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https://www.readbyqxmd.com/read/29161629/the-effects-of-felbamate-on-appetitive-and-aversive-instrumental-learning-in-adult-rats
#1
John J Orczyk, Preston E Garraghty
Antiepileptic medications are the frontline treatment for seizure conditions but are not without cognitive side effects. Previously, our laboratory reported learning deficits in phenytoin-, carbamazepine-, and valproate-treated rats. In the present experiment, the effects of felbamate (FBM) have been compared to water-treated controls (controls) using the same instrumental training tasks employed here. Rats treated with FBM displayed a deficit in acquiring a tone-signaled avoidance response, relative to controls, but this was true only if they had no prior appetitive experience...
November 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29161383/basal-forebrain-gating-by-somatostatin-neurons-drives-prefrontal-cortical-activity
#2
Nelson Espinosa, Alejandra Alonso, Cristian Morales, Pedro Espinosa, Andrés E Chávez, Pablo Fuentealba
The basal forebrain provides modulatory input to the cortex regulating brain states and cognitive processing. Somatostatin-expressing neurons constitute a heterogeneous GABAergic population known to functionally inhibit basal forebrain cortically projecting cells thus favoring sleep and cortical synchronization. However, it remains unclear if somatostatin cells can regulate population activity patterns in the basal forebrain and modulate cortical dynamics. Here, we demonstrate that somatostatin neurons regulate the corticopetal synaptic output of the basal forebrain impinging on cortical activity and behavior...
November 17, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29161358/neural-mechanisms-of-episodic-retrieval-support-divergent-creative-thinking
#3
Kevin P Madore, Preston P Thakral, Roger E Beaty, Donna Rose Addis, Daniel L Schacter
Prior research has indicated that brain regions and networks that support semantic memory, top-down and bottom-up attention, and cognitive control are all involved in divergent creative thinking. Kernels of evidence suggest that neural processes supporting episodic memory-the retrieval of particular elements of prior experiences-may also be involved in divergent thinking, but such processes have typically been characterized as not very relevant for, or even a hindrance to, creative output. In the present study, we combine functional magnetic resonance imaging with an experimental manipulation to test formally, for the first time, episodic memory's involvement in divergent thinking...
November 17, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29161007/polymer-based-technologies-for-sensing-applications
#4
Wildemar Stefanio Pereira Carvalho, Menglian Wei, Nduka Ikpo, Yongfeng Gao, Michael J Serpe
Reports in the literature on the development of new chemical sensing technologies have been growing steadily in number for years. For example, a Web of Science topic search using the term "Chemical Sensing" revealed that over 8,000 papers were published in 2015-2017, with over 40,000 citations to those papers. In this review, we focus on highlighting recent examples of chemical sensing related to human health (e.g., disease diagnosis, health monitoring, and water/food safety), and for environmental monitoring...
November 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29159197/donepezil-enhances-understanding-of-degraded-speech-in-alzheimer-s-disease
#5
Chris J D Hardy, Yun T Hwang, Rebecca L Bond, Charles R Marshall, Basil H Ridha, Sebastian J Crutch, Martin N Rossor, Jason D Warren
Auditory dysfunction under complex, dynamic listening conditions is a clinical hallmark of Alzheimer's disease (AD) but challenging to measure and manage. Here, we assessed understanding of sinewave speech (a paradigm of degraded speech perception) and general cognitive abilities in 17 AD patients, before and following a 10 mg dose of donepezil. Relative to healthy older individuals, patients had impaired sinewave speech comprehension that was selectively ameliorated by donepezil. Our findings demonstrate impaired perception of degraded speech in AD but retained perceptual learning capacity that can be harnessed by acetylcholinesterase inhibition, with implications for designing communication interventions and acoustic environments in dementia...
November 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29159056/no-association-of-cortical-amyloid-load-and-eeg-connectivity-in-older-people-with-subjective-memory-complaints
#6
Stefan Teipel, Hovagim Bakardjian, Gabriel Gonzalez-Escamilla, Enrica Cavedo, Sarah Weschke, Martin Dyrba, Michel J Grothe, Marie-Claude Potier, Marie-Odile Habert, Bruno Dubois, Harald Hampel
Changes in functional connectivity of cortical networks have been observed in resting-state EEG studies in healthy aging as well as preclinical and clinical stages of AD. Little information, however, exists on associations between EEG connectivity and cortical amyloid load in people with subjective memory complaints. Here, we determined the association of global cortical amyloid load, as measured by florbetapir-PET, with functional connectivity based on the phase-lag index of resting state EEG data for alpha and beta frequency bands in 318 cognitively normal individuals aged 70-85 years with subjective memory complaints from the INSIGHT-preAD cohort...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29159020/the-current-agonists-and-positive-allosteric-modulators-of-%C3%AE-7-nachr-for-cns-indications-in-clinical-trials
#7
REVIEW
Taoyi Yang, Ting Xiao, Qi Sun, Kewei Wang
The alpha-7 nicotinic acetylcholine receptor (α7 nAChR), consisting of homomeric α7 subunits, is a ligand-gated Ca(2+)-permeable ion channel implicated in cognition and neuropsychiatric disorders. Enhancement of α7 nAChR function is considered to be a potential therapeutic strategy aiming at ameliorating cognitive deficits of neuropsychiatric disorders such as Alzheimer's disease (AD) and schizophrenia. Currently, a number of α7 nAChR modulators have been reported and several of them have advanced into clinical trials...
November 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/29158964/ginsenoside-rk1-bioactivity-a-systematic-review
#8
Abdelrahman Elshafay, Ngo Xuan Tinh, Samar Salman, Yara Saber Shaheen, Eman Bashir Othman, Mohamed Tamer Elhady, Aswin Ratna Kansakar, Linh Tran, Le Van, Kenji Hirayama, Nguyen Tien Huy
Ginsenoside Rk1 (G-Rk1) is a unique component created by processing the ginseng plant (mainly Sung Ginseng (SG)) at high temperatures. The aim of our study was to systematically review the pharmacological effects of G-Rk1. We utilized and manually searched eight databases to select in vivo and in vitro original studies that provided information about biological, pharmaceutical effects of G-Rk1 and were published up to July 2017 with no restriction on language or study design. Out of the 156 papers identified, we retrieved 28 eligible papers in the first skimming phase of research...
2017: PeerJ
https://www.readbyqxmd.com/read/29158872/neuroprotective-and-cognitive-enhancing-effects-of-microencapsulation-of-mulberry-fruit-extract-in-animal-model-of-menopausal-women-with-metabolic-syndrome
#9
Supannika Kawvised, Jintanaporn Wattanathorn, Wipawee Thukham-Mee
Currently, the neuroprotectant and memory-enhancing agent for menopausal women with metabolic syndrome is required. Based on the advantages of polyphenolics on numerous changes observed in menopause with metabolic syndrome and the encapsulation method, we hypothesized that microencapsulated mulberry fruit extract (MME) could protect brain damage and improve memory impairment in an animal model of menopause with metabolic syndrome. To test this hypothesis, MME at doses of 10, 50, and 250 mg/kg was given to female Wistar rats which were induced experimental menopause with metabolic syndrome by bilateral ovariectomy (OVX) and fed with high-carbohydrate high-fat (HCHF) diet for 8 weeks...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29158668/reversal-of-cognitive-impairment-in-a-hypotensive-elderly-population-using-a-passive-exercise-intervention
#10
Kenneth J McLeod, Astrid Stromhaug
Background: Cognitive decline in the elderly is strongly associated with cerebral hypoperfusion, a condition that can be reversed with exercise. Adhering to a traditional exercise regimen, however, is challenging for this population. Objective: In a pilot clinical study, we evaluated the ability of a "passive" exercise regimen (noninvasive calf muscle pump stimulation) to normalize blood pressure in a chronically hypotensive elderly population and enhance cognitive function...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29158667/different-protocols-for-analyzing-behavior-and-adaptability-in-obstacle-crossing-in-parkinson-s-disease
#11
REVIEW
Nafiseh Mollaei, Estela Bicho, Nuno Sousa, Miguel Fernandes Gago
Imbalance and tripping over obstacles as a result of altered gait in older adults, especially in patients with Parkinson's disease (PD), are one of the most common causes of falls. During obstacle crossing, patients with PD modify their behavior in order to decrease the mechanical demands and enhance dynamic stability. Various descriptions of dynamic traits of gait that have been collected over longer periods, probably better synthesize the underlying structure and pattern of fluctuations in gait and can be more sensitive markers of aging or early neurological dysfunction and increased risk of falls...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29158372/enhancing-next-generation-sequencing-guided-cancer-care-through-cognitive-computing
#12
Nirali M Patel, Vanessa V Michelini, Jeff M Snell, Saianand Balu, Alan P Hoyle, Joel S Parker, Michele C Hayward, David A Eberhard, Ashley H Salazar, Patrick McNeillie, Jia Xu, Claudia S Huettner, Takahiko Koyama, Filippo Utro, Kahn Rhrissorrakrai, Raquel Norel, Erhan Bilal, Ajay Royyuru, Laxmi Parida, H Shelton Earp, Juneko E Grilley-Olson, D Neil Hayes, Stephen J Harvey, Norman E Sharpless, William Y Kim
BACKGROUND: Using next-generation sequencing (NGS) to guide cancer therapy has created challenges in analyzing and reporting large volumes of genomic data to patients and caregivers. Specifically, providing current, accurate information on newly approved therapies and open clinical trials requires considerable manual curation performed mainly by human "molecular tumor boards" (MTBs). The purpose of this study was to determine the utility of cognitive computing as performed by Watson for Genomics (WfG) compared with a human MTB...
November 20, 2017: Oncologist
https://www.readbyqxmd.com/read/29158117/cold-acclimation-and-cognitive-performance-a-review
#13
Douglas M Jones, Stephen P Bailey, Bart Roelands, Michael J Buono, Romain Meeusen
Athletes, occupational workers, and military personnel experience cold temperatures through cold air exposure or cold water immersion, both of which impair cognitive performance. Prior work has shown that neurophysiological pathways may be sensitive to the effects of temperature acclimation and, therefore, cold acclimation may be a potential strategy to attenuate cold-induced cognitive impairments for populations that are frequently exposed to cold environments. This review provides an overview of studies that examine repeated cold stress, cold acclimation, and measurements of cognitive performance to determine whether or not cold acclimation provides beneficial protection against cold-induced cognitive performance decrements...
November 17, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29156991/repeated-mild-traumatic-brain-injury-produces-neuroinflammation-anxiety-like-behaviour-and-impaired-spatial-memory-in-mice
#14
John I Broussard, Laura Acion, Héctor De Jesús-Cortés, Terry Yin, Jeremiah K Britt, Ramiro Salas, Mauro Costa-Mattioli, Claudia Robertson, Andrew A Pieper, David B Arciniegas, Ricardo Jorge
PRIMARY OBJECTIVE: Repeated traumatic brain injuries (rmTBI) are frequently associated with debilitating neuropsychiatric conditions such as cognitive impairment, mood disorders, and post-traumatic stress disorder. We tested the hypothesis that repeated mild traumatic brain injury impairs spatial memory and enhances anxiety-like behaviour. RESEARCH DESIGN: We used a between groups design using single (smTBI) or repeated (rmTBI) controlled cranial closed skull impacts to mice, compared to a control group...
November 20, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29156905/i-hurt-so-hypnotic-interventions-and-palliative-care-for-traumatic-brain-injury
#15
Donald Moss
This article presents a case study in which self-hypnosis, hypnosis-assisted psychotherapy, and palliative care strategies were provided within a multi-modal integrative treatment program for a 38-year-old woman with traumatic brain injury (TBI) secondary to motor vehicle accident. Self-hypnosis was helpful in anxiety reduction and pain management. Hypnosis-assisted psychotherapy was beneficial in de-sensitizing many post-traumatic memories, and in managing post-concussion pain, including neuropathic pain and post-traumatic migraine headaches...
September 12, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29155302/repeated-exposure-to-sevoflurane-impairs-the-learning-and-memory-of-older-male-rats
#16
Shanbin Guo, Lidan Liu, Cong Wang, Qian Jiang, Yunxia Dong, Yue Tian
AIMS: Critically ill old patients sometimes require repeated surgical interventions, and thus it is important to determine the influence of repeated exposure to anesthetics on learning and memory. Sevoflurane, a widely used inhalation anesthetic, has few neurological adverse effects and offers a rapid return to consciousness. But the long-term influence of sevoflurane exposure and the effect of repeated sevoflurane exposure on cognition have rarely been reported, and available studies are contradictory...
November 16, 2017: Life Sciences
https://www.readbyqxmd.com/read/29154798/non-pharmacological-interventions-for-reducing-mental-distress-in-patients-undergoing-dental-procedures-systematic-review-and-meta-analysis
#17
REVIEW
Sophia Burghardt, Susan Koranyi, Gabriel Magnucki, Bernhard Strauss, Jenny Rosendahl
OBJECTIVES: This meta-analysis investigates the efficacy of non-pharmacological interventions in adults undergoing dental procedures under regional or general anesthesia compared to standard care alone or an attention control group on the reduction of mental distress, pain, and analgesic use. DATA SOURCES: To identify relevant papers a comprehensive literature search was carried out in MEDLINE, CENTRAL, Web of Science, and PsycINFO (last search August, 2017). Additionally, lists of references of relevant articles and previous reviews were checked...
November 14, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29154554/associations-between-executive-functioning-affect-regulation-drinking-motives-and-alcohol-use-and-problems
#18
Jorge S Martins, Bruce D Bartholow, M Lynne Cooper, Curtis D Von Gunten, Phillip K Wood
Motivation to use alcohol to regulate positive and negative affect and deficits in cognitive control (i.e., executive functions [EFs]) have both been associated with increased alcohol involvement and alcohol-related consequences. Although dual-process models predict that affect-driven motivations and cognitive control should interact to determine alcohol involvement and alcohol-related consequences, this intersection has remained largely unexplored. The present study examined the extent to which effects of enhancement and coping drinking motives on alcohol use, heavy drinking, and alcohol-related consequences are moderated by individual differences in three theorized components of EF...
November 20, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/29154553/a-randomized-trial-of-female-specific-cognitive-behavior-therapy-for-alcohol-dependent-women
#19
Elizabeth E Epstein, Barbara S McCrady, Kevin A Hallgren, Sharon Cook, Noelle K Jensen, Thomas Hildebrandt
This study compared Female-Specific Cognitive Behavioral Therapy (FS-CBT) to evidence-based, gender-neutral CBT (GN-CBT; Epstein & McCrady, 2009) for women with alcohol use disorder (AUD). Women (N = 99) with AUD, mean age 48, were randomly assigned to 12 outpatient manual-guided sessions of FS-CBT (n = 44) or GN-CBT (n = 55). Women were assessed at baseline and 3, 9 and 15 months after baseline for drinking and for specific issues common among women with AUD. A FS-CBT protocol was developed that was discriminable on treatment integrity ratings from GN-CBT...
November 20, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/29154509/technology-assisted-rehabilitation-interventions-following-pediatric-brain-injury
#20
Shari L Wade, Megan E Narad, Emily L Shultz, Brad G Kurowski, Aimee E Miley, Jessica M Aguilar, Anna-Lynne R Adlam
INTRODUCTION: Following traumatic brain injury (TBI), children experience a variety of physical, motor, speech, and cognitive deficits that can have a long-term detrimental impact. The emergence and popularity of new technologies has led to research into the development of various apps, gaming systems, websites, and robotics that might be applied to rehabilitation. The objective of this narrative review was to describe the current literature technologically-assisted interventions for the rehabilitation of motor, neurocognitive, behavioral, and family impairments following pediatric TBI...
November 20, 2017: Journal of Neurosurgical Sciences
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