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https://www.readbyqxmd.com/read/29913946/co-administered-gabapentin-and-venlafaxine-in-nerve-injured-rats-effect-on-mechanical-hypersensitivity-motor-function-and-pharmacokinetics
#1
Anna Folkesson, Per Hartvig Honoré, Ole J Bjerrum
A high proportion of patients suffering from neuropathic pain do not receive satisfactory pain relief from their current treatment, due to incomplete efficacy and dose-limiting adverse effects. Hence, one strategy to improve treatment outcome is the use of a combination of analgesic drugs. The potential benefits of such approach include improved and prolonged duration of analgesic effect and fewer or milder adverse effects with lower doses of each drug. Gabapentin is recommended as a first-line drug in the treatment of neuropathic pain, and has recently been demonstrated to act on supraspinal structures to stimulate the descending noradrenergic pain inhibitory system...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29909652/improvement-in-overactive-bladder-symptoms-in-patients-using-functional-electrical-stimulation-of-the-common-peroneal-nerve-for-walking
#2
Nicola Hare, Petros Georgopoulos, Kate E Philips, Joanne E Johnson, Coralie Seary, Jalesh N Panicker, Valerie L Stevenson
OBJECTIVE: Functional electrical stimulation is used to improve walking speed and reduces falls in people with upper motor neurone foot-drop. Following anecdotal observations of changes in bladder symptoms, an observational study was performed to explore this association further. DESIGN: A total of 47 consecutive patients attending for setup with functional electrical stimulation during a six-month period were asked to complete a questionnaire assessing bladder symptoms (ICIQ-OAB (International Consultation on Incontinence Questionnaire Overactive Bladder)) at baseline and three  months during routine appointments...
June 1, 2018: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29898474/incidence-of-concurrent-peroneal-nerve-injury-in-multiligament-knee-injuries-and-outcomes-after-knee-reconstruction
#3
John R Worley, Olubusola Brimmo, Clayton W Nuelle, James L Cook, James P Stannard
The purpose of this study was to determine incidence of concurrent peroneal nerve injury and to compare outcomes in patients with and without peroneal nerve injury after surgical treatment for multiligament knee injuries (MLKIs). A retrospective study of 357 MLKIs was conducted. Patients with two or more knee ligaments requiring surgical reconstruction were included. Mean follow-up was 35 months (0-117). Incidence of concurrent peroneal nerve injury was noted and patients with and without nerve injury were evaluated for outcomes...
June 13, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29889258/trends-and-cost-analysis-of-lower-extremity-nerve-injury-using-the-national-inpatient-sample
#4
Chase H Foster, Michael Karsy, Michael R Jensen, Jian Guan, Ilyas Eli, Mark A Mahan
BACKGROUND: Peripheral nerve injuries (PNIs) of the lower extremities have been assessed in small cohort studies; however, the actual incidence, national trends, comorbidities, and cost of care in lower extremity PNI are not defined. Lack of sufficient data limits discussion on national policies, payors, and other aspects fundamental to the delivery of care in the US. OBJECTIVE: To establish estimates of lower extremity PNIs incidence, associated diagnoses, and cost in the US using a comprehensive database with a minimum of a decade of data...
June 8, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29889089/kinematic-and-kinetic-benefits-of-implantable-peroneal-nerve-stimulation-in-people-with-post-stroke-drop-foot-using-an-ankle-foot-orthosis
#5
Frank Berenpas, Sven Schiemanck, Anita Beelen, Frans Nollet, Vivian Weerdesteyn, Alexander Geurts
BACKGROUND: Contralesional 'drop foot' after stroke is usually treated with an ankle-foot orthosis (AFO). However, AFOs may hamper ankle motion during stance. Peroneal functional electrical stimulation (FES) is an alternative treatment that provides active dorsiflexion and allows normal ankle motion. Despite this theoretical advantage of FES, the kinematic and kinetic differences between AFO and FES have been scarcely investigated. OBJECTIVE: To test whether walking with implanted FES leads to improvements in stance stability, propulsion, and swing initiation compared to AFO...
June 6, 2018: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29845044/immediate-nerve-transfer-for-treatment-of-peroneal-nerve-palsy-secondary-to-an-intraneural-ganglion-case-report-and-review
#6
Imran Ratanshi, Tod A Clark, Jennifer L Giuffre
Intraneural ganglion cysts, which occur within the common peroneal nerve, are a rare cause of foot drop. The current standard of treatment for intraneural ganglion cysts involving the common peroneal nerve involves (1) cyst decompression and (2) ligation of the articular nerve branch to prevent recurrence. Nerve transfers are a time-dependent strategy for recovering ankle dorsiflexion in cases of high peroneal nerve palsy; however, this modality has not been performed for intraneural ganglion cysts involving the common peroneal nerve...
May 2018: Plastic Surgery
https://www.readbyqxmd.com/read/29802558/causes-of-peroneal-neuropathy-associated-with-orthopaedic-leg-lengthening-in-different-canine-models
#7
Natalia A Shchudlo, Tatyana N Varsegova, Mikhail M Shchudlo, Mikhail A Stepanov, Andrey A Yemanov
Peroneal neuropathy is one of the complications of orthopaedic leg lengthening. Methods of treatment include slowing of distraction and decompression both of which may lead to additional complications. The purpose of this study was to analyse the changes in histologic peroneal nerve structure during experimental orthopaedic lengthening using various modes of manual or automatic distraction. The obtained data provide the basis for better understanding of peroneal neuropathy pathogenesis and refinement of prophylaxis and preventive treatment protocols...
May 25, 2018: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/29767272/the-esska-afas-international-consensus-statement-on-peroneal-tendon-pathologies
#8
REVIEW
Pim A van Dijk, David Miller, James Calder, Christopher W DiGiovanni, John G Kennedy, Gino M Kerkhoffs, Akos Kynsburtg, Daniel Havercamp, Stephane Guillo, Xavier M Oliva, Chris J Pearce, Helder Pereira, Pietro Spennacchio, Joanna M Stephen, C Niek van Dijk
INTRODUCTION: Peroneal tendon injuries are a significant cause of lateral ankle symptoms in the active population. Accurate diagnosis and prompt treatment is important for minimizing the risk of long-term sequelae associated with chronic peroneal tendinopathy. Although several studies have been published on diagnostic strategies and treatment outcomes, there is no consensus on the optimal management of peroneal tendon pathologies. PURPOSE: The purpose of this ESSKA-AFAS consensus statement was to conduct an international and multidisciplinary agreed guideline on management of patients with peroneal tendon pathologies...
May 16, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29765578/lipid-lowering-drugs-statins-and-peripheral-neuropathy
#9
Mohammadreza Emad, Hosein Arjmand, Hamid Reza Farpour, Bahareh Kardeh
Background and aim: Peripheral neuropathy is a disorder with often unknown causes. Some drugs, including statins, are proposed to be among the causes of peripheral neuropathy. This study aimed at evaluating this condition by electrodiagnostic study among patients who had received statins. Methods: This case-control study was conducted in Shiraz, Iran in 2015, and included 39 patients aged 35-55 who had received statins for at least 6 months, and 39 healthy matched controls...
March 2018: Electronic Physician
https://www.readbyqxmd.com/read/29764455/nerve-trauma-of-the-lower-extremity-evaluation-of-60-422-leg-injured-patients-from-the-traumaregister-dgu%C3%A2-between-2002-and-2015
#10
Torge Huckhagel, Jakob Nüchtern, Jan Regelsberger, Mathias Gelderblom, Rolf Lefering
BACKGROUND: Nerve lesions are well known reasons for reduced functional capacity and diminished quality of life. By now only a few epidemiological studies focus on lower extremity trauma related nerve injuries. This study reveals frequency and characteristics of nerve damages in patients with leg trauma in the European context. METHODS: Sixty thousand four hundred twenty-two significant limb trauma cases were derived from the TraumaRegister DGU® between 2002 and 2015...
May 15, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29746804/contemporary-approaches-to-in-transit-melanoma
#11
Jennifer A Perone, Nellie Farrow, Douglas S Tyler, Georgia M Beasley
In-transit melanoma represents a distinct disease pattern of heterogeneous superficial tumors. Many treatments have been developed specifically for this type of disease, including regional chemotherapy and a variety of directly injectable agents. Novel strategies include the intralesional delivery of oncolytic viruses and immunocytokines. The combination of intralesional or regional chemotherapy with systemic immune checkpoint inhibitors also is a promising approach. In the current review, we examine the general management of the workup of patients with in-transit disease, the range of available therapies, and recommendations for specific therapies for an individual patient...
May 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29744050/iatrogenic-nerve-lesion-following-laparoscopic-surgery-a-case-report
#12
Michele Vecchio, Andrea Santamato, Fortunato Geneovese, Giulia Malaguarnera, Vito Emanuele Catania, Saverio Latteri
Background: Peripheral neuropathy after surgical treatment is an under recognized potential untoward event. Pelvic surgery may be associated with nerve lesions by essentially three main mechanisms: transection, entrapment and pressure-stretching; the latter is the modality most frequently linked to patient's positioning on the operating room table. Presentation of the case: A 25 years old woman, after undergoing a laparoscopic gynaecologic procedure lasted >3 hours, on postoperative day one presented with numbness over her lateral right leg and dorsum of the foot, right foot drop and gait instability due to compression-stretching of the right superficial peroneal nerve...
April 2018: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29730061/computed-tomographic-angiographic-perforator-localization-for-virtual-surgical-planning-of-osteocutaneous-fibular-free-flaps-in-head-and-neck-reconstruction
#13
Kyle S Ettinger, Amy E Alexander, Kevin Arce
Virtual surgical planning (VSP), computer-aided design and computer-aided modeling, and 3-dimensional printing are 3 distinct technologies that have become increasingly used in head and neck oncology and microvascular reconstruction. Although each of these technologies has long been used for treatment planning in other surgical disciplines, such as craniofacial surgery, trauma surgery, temporomandibular joint surgery, and orthognathic surgery, its widespread use in head and neck reconstructive surgery remains a much more recent event...
April 10, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29729258/compliance-with-hepatocellular-carcinoma-surveillance-guidelines-associated-with-increased-lead-time-adjusted-survival-of-patients-with-compensated-viral-cirrhosis
#14
Charlotte Costentin, Richard Layese, Valérie Bourcier, Carole Cagnot, Patrick Marcellin, Dominique Guyader, Stanislas Pol, Dominique Larrey, Victor De Lédinghen, Denis Ouzan, Fabien Zoulim, Dominique Roulot, Albert Tran, Jean-Pierre Bronowicki, Jean-Pierre Zarski, Ghassan Riachi, Paul Calès, Jean-Marie Péron, Laurent Alric, Marc Bourlière, Philippe Mathurin, Jean-Frédéric Blanc, Armand Abergel, Lawrence Serfaty, Ariane Mallat, Jean-Didier Grangé, Pierre Attali, Yannick Bacq, Claire Wartelle, Thông Dao, Dominique Thabut, Christophe Pilette, Christine Silvain, Christos Christidis, Eric Nguyen-Khac, Brigitte Bernard-Chabert, David Zucman, Vincent Di Martino, Angela Sutton, Eric Letouzé, Sandrine Imbeaud, Jessica Zucman-Rossi, Etienne Audureau, Françoise Roudot-Thoraval, Pierre Nahon
BACKGROUND AND AIMS: Semi-annual surveillance for hepatocellular carcinoma (HCC) is recommended for patients with cirrhosis. We aimed to determine how compliance with HCC surveillance guidelines affects survival times of patients with hepatitis C virus (HCV)- or HBV-associated compensated cirrhosis who developed HCC. METHODS: We collected data from the prospective ANRS CO12 CirVir study, from March 2006 through June 2012, on 1671 patients with biopsy-proven viral cirrhosis and no previous liver complications who were undergoing surveillance for HCC at 35 centers in France...
May 2, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29718808/differences-in-lumbar-motor-neuron-pruning-in-an-animal-model-of-early-onset-spasticity
#15
Joline E Brandenburg, Heather M Gransee, Matthew J Fogarty, Gary C Sieck
Motor neuron (MN) development in early onset spasticity is poorly understood. For example, spastic cerebral palsy (sCP), the most common motor disability of childhood, is poorly predicted by brain imaging, yet research remains focused on the brain. By contrast, MNs, via the motor unit and neurotransmitter signaling, are the target of most therapeutic spasticity treatments and are the final common output of motor control. MN development in sCP is a critical knowledge gap as the late embryonic and postnatal periods are not only when the supposed brain injury occurs, but are critical times for spinal cord neuromotor development...
May 2, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29685562/superficial-peroneal-nerve-to-deep-peroneal-nerve-transfer-with-allograft-conduit-for-neuroma-in-continuity
#16
Christopher Bibbo, Edgardo Rodrigues-Colazzo, Adam G Finzen
The anterior approach to the ankle for surgery can result in injury to the superficial peroneal nerve, resulting in a painful neuroma and significant patient morbidity. A paucity of data is available evaluating the role of the superficial peroneal nerve to deep peroneal nerve transfer as a method of treatment of neuromas in continuity after ankle arthrodesis. We describe 11 patients who underwent nerve transfer with nerve allograft and conduit repair to treat recalcitrant painful neuromas after ankle arthrodesis...
May 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29685560/high-rates-of-psychiatric-disorders-and-below-normal-mental-capacity-associated-with-spastic-peroneal-flatfoot-a-new-relationship
#17
Önder İsmet Kılıçoğlu, Ahmet Salduz, Fevzi Birişik, Fuat Bilgili, Gökhan Polat, İlyas Kaya, Funda Süleyman, Murat Coşkun
Spastic peroneal flatfoot (SPFF) is a rare hindfoot pathology usually seen in the adolescent age group that is characterized by painful spasms in the peroneal muscles. We have clinically observed that patients with SPFF also have some behavioral and emotional difficulties and problems in their academic achievements. Because of these observations, we investigated the prevalence and patterns of psychiatric disorders and intellectual disability among young subjects with SPFF. Our cohort consisted of 16 patients with SPFF...
May 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29685023/extracorporeal-shockwave-therapy-versus-exercise-program-in-patients-with-low-back-pain-short-term-results-of-a-randomised-controlled-trial
#18
A Notarnicola, G Maccagnano, M F Gallone, L Mastromauro, F Rifino, V Pesce, I Covelli, B Moretti
The physiotherapy treatment of low back pain (LBP) with physical stimulation offers different possibilities of application. Until now, the physical therapies used in LBP are laser therapy, ultrasonotherapy and currents. We conducted a clinical trial in order to verify whether shockwave therapy, which is very effective in treating tendinopathies and fracture consolidation delays, leads to clinical and electromyographic improvement in patients affected by LBP. We randomized thirty patients affected by LBP treated with shock waves (shockwave group) or a standard protocol characterized by rehabilitative exercises (control group)...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29625184/clinical-results-of-peroneal-tendon-repair-in-a-retrospective-series-of-30-patients
#19
C Bourgault, C Pougès, C Szymanski, C Lalanne, A Thioun, K Soudy, C Maynou
INTRODUCTION: Peroneal tendinopathy is an under-diagnosed pathology, mainly triggered by ankle sprain. Failure of medical treatment often leads to surgery, with modalities adapted to the lesion type. The present study aimed to assess clinical and functional results of tendon repair and to analyze the influence of hindfoot alignment on quality of outcome. The study hypothesis was that hindfoot varus impairs medium-term results. MATERIALS AND METHODS: A retrospective series of 30 patients undergoing peroneal tendon repair or tenodesis was analyzed at a mean 20 months' follow-up...
April 3, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29619066/efficacy-and-safety-of-the-injection-of-the-traditional-chinese-medicine-puerarin-for-the-treatment-of-diabetic-peripheral-neuropathy-a-systematic-review-and-meta-analysis-of-53-randomized-controlled-trials
#20
REVIEW
Baocheng Xie, Qinghui Wang, Chenhui Zhou, Jiahuan Wu, Daohua Xu
Objective: The injection of the traditional Chinese patent medicine puerarin has been widely used in the treatment of various diseases such as angina pectoris or ischemic stroke. We aim to evaluate the efficacy and safety of puerarin injection for the treatment of diabetic peripheral neuropathy (DPN). Methods: A systematic literature search was performed in seven medical databases from their inception until June 2017. 53 studies with RCTs, totaling 3284 patients, were included in this meta-analysis...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
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