Jorge Felipe Argenta Model, Matheus Vieira Lima, Renata Ohlweiler, Éverton Vogt, Débora Santos Rocha, Samir Khal de Souza, Patrick Turck, Alex Sander da Rosa Araújo, Anapaula Sommer Vinagre
Considering that post-menopausal women and ovariectomized rodents develop obesity associated with increased visceral fat, this study was developed to investigate if liraglutide, a glucagon-like peptide 1 (GLP1) analogue, could improve the metabolism of estrogen (E2) deficient females. Wistar rats were ovariectomized (OVX), and subdivided in four groups: sham saline, sham liraglutide, OVX saline, and OVX liraglutide. After sixty days, metabolic parameters of blood, heart, liver, brown (BAT) and white adipose tissue (WAT) visceral depots, and, heart oxidative homeostasis, were evaluated...
January 11, 2021: Molecular and Cellular Endocrinology