic-drugs-induce-cutaneous-lymphocyte-associated-antigen-down-regulation-leading-to-potential-human-herpes-virus-7-reactivation-in-clinically-asymptomatic-patients
#18
F Caillot, E Andrieu, E Houivet, S Duvert-Lehembre, S Calbo, B Sabbah, D Maltete, O Martinaud, F Le Goff, P Malekpour, M Berard, S Rogez, P Joly, D Picard, P Musette
Anti-epileptic drugs (AED) are known to cause cutaneous adverse drug-induced reactions. The pathogenesis of these drug-induced reactions remains poorly understood. In our previous multicenter prospective study, we evidenced reactivation of Epstein-Barr Virus (EBV), Human Herpes Virus 6 (HHV-6) and/or Human Herpes Virus 7 (HHV-7) in 76% of Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) patients. As a consequence of this increased viral antigen exposure, EBV-specific CD8+ T lymphocytes that expressed high levels of Cutaneous Lymphocyte-associated Antigen (CLA) homing markers of skin were found both in blood and in involved organs including skin...
July 31, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28755030/the-human-vascular-endothelial-cell-line-huv-ec-c-harbors-the-integrated-hhv-6b-genome-which-remains-stable-in-long-term-culture
#19
Setsuko Shioda, Fumio Kasai, Midori Ozawa, Noriko Hirayama, Motonobu Satoh, Yousuke Kameoka, Ken Watanabe, Norio Shimizu, Huamin Tang, Yasuko Mori, Arihiro Kohara
Human herpes virus 6 (HHV-6) is a common human pathogen that is most often detected in hematopoietic cells. Although human cells harboring chromosomally integrated HHV-6 can be generated in vitro, the availability of such cell lines originating from in vivo tissues is limited. In this study, chromosomally integrated HHV-6B has been identified in a human vascular endothelial cell line, HUV-EC-C (IFO50271), derived from normal umbilical cord tissue. Sequence analysis revealed that the viral genome was similar to the HHV-6B HST strain...
July 28, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28746781/human-herpesvirus-6-encephalitis-following-chemotherapy-induction-for-acute-myelogenous-leukemia
#20
John W Frey, Joseph N Cherabie, Maha A Assi
We report a case of human herpesvirus-6 (HHV-6) encephalitis in a neutropenic patient who had undergone chemotherapy induction for acute myelogenous leukemia while on broad-spectrum antimicrobial therapy. The patient displayed symptoms of confusion, amnesia, and lethargy. Diagnosis was made via polymerase chain reaction analysis of cerebrospinal fluid. Electroencephalogram and magnetic resonance imaging of the brain were unremarkable. Following diagnosis, the patient was successfully treated with ganciclovir...
July 26, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
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