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Tara L White, Mollie A Monnig, Edward G Walsh, Adam Z Nitenson, Ashley D Harris, Ronald A Cohen, Eric C Porges, Adam J Woods, Damon G Lamb, Chelsea A Boyd, Sinda Fekir
Prescription psychostimulants produce rapid changes in mood, energy, and attention. These drugs are widely used and abused. However, their effects in human neocortex on glutamate and glutamine (pooled as Glx), and key neurometabolites such as N-acetylaspartate (tNAA), creatine (tCr), choline (Cho), and myo-inositol (Ins) are poorly understood. Changes in these compounds could inform the mechanism of action of psychostimulant drugs and their abuse potential in humans. We investigated the acute impact of two FDA-approved psychostimulant drugs on neurometabolites using magnetic resonance spectroscopy (1 H MRS)...
June 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Li-Tzy Wu, Marvin S Swartz, Kathleen T Brady, Dan G Blazer, Rick H Hoyle
There are concerns over nonmedical use of prescription stimulants among youths, but little is known about the extent of use among young Asian-Americans, Native Hawaiians/Pacific Islanders (NHs/PIs), and mixed-race individuals-the fastest growing segments of the U.S. population. We examined prevalences and correlates of nonmedical stimulant use (NMSU) and disorder (StiUD) for these underrecognized groups. Whites were included as a comparison. Data were from young individuals aged 12-34 years in the 2005-2012 National Surveys on Drug Use and Health...
December 2014: Journal of Psychiatric Research
No abstract text is available yet for this article.
April 1955: Neurology
No abstract text is available yet for this article.
March 1958: Psychosomatic Medicine
No abstract text is available yet for this article.
December 1957: Diseases of the Nervous System
No abstract text is available yet for this article.
January 1956: A.M.A. Archives of Neurology and Psychiatry
K S Chertkov, I E Andrianova, V N Andrushchenko, L A Vernigorova, V A Glushkov, S A Davydova, E A Revskaia
We present the results of a long-standing experimental development of ways and means for acute radiation sickness treatment that have been authorized for application in medicine and are mostly aimed at large-scale accidental injuries. The paper describes means for early treatment (prodigiosan, desoxynate, typhoid vaccine, proteus vaccine), a myeolopoiesis stimulant (estradiol dipropionate), a detoxication procedure (hemosorption), substitution therapy with bone marrow cells and peripheral blood mononuclears, anti-infectious schemes comprising antibiotics and polyvitamins...
September 1999: Radiatsionnaia Biologiia, Radioecologiia
M Perez-Reyes, W R White, S A McDonald, R E Hicks, A R Jeffcoat, J M Hill, C E Cook
This study investigated alterations in the disposition and pharmacodynamics of methamphetamine HCl after daily administration. Six male paid volunteers familiar with the use of amphetamines participated. Each subject was administered 10 mg of methamphetamine HCl as a slow-release preparation (Desoxyn Gradumets) at 9 a.m. for 13 consecutive days (days 2-14 of the study). On days 1 and 15 the subjects were challenged with 10 mg of oral deuterated methamphetamine HCl. Deuterated drug was used to differentiate plasma concentrations of challenge doses from those of daily doses...
August 1991: Clinical Neuropharmacology
G T Shybut, W R Richter, C R Schuster
Eleven Rhesus monkeys received injections of intravenous methamphetamine hydrochloride (Desoxyn) and/or intra-arterial 60% iothalamate meglumine (Conray) according to a schedule previously reported to produce marked radiological and pathological changes in the cerebral vasculature of the Rhesus monkey. While radiological changes consistent with impaired cerebral circulation were observed, they could not be correlated directly with the administration of intravenous methamphetamine because of the trauma and variability of the technique utilized...
September 1976: Research Communications in Chemical Pathology and Pharmacology
C L Rumbaugh, H C Fang, R E Higgins, R T Bergeron, H D Segall, J S Teal
An experimental drug abuse research project is reported, in which monkeys and rats were placed on various I.V. amphetamine (Desoxyn) and I.V. barbiturate (Seconal) regimes. The monkeys were studied by serial cerebral angiography. At the end of the study all animals were sacrificed for histological examination. I.V. methamphetamine produced relatively severe cerebral vascular injury and brain damage in most animals. At least part of the damage seemed to be the result of direct vascular injury, arterial and venous...
July 1976: Investigative Radiology
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