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https://www.readbyqxmd.com/read/25342196/viral-m2-ion-channel-protein-a-promising-target-for-anti-influenza-drug-discovery
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N S Hari Narayana Moorthy, Vasanthanathan Poongavanam, V Pratheepa
Influenza virus is an important RNA virus causing pandemics (Spanish Flu (1918), Asian Flu (1957), Hong Kong Flu (1968) and Swine Flu (2009)) over the last decades. Due to the spontaneous mutations of these viral proteins, currently available antiviral and anti-influenza drugs quickly develop resistance. To account this, only limited antiinfluenza drugs have been approved for the therapeutic use. These include amantadine and rimantadine (M2 proton channel blockers), zanamivir, oseltamivir and peramivir (neuraminidase inhibitors), favipravir (polymerase inhibitor) and laninamivir...
2014: Mini Reviews in Medicinal Chemistry
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