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https://www.readbyqxmd.com/read/28550793/acute-gonadotropin-releasing-hormone-agonist-treatment-enhances-extinction-memory-in-male-rats
#1
L Y Maeng, M B Taha, K K Cover, S S Glynn, M Murillo, K Lebron-Milad, M R Milad
Leuprolide acetate (LEU), also known as Lupron, is commonly used to treat prostate cancer in men. As a gonadotropin-releasing hormone (GnRH) receptor agonist, it initially stimulates the release of gonadal hormones, testosterone (T) and estradiol. This surge eventually suppresses these hormones, preventing the further growth and spread of cancer cells. Individuals receiving this treatment often report anxiety and cognitive changes, but LEU's effects on the neural mechanisms that are involved in anxiety during the trajectory of treatment are not well known...
May 17, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28550458/what-happened-in-dialogical-classes-of-intercultural-understanding-an-analysis-of-exchanging-classes-between-chinese-and-japanese-university-students
#2
Chengnan Pian
Chinese and Japanese university students make an exchanging of opinions regarding the topic "making a mobile phone call in the bus". Both sides of the communication can achieve different changes of cognition through different ways. This paper focuses on Chinese university students, and analyzes their cognition of the traffic etiquette in Japan and China. Unlike Japanese university students' change of cognition, Chinese university students have made more negative evaluation on Japanese traffic etiquette after the communication...
May 26, 2017: Integrative Psychological & Behavioral Science
https://www.readbyqxmd.com/read/28550253/is-sleep-disruption-a-risk-factor-for-alzheimer-s-disease
#3
Arthur Cassa Macedo, Sara Balouch, Naji Tabet
Sleep disturbances are routinely encountered in Alzheimer's disease (AD) and affect about 25-40% of patients in the mild-to-moderate stages of the disease. In many, sleep pathology may represent a symptom of the underlying neurodegeneration. However, a history of sleep disruption occurring years prior to onset of cognitive symptoms could represent a potential risk factor for AD. The aim of the present narrative review was to evaluate current evidence linking sleep disturbances with AD development and to understand the mechanisms that may contribute to this...
May 26, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28550099/viral-delivery-of-c9orf72-hexanucleotide-repeat-expansions-in-mice-lead-to-repeat-length-dependent-neuropathology-and-behavioral-deficits
#4
Saul Herranz-Martin, Jayanth Chandran, Katherine Lewis, Padraig Mulcahy, Adrian Higginbottom, Callum Walker, Isabel Martinez-Pena Y Valenzuela, Ross A Jones, Ian Coldicott, Tommaso Iannitti, Mohammed Akaaboune, Sherif F El-Khamisy, Thomas H Gillingwater, Pamela J Shaw, Mimoun Azzouz
Intronic GGGGCC repeat expansions in C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Two major pathologies stemming from the hexanucleotide RNA expansions (HREs) have been identified in postmortem tissue: intracellular RNA foci and repeat-associated non-ATG dependent (RAN) dipeptides, though it is unclear how these and other hallmarks of disease contribute to the pathophysiology of neuronal injury. Here we generated two novel lines of mice that overexpress either 10 pure or 102 interrupted G4C2 repeats mediated by adeno-associated virus (AAV) and characterized relevant pathology and disease-related behavioral phenotypes...
May 26, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28549887/fluvoxamine-maleate-effects-on-dopamine-signaling-in-the-prefrontal-cortex-of-stressed-parkinsonian-rats-implications-for-learning-and-memory
#5
Ernest Dallé, Willie M U Daniels, Musa V Mabandla
Parkinson's disease (PD) is also associated with cognitive impairment and reduced extrinsic supply of dopamine (DA) to the prefrontal cortex (PFC). In the present study, we looked at whether exposure to early life stress reduces DA and serotonin (5-HT) concentration in the PFC thus leading to enhanced cognitive impairment in a Parkinsonian rat model. Maternal separation was the stressor used to develop an animal model for early life stress that has chronic effects on brain and behavior. Sprague-Dawley rats were treated with the antidepressant Fluvoxamine maleate (FM) prior to a unilateral 6-hydroxydopamine (6-OHDA) lesion to model motor deficits in rats...
May 23, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28549703/integrated-care-enhancing-the-role-of-the-primary-health-care-professional-in-preventing-functional-decline-a-systematic-review
#6
REVIEW
John E Morley, Hidenori Arai, Li Cao, Birong Dong, Reshma A Merchant, Bruno Vellas, Renuka Visvanathan, Jean Woo
BACKGROUND: Although the older population is increasing worldwide, there is a marked deficit in the number of persons trained in geriatrics. It is now recognized that early detection and treatment of geriatric syndromes (frailty, sarcopenia, anorexia of aging, and cognitive decline) will delay or avert the development of disability. OBJECTIVES: To identify simple screening programs available for primary health professionals to identify geriatric syndromes. DATA SOURCES: PubMed for the last 5 years and study authors...
June 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28549609/development-and-validation-of-cf-medication-beliefs-questionnaire-a-mixed-methods-approach
#7
Michelle N Eakin, Shang-En Chung, Jessica Hoehn, Belinda Borrelli, Devin Rand-Giovannetti, Kristin A Riekert
BACKGROUND: Beliefs about medication have been associated with adherence in other diseases but there are no existing disease-specific medication beliefs questionnaires for CF. This mixed-methods validated the Cystic Fibrosis Medication Belief Questionnaire (CF-MBQ), based on social cognitive theory. METHODS: Based on previous research, items were developed for five domains: motivation, self-efficacy, perceived importance, and decisional balance to take or miss medications...
May 23, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/28549161/cigarette-smoking-cessation-intervention-for-buprenorphine-treatment-patients
#8
Sharon M Hall, Gary Humfleet, James Gasper, Kevin L Delucchi, David Hersh, Joseph Guydish
Introduction: Patients receiving Medication Assisted Therapy (MAT) for opioid use disorder have high cigarette smoking rates. Cigarette smoking interventions have had limited success. We evaluated an intervention to increase cigarette abstinence rates in patients receiving buprenorphine-assisted therapy. Methods: Cigarette smokers (N=175; 78% male; 69% Caucasian; 20% Hispanic), recruited from a buprenorphine clinic were randomly assigned to either an extended innovative system intervention (E-ISI) or to Standard Treatment Control (STC)...
May 26, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28548462/neurocognitive-mechanisms-of-real-world-autobiographical-memory-retrieval-insights-from-studies-using-wearable-camera-technology
#9
REVIEW
Tiffany E Chow, Jesse Rissman
In recent years, investigation into the cognitive and neural mechanisms of autobiographical memory has been aided by the use of experimental paradigms incorporating wearable camera technology. By effortlessly capturing first-person images of one's life events, these cameras provide a rich set of naturalistic stimuli that can later be used to trigger the recall of specific episodes. Here, we chronicle the development and progression of such studies in behavioral and neuroimaging examinations of both clinical and nonclinical adult populations...
May 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28548091/cellular-interplay-via-cytokine-hierarchy-causes-pathological-cardiac-hypertrophy-in-raf1-mutant-noonan-syndrome
#10
Jiani C Yin, Mathew J Platt, Xixi Tian, Xue Wu, Peter H Backx, Jeremy A Simpson, Toshiyuki Araki, Benjamin G Neel
Noonan syndrome (NS) is caused by mutations in RAS/ERK pathway genes, and is characterized by craniofacial, growth, cognitive and cardiac defects. NS patients with kinase-activating RAF1 alleles typically develop pathological left ventricular hypertrophy (LVH), which is reproduced in Raf1(L613V/+) knock-in mice. Here, using inducible Raf1(L613V) expression, we show that LVH results from the interplay of cardiac cell types. Cardiomyocyte Raf1(L613V) enhances Ca(2+) sensitivity and cardiac contractility without causing hypertrophy...
May 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28547824/the-promise-of-a-better-group-future-cognitive-alternatives-increase-students-self-efficacy-and-academic-performance
#11
Aarti Iyer, Airong Zhang, Jolanda Jetten, Zhen Hao, Lijuan Cui
Drawing on classic social identity theorizing (Tajfel, Differentiation between social groups: Studies in the social psychology of intergroup relations, London, UK, Academic Press, 1978), we propose that low-status minority group members' self-efficacy and performance on intellectual tasks can be enhanced by prompting them to believe in a better future for their group (i.e., increasing awareness of cognitive alternatives to the existing low-status position). Study 1 manipulated cognitive alternatives among 157 migrant workers' children in China, showing that self-efficacy was enhanced in the high compared to the low cognitive alternative condition...
May 25, 2017: British Journal of Social Psychology
https://www.readbyqxmd.com/read/28546978/effectiveness-of-concept-mapping-and-traditional-linear-nursing-care-plans-on-critical-thinking-skills-in-clinical-pediatric-nursing-course
#12
Fereshteh Aein, Fatemeh Aliakbari
INTRODUCTION: Concept map is a useful cognitive tool for enhancing a student's critical thinking (CT) by encouraging students to process information deeply for understanding. However, the evidence regarding its effectiveness on nursing students' CT is contradictory. This paper compares the effectiveness of concept mapping and traditional linear nursing care planning on students' CT. METHODS: An experimental design was used to examine the CT of 60 baccalaureate students who participated in pediatric clinical nursing course in the Shahrekord University of Medical Sciences, Shahrekord, Iran in 2013...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28545756/cognitive-behavioral-family-treatment-for-suicide-attempt-prevention-a-randomized-controlled-trial
#13
Joan Rosenbaum Asarnow, Jennifer L Hughes, Kalina N Babeva, Catherine A Sugar
OBJECTIVE: Suicide is a leading cause of death. New data indicate alarming increases in suicide death rates, yet no treatments with replicated efficacy or effectiveness exist for youths with self-harm presentations, a high-risk group for both fatal and nonfatal suicide attempts. We addressed this gap by evaluating Safe Alternatives for Teens and Youths (SAFETY), a cognitive-behavioral, dialectical behavior therapy-informed family treatment designed to promote safety. METHOD: Randomized controlled trial for adolescents (12-18 years of age) with recent (past 3 months) suicide attempts or other self-harm...
June 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28545016/statistical-learning-and-auditory-processing-in-children-with-music-training-an-erp-study
#14
Pragati Rao Mandikal Vasuki, Mridula Sharma, Ronny Ibrahim, Joanne Arciuli
OBJECTIVE: The question whether musical training is associated with enhanced auditory and cognitive abilities in children is of considerable interest. In the present study, we compared children with music training versus those without music training across a range of auditory and cognitive measures, including the ability to detect implicitly statistical regularities in input (statistical learning). METHODS: Statistical learning of regularities embedded in auditory and visual stimuli was measured in musically trained and age-matched untrained children between the ages of 9-11years...
April 26, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28544943/prevalence-of-nonsuicidal-self-injury-and-its-risk-and-protective-factors-among-adolescents-in-taiwan
#15
Min-Pei Lin, Jianing You, Yaxuan Ren, Jo Yung-Wei Wu, Wei-Hsuan Hu, Cheng-Fang Yen, Xu Zhang
The present study aimed to investigate the prevalence of nonsuicidal self-injury (NSSI) in a large representative sample of secondary school students and identified the psychosocial risk and protective factors. Using a cross-sectional design, 2170 participants were recruited from senior high schools throughout Taiwan using both stratified and cluster sampling. The one-year prevalence of NSSI was found to be 20.1%. Results suggested that compared to non-injurers, episodic self-injurers reported higher levels of neuroticism and openness, while repetitive self-injurers reported higher levels of neuroticism, openness, avoidance/emotion-focused coping, and virtual social support, and lower levels of self-esteem and cognitive reconstruction/problem-focused coping...
May 17, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28544619/design-and-synthesis-of-some-acridine-piperazine-hybrids-for-the-improvement-of-cognitive-dysfunction
#16
Anuradha Sharma, Poonam Piplani
A novel series of hybrid molecules (5a-5m) was designed, synthesized and evaluated as multifunctional cholinesterase (ChE) inhibitors against cognitive dysfunction. Heterocyclic moieties acridine and piperazine were conjugated with suitable linkers in a single scaffold and the structures of the target compounds were confirmed by IR, (1) H NMR, (13) C NMR and LC-MS analysis. The pharmacological activity of synthesized compounds was evaluated using behavioral models of amnesia viz. step down passive avoidance and elevated plus maze at a dose 0...
May 25, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28544391/the-experience-sampling-method-as-an-mhealth-tool-to-support-self-monitoring-self-insight-and-personalized-health-care-in-clinical-practice
#17
Jim van Os, Simone Verhagen, Anne Marsman, Frenk Peeters, Maarten Bak, Machteld Marcelis, Marjan Drukker, Ulrich Reininghaus, Nele Jacobs, Tineke Lataster, Claudia Simons, Richel Lousberg, Sinan Gülöksüz, Carsten Leue, Peter C Groot, Wolfgang Viechtbauer, Philippe Delespaul
BACKGROUND: The experience sampling method (ESM) builds an intensive time series of experiences and contexts in the flow of daily life, typically consisting of around 70 reports, collected at 8-10 random time points per day over a period of up to 10 days. METHODS: With the advent of widespread smartphone use, ESM can be used in routine clinical practice. Multiple examples of ESM data collections across different patient groups and settings are shown and discussed, varying from an ESM evaluation of a 6-week randomized trial of mindfulness, to a twin study on emotion dynamics in daily life...
May 23, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28543994/cognitive-enhancing-effects-of-rtms-administered-to-the-prefrontal-cortex-in-patients-with-depression-a-systematic-review-and-meta-analysis-of-individual-task-effects
#18
REVIEW
Donel M Martin, Shawn M McClintock, Jane J Forster, Tin Yan Lo, Colleen K Loo
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) is an approved therapeutic treatment of major depressive disorder and has increasing clinical use throughout the world. However, it remains unclear whether an rTMS course for depression may also produce cognitive enhancement. In a recent meta-analysis of sham-controlled randomized controlled studies (RCTs) conducted in patients with neuropsychiatric conditions, no evidence was found for generalized cognitive enhancing effects across cognitive domains with active compared to sham rTMS...
May 24, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28543670/health-and-social-care-planning-in-collaboration-in-older-persons-homes-the-perspectives-of-older-persons-family-members-and-professionals
#19
Malin Sundström, Pia Petersson, Margareta Rämgård, Linda Varland, Kerstin Blomqvist
Providing health and social care to older persons is challenging, since older persons often have multiple diseases and a complex health situation. Hence many professions and organisations are involved. Lack of interprofessional and interorganisational collaboration leads to fragmented care. Care planning meetings before hospital discharge have long been used to overcome this fragmentation, but meetings conducted at the hospital have limitations in identifying long-term needs at home. A new model for health and social care planning in collaboration (HSCPC) in older persons' homes was introduced in two Swedish municipalities...
May 24, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28542927/research-review-what-do-we-know-about-psychopathic-traits-in-children
#20
Randall T Salekin
BACKGROUND: Research on the topic of child psychopathy has advanced over the past decade increasing what we know. METHOD: This qualitative review examines the research base for child psychopathy and emphasizes its three dimensions: grandiose-manipulative, callous-unemotional, and daring-impulsive. Literature is reviewed addressing the cognitive, emotional, motivational, personality, parenting, and biological correlates. RESULTS: Support has emerged for the phenotypic construct of child psychopathy, while questions remain regarding definitional issues and key external correlates (e...
May 24, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
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